locus-tag	class	description
Ach5_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Ach5_RS00010	COG0424	maF-like protein
Ach5_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ach5_RS00020	COG0237	dephospho-CoA kinase activity
Ach5_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Ach5_RS00045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Ach5_RS00070	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ach5_RS00085	COG0135	phosphoribosylanthranilate isomerase activity
Ach5_RS00090	COG0133	tryptophan synthase activity
Ach5_RS00095	COG0159	tryptophan synthase activity
Ach5_RS00100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Ach5_RS00105	COG0285	dihydrofolate synthase activity
Ach5_RS00115	COG1074	ATP-dependent DNA helicase activity
Ach5_RS00125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ach5_RS00130	COG0802	atpase or kinase
Ach5_RS00135	COG2205	protein histidine kinase activity
Ach5_RS00145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Ach5_RS00150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ach5_RS00155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ach5_RS00155	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ach5_RS00160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Ach5_RS00165	COG0642	Histidine kinase
Ach5_RS00170	COG0745	RESPONSE REGULATOR receiver
Ach5_RS00175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Ach5_RS00185	COG1652	LysM domain
Ach5_RS00190	COG1072	(Pantothenic acid kinase))
Ach5_RS00195	COG0140	phosphoribosyl-ATP diphosphatase activity
Ach5_RS00200	COG0107	imidazoleglycerol-phosphate synthase activity
Ach5_RS00205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ach5_RS00210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ach5_RS00220	COG0131	Imidazoleglycerol-phosphate dehydratase
Ach5_RS00225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ach5_RS00230	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ach5_RS00240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Ach5_RS00255	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Ach5_RS00265	COG1643	Atp-dependent helicase
Ach5_RS00300	COG0514	ATP-dependent DNA helicase (RecQ)
Ach5_RS00325	COG1072	(Pantothenic acid kinase))
Ach5_RS00335	COG1780	Probably involved in ribonucleotide reductase function
Ach5_RS00355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ach5_RS00380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ach5_RS00395	COG1185	polyribonucleotide nucleotidyltransferase activity
Ach5_RS00400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Ach5_RS00405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Ach5_RS00410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ach5_RS00415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ach5_RS00415	COG3064	Membrane
Ach5_RS00430	COG0779	Required for maturation of 30S ribosomal subunits
Ach5_RS00435	COG2814	Major facilitator Superfamily
Ach5_RS00445	COG2951	lytic endotransglycosylase activity
Ach5_RS00450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ach5_RS00460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Ach5_RS00465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ach5_RS00475	COG2816	NAD+ diphosphatase activity
Ach5_RS00480	COG0077	Prephenate dehydratase
Ach5_RS00480	COG1605	Chorismate mutase
Ach5_RS00485	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ach5_RS00490	COG3474	cytochrome
Ach5_RS00500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ach5_RS00505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ach5_RS00515	COG1278	Cold shock
Ach5_RS00520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ach5_RS00530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ach5_RS00530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ach5_RS00540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Ach5_RS00570	COG2900	Belongs to the SlyX family
Ach5_RS00580	COG0484	heat shock protein binding
Ach5_RS00585	COG0443	Heat shock 70 kDa protein
Ach5_RS00600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ach5_RS00605	COG1744	ABC transporter substrate-binding protein PnrA-like
Ach5_RS00610	COG3845	ABC transporter
Ach5_RS00615	COG1079	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS00620	COG1079	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS00625	COG0295	cytidine deaminase activity
Ach5_RS00635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ach5_RS00640	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Ach5_RS00650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Ach5_RS00655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Ach5_RS00660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Ach5_RS00670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Ach5_RS00675	COG1845	cytochrome c oxidase, subunit III
Ach5_RS00680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ach5_RS00685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ach5_RS00690	COG0477	Major facilitator Superfamily
Ach5_RS00700	COG0067	glutamate synthase
Ach5_RS00700	COG0070	glutamate synthase
Ach5_RS00700	COG0069	glutamate synthase activity
Ach5_RS00705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Ach5_RS00720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ach5_RS00730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ach5_RS00765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ach5_RS00785	COG0848	biopolymer transport protein
Ach5_RS00795	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Ach5_RS00810	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Ach5_RS00815	COG3454	Phosphonate metabolism
Ach5_RS00820	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Ach5_RS00825	COG3639	organic phosphonate transmembrane transporter activity
Ach5_RS00830	COG3639	organic phosphonate transmembrane transporter activity
Ach5_RS00840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Ach5_RS00850	COG4778	phosphonate C-P lyase system protein PhnL
Ach5_RS00855	COG4107	phosphonate C-P lyase system protein PhnK
Ach5_RS00860	COG3627	carbon phosphorus lyase activity
Ach5_RS00865	COG3626	phosphonate metabolism
Ach5_RS00870	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Ach5_RS00875	COG3624	Phosphonate C-P lyase system protein PhnG
Ach5_RS00880	COG2188	Transcriptional regulator
Ach5_RS00885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Ach5_RS00890	COG0837	glucose binding
Ach5_RS00895	COG1803	Methylglyoxal synthase
Ach5_RS00900	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Ach5_RS00905	COG4166	transmembrane transport
Ach5_RS00910	COG4174	ABC transporter (Permease)
Ach5_RS00915	COG4239	(ABC) transporter, permease
Ach5_RS00920	COG4172	Belongs to the ABC transporter superfamily
Ach5_RS00925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ach5_RS00930	COG0174	glutamine synthetase
Ach5_RS00935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ach5_RS00940	COG3265	gluconokinase activity
Ach5_RS00945	COG1174	glycine betaine transport
Ach5_RS00950	COG1125	glycine betaine transport
Ach5_RS00955	COG1174	glycine betaine transport
Ach5_RS00960	COG1732	Glycine betaine
Ach5_RS00970	COG1959	2 iron, 2 sulfur cluster binding
Ach5_RS00975	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS00995	COG0697	spore germination
Ach5_RS01010	COG0791	NLP P60 protein
Ach5_RS01020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Ach5_RS01025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ach5_RS01060	COG4964	Belongs to the GSP D family
Ach5_RS01110	COG3422	double-strand break repair
Ach5_RS01115	COG3757	hydrolase, family 25
Ach5_RS01120	COG0697	spore germination
Ach5_RS01125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ach5_RS01155	COG0481	GTPase activity
Ach5_RS01160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ach5_RS01190	COG2169	Transcriptional regulator
Ach5_RS01190	COG1917	Cupin 2, conserved barrel domain protein
Ach5_RS01195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Ach5_RS01220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ach5_RS01225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ach5_RS01230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Ach5_RS01240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ach5_RS01245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ach5_RS01245	COG0072	phenylalanine-tRNA ligase activity
Ach5_RS01250	COG0667	Aldo Keto reductase
Ach5_RS01270	COG4977	sequence-specific DNA binding
Ach5_RS01295	COG1570	exodeoxyribonuclease VII activity
Ach5_RS01300	COG4948	Mandelate Racemase Muconate Lactonizing
Ach5_RS01310	COG1846	Transcriptional regulator
Ach5_RS01315	COG0697	spore germination
Ach5_RS01320	COG2309	aminopeptidase activity
Ach5_RS01330	COG1393	Belongs to the ArsC family
Ach5_RS01340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ach5_RS01340	COG0519	Catalyzes the synthesis of GMP from XMP
Ach5_RS01355	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Ach5_RS01385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Ach5_RS01395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ach5_RS01405	COG1968	undecaprenyl-diphosphatase activity
Ach5_RS01420	COG0284	orotidine-5'-phosphate decarboxylase activity
Ach5_RS01430	COG3963	phosphatidate phosphatase activity
Ach5_RS01440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ach5_RS01445	COG0792	nuclease activity
Ach5_RS01460	COG1175	transmembrane transport
Ach5_RS01465	COG0395	ABC-type sugar transport system, permease component
Ach5_RS01470	COG3842	ATPase activity
Ach5_RS01480	COG0189	ligase activity
Ach5_RS01490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ach5_RS01495	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS01500	COG0756	dUTP diphosphatase activity
Ach5_RS01505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Ach5_RS01510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ach5_RS01525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ach5_RS01530	COG2226	methyltransferase
Ach5_RS01535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ach5_RS01540	COG1024	Enoyl-CoA hydratase
Ach5_RS01545	COG0268	Binds directly to 16S ribosomal RNA
Ach5_RS01550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Ach5_RS01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ach5_RS01560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ach5_RS01565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Ach5_RS01570	COG1420	regulation of RNA biosynthetic process
Ach5_RS01575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ach5_RS01580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ach5_RS01585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Ach5_RS01595	COG1137	ATPase activity
Ach5_RS01600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Ach5_RS01610	COG0616	signal peptide processing
Ach5_RS01615	COG0776	regulation of translation
Ach5_RS01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ach5_RS01635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Ach5_RS01650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ach5_RS01655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Ach5_RS01660	COG0728	peptidoglycan biosynthetic process
Ach5_RS01670	COG0180	Tryptophanyl-tRNA synthetase
Ach5_RS01680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Ach5_RS01685	COG1214	PFAM Peptidase M22, glycoprotease
Ach5_RS01690	COG0456	acetyltransferase
Ach5_RS01690	COG1214	PFAM Peptidase M22, glycoprotease
Ach5_RS01705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ach5_RS01710	COG1702	phosphate starvation-inducible protein PhoH
Ach5_RS01715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ach5_RS01725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Ach5_RS01730	COG1396	sequence-specific DNA binding
Ach5_RS01735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ach5_RS01740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ach5_RS01745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ach5_RS01755	COG0242	peptide deformylase activity
Ach5_RS01760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ach5_RS01765	COG0101	tRNA pseudouridine synthase activity
Ach5_RS01775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ach5_RS01780	COG2171	N-acyltransferase activity
Ach5_RS01790	COG0840	transmembrane signaling receptor activity
Ach5_RS01800	COG0071	Belongs to the small heat shock protein (HSP20) family
Ach5_RS01825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ach5_RS01835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Ach5_RS01840	COG0706	membrane insertase activity
Ach5_RS01845	COG0594	ribonuclease P activity
Ach5_RS01850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Ach5_RS01860	COG0840	transmembrane signaling receptor activity
Ach5_RS01880	COG2226	methyltransferase
Ach5_RS01885	COG3842	ATPase activity
Ach5_RS01890	COG1175	transmembrane transport
Ach5_RS01895	COG0395	ABC-type sugar transport system, permease component
Ach5_RS01910	COG0427	acetyl-CoA hydrolase
Ach5_RS01920	COG3938	Belongs to the proline racemase family
Ach5_RS01925	COG0418	dihydroorotase activity
Ach5_RS01930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ach5_RS01950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ach5_RS01955	COG0166	Belongs to the GPI family
Ach5_RS01960	COG0318	PFAM AMP-dependent synthetase and ligase
Ach5_RS01965	COG3842	ATPase activity
Ach5_RS01970	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS01975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Ach5_RS01980	COG4774	siderophore transport
Ach5_RS02020	COG2326	polyphosphate kinase activity
Ach5_RS02025	COG5002	protein histidine kinase activity
Ach5_RS02030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ach5_RS02035	COG0573	inorganic phosphate transmembrane transporter activity
Ach5_RS02045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Ach5_RS02050	COG0704	Plays a role in the regulation of phosphate uptake
Ach5_RS02055	COG0745	RESPONSE REGULATOR receiver
Ach5_RS02065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ach5_RS02070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ach5_RS02080	COG2967	ApaG domain
Ach5_RS02090	COG0717	Belongs to the dCTP deaminase family
Ach5_RS02100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Ach5_RS02150	COG0167	dihydroorotate dehydrogenase activity
Ach5_RS02165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ach5_RS02185	COG1959	2 iron, 2 sulfur cluster binding
Ach5_RS02190	COG1201	RNA secondary structure unwinding
Ach5_RS02220	COG1960	acyl-CoA dehydrogenase activity
Ach5_RS02225	COG0183	Belongs to the thiolase family
Ach5_RS02230	COG1024	Enoyl-CoA hydratase
Ach5_RS02230	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ach5_RS02250	COG1320	monovalent cation:proton antiporter activity
Ach5_RS02255	COG2212	antiporter activity
Ach5_RS02260	COG1863	multisubunit Na H antiporter MnhE subunit
Ach5_RS02265	COG0651	ATP synthesis coupled electron transport
Ach5_RS02270	COG1006	Multisubunit Na H antiporter MnhC subunit
Ach5_RS02275	COG2111	Na H antiporter
Ach5_RS02275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ach5_RS02285	COG0840	transmembrane signaling receptor activity
Ach5_RS02295	COG0745	RESPONSE REGULATOR receiver
Ach5_RS02300	COG2198	Histidine kinase
Ach5_RS02300	COG0643	Histidine kinase
Ach5_RS02305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Ach5_RS02310	COG2201	protein-glutamate methylesterase activity
Ach5_RS02315	COG0745	RESPONSE REGULATOR receiver
Ach5_RS02320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Ach5_RS02330	COG1766	The M ring may be actively involved in energy transduction
Ach5_RS02335	COG2771	luxR family
Ach5_RS02345	COG2972	Histidine kinase
Ach5_RS02345	COG0840	transmembrane signaling receptor activity
Ach5_RS02355	COG1970	mechanosensitive ion channel activity
Ach5_RS02360	COG0436	Aminotransferase
Ach5_RS02375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Ach5_RS02380	COG0424	maF-like protein
Ach5_RS02385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ach5_RS02395	COG5328	Belongs to the UPF0262 family
Ach5_RS02400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Ach5_RS02410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ach5_RS02425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Ach5_RS02440	COG1338	Plays a role in the flagellum-specific transport system
Ach5_RS02450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Ach5_RS02460	COG1706	bacterial-type flagellum-dependent cell motility
Ach5_RS02465	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Ach5_RS02470	COG4786	Flagellar basal body rod
Ach5_RS02475	COG1677	Flagellar hook-basal body complex protein FliE
Ach5_RS02480	COG1558	bacterial-type flagellum-dependent cell motility
Ach5_RS02485	COG1815	bacterial-type flagellum-dependent cell motility
Ach5_RS02495	COG1157	protein secretion by the type III secretion system
Ach5_RS02500	COG4786	Flagellar basal body rod
Ach5_RS02510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Ach5_RS02515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ach5_RS02520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ach5_RS02525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ach5_RS02530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Ach5_RS02550	COG1360	Flagellar Motor Protein
Ach5_RS02575	COG1749	Flagellar hook protein flgE
Ach5_RS02595	COG5443	negative regulation of bacterial-type flagellum assembly
Ach5_RS02600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Ach5_RS02610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Ach5_RS02650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ach5_RS02655	COG1609	Transcriptional regulator
Ach5_RS02660	COG1653	transport
Ach5_RS02665	COG1175	transmembrane transport
Ach5_RS02670	COG0395	ABC-type sugar transport system, permease component
Ach5_RS02675	COG0366	Alpha amylase catalytic
Ach5_RS02680	COG3842	ATPase activity
Ach5_RS02695	COG0129	dihydroxy-acid dehydratase activity
Ach5_RS02700	COG0363	glucosamine-6-phosphate deaminase activity
Ach5_RS02705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Ach5_RS02715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ach5_RS02725	COG2081	HI0933 family
Ach5_RS02745	COG2224	Isocitrate lyase
Ach5_RS02760	COG3842	ATPase activity
Ach5_RS02765	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ach5_RS02770	COG1177	transmembrane transport
Ach5_RS02780	COG2205	protein histidine kinase activity
Ach5_RS02790	COG0248	Ppx GppA phosphatase
Ach5_RS02795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Ach5_RS02800	COG0477	Major facilitator Superfamily
Ach5_RS02835	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ach5_RS02840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ach5_RS02850	COG0142	geranyltranstransferase activity
Ach5_RS02875	COG0752	glycyl-tRNA synthetase alpha subunit
Ach5_RS02880	COG1704	LemA family
Ach5_RS02885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ach5_RS02895	COG0751	glycine-tRNA ligase activity
Ach5_RS02910	COG1683	Conserved Protein
Ach5_RS02915	COG0840	transmembrane signaling receptor activity
Ach5_RS02925	COG0151	Belongs to the GarS family
Ach5_RS02930	COG2183	response to ionizing radiation
Ach5_RS02935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ach5_RS02960	COG0583	DNA-binding transcription factor activity
Ach5_RS02980	COG0306	phosphate transporter
Ach5_RS02990	COG0561	phosphatase activity
Ach5_RS02995	COG0438	transferase activity, transferring glycosyl groups
Ach5_RS03000	COG2186	Transcriptional regulator
Ach5_RS03010	COG0583	DNA-binding transcription factor activity
Ach5_RS03015	COG0277	FAD linked oxidase domain protein
Ach5_RS03020	COG0277	FAD linked oxidase domain protein
Ach5_RS03025	COG0247	lactate metabolic process
Ach5_RS03035	COG1376	ErfK ybiS ycfS ynhG family protein
Ach5_RS03040	COG2818	Glycosylase
Ach5_RS03050	COG2855	membrane
Ach5_RS03055	COG0583	DNA-binding transcription factor activity
Ach5_RS03075	COG0124	histidyl-tRNA synthetase
Ach5_RS03085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Ach5_RS03090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ach5_RS03095	COG2259	Doxx family
Ach5_RS03105	COG0459	protein refolding
Ach5_RS03110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ach5_RS03120	COG0196	riboflavin kinase activity
Ach5_RS03125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ach5_RS03135	COG0590	tRNA wobble adenosine to inosine editing
Ach5_RS03140	COG1187	pseudouridine synthase activity
Ach5_RS03145	COG0742	ribosomal rna small subunit methyltransferase
Ach5_RS03150	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ach5_RS03160	COG0312	modulator of DNA gyrase
Ach5_RS03175	COG1519	Transferase
Ach5_RS03185	COG1663	tetraacyldisaccharide 4'-kinase activity
Ach5_RS03200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ach5_RS03205	COG2205	protein histidine kinase activity
Ach5_RS03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ach5_RS03210	COG5001	Diguanylate cyclase
Ach5_RS03210	COG3300	MHYT domain
Ach5_RS03215	COG3386	PFAM SMP-30 Gluconolaconase
Ach5_RS03220	COG0800	Aldolase
Ach5_RS03225	COG3734	2-keto-3-deoxy-galactonokinase
Ach5_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS03235	COG1414	Transcriptional regulator
Ach5_RS03240	COG2197	response regulator
Ach5_RS03255	COG0598	Magnesium transport protein CorA
Ach5_RS03260	COG3158	transport of potassium into the cell
Ach5_RS03275	COG0356	it plays a direct role in the translocation of protons across the membrane
Ach5_RS03285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ach5_RS03290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ach5_RS03300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ach5_RS03320	COG0009	L-threonylcarbamoyladenylate synthase
Ach5_RS03330	COG4638	Rieske (2fe-2S)
Ach5_RS03355	COG1960	acyl-CoA dehydrogenase activity
Ach5_RS03370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ach5_RS03375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Ach5_RS03380	COG0840	transmembrane signaling receptor activity
Ach5_RS03405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ach5_RS03410	COG1741	Belongs to the pirin family
Ach5_RS03415	COG1722	exodeoxyribonuclease VII activity
Ach5_RS03420	COG0123	including yeast histone deacetylase and acetoin utilization protein
Ach5_RS03425	COG1268	BioY protein
Ach5_RS03430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Ach5_RS03435	COG1122	ATPase activity
Ach5_RS03440	COG3214	Protein conserved in bacteria
Ach5_RS03445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ach5_RS03445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ach5_RS03450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ach5_RS03465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ach5_RS03470	COG0484	heat shock protein binding
Ach5_RS03480	COG0259	pyridoxamine-phosphate oxidase activity
Ach5_RS03495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ach5_RS03505	COG0312	modulator of DNA gyrase
Ach5_RS03525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ach5_RS03530	COG0109	protoheme IX farnesyltransferase activity
Ach5_RS03540	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Ach5_RS03555	COG3346	SURF1 family
Ach5_RS03560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ach5_RS03565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Ach5_RS03570	COG0328	RNA-DNA hybrid ribonuclease activity
Ach5_RS03585	COG0678	peroxiredoxin activity
Ach5_RS03585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ach5_RS03595	COG1678	Uncharacterized ACR, COG1678
Ach5_RS03615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ach5_RS03620	COG0612	Peptidase, M16
Ach5_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ach5_RS03655	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Ach5_RS03675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ach5_RS03680	COG1196	nuclear chromosome segregation
Ach5_RS03685	COG2514	catechol 2,3-dioxygenase activity
Ach5_RS03690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ach5_RS03690	COG0574	Belongs to the PEP-utilizing enzyme family
Ach5_RS03700	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Ach5_RS03705	COG1823	symporter activity
Ach5_RS03730	COG0579	oxidoreductase
Ach5_RS03760	COG2895	sulfate adenylyltransferase (ATP) activity
Ach5_RS03765	COG0175	sulfate reduction
Ach5_RS03770	COG0175	sulfate reduction
Ach5_RS03775	COG1959	2 iron, 2 sulfur cluster binding
Ach5_RS03780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Ach5_RS03785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Ach5_RS03790	COG4208	sulfate ABC transporter
Ach5_RS03795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ach5_RS03805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Ach5_RS03815	COG1309	transcriptional regulator
Ach5_RS03820	COG1012	belongs to the aldehyde dehydrogenase family
Ach5_RS03825	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Ach5_RS03865	COG1846	Transcriptional regulator
Ach5_RS03870	COG0477	Major facilitator Superfamily
Ach5_RS03880	COG1793	dna ligase
Ach5_RS03880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ach5_RS03895	COG1376	ErfK ybiS ycfS ynhG family protein
Ach5_RS03900	COG1376	ErfK ybiS ycfS ynhG family protein
Ach5_RS03915	COG1846	Transcriptional regulator
Ach5_RS03920	COG1764	response to oxidative stress
Ach5_RS03935	COG0488	(ABC) transporter
Ach5_RS03970	COG0583	DNA-binding transcription factor activity
Ach5_RS03975	COG4221	oxidoreductase activity
Ach5_RS03985	COG0433	COG0433 Predicted ATPase
Ach5_RS04000	COG1733	regulation of RNA biosynthetic process
Ach5_RS04005	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Ach5_RS04015	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS04020	COG0656	L-ascorbic acid biosynthetic process
Ach5_RS04035	COG4106	trans-aconitate 2-methyltransferase activity
Ach5_RS04040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ach5_RS04045	COG0840	transmembrane signaling receptor activity
Ach5_RS04050	COG0583	DNA-binding transcription factor activity
Ach5_RS04065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ach5_RS04085	COG3909	cytochrome
Ach5_RS04090	COG2010	Cytochrome c
Ach5_RS04120	COG0789	Transcriptional regulator
Ach5_RS04135	COG1230	cation diffusion facilitator family transporter
Ach5_RS04150	COG4176	ABC-type proline glycine betaine transport system permease component
Ach5_RS04170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ach5_RS04180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ach5_RS04180	COG2169	Transcriptional regulator
Ach5_RS04190	COG2514	catechol 2,3-dioxygenase activity
Ach5_RS04205	COG1272	protein, Hemolysin III
Ach5_RS04215	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS04220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ach5_RS04225	COG2111	Na H antiporter
Ach5_RS04225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ach5_RS04230	COG2111	Na H antiporter
Ach5_RS04235	COG1006	Multisubunit Na H antiporter MnhC subunit
Ach5_RS04240	COG0651	ATP synthesis coupled electron transport
Ach5_RS04245	COG1863	multisubunit Na H antiporter MnhE subunit
Ach5_RS04250	COG2212	antiporter activity
Ach5_RS04255	COG1320	monovalent cation:proton antiporter activity
Ach5_RS04260	COG4957	zinc ion binding
Ach5_RS04275	COG2166	iron-sulfur cluster assembly
Ach5_RS04285	COG2205	protein histidine kinase activity
Ach5_RS04330	COG0583	DNA-binding transcription factor activity
Ach5_RS04340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ach5_RS04345	COG2983	Belongs to the UPF0260 family
Ach5_RS04390	COG1621	beta-fructofuranosidase activity
Ach5_RS04395	COG3920	Histidine kinase
Ach5_RS04395	COG2202	Pas domain
Ach5_RS04400	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Ach5_RS04450	COG4695	Portal protein
Ach5_RS04555	COG4235	cytochrome complex assembly
Ach5_RS04560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Ach5_RS04565	COG1138	Cytochrome C-type biogenesis protein
Ach5_RS04570	COG3088	subunit of a heme lyase
Ach5_RS04575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ach5_RS04580	COG0745	RESPONSE REGULATOR receiver
Ach5_RS04590	COG3011	Protein conserved in bacteria
Ach5_RS04600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Ach5_RS04605	COG2202	Pas domain
Ach5_RS04605	COG2205	protein histidine kinase activity
Ach5_RS04615	COG0308	aminopeptidase N
Ach5_RS04635	COG0443	Heat shock 70 kDa protein
Ach5_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS04670	COG0604	alcohol dehydrogenase
Ach5_RS04675	COG1733	regulation of RNA biosynthetic process
Ach5_RS04680	COG1968	undecaprenyl-diphosphatase activity
Ach5_RS04685	COG2239	Acts as a magnesium transporter
Ach5_RS04690	COG2814	Major facilitator Superfamily
Ach5_RS04710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ach5_RS04735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ach5_RS04775	COG0741	lytic transglycosylase activity
Ach5_RS04785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ach5_RS04790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ach5_RS04795	COG0840	transmembrane signaling receptor activity
Ach5_RS04805	COG1758	RNA polymerase activity
Ach5_RS04825	COG0736	holo-[acyl-carrier-protein] synthase activity
Ach5_RS04830	COG0681	Belongs to the peptidase S26 family
Ach5_RS04835	COG0571	ribonuclease III activity
Ach5_RS04840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ach5_RS04845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ach5_RS04850	COG0784	Response regulator, receiver
Ach5_RS04855	COG1381	Involved in DNA repair and RecF pathway recombination
Ach5_RS04865	COG2226	methyltransferase
Ach5_RS04875	COG1418	mRNA catabolic process
Ach5_RS04885	COG0346	lactoylglutathione lyase activity
Ach5_RS04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ach5_RS04905	COG3443	Belongs to the bacterial solute-binding protein 9 family
Ach5_RS04910	COG0668	transmembrane transport
Ach5_RS04920	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Ach5_RS04925	COG0354	folic acid binding
Ach5_RS04950	COG1742	UPF0060 membrane protein
Ach5_RS04965	COG1183	phosphatidylcholine synthase activity
Ach5_RS04970	COG0688	phosphatidylethanolamine metabolic process
Ach5_RS04975	COG5265	(ABC) transporter
Ach5_RS05020	COG2852	Protein conserved in bacteria
Ach5_RS05025	COG0215	cysteine-tRNA ligase activity
Ach5_RS05030	COG4221	oxidoreductase activity
Ach5_RS05035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ach5_RS05040	COG1286	toxin biosynthetic process
Ach5_RS05060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ach5_RS05070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Ach5_RS05080	COG0305	Participates in initiation and elongation during chromosome replication
Ach5_RS05100	COG0359	binds to the 23S rRNA
Ach5_RS05110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Ach5_RS05115	COG0360	Binds together with S18 to 16S ribosomal RNA
Ach5_RS05120	COG0667	Aldo Keto reductase
Ach5_RS05125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ach5_RS05135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ach5_RS05140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ach5_RS05145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Ach5_RS05150	COG1561	YicC-like family, N-terminal region
Ach5_RS05155	COG0194	GDP metabolic process
Ach5_RS05165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ach5_RS05170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ach5_RS05180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Ach5_RS05195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ach5_RS05215	COG5001	Diguanylate cyclase
Ach5_RS05215	COG2203	Gaf domain
Ach5_RS05215	COG4251	negative regulation of phosphorylation
Ach5_RS05215	COG3706	GGDEF domain
Ach5_RS05225	COG0488	(ABC) transporter
Ach5_RS05230	COG3706	GGDEF domain
Ach5_RS05240	COG0105	UTP biosynthetic process
Ach5_RS05260	COG0314	molybdopterin synthase activity
Ach5_RS05270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ach5_RS05275	COG0322	excinuclease ABC activity
Ach5_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS05290	COG0625	glutathione transferase activity
Ach5_RS05305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Ach5_RS05310	COG0243	molybdopterin cofactor binding
Ach5_RS05325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Ach5_RS05330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ach5_RS05335	COG0628	permease
Ach5_RS05345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Ach5_RS05350	COG0248	Ppx GppA phosphatase
Ach5_RS05355	COG0456	acetyltransferase
Ach5_RS05380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Ach5_RS05390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Ach5_RS05395	COG0477	Major facilitator Superfamily
Ach5_RS05400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ach5_RS05405	COG4452	Inner membrane protein CreD
Ach5_RS05410	COG0659	secondary active sulfate transmembrane transporter activity
Ach5_RS05420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ach5_RS05425	COG3654	unkown
Ach5_RS05430	COG2336	PFAM SpoVT AbrB
Ach5_RS05435	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Ach5_RS05445	COG0113	porphobilinogen synthase activity
Ach5_RS05465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ach5_RS05470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Ach5_RS05475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ach5_RS05475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ach5_RS05485	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS05490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Ach5_RS05495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ach5_RS05500	COG2814	Major facilitator Superfamily
Ach5_RS05505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Ach5_RS05525	COG0416	fatty acid biosynthetic process
Ach5_RS05530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ach5_RS05535	COG0776	regulation of translation
Ach5_RS05570	COG0601	transmembrane transport
Ach5_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ach5_RS05580	COG0444	Belongs to the ABC transporter superfamily
Ach5_RS05600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ach5_RS05605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ach5_RS05620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Ach5_RS05625	COG0583	DNA-binding transcription factor activity
Ach5_RS05635	COG0737	Belongs to the 5'-nucleotidase family
Ach5_RS05660	COG2897	thiosulfate sulfurtransferase activity
Ach5_RS05675	COG0415	Belongs to the DNA photolyase family
Ach5_RS05685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ach5_RS05715	COG3932	Exopolysaccharide synthesis, ExoD
Ach5_RS05720	COG1238	metal cluster binding
Ach5_RS05735	COG4139	cobalamin transport
Ach5_RS05740	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Ach5_RS05745	COG3794	PFAM blue (type 1) copper domain protein
Ach5_RS05750	COG1528	Iron-storage protein
Ach5_RS05815	COG1612	heme a metabolic process
Ach5_RS05825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ach5_RS05830	COG0010	Belongs to the arginase family
Ach5_RS05835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Ach5_RS05840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Ach5_RS05850	COG1832	CoA-binding protein
Ach5_RS05865	COG2124	cytochrome p450
Ach5_RS05870	COG2199	diguanylate cyclase activity
Ach5_RS05875	COG0740	serine-type endopeptidase activity
Ach5_RS05880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ach5_RS05885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ach5_RS05895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ach5_RS05920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ach5_RS05925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ach5_RS05930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ach5_RS05940	COG0649	NAD binding
Ach5_RS05950	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Ach5_RS05955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ach5_RS05965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Ach5_RS05970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ach5_RS05980	COG0713	ATP synthesis coupled electron transport
Ach5_RS05995	COG1007	ATP synthesis coupled electron transport
Ach5_RS06000	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Ach5_RS06000	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Ach5_RS06015	COG0442	prolyl-tRNA aminoacylation
Ach5_RS06025	COG1136	(ABC) transporter
Ach5_RS06040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ach5_RS06050	COG0784	Response regulator, receiver
Ach5_RS06060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Ach5_RS06065	COG0477	Major facilitator Superfamily
Ach5_RS06080	COG0557	exoribonuclease II activity
Ach5_RS06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ach5_RS06095	COG0758	DNA mediated transformation
Ach5_RS06100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ach5_RS06110	COG0540	Belongs to the ATCase OTCase family
Ach5_RS06115	COG1960	acyl-CoA dehydrogenase activity
Ach5_RS06120	COG0456	acetyltransferase
Ach5_RS06135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Ach5_RS06140	COG2824	Alkylphosphonate utilization operon protein PhnA
Ach5_RS06145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Ach5_RS06150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ach5_RS06155	COG0154	amidase activity
Ach5_RS06160	COG3811	Belongs to the UPF0386 family
Ach5_RS06175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ach5_RS06185	COG0456	acetyltransferase
Ach5_RS06200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Ach5_RS06210	COG0511	ligase activity, forming carbon-carbon bonds
Ach5_RS06215	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ach5_RS06225	COG0436	Aminotransferase
Ach5_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS06250	COG1530	ribonuclease E activity
Ach5_RS06265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ach5_RS06285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Ach5_RS06290	COG0384	phenazine biosynthesis protein PhzF
Ach5_RS06305	COG0633	Ferredoxin
Ach5_RS06320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ach5_RS06325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ach5_RS06335	COG3768	UPF0283 membrane protein
Ach5_RS06340	COG3106	COG3106 Predicted ATPase
Ach5_RS06370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ach5_RS06410	COG0537	adenosine 5'-monophosphoramidase activity
Ach5_RS06435	COG0052	Belongs to the universal ribosomal protein uS2 family
Ach5_RS06440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ach5_RS06445	COG0528	UMP kinase activity
Ach5_RS06450	COG0233	cytoplasmic translational termination
Ach5_RS06455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ach5_RS06465	COG0750	zinc metalloprotease
Ach5_RS06470	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ach5_RS06475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ach5_RS06480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ach5_RS06485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ach5_RS06490	COG3494	Protein of unknown function (DUF1009)
Ach5_RS06495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ach5_RS06500	COG0372	Belongs to the citrate synthase family
Ach5_RS06515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ach5_RS06525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Ach5_RS06530	COG0148	phosphopyruvate hydratase activity
Ach5_RS06540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Ach5_RS06545	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ach5_RS06545	COG0022	dehydrogenase e1 component
Ach5_RS06550	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ach5_RS06560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ach5_RS06570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ach5_RS06575	COG0697	spore germination
Ach5_RS06590	COG2867	negative regulation of translational initiation
Ach5_RS06600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ach5_RS06600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ach5_RS06610	COG3852	Histidine kinase
Ach5_RS06615	COG2204	response regulator
Ach5_RS06620	COG5000	phosphorelay sensor kinase activity
Ach5_RS06625	COG2204	response regulator
Ach5_RS06630	COG0569	domain protein
Ach5_RS06635	COG1923	regulation of RNA biosynthetic process
Ach5_RS06640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ach5_RS06645	COG3956	TIGRFAM MazG family protein
Ach5_RS06655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ach5_RS06655	COG1648	precorrin-2 dehydrogenase activity
Ach5_RS06695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ach5_RS06695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ach5_RS06700	COG0509	glycine decarboxylation via glycine cleavage system
Ach5_RS06705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ach5_RS06735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ach5_RS06740	COG0564	pseudouridine synthase activity
Ach5_RS06765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Ach5_RS06775	COG1671	Belongs to the UPF0178 family
Ach5_RS06785	COG0450	alkyl hydroperoxide reductase
Ach5_RS06790	COG0625	glutathione transferase activity
Ach5_RS06830	COG0583	DNA-binding transcription factor activity
Ach5_RS06835	COG2828	Protein conserved in bacteria
Ach5_RS06850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ach5_RS06855	COG0784	Response regulator, receiver
Ach5_RS06855	COG4191	Histidine kinase
Ach5_RS06860	COG0784	Response regulator, receiver
Ach5_RS06865	COG2202	Pas domain
Ach5_RS06865	COG3920	Histidine kinase
Ach5_RS06870	COG4191	Histidine kinase
Ach5_RS06870	COG0784	Response regulator, receiver
Ach5_RS06900	COG0673	inositol 2-dehydrogenase activity
Ach5_RS06910	COG1609	Transcriptional regulator
Ach5_RS06915	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS06920	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS06925	COG1129	ABC transporter
Ach5_RS06930	COG1879	ABC-type sugar transport system periplasmic component
Ach5_RS06935	COG0328	RNA-DNA hybrid ribonuclease activity
Ach5_RS06945	COG2226	methyltransferase
Ach5_RS06955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Ach5_RS06955	COG0321	lipoyl(octanoyl) transferase activity
Ach5_RS06960	COG0084	hydrolase, TatD family'
Ach5_RS06965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ach5_RS06975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ach5_RS07195	COG3750	Belongs to the UPF0335 family
Ach5_RS07255	COG1396	sequence-specific DNA binding
Ach5_RS07290	COG0326	Molecular chaperone. Has ATPase activity
Ach5_RS07310	COG0582	viral genome integration into host DNA
Ach5_RS07350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ach5_RS07355	COG2095	MarC family integral membrane protein
Ach5_RS07360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Ach5_RS07360	COG0517	IMP dehydrogenase activity
Ach5_RS07360	COG0617	tRNA 3'-terminal CCA addition
Ach5_RS07365	COG0629	single-stranded DNA binding
Ach5_RS07370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ach5_RS07380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ach5_RS07385	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ach5_RS07400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ach5_RS07405	COG1121	(ABC) transporter
Ach5_RS07425	COG0667	Aldo Keto reductase
Ach5_RS07435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Ach5_RS07510	COG2239	Acts as a magnesium transporter
Ach5_RS07515	COG0243	molybdopterin cofactor binding
Ach5_RS07525	COG0242	peptide deformylase activity
Ach5_RS07555	COG0321	lipoyl(octanoyl) transferase activity
Ach5_RS07560	COG1064	alcohol dehydrogenase
Ach5_RS07590	COG1862	Preprotein translocase
Ach5_RS07610	COG2124	cytochrome p450
Ach5_RS07625	COG0596	Alpha beta hydrolase
Ach5_RS07635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ach5_RS07640	COG0626	cystathionine gamma-synthase activity
Ach5_RS07645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ach5_RS07650	COG4597	amino acid ABC transporter
Ach5_RS07655	COG0765	amino acid transport
Ach5_RS07660	COG1126	abc transporter atp-binding protein
Ach5_RS07675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ach5_RS07690	COG0436	Aminotransferase
Ach5_RS07720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ach5_RS07735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ach5_RS07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ach5_RS07745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ach5_RS07760	COG3243	poly(R)-hydroxyalkanoic acid synthase
Ach5_RS07765	COG1489	DNA binding
Ach5_RS07770	COG0024	Methionine aminopeptidase
Ach5_RS07775	COG2003	Belongs to the UPF0758 family
Ach5_RS07790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Ach5_RS07805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Ach5_RS07810	COG0546	phosphoglycolate phosphatase activity
Ach5_RS07820	COG0114	fumarate hydratase activity
Ach5_RS07830	COG0504	CTP synthase activity
Ach5_RS07840	COG0149	triose-phosphate isomerase activity
Ach5_RS07850	COG0187	DNA topoisomerase II activity
Ach5_RS07855	COG0740	serine-type endopeptidase activity
Ach5_RS07865	COG0640	Transcriptional regulator
Ach5_RS07870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ach5_RS07875	COG0745	RESPONSE REGULATOR receiver
Ach5_RS07895	COG3264	Mechanosensitive ion channel
Ach5_RS07895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Ach5_RS07960	COG1127	ABC transporter
Ach5_RS07965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Ach5_RS07970	COG4948	Mandelate Racemase Muconate Lactonizing
Ach5_RS07980	COG0281	malic enzyme
Ach5_RS07980	COG0280	phosphate acetyltransferase
Ach5_RS07990	COG0778	Nitroreductase
Ach5_RS07995	COG0823	Involved in the tonB-independent uptake of proteins
Ach5_RS08015	COG1368	sulfuric ester hydrolase activity
Ach5_RS08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ach5_RS08060	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Ach5_RS08085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Ach5_RS08120	COG0512	Glutamine amidotransferase of anthranilate synthase
Ach5_RS08120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ach5_RS08125	COG0343	queuine tRNA-ribosyltransferase activity
Ach5_RS08130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ach5_RS08145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ach5_RS08165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ach5_RS08170	COG0134	indole-3-glycerol-phosphate synthase activity
Ach5_RS08175	COG0315	cyclic pyranopterin monophosphate synthase activity
Ach5_RS08180	COG0303	'Molybdopterin
Ach5_RS08185	COG3706	GGDEF domain
Ach5_RS08195	COG0475	glutathione-regulated potassium exporter activity
Ach5_RS08195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ach5_RS08205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ach5_RS08210	COG0697	spore germination
Ach5_RS08215	COG2814	Major facilitator Superfamily
Ach5_RS08220	COG0746	molybdenum cofactor guanylyltransferase activity
Ach5_RS08225	COG1763	Mo-molybdopterin cofactor biosynthetic process
Ach5_RS08230	COG0739	heme binding
Ach5_RS08235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ach5_RS08240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ach5_RS08245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ach5_RS08250	COG0805	protein transport
Ach5_RS08255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ach5_RS08260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ach5_RS08265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Ach5_RS08270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Ach5_RS08275	COG1472	Belongs to the glycosyl hydrolase 3 family
Ach5_RS08285	COG0018	arginyl-trna synthetase
Ach5_RS08290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ach5_RS08295	COG0316	Belongs to the HesB IscA family
Ach5_RS08320	COG0525	valine-tRNA ligase activity
Ach5_RS08330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ach5_RS08355	COG0655	NAD(P)H dehydrogenase (quinone) activity
Ach5_RS08360	COG1546	Belongs to the CinA family
Ach5_RS08360	COG1058	Belongs to the CinA family
Ach5_RS08365	COG0589	response to stress
Ach5_RS08370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Ach5_RS08375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Ach5_RS08400	COG1132	(ABC) transporter
Ach5_RS08405	COG0628	permease
Ach5_RS08440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ach5_RS08450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Ach5_RS08460	COG0302	gtp cyclohydrolase
Ach5_RS08465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ach5_RS08470	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ach5_RS08475	COG0517	IMP dehydrogenase activity
Ach5_RS08475	COG0516	GMP reductase activity
Ach5_RS08510	COG1760	l-serine dehydratase
Ach5_RS08545	COG0583	DNA-binding transcription factor activity
Ach5_RS08560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ach5_RS08560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ach5_RS08565	COG0347	Belongs to the P(II) protein family
Ach5_RS08570	COG0174	glutamine synthetase
Ach5_RS08600	COG0697	spore germination
Ach5_RS08610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ach5_RS08620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ach5_RS08650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ach5_RS08655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ach5_RS08660	COG2186	Transcriptional regulator
Ach5_RS08670	COG1079	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS08675	COG4603	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS08680	COG3845	ABC transporter
Ach5_RS08685	COG1183	phosphatidylcholine synthase activity
Ach5_RS08690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ach5_RS08695	COG0679	Auxin Efflux Carrier
Ach5_RS08700	COG0785	Cytochrome C biogenesis protein
Ach5_RS08730	COG0346	lactoylglutathione lyase activity
Ach5_RS08735	COG1278	Cold shock
Ach5_RS08790	COG0577	efflux transmembrane transporter activity
Ach5_RS08790	COG1136	(ABC) transporter
Ach5_RS08795	COG0577	efflux transmembrane transporter activity
Ach5_RS08795	COG1136	(ABC) transporter
Ach5_RS08810	COG2151	metal-sulfur cluster biosynthetic enzyme
Ach5_RS08815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ach5_RS08820	COG0719	Fe-S assembly protein
Ach5_RS08825	COG0396	ATPase activity
Ach5_RS08830	COG0719	Fe-S assembly protein
Ach5_RS08835	COG1104	cysteine desulfurase activity
Ach5_RS08840	COG2945	thiolester hydrolase activity
Ach5_RS08845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Ach5_RS08850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ach5_RS08860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ach5_RS08865	COG2833	Protein of unknown function (DUF455)
Ach5_RS08870	COG0739	heme binding
Ach5_RS08875	COG0513	Belongs to the DEAD box helicase family
Ach5_RS08900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ach5_RS08910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ach5_RS08915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ach5_RS08920	COG0047	phosphoribosylformylglycinamidine synthase activity
Ach5_RS08935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ach5_RS08945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ach5_RS08970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Ach5_RS08975	COG2814	Major facilitator Superfamily
Ach5_RS08980	COG0483	inositol monophosphate 1-phosphatase activity
Ach5_RS08985	COG0483	inositol monophosphate 1-phosphatase activity
Ach5_RS08990	COG0037	tRNA processing
Ach5_RS08995	COG2066	Belongs to the glutaminase family
Ach5_RS09000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ach5_RS09005	COG0861	Integral membrane protein TerC family
Ach5_RS09025	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS09035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Ach5_RS09040	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Ach5_RS09050	COG0538	isocitrate dehydrogenase activity
Ach5_RS09065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ach5_RS09070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Ach5_RS09075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ach5_RS09080	COG2313	pseudouridylate synthase activity
Ach5_RS09090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ach5_RS09095	COG4215	(ABC) transporter
Ach5_RS09105	COG5425	PFAM Usg family protein
Ach5_RS09115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ach5_RS09120	COG1522	sequence-specific DNA binding
Ach5_RS09125	COG1573	uracil-dna glycosylase
Ach5_RS09135	COG2202	Pas domain
Ach5_RS09135	COG2205	protein histidine kinase activity
Ach5_RS09145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Ach5_RS09150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Ach5_RS09165	COG0842	Transport permease protein
Ach5_RS09170	COG1131	(ABC) transporter
Ach5_RS09175	COG0730	response to heat
Ach5_RS09185	COG0840	transmembrane signaling receptor activity
Ach5_RS09185	COG0840	transmembrane signaling receptor activity
Ach5_RS09195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ach5_RS09200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ach5_RS09215	COG0129	dihydroxy-acid dehydratase activity
Ach5_RS09220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Ach5_RS09225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Ach5_RS09235	COG3739	integral membrane protein
Ach5_RS09245	COG0203	ribosomal protein L17
Ach5_RS09250	COG0202	RNA polymerase activity
Ach5_RS09255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ach5_RS09260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ach5_RS09265	COG0563	adenylate kinase activity
Ach5_RS09270	COG0201	protein transport
Ach5_RS09275	COG0200	Binds to the 23S rRNA
Ach5_RS09280	COG1841	ribosomal large subunit assembly
Ach5_RS09285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ach5_RS09290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ach5_RS09295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Ach5_RS09300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ach5_RS09305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Ach5_RS09310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ach5_RS09315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ach5_RS09320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Ach5_RS09325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ach5_RS09330	COG0255	Belongs to the universal ribosomal protein uL29 family
Ach5_RS09335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ach5_RS09340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Ach5_RS09345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ach5_RS09350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Ach5_RS09355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ach5_RS09360	COG0089	rRNA binding
Ach5_RS09365	COG0088	Forms part of the polypeptide exit tunnel
Ach5_RS09370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Ach5_RS09375	COG0051	transcription antitermination factor activity, RNA binding
Ach5_RS09380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ach5_RS09385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ach5_RS09390	COG0049	tRNA binding
Ach5_RS09395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Ach5_RS09410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ach5_RS09415	COG0085	RNA polymerase activity
Ach5_RS09420	COG0222	ribosome binding
Ach5_RS09425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Ach5_RS09430	COG0081	regulation of translation
Ach5_RS09435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ach5_RS09445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ach5_RS09460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ach5_RS09465	COG0861	Integral membrane protein TerC family
Ach5_RS09500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ach5_RS09505	COG1607	acyl-coa hydrolase
Ach5_RS09530	COG2910	NAD(P)H-binding
Ach5_RS09535	COG1733	regulation of RNA biosynthetic process
Ach5_RS09545	COG0556	nucleotide-excision repair
Ach5_RS09575	COG0484	heat shock protein binding
Ach5_RS09600	COG3842	ATPase activity
Ach5_RS09610	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS09615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ach5_RS09630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ach5_RS09640	COG2207	Transcriptional regulator
Ach5_RS09645	COG1064	alcohol dehydrogenase
Ach5_RS09650	COG1252	NADH dehydrogenase
Ach5_RS09655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Ach5_RS09660	COG2197	response regulator
Ach5_RS09665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ach5_RS09670	COG1090	epimerase
Ach5_RS09710	COG0656	L-ascorbic acid biosynthetic process
Ach5_RS09725	COG0440	acetolactate synthase activity
Ach5_RS09730	COG0028	Belongs to the TPP enzyme family
Ach5_RS09740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ach5_RS09745	COG0560	Phosphoserine phosphatase
Ach5_RS09745	COG3830	Belongs to the UPF0237 family
Ach5_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS09765	COG0330	HflC and HflK could
Ach5_RS09770	COG0330	HflC and HflK could
Ach5_RS09780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Ach5_RS09815	COG0277	FAD linked oxidase domain protein
Ach5_RS09825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ach5_RS09880	COG1335	isochorismatase
Ach5_RS09900	COG0006	proline dipeptidase activity
Ach5_RS09910	COG2264	protein methyltransferase activity
Ach5_RS09915	COG1999	signal sequence binding
Ach5_RS09925	COG0835	chemotaxis
Ach5_RS09935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ach5_RS09940	COG0583	DNA-binding transcription factor activity
Ach5_RS09950	COG1247	-acetyltransferase
Ach5_RS09960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ach5_RS09965	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS09975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ach5_RS09985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ach5_RS09990	COG0849	cell division
Ach5_RS09995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Ach5_RS10000	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ach5_RS10005	COG0477	Major facilitator Superfamily
Ach5_RS10015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ach5_RS10020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ach5_RS10025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ach5_RS10035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Ach5_RS10040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ach5_RS10050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ach5_RS10065	COG0275	rRNA processing
Ach5_RS10070	COG2001	Belongs to the MraZ family
Ach5_RS10080	COG3766	membrane
Ach5_RS10090	COG0754	glutathionylspermidine amidase activity
Ach5_RS10110	COG3023	N-Acetylmuramoyl-L-alanine amidase
Ach5_RS10140	COG4106	trans-aconitate 2-methyltransferase activity
Ach5_RS10160	COG2226	methyltransferase
Ach5_RS10170	COG2267	carboxylic ester hydrolase activity
Ach5_RS10175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Ach5_RS10190	COG0251	oxidation-reduction process
Ach5_RS10205	COG1376	ErfK ybiS ycfS ynhG family protein
Ach5_RS10210	COG2814	Major facilitator Superfamily
Ach5_RS10235	COG1012	belongs to the aldehyde dehydrogenase family
Ach5_RS10240	COG0174	glutamine synthetase
Ach5_RS10245	COG0531	amino acid
Ach5_RS10255	COG1737	Transcriptional regulator
Ach5_RS10275	COG3842	ATPase activity
Ach5_RS10335	COG2968	Membrane
Ach5_RS10345	COG0432	Pfam Uncharacterised protein family UPF0047
Ach5_RS10360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ach5_RS10365	COG0358	DNA primase activity
Ach5_RS10380	COG0505	Belongs to the CarA family
Ach5_RS10385	COG0534	Mate efflux family protein
Ach5_RS10400	COG2321	neutral zinc metallopeptidase
Ach5_RS10415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ach5_RS10420	COG3706	GGDEF domain
Ach5_RS10425	COG1573	uracil-dna glycosylase
Ach5_RS10435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ach5_RS10445	COG1522	sequence-specific DNA binding
Ach5_RS10450	COG0492	ferredoxin-NADP+ reductase activity
Ach5_RS10455	COG0583	DNA-binding transcription factor activity
Ach5_RS10465	COG1902	pentaerythritol trinitrate reductase activity
Ach5_RS10490	COG0387	Pfam Sodium calcium exchanger
Ach5_RS10495	COG0436	Aminotransferase
Ach5_RS10500	COG2199	diguanylate cyclase activity
Ach5_RS10500	COG2200	EAL domain
Ach5_RS10520	COG1278	Cold shock
Ach5_RS10525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ach5_RS10535	COG1846	Transcriptional regulator
Ach5_RS10540	COG0745	RESPONSE REGULATOR receiver
Ach5_RS10545	COG2205	protein histidine kinase activity
Ach5_RS10550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ach5_RS10570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Ach5_RS10580	COG1496	oxidoreductase activity
Ach5_RS10595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ach5_RS10605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ach5_RS10620	COG0840	transmembrane signaling receptor activity
Ach5_RS10625	COG1012	belongs to the aldehyde dehydrogenase family
Ach5_RS10635	COG5001	Diguanylate cyclase
Ach5_RS10635	COG3300	MHYT domain
Ach5_RS10640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ach5_RS10645	COG5001	Diguanylate cyclase
Ach5_RS10655	COG0193	aminoacyl-tRNA hydrolase activity
Ach5_RS10665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ach5_RS10685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ach5_RS10690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Ach5_RS10700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Ach5_RS10700	COG2857	Cytochrome c1
Ach5_RS10725	COG1132	(ABC) transporter
Ach5_RS10730	COG1132	(ABC) transporter
Ach5_RS10735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Ach5_RS10750	COG0408	coproporphyrinogen oxidase activity
Ach5_RS10765	COG0617	tRNA 3'-terminal CCA addition
Ach5_RS10780	COG0714	Associated with various cellular activities
Ach5_RS10800	COG0454	-acetyltransferase
Ach5_RS10805	COG0477	Major facilitator Superfamily
Ach5_RS10815	COG0435	Glutathione S-transferase
Ach5_RS10830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ach5_RS10835	COG3135	benzoate transporter
Ach5_RS10840	COG4944	Protein of unknown function (DUF1109)
Ach5_RS10855	COG0740	serine-type endopeptidase activity
Ach5_RS10870	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Ach5_RS10875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Ach5_RS10900	COG4175	Glycine betaine
Ach5_RS10915	COG1435	thymidine kinase activity
Ach5_RS10935	COG2862	Uncharacterized protein family, UPF0114
Ach5_RS10950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ach5_RS10950	COG0512	Glutamine amidotransferase of anthranilate synthase
Ach5_RS10960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Ach5_RS10975	COG0366	Alpha amylase catalytic
Ach5_RS10980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ach5_RS10995	COG1160	GTP binding
Ach5_RS11015	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Ach5_RS11025	COG0024	Methionine aminopeptidase
Ach5_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS11050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Ach5_RS11060	COG0583	DNA-binding transcription factor activity
Ach5_RS11075	COG0402	S-adenosylhomocysteine deaminase activity
Ach5_RS11100	COG1309	transcriptional regulator
Ach5_RS11105	COG1686	Belongs to the peptidase S11 family
Ach5_RS11115	COG2351	hydroxyisourate hydrolase activity
Ach5_RS11120	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Ach5_RS11145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Ach5_RS11155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ach5_RS11155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Ach5_RS11160	COG5002	protein histidine kinase activity
Ach5_RS11160	COG2205	protein histidine kinase activity
Ach5_RS11160	COG0784	Response regulator, receiver
Ach5_RS11165	COG0513	Belongs to the DEAD box helicase family
Ach5_RS11175	COG2259	Doxx family
Ach5_RS11180	COG1376	ErfK ybiS ycfS ynhG family protein
Ach5_RS11190	COG2308	Evidence 4 Homologs of previously reported genes of
Ach5_RS11200	COG1305	Transglutaminase-like
Ach5_RS11220	COG0588	phosphoglycerate mutase activity
Ach5_RS11230	COG4214	carbohydrate transport
Ach5_RS11240	COG4213	ABC transporter substrate-binding protein
Ach5_RS11280	COG0840	transmembrane signaling receptor activity
Ach5_RS11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ach5_RS11330	COG1215	transferase activity, transferring glycosyl groups
Ach5_RS11345	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ach5_RS11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ach5_RS11370	COG2346	COG2346, Truncated hemoglobins
Ach5_RS11390	COG1309	transcriptional regulator
Ach5_RS11405	COG0494	nUDIX hydrolase
Ach5_RS11420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ach5_RS11425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ach5_RS11455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ach5_RS11460	COG0830	nickel cation binding
Ach5_RS11465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Ach5_RS11480	COG0804	urea catabolic process
Ach5_RS11485	COG1442	glycosyl transferase family 8
Ach5_RS11490	COG3755	Protein conserved in bacteria
Ach5_RS11500	COG0832	Belongs to the urease beta subunit family
Ach5_RS11505	COG3813	Protein conserved in bacteria
Ach5_RS11510	COG0831	urea catabolic process
Ach5_RS11515	COG0829	nickel cation binding
Ach5_RS11540	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS11555	COG0174	glutamine synthetase
Ach5_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS11565	COG5002	protein histidine kinase activity
Ach5_RS11565	COG2198	Histidine kinase
Ach5_RS11565	COG0784	Response regulator, receiver
Ach5_RS11610	COG1218	3'(2'),5'-bisphosphate nucleotidase
Ach5_RS11685	COG0564	pseudouridine synthase activity
Ach5_RS11700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ach5_RS11710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Ach5_RS11735	COG0346	lactoylglutathione lyase activity
Ach5_RS11745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Ach5_RS11755	COG2832	Protein of unknown function (DUF454)
Ach5_RS11760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Ach5_RS11765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ach5_RS11770	COG4558	Periplasmic binding protein
Ach5_RS11780	COG3721	Heme iron utilization protein
Ach5_RS11800	COG2205	protein histidine kinase activity
Ach5_RS11840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ach5_RS11845	COG4605	iron ion homeostasis
Ach5_RS11850	COG4604	ABC transporter, ATP-binding protein
Ach5_RS11855	COG0783	Belongs to the Dps family
Ach5_RS11870	COG2972	Histidine kinase
Ach5_RS11870	COG0840	transmembrane signaling receptor activity
Ach5_RS11875	COG0656	L-ascorbic acid biosynthetic process
Ach5_RS11880	COG2814	Major facilitator Superfamily
Ach5_RS11890	COG0583	DNA-binding transcription factor activity
Ach5_RS11895	COG0657	acetylesterase activity
Ach5_RS11900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ach5_RS11920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ach5_RS11925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Ach5_RS11930	COG0288	reversible hydration of carbon dioxide
Ach5_RS11940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ach5_RS11960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Ach5_RS11965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ach5_RS11970	COG0778	Nitroreductase
Ach5_RS11975	COG2267	carboxylic ester hydrolase activity
Ach5_RS11980	COG0251	oxidation-reduction process
Ach5_RS11985	COG1335	isochorismatase
Ach5_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ach5_RS12000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ach5_RS12015	COG1175	transmembrane transport
Ach5_RS12020	COG0395	ABC-type sugar transport system, permease component
Ach5_RS12025	COG3842	ATPase activity
Ach5_RS12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ach5_RS12040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ach5_RS12055	COG4608	Belongs to the ABC transporter superfamily
Ach5_RS12060	COG0444	Belongs to the ABC transporter superfamily
Ach5_RS12065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ach5_RS12070	COG0601	transmembrane transport
Ach5_RS12090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Ach5_RS12090	COG0392	lysyltransferase activity
Ach5_RS12130	COG2159	amidohydrolase
Ach5_RS12135	COG1960	acyl-CoA dehydrogenase activity
Ach5_RS12160	COG0745	RESPONSE REGULATOR receiver
Ach5_RS12170	COG1902	pentaerythritol trinitrate reductase activity
Ach5_RS12170	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ach5_RS12175	COG3842	ATPase activity
Ach5_RS12185	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS12190	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS12195	COG0745	RESPONSE REGULATOR receiver
Ach5_RS12210	COG1192	Involved in chromosome partitioning
Ach5_RS12215	COG2201	protein-glutamate methylesterase activity
Ach5_RS12220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Ach5_RS12225	COG0835	chemotaxis
Ach5_RS12230	COG0840	transmembrane signaling receptor activity
Ach5_RS12235	COG0835	chemotaxis
Ach5_RS12240	COG2198	Histidine kinase
Ach5_RS12240	COG0643	Histidine kinase
Ach5_RS12305	COG0277	FAD linked oxidase domain protein
Ach5_RS12315	COG1017	nitric oxide dioxygenase activity
Ach5_RS12315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ach5_RS12350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ach5_RS12360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ach5_RS12365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ach5_RS12375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ach5_RS12400	COG0583	DNA-binding transcription factor activity
Ach5_RS12405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ach5_RS12410	COG0725	ABC transporter, periplasmic molybdate-binding protein
Ach5_RS12415	COG4149	molybdate abc transporter
Ach5_RS12420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Ach5_RS12435	COG2022	thiamine diphosphate biosynthetic process
Ach5_RS12450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Ach5_RS12455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ach5_RS12465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ach5_RS12485	COG1132	(ABC) transporter
Ach5_RS12490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ach5_RS12515	COG0438	transferase activity, transferring glycosyl groups
Ach5_RS12535	COG4166	transmembrane transport
Ach5_RS12540	COG0601	transmembrane transport
Ach5_RS12545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ach5_RS12560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ach5_RS12565	COG3142	Participates in the control of copper homeostasis
Ach5_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS12590	COG1737	Transcriptional regulator
Ach5_RS12600	COG3842	ATPase activity
Ach5_RS12610	COG0395	ABC-type sugar transport system, permease component
Ach5_RS12625	COG2188	Transcriptional regulator
Ach5_RS12630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ach5_RS12635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Ach5_RS12640	COG1940	carbohydrate kinase activity
Ach5_RS12650	COG0671	phosphoesterase, PA-phosphatase related
Ach5_RS12655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ach5_RS12660	COG0156	8-amino-7-oxononanoate synthase activity
Ach5_RS12670	COG0729	surface antigen
Ach5_RS12680	COG0835	chemotaxis
Ach5_RS12690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Ach5_RS12695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Ach5_RS12700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Ach5_RS12705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Ach5_RS12710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Ach5_RS12715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ach5_RS12730	COG4974	Belongs to the 'phage' integrase family
Ach5_RS12755	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS12765	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ach5_RS12770	COG0567	Dehydrogenase, E1 component
Ach5_RS12775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ach5_RS12780	COG0045	succinate-CoA ligase (ADP-forming) activity
Ach5_RS12785	COG0039	L-malate dehydrogenase activity
Ach5_RS12790	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Ach5_RS12825	COG2264	protein methyltransferase activity
Ach5_RS12840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ach5_RS12845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ach5_RS12850	COG0181	hydroxymethylbilane synthase activity
Ach5_RS12890	COG1872	DUF167
Ach5_RS12895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ach5_RS12905	COG1217	gtp-binding protein TYPA
Ach5_RS12910	COG0339	signal peptide processing
Ach5_RS12920	COG1846	Transcriptional regulator
Ach5_RS12930	COG0137	argininosuccinate synthase activity
Ach5_RS12940	COG1280	lysine exporter protein (LysE YggA)
Ach5_RS12945	COG1122	ATPase activity
Ach5_RS12950	COG4120	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS12960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ach5_RS12975	COG2154	pterin-4-alpha-carbinolamine dehydratase
Ach5_RS12980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ach5_RS12985	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Ach5_RS12995	COG4181	ATPase activity
Ach5_RS13005	COG0670	Belongs to the BI1 family
Ach5_RS13020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Ach5_RS13025	COG4133	protoheme IX ABC transporter activity
Ach5_RS13030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ach5_RS13035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ach5_RS13060	COG2917	probably involved in intracellular septation
Ach5_RS13065	COG0552	protein localization to endoplasmic reticulum
Ach5_RS13070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ach5_RS13075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ach5_RS13085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ach5_RS13090	COG1605	Chorismate mutase
Ach5_RS13090	COG0287	Prephenate dehydrogenase
Ach5_RS13095	COG0228	four-way junction DNA binding
Ach5_RS13100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ach5_RS13105	COG0336	Belongs to the RNA methyltransferase TrmD family
Ach5_RS13115	COG0335	large ribosomal subunit rRNA binding
Ach5_RS13120	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
Ach5_RS13125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ach5_RS13145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ach5_RS13160	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Ach5_RS13180	COG0488	(ABC) transporter
Ach5_RS13190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Ach5_RS13200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Ach5_RS13205	COG0142	geranyltranstransferase activity
Ach5_RS13210	COG2885	chlorophyll binding
Ach5_RS13215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ach5_RS13220	COG2223	nitrite transmembrane transporter activity
Ach5_RS13225	COG1349	DNA-binding transcription factor activity
Ach5_RS13230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Ach5_RS13240	COG1132	(ABC) transporter
Ach5_RS13250	COG3459	Glycosyltransferase 36 associated
Ach5_RS13255	COG1473	amidohydrolase
Ach5_RS13265	COG0579	oxidoreductase
Ach5_RS13275	COG0129	dihydroxy-acid dehydratase activity
Ach5_RS13280	COG2084	Dehydrogenase
Ach5_RS13285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ach5_RS13290	COG0277	FAD linked oxidase domain protein
Ach5_RS13295	COG2186	Transcriptional regulator
Ach5_RS13305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Ach5_RS13310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Ach5_RS13315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Ach5_RS13320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ach5_RS13335	COG0495	leucyl-tRNA aminoacylation
Ach5_RS13350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ach5_RS13355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ach5_RS13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ach5_RS13370	COG1946	Acyl-CoA thioesterase
Ach5_RS13375	COG0347	Belongs to the P(II) protein family
Ach5_RS13380	COG0004	ammonium transporteR
Ach5_RS13385	COG1674	ftsk spoiiie
Ach5_RS13390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Ach5_RS13405	COG0745	RESPONSE REGULATOR receiver
Ach5_RS13415	COG1329	Transcriptional regulator
Ach5_RS13420	COG2902	Dehydrogenase
Ach5_RS13425	COG2270	Major facilitator Superfamily
Ach5_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
Ach5_RS13455	COG0494	nUDIX hydrolase
Ach5_RS13465	COG0793	Belongs to the peptidase S41A family
Ach5_RS13475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Ach5_RS13480	COG0799	negative regulation of ribosome biogenesis
Ach5_RS13485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ach5_RS13490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ach5_RS13495	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ach5_RS13500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ach5_RS13515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ach5_RS13520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ach5_RS13545	COG0066	3-isopropylmalate dehydratase activity
Ach5_RS13550	COG0473	3-isopropylmalate dehydrogenase activity
Ach5_RS13555	COG1858	cytochrome C peroxidase
Ach5_RS13560	COG1797	cobyrinic acid a,c-diamide synthase activity
Ach5_RS13565	COG1648	precorrin-2 dehydrogenase activity
Ach5_RS13565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ach5_RS13570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Ach5_RS13635	COG1492	cobalamin metabolic process
Ach5_RS13640	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Ach5_RS13650	COG4948	Mandelate Racemase Muconate Lactonizing
Ach5_RS13655	COG3254	rhamnose metabolic process
Ach5_RS13660	COG0246	Mannitol dehydrogenase
Ach5_RS13665	COG1063	alcohol dehydrogenase
Ach5_RS13685	COG4214	carbohydrate transport
Ach5_RS13690	COG1129	ABC transporter
Ach5_RS13695	COG2186	Transcriptional regulator
Ach5_RS13700	COG2721	sulfolactate sulfo-lyase activity
Ach5_RS13705	COG0138	bifunctional purine biosynthesis protein purh
Ach5_RS13715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ach5_RS13715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ach5_RS13720	COG0501	Belongs to the peptidase M48B family
Ach5_RS13740	COG0357	Ribosomal RNA small subunit methyltransferase G
Ach5_RS13745	COG0445	tRNA wobble uridine modification
Ach5_RS13750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ach5_RS13755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Ach5_RS13760	COG1981	membrane
Ach5_RS13765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Ach5_RS13935	COG0642	Histidine kinase
Ach5_RS14175	COG3064	Membrane
Ach5_RS14175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ach5_RS14375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Ach5_RS14630	COG0174	glutamine synthetase
Ach5_RS14675	COG1840	ABC-type Fe3 transport system, periplasmic component
Ach5_RS14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ach5_RS14900	COG0072	phenylalanine-tRNA ligase activity
Ach5_RS15065	COG0284	orotidine-5'-phosphate decarboxylase activity
Ach5_RS15415	COG2171	N-acyltransferase activity
Ach5_RS15460	COG0840	transmembrane signaling receptor activity
Ach5_RS15540	COG0166	Belongs to the GPI family
Ach5_RS15630	COG0573	inorganic phosphate transmembrane transporter activity
Ach5_RS15665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ach5_RS16120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Ach5_RS16635	COG1187	pseudouridine synthase activity
Ach5_RS16745	COG3158	transport of potassium into the cell
Ach5_RS16780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ach5_RS16955	COG0312	modulator of DNA gyrase
Ach5_RS17115	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Ach5_RS17265	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Ach5_RS17430	COG0656	L-ascorbic acid biosynthetic process
Ach5_RS17700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ach5_RS17920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ach5_RS18230	COG0346	lactoylglutathione lyase activity
Ach5_RS18320	COG5265	(ABC) transporter
Ach5_RS18685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ach5_RS18775	COG2814	Major facilitator Superfamily
Ach5_RS18890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ach5_RS19155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ach5_RS19365	COG0557	exoribonuclease II activity
Ach5_RS19875	COG2204	response regulator
Ach5_RS20115	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ach5_RS20160	COG0038	chloride channel
Ach5_RS20445	COG0326	Molecular chaperone. Has ATPase activity
Ach5_RS20525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ach5_RS20700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ach5_RS20775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ach5_RS20935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ach5_RS21035	COG0281	malic enzyme
Ach5_RS21035	COG0280	phosphate acetyltransferase
Ach5_RS21365	COG0525	valine-tRNA ligase activity
Ach5_RS21580	COG0174	glutamine synthetase
Ach5_RS21705	COG0679	Auxin Efflux Carrier
Ach5_RS21770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ach5_RS21970	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Ach5_RS22085	COG1131	(ABC) transporter
Ach5_RS22115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ach5_RS22350	COG0556	nucleotide-excision repair
Ach5_RS22420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ach5_RS22565	COG0330	HflC and HflK could
Ach5_RS22735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ach5_RS23260	COG1074	ATP-dependent DNA helicase activity
Ach5_RS23430	COG1643	Atp-dependent helicase
Ach5_RS23610	COG1185	polyribonucleotide nucleotidyltransferase activity
Ach5_RS23635	COG3064	Membrane
Ach5_RS23635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ach5_RS23715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ach5_RS23850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Ach5_RS23875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ach5_RS24040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ach5_RS24130	COG4172	Belongs to the ABC transporter superfamily
Ach5_RS24330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ach5_RS24390	COG1917	Cupin 2, conserved barrel domain protein
Ach5_RS24390	COG2169	Transcriptional regulator
Ach5_RS24495	COG1393	Belongs to the ArsC family
Ach5_RS24505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ach5_RS24505	COG0519	Catalyzes the synthesis of GMP from XMP
Ach5_RS24680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Ach5_RS24735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ach5_RS25220	COG0704	Plays a role in the regulation of phosphate uptake
Ach5_RS25345	COG1201	RNA secondary structure unwinding
Ach5_RS25540	COG0436	Aminotransferase
Ach5_RS25635	COG1157	protein secretion by the type III secretion system
Ach5_RS25820	COG0133	tryptophan synthase activity
Ach5_RS25835	COG1074	ATP-dependent DNA helicase activity
Ach5_RS25915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Ach5_RS26080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Ach5_RS26150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ach5_RS26150	COG3064	Membrane
Ach5_RS26200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ach5_RS26215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ach5_RS26280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ach5_RS26280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ach5_RS26325	COG0443	Heat shock 70 kDa protein
Ach5_RS26365	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ach5_RS26425	COG0070	glutamate synthase
Ach5_RS26425	COG0069	glutamate synthase activity
Ach5_RS26425	COG0067	glutamate synthase
Ach5_RS26760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Ach5_RS26850	COG4964	Belongs to the GSP D family
Ach5_RS26875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ach5_RS26920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ach5_RS27020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family