locus-tag	class	description
At12D1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
At12D1_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D1_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
At12D1_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
At12D1_RS00025	COG1420	regulation of RNA biosynthetic process
At12D1_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
At12D1_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D1_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
At12D1_RS00050	COG1137	ATPase activity
At12D1_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
At12D1_RS00065	COG0616	signal peptide processing
At12D1_RS00070	COG0776	regulation of translation
At12D1_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
At12D1_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D1_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
At12D1_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
At12D1_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
At12D1_RS00115	COG0728	peptidoglycan biosynthetic process
At12D1_RS00125	COG0180	Tryptophanyl-tRNA synthetase
At12D1_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
At12D1_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
At12D1_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D1_RS00165	COG1702	phosphate starvation-inducible protein PhoH
At12D1_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
At12D1_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
At12D1_RS00185	COG1396	sequence-specific DNA binding
At12D1_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
At12D1_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
At12D1_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS00210	COG0242	peptide deformylase activity
At12D1_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
At12D1_RS00220	COG0101	tRNA pseudouridine synthase activity
At12D1_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D1_RS00235	COG2171	N-acyltransferase activity
At12D1_RS00245	COG0840	transmembrane signaling receptor activity
At12D1_RS00250	COG1957	nucleoside hydrolase
At12D1_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D1_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
At12D1_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
At12D1_RS00295	COG0706	membrane insertase activity
At12D1_RS00300	COG0594	ribonuclease P activity
At12D1_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
At12D1_RS00310	COG0840	transmembrane signaling receptor activity
At12D1_RS00315	COG5002	protein histidine kinase activity
At12D1_RS00315	COG3850	Histidine kinase
At12D1_RS00335	COG3842	ATPase activity
At12D1_RS00340	COG1175	transmembrane transport
At12D1_RS00345	COG0395	ABC-type sugar transport system, permease component
At12D1_RS00360	COG0427	acetyl-CoA hydrolase
At12D1_RS00370	COG3938	Belongs to the proline racemase family
At12D1_RS00375	COG0418	dihydroorotase activity
At12D1_RS00380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
At12D1_RS00400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
At12D1_RS00405	COG0166	Belongs to the GPI family
At12D1_RS00410	COG0318	PFAM AMP-dependent synthetase and ligase
At12D1_RS00415	COG3842	ATPase activity
At12D1_RS00420	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D1_RS00425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D1_RS00430	COG4774	siderophore transport
At12D1_RS00475	COG2326	polyphosphate kinase activity
At12D1_RS00480	COG5002	protein histidine kinase activity
At12D1_RS00485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
At12D1_RS00490	COG0573	inorganic phosphate transmembrane transporter activity
At12D1_RS00500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
At12D1_RS00505	COG0704	Plays a role in the regulation of phosphate uptake
At12D1_RS00510	COG0745	RESPONSE REGULATOR receiver
At12D1_RS00525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
At12D1_RS00530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
At12D1_RS00540	COG2967	ApaG domain
At12D1_RS00550	COG0717	Belongs to the dCTP deaminase family
At12D1_RS00560	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
At12D1_RS00565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
At12D1_RS00615	COG0167	dihydroorotate dehydrogenase activity
At12D1_RS00630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D1_RS00650	COG1959	2 iron, 2 sulfur cluster binding
At12D1_RS00655	COG1201	RNA secondary structure unwinding
At12D1_RS00690	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS00700	COG0183	Belongs to the thiolase family
At12D1_RS00705	COG1024	Enoyl-CoA hydratase
At12D1_RS00705	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D1_RS00730	COG1320	monovalent cation:proton antiporter activity
At12D1_RS00735	COG2212	antiporter activity
At12D1_RS00740	COG1863	multisubunit Na H antiporter MnhE subunit
At12D1_RS00745	COG0651	ATP synthesis coupled electron transport
At12D1_RS00750	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D1_RS00755	COG2111	Na H antiporter
At12D1_RS00755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
At12D1_RS00765	COG0840	transmembrane signaling receptor activity
At12D1_RS00775	COG0745	RESPONSE REGULATOR receiver
At12D1_RS00780	COG0643	Histidine kinase
At12D1_RS00780	COG2198	Histidine kinase
At12D1_RS00785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
At12D1_RS00790	COG2201	protein-glutamate methylesterase activity
At12D1_RS00795	COG0745	RESPONSE REGULATOR receiver
At12D1_RS00800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
At12D1_RS00810	COG1766	The M ring may be actively involved in energy transduction
At12D1_RS00815	COG2771	luxR family
At12D1_RS00825	COG2972	Histidine kinase
At12D1_RS00825	COG0840	transmembrane signaling receptor activity
At12D1_RS00830	COG2198	Histidine kinase
At12D1_RS00830	COG0784	Response regulator, receiver
At12D1_RS00830	COG2205	protein histidine kinase activity
At12D1_RS00835	COG1970	mechanosensitive ion channel activity
At12D1_RS00840	COG0436	Aminotransferase
At12D1_RS00855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
At12D1_RS00860	COG0424	maF-like protein
At12D1_RS00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
At12D1_RS00875	COG5328	Belongs to the UPF0262 family
At12D1_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
At12D1_RS00890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
At12D1_RS00910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
At12D1_RS00925	COG1338	Plays a role in the flagellum-specific transport system
At12D1_RS00935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
At12D1_RS00945	COG1706	bacterial-type flagellum-dependent cell motility
At12D1_RS00950	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
At12D1_RS00955	COG4786	Flagellar basal body rod
At12D1_RS00960	COG1677	Flagellar hook-basal body complex protein FliE
At12D1_RS00965	COG1558	bacterial-type flagellum-dependent cell motility
At12D1_RS00970	COG1815	bacterial-type flagellum-dependent cell motility
At12D1_RS00980	COG1157	protein secretion by the type III secretion system
At12D1_RS00985	COG4786	Flagellar basal body rod
At12D1_RS00995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
At12D1_RS01000	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D1_RS01005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D1_RS01010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D1_RS01015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D1_RS01040	COG1360	Flagellar Motor Protein
At12D1_RS01065	COG1749	Flagellar hook protein flgE
At12D1_RS01085	COG5443	negative regulation of bacterial-type flagellum assembly
At12D1_RS01090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
At12D1_RS01100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D1_RS01140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
At12D1_RS01145	COG1609	Transcriptional regulator
At12D1_RS01150	COG1653	transport
At12D1_RS01155	COG1175	transmembrane transport
At12D1_RS01160	COG0395	ABC-type sugar transport system, permease component
At12D1_RS01165	COG0366	Alpha amylase catalytic
At12D1_RS01170	COG3842	ATPase activity
At12D1_RS01185	COG0129	dihydroxy-acid dehydratase activity
At12D1_RS01190	COG0363	glucosamine-6-phosphate deaminase activity
At12D1_RS01195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
At12D1_RS01205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS01215	COG2081	HI0933 family
At12D1_RS01235	COG2224	Isocitrate lyase
At12D1_RS01250	COG3842	ATPase activity
At12D1_RS01255	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D1_RS01260	COG1177	transmembrane transport
At12D1_RS01270	COG2205	protein histidine kinase activity
At12D1_RS01280	COG0248	Ppx GppA phosphatase
At12D1_RS01285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
At12D1_RS01290	COG0477	Major facilitator Superfamily
At12D1_RS01330	COG0521	Mo-molybdopterin cofactor biosynthetic process
At12D1_RS01335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
At12D1_RS01345	COG0142	geranyltranstransferase activity
At12D1_RS01370	COG0752	glycyl-tRNA synthetase alpha subunit
At12D1_RS01380	COG1704	LemA family
At12D1_RS01385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
At12D1_RS01395	COG0751	glycine-tRNA ligase activity
At12D1_RS01405	COG1683	Conserved Protein
At12D1_RS01410	COG0840	transmembrane signaling receptor activity
At12D1_RS01420	COG0151	Belongs to the GarS family
At12D1_RS01425	COG2183	response to ionizing radiation
At12D1_RS01430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D1_RS01455	COG0583	DNA-binding transcription factor activity
At12D1_RS01475	COG0306	phosphate transporter
At12D1_RS01485	COG0561	phosphatase activity
At12D1_RS01490	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS01495	COG2186	Transcriptional regulator
At12D1_RS01510	COG0583	DNA-binding transcription factor activity
At12D1_RS01515	COG0277	FAD linked oxidase domain protein
At12D1_RS01525	COG0277	FAD linked oxidase domain protein
At12D1_RS01530	COG0247	lactate metabolic process
At12D1_RS01545	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS01550	COG2818	Glycosylase
At12D1_RS01560	COG2855	membrane
At12D1_RS01565	COG0583	DNA-binding transcription factor activity
At12D1_RS01595	COG0124	histidyl-tRNA synthetase
At12D1_RS01605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
At12D1_RS01610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
At12D1_RS01615	COG2259	Doxx family
At12D1_RS01625	COG0459	protein refolding
At12D1_RS01630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
At12D1_RS01640	COG0196	riboflavin kinase activity
At12D1_RS01645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
At12D1_RS01655	COG0590	tRNA wobble adenosine to inosine editing
At12D1_RS01660	COG1187	pseudouridine synthase activity
At12D1_RS01665	COG0742	ribosomal rna small subunit methyltransferase
At12D1_RS01675	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D1_RS01690	COG0312	modulator of DNA gyrase
At12D1_RS01695	COG0483	inositol monophosphate 1-phosphatase activity
At12D1_RS01705	COG1519	Transferase
At12D1_RS01715	COG1663	tetraacyldisaccharide 4'-kinase activity
At12D1_RS01725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
At12D1_RS01730	COG0745	RESPONSE REGULATOR receiver
At12D1_RS01735	COG5001	Diguanylate cyclase
At12D1_RS01735	COG3300	MHYT domain
At12D1_RS01745	COG3386	PFAM SMP-30 Gluconolaconase
At12D1_RS01750	COG0800	Aldolase
At12D1_RS01755	COG3734	2-keto-3-deoxy-galactonokinase
At12D1_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS01765	COG1414	Transcriptional regulator
At12D1_RS01770	COG2197	response regulator
At12D1_RS01785	COG0598	Magnesium transport protein CorA
At12D1_RS01790	COG3158	transport of potassium into the cell
At12D1_RS01805	COG0356	it plays a direct role in the translocation of protons across the membrane
At12D1_RS01815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D1_RS01820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D1_RS01835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
At12D1_RS01855	COG0009	L-threonylcarbamoyladenylate synthase
At12D1_RS01865	COG4638	Rieske (2fe-2S)
At12D1_RS01890	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS01905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
At12D1_RS01910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
At12D1_RS01915	COG0840	transmembrane signaling receptor activity
At12D1_RS01925	COG1522	sequence-specific DNA binding
At12D1_RS01945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
At12D1_RS01950	COG1741	Belongs to the pirin family
At12D1_RS01955	COG1722	exodeoxyribonuclease VII activity
At12D1_RS01960	COG0123	including yeast histone deacetylase and acetoin utilization protein
At12D1_RS01965	COG1268	BioY protein
At12D1_RS01970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
At12D1_RS01975	COG1122	ATPase activity
At12D1_RS01980	COG3214	Protein conserved in bacteria
At12D1_RS01985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D1_RS01985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D1_RS01990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
At12D1_RS02005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D1_RS02020	COG0259	pyridoxamine-phosphate oxidase activity
At12D1_RS02040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D1_RS02050	COG0312	modulator of DNA gyrase
At12D1_RS02065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D1_RS02070	COG0109	protoheme IX farnesyltransferase activity
At12D1_RS02080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
At12D1_RS02095	COG3346	SURF1 family
At12D1_RS02100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
At12D1_RS02105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
At12D1_RS02110	COG0328	RNA-DNA hybrid ribonuclease activity
At12D1_RS02120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
At12D1_RS02120	COG0678	peroxiredoxin activity
At12D1_RS02130	COG1678	Uncharacterized ACR, COG1678
At12D1_RS02135	COG3237	CsbD-like
At12D1_RS02145	COG3300	MHYT domain
At12D1_RS02145	COG5001	Diguanylate cyclase
At12D1_RS02150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
At12D1_RS02155	COG0612	Peptidase, M16
At12D1_RS02180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D1_RS02185	COG1802	Transcriptional regulator
At12D1_RS02210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
At12D1_RS02220	COG3609	addiction module antidote protein, CC2985 family
At12D1_RS02225	COG3668	Plasmid stabilization system
At12D1_RS02235	COG1194	a g-specific adenine glycosylase
At12D1_RS02250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
At12D1_RS02255	COG1196	nuclear chromosome segregation
At12D1_RS02260	COG2514	catechol 2,3-dioxygenase activity
At12D1_RS02265	COG0574	Belongs to the PEP-utilizing enzyme family
At12D1_RS02265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
At12D1_RS02280	COG1823	symporter activity
At12D1_RS02315	COG1846	Transcriptional regulator
At12D1_RS02320	COG2807	transmembrane transport
At12D1_RS02325	COG2211	Major facilitator Superfamily
At12D1_RS02340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
At12D1_RS02355	COG0583	DNA-binding transcription factor activity
At12D1_RS02415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS02430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
At12D1_RS02435	COG5290	Psort location Cytoplasmic, score
At12D1_RS02490	COG0579	oxidoreductase
At12D1_RS02510	COG2895	sulfate adenylyltransferase (ATP) activity
At12D1_RS02515	COG0175	sulfate reduction
At12D1_RS02520	COG0175	sulfate reduction
At12D1_RS02525	COG1959	2 iron, 2 sulfur cluster binding
At12D1_RS02530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
At12D1_RS02535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D1_RS02540	COG4208	sulfate ABC transporter
At12D1_RS02545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D1_RS02560	COG2203	Gaf domain
At12D1_RS02560	COG2200	EAL domain
At12D1_RS02560	COG2199	diguanylate cyclase activity
At12D1_RS02570	COG1309	transcriptional regulator
At12D1_RS02575	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS02585	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
At12D1_RS02615	COG0625	glutathione transferase activity
At12D1_RS02625	COG0477	Major facilitator Superfamily
At12D1_RS02635	COG3657	addiction module killer protein
At12D1_RS02645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
At12D1_RS02645	COG1793	dna ligase
At12D1_RS02665	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS02670	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS02675	COG1846	Transcriptional regulator
At12D1_RS02680	COG1764	response to oxidative stress
At12D1_RS02695	COG0488	(ABC) transporter
At12D1_RS02730	COG4221	oxidoreductase activity
At12D1_RS02745	COG0433	COG0433 Predicted ATPase
At12D1_RS02760	COG1733	regulation of RNA biosynthetic process
At12D1_RS02765	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
At12D1_RS02780	COG0656	L-ascorbic acid biosynthetic process
At12D1_RS02785	COG3781	membrane
At12D1_RS02790	COG2378	regulation of single-species biofilm formation
At12D1_RS02805	COG4106	trans-aconitate 2-methyltransferase activity
At12D1_RS02810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D1_RS02815	COG0840	transmembrane signaling receptor activity
At12D1_RS02820	COG0583	DNA-binding transcription factor activity
At12D1_RS02835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D1_RS02855	COG3909	cytochrome
At12D1_RS02860	COG2010	Cytochrome c
At12D1_RS02890	COG0789	Transcriptional regulator
At12D1_RS02915	COG0517	IMP dehydrogenase activity
At12D1_RS02915	COG4175	Glycine betaine
At12D1_RS02920	COG4176	ABC-type proline glycine betaine transport system permease component
At12D1_RS02945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS02955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D1_RS02955	COG2169	Transcriptional regulator
At12D1_RS02965	COG2514	catechol 2,3-dioxygenase activity
At12D1_RS02990	COG1272	protein, Hemolysin III
At12D1_RS03000	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS03005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D1_RS03010	COG2111	Na H antiporter
At12D1_RS03010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
At12D1_RS03015	COG2111	Na H antiporter
At12D1_RS03020	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D1_RS03025	COG0651	ATP synthesis coupled electron transport
At12D1_RS03030	COG1863	multisubunit Na H antiporter MnhE subunit
At12D1_RS03035	COG2212	antiporter activity
At12D1_RS03040	COG1320	monovalent cation:proton antiporter activity
At12D1_RS03045	COG4957	zinc ion binding
At12D1_RS03060	COG2166	iron-sulfur cluster assembly
At12D1_RS03070	COG2205	protein histidine kinase activity
At12D1_RS03120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D1_RS03125	COG2983	Belongs to the UPF0260 family
At12D1_RS03135	COG3041	Addiction module toxin RelE StbE family
At12D1_RS03140	COG3077	Addiction module antitoxin, RelB DinJ family
At12D1_RS03145	COG2217	Heavy metal translocating P-type atpase
At12D1_RS03175	COG2814	Major facilitator Superfamily
At12D1_RS03185	COG1621	beta-fructofuranosidase activity
At12D1_RS03190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
At12D1_RS03240	COG4695	Portal protein
At12D1_RS03345	COG4235	cytochrome complex assembly
At12D1_RS03350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
At12D1_RS03355	COG1138	Cytochrome C-type biogenesis protein
At12D1_RS03360	COG3088	subunit of a heme lyase
At12D1_RS03365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D1_RS03370	COG0745	RESPONSE REGULATOR receiver
At12D1_RS03380	COG3011	Protein conserved in bacteria
At12D1_RS03385	COG3713	MltA-interacting MipA family protein
At12D1_RS03390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
At12D1_RS03400	COG2202	Pas domain
At12D1_RS03400	COG2205	protein histidine kinase activity
At12D1_RS03410	COG0308	aminopeptidase N
At12D1_RS03420	COG2433	Pfam Transposase IS66
At12D1_RS03425	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS03430	COG2963	transposase activity
At12D1_RS03440	COG0697	spore germination
At12D1_RS03460	COG0443	Heat shock 70 kDa protein
At12D1_RS03495	COG0604	alcohol dehydrogenase
At12D1_RS03500	COG1733	regulation of RNA biosynthetic process
At12D1_RS03505	COG1968	undecaprenyl-diphosphatase activity
At12D1_RS03510	COG2239	Acts as a magnesium transporter
At12D1_RS03515	COG2814	Major facilitator Superfamily
At12D1_RS03540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
At12D1_RS03565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D1_RS03610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
At12D1_RS03615	COG0741	lytic transglycosylase activity
At12D1_RS03625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS03630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
At12D1_RS03635	COG0840	transmembrane signaling receptor activity
At12D1_RS03645	COG1758	RNA polymerase activity
At12D1_RS03670	COG0736	holo-[acyl-carrier-protein] synthase activity
At12D1_RS03675	COG0681	Belongs to the peptidase S26 family
At12D1_RS03680	COG0571	ribonuclease III activity
At12D1_RS03685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
At12D1_RS03695	COG0784	Response regulator, receiver
At12D1_RS03700	COG1381	Involved in DNA repair and RecF pathway recombination
At12D1_RS03710	COG2226	methyltransferase
At12D1_RS03725	COG1418	mRNA catabolic process
At12D1_RS03735	COG0346	lactoylglutathione lyase activity
At12D1_RS03745	COG1116	anion transmembrane transporter activity
At12D1_RS03750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS03755	COG3443	Belongs to the bacterial solute-binding protein 9 family
At12D1_RS03760	COG0668	transmembrane transport
At12D1_RS03770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
At12D1_RS03800	COG1742	UPF0060 membrane protein
At12D1_RS03815	COG1183	phosphatidylcholine synthase activity
At12D1_RS03820	COG0688	phosphatidylethanolamine metabolic process
At12D1_RS03825	COG5265	(ABC) transporter
At12D1_RS03865	COG2852	Protein conserved in bacteria
At12D1_RS03870	COG0215	cysteine-tRNA ligase activity
At12D1_RS03875	COG4221	oxidoreductase activity
At12D1_RS03880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
At12D1_RS03885	COG1286	toxin biosynthetic process
At12D1_RS03905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D1_RS03915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
At12D1_RS03925	COG0305	Participates in initiation and elongation during chromosome replication
At12D1_RS03950	COG0359	binds to the 23S rRNA
At12D1_RS03960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
At12D1_RS03965	COG0360	Binds together with S18 to 16S ribosomal RNA
At12D1_RS03980	COG0667	Aldo Keto reductase
At12D1_RS03985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
At12D1_RS03995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D1_RS04000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D1_RS04010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
At12D1_RS04015	COG1561	YicC-like family, N-terminal region
At12D1_RS04020	COG0194	GDP metabolic process
At12D1_RS04035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D1_RS04040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D1_RS04050	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
At12D1_RS04065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D1_RS04085	COG2203	Gaf domain
At12D1_RS04085	COG4251	negative regulation of phosphorylation
At12D1_RS04085	COG5001	Diguanylate cyclase
At12D1_RS04085	COG3706	GGDEF domain
At12D1_RS04090	COG5001	Diguanylate cyclase
At12D1_RS04090	COG3300	MHYT domain
At12D1_RS04095	COG4191	Histidine kinase
At12D1_RS04100	COG4566	intracellular signal transduction
At12D1_RS04110	COG0488	(ABC) transporter
At12D1_RS04115	COG3706	GGDEF domain
At12D1_RS04125	COG0105	UTP biosynthetic process
At12D1_RS04145	COG0314	molybdopterin synthase activity
At12D1_RS04155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
At12D1_RS04160	COG0322	excinuclease ABC activity
At12D1_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS04190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
At12D1_RS04195	COG0243	molybdopterin cofactor binding
At12D1_RS04220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
At12D1_RS04225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
At12D1_RS04230	COG2226	methyltransferase
At12D1_RS04235	COG0628	permease
At12D1_RS04245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
At12D1_RS04250	COG0248	Ppx GppA phosphatase
At12D1_RS04275	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
At12D1_RS04285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
At12D1_RS04290	COG0477	Major facilitator Superfamily
At12D1_RS04295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
At12D1_RS04305	COG0840	transmembrane signaling receptor activity
At12D1_RS04310	COG0659	secondary active sulfate transmembrane transporter activity
At12D1_RS04320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D1_RS04325	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
At12D1_RS04335	COG0113	porphobilinogen synthase activity
At12D1_RS04355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D1_RS04360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
At12D1_RS04365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D1_RS04365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D1_RS04375	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS04380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
At12D1_RS04385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D1_RS04390	COG2814	Major facilitator Superfamily
At12D1_RS04395	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
At12D1_RS04415	COG0416	fatty acid biosynthetic process
At12D1_RS04420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D1_RS04425	COG0776	regulation of translation
At12D1_RS04460	COG0601	transmembrane transport
At12D1_RS04465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS04470	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS04480	COG0747	negative chemotaxis
At12D1_RS04490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
At12D1_RS04495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
At12D1_RS04510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D1_RS04515	COG0583	DNA-binding transcription factor activity
At12D1_RS04520	COG0737	Belongs to the 5'-nucleotidase family
At12D1_RS04540	COG2897	thiosulfate sulfurtransferase activity
At12D1_RS04555	COG0415	Belongs to the DNA photolyase family
At12D1_RS04565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D1_RS04595	COG3932	Exopolysaccharide synthesis, ExoD
At12D1_RS04600	COG1238	metal cluster binding
At12D1_RS04675	COG1612	heme a metabolic process
At12D1_RS04685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
At12D1_RS04690	COG0010	Belongs to the arginase family
At12D1_RS04695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
At12D1_RS04700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
At12D1_RS04715	COG1832	CoA-binding protein
At12D1_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS04745	COG2124	cytochrome p450
At12D1_RS04750	COG2199	diguanylate cyclase activity
At12D1_RS04755	COG0740	serine-type endopeptidase activity
At12D1_RS04760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
At12D1_RS04770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
At12D1_RS04780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D1_RS04800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D1_RS04805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D1_RS04810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D1_RS04820	COG0649	NAD binding
At12D1_RS04830	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
At12D1_RS04835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
At12D1_RS04845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
At12D1_RS04850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D1_RS04860	COG0713	ATP synthesis coupled electron transport
At12D1_RS04875	COG1007	ATP synthesis coupled electron transport
At12D1_RS04880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
At12D1_RS04880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
At12D1_RS04900	COG0442	prolyl-tRNA aminoacylation
At12D1_RS04910	COG1136	(ABC) transporter
At12D1_RS04930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D1_RS04950	COG0784	Response regulator, receiver
At12D1_RS04965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
At12D1_RS04970	COG0477	Major facilitator Superfamily
At12D1_RS04985	COG0557	exoribonuclease II activity
At12D1_RS04990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
At12D1_RS05000	COG0758	DNA mediated transformation
At12D1_RS05005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
At12D1_RS05015	COG0540	Belongs to the ATCase OTCase family
At12D1_RS05030	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS05035	COG0456	acetyltransferase
At12D1_RS05050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
At12D1_RS05055	COG2824	Alkylphosphonate utilization operon protein PhnA
At12D1_RS05060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
At12D1_RS05065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D1_RS05070	COG0154	amidase activity
At12D1_RS05075	COG0456	acetyltransferase
At12D1_RS05080	COG3811	Belongs to the UPF0386 family
At12D1_RS05095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D1_RS05105	COG0456	acetyltransferase
At12D1_RS05125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
At12D1_RS05130	COG0439	Biotin carboxylase
At12D1_RS05135	COG0511	ligase activity, forming carbon-carbon bonds
At12D1_RS05140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D1_RS05150	COG0436	Aminotransferase
At12D1_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS05180	COG1530	ribonuclease E activity
At12D1_RS05195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D1_RS05215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
At12D1_RS05220	COG0384	phenazine biosynthesis protein PhzF
At12D1_RS05240	COG0633	Ferredoxin
At12D1_RS05250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
At12D1_RS05255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
At12D1_RS05260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
At12D1_RS05270	COG3768	UPF0283 membrane protein
At12D1_RS05275	COG3106	COG3106 Predicted ATPase
At12D1_RS05305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D1_RS05340	COG0537	adenosine 5'-monophosphoramidase activity
At12D1_RS05365	COG0052	Belongs to the universal ribosomal protein uS2 family
At12D1_RS05370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
At12D1_RS05375	COG0528	UMP kinase activity
At12D1_RS05380	COG0233	cytoplasmic translational termination
At12D1_RS05385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
At12D1_RS05395	COG0750	zinc metalloprotease
At12D1_RS05400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D1_RS05405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D1_RS05410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D1_RS05415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D1_RS05420	COG3494	Protein of unknown function (DUF1009)
At12D1_RS05425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D1_RS05430	COG2186	Transcriptional regulator
At12D1_RS05440	COG0765	amino acid transport
At12D1_RS05445	COG0765	amino acid transport
At12D1_RS05455	COG0372	Belongs to the citrate synthase family
At12D1_RS05470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
At12D1_RS05480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
At12D1_RS05485	COG0148	phosphopyruvate hydratase activity
At12D1_RS05495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
At12D1_RS05500	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D1_RS05500	COG0022	dehydrogenase e1 component
At12D1_RS05505	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D1_RS05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
At12D1_RS05525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
At12D1_RS05530	COG0697	spore germination
At12D1_RS05550	COG2867	negative regulation of translational initiation
At12D1_RS05555	COG1058	Belongs to the CinA family
At12D1_RS05555	COG1546	Belongs to the CinA family
At12D1_RS05560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
At12D1_RS05560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
At12D1_RS05570	COG3852	Histidine kinase
At12D1_RS05575	COG2204	response regulator
At12D1_RS05580	COG5000	phosphorelay sensor kinase activity
At12D1_RS05585	COG2204	response regulator
At12D1_RS05590	COG0569	domain protein
At12D1_RS05595	COG1923	regulation of RNA biosynthetic process
At12D1_RS05600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
At12D1_RS05605	COG3956	TIGRFAM MazG family protein
At12D1_RS05620	COG1648	precorrin-2 dehydrogenase activity
At12D1_RS05620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D1_RS05660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D1_RS05660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D1_RS05665	COG0509	glycine decarboxylation via glycine cleavage system
At12D1_RS05670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D1_RS05695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
At12D1_RS05700	COG0564	pseudouridine synthase activity
At12D1_RS05720	COG0251	oxidation-reduction process
At12D1_RS05725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
At12D1_RS05735	COG1671	Belongs to the UPF0178 family
At12D1_RS05750	COG0450	alkyl hydroperoxide reductase
At12D1_RS05755	COG0625	glutathione transferase activity
At12D1_RS05770	COG0431	NADPH-dependent FMN reductase
At12D1_RS05780	COG0798	PFAM Bile acid sodium symporter
At12D1_RS05800	COG0321	lipoyl(octanoyl) transferase activity
At12D1_RS05800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
At12D1_RS05805	COG0084	hydrolase, TatD family'
At12D1_RS05810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D1_RS05820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
At12D1_RS05875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D1_RS05880	COG2095	MarC family integral membrane protein
At12D1_RS05885	COG0617	tRNA 3'-terminal CCA addition
At12D1_RS05885	COG0517	IMP dehydrogenase activity
At12D1_RS05885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
At12D1_RS05895	COG0629	single-stranded DNA binding
At12D1_RS05900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
At12D1_RS05910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
At12D1_RS05930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D1_RS05935	COG1121	(ABC) transporter
At12D1_RS05955	COG0667	Aldo Keto reductase
At12D1_RS06035	COG1396	sequence-specific DNA binding
At12D1_RS06085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D1_RS06115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
At12D1_RS06200	COG2239	Acts as a magnesium transporter
At12D1_RS06205	COG0243	molybdopterin cofactor binding
At12D1_RS06215	COG0242	peptide deformylase activity
At12D1_RS06230	COG2205	protein histidine kinase activity
At12D1_RS06230	COG2202	Pas domain
At12D1_RS06245	COG0321	lipoyl(octanoyl) transferase activity
At12D1_RS06250	COG1064	alcohol dehydrogenase
At12D1_RS06280	COG1862	Preprotein translocase
At12D1_RS06300	COG2124	cytochrome p450
At12D1_RS06315	COG0596	Alpha beta hydrolase
At12D1_RS06325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D1_RS06330	COG0626	cystathionine gamma-synthase activity
At12D1_RS06335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS06340	COG4597	amino acid ABC transporter
At12D1_RS06345	COG0765	amino acid transport
At12D1_RS06350	COG1126	abc transporter atp-binding protein
At12D1_RS06370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
At12D1_RS06385	COG0436	Aminotransferase
At12D1_RS06415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D1_RS06425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D1_RS06430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D1_RS06435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D1_RS06450	COG3243	poly(R)-hydroxyalkanoic acid synthase
At12D1_RS06455	COG1489	DNA binding
At12D1_RS06460	COG0024	Methionine aminopeptidase
At12D1_RS06465	COG2003	Belongs to the UPF0758 family
At12D1_RS06480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
At12D1_RS06505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
At12D1_RS06510	COG0546	phosphoglycolate phosphatase activity
At12D1_RS06520	COG0114	fumarate hydratase activity
At12D1_RS06530	COG0504	CTP synthase activity
At12D1_RS06540	COG0149	triose-phosphate isomerase activity
At12D1_RS06550	COG0187	DNA topoisomerase II activity
At12D1_RS06560	COG0740	serine-type endopeptidase activity
At12D1_RS06570	COG0640	Transcriptional regulator
At12D1_RS06575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D1_RS06580	COG0745	RESPONSE REGULATOR receiver
At12D1_RS06605	COG3264	Mechanosensitive ion channel
At12D1_RS06605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
At12D1_RS06680	COG1127	ABC transporter
At12D1_RS06685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
At12D1_RS06690	COG4948	Mandelate Racemase Muconate Lactonizing
At12D1_RS06700	COG0280	phosphate acetyltransferase
At12D1_RS06700	COG0281	malic enzyme
At12D1_RS06710	COG0778	Nitroreductase
At12D1_RS06715	COG0823	Involved in the tonB-independent uptake of proteins
At12D1_RS06730	COG1368	sulfuric ester hydrolase activity
At12D1_RS06750	COG3265	gluconokinase activity
At12D1_RS06755	COG0544	peptidyl-prolyl cis-trans isomerase activity
At12D1_RS06780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
At12D1_RS06800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
At12D1_RS06815	COG0318	PFAM AMP-dependent synthetase and ligase
At12D1_RS06825	COG0512	Glutamine amidotransferase of anthranilate synthase
At12D1_RS06825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
At12D1_RS06830	COG0343	queuine tRNA-ribosyltransferase activity
At12D1_RS06835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
At12D1_RS06855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
At12D1_RS06880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D1_RS06885	COG0134	indole-3-glycerol-phosphate synthase activity
At12D1_RS06890	COG0315	cyclic pyranopterin monophosphate synthase activity
At12D1_RS06895	COG0303	'Molybdopterin
At12D1_RS06900	COG3706	GGDEF domain
At12D1_RS06910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
At12D1_RS06910	COG0475	glutathione-regulated potassium exporter activity
At12D1_RS06920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
At12D1_RS06930	COG2814	Major facilitator Superfamily
At12D1_RS06935	COG0746	molybdenum cofactor guanylyltransferase activity
At12D1_RS06940	COG1763	Mo-molybdopterin cofactor biosynthetic process
At12D1_RS06945	COG0739	heme binding
At12D1_RS06950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D1_RS06955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
At12D1_RS06960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D1_RS06965	COG0805	protein transport
At12D1_RS06970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D1_RS06975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D1_RS06980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
At12D1_RS06985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
At12D1_RS06990	COG1472	Belongs to the glycosyl hydrolase 3 family
At12D1_RS07000	COG0018	arginyl-trna synthetase
At12D1_RS07005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
At12D1_RS07040	COG0525	valine-tRNA ligase activity
At12D1_RS07050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D1_RS07085	COG0655	NAD(P)H dehydrogenase (quinone) activity
At12D1_RS07090	COG1546	Belongs to the CinA family
At12D1_RS07090	COG1058	Belongs to the CinA family
At12D1_RS07095	COG0589	response to stress
At12D1_RS07100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
At12D1_RS07105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
At12D1_RS07150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
At12D1_RS07165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
At12D1_RS07205	COG0640	Transcriptional regulator
At12D1_RS07210	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D1_RS07220	COG1132	(ABC) transporter
At12D1_RS07225	COG0628	permease
At12D1_RS07260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
At12D1_RS07270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
At12D1_RS07280	COG0302	gtp cyclohydrolase
At12D1_RS07285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
At12D1_RS07290	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D1_RS07300	COG0516	GMP reductase activity
At12D1_RS07300	COG0517	IMP dehydrogenase activity
At12D1_RS07340	COG1760	l-serine dehydratase
At12D1_RS07375	COG0583	DNA-binding transcription factor activity
At12D1_RS07390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
At12D1_RS07390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
At12D1_RS07400	COG0347	Belongs to the P(II) protein family
At12D1_RS07405	COG0174	glutamine synthetase
At12D1_RS07440	COG0697	spore germination
At12D1_RS07450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
At12D1_RS07460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
At12D1_RS07490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
At12D1_RS07495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D1_RS07500	COG2186	Transcriptional regulator
At12D1_RS07510	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS07515	COG4603	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS07520	COG3845	ABC transporter
At12D1_RS07525	COG1183	phosphatidylcholine synthase activity
At12D1_RS07530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D1_RS07535	COG0679	Auxin Efflux Carrier
At12D1_RS07540	COG0785	Cytochrome C biogenesis protein
At12D1_RS07565	COG1278	Cold shock
At12D1_RS07625	COG0577	efflux transmembrane transporter activity
At12D1_RS07625	COG1136	(ABC) transporter
At12D1_RS07630	COG1136	(ABC) transporter
At12D1_RS07630	COG0577	efflux transmembrane transporter activity
At12D1_RS07655	COG2151	metal-sulfur cluster biosynthetic enzyme
At12D1_RS07660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
At12D1_RS07665	COG0719	Fe-S assembly protein
At12D1_RS07670	COG0396	ATPase activity
At12D1_RS07675	COG0719	Fe-S assembly protein
At12D1_RS07680	COG1104	cysteine desulfurase activity
At12D1_RS07685	COG2945	thiolester hydrolase activity
At12D1_RS07690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
At12D1_RS07695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
At12D1_RS07705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
At12D1_RS07710	COG2833	Protein of unknown function (DUF455)
At12D1_RS07715	COG0739	heme binding
At12D1_RS07720	COG0513	Belongs to the DEAD box helicase family
At12D1_RS07745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
At12D1_RS07755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D1_RS07760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D1_RS07765	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D1_RS07785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D1_RS07790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D1_RS07815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
At12D1_RS07820	COG2814	Major facilitator Superfamily
At12D1_RS07825	COG0483	inositol monophosphate 1-phosphatase activity
At12D1_RS07830	COG0483	inositol monophosphate 1-phosphatase activity
At12D1_RS07835	COG0037	tRNA processing
At12D1_RS07840	COG2066	Belongs to the glutaminase family
At12D1_RS07845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
At12D1_RS07850	COG0861	Integral membrane protein TerC family
At12D1_RS07865	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS07880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
At12D1_RS07885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
At12D1_RS07895	COG0538	isocitrate dehydrogenase activity
At12D1_RS07905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
At12D1_RS07910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
At12D1_RS07915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS07920	COG2313	pseudouridylate synthase activity
At12D1_RS07935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS07940	COG4215	(ABC) transporter
At12D1_RS07950	COG5425	PFAM Usg family protein
At12D1_RS07960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS07965	COG1522	sequence-specific DNA binding
At12D1_RS07970	COG1573	uracil-dna glycosylase
At12D1_RS07980	COG2202	Pas domain
At12D1_RS07980	COG2205	protein histidine kinase activity
At12D1_RS07985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
At12D1_RS07990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
At12D1_RS07995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
At12D1_RS08010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D1_RS08015	COG0842	Transport permease protein
At12D1_RS08020	COG1131	(ABC) transporter
At12D1_RS08025	COG0730	response to heat
At12D1_RS08025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D1_RS08050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
At12D1_RS08055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D1_RS08075	COG0129	dihydroxy-acid dehydratase activity
At12D1_RS08080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
At12D1_RS08085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
At12D1_RS08095	COG3739	integral membrane protein
At12D1_RS08100	COG0203	ribosomal protein L17
At12D1_RS08105	COG0202	RNA polymerase activity
At12D1_RS08110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
At12D1_RS08115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
At12D1_RS08120	COG0563	adenylate kinase activity
At12D1_RS08125	COG0201	protein transport
At12D1_RS08130	COG0200	Binds to the 23S rRNA
At12D1_RS08135	COG1841	ribosomal large subunit assembly
At12D1_RS08140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
At12D1_RS08145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
At12D1_RS08150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
At12D1_RS08155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
At12D1_RS08160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
At12D1_RS08165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
At12D1_RS08170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
At12D1_RS08175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
At12D1_RS08180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
At12D1_RS08185	COG0255	Belongs to the universal ribosomal protein uL29 family
At12D1_RS08190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
At12D1_RS08195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
At12D1_RS08200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
At12D1_RS08205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
At12D1_RS08210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
At12D1_RS08215	COG0089	rRNA binding
At12D1_RS08220	COG0088	Forms part of the polypeptide exit tunnel
At12D1_RS08225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
At12D1_RS08230	COG0051	transcription antitermination factor activity, RNA binding
At12D1_RS08235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D1_RS08240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
At12D1_RS08245	COG0049	tRNA binding
At12D1_RS08250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
At12D1_RS08270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
At12D1_RS08275	COG0085	RNA polymerase activity
At12D1_RS08280	COG0222	ribosome binding
At12D1_RS08285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
At12D1_RS08290	COG0081	regulation of translation
At12D1_RS08295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
At12D1_RS08305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
At12D1_RS08315	COG1086	Polysaccharide biosynthesis protein
At12D1_RS08320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D1_RS08325	COG0861	Integral membrane protein TerC family
At12D1_RS08360	COG1132	(ABC) transporter
At12D1_RS08365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D1_RS08385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D1_RS08420	COG2205	protein histidine kinase activity
At12D1_RS08420	COG2198	Histidine kinase
At12D1_RS08420	COG0784	Response regulator, receiver
At12D1_RS08420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS08425	COG0784	Response regulator, receiver
At12D1_RS08430	COG2202	Pas domain
At12D1_RS08430	COG3920	Histidine kinase
At12D1_RS08435	COG0784	Response regulator, receiver
At12D1_RS08440	COG4251	negative regulation of phosphorylation
At12D1_RS08455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D1_RS08460	COG1607	acyl-coa hydrolase
At12D1_RS08480	COG2910	NAD(P)H-binding
At12D1_RS08485	COG1733	regulation of RNA biosynthetic process
At12D1_RS08500	COG0556	nucleotide-excision repair
At12D1_RS08510	COG2382	esterase
At12D1_RS08530	COG0484	heat shock protein binding
At12D1_RS08555	COG3706	GGDEF domain
At12D1_RS08575	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D1_RS08585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D1_RS08600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
At12D1_RS08610	COG2207	Transcriptional regulator
At12D1_RS08615	COG1064	alcohol dehydrogenase
At12D1_RS08620	COG1252	NADH dehydrogenase
At12D1_RS08625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
At12D1_RS08630	COG2197	response regulator
At12D1_RS08635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
At12D1_RS08670	COG0656	L-ascorbic acid biosynthetic process
At12D1_RS08685	COG0440	acetolactate synthase activity
At12D1_RS08690	COG0028	Belongs to the TPP enzyme family
At12D1_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
At12D1_RS08705	COG3830	Belongs to the UPF0237 family
At12D1_RS08705	COG0560	Phosphoserine phosphatase
At12D1_RS08725	COG0330	HflC and HflK could
At12D1_RS08730	COG0330	HflC and HflK could
At12D1_RS08740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
At12D1_RS08775	COG0277	FAD linked oxidase domain protein
At12D1_RS08780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D1_RS08820	COG1335	isochorismatase
At12D1_RS08855	COG2264	protein methyltransferase activity
At12D1_RS08860	COG1999	signal sequence binding
At12D1_RS08870	COG0835	chemotaxis
At12D1_RS08880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
At12D1_RS08885	COG0583	DNA-binding transcription factor activity
At12D1_RS08895	COG1247	-acetyltransferase
At12D1_RS08905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
At12D1_RS08910	COG0497	DNA recombination
At12D1_RS08915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D1_RS08925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D1_RS08930	COG0849	cell division
At12D1_RS08935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
At12D1_RS08940	COG1181	Belongs to the D-alanine--D-alanine ligase family
At12D1_RS08945	COG0477	Major facilitator Superfamily
At12D1_RS08950	COG5001	Diguanylate cyclase
At12D1_RS08955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
At12D1_RS08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
At12D1_RS08965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D1_RS08975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
At12D1_RS08980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
At12D1_RS08990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
At12D1_RS09005	COG0275	rRNA processing
At12D1_RS09010	COG2001	Belongs to the MraZ family
At12D1_RS09020	COG3766	membrane
At12D1_RS09030	COG0754	glutathionylspermidine amidase activity
At12D1_RS09055	COG3023	N-Acetylmuramoyl-L-alanine amidase
At12D1_RS09085	COG4106	trans-aconitate 2-methyltransferase activity
At12D1_RS09105	COG2226	methyltransferase
At12D1_RS09115	COG2267	carboxylic ester hydrolase activity
At12D1_RS09120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
At12D1_RS09135	COG0251	oxidation-reduction process
At12D1_RS09150	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS09155	COG2814	Major facilitator Superfamily
At12D1_RS09190	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS09195	COG0174	glutamine synthetase
At12D1_RS09200	COG0531	amino acid
At12D1_RS09210	COG1737	Transcriptional regulator
At12D1_RS09220	COG2182	Extracellular solute-binding protein
At12D1_RS09235	COG3842	ATPase activity
At12D1_RS09295	COG2968	Membrane
At12D1_RS09305	COG0432	Pfam Uncharacterised protein family UPF0047
At12D1_RS09320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D1_RS09325	COG0358	DNA primase activity
At12D1_RS09350	COG0505	Belongs to the CarA family
At12D1_RS09355	COG0534	Mate efflux family protein
At12D1_RS09370	COG2321	neutral zinc metallopeptidase
At12D1_RS09385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
At12D1_RS09395	COG3706	GGDEF domain
At12D1_RS09410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D1_RS09420	COG1522	sequence-specific DNA binding
At12D1_RS09425	COG0492	ferredoxin-NADP+ reductase activity
At12D1_RS09430	COG0583	DNA-binding transcription factor activity
At12D1_RS09440	COG1902	pentaerythritol trinitrate reductase activity
At12D1_RS09470	COG0387	Pfam Sodium calcium exchanger
At12D1_RS09475	COG0436	Aminotransferase
At12D1_RS09480	COG2199	diguanylate cyclase activity
At12D1_RS09480	COG2200	EAL domain
At12D1_RS09495	COG1278	Cold shock
At12D1_RS09500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D1_RS09515	COG1846	Transcriptional regulator
At12D1_RS09520	COG0745	RESPONSE REGULATOR receiver
At12D1_RS09530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D1_RS09555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
At12D1_RS09565	COG1496	oxidoreductase activity
At12D1_RS09580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
At12D1_RS09590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
At12D1_RS09605	COG0840	transmembrane signaling receptor activity
At12D1_RS09610	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS09615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
At12D1_RS09620	COG5001	Diguanylate cyclase
At12D1_RS09620	COG3300	MHYT domain
At12D1_RS09625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
At12D1_RS09630	COG5001	Diguanylate cyclase
At12D1_RS09640	COG0193	aminoacyl-tRNA hydrolase activity
At12D1_RS09650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D1_RS09675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
At12D1_RS09685	COG2857	Cytochrome c1
At12D1_RS09685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
At12D1_RS09705	COG1132	(ABC) transporter
At12D1_RS09710	COG1132	(ABC) transporter
At12D1_RS09720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
At12D1_RS09735	COG0408	coproporphyrinogen oxidase activity
At12D1_RS09750	COG0617	tRNA 3'-terminal CCA addition
At12D1_RS09765	COG0714	Associated with various cellular activities
At12D1_RS09785	COG0454	-acetyltransferase
At12D1_RS09800	COG0477	Major facilitator Superfamily
At12D1_RS09815	COG0435	Glutathione S-transferase
At12D1_RS09820	COG0494	nUDIX hydrolase
At12D1_RS09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
At12D1_RS09835	COG3135	benzoate transporter
At12D1_RS09860	COG0740	serine-type endopeptidase activity
At12D1_RS09875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
At12D1_RS09880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
At12D1_RS09910	COG4175	Glycine betaine
At12D1_RS09930	COG1435	thymidine kinase activity
At12D1_RS09955	COG1629	transport
At12D1_RS09955	COG4771	TonB-dependent receptor
At12D1_RS09965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
At12D1_RS09965	COG0512	Glutamine amidotransferase of anthranilate synthase
At12D1_RS09980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D1_RS09990	COG0366	Alpha amylase catalytic
At12D1_RS09995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS10015	COG1160	GTP binding
At12D1_RS10035	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
At12D1_RS10045	COG0024	Methionine aminopeptidase
At12D1_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS10070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D1_RS10080	COG0583	DNA-binding transcription factor activity
At12D1_RS10095	COG0402	S-adenosylhomocysteine deaminase activity
At12D1_RS10115	COG1309	transcriptional regulator
At12D1_RS10120	COG1686	Belongs to the peptidase S11 family
At12D1_RS10130	COG2351	hydroxyisourate hydrolase activity
At12D1_RS10135	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
At12D1_RS10150	COG3195	allantoin biosynthetic process
At12D1_RS10150	COG3648	Uricase
At12D1_RS10160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D1_RS10170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS10170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
At12D1_RS10180	COG0513	Belongs to the DEAD box helicase family
At12D1_RS10190	COG2259	Doxx family
At12D1_RS10195	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS10205	COG2308	Evidence 4 Homologs of previously reported genes of
At12D1_RS10215	COG1305	Transglutaminase-like
At12D1_RS10235	COG0588	phosphoglycerate mutase activity
At12D1_RS10245	COG4214	carbohydrate transport
At12D1_RS10255	COG4213	ABC transporter substrate-binding protein
At12D1_RS10370	COG0840	transmembrane signaling receptor activity
At12D1_RS10385	COG1410	methionine synthase
At12D1_RS10385	COG0646	methionine synthase
At12D1_RS10435	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS10450	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
At12D1_RS10470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D1_RS10485	COG2346	COG2346, Truncated hemoglobins
At12D1_RS10505	COG1309	transcriptional regulator
At12D1_RS10520	COG0494	nUDIX hydrolase
At12D1_RS10535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS10540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS10570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
At12D1_RS10575	COG0830	nickel cation binding
At12D1_RS10580	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
At12D1_RS10595	COG0804	urea catabolic process
At12D1_RS10600	COG1442	glycosyl transferase family 8
At12D1_RS10605	COG3755	Protein conserved in bacteria
At12D1_RS10615	COG0832	Belongs to the urease beta subunit family
At12D1_RS10620	COG3813	Protein conserved in bacteria
At12D1_RS10625	COG0831	urea catabolic process
At12D1_RS10630	COG0829	nickel cation binding
At12D1_RS10660	COG0559	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS10675	COG0174	glutamine synthetase
At12D1_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS10685	COG5002	protein histidine kinase activity
At12D1_RS10685	COG2198	Histidine kinase
At12D1_RS10685	COG0784	Response regulator, receiver
At12D1_RS10700	COG0726	polysaccharide deacetylase
At12D1_RS10735	COG1218	3'(2'),5'-bisphosphate nucleotidase
At12D1_RS10820	COG0564	pseudouridine synthase activity
At12D1_RS10835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D1_RS10845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
At12D1_RS10875	COG0346	lactoylglutathione lyase activity
At12D1_RS10885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
At12D1_RS10895	COG2832	Protein of unknown function (DUF454)
At12D1_RS10900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
At12D1_RS10905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS10910	COG4558	Periplasmic binding protein
At12D1_RS10920	COG3721	Heme iron utilization protein
At12D1_RS10935	COG3655	Transcriptional regulator
At12D1_RS10955	COG3657	addiction module killer protein
At12D1_RS10965	COG2205	protein histidine kinase activity
At12D1_RS11005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS11010	COG4605	iron ion homeostasis
At12D1_RS11015	COG4604	ABC transporter, ATP-binding protein
At12D1_RS11020	COG0783	Belongs to the Dps family
At12D1_RS11035	COG0840	transmembrane signaling receptor activity
At12D1_RS11035	COG2972	Histidine kinase
At12D1_RS11040	COG0656	L-ascorbic acid biosynthetic process
At12D1_RS11045	COG2814	Major facilitator Superfamily
At12D1_RS11055	COG0583	DNA-binding transcription factor activity
At12D1_RS11060	COG0657	acetylesterase activity
At12D1_RS11065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS11085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D1_RS11090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
At12D1_RS11095	COG0288	reversible hydration of carbon dioxide
At12D1_RS11105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
At12D1_RS11125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
At12D1_RS11130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D1_RS11135	COG0778	Nitroreductase
At12D1_RS11140	COG2267	carboxylic ester hydrolase activity
At12D1_RS11145	COG0251	oxidation-reduction process
At12D1_RS11150	COG1335	isochorismatase
At12D1_RS11155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS11165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS11180	COG1175	transmembrane transport
At12D1_RS11185	COG0395	ABC-type sugar transport system, permease component
At12D1_RS11190	COG3842	ATPase activity
At12D1_RS11195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS11205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D1_RS11220	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS11225	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS11230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS11235	COG0601	transmembrane transport
At12D1_RS11290	COG2159	amidohydrolase
At12D1_RS11295	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS11325	COG0745	RESPONSE REGULATOR receiver
At12D1_RS11335	COG1902	pentaerythritol trinitrate reductase activity
At12D1_RS11335	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D1_RS11340	COG3842	ATPase activity
At12D1_RS11350	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D1_RS11355	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D1_RS11360	COG0745	RESPONSE REGULATOR receiver
At12D1_RS11370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
At12D1_RS11375	COG0583	DNA-binding transcription factor activity
At12D1_RS11380	COG1278	Cold shock
At12D1_RS11390	COG2130	NADP-dependent
At12D1_RS11400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS11405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS11430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D1_RS11455	COG2144	transferase activity, transferring acyl groups
At12D1_RS11460	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS11480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
At12D1_RS11490	COG2814	Major facilitator Superfamily
At12D1_RS11495	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS11515	COG3485	protocatechuate 3,4-dioxygenase
At12D1_RS11555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS11560	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS11565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS11595	COG4977	sequence-specific DNA binding
At12D1_RS11595	COG1917	Cupin 2, conserved barrel domain protein
At12D1_RS11645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS11655	COG1294	oxidase, subunit
At12D1_RS11660	COG1271	oxidase subunit
At12D1_RS11675	COG1063	alcohol dehydrogenase
At12D1_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS11685	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS11690	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS11695	COG1129	ABC transporter
At12D1_RS11700	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS11705	COG1609	Transcriptional regulator
At12D1_RS11710	COG3415	Transposase
At12D1_RS11725	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS11730	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS11735	COG1129	ABC transporter
At12D1_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS11750	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
At12D1_RS11755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS11760	COG1940	carbohydrate kinase activity
At12D1_RS11765	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS11770	COG1129	ABC transporter
At12D1_RS11775	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS11780	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS11790	COG0840	transmembrane signaling receptor activity
At12D1_RS11790	COG2972	Histidine kinase
At12D1_RS11800	COG1126	abc transporter atp-binding protein
At12D1_RS11805	COG0765	amino acid transport
At12D1_RS11810	COG2963	transposase activity
At12D1_RS11815	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS11820	COG2433	Pfam Transposase IS66
At12D1_RS11830	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
At12D1_RS11835	COG2301	Belongs to the HpcH HpaI aldolase family
At12D1_RS11895	COG2948	multi-organism process
At12D1_RS11935	COG0006	proline dipeptidase activity
At12D1_RS11940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
At12D1_RS11960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
At12D1_RS11970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
At12D1_RS11985	COG5489	Protein of unknown function (DUF736)
At12D1_RS12070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D1_RS12075	COG1309	transcriptional regulator
At12D1_RS12080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS12085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D1_RS12095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
At12D1_RS12100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
At12D1_RS12120	COG0583	DNA-binding transcription factor activity
At12D1_RS12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS12130	COG0725	ABC transporter, periplasmic molybdate-binding protein
At12D1_RS12135	COG4149	molybdate abc transporter
At12D1_RS12140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
At12D1_RS12155	COG2022	thiamine diphosphate biosynthetic process
At12D1_RS12170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
At12D1_RS12175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D1_RS12185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D1_RS12205	COG1132	(ABC) transporter
At12D1_RS12210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D1_RS12255	COG4166	transmembrane transport
At12D1_RS12260	COG0601	transmembrane transport
At12D1_RS12265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS12280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D1_RS12285	COG3142	Participates in the control of copper homeostasis
At12D1_RS12290	COG2814	Major facilitator Superfamily
At12D1_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS12310	COG1737	Transcriptional regulator
At12D1_RS12320	COG3842	ATPase activity
At12D1_RS12330	COG0395	ABC-type sugar transport system, permease component
At12D1_RS12350	COG2188	Transcriptional regulator
At12D1_RS12355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
At12D1_RS12360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
At12D1_RS12365	COG1940	carbohydrate kinase activity
At12D1_RS12375	COG0671	phosphoesterase, PA-phosphatase related
At12D1_RS12380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
At12D1_RS12385	COG0156	8-amino-7-oxononanoate synthase activity
At12D1_RS12395	COG0729	surface antigen
At12D1_RS12405	COG0835	chemotaxis
At12D1_RS12415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
At12D1_RS12420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
At12D1_RS12425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
At12D1_RS12430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
At12D1_RS12435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
At12D1_RS12440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
At12D1_RS12455	COG4974	Belongs to the 'phage' integrase family
At12D1_RS12480	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS12490	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D1_RS12495	COG0567	Dehydrogenase, E1 component
At12D1_RS12500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
At12D1_RS12505	COG0045	succinate-CoA ligase (ADP-forming) activity
At12D1_RS12510	COG0039	L-malate dehydrogenase activity
At12D1_RS12515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
At12D1_RS12550	COG2264	protein methyltransferase activity
At12D1_RS12565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
At12D1_RS12570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
At12D1_RS12575	COG0181	hydroxymethylbilane synthase activity
At12D1_RS12610	COG1872	DUF167
At12D1_RS12615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
At12D1_RS12625	COG1217	gtp-binding protein TYPA
At12D1_RS12630	COG0339	signal peptide processing
At12D1_RS12635	COG1846	Transcriptional regulator
At12D1_RS12645	COG0137	argininosuccinate synthase activity
At12D1_RS12655	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS12660	COG1122	ATPase activity
At12D1_RS12665	COG4120	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS12675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
At12D1_RS12690	COG2154	pterin-4-alpha-carbinolamine dehydratase
At12D1_RS12695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
At12D1_RS12700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
At12D1_RS12710	COG4181	ATPase activity
At12D1_RS12720	COG0670	Belongs to the BI1 family
At12D1_RS12735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
At12D1_RS12740	COG4133	protoheme IX ABC transporter activity
At12D1_RS12750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D1_RS12755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D1_RS12780	COG2917	probably involved in intracellular septation
At12D1_RS12785	COG0552	protein localization to endoplasmic reticulum
At12D1_RS12790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D1_RS12795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
At12D1_RS12810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
At12D1_RS12815	COG0287	Prephenate dehydrogenase
At12D1_RS12815	COG1605	Chorismate mutase
At12D1_RS12820	COG0228	four-way junction DNA binding
At12D1_RS12825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
At12D1_RS12830	COG0336	Belongs to the RNA methyltransferase TrmD family
At12D1_RS12840	COG0335	large ribosomal subunit rRNA binding
At12D1_RS12845	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D1_RS12850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS12870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
At12D1_RS12895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
At12D1_RS12915	COG0488	(ABC) transporter
At12D1_RS12925	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
At12D1_RS12935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
At12D1_RS12940	COG0142	geranyltranstransferase activity
At12D1_RS12945	COG2885	chlorophyll binding
At12D1_RS12950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
At12D1_RS12955	COG2223	nitrite transmembrane transporter activity
At12D1_RS12960	COG1349	DNA-binding transcription factor activity
At12D1_RS12965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
At12D1_RS12970	COG2197	response regulator
At12D1_RS12975	COG1132	(ABC) transporter
At12D1_RS12985	COG3459	Glycosyltransferase 36 associated
At12D1_RS12990	COG1473	amidohydrolase
At12D1_RS13000	COG0579	oxidoreductase
At12D1_RS13010	COG0129	dihydroxy-acid dehydratase activity
At12D1_RS13015	COG2084	Dehydrogenase
At12D1_RS13020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS13025	COG0277	FAD linked oxidase domain protein
At12D1_RS13030	COG1609	Transcriptional regulator
At12D1_RS13040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D1_RS13045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D1_RS13050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D1_RS13055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D1_RS13065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
At12D1_RS13070	COG0495	leucyl-tRNA aminoacylation
At12D1_RS13085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
At12D1_RS13090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
At12D1_RS13105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D1_RS13110	COG1946	Acyl-CoA thioesterase
At12D1_RS13115	COG0347	Belongs to the P(II) protein family
At12D1_RS13120	COG0004	ammonium transporteR
At12D1_RS13125	COG1674	ftsk spoiiie
At12D1_RS13130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
At12D1_RS13145	COG0745	RESPONSE REGULATOR receiver
At12D1_RS13155	COG1329	Transcriptional regulator
At12D1_RS13165	COG2270	Major facilitator Superfamily
At12D1_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS13195	COG0494	nUDIX hydrolase
At12D1_RS13200	COG2861	carbohydrate metabolic process
At12D1_RS13205	COG0793	Belongs to the peptidase S41A family
At12D1_RS13215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
At12D1_RS13220	COG0799	negative regulation of ribosome biogenesis
At12D1_RS13225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
At12D1_RS13230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
At12D1_RS13235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
At12D1_RS13240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
At12D1_RS13255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
At12D1_RS13260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
At12D1_RS13290	COG0066	3-isopropylmalate dehydratase activity
At12D1_RS13295	COG0473	3-isopropylmalate dehydrogenase activity
At12D1_RS13300	COG1858	cytochrome C peroxidase
At12D1_RS13305	COG1797	cobyrinic acid a,c-diamide synthase activity
At12D1_RS13315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
At12D1_RS13380	COG1492	cobalamin metabolic process
At12D1_RS13395	COG4948	Mandelate Racemase Muconate Lactonizing
At12D1_RS13400	COG3254	rhamnose metabolic process
At12D1_RS13410	COG1063	alcohol dehydrogenase
At12D1_RS13435	COG1129	ABC transporter
At12D1_RS13440	COG2186	Transcriptional regulator
At12D1_RS13445	COG2721	sulfolactate sulfo-lyase activity
At12D1_RS13450	COG0138	bifunctional purine biosynthesis protein purh
At12D1_RS13460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
At12D1_RS13460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D1_RS13465	COG0501	Belongs to the peptidase M48B family
At12D1_RS13485	COG0357	Ribosomal RNA small subunit methyltransferase G
At12D1_RS13490	COG0445	tRNA wobble uridine modification
At12D1_RS13495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
At12D1_RS13500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
At12D1_RS13505	COG1981	membrane
At12D1_RS13510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
At12D1_RS13515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
At12D1_RS13520	COG0424	maF-like protein
At12D1_RS13525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D1_RS13530	COG0237	dephospho-CoA kinase activity
At12D1_RS13540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
At12D1_RS13545	COG3030	protein affecting phage T7 exclusion by the F plasmid
At12D1_RS13555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
At12D1_RS13580	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D1_RS13595	COG0135	phosphoribosylanthranilate isomerase activity
At12D1_RS13600	COG0133	tryptophan synthase activity
At12D1_RS13605	COG0159	tryptophan synthase activity
At12D1_RS13610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
At12D1_RS13625	COG1074	ATP-dependent DNA helicase activity
At12D1_RS13635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
At12D1_RS13640	COG0802	atpase or kinase
At12D1_RS13645	COG2205	protein histidine kinase activity
At12D1_RS13655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
At12D1_RS13660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D1_RS13665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D1_RS13665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
At12D1_RS13670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
At12D1_RS13675	COG0642	Histidine kinase
At12D1_RS13680	COG0745	RESPONSE REGULATOR receiver
At12D1_RS13685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
At12D1_RS13695	COG1652	LysM domain
At12D1_RS13700	COG1072	(Pantothenic acid kinase))
At12D1_RS13705	COG0140	phosphoribosyl-ATP diphosphatase activity
At12D1_RS13710	COG0107	imidazoleglycerol-phosphate synthase activity
At12D1_RS13715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
At12D1_RS13720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
At12D1_RS13730	COG0131	Imidazoleglycerol-phosphate dehydratase
At12D1_RS13735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
At12D1_RS13740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
At12D1_RS13750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
At12D1_RS13765	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
At12D1_RS13775	COG1643	Atp-dependent helicase
At12D1_RS13850	COG1072	(Pantothenic acid kinase))
At12D1_RS13860	COG1780	Probably involved in ribonucleotide reductase function
At12D1_RS13880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
At12D1_RS13910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS13920	COG2813	Specifically methylates the guanine in position
At12D1_RS13925	COG1185	polyribonucleotide nucleotidyltransferase activity
At12D1_RS13930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
At12D1_RS13935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
At12D1_RS13940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
At12D1_RS13945	COG3064	Membrane
At12D1_RS13945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
At12D1_RS13960	COG0779	Required for maturation of 30S ribosomal subunits
At12D1_RS13965	COG2814	Major facilitator Superfamily
At12D1_RS13970	COG2951	lytic endotransglycosylase activity
At12D1_RS13975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
At12D1_RS13985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
At12D1_RS13990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
At12D1_RS14005	COG2816	NAD+ diphosphatase activity
At12D1_RS14010	COG0077	Prephenate dehydratase
At12D1_RS14010	COG1605	Chorismate mutase
At12D1_RS14015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
At12D1_RS14020	COG3474	cytochrome
At12D1_RS14030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D1_RS14035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
At12D1_RS14045	COG1278	Cold shock
At12D1_RS14050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D1_RS14060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D1_RS14060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D1_RS14065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
At12D1_RS14100	COG2900	Belongs to the SlyX family
At12D1_RS14110	COG0484	heat shock protein binding
At12D1_RS14115	COG0443	Heat shock 70 kDa protein
At12D1_RS14135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D1_RS14140	COG1744	ABC transporter substrate-binding protein PnrA-like
At12D1_RS14145	COG3845	ABC transporter
At12D1_RS14150	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS14155	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS14160	COG0295	cytidine deaminase activity
At12D1_RS14165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
At12D1_RS14170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
At12D1_RS14175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
At12D1_RS14185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
At12D1_RS14190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
At12D1_RS14195	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
At12D1_RS14205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
At12D1_RS14210	COG1845	cytochrome c oxidase, subunit III
At12D1_RS14215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D1_RS14220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D1_RS14225	COG0477	Major facilitator Superfamily
At12D1_RS14235	COG0070	glutamate synthase
At12D1_RS14235	COG0067	glutamate synthase
At12D1_RS14235	COG0069	glutamate synthase activity
At12D1_RS14240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
At12D1_RS14255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D1_RS14265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D1_RS14300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS14320	COG0848	biopolymer transport protein
At12D1_RS14330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D1_RS14345	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D1_RS14350	COG3454	Phosphonate metabolism
At12D1_RS14355	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D1_RS14365	COG3639	organic phosphonate transmembrane transporter activity
At12D1_RS14370	COG3639	organic phosphonate transmembrane transporter activity
At12D1_RS14380	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
At12D1_RS14390	COG4778	phosphonate C-P lyase system protein PhnL
At12D1_RS14395	COG4107	phosphonate C-P lyase system protein PhnK
At12D1_RS14400	COG3627	carbon phosphorus lyase activity
At12D1_RS14405	COG3626	phosphonate metabolism
At12D1_RS14410	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
At12D1_RS14415	COG3624	Phosphonate C-P lyase system protein PhnG
At12D1_RS14420	COG2188	Transcriptional regulator
At12D1_RS14425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
At12D1_RS14430	COG0837	glucose binding
At12D1_RS14435	COG1803	Methylglyoxal synthase
At12D1_RS14440	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
At12D1_RS14445	COG4166	transmembrane transport
At12D1_RS14450	COG4174	ABC transporter (Permease)
At12D1_RS14455	COG4239	(ABC) transporter, permease
At12D1_RS14460	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS14465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS14470	COG0174	glutamine synthetase
At12D1_RS14475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS14480	COG3265	gluconokinase activity
At12D1_RS14485	COG1174	glycine betaine transport
At12D1_RS14490	COG1125	glycine betaine transport
At12D1_RS14495	COG1174	glycine betaine transport
At12D1_RS14500	COG1732	Glycine betaine
At12D1_RS14510	COG1959	2 iron, 2 sulfur cluster binding
At12D1_RS14515	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D1_RS14520	COG0501	Belongs to the peptidase M48B family
At12D1_RS14525	COG4269	membrane
At12D1_RS14540	COG0697	spore germination
At12D1_RS14555	COG0791	NLP P60 protein
At12D1_RS14565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
At12D1_RS14570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D1_RS14605	COG4964	Belongs to the GSP D family
At12D1_RS14655	COG3422	double-strand break repair
At12D1_RS14660	COG3757	hydrolase, family 25
At12D1_RS14665	COG0697	spore germination
At12D1_RS14670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D1_RS14685	COG0492	ferredoxin-NADP+ reductase activity
At12D1_RS14700	COG0481	GTPase activity
At12D1_RS14705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS14720	COG1396	sequence-specific DNA binding
At12D1_RS14735	COG1917	Cupin 2, conserved barrel domain protein
At12D1_RS14735	COG2169	Transcriptional regulator
At12D1_RS14740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D1_RS14765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
At12D1_RS14770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
At12D1_RS14775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
At12D1_RS14785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
At12D1_RS14790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D1_RS14790	COG0072	phenylalanine-tRNA ligase activity
At12D1_RS14795	COG0667	Aldo Keto reductase
At12D1_RS14815	COG4977	sequence-specific DNA binding
At12D1_RS14840	COG1570	exodeoxyribonuclease VII activity
At12D1_RS14845	COG4948	Mandelate Racemase Muconate Lactonizing
At12D1_RS14855	COG1846	Transcriptional regulator
At12D1_RS14860	COG0697	spore germination
At12D1_RS14865	COG2309	aminopeptidase activity
At12D1_RS14875	COG1393	Belongs to the ArsC family
At12D1_RS14895	COG1309	transcriptional regulator
At12D1_RS14905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
At12D1_RS14905	COG0519	Catalyzes the synthesis of GMP from XMP
At12D1_RS14920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
At12D1_RS14950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
At12D1_RS14960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
At12D1_RS14970	COG1968	undecaprenyl-diphosphatase activity
At12D1_RS14995	COG0284	orotidine-5'-phosphate decarboxylase activity
At12D1_RS15005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D1_RS15015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
At12D1_RS15020	COG0792	nuclease activity
At12D1_RS15035	COG1175	transmembrane transport
At12D1_RS15040	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15045	COG3842	ATPase activity
At12D1_RS15055	COG0189	ligase activity
At12D1_RS15065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
At12D1_RS15070	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS15075	COG0756	dUTP diphosphatase activity
At12D1_RS15080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
At12D1_RS15085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
At12D1_RS15100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
At12D1_RS15105	COG2226	methyltransferase
At12D1_RS15110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
At12D1_RS15115	COG1024	Enoyl-CoA hydratase
At12D1_RS15120	COG0268	Binds directly to 16S ribosomal RNA
At12D1_RS15155	COG4106	trans-aconitate 2-methyltransferase activity
At12D1_RS15180	COG1278	Cold shock
At12D1_RS15215	COG0411	ABC transporter
At12D1_RS15220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
At12D1_RS15225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS15230	COG1454	alcohol dehydrogenase
At12D1_RS15235	COG0747	negative chemotaxis
At12D1_RS15240	COG0601	transmembrane transport
At12D1_RS15250	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS15255	COG1349	DNA-binding transcription factor activity
At12D1_RS15260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D1_RS15285	COG4302	ethanolamine ammonia-lyase activity
At12D1_RS15290	COG0025	NhaP-type Na H and K H
At12D1_RS15295	COG4106	trans-aconitate 2-methyltransferase activity
At12D1_RS15305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS15310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS15315	COG0601	transmembrane transport
At12D1_RS15340	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS15345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
At12D1_RS15360	COG2814	Major facilitator Superfamily
At12D1_RS15380	COG0596	Alpha beta hydrolase
At12D1_RS15395	COG1764	response to oxidative stress
At12D1_RS15405	COG0596	Alpha beta hydrolase
At12D1_RS15420	COG0783	Belongs to the Dps family
At12D1_RS15425	COG0243	molybdopterin cofactor binding
At12D1_RS15435	COG4566	intracellular signal transduction
At12D1_RS15440	COG4566	intracellular signal transduction
At12D1_RS15450	COG2140	Oxalate decarboxylase
At12D1_RS15465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D1_RS15465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D1_RS15470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D1_RS15480	COG1414	Transcriptional regulator
At12D1_RS15490	COG0318	PFAM AMP-dependent synthetase and ligase
At12D1_RS15495	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS15515	COG1522	sequence-specific DNA binding
At12D1_RS15540	COG0628	permease
At12D1_RS15550	COG2235	arginine
At12D1_RS15585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D1_RS15595	COG0702	epimerase
At12D1_RS15600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D1_RS15605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS15610	COG0745	RESPONSE REGULATOR receiver
At12D1_RS15615	COG5002	protein histidine kinase activity
At12D1_RS15630	COG2233	PERMEase
At12D1_RS15685	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15690	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D1_RS15700	COG3842	ATPase activity
At12D1_RS15740	COG1653	transport
At12D1_RS15745	COG1175	transmembrane transport
At12D1_RS15750	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15755	COG3842	ATPase activity
At12D1_RS15770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS15775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS15780	COG1116	anion transmembrane transporter activity
At12D1_RS15785	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15790	COG1175	transmembrane transport
At12D1_RS15820	COG1609	Transcriptional regulator
At12D1_RS15835	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS15840	COG3842	ATPase activity
At12D1_RS15845	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15850	COG1175	transmembrane transport
At12D1_RS15855	COG1653	transport
At12D1_RS15860	COG1309	transcriptional regulator
At12D1_RS15865	COG0673	inositol 2-dehydrogenase activity
At12D1_RS15880	COG0673	inositol 2-dehydrogenase activity
At12D1_RS15885	COG1278	Cold shock
At12D1_RS15895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D1_RS15915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D1_RS15920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D1_RS15935	COG3842	ATPase activity
At12D1_RS15940	COG0395	ABC-type sugar transport system, permease component
At12D1_RS15945	COG1175	transmembrane transport
At12D1_RS15955	COG3618	amidohydrolase
At12D1_RS15960	COG4948	Mandelate Racemase Muconate Lactonizing
At12D1_RS15965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS15975	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
At12D1_RS15980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS15985	COG2186	Transcriptional regulator
At12D1_RS16000	COG0667	Aldo Keto reductase
At12D1_RS16035	COG4977	sequence-specific DNA binding
At12D1_RS16040	COG2223	nitrite transmembrane transporter activity
At12D1_RS16045	COG1609	Transcriptional regulator
At12D1_RS16050	COG1063	alcohol dehydrogenase
At12D1_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS16070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS16075	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
At12D1_RS16080	COG1175	transmembrane transport
At12D1_RS16085	COG0395	ABC-type sugar transport system, permease component
At12D1_RS16100	COG0395	ABC-type sugar transport system, permease component
At12D1_RS16110	COG2182	Extracellular solute-binding protein
At12D1_RS16115	COG0626	cystathionine gamma-synthase activity
At12D1_RS16130	COG0454	-acetyltransferase
At12D1_RS16135	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D1_RS16145	COG1121	(ABC) transporter
At12D1_RS16150	COG0523	cobalamin synthesis protein
At12D1_RS16165	COG0523	cobalamin synthesis protein
At12D1_RS16170	COG1653	transport
At12D1_RS16175	COG1175	transmembrane transport
At12D1_RS16180	COG0395	ABC-type sugar transport system, permease component
At12D1_RS16185	COG3842	ATPase activity
At12D1_RS16195	COG3047	cAMP biosynthetic process
At12D1_RS16220	COG0583	DNA-binding transcription factor activity
At12D1_RS16225	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS16230	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS16235	COG1129	ABC transporter
At12D1_RS16245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D1_RS16250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS16260	COG3257	ureidoglycine aminohydrolase activity
At12D1_RS16270	COG5001	Diguanylate cyclase
At12D1_RS16275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D1_RS16285	COG0747	negative chemotaxis
At12D1_RS16290	COG0601	transmembrane transport
At12D1_RS16295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS16305	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS16310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
At12D1_RS16325	COG0346	lactoylglutathione lyase activity
At12D1_RS16335	COG0129	dihydroxy-acid dehydratase activity
At12D1_RS16345	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS16350	COG1129	ABC transporter
At12D1_RS16355	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS16360	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS16365	COG2186	Transcriptional regulator
At12D1_RS16380	COG2226	methyltransferase
At12D1_RS16385	COG0587	DNA-directed DNA polymerase activity
At12D1_RS16415	COG0673	inositol 2-dehydrogenase activity
At12D1_RS16425	COG3842	ATPase activity
At12D1_RS16430	COG0395	ABC-type sugar transport system, permease component
At12D1_RS16435	COG1175	transmembrane transport
At12D1_RS16440	COG1653	transport
At12D1_RS16450	COG0673	inositol 2-dehydrogenase activity
At12D1_RS16465	COG5001	Diguanylate cyclase
At12D1_RS16480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
At12D1_RS16485	COG2894	cell division
At12D1_RS16490	COG0850	regulation of cytokinetic process
At12D1_RS16495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D1_RS16500	COG2186	Transcriptional regulator
At12D1_RS16505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D1_RS16515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D1_RS16520	COG1063	alcohol dehydrogenase
At12D1_RS16525	COG1312	Catalyzes the dehydration of D-mannonate
At12D1_RS16545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D1_RS16550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D1_RS16550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D1_RS16555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS16570	COG0625	glutathione transferase activity
At12D1_RS16575	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS16580	COG1921	L-seryl-tRNASec selenium transferase activity
At12D1_RS16595	COG3964	amidohydrolase
At12D1_RS16605	COG0601	transmembrane transport
At12D1_RS16610	COG0747	negative chemotaxis
At12D1_RS16615	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS16650	COG4989	oxidoreductase activity
At12D1_RS16660	COG2188	Transcriptional regulator
At12D1_RS16665	COG3842	ATPase activity
At12D1_RS16670	COG1653	transport
At12D1_RS16675	COG1175	transmembrane transport
At12D1_RS16680	COG0395	ABC-type sugar transport system, permease component
At12D1_RS16685	COG1501	Belongs to the glycosyl hydrolase 31 family
At12D1_RS16695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS16700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS16705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
At12D1_RS16710	COG0352	thiamine-phosphate diphosphorylase activity
At12D1_RS16715	COG0351	phosphomethylpyrimidine kinase
At12D1_RS16720	COG1522	sequence-specific DNA binding
At12D1_RS16725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D1_RS16730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS16745	COG2204	response regulator
At12D1_RS16750	COG4191	Histidine kinase
At12D1_RS16755	COG1301	dicarboxylic acid transport
At12D1_RS16760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D1_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS16775	COG1473	amidohydrolase
At12D1_RS16795	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS16805	COG2942	2-epimerase
At12D1_RS16830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS16840	COG2197	response regulator
At12D1_RS16870	COG3307	-O-antigen
At12D1_RS16875	COG1596	polysaccharide export
At12D1_RS16880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
At12D1_RS16895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D1_RS16900	COG0840	transmembrane signaling receptor activity
At12D1_RS16905	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS16925	COG2094	Belongs to the DNA glycosylase MPG family
At12D1_RS16940	COG1609	Transcriptional regulator
At12D1_RS16945	COG1653	transport
At12D1_RS16960	COG3842	ATPase activity
At12D1_RS16970	COG0673	inositol 2-dehydrogenase activity
At12D1_RS16975	COG0602	queuosine metabolic process
At12D1_RS16980	COG0720	synthase
At12D1_RS16985	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
At12D1_RS16990	COG0673	inositol 2-dehydrogenase activity
At12D1_RS17005	COG0395	ABC-type sugar transport system, permease component
At12D1_RS17010	COG1175	transmembrane transport
At12D1_RS17035	COG0583	DNA-binding transcription factor activity
At12D1_RS17040	COG0280	phosphate acetyltransferase
At12D1_RS17040	COG0281	malic enzyme
At12D1_RS17055	COG0765	amino acid transport
At12D1_RS17060	COG1126	abc transporter atp-binding protein
At12D1_RS17065	COG2079	MmgE PrpD family protein
At12D1_RS17070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS17100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D1_RS17110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D1_RS17115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
At12D1_RS17120	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS17125	COG1129	ABC transporter
At12D1_RS17140	COG1473	amidohydrolase
At12D1_RS17145	COG0747	negative chemotaxis
At12D1_RS17160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS17165	COG0601	transmembrane transport
At12D1_RS17170	COG0583	DNA-binding transcription factor activity
At12D1_RS17175	COG1446	asparaginase
At12D1_RS17190	COG0747	negative chemotaxis
At12D1_RS17210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS17215	COG0601	transmembrane transport
At12D1_RS17220	COG2197	response regulator
At12D1_RS17225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D1_RS17230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS17245	COG0395	ABC-type sugar transport system, permease component
At12D1_RS17250	COG1175	transmembrane transport
At12D1_RS17260	COG0673	inositol 2-dehydrogenase activity
At12D1_RS17265	COG0673	inositol 2-dehydrogenase activity
At12D1_RS17285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS17290	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D1_RS17310	COG1595	DNA-templated transcription, initiation
At12D1_RS17315	COG1120	ATPase activity
At12D1_RS17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS17335	COG2226	methyltransferase
At12D1_RS17345	COG1120	ATPase activity
At12D1_RS17350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS17370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D1_RS17395	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS17400	COG0473	3-isopropylmalate dehydrogenase activity
At12D1_RS17405	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS17410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS17445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS17450	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS17455	COG1522	sequence-specific DNA binding
At12D1_RS17465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS17480	COG0583	DNA-binding transcription factor activity
At12D1_RS17490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS17495	COG1126	abc transporter atp-binding protein
At12D1_RS17505	COG1473	amidohydrolase
At12D1_RS17510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17520	COG1959	2 iron, 2 sulfur cluster binding
At12D1_RS17530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D1_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17565	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS17575	COG0747	negative chemotaxis
At12D1_RS17590	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS17600	COG0667	Aldo Keto reductase
At12D1_RS17610	COG0583	DNA-binding transcription factor activity
At12D1_RS17615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17620	COG4166	transmembrane transport
At12D1_RS17630	COG0747	negative chemotaxis
At12D1_RS17635	COG1473	amidohydrolase
At12D1_RS17640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS17680	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS17685	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS17695	COG0601	transmembrane transport
At12D1_RS17705	COG2186	Transcriptional regulator
At12D1_RS17720	COG0300	oxidoreductase activity
At12D1_RS17730	COG3453	Protein conserved in bacteria
At12D1_RS17730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D1_RS17735	COG0640	Transcriptional regulator
At12D1_RS17745	COG2391	methyltransferase activity
At12D1_RS17750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
At12D1_RS17770	COG0022	dehydrogenase e1 component
At12D1_RS17780	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS17785	COG0183	Belongs to the thiolase family
At12D1_RS17795	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS17800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D1_RS17820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
At12D1_RS17825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
At12D1_RS17830	COG4952	isomerase
At12D1_RS17835	COG3347	Dehydrogenase
At12D1_RS17835	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS17840	COG1349	DNA-binding transcription factor activity
At12D1_RS17855	COG1129	ABC transporter
At12D1_RS17860	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS17865	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS17870	COG3254	rhamnose metabolic process
At12D1_RS17885	COG2264	protein methyltransferase activity
At12D1_RS17890	COG5001	Diguanylate cyclase
At12D1_RS17905	COG4335	DNA alkylation repair
At12D1_RS17910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D1_RS17915	COG4208	sulfate ABC transporter
At12D1_RS17925	COG4150	thiosulfate binding
At12D1_RS17930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
At12D1_RS17950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D1_RS17960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D1_RS17970	COG1040	competence protein
At12D1_RS17975	COG2226	methyltransferase
At12D1_RS17990	COG0494	nUDIX hydrolase
At12D1_RS18000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
At12D1_RS18005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
At12D1_RS18010	COG0653	protein targeting
At12D1_RS18015	COG0697	spore germination
At12D1_RS18080	COG2244	polysaccharide biosynthetic process
At12D1_RS18095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D1_RS18105	COG3206	protein involved in exopolysaccharide biosynthesis
At12D1_RS18105	COG0489	protein tyrosine kinase activity
At12D1_RS18125	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS18130	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS18140	COG2963	transposase activity
At12D1_RS18145	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS18150	COG2433	Pfam Transposase IS66
At12D1_RS18165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D1_RS18170	COG2273	Hydrolase Family 16
At12D1_RS18170	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
At12D1_RS18185	COG3842	ATPase activity
At12D1_RS18190	COG3833	ABC-type maltose transport systems, permease component
At12D1_RS18245	COG1396	sequence-specific DNA binding
At12D1_RS18255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
At12D1_RS18260	COG1129	ABC transporter
At12D1_RS18265	COG4214	carbohydrate transport
At12D1_RS18270	COG4213	ABC transporter substrate-binding protein
At12D1_RS18285	COG0346	lactoylglutathione lyase activity
At12D1_RS18290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
At12D1_RS18290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
At12D1_RS18295	COG4770	biotin carboxylase activity
At12D1_RS18310	COG0625	glutathione transferase activity
At12D1_RS18315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D1_RS18320	COG1396	sequence-specific DNA binding
At12D1_RS18320	COG3800	Transcriptional regulator
At12D1_RS18330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D1_RS18340	COG0300	oxidoreductase activity
At12D1_RS18350	COG2096	Adenosyltransferase
At12D1_RS18360	COG2086	electron transfer activity
At12D1_RS18370	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D1_RS18380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
At12D1_RS18385	COG0165	Argininosuccinate lyase
At12D1_RS18420	COG2884	Cell division ATP-binding protein ftsE
At12D1_RS18440	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
At12D1_RS18450	COG0287	Prephenate dehydrogenase
At12D1_RS18455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D1_RS18460	COG2226	methyltransferase
At12D1_RS18465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D1_RS18480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
At12D1_RS18485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
At12D1_RS18525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
At12D1_RS18530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
At12D1_RS18545	COG4974	Belongs to the 'phage' integrase family
At12D1_RS18550	COG0825	malonyl-CoA metabolic process
At12D1_RS18555	COG3034	peptidoglycan biosynthetic process
At12D1_RS18560	COG0425	Belongs to the sulfur carrier protein TusA family
At12D1_RS18560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
At12D1_RS18570	COG0523	cobalamin synthesis protein
At12D1_RS18575	COG1686	Belongs to the peptidase S11 family
At12D1_RS18580	COG1473	amidohydrolase
At12D1_RS18590	COG4953	penicillin-binding protein 1C
At12D1_RS18595	COG2373	Large extracellular alpha-helical protein
At12D1_RS18600	COG2835	tetraacyldisaccharide 4'-kinase activity
At12D1_RS18630	COG0482	sulfurtransferase activity
At12D1_RS18645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D1_RS18660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D1_RS18665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
At12D1_RS18670	COG0037	tRNA processing
At12D1_RS18680	COG2885	chlorophyll binding
At12D1_RS18685	COG0823	Involved in the tonB-independent uptake of proteins
At12D1_RS18705	COG0824	Thioesterase
At12D1_RS18715	COG0494	nUDIX hydrolase
At12D1_RS18730	COG2255	four-way junction helicase activity
At12D1_RS18735	COG0632	four-way junction helicase activity
At12D1_RS18740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
At12D1_RS18745	COG0840	transmembrane signaling receptor activity
At12D1_RS18750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS18755	COG0217	transcriptional regulatory protein
At12D1_RS18770	COG1692	metallophosphoesterase
At12D1_RS18780	COG1253	flavin adenine dinucleotide binding
At12D1_RS18830	COG0126	phosphoglycerate kinase activity
At12D1_RS18835	COG3588	fructose-bisphosphate aldolase
At12D1_RS18855	COG0254	rRNA binding
At12D1_RS18860	COG1132	(ABC) transporter
At12D1_RS18885	COG0483	inositol monophosphate 1-phosphatase activity
At12D1_RS18915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
At12D1_RS18920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
At12D1_RS18925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
At12D1_RS18930	COG0457	Tetratricopeptide repeat
At12D1_RS18935	COG3750	Belongs to the UPF0335 family
At12D1_RS18955	COG0469	pyruvate kinase activity
At12D1_RS18960	COG3108	Peptidase M15
At12D1_RS18965	COG2204	response regulator
At12D1_RS18970	COG1164	Oligoendopeptidase f
At12D1_RS18975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D1_RS18985	COG5310	Homospermidine synthase
At12D1_RS18995	COG0737	Belongs to the 5'-nucleotidase family
At12D1_RS19000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
At12D1_RS19005	COG0330	HflC and HflK could
At12D1_RS19035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D1_RS19040	COG2951	lytic endotransglycosylase activity
At12D1_RS19055	COG2205	protein histidine kinase activity
At12D1_RS19065	COG0070	glutamate synthase
At12D1_RS19065	COG0067	glutamate synthase
At12D1_RS19065	COG0069	glutamate synthase activity
At12D1_RS19080	COG2205	protein histidine kinase activity
At12D1_RS19085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
At12D1_RS19090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
At12D1_RS19095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
At12D1_RS19105	COG0252	asparaginase activity
At12D1_RS19115	COG1027	Aspartate ammonia-lyase
At12D1_RS19120	COG2186	Transcriptional regulator
At12D1_RS19140	COG1309	transcriptional regulator
At12D1_RS19160	COG4176	ABC-type proline glycine betaine transport system permease component
At12D1_RS19165	COG4175	Glycine betaine
At12D1_RS19165	COG0517	IMP dehydrogenase activity
At12D1_RS19170	COG2986	histidine ammonia-lyase
At12D1_RS19175	COG1609	Transcriptional regulator
At12D1_RS19195	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS19200	COG0673	inositol 2-dehydrogenase activity
At12D1_RS19205	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS19220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS19230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS19235	COG0601	transmembrane transport
At12D1_RS19240	COG0747	negative chemotaxis
At12D1_RS19250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D1_RS19255	COG1454	alcohol dehydrogenase
At12D1_RS19300	COG2308	Evidence 4 Homologs of previously reported genes of
At12D1_RS19300	COG2307	Protein conserved in bacteria
At12D1_RS19315	COG0488	(ABC) transporter
At12D1_RS19320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D1_RS19325	COG2186	Transcriptional regulator
At12D1_RS19340	COG1175	transmembrane transport
At12D1_RS19345	COG0395	ABC-type sugar transport system, permease component
At12D1_RS19355	COG3842	ATPase activity
At12D1_RS19380	COG1304	FMN binding
At12D1_RS19395	COG1063	alcohol dehydrogenase
At12D1_RS19400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D1_RS19405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS19415	COG0765	amino acid transport
At12D1_RS19420	COG0765	amino acid transport
At12D1_RS19425	COG4221	oxidoreductase activity
At12D1_RS19430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D1_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS19440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS19455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D1_RS19470	COG0697	spore germination
At12D1_RS19475	COG0697	spore germination
At12D1_RS19480	COG0511	ligase activity, forming carbon-carbon bonds
At12D1_RS19485	COG0439	Biotin carboxylase
At12D1_RS19495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
At12D1_RS19500	COG1984	allophanate hydrolase subunit 2
At12D1_RS19505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D1_RS19510	COG3842	ATPase activity
At12D1_RS19520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D1_RS19530	COG0436	Aminotransferase
At12D1_RS19545	COG0840	transmembrane signaling receptor activity
At12D1_RS19545	COG2972	Histidine kinase
At12D1_RS19550	COG1070	Carbohydrate kinase
At12D1_RS19555	COG1830	Aldolase
At12D1_RS19560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
At12D1_RS19565	COG0667	Aldo Keto reductase
At12D1_RS19575	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS19580	COG1129	ABC transporter
At12D1_RS19585	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS19620	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D1_RS19635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D1_RS19650	COG0395	ABC-type sugar transport system, permease component
At12D1_RS19665	COG3842	ATPase activity
At12D1_RS19680	COG1648	precorrin-2 dehydrogenase activity
At12D1_RS19680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D1_RS19685	COG0243	molybdopterin cofactor binding
At12D1_RS19700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
At12D1_RS19705	COG1116	anion transmembrane transporter activity
At12D1_RS19710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS19715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS19725	COG3707	response regulator
At12D1_RS19730	COG1802	Transcriptional regulator
At12D1_RS19735	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D1_RS19740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D1_RS19745	COG4336	lyase activity
At12D1_RS19750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
At12D1_RS19755	COG4770	biotin carboxylase activity
At12D1_RS19760	COG0366	Alpha amylase catalytic
At12D1_RS19770	COG4771	TonB-dependent receptor
At12D1_RS19775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D1_RS19795	COG1414	Transcriptional regulator
At12D1_RS19800	COG1475	DNA binding
At12D1_RS19805	COG1192	Involved in chromosome partitioning
At12D1_RS19835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
At12D1_RS19845	COG2986	histidine ammonia-lyase
At12D1_RS19850	COG1228	amidohydrolase
At12D1_RS19855	COG0402	S-adenosylhomocysteine deaminase activity
At12D1_RS19910	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS19915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS19920	COG0601	transmembrane transport
At12D1_RS19925	COG4166	transmembrane transport
At12D1_RS19930	COG0395	ABC-type sugar transport system, permease component
At12D1_RS19950	COG1566	PFAM secretion protein HlyD family protein
At12D1_RS19965	COG2207	Transcriptional regulator
At12D1_RS19970	COG1309	transcriptional regulator
At12D1_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS20000	COG1846	Transcriptional regulator
At12D1_RS20005	COG0583	DNA-binding transcription factor activity
At12D1_RS20010	COG2828	Protein conserved in bacteria
At12D1_RS20025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS20040	COG0840	transmembrane signaling receptor activity
At12D1_RS20060	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS20090	COG0583	DNA-binding transcription factor activity
At12D1_RS20095	COG0346	lactoylglutathione lyase activity
At12D1_RS20110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
At12D1_RS20130	COG0583	DNA-binding transcription factor activity
At12D1_RS20135	COG0477	Major facilitator Superfamily
At12D1_RS20145	COG2205	protein histidine kinase activity
At12D1_RS20150	COG0745	RESPONSE REGULATOR receiver
At12D1_RS20155	COG0671	phosphoesterase, PA-phosphatase related
At12D1_RS20210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
At12D1_RS20215	COG0156	8-amino-7-oxononanoate synthase activity
At12D1_RS20220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
At12D1_RS20225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D1_RS20230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D1_RS20245	COG2963	transposase activity
At12D1_RS20250	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS20255	COG2433	Pfam Transposase IS66
At12D1_RS20270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
At12D1_RS20270	COG1199	ATP-dependent helicase activity
At12D1_RS20300	COG0010	Belongs to the arginase family
At12D1_RS20310	COG0697	spore germination
At12D1_RS20315	COG0673	inositol 2-dehydrogenase activity
At12D1_RS20340	COG0477	Major facilitator Superfamily
At12D1_RS20355	COG2194	sulfuric ester hydrolase activity
At12D1_RS20365	COG0583	DNA-binding transcription factor activity
At12D1_RS20370	COG4774	siderophore transport
At12D1_RS20385	COG1120	ATPase activity
At12D1_RS20395	COG3474	cytochrome
At12D1_RS20400	COG2137	regulation of response to DNA damage stimulus
At12D1_RS20405	COG3386	PFAM SMP-30 Gluconolaconase
At12D1_RS20415	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS20420	COG1129	ABC transporter
At12D1_RS20425	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS20435	COG4585	Histidine kinase
At12D1_RS20440	COG2197	response regulator
At12D1_RS20450	COG2133	pyrroloquinoline quinone binding
At12D1_RS20460	COG0500	methyltransferase
At12D1_RS20465	COG0564	pseudouridine synthase activity
At12D1_RS20480	COG3448	diguanylate cyclase activity
At12D1_RS20480	COG4175	Glycine betaine
At12D1_RS20485	COG4176	ABC-type proline glycine betaine transport system permease component
At12D1_RS20495	COG0784	Response regulator, receiver
At12D1_RS20495	COG4191	Histidine kinase
At12D1_RS20500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D1_RS20505	COG0489	protein tyrosine kinase activity
At12D1_RS20505	COG3206	protein involved in exopolysaccharide biosynthesis
At12D1_RS20510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D1_RS20515	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS20520	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS20525	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS20530	COG0438	transferase activity, transferring glycosyl groups
At12D1_RS20535	COG2273	Hydrolase Family 16
At12D1_RS20540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D1_RS20545	COG2244	polysaccharide biosynthetic process
At12D1_RS20550	COG0463	Glycosyl transferase, family 2
At12D1_RS20555	COG2327	Polysaccharide pyruvyl transferase
At12D1_RS20560	COG1215	transferase activity, transferring glycosyl groups
At12D1_RS20580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D1_RS20590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS20605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D1_RS20605	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D1_RS20630	COG1523	belongs to the glycosyl hydrolase 13 family
At12D1_RS20635	COG0033	Phosphoglucomutase
At12D1_RS20640	COG0297	glycogen (starch) synthase activity
At12D1_RS20645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
At12D1_RS20650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D1_RS20655	COG0058	SHG alpha-glucan phosphorylase activity
At12D1_RS20670	COG1794	racemase activity, acting on amino acids and derivatives
At12D1_RS20675	COG1522	sequence-specific DNA binding
At12D1_RS20690	COG2084	Dehydrogenase
At12D1_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS20700	COG1063	alcohol dehydrogenase
At12D1_RS20710	COG4988	ABC transporter
At12D1_RS20715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
At12D1_RS20725	COG1294	oxidase, subunit
At12D1_RS20755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
At12D1_RS20760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
At12D1_RS20800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
At12D1_RS20805	COG0539	negative regulation of cytoplasmic translation
At12D1_RS20835	COG4221	oxidoreductase activity
At12D1_RS20850	COG0747	negative chemotaxis
At12D1_RS20855	COG0601	transmembrane transport
At12D1_RS20860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS20865	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS20870	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS20875	COG0246	Mannitol dehydrogenase
At12D1_RS20890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS20935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D1_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS20960	COG4993	Dehydrogenase
At12D1_RS20965	COG3685	Protein conserved in bacteria
At12D1_RS20995	COG0693	protein deglycase activity
At12D1_RS21020	COG0189	ligase activity
At12D1_RS21025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D1_RS21030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
At12D1_RS21040	COG0435	Glutathione S-transferase
At12D1_RS21045	COG0583	DNA-binding transcription factor activity
At12D1_RS21050	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS21055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS21060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS21065	COG1116	anion transmembrane transporter activity
At12D1_RS21080	COG1522	sequence-specific DNA binding
At12D1_RS21095	COG0784	Response regulator, receiver
At12D1_RS21105	COG3920	Histidine kinase
At12D1_RS21115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
At12D1_RS21130	COG0019	diaminopimelate decarboxylase activity
At12D1_RS21150	COG0527	aspartate kinase activity
At12D1_RS21160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
At12D1_RS21165	COG2890	protein-(glutamine-N5) methyltransferase activity
At12D1_RS21180	COG0542	response to heat
At12D1_RS21185	COG0741	lytic transglycosylase activity
At12D1_RS21185	COG1196	nuclear chromosome segregation
At12D1_RS21185	COG0739	heme binding
At12D1_RS21260	COG0776	regulation of translation
At12D1_RS21270	COG5489	Protein of unknown function (DUF736)
At12D1_RS21285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
At12D1_RS21300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
At12D1_RS21320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
At12D1_RS21325	COG0006	proline dipeptidase activity
At12D1_RS21335	COG1476	TRANSCRIPTIONal
At12D1_RS21385	COG0739	heme binding
At12D1_RS21385	COG0741	lytic transglycosylase activity
At12D1_RS21385	COG1196	nuclear chromosome segregation
At12D1_RS21425	COG4962	Type ii secretion system protein e
At12D1_RS21430	COG3838	Conjugal transfer protein Trbc
At12D1_RS21440	COG3451	type IV secretory pathway VirB4
At12D1_RS21470	COG2948	multi-organism process
At12D1_RS21490	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS21495	COG2963	transposase activity
At12D1_RS21505	COG3300	MHYT domain
At12D1_RS21505	COG5001	Diguanylate cyclase
At12D1_RS21525	COG3920	Histidine kinase
At12D1_RS21545	COG1484	DNA-dependent DNA replication
At12D1_RS21560	COG3620	sequence-specific DNA binding
At12D1_RS21565	COG3550	peptidyl-serine autophosphorylation
At12D1_RS21585	COG0840	transmembrane signaling receptor activity
At12D1_RS21595	COG5001	Diguanylate cyclase
At12D1_RS21605	COG4584	PFAM Integrase catalytic
At12D1_RS21610	COG5001	Diguanylate cyclase
At12D1_RS21615	COG0745	RESPONSE REGULATOR receiver
At12D1_RS21620	COG5001	Diguanylate cyclase
At12D1_RS21625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
At12D1_RS21630	COG2771	luxR family
At12D1_RS21630	COG2200	EAL domain
At12D1_RS21650	COG3422	double-strand break repair
At12D1_RS21655	COG1376	ErfK ybiS ycfS ynhG family protein
At12D1_RS21715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
At12D1_RS21720	COG0459	protein refolding
At12D1_RS21735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
At12D1_RS21750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D1_RS21755	COG4191	Histidine kinase
At12D1_RS21755	COG0784	Response regulator, receiver
At12D1_RS21775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D1_RS21785	COG1280	lysine exporter protein (LysE YggA)
At12D1_RS21800	COG1309	transcriptional regulator
At12D1_RS21805	COG4221	oxidoreductase activity
At12D1_RS21810	COG1902	pentaerythritol trinitrate reductase activity
At12D1_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS21825	COG0604	alcohol dehydrogenase
At12D1_RS21840	COG1278	Cold shock
At12D1_RS21860	COG0753	catalase activity
At12D1_RS21885	COG3920	Histidine kinase
At12D1_RS21905	COG1129	ABC transporter
At12D1_RS21910	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS21915	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS21940	COG0667	Aldo Keto reductase
At12D1_RS21955	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS21960	COG1129	ABC transporter
At12D1_RS21965	COG4213	ABC transporter substrate-binding protein
At12D1_RS21985	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS21990	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS21995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS22000	COG0601	transmembrane transport
At12D1_RS22005	COG0747	negative chemotaxis
At12D1_RS22025	COG0765	amino acid transport
At12D1_RS22030	COG4597	amino acid ABC transporter
At12D1_RS22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS22055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D1_RS22075	COG0625	glutathione transferase activity
At12D1_RS22080	COG4221	oxidoreductase activity
At12D1_RS22130	COG0656	L-ascorbic acid biosynthetic process
At12D1_RS22135	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS22140	COG1609	Transcriptional regulator
At12D1_RS22145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS22150	COG1126	abc transporter atp-binding protein
At12D1_RS22180	COG2376	Dihydroxyacetone kinase
At12D1_RS22185	COG1522	sequence-specific DNA binding
At12D1_RS22205	COG0431	NADPH-dependent FMN reductase
At12D1_RS22215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS22225	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS22230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS22255	COG0277	FAD linked oxidase domain protein
At12D1_RS22275	COG0778	Nitroreductase
At12D1_RS22305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D1_RS22330	COG2318	DinB family
At12D1_RS22335	COG0583	DNA-binding transcription factor activity
At12D1_RS22350	COG1335	isochorismatase
At12D1_RS22375	COG3842	ATPase activity
At12D1_RS22380	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D1_RS22385	COG1177	transmembrane transport
At12D1_RS22390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
At12D1_RS22400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D1_RS22415	COG1120	ATPase activity
At12D1_RS22420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS22425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS22430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
At12D1_RS22435	COG4774	siderophore transport
At12D1_RS22435	COG1629	transport
At12D1_RS22440	COG4702	Belongs to the UPF0303 family
At12D1_RS22460	COG1024	Enoyl-CoA hydratase
At12D1_RS22465	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS22470	COG1653	transport
At12D1_RS22475	COG1175	transmembrane transport
At12D1_RS22480	COG0395	ABC-type sugar transport system, permease component
At12D1_RS22485	COG3842	ATPase activity
At12D1_RS22510	COG3474	cytochrome
At12D1_RS22515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D1_RS22520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D1_RS22525	COG1845	cytochrome c oxidase, subunit III
At12D1_RS22550	COG0577	efflux transmembrane transporter activity
At12D1_RS22550	COG1136	(ABC) transporter
At12D1_RS22605	COG3842	ATPase activity
At12D1_RS22615	COG1177	transmembrane transport
At12D1_RS22620	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D1_RS22635	COG1940	carbohydrate kinase activity
At12D1_RS22655	COG1069	ribulokinase activity
At12D1_RS22660	COG1349	DNA-binding transcription factor activity
At12D1_RS22665	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS22690	COG0395	ABC-type sugar transport system, permease component
At12D1_RS22700	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS22715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D1_RS22725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
At12D1_RS22735	COG0477	Major facilitator Superfamily
At12D1_RS22745	COG0405	Gamma-glutamyltransferase
At12D1_RS22775	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
At12D1_RS22790	COG1733	regulation of RNA biosynthetic process
At12D1_RS22835	COG3938	Belongs to the proline racemase family
At12D1_RS22840	COG4176	ABC-type proline glycine betaine transport system permease component
At12D1_RS22850	COG3448	diguanylate cyclase activity
At12D1_RS22850	COG4175	Glycine betaine
At12D1_RS22860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS22865	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS22870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS22880	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D1_RS22885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS22895	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D1_RS22895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D1_RS22905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D1_RS22920	COG1309	transcriptional regulator
At12D1_RS22935	COG1136	(ABC) transporter
At12D1_RS22950	COG1063	alcohol dehydrogenase
At12D1_RS22960	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS22970	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS22990	COG0477	Major facilitator Superfamily
At12D1_RS23130	COG5001	Diguanylate cyclase
At12D1_RS23130	COG3300	MHYT domain
At12D1_RS23155	COG1253	flavin adenine dinucleotide binding
At12D1_RS23170	COG3842	ATPase activity
At12D1_RS23175	COG0395	ABC-type sugar transport system, permease component
At12D1_RS23180	COG1175	transmembrane transport
At12D1_RS23195	COG0673	inositol 2-dehydrogenase activity
At12D1_RS23200	COG1609	Transcriptional regulator
At12D1_RS23210	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS23215	COG0583	DNA-binding transcription factor activity
At12D1_RS23225	COG1879	ABC-type sugar transport system periplasmic component
At12D1_RS23230	COG1129	ABC transporter
At12D1_RS23235	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS23240	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS23245	COG1609	Transcriptional regulator
At12D1_RS23255	COG0673	inositol 2-dehydrogenase activity
At12D1_RS23315	COG0714	Associated with various cellular activities
At12D1_RS23320	COG3256	nitric oxide reductase
At12D1_RS23335	COG1845	cytochrome c oxidase, subunit III
At12D1_RS23350	COG0163	prenyltransferase activity
At12D1_RS23355	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
At12D1_RS23360	COG3189	MarR family transcriptional regulator
At12D1_RS23370	COG0826	peptidase U32
At12D1_RS23405	COG4459	periplasmic nitrate reductase
At12D1_RS23420	COG0243	molybdopterin cofactor binding
At12D1_RS23430	COG3005	denitrification pathway
At12D1_RS23445	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS23450	COG3433	isochorismatase activity
At12D1_RS23450	COG1535	isochorismatase
At12D1_RS23455	COG1021	2,3-dihydroxybenzoate-AMP ligase
At12D1_RS23460	COG1169	isochorismate synthase
At12D1_RS23470	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
At12D1_RS23470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
At12D1_RS23475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
At12D1_RS23485	COG2375	cellular response to nickel ion
At12D1_RS23495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS23500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS23510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS23520	COG4774	siderophore transport
At12D1_RS23520	COG1629	transport
At12D1_RS23525	COG1960	acyl-CoA dehydrogenase activity
At12D1_RS23530	COG0583	DNA-binding transcription factor activity
At12D1_RS23535	COG1609	Transcriptional regulator
At12D1_RS23545	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D1_RS23565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D1_RS23570	COG0583	DNA-binding transcription factor activity
At12D1_RS23575	COG2814	Major facilitator Superfamily
At12D1_RS23580	COG1473	amidohydrolase
At12D1_RS23585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
At12D1_RS23595	COG0747	negative chemotaxis
At12D1_RS23600	COG0601	transmembrane transport
At12D1_RS23605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS23610	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS23615	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS23620	COG0583	DNA-binding transcription factor activity
At12D1_RS23625	COG0747	negative chemotaxis
At12D1_RS23630	COG0601	transmembrane transport
At12D1_RS23635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS23640	COG0154	amidase activity
At12D1_RS23645	COG0693	protein deglycase activity
At12D1_RS23655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS23660	COG0601	transmembrane transport
At12D1_RS23670	COG1473	amidohydrolase
At12D1_RS23675	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS23680	COG2390	Transcriptional regulator
At12D1_RS23690	COG1175	transmembrane transport
At12D1_RS23695	COG0395	ABC-type sugar transport system, permease component
At12D1_RS23720	COG1069	ribulokinase activity
At12D1_RS23745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D1_RS23765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
At12D1_RS23770	COG1414	Transcriptional regulator
At12D1_RS23775	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS23785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D1_RS23790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D1_RS23795	COG1121	(ABC) transporter
At12D1_RS23800	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D1_RS23810	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D1_RS23815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
At12D1_RS23820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D1_RS23825	COG0471	metal ion transport
At12D1_RS23825	COG3273	potassium ion transport
At12D1_RS23830	COG2827	Endonuclease containing a URI domain
At12D1_RS23835	COG1253	flavin adenine dinucleotide binding
At12D1_RS23840	COG1309	transcriptional regulator
At12D1_RS23860	COG1609	Transcriptional regulator
At12D1_RS23865	COG1070	Carbohydrate kinase
At12D1_RS23870	COG2115	Belongs to the xylose isomerase family
At12D1_RS23885	COG0778	Nitroreductase
At12D1_RS23890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
At12D1_RS23895	COG2011	ABC-type metal ion transport system permease component
At12D1_RS23905	COG5001	Diguanylate cyclase
At12D1_RS23905	COG3300	MHYT domain
At12D1_RS23910	COG1054	Belongs to the UPF0176 family
At12D1_RS23920	COG2954	triphosphatase activity
At12D1_RS23925	COG0800	Aldolase
At12D1_RS23950	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
At12D1_RS23995	COG0523	cobalamin synthesis protein
At12D1_RS24005	COG1846	Transcriptional regulator
At12D1_RS24010	COG1609	Transcriptional regulator
At12D1_RS24015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D1_RS24030	COG3718	enzyme involved in inositol metabolism
At12D1_RS24040	COG3962	Belongs to the TPP enzyme family
At12D1_RS24045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS24060	COG0411	ABC transporter
At12D1_RS24075	COG0683	leucine binding
At12D1_RS24085	COG2207	Transcriptional regulator
At12D1_RS24095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS24105	COG0747	negative chemotaxis
At12D1_RS24135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D1_RS24140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D1_RS24145	COG1126	abc transporter atp-binding protein
At12D1_RS24150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS24155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS24160	COG0765	amino acid transport
At12D1_RS24165	COG0765	amino acid transport
At12D1_RS24170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
At12D1_RS24175	COG3485	protocatechuate 3,4-dioxygenase
At12D1_RS24180	COG3485	protocatechuate 3,4-dioxygenase
At12D1_RS24185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
At12D1_RS24190	COG2267	carboxylic ester hydrolase activity
At12D1_RS24195	COG0583	DNA-binding transcription factor activity
At12D1_RS24210	COG1414	Transcriptional regulator
At12D1_RS24220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
At12D1_RS24225	COG0183	Belongs to the thiolase family
At12D1_RS24235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D1_RS24240	COG1609	Transcriptional regulator
At12D1_RS24255	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS24260	COG0673	inositol 2-dehydrogenase activity
At12D1_RS24270	COG1609	Transcriptional regulator
At12D1_RS24275	COG0395	ABC-type sugar transport system, permease component
At12D1_RS24280	COG1175	transmembrane transport
At12D1_RS24285	COG3842	ATPase activity
At12D1_RS24295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D1_RS24315	COG2814	Major facilitator Superfamily
At12D1_RS24320	COG4774	siderophore transport
At12D1_RS24325	COG3712	iron ion homeostasis
At12D1_RS24335	COG1940	carbohydrate kinase activity
At12D1_RS24340	COG0584	glycerophosphoryl diester phosphodiesterase
At12D1_RS24345	COG0300	oxidoreductase activity
At12D1_RS24360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
At12D1_RS24385	COG3210	domain, Protein
At12D1_RS24385	COG3210	domain, Protein
At12D1_RS24415	COG2963	transposase activity
At12D1_RS24420	COG3436	PFAM IS66 Orf2 family protein
At12D1_RS24425	COG2433	Pfam Transposase IS66
At12D1_RS24460	COG0385	Bile acid
At12D1_RS24465	COG0667	Aldo Keto reductase
At12D1_RS24470	COG0583	DNA-binding transcription factor activity
At12D1_RS24480	COG2942	2-epimerase
At12D1_RS24485	COG1132	(ABC) transporter
At12D1_RS24495	COG0297	glycogen (starch) synthase activity
At12D1_RS24530	COG0463	Glycosyl transferase, family 2
At12D1_RS24540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D1_RS24550	COG0572	uridine kinase
At12D1_RS24575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS24580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS24585	COG1120	ATPase activity
At12D1_RS24590	COG4774	siderophore transport
At12D1_RS24605	COG1609	Transcriptional regulator
At12D1_RS24610	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D1_RS24610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D1_RS24625	COG0395	ABC-type sugar transport system, permease component
At12D1_RS24630	COG3842	ATPase activity
At12D1_RS24635	COG4608	Belongs to the ABC transporter superfamily
At12D1_RS24640	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS24645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS24650	COG0601	transmembrane transport
At12D1_RS24655	COG2186	Transcriptional regulator
At12D1_RS24675	COG5001	Diguanylate cyclase
At12D1_RS24675	COG3300	MHYT domain
At12D1_RS24680	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS24690	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D1_RS24700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D1_RS24705	COG0306	phosphate transporter
At12D1_RS24710	COG1392	Phosphate transport regulator
At12D1_RS24725	COG1566	PFAM secretion protein HlyD family protein
At12D1_RS24730	COG0745	RESPONSE REGULATOR receiver
At12D1_RS24735	COG2205	protein histidine kinase activity
At12D1_RS24750	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
At12D1_RS24765	COG4774	siderophore transport
At12D1_RS24775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS24780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D1_RS24785	COG1120	ATPase activity
At12D1_RS24830	COG1012	belongs to the aldehyde dehydrogenase family
At12D1_RS24835	COG0583	DNA-binding transcription factor activity
At12D1_RS24845	COG3119	arylsulfatase activity
At12D1_RS24850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D1_RS24855	COG3842	ATPase activity
At12D1_RS24860	COG0165	Argininosuccinate lyase
At12D1_RS24865	COG0395	ABC-type sugar transport system, permease component
At12D1_RS24870	COG1175	transmembrane transport
At12D1_RS24875	COG2182	Extracellular solute-binding protein
At12D1_RS24880	COG1940	carbohydrate kinase activity
At12D1_RS24905	COG1486	melibiose metabolic process
At12D1_RS24910	COG0747	negative chemotaxis
At12D1_RS24915	COG0601	transmembrane transport
At12D1_RS24920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS24925	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS24930	COG1486	melibiose metabolic process
At12D1_RS24935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D1_RS24940	COG0842	Transport permease protein
At12D1_RS24940	COG1129	ABC transporter
At12D1_RS24945	COG0842	Transport permease protein
At12D1_RS24965	COG0784	Response regulator, receiver
At12D1_RS24975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D1_RS24985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS24990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D1_RS25010	COG0765	amino acid transport
At12D1_RS25020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D1_RS25030	COG3938	Belongs to the proline racemase family
At12D1_RS25050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D1_RS25055	COG0765	amino acid transport
At12D1_RS25060	COG0765	amino acid transport
At12D1_RS25070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D1_RS25085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D1_RS25105	COG3383	formate dehydrogenase (NAD+) activity
At12D1_RS25115	COG2223	nitrite transmembrane transporter activity
At12D1_RS25120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D1_RS25130	COG2186	Transcriptional regulator
At12D1_RS25135	COG0747	negative chemotaxis
At12D1_RS25140	COG0601	transmembrane transport
At12D1_RS25145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS25150	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS25155	COG4948	Mandelate Racemase Muconate Lactonizing
At12D1_RS25165	COG2186	Transcriptional regulator
At12D1_RS25170	COG0747	negative chemotaxis
At12D1_RS25175	COG0601	transmembrane transport
At12D1_RS25180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS25185	COG0405	Gamma-glutamyltransferase
At12D1_RS25195	COG0483	inositol monophosphate 1-phosphatase activity
At12D1_RS25205	COG3842	ATPase activity
At12D1_RS25210	COG0395	ABC-type sugar transport system, permease component
At12D1_RS25230	COG3237	CsbD-like
At12D1_RS25240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D1_RS25245	COG3181	Tripartite tricarboxylate transporter family receptor
At12D1_RS25250	COG5265	(ABC) transporter
At12D1_RS25255	COG0488	(ABC) transporter
At12D1_RS25280	COG1049	propionate catabolic process, 2-methylcitrate cycle
At12D1_RS25285	COG0110	maltose O-acetyltransferase activity
At12D1_RS25295	COG1063	alcohol dehydrogenase
At12D1_RS25300	COG3284	Transcriptional regulator
At12D1_RS25320	COG1129	ABC transporter
At12D1_RS25325	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS25330	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS25340	COG0572	uridine kinase
At12D1_RS25345	COG1082	Xylose isomerase domain protein TIM barrel
At12D1_RS25370	COG4178	(ABC) transporter
At12D1_RS25405	COG0640	Transcriptional regulator
At12D1_RS25435	COG1192	Involved in chromosome partitioning
At12D1_RS25440	COG1475	DNA binding
At12D1_RS25445	COG0640	Transcriptional regulator
At12D1_RS25450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
At12D1_RS25500	COG0583	DNA-binding transcription factor activity
At12D1_RS25515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D1_RS25520	COG1116	anion transmembrane transporter activity
At12D1_RS25525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D1_RS25540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS25550	COG1028	Short-chain dehydrogenase reductase Sdr
At12D1_RS25580	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D1_RS25585	COG1129	ABC transporter
At12D1_RS25605	COG0747	negative chemotaxis
At12D1_RS25610	COG4172	Belongs to the ABC transporter superfamily
At12D1_RS25615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS25620	COG0601	transmembrane transport
At12D1_RS25635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS25640	COG0583	DNA-binding transcription factor activity
At12D1_RS25650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
At12D1_RS25780	COG1475	DNA binding
At12D1_RS25810	COG4974	Belongs to the 'phage' integrase family
At12D1_RS25815	COG4974	Belongs to the 'phage' integrase family
At12D1_RS25820	COG4974	Belongs to the 'phage' integrase family
At12D1_RS25830	COG0697	spore germination
At12D1_RS25850	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
At12D1_RS25855	COG5489	Protein of unknown function (DUF736)
At12D1_RS25910	COG0583	DNA-binding transcription factor activity
At12D1_RS25915	COG1126	abc transporter atp-binding protein
At12D1_RS25920	COG0765	amino acid transport
At12D1_RS25930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS25935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D1_RS25960	COG1283	sodium-dependent phosphate transmembrane transporter activity
At12D1_RS25975	COG0747	negative chemotaxis
At12D1_RS25995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS26000	COG0584	glycerophosphoryl diester phosphodiesterase
At12D1_RS26025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D1_RS26030	COG0601	transmembrane transport
At12D1_RS26045	COG0444	Belongs to the ABC transporter superfamily
At12D1_RS26050	COG0747	negative chemotaxis
At12D1_RS26060	COG2390	Transcriptional regulator
At12D1_RS26110	COG0145	ligase activity
At12D1_RS26120	COG0583	DNA-binding transcription factor activity
At12D1_RS26165	COG3701	Conjugal transfer protein
At12D1_RS26170	COG3846	protein secretion by the type IV secretion system
At12D1_RS26180	COG5314	conjugation
At12D1_RS26185	COG3451	type IV secretory pathway VirB4
At12D1_RS26200	COG4962	Type ii secretion system protein e