locus-tag	class	description
EML4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EML4_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EML4_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EML4_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EML4_RS00025	COG1420	regulation of RNA biosynthetic process
EML4_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EML4_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EML4_RS00050	COG1137	ATPase activity
EML4_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EML4_RS00065	COG0616	signal peptide processing
EML4_RS00070	COG0776	regulation of translation
EML4_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EML4_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EML4_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EML4_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EML4_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EML4_RS00115	COG0728	peptidoglycan biosynthetic process
EML4_RS00125	COG0180	Tryptophanyl-tRNA synthetase
EML4_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EML4_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
EML4_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EML4_RS00165	COG1702	phosphate starvation-inducible protein PhoH
EML4_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EML4_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EML4_RS00185	COG1396	sequence-specific DNA binding
EML4_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EML4_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EML4_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS00210	COG0242	peptide deformylase activity
EML4_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EML4_RS00220	COG0101	tRNA pseudouridine synthase activity
EML4_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4_RS00235	COG2171	N-acyltransferase activity
EML4_RS00245	COG0840	transmembrane signaling receptor activity
EML4_RS00250	COG1957	nucleoside hydrolase
EML4_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EML4_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EML4_RS00295	COG0706	membrane insertase activity
EML4_RS00300	COG0594	ribonuclease P activity
EML4_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EML4_RS00310	COG0840	transmembrane signaling receptor activity
EML4_RS00325	COG2226	methyltransferase
EML4_RS00330	COG3842	ATPase activity
EML4_RS00335	COG1175	transmembrane transport
EML4_RS00340	COG0395	ABC-type sugar transport system, permease component
EML4_RS00355	COG0427	acetyl-CoA hydrolase
EML4_RS00365	COG3938	Belongs to the proline racemase family
EML4_RS00370	COG0418	dihydroorotase activity
EML4_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EML4_RS00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EML4_RS00400	COG0166	Belongs to the GPI family
EML4_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
EML4_RS00410	COG3842	ATPase activity
EML4_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EML4_RS00425	COG4774	siderophore transport
EML4_RS00465	COG2815	serine threonine protein kinase
EML4_RS00465	COG0515	serine threonine protein kinase
EML4_RS00520	COG2326	polyphosphate kinase activity
EML4_RS00525	COG5002	protein histidine kinase activity
EML4_RS00530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EML4_RS00535	COG0573	inorganic phosphate transmembrane transporter activity
EML4_RS00545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EML4_RS00550	COG0704	Plays a role in the regulation of phosphate uptake
EML4_RS00555	COG0745	RESPONSE REGULATOR receiver
EML4_RS00565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EML4_RS00570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EML4_RS00580	COG2967	ApaG domain
EML4_RS00590	COG0717	Belongs to the dCTP deaminase family
EML4_RS00600	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EML4_RS00605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EML4_RS00655	COG0167	dihydroorotate dehydrogenase activity
EML4_RS00670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4_RS00690	COG1959	2 iron, 2 sulfur cluster binding
EML4_RS00695	COG1201	RNA secondary structure unwinding
EML4_RS00725	COG1960	acyl-CoA dehydrogenase activity
EML4_RS00730	COG0183	Belongs to the thiolase family
EML4_RS00735	COG1024	Enoyl-CoA hydratase
EML4_RS00735	COG1250	3-hydroxyacyl-CoA dehydrogenase
EML4_RS00760	COG1320	monovalent cation:proton antiporter activity
EML4_RS00765	COG2212	antiporter activity
EML4_RS00770	COG1863	multisubunit Na H antiporter MnhE subunit
EML4_RS00775	COG0651	ATP synthesis coupled electron transport
EML4_RS00780	COG1006	Multisubunit Na H antiporter MnhC subunit
EML4_RS00785	COG2111	Na H antiporter
EML4_RS00785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EML4_RS00795	COG0840	transmembrane signaling receptor activity
EML4_RS00805	COG0745	RESPONSE REGULATOR receiver
EML4_RS00810	COG2198	Histidine kinase
EML4_RS00810	COG0643	Histidine kinase
EML4_RS00815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EML4_RS00820	COG2201	protein-glutamate methylesterase activity
EML4_RS00825	COG0745	RESPONSE REGULATOR receiver
EML4_RS00830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EML4_RS00840	COG1766	The M ring may be actively involved in energy transduction
EML4_RS00845	COG2771	luxR family
EML4_RS00855	COG2972	Histidine kinase
EML4_RS00855	COG0840	transmembrane signaling receptor activity
EML4_RS00860	COG2205	protein histidine kinase activity
EML4_RS00860	COG0784	Response regulator, receiver
EML4_RS00860	COG2198	Histidine kinase
EML4_RS00865	COG1970	mechanosensitive ion channel activity
EML4_RS00870	COG0436	Aminotransferase
EML4_RS00885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EML4_RS00890	COG0424	maF-like protein
EML4_RS00895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EML4_RS00905	COG5328	Belongs to the UPF0262 family
EML4_RS00910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EML4_RS00920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EML4_RS00940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EML4_RS00950	COG1338	Plays a role in the flagellum-specific transport system
EML4_RS00960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EML4_RS00970	COG1706	bacterial-type flagellum-dependent cell motility
EML4_RS00975	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EML4_RS00980	COG4786	Flagellar basal body rod
EML4_RS00985	COG1677	Flagellar hook-basal body complex protein FliE
EML4_RS00990	COG1558	bacterial-type flagellum-dependent cell motility
EML4_RS00995	COG1815	bacterial-type flagellum-dependent cell motility
EML4_RS01005	COG1157	protein secretion by the type III secretion system
EML4_RS01010	COG4786	Flagellar basal body rod
EML4_RS01020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EML4_RS01025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4_RS01030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4_RS01035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4_RS01040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EML4_RS01060	COG1360	Flagellar Motor Protein
EML4_RS01105	COG5443	negative regulation of bacterial-type flagellum assembly
EML4_RS01110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EML4_RS01120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EML4_RS01160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EML4_RS01165	COG1609	Transcriptional regulator
EML4_RS01170	COG1653	transport
EML4_RS01175	COG1175	transmembrane transport
EML4_RS01180	COG0395	ABC-type sugar transport system, permease component
EML4_RS01185	COG0366	Alpha amylase catalytic
EML4_RS01190	COG3842	ATPase activity
EML4_RS01205	COG0129	dihydroxy-acid dehydratase activity
EML4_RS01210	COG0363	glucosamine-6-phosphate deaminase activity
EML4_RS01215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EML4_RS01220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS01230	COG2081	HI0933 family
EML4_RS01250	COG2224	Isocitrate lyase
EML4_RS01265	COG3842	ATPase activity
EML4_RS01270	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4_RS01275	COG1177	transmembrane transport
EML4_RS01285	COG2205	protein histidine kinase activity
EML4_RS01295	COG0248	Ppx GppA phosphatase
EML4_RS01300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EML4_RS01305	COG0477	Major facilitator Superfamily
EML4_RS01335	COG0521	Mo-molybdopterin cofactor biosynthetic process
EML4_RS01340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EML4_RS01350	COG0142	geranyltranstransferase activity
EML4_RS01375	COG0752	glycyl-tRNA synthetase alpha subunit
EML4_RS01385	COG1704	LemA family
EML4_RS01390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EML4_RS01400	COG0751	glycine-tRNA ligase activity
EML4_RS01405	COG1683	Conserved Protein
EML4_RS01410	COG0840	transmembrane signaling receptor activity
EML4_RS01420	COG0151	Belongs to the GarS family
EML4_RS01425	COG2183	response to ionizing radiation
EML4_RS01430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4_RS01455	COG0583	DNA-binding transcription factor activity
EML4_RS01475	COG0306	phosphate transporter
EML4_RS01485	COG0561	phosphatase activity
EML4_RS01490	COG0438	transferase activity, transferring glycosyl groups
EML4_RS01495	COG2186	Transcriptional regulator
EML4_RS01505	COG0583	DNA-binding transcription factor activity
EML4_RS01510	COG0277	FAD linked oxidase domain protein
EML4_RS01520	COG0247	lactate metabolic process
EML4_RS01530	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS01535	COG2818	Glycosylase
EML4_RS01545	COG2855	membrane
EML4_RS01550	COG0583	DNA-binding transcription factor activity
EML4_RS01580	COG0124	histidyl-tRNA synthetase
EML4_RS01590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EML4_RS01595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EML4_RS01600	COG2259	Doxx family
EML4_RS01610	COG0459	protein refolding
EML4_RS01615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EML4_RS01625	COG0196	riboflavin kinase activity
EML4_RS01630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EML4_RS01640	COG0590	tRNA wobble adenosine to inosine editing
EML4_RS01645	COG1187	pseudouridine synthase activity
EML4_RS01650	COG0742	ribosomal rna small subunit methyltransferase
EML4_RS01655	COG1752	Esterase of the alpha-beta hydrolase superfamily
EML4_RS01665	COG0312	modulator of DNA gyrase
EML4_RS01670	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS01680	COG1519	Transferase
EML4_RS01690	COG1663	tetraacyldisaccharide 4'-kinase activity
EML4_RS01705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EML4_RS01710	COG0745	RESPONSE REGULATOR receiver
EML4_RS01715	COG3300	MHYT domain
EML4_RS01715	COG5001	Diguanylate cyclase
EML4_RS01720	COG3386	PFAM SMP-30 Gluconolaconase
EML4_RS01725	COG0800	Aldolase
EML4_RS01730	COG3734	2-keto-3-deoxy-galactonokinase
EML4_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS01740	COG1414	Transcriptional regulator
EML4_RS01745	COG2197	response regulator
EML4_RS01760	COG0598	Magnesium transport protein CorA
EML4_RS01765	COG3158	transport of potassium into the cell
EML4_RS01780	COG0356	it plays a direct role in the translocation of protons across the membrane
EML4_RS01790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EML4_RS01795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EML4_RS01810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EML4_RS01830	COG0009	L-threonylcarbamoyladenylate synthase
EML4_RS01840	COG4638	Rieske (2fe-2S)
EML4_RS01865	COG1960	acyl-CoA dehydrogenase activity
EML4_RS01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EML4_RS01885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EML4_RS01890	COG0840	transmembrane signaling receptor activity
EML4_RS01900	COG1522	sequence-specific DNA binding
EML4_RS01925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EML4_RS01930	COG1741	Belongs to the pirin family
EML4_RS01935	COG1722	exodeoxyribonuclease VII activity
EML4_RS01940	COG0123	including yeast histone deacetylase and acetoin utilization protein
EML4_RS01945	COG1268	BioY protein
EML4_RS01950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EML4_RS01955	COG1122	ATPase activity
EML4_RS01960	COG3214	Protein conserved in bacteria
EML4_RS01965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4_RS01965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4_RS01970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EML4_RS01990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EML4_RS02005	COG0259	pyridoxamine-phosphate oxidase activity
EML4_RS02035	COG0312	modulator of DNA gyrase
EML4_RS02050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4_RS02055	COG0109	protoheme IX farnesyltransferase activity
EML4_RS02060	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EML4_RS02075	COG3346	SURF1 family
EML4_RS02080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EML4_RS02085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EML4_RS02090	COG0328	RNA-DNA hybrid ribonuclease activity
EML4_RS02100	COG0678	peroxiredoxin activity
EML4_RS02100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EML4_RS02110	COG1678	Uncharacterized ACR, COG1678
EML4_RS02115	COG3237	CsbD-like
EML4_RS02125	COG3300	MHYT domain
EML4_RS02125	COG5001	Diguanylate cyclase
EML4_RS02130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EML4_RS02135	COG0612	Peptidase, M16
EML4_RS02160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4_RS02165	COG1802	Transcriptional regulator
EML4_RS02180	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EML4_RS02185	COG3609	addiction module antidote protein, CC2985 family
EML4_RS02190	COG3668	Plasmid stabilization system
EML4_RS02200	COG1194	a g-specific adenine glycosylase
EML4_RS02215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EML4_RS02220	COG1196	nuclear chromosome segregation
EML4_RS02225	COG2514	catechol 2,3-dioxygenase activity
EML4_RS02230	COG0574	Belongs to the PEP-utilizing enzyme family
EML4_RS02230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EML4_RS02275	COG0579	oxidoreductase
EML4_RS02290	COG2895	sulfate adenylyltransferase (ATP) activity
EML4_RS02295	COG0175	sulfate reduction
EML4_RS02300	COG0175	sulfate reduction
EML4_RS02305	COG1959	2 iron, 2 sulfur cluster binding
EML4_RS02310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EML4_RS02315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EML4_RS02320	COG4208	sulfate ABC transporter
EML4_RS02325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EML4_RS02335	COG2200	EAL domain
EML4_RS02335	COG2203	Gaf domain
EML4_RS02335	COG2199	diguanylate cyclase activity
EML4_RS02345	COG1309	transcriptional regulator
EML4_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS02355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EML4_RS02390	COG0625	glutathione transferase activity
EML4_RS02400	COG0477	Major facilitator Superfamily
EML4_RS02410	COG1793	dna ligase
EML4_RS02410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EML4_RS02430	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS02435	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS02440	COG1846	Transcriptional regulator
EML4_RS02445	COG1764	response to oxidative stress
EML4_RS02460	COG0488	(ABC) transporter
EML4_RS02495	COG4221	oxidoreductase activity
EML4_RS02510	COG0433	COG0433 Predicted ATPase
EML4_RS02520	COG1733	regulation of RNA biosynthetic process
EML4_RS02525	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EML4_RS02540	COG0656	L-ascorbic acid biosynthetic process
EML4_RS02545	COG3781	membrane
EML4_RS02550	COG2378	regulation of single-species biofilm formation
EML4_RS02560	COG4106	trans-aconitate 2-methyltransferase activity
EML4_RS02565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4_RS02570	COG0840	transmembrane signaling receptor activity
EML4_RS02575	COG0583	DNA-binding transcription factor activity
EML4_RS02590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EML4_RS02610	COG3909	cytochrome
EML4_RS02615	COG2010	Cytochrome c
EML4_RS02645	COG0789	Transcriptional regulator
EML4_RS02670	COG4175	Glycine betaine
EML4_RS02670	COG0517	IMP dehydrogenase activity
EML4_RS02675	COG4176	ABC-type proline glycine betaine transport system permease component
EML4_RS02695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS02705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4_RS02705	COG2169	Transcriptional regulator
EML4_RS02715	COG2514	catechol 2,3-dioxygenase activity
EML4_RS02735	COG1272	protein, Hemolysin III
EML4_RS02745	COG1280	lysine exporter protein (LysE YggA)
EML4_RS02750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EML4_RS02760	COG2111	Na H antiporter
EML4_RS02765	COG1006	Multisubunit Na H antiporter MnhC subunit
EML4_RS02780	COG2212	antiporter activity
EML4_RS02785	COG1320	monovalent cation:proton antiporter activity
EML4_RS02790	COG4957	zinc ion binding
EML4_RS02805	COG2166	iron-sulfur cluster assembly
EML4_RS02815	COG2205	protein histidine kinase activity
EML4_RS02855	COG0583	DNA-binding transcription factor activity
EML4_RS02860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4_RS02865	COG2983	Belongs to the UPF0260 family
EML4_RS02875	COG3041	Addiction module toxin RelE StbE family
EML4_RS02880	COG3077	Addiction module antitoxin, RelB DinJ family
EML4_RS02885	COG2217	Heavy metal translocating P-type atpase
EML4_RS02915	COG2814	Major facilitator Superfamily
EML4_RS02925	COG1621	beta-fructofuranosidase activity
EML4_RS02930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EML4_RS02980	COG4695	Portal protein
EML4_RS03070	COG0745	RESPONSE REGULATOR receiver
EML4_RS03075	COG5002	protein histidine kinase activity
EML4_RS03085	COG4235	cytochrome complex assembly
EML4_RS03090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EML4_RS03095	COG1138	Cytochrome C-type biogenesis protein
EML4_RS03100	COG3088	subunit of a heme lyase
EML4_RS03105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4_RS03110	COG0745	RESPONSE REGULATOR receiver
EML4_RS03115	COG2205	protein histidine kinase activity
EML4_RS03120	COG3011	Protein conserved in bacteria
EML4_RS03125	COG3713	MltA-interacting MipA family protein
EML4_RS03130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EML4_RS03135	COG2205	protein histidine kinase activity
EML4_RS03135	COG2202	Pas domain
EML4_RS03145	COG0308	aminopeptidase N
EML4_RS03150	COG0697	spore germination
EML4_RS03165	COG0443	Heat shock 70 kDa protein
EML4_RS03200	COG0604	alcohol dehydrogenase
EML4_RS03205	COG1733	regulation of RNA biosynthetic process
EML4_RS03210	COG1968	undecaprenyl-diphosphatase activity
EML4_RS03215	COG2239	Acts as a magnesium transporter
EML4_RS03220	COG2814	Major facilitator Superfamily
EML4_RS03245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EML4_RS03275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EML4_RS03320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EML4_RS03325	COG0741	lytic transglycosylase activity
EML4_RS03330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS03335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EML4_RS03340	COG0840	transmembrane signaling receptor activity
EML4_RS03350	COG1758	RNA polymerase activity
EML4_RS03370	COG0736	holo-[acyl-carrier-protein] synthase activity
EML4_RS03375	COG0681	Belongs to the peptidase S26 family
EML4_RS03380	COG0571	ribonuclease III activity
EML4_RS03385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EML4_RS03395	COG0784	Response regulator, receiver
EML4_RS03400	COG1381	Involved in DNA repair and RecF pathway recombination
EML4_RS03410	COG2226	methyltransferase
EML4_RS03415	COG0633	Ferredoxin
EML4_RS03415	COG3217	Mosc domain protein beta barrel domain protein
EML4_RS03420	COG1418	mRNA catabolic process
EML4_RS03430	COG0346	lactoylglutathione lyase activity
EML4_RS03445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS03450	COG3443	Belongs to the bacterial solute-binding protein 9 family
EML4_RS03455	COG0668	transmembrane transport
EML4_RS03465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EML4_RS03495	COG1742	UPF0060 membrane protein
EML4_RS03510	COG1183	phosphatidylcholine synthase activity
EML4_RS03515	COG0688	phosphatidylethanolamine metabolic process
EML4_RS03520	COG5265	(ABC) transporter
EML4_RS03560	COG2852	Protein conserved in bacteria
EML4_RS03565	COG0215	cysteine-tRNA ligase activity
EML4_RS03570	COG4221	oxidoreductase activity
EML4_RS03575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EML4_RS03580	COG1286	toxin biosynthetic process
EML4_RS03600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EML4_RS03610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EML4_RS03620	COG0305	Participates in initiation and elongation during chromosome replication
EML4_RS03640	COG0359	binds to the 23S rRNA
EML4_RS03650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EML4_RS03655	COG0360	Binds together with S18 to 16S ribosomal RNA
EML4_RS03665	COG0667	Aldo Keto reductase
EML4_RS03670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EML4_RS03680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4_RS03685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4_RS03695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EML4_RS03700	COG1561	YicC-like family, N-terminal region
EML4_RS03705	COG0194	GDP metabolic process
EML4_RS03720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EML4_RS03725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EML4_RS03735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EML4_RS03750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EML4_RS03770	COG2203	Gaf domain
EML4_RS03770	COG3706	GGDEF domain
EML4_RS03770	COG4251	negative regulation of phosphorylation
EML4_RS03770	COG5001	Diguanylate cyclase
EML4_RS03775	COG3300	MHYT domain
EML4_RS03775	COG5001	Diguanylate cyclase
EML4_RS03780	COG4191	Histidine kinase
EML4_RS03785	COG4566	intracellular signal transduction
EML4_RS03795	COG0488	(ABC) transporter
EML4_RS03800	COG3706	GGDEF domain
EML4_RS03810	COG0105	UTP biosynthetic process
EML4_RS03830	COG0314	molybdopterin synthase activity
EML4_RS03840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EML4_RS03845	COG0322	excinuclease ABC activity
EML4_RS03850	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS03875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EML4_RS03880	COG0243	molybdopterin cofactor binding
EML4_RS03905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EML4_RS03910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EML4_RS03920	COG0628	permease
EML4_RS03930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EML4_RS03935	COG0248	Ppx GppA phosphatase
EML4_RS03960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EML4_RS03970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EML4_RS03975	COG0477	Major facilitator Superfamily
EML4_RS03980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EML4_RS03990	COG0840	transmembrane signaling receptor activity
EML4_RS03995	COG0659	secondary active sulfate transmembrane transporter activity
EML4_RS04005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EML4_RS04010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EML4_RS04020	COG0113	porphobilinogen synthase activity
EML4_RS04040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EML4_RS04045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EML4_RS04050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EML4_RS04050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EML4_RS04060	COG1280	lysine exporter protein (LysE YggA)
EML4_RS04065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EML4_RS04070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EML4_RS04075	COG2814	Major facilitator Superfamily
EML4_RS04080	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EML4_RS04100	COG0416	fatty acid biosynthetic process
EML4_RS04105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EML4_RS04110	COG0776	regulation of translation
EML4_RS04145	COG0601	transmembrane transport
EML4_RS04150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS04155	COG0444	Belongs to the ABC transporter superfamily
EML4_RS04165	COG0747	negative chemotaxis
EML4_RS04175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EML4_RS04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EML4_RS04195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EML4_RS04200	COG0583	DNA-binding transcription factor activity
EML4_RS04205	COG0737	Belongs to the 5'-nucleotidase family
EML4_RS04225	COG2897	thiosulfate sulfurtransferase activity
EML4_RS04240	COG0415	Belongs to the DNA photolyase family
EML4_RS04250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4_RS04280	COG3932	Exopolysaccharide synthesis, ExoD
EML4_RS04285	COG1238	metal cluster binding
EML4_RS04360	COG1612	heme a metabolic process
EML4_RS04370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EML4_RS04375	COG0010	Belongs to the arginase family
EML4_RS04380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EML4_RS04385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EML4_RS04395	COG1832	CoA-binding protein
EML4_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS04425	COG2124	cytochrome p450
EML4_RS04430	COG2199	diguanylate cyclase activity
EML4_RS04435	COG0740	serine-type endopeptidase activity
EML4_RS04440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EML4_RS04445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EML4_RS04455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EML4_RS04480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4_RS04485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4_RS04490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4_RS04500	COG0649	NAD binding
EML4_RS04510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EML4_RS04515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EML4_RS04525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EML4_RS04530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4_RS04540	COG0713	ATP synthesis coupled electron transport
EML4_RS04555	COG1007	ATP synthesis coupled electron transport
EML4_RS04560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EML4_RS04560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EML4_RS04575	COG0442	prolyl-tRNA aminoacylation
EML4_RS04585	COG1136	(ABC) transporter
EML4_RS04600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EML4_RS04620	COG0784	Response regulator, receiver
EML4_RS04630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EML4_RS04635	COG0477	Major facilitator Superfamily
EML4_RS04650	COG0557	exoribonuclease II activity
EML4_RS04655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EML4_RS04665	COG0758	DNA mediated transformation
EML4_RS04670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EML4_RS04680	COG0540	Belongs to the ATCase OTCase family
EML4_RS04695	COG1960	acyl-CoA dehydrogenase activity
EML4_RS04700	COG0456	acetyltransferase
EML4_RS04720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EML4_RS04725	COG2824	Alkylphosphonate utilization operon protein PhnA
EML4_RS04730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EML4_RS04735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EML4_RS04740	COG0154	amidase activity
EML4_RS04745	COG0456	acetyltransferase
EML4_RS04750	COG3811	Belongs to the UPF0386 family
EML4_RS04765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EML4_RS04775	COG0456	acetyltransferase
EML4_RS04795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EML4_RS04800	COG0439	Biotin carboxylase
EML4_RS04805	COG0511	ligase activity, forming carbon-carbon bonds
EML4_RS04810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EML4_RS04820	COG0436	Aminotransferase
EML4_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS04845	COG1530	ribonuclease E activity
EML4_RS04855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4_RS04875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EML4_RS04880	COG0384	phenazine biosynthesis protein PhzF
EML4_RS04900	COG0633	Ferredoxin
EML4_RS04910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EML4_RS04915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EML4_RS04920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EML4_RS04930	COG3768	UPF0283 membrane protein
EML4_RS04935	COG3106	COG3106 Predicted ATPase
EML4_RS04965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EML4_RS05000	COG0537	adenosine 5'-monophosphoramidase activity
EML4_RS05025	COG0052	Belongs to the universal ribosomal protein uS2 family
EML4_RS05030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EML4_RS05035	COG0528	UMP kinase activity
EML4_RS05040	COG0233	cytoplasmic translational termination
EML4_RS05045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EML4_RS05055	COG0750	zinc metalloprotease
EML4_RS05060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EML4_RS05065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4_RS05070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4_RS05075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4_RS05080	COG3494	Protein of unknown function (DUF1009)
EML4_RS05085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4_RS05090	COG2186	Transcriptional regulator
EML4_RS05100	COG0765	amino acid transport
EML4_RS05115	COG0372	Belongs to the citrate synthase family
EML4_RS05130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EML4_RS05140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EML4_RS05145	COG0148	phosphopyruvate hydratase activity
EML4_RS05155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EML4_RS05160	COG0022	dehydrogenase e1 component
EML4_RS05160	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4_RS05165	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4_RS05175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EML4_RS05185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EML4_RS05190	COG0697	spore germination
EML4_RS05210	COG2867	negative regulation of translational initiation
EML4_RS05215	COG1546	Belongs to the CinA family
EML4_RS05215	COG1058	Belongs to the CinA family
EML4_RS05220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EML4_RS05220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EML4_RS05230	COG3852	Histidine kinase
EML4_RS05235	COG2204	response regulator
EML4_RS05240	COG5000	phosphorelay sensor kinase activity
EML4_RS05245	COG2204	response regulator
EML4_RS05250	COG0569	domain protein
EML4_RS05255	COG1923	regulation of RNA biosynthetic process
EML4_RS05260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EML4_RS05265	COG3956	TIGRFAM MazG family protein
EML4_RS05275	COG1648	precorrin-2 dehydrogenase activity
EML4_RS05275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EML4_RS05315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EML4_RS05315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EML4_RS05320	COG0509	glycine decarboxylation via glycine cleavage system
EML4_RS05325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4_RS05350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EML4_RS05355	COG0564	pseudouridine synthase activity
EML4_RS05375	COG0251	oxidation-reduction process
EML4_RS05380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EML4_RS05390	COG1671	Belongs to the UPF0178 family
EML4_RS05405	COG0450	alkyl hydroperoxide reductase
EML4_RS05415	COG0625	glutathione transferase activity
EML4_RS05435	COG2826	transposase and inactivated derivatives, IS30 family
EML4_RS05440	COG0431	NADPH-dependent FMN reductase
EML4_RS05450	COG0798	PFAM Bile acid sodium symporter
EML4_RS05470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EML4_RS05470	COG0321	lipoyl(octanoyl) transferase activity
EML4_RS05475	COG0084	hydrolase, TatD family'
EML4_RS05480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4_RS05490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EML4_RS05545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EML4_RS05550	COG2095	MarC family integral membrane protein
EML4_RS05555	COG0517	IMP dehydrogenase activity
EML4_RS05555	COG0617	tRNA 3'-terminal CCA addition
EML4_RS05555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EML4_RS05565	COG0629	single-stranded DNA binding
EML4_RS05570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EML4_RS05580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EML4_RS05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4_RS05605	COG1121	(ABC) transporter
EML4_RS05625	COG0667	Aldo Keto reductase
EML4_RS05635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EML4_RS05715	COG2239	Acts as a magnesium transporter
EML4_RS05720	COG0243	molybdopterin cofactor binding
EML4_RS05730	COG0242	peptide deformylase activity
EML4_RS05745	COG2205	protein histidine kinase activity
EML4_RS05745	COG2202	Pas domain
EML4_RS05755	COG0321	lipoyl(octanoyl) transferase activity
EML4_RS05760	COG1064	alcohol dehydrogenase
EML4_RS05790	COG1862	Preprotein translocase
EML4_RS05810	COG2124	cytochrome p450
EML4_RS05825	COG0596	Alpha beta hydrolase
EML4_RS05835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4_RS05840	COG0626	cystathionine gamma-synthase activity
EML4_RS05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS05850	COG4597	amino acid ABC transporter
EML4_RS05855	COG0765	amino acid transport
EML4_RS05860	COG1126	abc transporter atp-binding protein
EML4_RS05880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EML4_RS05895	COG0436	Aminotransferase
EML4_RS05925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4_RS05935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4_RS05940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4_RS05945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EML4_RS05960	COG3243	poly(R)-hydroxyalkanoic acid synthase
EML4_RS05965	COG1489	DNA binding
EML4_RS05970	COG0024	Methionine aminopeptidase
EML4_RS05990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EML4_RS06015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EML4_RS06020	COG0546	phosphoglycolate phosphatase activity
EML4_RS06030	COG0114	fumarate hydratase activity
EML4_RS06040	COG0504	CTP synthase activity
EML4_RS06050	COG0149	triose-phosphate isomerase activity
EML4_RS06060	COG0187	DNA topoisomerase II activity
EML4_RS06070	COG0740	serine-type endopeptidase activity
EML4_RS06080	COG0640	Transcriptional regulator
EML4_RS06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EML4_RS06090	COG0745	RESPONSE REGULATOR receiver
EML4_RS06110	COG3264	Mechanosensitive ion channel
EML4_RS06110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EML4_RS06175	COG1127	ABC transporter
EML4_RS06180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EML4_RS06185	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS06195	COG0280	phosphate acetyltransferase
EML4_RS06195	COG0281	malic enzyme
EML4_RS06205	COG0778	Nitroreductase
EML4_RS06210	COG0823	Involved in the tonB-independent uptake of proteins
EML4_RS06225	COG1368	sulfuric ester hydrolase activity
EML4_RS06250	COG0544	peptidyl-prolyl cis-trans isomerase activity
EML4_RS06270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EML4_RS06290	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EML4_RS06305	COG0318	PFAM AMP-dependent synthetase and ligase
EML4_RS06315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EML4_RS06315	COG0512	Glutamine amidotransferase of anthranilate synthase
EML4_RS06320	COG0343	queuine tRNA-ribosyltransferase activity
EML4_RS06325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EML4_RS06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EML4_RS06355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EML4_RS06360	COG0134	indole-3-glycerol-phosphate synthase activity
EML4_RS06365	COG0315	cyclic pyranopterin monophosphate synthase activity
EML4_RS06370	COG0303	'Molybdopterin
EML4_RS06375	COG3706	GGDEF domain
EML4_RS06385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EML4_RS06385	COG0475	glutathione-regulated potassium exporter activity
EML4_RS06395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EML4_RS06405	COG2814	Major facilitator Superfamily
EML4_RS06410	COG0746	molybdenum cofactor guanylyltransferase activity
EML4_RS06415	COG1763	Mo-molybdopterin cofactor biosynthetic process
EML4_RS06420	COG0739	heme binding
EML4_RS06425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EML4_RS06430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EML4_RS06435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EML4_RS06440	COG0805	protein transport
EML4_RS06445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EML4_RS06450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EML4_RS06455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EML4_RS06460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EML4_RS06465	COG1472	Belongs to the glycosyl hydrolase 3 family
EML4_RS06475	COG0018	arginyl-trna synthetase
EML4_RS06480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EML4_RS06505	COG0525	valine-tRNA ligase activity
EML4_RS06515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EML4_RS06545	COG0655	NAD(P)H dehydrogenase (quinone) activity
EML4_RS06550	COG1058	Belongs to the CinA family
EML4_RS06550	COG1546	Belongs to the CinA family
EML4_RS06555	COG0589	response to stress
EML4_RS06560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EML4_RS06570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EML4_RS06580	COG0640	Transcriptional regulator
EML4_RS06585	COG1914	H( )-stimulated, divalent metal cation uptake system
EML4_RS06595	COG1132	(ABC) transporter
EML4_RS06600	COG0628	permease
EML4_RS06635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EML4_RS06645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EML4_RS06655	COG0302	gtp cyclohydrolase
EML4_RS06660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EML4_RS06665	COG1752	Esterase of the alpha-beta hydrolase superfamily
EML4_RS06675	COG0516	GMP reductase activity
EML4_RS06675	COG0517	IMP dehydrogenase activity
EML4_RS06710	COG1760	l-serine dehydratase
EML4_RS06745	COG0583	DNA-binding transcription factor activity
EML4_RS06760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EML4_RS06760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EML4_RS06770	COG0347	Belongs to the P(II) protein family
EML4_RS06775	COG0174	glutamine synthetase
EML4_RS06805	COG0697	spore germination
EML4_RS06815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EML4_RS06825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EML4_RS06855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EML4_RS06865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EML4_RS06870	COG2186	Transcriptional regulator
EML4_RS06890	COG1129	ABC transporter
EML4_RS06895	COG1183	phosphatidylcholine synthase activity
EML4_RS06900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4_RS06905	COG0679	Auxin Efflux Carrier
EML4_RS06910	COG0785	Cytochrome C biogenesis protein
EML4_RS06930	COG1278	Cold shock
EML4_RS06995	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EML4_RS07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4_RS07110	COG3685	Protein conserved in bacteria
EML4_RS07125	COG0393	Putative heavy-metal-binding
EML4_RS07185	COG0616	signal peptide processing
EML4_RS07240	COG2815	serine threonine protein kinase
EML4_RS07240	COG0515	serine threonine protein kinase
EML4_RS07250	COG3237	CsbD-like
EML4_RS07260	COG0270	DNA (cytosine-5-)-methyltransferase activity
EML4_RS07290	COG1061	Type III restriction enzyme res subunit
EML4_RS07405	COG0582	viral genome integration into host DNA
EML4_RS07425	COG1136	(ABC) transporter
EML4_RS07425	COG0577	efflux transmembrane transporter activity
EML4_RS07430	COG0577	efflux transmembrane transporter activity
EML4_RS07430	COG1136	(ABC) transporter
EML4_RS07455	COG2151	metal-sulfur cluster biosynthetic enzyme
EML4_RS07460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EML4_RS07465	COG0719	Fe-S assembly protein
EML4_RS07470	COG0396	ATPase activity
EML4_RS07475	COG0719	Fe-S assembly protein
EML4_RS07480	COG1104	cysteine desulfurase activity
EML4_RS07485	COG2945	thiolester hydrolase activity
EML4_RS07490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EML4_RS07495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EML4_RS07505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EML4_RS07510	COG2833	Protein of unknown function (DUF455)
EML4_RS07515	COG0739	heme binding
EML4_RS07520	COG0513	Belongs to the DEAD box helicase family
EML4_RS07545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EML4_RS07555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EML4_RS07560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EML4_RS07565	COG0047	phosphoribosylformylglycinamidine synthase activity
EML4_RS07580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4_RS07585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EML4_RS07610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EML4_RS07615	COG2814	Major facilitator Superfamily
EML4_RS07620	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS07625	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS07630	COG0037	tRNA processing
EML4_RS07635	COG2066	Belongs to the glutaminase family
EML4_RS07640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EML4_RS07645	COG0861	Integral membrane protein TerC family
EML4_RS07660	COG1280	lysine exporter protein (LysE YggA)
EML4_RS07670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EML4_RS07675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EML4_RS07685	COG0538	isocitrate dehydrogenase activity
EML4_RS07695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EML4_RS07700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EML4_RS07705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS07710	COG2313	pseudouridylate synthase activity
EML4_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS07725	COG4215	(ABC) transporter
EML4_RS07735	COG5425	PFAM Usg family protein
EML4_RS07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS07750	COG1522	sequence-specific DNA binding
EML4_RS07755	COG1573	uracil-dna glycosylase
EML4_RS07765	COG2202	Pas domain
EML4_RS07765	COG2205	protein histidine kinase activity
EML4_RS07770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EML4_RS07775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EML4_RS07780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EML4_RS07795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4_RS07800	COG0842	Transport permease protein
EML4_RS07805	COG1131	(ABC) transporter
EML4_RS07810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4_RS07810	COG0730	response to heat
EML4_RS07830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EML4_RS07835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4_RS07855	COG0129	dihydroxy-acid dehydratase activity
EML4_RS07860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EML4_RS07865	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EML4_RS07875	COG3739	integral membrane protein
EML4_RS07885	COG0203	ribosomal protein L17
EML4_RS07890	COG0202	RNA polymerase activity
EML4_RS07895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EML4_RS07900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EML4_RS07905	COG0563	adenylate kinase activity
EML4_RS07910	COG0201	protein transport
EML4_RS07915	COG0200	Binds to the 23S rRNA
EML4_RS07920	COG1841	ribosomal large subunit assembly
EML4_RS07925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EML4_RS07930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EML4_RS07935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EML4_RS07940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EML4_RS07945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EML4_RS07950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EML4_RS07955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EML4_RS07960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EML4_RS07965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EML4_RS07970	COG0255	Belongs to the universal ribosomal protein uL29 family
EML4_RS07975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EML4_RS07980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EML4_RS07985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EML4_RS07990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EML4_RS07995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EML4_RS08000	COG0089	rRNA binding
EML4_RS08005	COG0088	Forms part of the polypeptide exit tunnel
EML4_RS08010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EML4_RS08015	COG0051	transcription antitermination factor activity, RNA binding
EML4_RS08020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EML4_RS08025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EML4_RS08030	COG0049	tRNA binding
EML4_RS08035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EML4_RS08055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EML4_RS08060	COG0085	RNA polymerase activity
EML4_RS08065	COG0222	ribosome binding
EML4_RS08070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EML4_RS08075	COG0081	regulation of translation
EML4_RS08080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EML4_RS08090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EML4_RS08100	COG1086	Polysaccharide biosynthesis protein
EML4_RS08105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EML4_RS08110	COG0861	Integral membrane protein TerC family
EML4_RS08135	COG1132	(ABC) transporter
EML4_RS08140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4_RS08160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4_RS08195	COG0784	Response regulator, receiver
EML4_RS08195	COG2205	protein histidine kinase activity
EML4_RS08195	COG2198	Histidine kinase
EML4_RS08195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS08200	COG0784	Response regulator, receiver
EML4_RS08205	COG3920	Histidine kinase
EML4_RS08205	COG2202	Pas domain
EML4_RS08210	COG0784	Response regulator, receiver
EML4_RS08215	COG4251	negative regulation of phosphorylation
EML4_RS08230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EML4_RS08235	COG1607	acyl-coa hydrolase
EML4_RS08255	COG2910	NAD(P)H-binding
EML4_RS08260	COG1733	regulation of RNA biosynthetic process
EML4_RS08275	COG0556	nucleotide-excision repair
EML4_RS08285	COG2382	esterase
EML4_RS08305	COG0484	heat shock protein binding
EML4_RS08325	COG3706	GGDEF domain
EML4_RS08345	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4_RS08350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4_RS08365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EML4_RS08375	COG2207	Transcriptional regulator
EML4_RS08380	COG1064	alcohol dehydrogenase
EML4_RS08385	COG1252	NADH dehydrogenase
EML4_RS08390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EML4_RS08395	COG2197	response regulator
EML4_RS08400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EML4_RS08435	COG0656	L-ascorbic acid biosynthetic process
EML4_RS08450	COG0440	acetolactate synthase activity
EML4_RS08455	COG0028	Belongs to the TPP enzyme family
EML4_RS08470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EML4_RS08475	COG3830	Belongs to the UPF0237 family
EML4_RS08475	COG0560	Phosphoserine phosphatase
EML4_RS08495	COG0330	HflC and HflK could
EML4_RS08500	COG0330	HflC and HflK could
EML4_RS08510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EML4_RS08545	COG0277	FAD linked oxidase domain protein
EML4_RS08550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4_RS08590	COG1335	isochorismatase
EML4_RS08620	COG2264	protein methyltransferase activity
EML4_RS08625	COG1999	signal sequence binding
EML4_RS08635	COG0835	chemotaxis
EML4_RS08645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EML4_RS08650	COG0583	DNA-binding transcription factor activity
EML4_RS08660	COG1247	-acetyltransferase
EML4_RS08670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EML4_RS08675	COG0497	DNA recombination
EML4_RS08680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EML4_RS08690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EML4_RS08695	COG0849	cell division
EML4_RS08700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EML4_RS08705	COG1181	Belongs to the D-alanine--D-alanine ligase family
EML4_RS08710	COG0477	Major facilitator Superfamily
EML4_RS08720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EML4_RS08725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EML4_RS08730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EML4_RS08740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EML4_RS08745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EML4_RS08755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EML4_RS08770	COG0275	rRNA processing
EML4_RS08775	COG2001	Belongs to the MraZ family
EML4_RS08800	COG3023	N-Acetylmuramoyl-L-alanine amidase
EML4_RS08830	COG4106	trans-aconitate 2-methyltransferase activity
EML4_RS08850	COG2226	methyltransferase
EML4_RS08860	COG2267	carboxylic ester hydrolase activity
EML4_RS08865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EML4_RS08895	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS08900	COG2814	Major facilitator Superfamily
EML4_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS08940	COG0174	glutamine synthetase
EML4_RS08945	COG0531	amino acid
EML4_RS08960	COG2182	Extracellular solute-binding protein
EML4_RS08975	COG3842	ATPase activity
EML4_RS09035	COG2968	Membrane
EML4_RS09045	COG0432	Pfam Uncharacterised protein family UPF0047
EML4_RS09060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EML4_RS09065	COG0358	DNA primase activity
EML4_RS09085	COG0505	Belongs to the CarA family
EML4_RS09090	COG0534	Mate efflux family protein
EML4_RS09105	COG2321	neutral zinc metallopeptidase
EML4_RS09120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EML4_RS09130	COG3706	GGDEF domain
EML4_RS09145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EML4_RS09155	COG1522	sequence-specific DNA binding
EML4_RS09160	COG0492	ferredoxin-NADP+ reductase activity
EML4_RS09165	COG0583	DNA-binding transcription factor activity
EML4_RS09175	COG1902	pentaerythritol trinitrate reductase activity
EML4_RS09200	COG0387	Pfam Sodium calcium exchanger
EML4_RS09205	COG0436	Aminotransferase
EML4_RS09210	COG2200	EAL domain
EML4_RS09210	COG2199	diguanylate cyclase activity
EML4_RS09225	COG1278	Cold shock
EML4_RS09230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4_RS09240	COG1846	Transcriptional regulator
EML4_RS09245	COG0745	RESPONSE REGULATOR receiver
EML4_RS09250	COG2205	protein histidine kinase activity
EML4_RS09255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4_RS09275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EML4_RS09300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EML4_RS09310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EML4_RS09325	COG0840	transmembrane signaling receptor activity
EML4_RS09330	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS09335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EML4_RS09340	COG5001	Diguanylate cyclase
EML4_RS09340	COG3300	MHYT domain
EML4_RS09345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EML4_RS09350	COG5001	Diguanylate cyclase
EML4_RS09360	COG0193	aminoacyl-tRNA hydrolase activity
EML4_RS09370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EML4_RS09395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EML4_RS09405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EML4_RS09405	COG2857	Cytochrome c1
EML4_RS09425	COG1132	(ABC) transporter
EML4_RS09430	COG1132	(ABC) transporter
EML4_RS09440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EML4_RS09455	COG0408	coproporphyrinogen oxidase activity
EML4_RS09470	COG0617	tRNA 3'-terminal CCA addition
EML4_RS09485	COG0714	Associated with various cellular activities
EML4_RS09505	COG0454	-acetyltransferase
EML4_RS09520	COG0477	Major facilitator Superfamily
EML4_RS09530	COG0435	Glutathione S-transferase
EML4_RS09535	COG0494	nUDIX hydrolase
EML4_RS09545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EML4_RS09550	COG3135	benzoate transporter
EML4_RS09575	COG0740	serine-type endopeptidase activity
EML4_RS09590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EML4_RS09595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EML4_RS09620	COG4175	Glycine betaine
EML4_RS09640	COG1435	thymidine kinase activity
EML4_RS09665	COG1629	transport
EML4_RS09665	COG4771	TonB-dependent receptor
EML4_RS09675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EML4_RS09675	COG0512	Glutamine amidotransferase of anthranilate synthase
EML4_RS09690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EML4_RS09700	COG0366	Alpha amylase catalytic
EML4_RS09705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS09725	COG1160	GTP binding
EML4_RS09745	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EML4_RS09755	COG0024	Methionine aminopeptidase
EML4_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS09775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EML4_RS09785	COG0583	DNA-binding transcription factor activity
EML4_RS09800	COG0402	S-adenosylhomocysteine deaminase activity
EML4_RS09820	COG1309	transcriptional regulator
EML4_RS09825	COG1686	Belongs to the peptidase S11 family
EML4_RS09835	COG2351	hydroxyisourate hydrolase activity
EML4_RS09840	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EML4_RS09855	COG3195	allantoin biosynthetic process
EML4_RS09855	COG3648	Uricase
EML4_RS09865	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4_RS09875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS09875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EML4_RS09885	COG0513	Belongs to the DEAD box helicase family
EML4_RS09900	COG2259	Doxx family
EML4_RS09905	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS09915	COG2308	Evidence 4 Homologs of previously reported genes of
EML4_RS09925	COG1305	Transglutaminase-like
EML4_RS09955	COG4214	carbohydrate transport
EML4_RS09960	COG1129	ABC transporter
EML4_RS09965	COG4213	ABC transporter substrate-binding protein
EML4_RS10095	COG0646	methionine synthase
EML4_RS10095	COG1410	methionine synthase
EML4_RS10140	COG1215	transferase activity, transferring glycosyl groups
EML4_RS10170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EML4_RS10195	COG1309	transcriptional regulator
EML4_RS10210	COG0494	nUDIX hydrolase
EML4_RS10220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS10225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS10255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EML4_RS10260	COG0830	nickel cation binding
EML4_RS10265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EML4_RS10280	COG0804	urea catabolic process
EML4_RS10285	COG1442	glycosyl transferase family 8
EML4_RS10300	COG0832	Belongs to the urease beta subunit family
EML4_RS10305	COG3813	Protein conserved in bacteria
EML4_RS10310	COG0831	urea catabolic process
EML4_RS10315	COG0829	nickel cation binding
EML4_RS10345	COG0559	Belongs to the binding-protein-dependent transport system permease family
EML4_RS10360	COG0174	glutamine synthetase
EML4_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS10370	COG5002	protein histidine kinase activity
EML4_RS10370	COG0784	Response regulator, receiver
EML4_RS10370	COG2198	Histidine kinase
EML4_RS10385	COG0726	polysaccharide deacetylase
EML4_RS10420	COG1218	3'(2'),5'-bisphosphate nucleotidase
EML4_RS10495	COG0564	pseudouridine synthase activity
EML4_RS10505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EML4_RS10515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EML4_RS10540	COG0346	lactoylglutathione lyase activity
EML4_RS10550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EML4_RS10560	COG2832	Protein of unknown function (DUF454)
EML4_RS10565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EML4_RS10570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS10575	COG4558	Periplasmic binding protein
EML4_RS10585	COG3721	Heme iron utilization protein
EML4_RS10600	COG3655	Transcriptional regulator
EML4_RS10615	COG3657	addiction module killer protein
EML4_RS10625	COG2205	protein histidine kinase activity
EML4_RS10670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS10675	COG4605	iron ion homeostasis
EML4_RS10680	COG4604	ABC transporter, ATP-binding protein
EML4_RS10685	COG0783	Belongs to the Dps family
EML4_RS10700	COG2972	Histidine kinase
EML4_RS10700	COG0840	transmembrane signaling receptor activity
EML4_RS10705	COG0656	L-ascorbic acid biosynthetic process
EML4_RS10710	COG2814	Major facilitator Superfamily
EML4_RS10720	COG0583	DNA-binding transcription factor activity
EML4_RS10730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS10750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EML4_RS10755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EML4_RS10760	COG0288	reversible hydration of carbon dioxide
EML4_RS10770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EML4_RS10790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EML4_RS10795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4_RS10800	COG0778	Nitroreductase
EML4_RS10805	COG2267	carboxylic ester hydrolase activity
EML4_RS10810	COG0251	oxidation-reduction process
EML4_RS10815	COG1335	isochorismatase
EML4_RS10820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS10830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS10845	COG1175	transmembrane transport
EML4_RS10850	COG0395	ABC-type sugar transport system, permease component
EML4_RS10855	COG3842	ATPase activity
EML4_RS10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS10870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4_RS10885	COG4608	Belongs to the ABC transporter superfamily
EML4_RS10890	COG0444	Belongs to the ABC transporter superfamily
EML4_RS10900	COG0601	transmembrane transport
EML4_RS10955	COG2159	amidohydrolase
EML4_RS10960	COG1960	acyl-CoA dehydrogenase activity
EML4_RS10990	COG0745	RESPONSE REGULATOR receiver
EML4_RS11000	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4_RS11000	COG1902	pentaerythritol trinitrate reductase activity
EML4_RS11005	COG3842	ATPase activity
EML4_RS11015	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4_RS11020	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4_RS11025	COG0745	RESPONSE REGULATOR receiver
EML4_RS11035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EML4_RS11040	COG0583	DNA-binding transcription factor activity
EML4_RS11045	COG1278	Cold shock
EML4_RS11050	COG4372	Transposase
EML4_RS11055	COG3436	PFAM IS66 Orf2 family protein
EML4_RS11095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EML4_RS11100	COG1309	transcriptional regulator
EML4_RS11105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS11110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4_RS11120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EML4_RS11125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EML4_RS11145	COG0583	DNA-binding transcription factor activity
EML4_RS11150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS11155	COG0725	ABC transporter, periplasmic molybdate-binding protein
EML4_RS11160	COG4149	molybdate abc transporter
EML4_RS11165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EML4_RS11180	COG2022	thiamine diphosphate biosynthetic process
EML4_RS11195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EML4_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4_RS11210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EML4_RS11230	COG1132	(ABC) transporter
EML4_RS11235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EML4_RS11280	COG4166	transmembrane transport
EML4_RS11285	COG0601	transmembrane transport
EML4_RS11290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS11305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EML4_RS11310	COG3142	Participates in the control of copper homeostasis
EML4_RS11315	COG2814	Major facilitator Superfamily
EML4_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS11335	COG1737	Transcriptional regulator
EML4_RS11345	COG3842	ATPase activity
EML4_RS11355	COG0395	ABC-type sugar transport system, permease component
EML4_RS11375	COG2188	Transcriptional regulator
EML4_RS11380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EML4_RS11385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EML4_RS11390	COG1940	carbohydrate kinase activity
EML4_RS11400	COG0671	phosphoesterase, PA-phosphatase related
EML4_RS11405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EML4_RS11410	COG0156	8-amino-7-oxononanoate synthase activity
EML4_RS11420	COG0729	surface antigen
EML4_RS11430	COG0835	chemotaxis
EML4_RS11440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EML4_RS11445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EML4_RS11450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EML4_RS11455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EML4_RS11460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EML4_RS11465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EML4_RS11480	COG4974	Belongs to the 'phage' integrase family
EML4_RS11505	COG1280	lysine exporter protein (LysE YggA)
EML4_RS11515	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4_RS11520	COG0567	Dehydrogenase, E1 component
EML4_RS11525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EML4_RS11530	COG0045	succinate-CoA ligase (ADP-forming) activity
EML4_RS11535	COG0039	L-malate dehydrogenase activity
EML4_RS11540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EML4_RS11575	COG2264	protein methyltransferase activity
EML4_RS11590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EML4_RS11595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EML4_RS11600	COG0181	hydroxymethylbilane synthase activity
EML4_RS11640	COG1872	DUF167
EML4_RS11645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EML4_RS11660	COG0339	signal peptide processing
EML4_RS11665	COG1846	Transcriptional regulator
EML4_RS11675	COG0137	argininosuccinate synthase activity
EML4_RS11685	COG1280	lysine exporter protein (LysE YggA)
EML4_RS11690	COG1122	ATPase activity
EML4_RS11695	COG4120	Belongs to the binding-protein-dependent transport system permease family
EML4_RS11705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EML4_RS11720	COG2154	pterin-4-alpha-carbinolamine dehydratase
EML4_RS11725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EML4_RS11730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EML4_RS11740	COG4181	ATPase activity
EML4_RS11750	COG0670	Belongs to the BI1 family
EML4_RS11765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EML4_RS11770	COG4133	protoheme IX ABC transporter activity
EML4_RS11775	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EML4_RS11780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EML4_RS11795	COG3706	GGDEF domain
EML4_RS11805	COG2917	probably involved in intracellular septation
EML4_RS11810	COG0552	protein localization to endoplasmic reticulum
EML4_RS11815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EML4_RS11820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EML4_RS11835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EML4_RS11840	COG1605	Chorismate mutase
EML4_RS11840	COG0287	Prephenate dehydrogenase
EML4_RS11845	COG0228	four-way junction DNA binding
EML4_RS11850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EML4_RS11855	COG0336	Belongs to the RNA methyltransferase TrmD family
EML4_RS11865	COG0335	large ribosomal subunit rRNA binding
EML4_RS11870	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EML4_RS11875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS11890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EML4_RS11910	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EML4_RS11940	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EML4_RS11950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EML4_RS11955	COG0142	geranyltranstransferase activity
EML4_RS11960	COG2885	chlorophyll binding
EML4_RS11965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EML4_RS11970	COG2223	nitrite transmembrane transporter activity
EML4_RS11975	COG1349	DNA-binding transcription factor activity
EML4_RS11980	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EML4_RS11985	COG2197	response regulator
EML4_RS11990	COG1132	(ABC) transporter
EML4_RS11995	COG3459	Glycosyltransferase 36 associated
EML4_RS12000	COG1473	amidohydrolase
EML4_RS12010	COG0579	oxidoreductase
EML4_RS12020	COG0129	dihydroxy-acid dehydratase activity
EML4_RS12025	COG2084	Dehydrogenase
EML4_RS12030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS12035	COG0277	FAD linked oxidase domain protein
EML4_RS12040	COG2186	Transcriptional regulator
EML4_RS12050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EML4_RS12055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4_RS12060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS12065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EML4_RS12075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EML4_RS12080	COG0495	leucyl-tRNA aminoacylation
EML4_RS12095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EML4_RS12100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EML4_RS12115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4_RS12120	COG1946	Acyl-CoA thioesterase
EML4_RS12125	COG0347	Belongs to the P(II) protein family
EML4_RS12130	COG0004	ammonium transporteR
EML4_RS12135	COG1674	ftsk spoiiie
EML4_RS12140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EML4_RS12155	COG0745	RESPONSE REGULATOR receiver
EML4_RS12165	COG1329	Transcriptional regulator
EML4_RS12175	COG2270	Major facilitator Superfamily
EML4_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS12205	COG0494	nUDIX hydrolase
EML4_RS12210	COG2861	carbohydrate metabolic process
EML4_RS12215	COG0793	Belongs to the peptidase S41A family
EML4_RS12225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EML4_RS12230	COG0799	negative regulation of ribosome biogenesis
EML4_RS12235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EML4_RS12240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EML4_RS12245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EML4_RS12250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EML4_RS12265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EML4_RS12270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EML4_RS12295	COG0066	3-isopropylmalate dehydratase activity
EML4_RS12300	COG0473	3-isopropylmalate dehydrogenase activity
EML4_RS12305	COG1858	cytochrome C peroxidase
EML4_RS12310	COG1797	cobyrinic acid a,c-diamide synthase activity
EML4_RS12320	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EML4_RS12385	COG1492	cobalamin metabolic process
EML4_RS12400	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS12405	COG3254	rhamnose metabolic process
EML4_RS12410	COG0246	Mannitol dehydrogenase
EML4_RS12415	COG1063	alcohol dehydrogenase
EML4_RS12440	COG1129	ABC transporter
EML4_RS12445	COG2186	Transcriptional regulator
EML4_RS12450	COG2721	sulfolactate sulfo-lyase activity
EML4_RS12455	COG0138	bifunctional purine biosynthesis protein purh
EML4_RS12465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EML4_RS12465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EML4_RS12470	COG0501	Belongs to the peptidase M48B family
EML4_RS12490	COG0357	Ribosomal RNA small subunit methyltransferase G
EML4_RS12495	COG0445	tRNA wobble uridine modification
EML4_RS12500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EML4_RS12505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EML4_RS12515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EML4_RS12520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EML4_RS12525	COG0424	maF-like protein
EML4_RS12530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EML4_RS12535	COG0237	dephospho-CoA kinase activity
EML4_RS12545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EML4_RS12550	COG3030	protein affecting phage T7 exclusion by the F plasmid
EML4_RS12560	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EML4_RS12585	COG0179	Fumarylacetoacetate (FAA) hydrolase
EML4_RS12600	COG0135	phosphoribosylanthranilate isomerase activity
EML4_RS12605	COG0133	tryptophan synthase activity
EML4_RS12610	COG0159	tryptophan synthase activity
EML4_RS12615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EML4_RS12630	COG1074	ATP-dependent DNA helicase activity
EML4_RS12640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EML4_RS12645	COG0802	atpase or kinase
EML4_RS12650	COG2205	protein histidine kinase activity
EML4_RS12655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EML4_RS12660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4_RS12665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EML4_RS12665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4_RS12670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EML4_RS12675	COG0642	Histidine kinase
EML4_RS12680	COG0745	RESPONSE REGULATOR receiver
EML4_RS12685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EML4_RS12695	COG1652	LysM domain
EML4_RS12700	COG1072	(Pantothenic acid kinase))
EML4_RS12705	COG0140	phosphoribosyl-ATP diphosphatase activity
EML4_RS12710	COG0107	imidazoleglycerol-phosphate synthase activity
EML4_RS12715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EML4_RS12720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EML4_RS12730	COG0131	Imidazoleglycerol-phosphate dehydratase
EML4_RS12735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EML4_RS12740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EML4_RS12750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EML4_RS12765	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EML4_RS12775	COG1643	Atp-dependent helicase
EML4_RS12815	COG1940	carbohydrate kinase activity
EML4_RS12835	COG1072	(Pantothenic acid kinase))
EML4_RS12845	COG1780	Probably involved in ribonucleotide reductase function
EML4_RS12865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EML4_RS12895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS12905	COG2813	Specifically methylates the guanine in position
EML4_RS12910	COG1185	polyribonucleotide nucleotidyltransferase activity
EML4_RS12915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EML4_RS12920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EML4_RS12925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EML4_RS12930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EML4_RS12930	COG3064	Membrane
EML4_RS12945	COG0779	Required for maturation of 30S ribosomal subunits
EML4_RS12950	COG2814	Major facilitator Superfamily
EML4_RS12955	COG2951	lytic endotransglycosylase activity
EML4_RS12960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EML4_RS12970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EML4_RS12975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EML4_RS12990	COG2816	NAD+ diphosphatase activity
EML4_RS12995	COG1605	Chorismate mutase
EML4_RS12995	COG0077	Prephenate dehydratase
EML4_RS13000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EML4_RS13005	COG3474	cytochrome
EML4_RS13015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4_RS13020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EML4_RS13025	COG1278	Cold shock
EML4_RS13030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4_RS13040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EML4_RS13040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EML4_RS13045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EML4_RS13075	COG2900	Belongs to the SlyX family
EML4_RS13085	COG0484	heat shock protein binding
EML4_RS13090	COG0443	Heat shock 70 kDa protein
EML4_RS13105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EML4_RS13130	COG0295	cytidine deaminase activity
EML4_RS13135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EML4_RS13140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EML4_RS13145	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EML4_RS13155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EML4_RS13160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EML4_RS13165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EML4_RS13175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EML4_RS13180	COG1845	cytochrome c oxidase, subunit III
EML4_RS13185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4_RS13190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EML4_RS13195	COG0477	Major facilitator Superfamily
EML4_RS13200	COG0067	glutamate synthase
EML4_RS13200	COG0069	glutamate synthase activity
EML4_RS13200	COG0070	glutamate synthase
EML4_RS13205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EML4_RS13220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EML4_RS13230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4_RS13260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS13280	COG0848	biopolymer transport protein
EML4_RS13290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4_RS13305	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4_RS13310	COG3454	Phosphonate metabolism
EML4_RS13315	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4_RS13320	COG3639	organic phosphonate transmembrane transporter activity
EML4_RS13325	COG3639	organic phosphonate transmembrane transporter activity
EML4_RS13330	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EML4_RS13335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EML4_RS13345	COG4778	phosphonate C-P lyase system protein PhnL
EML4_RS13350	COG4107	phosphonate C-P lyase system protein PhnK
EML4_RS13355	COG3627	carbon phosphorus lyase activity
EML4_RS13360	COG3626	phosphonate metabolism
EML4_RS13365	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EML4_RS13370	COG3624	Phosphonate C-P lyase system protein PhnG
EML4_RS13375	COG2188	Transcriptional regulator
EML4_RS13380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EML4_RS13385	COG0837	glucose binding
EML4_RS13390	COG1803	Methylglyoxal synthase
EML4_RS13395	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EML4_RS13400	COG4166	transmembrane transport
EML4_RS13405	COG4174	ABC transporter (Permease)
EML4_RS13410	COG4239	(ABC) transporter, permease
EML4_RS13415	COG4172	Belongs to the ABC transporter superfamily
EML4_RS13420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS13425	COG0174	glutamine synthetase
EML4_RS13430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS13435	COG3265	gluconokinase activity
EML4_RS13440	COG1174	glycine betaine transport
EML4_RS13445	COG1125	glycine betaine transport
EML4_RS13450	COG1174	glycine betaine transport
EML4_RS13455	COG1732	Glycine betaine
EML4_RS13465	COG1959	2 iron, 2 sulfur cluster binding
EML4_RS13470	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4_RS13475	COG0501	Belongs to the peptidase M48B family
EML4_RS13480	COG4269	membrane
EML4_RS13495	COG0697	spore germination
EML4_RS13510	COG0791	NLP P60 protein
EML4_RS13520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EML4_RS13525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EML4_RS13560	COG4964	Belongs to the GSP D family
EML4_RS13600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EML4_RS13605	COG3422	double-strand break repair
EML4_RS13610	COG3757	hydrolase, family 25
EML4_RS13615	COG0697	spore germination
EML4_RS13620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4_RS13635	COG0492	ferredoxin-NADP+ reductase activity
EML4_RS13650	COG0481	GTPase activity
EML4_RS13655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EML4_RS13670	COG1396	sequence-specific DNA binding
EML4_RS13685	COG1917	Cupin 2, conserved barrel domain protein
EML4_RS13685	COG2169	Transcriptional regulator
EML4_RS13690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4_RS13715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EML4_RS13720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EML4_RS13725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EML4_RS13735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EML4_RS13740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4_RS13740	COG0072	phenylalanine-tRNA ligase activity
EML4_RS13745	COG0667	Aldo Keto reductase
EML4_RS13765	COG4977	sequence-specific DNA binding
EML4_RS13790	COG1570	exodeoxyribonuclease VII activity
EML4_RS13795	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS13805	COG1846	Transcriptional regulator
EML4_RS13810	COG0697	spore germination
EML4_RS13815	COG2309	aminopeptidase activity
EML4_RS13825	COG1393	Belongs to the ArsC family
EML4_RS13845	COG1309	transcriptional regulator
EML4_RS13855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EML4_RS13855	COG0519	Catalyzes the synthesis of GMP from XMP
EML4_RS13870	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EML4_RS13900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EML4_RS13910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EML4_RS13920	COG1968	undecaprenyl-diphosphatase activity
EML4_RS13935	COG0284	orotidine-5'-phosphate decarboxylase activity
EML4_RS13945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EML4_RS13955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EML4_RS13960	COG0792	nuclease activity
EML4_RS13975	COG1175	transmembrane transport
EML4_RS13980	COG0395	ABC-type sugar transport system, permease component
EML4_RS13985	COG3842	ATPase activity
EML4_RS13995	COG0189	ligase activity
EML4_RS14000	COG0606	chelatase, subunit chli
EML4_RS14005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EML4_RS14010	COG1280	lysine exporter protein (LysE YggA)
EML4_RS14015	COG0756	dUTP diphosphatase activity
EML4_RS14020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EML4_RS14025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EML4_RS14040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EML4_RS14045	COG2226	methyltransferase
EML4_RS14050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EML4_RS14055	COG1024	Enoyl-CoA hydratase
EML4_RS14060	COG0268	Binds directly to 16S ribosomal RNA
EML4_RS14190	COG3727	T/G mismatch-specific endonuclease activity
EML4_RS14210	COG4372	Transposase
EML4_RS14245	COG3501	Rhs element vgr protein
EML4_RS14255	COG3422	double-strand break repair
EML4_RS14280	COG1309	transcriptional regulator
EML4_RS14300	COG1566	PFAM secretion protein HlyD family protein
EML4_RS14315	COG0668	transmembrane transport
EML4_RS14360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EML4_RS14365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EML4_RS14370	COG1454	alcohol dehydrogenase
EML4_RS14375	COG0747	negative chemotaxis
EML4_RS14380	COG0601	transmembrane transport
EML4_RS14390	COG4608	Belongs to the ABC transporter superfamily
EML4_RS14395	COG1349	DNA-binding transcription factor activity
EML4_RS14400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4_RS14425	COG4302	ethanolamine ammonia-lyase activity
EML4_RS14430	COG0025	NhaP-type Na H and K H
EML4_RS14435	COG4106	trans-aconitate 2-methyltransferase activity
EML4_RS14450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS14455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS14465	COG0747	negative chemotaxis
EML4_RS14485	COG4172	Belongs to the ABC transporter superfamily
EML4_RS14495	COG3706	GGDEF domain
EML4_RS14520	COG0596	Alpha beta hydrolase
EML4_RS14525	COG0745	RESPONSE REGULATOR receiver
EML4_RS14535	COG1764	response to oxidative stress
EML4_RS14545	COG0596	Alpha beta hydrolase
EML4_RS14565	COG0783	Belongs to the Dps family
EML4_RS14570	COG0243	molybdopterin cofactor binding
EML4_RS14580	COG4566	intracellular signal transduction
EML4_RS14585	COG4566	intracellular signal transduction
EML4_RS14615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS14625	COG1414	Transcriptional regulator
EML4_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS14660	COG1522	sequence-specific DNA binding
EML4_RS14665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4_RS14675	COG0702	epimerase
EML4_RS14685	COG2233	PERMEase
EML4_RS14740	COG0395	ABC-type sugar transport system, permease component
EML4_RS14745	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4_RS14755	COG3842	ATPase activity
EML4_RS14795	COG1653	transport
EML4_RS14805	COG0395	ABC-type sugar transport system, permease component
EML4_RS14810	COG3842	ATPase activity
EML4_RS14820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS14825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS14830	COG1116	anion transmembrane transporter activity
EML4_RS14835	COG0395	ABC-type sugar transport system, permease component
EML4_RS14840	COG1175	transmembrane transport
EML4_RS14870	COG1609	Transcriptional regulator
EML4_RS14885	COG1082	Xylose isomerase domain protein TIM barrel
EML4_RS14900	COG3842	ATPase activity
EML4_RS14905	COG0395	ABC-type sugar transport system, permease component
EML4_RS14910	COG1175	transmembrane transport
EML4_RS14915	COG1653	transport
EML4_RS14920	COG1309	transcriptional regulator
EML4_RS14925	COG0673	inositol 2-dehydrogenase activity
EML4_RS14940	COG0673	inositol 2-dehydrogenase activity
EML4_RS14950	COG1278	Cold shock
EML4_RS14960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4_RS14985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4_RS14990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EML4_RS15005	COG3842	ATPase activity
EML4_RS15010	COG0395	ABC-type sugar transport system, permease component
EML4_RS15015	COG1175	transmembrane transport
EML4_RS15035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS15040	COG3618	amidohydrolase
EML4_RS15045	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS15050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS15060	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EML4_RS15065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS15070	COG2186	Transcriptional regulator
EML4_RS15085	COG0667	Aldo Keto reductase
EML4_RS15115	COG4977	sequence-specific DNA binding
EML4_RS15120	COG2223	nitrite transmembrane transporter activity
EML4_RS15125	COG0583	DNA-binding transcription factor activity
EML4_RS15130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4_RS15140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS15145	COG2084	Dehydrogenase
EML4_RS15160	COG1609	Transcriptional regulator
EML4_RS15165	COG1063	alcohol dehydrogenase
EML4_RS15170	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS15180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS15185	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
EML4_RS15190	COG1175	transmembrane transport
EML4_RS15195	COG0395	ABC-type sugar transport system, permease component
EML4_RS15210	COG0395	ABC-type sugar transport system, permease component
EML4_RS15215	COG1175	transmembrane transport
EML4_RS15220	COG2182	Extracellular solute-binding protein
EML4_RS15225	COG0626	cystathionine gamma-synthase activity
EML4_RS15240	COG0803	Belongs to the bacterial solute-binding protein 9 family
EML4_RS15250	COG1121	(ABC) transporter
EML4_RS15255	COG0523	cobalamin synthesis protein
EML4_RS15270	COG0523	cobalamin synthesis protein
EML4_RS15275	COG1653	transport
EML4_RS15280	COG1175	transmembrane transport
EML4_RS15285	COG0395	ABC-type sugar transport system, permease component
EML4_RS15290	COG3842	ATPase activity
EML4_RS15300	COG3047	cAMP biosynthetic process
EML4_RS15325	COG0583	DNA-binding transcription factor activity
EML4_RS15330	COG1879	ABC-type sugar transport system periplasmic component
EML4_RS15335	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS15340	COG1129	ABC transporter
EML4_RS15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4_RS15355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS15365	COG3257	ureidoglycine aminohydrolase activity
EML4_RS15375	COG5001	Diguanylate cyclase
EML4_RS15380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4_RS15390	COG0747	negative chemotaxis
EML4_RS15395	COG0601	transmembrane transport
EML4_RS15400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS15410	COG4608	Belongs to the ABC transporter superfamily
EML4_RS15415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EML4_RS15430	COG0346	lactoylglutathione lyase activity
EML4_RS15440	COG0129	dihydroxy-acid dehydratase activity
EML4_RS15445	COG1879	ABC-type sugar transport system periplasmic component
EML4_RS15450	COG1129	ABC transporter
EML4_RS15455	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS15460	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS15465	COG2186	Transcriptional regulator
EML4_RS15480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4_RS15485	COG0587	DNA-directed DNA polymerase activity
EML4_RS15515	COG0673	inositol 2-dehydrogenase activity
EML4_RS15525	COG3842	ATPase activity
EML4_RS15530	COG0395	ABC-type sugar transport system, permease component
EML4_RS15535	COG1175	transmembrane transport
EML4_RS15540	COG1653	transport
EML4_RS15550	COG0673	inositol 2-dehydrogenase activity
EML4_RS15565	COG5001	Diguanylate cyclase
EML4_RS15580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EML4_RS15585	COG2894	cell division
EML4_RS15590	COG0850	regulation of cytokinetic process
EML4_RS15595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4_RS15600	COG2186	Transcriptional regulator
EML4_RS15605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS15615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4_RS15620	COG1063	alcohol dehydrogenase
EML4_RS15625	COG1312	Catalyzes the dehydration of D-mannonate
EML4_RS15645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4_RS15650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4_RS15655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS15670	COG0625	glutathione transferase activity
EML4_RS15675	COG4172	Belongs to the ABC transporter superfamily
EML4_RS15680	COG1921	L-seryl-tRNASec selenium transferase activity
EML4_RS15695	COG3964	amidohydrolase
EML4_RS15705	COG0601	transmembrane transport
EML4_RS15710	COG0747	negative chemotaxis
EML4_RS15715	COG0438	transferase activity, transferring glycosyl groups
EML4_RS15755	COG4989	oxidoreductase activity
EML4_RS15765	COG2188	Transcriptional regulator
EML4_RS15775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EML4_RS15790	COG3842	ATPase activity
EML4_RS15795	COG1653	transport
EML4_RS15800	COG1175	transmembrane transport
EML4_RS15805	COG0395	ABC-type sugar transport system, permease component
EML4_RS15810	COG1501	Belongs to the glycosyl hydrolase 31 family
EML4_RS15820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS15825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS15830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EML4_RS15835	COG0352	thiamine-phosphate diphosphorylase activity
EML4_RS15840	COG0351	phosphomethylpyrimidine kinase
EML4_RS15845	COG1522	sequence-specific DNA binding
EML4_RS15850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EML4_RS15855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS15870	COG2204	response regulator
EML4_RS15875	COG4191	Histidine kinase
EML4_RS15880	COG1301	dicarboxylic acid transport
EML4_RS15885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS15900	COG1473	amidohydrolase
EML4_RS15920	COG1215	transferase activity, transferring glycosyl groups
EML4_RS15930	COG2942	2-epimerase
EML4_RS15955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS15965	COG2197	response regulator
EML4_RS15995	COG3307	-O-antigen
EML4_RS16000	COG1596	polysaccharide export
EML4_RS16005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EML4_RS16020	COG0840	transmembrane signaling receptor activity
EML4_RS16025	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS16035	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS16045	COG2094	Belongs to the DNA glycosylase MPG family
EML4_RS16060	COG1609	Transcriptional regulator
EML4_RS16065	COG1653	transport
EML4_RS16080	COG3842	ATPase activity
EML4_RS16090	COG0673	inositol 2-dehydrogenase activity
EML4_RS16095	COG0602	queuosine metabolic process
EML4_RS16100	COG0720	synthase
EML4_RS16105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EML4_RS16115	COG0673	inositol 2-dehydrogenase activity
EML4_RS16130	COG0395	ABC-type sugar transport system, permease component
EML4_RS16135	COG1175	transmembrane transport
EML4_RS16160	COG0583	DNA-binding transcription factor activity
EML4_RS16165	COG0281	malic enzyme
EML4_RS16165	COG0280	phosphate acetyltransferase
EML4_RS16180	COG0765	amino acid transport
EML4_RS16185	COG1126	abc transporter atp-binding protein
EML4_RS16190	COG2079	MmgE PrpD family protein
EML4_RS16195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS16220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EML4_RS16230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4_RS16235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EML4_RS16240	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS16245	COG1129	ABC transporter
EML4_RS16260	COG1473	amidohydrolase
EML4_RS16265	COG0747	negative chemotaxis
EML4_RS16285	COG0601	transmembrane transport
EML4_RS16290	COG0583	DNA-binding transcription factor activity
EML4_RS16295	COG1446	asparaginase
EML4_RS16310	COG0747	negative chemotaxis
EML4_RS16330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS16335	COG0601	transmembrane transport
EML4_RS16340	COG2197	response regulator
EML4_RS16345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4_RS16350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS16360	COG3842	ATPase activity
EML4_RS16365	COG0395	ABC-type sugar transport system, permease component
EML4_RS16370	COG1175	transmembrane transport
EML4_RS16380	COG0673	inositol 2-dehydrogenase activity
EML4_RS16385	COG0673	inositol 2-dehydrogenase activity
EML4_RS16405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS16410	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EML4_RS16430	COG1595	DNA-templated transcription, initiation
EML4_RS16435	COG1120	ATPase activity
EML4_RS16440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS16455	COG2226	methyltransferase
EML4_RS16465	COG1120	ATPase activity
EML4_RS16470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS16515	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS16520	COG0473	3-isopropylmalate dehydrogenase activity
EML4_RS16525	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS16530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS16570	COG4172	Belongs to the ABC transporter superfamily
EML4_RS16575	COG1522	sequence-specific DNA binding
EML4_RS16600	COG0583	DNA-binding transcription factor activity
EML4_RS16615	COG1126	abc transporter atp-binding protein
EML4_RS16625	COG1473	amidohydrolase
EML4_RS16630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16640	COG1959	2 iron, 2 sulfur cluster binding
EML4_RS16650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4_RS16655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16685	COG1960	acyl-CoA dehydrogenase activity
EML4_RS16695	COG0747	negative chemotaxis
EML4_RS16710	COG0444	Belongs to the ABC transporter superfamily
EML4_RS16720	COG0667	Aldo Keto reductase
EML4_RS16730	COG0583	DNA-binding transcription factor activity
EML4_RS16735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16740	COG4166	transmembrane transport
EML4_RS16755	COG0747	negative chemotaxis
EML4_RS16760	COG1473	amidohydrolase
EML4_RS16765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS16805	COG4608	Belongs to the ABC transporter superfamily
EML4_RS16810	COG0444	Belongs to the ABC transporter superfamily
EML4_RS16820	COG0601	transmembrane transport
EML4_RS16830	COG2186	Transcriptional regulator
EML4_RS16845	COG0300	oxidoreductase activity
EML4_RS16855	COG3453	Protein conserved in bacteria
EML4_RS16855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4_RS16860	COG0640	Transcriptional regulator
EML4_RS16870	COG2391	methyltransferase activity
EML4_RS16875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EML4_RS16885	COG0022	dehydrogenase e1 component
EML4_RS16895	COG1960	acyl-CoA dehydrogenase activity
EML4_RS16900	COG0183	Belongs to the thiolase family
EML4_RS16910	COG1960	acyl-CoA dehydrogenase activity
EML4_RS16915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EML4_RS16935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EML4_RS16940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EML4_RS16945	COG4952	isomerase
EML4_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS16950	COG3347	Dehydrogenase
EML4_RS16955	COG1349	DNA-binding transcription factor activity
EML4_RS16965	COG1129	ABC transporter
EML4_RS16970	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS16975	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS16980	COG3254	rhamnose metabolic process
EML4_RS16995	COG2264	protein methyltransferase activity
EML4_RS17000	COG5001	Diguanylate cyclase
EML4_RS17015	COG4335	DNA alkylation repair
EML4_RS17020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EML4_RS17025	COG4208	sulfate ABC transporter
EML4_RS17035	COG4150	thiosulfate binding
EML4_RS17040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EML4_RS17055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4_RS17065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EML4_RS17075	COG1040	competence protein
EML4_RS17080	COG2226	methyltransferase
EML4_RS17095	COG0494	nUDIX hydrolase
EML4_RS17105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EML4_RS17110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EML4_RS17115	COG0653	protein targeting
EML4_RS17120	COG0697	spore germination
EML4_RS17185	COG2244	polysaccharide biosynthetic process
EML4_RS17200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EML4_RS17210	COG0489	protein tyrosine kinase activity
EML4_RS17210	COG3206	protein involved in exopolysaccharide biosynthesis
EML4_RS17230	COG0438	transferase activity, transferring glycosyl groups
EML4_RS17235	COG0438	transferase activity, transferring glycosyl groups
EML4_RS17250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EML4_RS17255	COG2273	Hydrolase Family 16
EML4_RS17255	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EML4_RS17270	COG3842	ATPase activity
EML4_RS17275	COG3833	ABC-type maltose transport systems, permease component
EML4_RS17330	COG1396	sequence-specific DNA binding
EML4_RS17340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EML4_RS17345	COG1129	ABC transporter
EML4_RS17350	COG4214	carbohydrate transport
EML4_RS17355	COG4213	ABC transporter substrate-binding protein
EML4_RS17370	COG0346	lactoylglutathione lyase activity
EML4_RS17375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EML4_RS17375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EML4_RS17380	COG4770	biotin carboxylase activity
EML4_RS17395	COG0625	glutathione transferase activity
EML4_RS17400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EML4_RS17405	COG3800	Transcriptional regulator
EML4_RS17405	COG1396	sequence-specific DNA binding
EML4_RS17415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EML4_RS17425	COG0300	oxidoreductase activity
EML4_RS17435	COG2096	Adenosyltransferase
EML4_RS17445	COG2086	electron transfer activity
EML4_RS17455	COG1250	3-hydroxyacyl-CoA dehydrogenase
EML4_RS17465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EML4_RS17470	COG0165	Argininosuccinate lyase
EML4_RS17505	COG2884	Cell division ATP-binding protein ftsE
EML4_RS17525	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EML4_RS17535	COG0287	Prephenate dehydrogenase
EML4_RS17540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EML4_RS17545	COG2226	methyltransferase
EML4_RS17550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4_RS17570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EML4_RS17575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EML4_RS17615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EML4_RS17620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EML4_RS17630	COG4974	Belongs to the 'phage' integrase family
EML4_RS17635	COG0825	malonyl-CoA metabolic process
EML4_RS17640	COG3034	peptidoglycan biosynthetic process
EML4_RS17645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EML4_RS17645	COG0425	Belongs to the sulfur carrier protein TusA family
EML4_RS17650	COG0523	cobalamin synthesis protein
EML4_RS17655	COG1686	Belongs to the peptidase S11 family
EML4_RS17660	COG1473	amidohydrolase
EML4_RS17670	COG4953	penicillin-binding protein 1C
EML4_RS17675	COG2373	Large extracellular alpha-helical protein
EML4_RS17680	COG2835	tetraacyldisaccharide 4'-kinase activity
EML4_RS17715	COG0482	sulfurtransferase activity
EML4_RS17730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4_RS17745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EML4_RS17750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EML4_RS17755	COG0037	tRNA processing
EML4_RS17765	COG2885	chlorophyll binding
EML4_RS17770	COG0823	Involved in the tonB-independent uptake of proteins
EML4_RS17790	COG0824	Thioesterase
EML4_RS17800	COG0494	nUDIX hydrolase
EML4_RS17815	COG2255	four-way junction helicase activity
EML4_RS17820	COG0632	four-way junction helicase activity
EML4_RS17825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EML4_RS17830	COG0840	transmembrane signaling receptor activity
EML4_RS17835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS17840	COG0217	transcriptional regulatory protein
EML4_RS17855	COG1692	metallophosphoesterase
EML4_RS17865	COG1253	flavin adenine dinucleotide binding
EML4_RS17900	COG3263	regulation of cellular component size
EML4_RS17905	COG0126	phosphoglycerate kinase activity
EML4_RS17910	COG3588	fructose-bisphosphate aldolase
EML4_RS17935	COG0254	rRNA binding
EML4_RS17940	COG1132	(ABC) transporter
EML4_RS17960	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS17995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EML4_RS18000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EML4_RS18005	COG0457	Tetratricopeptide repeat
EML4_RS18010	COG3750	Belongs to the UPF0335 family
EML4_RS18030	COG0469	pyruvate kinase activity
EML4_RS18035	COG3108	Peptidase M15
EML4_RS18040	COG2204	response regulator
EML4_RS18045	COG1164	Oligoendopeptidase f
EML4_RS18050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4_RS18060	COG5310	Homospermidine synthase
EML4_RS18070	COG0737	Belongs to the 5'-nucleotidase family
EML4_RS18075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EML4_RS18080	COG0330	HflC and HflK could
EML4_RS18110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EML4_RS18115	COG2951	lytic endotransglycosylase activity
EML4_RS18130	COG2205	protein histidine kinase activity
EML4_RS18145	COG0067	glutamate synthase
EML4_RS18145	COG0069	glutamate synthase activity
EML4_RS18145	COG0070	glutamate synthase
EML4_RS18160	COG2205	protein histidine kinase activity
EML4_RS18165	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EML4_RS18170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EML4_RS18180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EML4_RS18190	COG0252	asparaginase activity
EML4_RS18200	COG1027	Aspartate ammonia-lyase
EML4_RS18205	COG2186	Transcriptional regulator
EML4_RS18225	COG1309	transcriptional regulator
EML4_RS18245	COG4176	ABC-type proline glycine betaine transport system permease component
EML4_RS18250	COG0517	IMP dehydrogenase activity
EML4_RS18250	COG4175	Glycine betaine
EML4_RS18255	COG2986	histidine ammonia-lyase
EML4_RS18270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS18275	COG4172	Belongs to the ABC transporter superfamily
EML4_RS18285	COG0601	transmembrane transport
EML4_RS18290	COG0747	negative chemotaxis
EML4_RS18300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EML4_RS18305	COG1454	alcohol dehydrogenase
EML4_RS18345	COG2307	Protein conserved in bacteria
EML4_RS18345	COG2308	Evidence 4 Homologs of previously reported genes of
EML4_RS18360	COG0488	(ABC) transporter
EML4_RS18365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4_RS18370	COG2186	Transcriptional regulator
EML4_RS18385	COG1175	transmembrane transport
EML4_RS18390	COG0395	ABC-type sugar transport system, permease component
EML4_RS18400	COG3842	ATPase activity
EML4_RS18425	COG1304	FMN binding
EML4_RS18440	COG1063	alcohol dehydrogenase
EML4_RS18445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4_RS18450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS18460	COG0765	amino acid transport
EML4_RS18465	COG0765	amino acid transport
EML4_RS18470	COG4221	oxidoreductase activity
EML4_RS18475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4_RS18480	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS18485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS18500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4_RS18515	COG0697	spore germination
EML4_RS18520	COG0697	spore germination
EML4_RS18525	COG0511	ligase activity, forming carbon-carbon bonds
EML4_RS18530	COG0439	Biotin carboxylase
EML4_RS18540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EML4_RS18545	COG1984	allophanate hydrolase subunit 2
EML4_RS18550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EML4_RS18555	COG3842	ATPase activity
EML4_RS18565	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EML4_RS18575	COG0436	Aminotransferase
EML4_RS18590	COG0840	transmembrane signaling receptor activity
EML4_RS18595	COG1070	Carbohydrate kinase
EML4_RS18600	COG1830	Aldolase
EML4_RS18605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EML4_RS18610	COG0667	Aldo Keto reductase
EML4_RS18620	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS18625	COG1129	ABC transporter
EML4_RS18665	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4_RS18680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EML4_RS18695	COG0395	ABC-type sugar transport system, permease component
EML4_RS18710	COG3842	ATPase activity
EML4_RS18725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EML4_RS18725	COG1648	precorrin-2 dehydrogenase activity
EML4_RS18730	COG0243	molybdopterin cofactor binding
EML4_RS18740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EML4_RS18745	COG1116	anion transmembrane transporter activity
EML4_RS18750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS18755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS18765	COG3707	response regulator
EML4_RS18770	COG1802	Transcriptional regulator
EML4_RS18775	COG1914	H( )-stimulated, divalent metal cation uptake system
EML4_RS18780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EML4_RS18785	COG4336	lyase activity
EML4_RS18790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EML4_RS18795	COG4770	biotin carboxylase activity
EML4_RS18800	COG0366	Alpha amylase catalytic
EML4_RS18810	COG4771	TonB-dependent receptor
EML4_RS18815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EML4_RS18835	COG1414	Transcriptional regulator
EML4_RS18840	COG1475	DNA binding
EML4_RS18845	COG1192	Involved in chromosome partitioning
EML4_RS18875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EML4_RS18885	COG2986	histidine ammonia-lyase
EML4_RS18890	COG1228	amidohydrolase
EML4_RS18895	COG0402	S-adenosylhomocysteine deaminase activity
EML4_RS18935	COG4172	Belongs to the ABC transporter superfamily
EML4_RS18940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS18945	COG0601	transmembrane transport
EML4_RS18950	COG4166	transmembrane transport
EML4_RS18955	COG0395	ABC-type sugar transport system, permease component
EML4_RS18970	COG1566	PFAM secretion protein HlyD family protein
EML4_RS18990	COG2207	Transcriptional regulator
EML4_RS18995	COG1309	transcriptional regulator
EML4_RS19000	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS19025	COG1846	Transcriptional regulator
EML4_RS19030	COG0583	DNA-binding transcription factor activity
EML4_RS19035	COG2828	Protein conserved in bacteria
EML4_RS19050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS19065	COG0840	transmembrane signaling receptor activity
EML4_RS19075	COG0583	DNA-binding transcription factor activity
EML4_RS19080	COG0346	lactoylglutathione lyase activity
EML4_RS19095	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EML4_RS19115	COG0583	DNA-binding transcription factor activity
EML4_RS19120	COG0477	Major facilitator Superfamily
EML4_RS19135	COG0745	RESPONSE REGULATOR receiver
EML4_RS19140	COG0671	phosphoesterase, PA-phosphatase related
EML4_RS19190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EML4_RS19195	COG0156	8-amino-7-oxononanoate synthase activity
EML4_RS19200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EML4_RS19205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4_RS19210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EML4_RS19225	COG0010	Belongs to the arginase family
EML4_RS19235	COG0697	spore germination
EML4_RS19240	COG0673	inositol 2-dehydrogenase activity
EML4_RS19260	COG0477	Major facilitator Superfamily
EML4_RS19265	COG0642	Histidine kinase
EML4_RS19270	COG0745	RESPONSE REGULATOR receiver
EML4_RS19275	COG2194	sulfuric ester hydrolase activity
EML4_RS19285	COG0583	DNA-binding transcription factor activity
EML4_RS19290	COG4774	siderophore transport
EML4_RS19305	COG1120	ATPase activity
EML4_RS19315	COG3474	cytochrome
EML4_RS19320	COG2137	regulation of response to DNA damage stimulus
EML4_RS19325	COG3386	PFAM SMP-30 Gluconolaconase
EML4_RS19335	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS19340	COG1129	ABC transporter
EML4_RS19345	COG1879	ABC-type sugar transport system periplasmic component
EML4_RS19350	COG4585	Histidine kinase
EML4_RS19355	COG2197	response regulator
EML4_RS19365	COG2133	pyrroloquinoline quinone binding
EML4_RS19375	COG0500	methyltransferase
EML4_RS19380	COG0564	pseudouridine synthase activity
EML4_RS19395	COG3448	diguanylate cyclase activity
EML4_RS19395	COG4175	Glycine betaine
EML4_RS19400	COG4176	ABC-type proline glycine betaine transport system permease component
EML4_RS19420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4_RS19425	COG3206	protein involved in exopolysaccharide biosynthesis
EML4_RS19425	COG0489	protein tyrosine kinase activity
EML4_RS19430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EML4_RS19435	COG1215	transferase activity, transferring glycosyl groups
EML4_RS19440	COG1215	transferase activity, transferring glycosyl groups
EML4_RS19445	COG1215	transferase activity, transferring glycosyl groups
EML4_RS19450	COG0438	transferase activity, transferring glycosyl groups
EML4_RS19455	COG2273	Hydrolase Family 16
EML4_RS19460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EML4_RS19465	COG2244	polysaccharide biosynthetic process
EML4_RS19470	COG0463	Glycosyl transferase, family 2
EML4_RS19475	COG2327	Polysaccharide pyruvyl transferase
EML4_RS19480	COG1215	transferase activity, transferring glycosyl groups
EML4_RS19500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4_RS19505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS19520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4_RS19520	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4_RS19540	COG1523	belongs to the glycosyl hydrolase 13 family
EML4_RS19545	COG0033	Phosphoglucomutase
EML4_RS19550	COG0297	glycogen (starch) synthase activity
EML4_RS19555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EML4_RS19560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EML4_RS19565	COG0058	SHG alpha-glucan phosphorylase activity
EML4_RS19575	COG1794	racemase activity, acting on amino acids and derivatives
EML4_RS19580	COG1522	sequence-specific DNA binding
EML4_RS19590	COG2084	Dehydrogenase
EML4_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS19600	COG1063	alcohol dehydrogenase
EML4_RS19610	COG4988	ABC transporter
EML4_RS19615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EML4_RS19625	COG1294	oxidase, subunit
EML4_RS19655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EML4_RS19660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EML4_RS19690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EML4_RS19695	COG0539	negative regulation of cytoplasmic translation
EML4_RS19725	COG4221	oxidoreductase activity
EML4_RS19735	COG0747	negative chemotaxis
EML4_RS19740	COG0601	transmembrane transport
EML4_RS19745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS19750	COG0444	Belongs to the ABC transporter superfamily
EML4_RS19755	COG4608	Belongs to the ABC transporter superfamily
EML4_RS19760	COG0246	Mannitol dehydrogenase
EML4_RS19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS19820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EML4_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS19840	COG4993	Dehydrogenase
EML4_RS19845	COG3685	Protein conserved in bacteria
EML4_RS19875	COG0693	protein deglycase activity
EML4_RS19895	COG0189	ligase activity
EML4_RS19900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4_RS19905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EML4_RS19920	COG0435	Glutathione S-transferase
EML4_RS19925	COG0583	DNA-binding transcription factor activity
EML4_RS19930	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS19935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS19940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS19945	COG1116	anion transmembrane transporter activity
EML4_RS19955	COG1522	sequence-specific DNA binding
EML4_RS19970	COG0784	Response regulator, receiver
EML4_RS19980	COG3920	Histidine kinase
EML4_RS19990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EML4_RS20005	COG0019	diaminopimelate decarboxylase activity
EML4_RS20020	COG0527	aspartate kinase activity
EML4_RS20030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EML4_RS20035	COG2890	protein-(glutamine-N5) methyltransferase activity
EML4_RS20045	COG0542	response to heat
EML4_RS20050	COG0741	lytic transglycosylase activity
EML4_RS20050	COG1196	nuclear chromosome segregation
EML4_RS20050	COG0739	heme binding
EML4_RS20090	COG3609	addiction module antidote protein, CC2985 family
EML4_RS20120	COG2376	Dihydroxyacetone kinase
EML4_RS20125	COG1522	sequence-specific DNA binding
EML4_RS20145	COG0431	NADPH-dependent FMN reductase
EML4_RS20155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS20165	COG4172	Belongs to the ABC transporter superfamily
EML4_RS20170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS20190	COG0277	FAD linked oxidase domain protein
EML4_RS20210	COG0778	Nitroreductase
EML4_RS20240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4_RS20265	COG2318	DinB family
EML4_RS20270	COG0583	DNA-binding transcription factor activity
EML4_RS20285	COG1335	isochorismatase
EML4_RS20310	COG3842	ATPase activity
EML4_RS20315	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4_RS20320	COG1177	transmembrane transport
EML4_RS20325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EML4_RS20335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EML4_RS20350	COG1120	ATPase activity
EML4_RS20355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS20360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS20365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EML4_RS20370	COG1629	transport
EML4_RS20370	COG4774	siderophore transport
EML4_RS20375	COG4702	Belongs to the UPF0303 family
EML4_RS20395	COG1024	Enoyl-CoA hydratase
EML4_RS20400	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS20405	COG1653	transport
EML4_RS20410	COG1175	transmembrane transport
EML4_RS20415	COG0395	ABC-type sugar transport system, permease component
EML4_RS20420	COG3842	ATPase activity
EML4_RS20445	COG3474	cytochrome
EML4_RS20450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EML4_RS20455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4_RS20460	COG1845	cytochrome c oxidase, subunit III
EML4_RS20475	COG0047	phosphoribosylformylglycinamidine synthase activity
EML4_RS20490	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4_RS20490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4_RS20500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EML4_RS20520	COG1309	transcriptional regulator
EML4_RS20535	COG1136	(ABC) transporter
EML4_RS20550	COG1063	alcohol dehydrogenase
EML4_RS20560	COG1879	ABC-type sugar transport system periplasmic component
EML4_RS20570	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS20590	COG0477	Major facilitator Superfamily
EML4_RS20695	COG3501	Rhs element vgr protein
EML4_RS20715	COG5001	Diguanylate cyclase
EML4_RS20715	COG3300	MHYT domain
EML4_RS20740	COG1253	flavin adenine dinucleotide binding
EML4_RS20755	COG3842	ATPase activity
EML4_RS20760	COG0395	ABC-type sugar transport system, permease component
EML4_RS20765	COG1175	transmembrane transport
EML4_RS20770	COG1653	transport
EML4_RS20780	COG0673	inositol 2-dehydrogenase activity
EML4_RS20785	COG1609	Transcriptional regulator
EML4_RS20800	COG0583	DNA-binding transcription factor activity
EML4_RS20810	COG3547	Transposase (IS116 IS110 IS902 family)
EML4_RS20815	COG1879	ABC-type sugar transport system periplasmic component
EML4_RS20820	COG1129	ABC transporter
EML4_RS20825	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS20830	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS20835	COG1609	Transcriptional regulator
EML4_RS20845	COG0673	inositol 2-dehydrogenase activity
EML4_RS20905	COG0714	Associated with various cellular activities
EML4_RS20910	COG3256	nitric oxide reductase
EML4_RS20925	COG1845	cytochrome c oxidase, subunit III
EML4_RS20940	COG0163	prenyltransferase activity
EML4_RS20945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EML4_RS20950	COG3189	MarR family transcriptional regulator
EML4_RS20960	COG0826	peptidase U32
EML4_RS20985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EML4_RS20995	COG4459	periplasmic nitrate reductase
EML4_RS21010	COG0243	molybdopterin cofactor binding
EML4_RS21020	COG3005	denitrification pathway
EML4_RS21035	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS21040	COG1535	isochorismatase
EML4_RS21040	COG3433	isochorismatase activity
EML4_RS21045	COG1021	2,3-dihydroxybenzoate-AMP ligase
EML4_RS21050	COG1169	isochorismate synthase
EML4_RS21060	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EML4_RS21060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EML4_RS21065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EML4_RS21075	COG2375	cellular response to nickel ion
EML4_RS21085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS21090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS21100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS21110	COG4774	siderophore transport
EML4_RS21110	COG1629	transport
EML4_RS21115	COG1960	acyl-CoA dehydrogenase activity
EML4_RS21120	COG0583	DNA-binding transcription factor activity
EML4_RS21125	COG1609	Transcriptional regulator
EML4_RS21135	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4_RS21145	COG3842	ATPase activity
EML4_RS21155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EML4_RS21160	COG0583	DNA-binding transcription factor activity
EML4_RS21165	COG2814	Major facilitator Superfamily
EML4_RS21170	COG1473	amidohydrolase
EML4_RS21185	COG0747	negative chemotaxis
EML4_RS21190	COG0601	transmembrane transport
EML4_RS21200	COG0444	Belongs to the ABC transporter superfamily
EML4_RS21205	COG4608	Belongs to the ABC transporter superfamily
EML4_RS21210	COG0583	DNA-binding transcription factor activity
EML4_RS21215	COG0747	negative chemotaxis
EML4_RS21225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS21230	COG0154	amidase activity
EML4_RS21235	COG0693	protein deglycase activity
EML4_RS21245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS21250	COG0601	transmembrane transport
EML4_RS21260	COG1473	amidohydrolase
EML4_RS21265	COG4172	Belongs to the ABC transporter superfamily
EML4_RS21270	COG2390	Transcriptional regulator
EML4_RS21280	COG1175	transmembrane transport
EML4_RS21285	COG0395	ABC-type sugar transport system, permease component
EML4_RS21310	COG1069	ribulokinase activity
EML4_RS21335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4_RS21350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EML4_RS21355	COG1414	Transcriptional regulator
EML4_RS21360	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS21370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4_RS21375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4_RS21380	COG1121	(ABC) transporter
EML4_RS21385	COG0803	Belongs to the bacterial solute-binding protein 9 family
EML4_RS21395	COG1752	Esterase of the alpha-beta hydrolase superfamily
EML4_RS21400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EML4_RS21405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EML4_RS21410	COG3273	potassium ion transport
EML4_RS21410	COG0471	metal ion transport
EML4_RS21415	COG1253	flavin adenine dinucleotide binding
EML4_RS21420	COG1309	transcriptional regulator
EML4_RS21440	COG1609	Transcriptional regulator
EML4_RS21445	COG1070	Carbohydrate kinase
EML4_RS21450	COG2115	Belongs to the xylose isomerase family
EML4_RS21460	COG0778	Nitroreductase
EML4_RS21465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EML4_RS21470	COG2011	ABC-type metal ion transport system permease component
EML4_RS21480	COG3300	MHYT domain
EML4_RS21480	COG5001	Diguanylate cyclase
EML4_RS21495	COG2954	triphosphatase activity
EML4_RS21500	COG0800	Aldolase
EML4_RS21520	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EML4_RS21550	COG0523	cobalamin synthesis protein
EML4_RS21560	COG1846	Transcriptional regulator
EML4_RS21565	COG1609	Transcriptional regulator
EML4_RS21570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4_RS21580	COG3718	enzyme involved in inositol metabolism
EML4_RS21590	COG3962	Belongs to the TPP enzyme family
EML4_RS21595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS21610	COG0411	ABC transporter
EML4_RS21625	COG0683	leucine binding
EML4_RS21640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS21650	COG0747	negative chemotaxis
EML4_RS21680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EML4_RS21685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EML4_RS21690	COG1126	abc transporter atp-binding protein
EML4_RS21695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS21700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS21705	COG0765	amino acid transport
EML4_RS21710	COG0765	amino acid transport
EML4_RS21715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EML4_RS21720	COG3485	protocatechuate 3,4-dioxygenase
EML4_RS21725	COG3485	protocatechuate 3,4-dioxygenase
EML4_RS21730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EML4_RS21740	COG0583	DNA-binding transcription factor activity
EML4_RS21755	COG1414	Transcriptional regulator
EML4_RS21765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EML4_RS21770	COG0183	Belongs to the thiolase family
EML4_RS21775	COG1609	Transcriptional regulator
EML4_RS21795	COG0673	inositol 2-dehydrogenase activity
EML4_RS21805	COG1609	Transcriptional regulator
EML4_RS21810	COG0395	ABC-type sugar transport system, permease component
EML4_RS21815	COG1175	transmembrane transport
EML4_RS21830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EML4_RS21850	COG2814	Major facilitator Superfamily
EML4_RS21855	COG4774	siderophore transport
EML4_RS21860	COG3712	iron ion homeostasis
EML4_RS21870	COG1940	carbohydrate kinase activity
EML4_RS21875	COG0584	glycerophosphoryl diester phosphodiesterase
EML4_RS21880	COG0300	oxidoreductase activity
EML4_RS21905	COG3842	ATPase activity
EML4_RS21925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EML4_RS21985	COG0385	Bile acid
EML4_RS21990	COG0667	Aldo Keto reductase
EML4_RS21995	COG0583	DNA-binding transcription factor activity
EML4_RS22025	COG1132	(ABC) transporter
EML4_RS22040	COG3436	PFAM IS66 Orf2 family protein
EML4_RS22045	COG4372	Transposase
EML4_RS22070	COG2226	methyltransferase
EML4_RS22085	COG3436	PFAM IS66 Orf2 family protein
EML4_RS22090	COG4372	Transposase
EML4_RS22105	COG3754	Rhamnan synthesis protein F
EML4_RS22110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4_RS22130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EML4_RS22135	COG1091	dTDP-4-dehydrorhamnose reductase activity
EML4_RS22140	COG1088	dTDP-glucose 4,6-dehydratase activity
EML4_RS22145	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EML4_RS22160	COG1609	Transcriptional regulator
EML4_RS22165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4_RS22165	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4_RS22180	COG0395	ABC-type sugar transport system, permease component
EML4_RS22185	COG3842	ATPase activity
EML4_RS22205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS22210	COG0601	transmembrane transport
EML4_RS22215	COG2186	Transcriptional regulator
EML4_RS22235	COG5001	Diguanylate cyclase
EML4_RS22235	COG3300	MHYT domain
EML4_RS22240	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS22250	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EML4_RS22260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EML4_RS22265	COG0306	phosphate transporter
EML4_RS22270	COG1392	Phosphate transport regulator
EML4_RS22290	COG0745	RESPONSE REGULATOR receiver
EML4_RS22295	COG2205	protein histidine kinase activity
EML4_RS22310	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EML4_RS22325	COG4774	siderophore transport
EML4_RS22335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS22340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4_RS22345	COG1120	ATPase activity
EML4_RS22350	COG0583	DNA-binding transcription factor activity
EML4_RS22360	COG3119	arylsulfatase activity
EML4_RS22365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4_RS22370	COG3842	ATPase activity
EML4_RS22375	COG0165	Argininosuccinate lyase
EML4_RS22380	COG0395	ABC-type sugar transport system, permease component
EML4_RS22385	COG1175	transmembrane transport
EML4_RS22390	COG2182	Extracellular solute-binding protein
EML4_RS22395	COG1940	carbohydrate kinase activity
EML4_RS22420	COG1486	melibiose metabolic process
EML4_RS22425	COG0747	negative chemotaxis
EML4_RS22430	COG0601	transmembrane transport
EML4_RS22435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS22440	COG4172	Belongs to the ABC transporter superfamily
EML4_RS22445	COG1486	melibiose metabolic process
EML4_RS22450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS22455	COG1129	ABC transporter
EML4_RS22455	COG0842	Transport permease protein
EML4_RS22460	COG0842	Transport permease protein
EML4_RS22475	COG0784	Response regulator, receiver
EML4_RS22480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EML4_RS22490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS22495	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4_RS22515	COG0765	amino acid transport
EML4_RS22525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS22535	COG3938	Belongs to the proline racemase family
EML4_RS22550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS22560	COG0765	amino acid transport
EML4_RS22570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4_RS22595	COG3383	formate dehydrogenase (NAD+) activity
EML4_RS22605	COG2223	nitrite transmembrane transporter activity
EML4_RS22610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS22620	COG2186	Transcriptional regulator
EML4_RS22625	COG0747	negative chemotaxis
EML4_RS22630	COG0601	transmembrane transport
EML4_RS22635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS22640	COG4172	Belongs to the ABC transporter superfamily
EML4_RS22645	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS22655	COG2186	Transcriptional regulator
EML4_RS22660	COG0747	negative chemotaxis
EML4_RS22665	COG0601	transmembrane transport
EML4_RS22675	COG0405	Gamma-glutamyltransferase
EML4_RS22685	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS22695	COG3842	ATPase activity
EML4_RS22720	COG3237	CsbD-like
EML4_RS22730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EML4_RS22735	COG3181	Tripartite tricarboxylate transporter family receptor
EML4_RS22740	COG1132	(ABC) transporter
EML4_RS22745	COG0488	(ABC) transporter
EML4_RS22770	COG1049	propionate catabolic process, 2-methylcitrate cycle
EML4_RS22775	COG0110	maltose O-acetyltransferase activity
EML4_RS22785	COG1063	alcohol dehydrogenase
EML4_RS22790	COG3284	Transcriptional regulator
EML4_RS22810	COG1129	ABC transporter
EML4_RS22815	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS22820	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS22830	COG0572	uridine kinase
EML4_RS22835	COG1082	Xylose isomerase domain protein TIM barrel
EML4_RS22845	COG1126	abc transporter atp-binding protein
EML4_RS22850	COG0765	amino acid transport
EML4_RS22855	COG0765	amino acid transport
EML4_RS22860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS22865	COG3608	succinylglutamate desuccinylase aspartoacylase
EML4_RS22870	COG0006	proline dipeptidase activity
EML4_RS22875	COG2423	ornithine cyclodeaminase activity
EML4_RS22880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EML4_RS22885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4_RS22890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4_RS22895	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS22900	COG1522	sequence-specific DNA binding
EML4_RS22940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4_RS22945	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS22950	COG1126	abc transporter atp-binding protein
EML4_RS22955	COG0765	amino acid transport
EML4_RS22965	COG0583	DNA-binding transcription factor activity
EML4_RS22970	COG0596	Alpha beta hydrolase
EML4_RS22990	COG4178	(ABC) transporter
EML4_RS23000	COG4297	protein containing double-stranded beta helix domain
EML4_RS23025	COG0640	Transcriptional regulator
EML4_RS23050	COG1278	Cold shock
EML4_RS23100	COG0534	Mate efflux family protein
EML4_RS23115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EML4_RS23120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4_RS23140	COG0625	glutathione transferase activity
EML4_RS23145	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS23170	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS23180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4_RS23190	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS23200	COG1653	transport
EML4_RS23205	COG0395	ABC-type sugar transport system, permease component
EML4_RS23210	COG4209	transmembrane transport
EML4_RS23215	COG3842	ATPase activity
EML4_RS23220	COG1802	Transcriptional regulator
EML4_RS23235	COG2358	TRAP transporter, solute receptor (TAXI family
EML4_RS23250	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS23275	COG3706	GGDEF domain
EML4_RS23320	COG0668	transmembrane transport
EML4_RS23390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4_RS23415	COG4372	Transposase
EML4_RS23420	COG3436	PFAM IS66 Orf2 family protein
EML4_RS23465	COG2267	carboxylic ester hydrolase activity
EML4_RS23500	COG2161	toxin-antitoxin pair type II binding
EML4_RS23515	COG1475	DNA binding
EML4_RS23520	COG0640	Transcriptional regulator
EML4_RS23530	COG0583	DNA-binding transcription factor activity
EML4_RS23535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EML4_RS23580	COG1126	abc transporter atp-binding protein
EML4_RS23585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS23640	COG0210	DNA helicase
EML4_RS23700	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EML4_RS23700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EML4_RS23770	COG1216	Glycosyl transferase, family 2
EML4_RS23790	COG3916	Acyl-homoserine-lactone synthase
EML4_RS23800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EML4_RS23805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4_RS23840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EML4_RS23865	COG3842	ATPase activity
EML4_RS23875	COG2390	Transcriptional regulator
EML4_RS23900	COG3177	Filamentation induced by cAMP protein fic
EML4_RS23965	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS23975	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS23985	COG1733	regulation of RNA biosynthetic process
EML4_RS23990	COG1733	regulation of RNA biosynthetic process
EML4_RS24035	COG2211	Major facilitator Superfamily
EML4_RS24040	COG2807	transmembrane transport
EML4_RS24045	COG1846	Transcriptional regulator
EML4_RS24060	COG2814	Major facilitator Superfamily
EML4_RS24075	COG1522	sequence-specific DNA binding
EML4_RS24080	COG1803	Methylglyoxal synthase
EML4_RS24080	COG1597	lipid kinase activity
EML4_RS24090	COG1278	Cold shock
EML4_RS24150	COG1940	carbohydrate kinase activity
EML4_RS24150	COG1846	Transcriptional regulator
EML4_RS24170	COG1069	ribulokinase activity
EML4_RS24175	COG1349	DNA-binding transcription factor activity
EML4_RS24180	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24205	COG0395	ABC-type sugar transport system, permease component
EML4_RS24215	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EML4_RS24270	COG0583	DNA-binding transcription factor activity
EML4_RS24280	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24285	COG1846	Transcriptional regulator
EML4_RS24295	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EML4_RS24320	COG2207	Transcriptional regulator
EML4_RS24325	COG1309	transcriptional regulator
EML4_RS24330	COG0300	oxidoreductase activity
EML4_RS24335	COG1902	pentaerythritol trinitrate reductase activity
EML4_RS24340	COG0604	alcohol dehydrogenase
EML4_RS24350	COG2267	carboxylic ester hydrolase activity
EML4_RS24355	COG0667	Aldo Keto reductase
EML4_RS24365	COG1335	isochorismatase
EML4_RS24375	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24380	COG2207	Transcriptional regulator
EML4_RS24395	COG0583	DNA-binding transcription factor activity
EML4_RS24405	COG0300	oxidoreductase activity
EML4_RS24420	COG1929	Belongs to the glycerate kinase type-1 family
EML4_RS24530	COG4221	oxidoreductase activity
EML4_RS24550	COG4221	oxidoreductase activity
EML4_RS24555	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24565	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24575	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS24590	COG1741	Belongs to the pirin family
EML4_RS24595	COG0583	DNA-binding transcription factor activity
EML4_RS24615	COG2197	response regulator
EML4_RS24620	COG4585	Histidine kinase
EML4_RS24635	COG0655	NAD(P)H dehydrogenase (quinone) activity
EML4_RS24645	COG1942	4-Oxalocrotonate Tautomerase
EML4_RS24660	COG0640	Transcriptional regulator
EML4_RS24675	COG0798	PFAM Bile acid sodium symporter
EML4_RS24715	COG0753	catalase activity
EML4_RS24720	COG3685	Protein conserved in bacteria
EML4_RS24775	COG1573	uracil-dna glycosylase
EML4_RS24830	COG0583	DNA-binding transcription factor activity
EML4_RS24850	COG1396	sequence-specific DNA binding
EML4_RS24855	COG1247	-acetyltransferase
EML4_RS24865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EML4_RS24885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4_RS24890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4_RS24905	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4_RS24920	COG3177	Filamentation induced by cAMP protein fic
EML4_RS24930	COG2826	transposase and inactivated derivatives, IS30 family
EML4_RS24935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4_RS24965	COG0598	Magnesium transport protein CorA
EML4_RS24970	COG2354	Protein conserved in bacteria
EML4_RS24995	COG3920	Histidine kinase
EML4_RS25005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EML4_RS25010	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS25015	COG1414	Transcriptional regulator
EML4_RS25020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EML4_RS25025	COG3842	ATPase activity
EML4_RS25030	COG0395	ABC-type sugar transport system, permease component
EML4_RS25035	COG1175	transmembrane transport
EML4_RS25045	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS25050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS25055	COG3734	2-keto-3-deoxy-galactonokinase
EML4_RS25085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EML4_RS25105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4_RS25145	COG1609	Transcriptional regulator
EML4_RS25155	COG0583	DNA-binding transcription factor activity
EML4_RS25195	COG3505	Type IV secretory pathway VirD4
EML4_RS25205	COG0776	regulation of translation
EML4_RS25215	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EML4_RS25220	COG2948	multi-organism process
EML4_RS25225	COG3504	Conjugal transfer protein
EML4_RS25230	COG3736	Type IV secretory pathway, component VirB8
EML4_RS25240	COG3704	protein secretion by the type IV secretion system
EML4_RS25255	COG3451	type IV secretory pathway VirB4
EML4_RS25260	COG3702	type iv secretory pathway
EML4_RS25265	COG3838	Conjugal transfer protein Trbc
EML4_RS25290	COG5489	Protein of unknown function (DUF736)
EML4_RS25295	COG4974	Belongs to the 'phage' integrase family
EML4_RS25300	COG0582	viral genome integration into host DNA
EML4_RS25305	COG4974	Belongs to the 'phage' integrase family
EML4_RS25315	COG5489	Protein of unknown function (DUF736)
EML4_RS25330	COG2020	methyltransferase activity
EML4_RS25345	COG1309	transcriptional regulator
EML4_RS25360	COG1376	ErfK ybiS ycfS ynhG family protein
EML4_RS25365	COG0642	Histidine kinase
EML4_RS25380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EML4_RS25380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EML4_RS25415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4_RS25430	COG4172	Belongs to the ABC transporter superfamily
EML4_RS25440	COG0601	transmembrane transport
EML4_RS25445	COG0747	negative chemotaxis
EML4_RS25450	COG1522	sequence-specific DNA binding
EML4_RS25455	COG1012	belongs to the aldehyde dehydrogenase family
EML4_RS25460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4_RS25480	COG2207	Transcriptional regulator
EML4_RS25525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4_RS25530	COG0436	Aminotransferase
EML4_RS25545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4_RS25560	COG1126	abc transporter atp-binding protein
EML4_RS25570	COG2186	Transcriptional regulator
EML4_RS25575	COG1487	ribonuclease activity
EML4_RS25580	COG4691	Plasmid stability protein
EML4_RS25585	COG4948	Mandelate Racemase Muconate Lactonizing
EML4_RS25595	COG1802	Transcriptional regulator
EML4_RS25605	COG0601	transmembrane transport
EML4_RS25610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS25625	COG0667	Aldo Keto reductase
EML4_RS25630	COG0583	DNA-binding transcription factor activity
EML4_RS25635	COG3158	transport of potassium into the cell
EML4_RS25665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EML4_RS25670	COG0459	protein refolding
EML4_RS25715	COG3550	peptidyl-serine autophosphorylation
EML4_RS25720	COG3620	sequence-specific DNA binding
EML4_RS25750	COG2814	Major facilitator Superfamily
EML4_RS25755	COG1846	Transcriptional regulator
EML4_RS25810	COG5002	protein histidine kinase activity
EML4_RS25860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4_RS25865	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS25870	COG1129	ABC transporter
EML4_RS25880	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS25885	COG3959	Transketolase, thiamine diphosphate binding domain
EML4_RS25890	COG3958	Transketolase
EML4_RS25895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EML4_RS25900	COG2390	Transcriptional regulator
EML4_RS25910	COG4977	sequence-specific DNA binding
EML4_RS25920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EML4_RS25960	COG5001	Diguanylate cyclase
EML4_RS25960	COG3300	MHYT domain
EML4_RS25995	COG2084	Dehydrogenase
EML4_RS26000	COG3622	Belongs to the hyi family
EML4_RS26010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS26015	COG0601	transmembrane transport
EML4_RS26025	COG0747	negative chemotaxis
EML4_RS26030	COG1609	Transcriptional regulator
EML4_RS26035	COG3239	Fatty acid desaturase
EML4_RS26040	COG3706	GGDEF domain
EML4_RS26065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EML4_RS26070	COG2202	Pas domain
EML4_RS26070	COG3920	Histidine kinase
EML4_RS26085	COG1136	(ABC) transporter
EML4_RS26085	COG0577	efflux transmembrane transporter activity
EML4_RS26090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4_RS26100	COG0745	RESPONSE REGULATOR receiver
EML4_RS26155	COG0583	DNA-binding transcription factor activity
EML4_RS26175	COG0583	DNA-binding transcription factor activity
EML4_RS26190	COG1192	Involved in chromosome partitioning
EML4_RS26195	COG1475	DNA binding
EML4_RS26200	COG0640	Transcriptional regulator
EML4_RS26205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EML4_RS26250	COG0583	DNA-binding transcription factor activity
EML4_RS26260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS26265	COG1116	anion transmembrane transporter activity
EML4_RS26270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS26280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS26285	COG1028	Short-chain dehydrogenase reductase Sdr
EML4_RS26315	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4_RS26320	COG1129	ABC transporter
EML4_RS26345	COG4172	Belongs to the ABC transporter superfamily
EML4_RS26355	COG0601	transmembrane transport
EML4_RS26365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS26370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS26375	COG0583	DNA-binding transcription factor activity
EML4_RS26385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EML4_RS26395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4_RS26400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4_RS26405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4_RS26485	COG1475	DNA binding
EML4_RS26505	COG2824	Alkylphosphonate utilization operon protein PhnA
EML4_RS26525	COG5489	Protein of unknown function (DUF736)
EML4_RS26550	COG0494	nUDIX hydrolase
EML4_RS26560	COG5489	Protein of unknown function (DUF736)
EML4_RS26650	COG1283	sodium-dependent phosphate transmembrane transporter activity
EML4_RS26665	COG0747	negative chemotaxis
EML4_RS26685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4_RS26690	COG0584	glycerophosphoryl diester phosphodiesterase
EML4_RS26695	COG0483	inositol monophosphate 1-phosphatase activity
EML4_RS26755	COG3161	chorismate lyase activity
EML4_RS26900	COG3436	PFAM IS66 Orf2 family protein
EML4_RS27030	COG0145	ligase activity
EML4_RS27040	COG0583	DNA-binding transcription factor activity
EML4_RS27090	COG3701	Conjugal transfer protein
EML4_RS27095	COG3846	protein secretion by the type IV secretion system
EML4_RS27105	COG5314	conjugation
EML4_RS27110	COG3451	type IV secretory pathway VirB4
EML4_RS27125	COG4962	Type ii secretion system protein e