locus-tag	class	description
FY133_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY133_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY133_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY133_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY133_RS00025	COG1420	regulation of RNA biosynthetic process
FY133_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY133_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY133_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY133_RS00050	COG1137	ATPase activity
FY133_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY133_RS00065	COG0616	signal peptide processing
FY133_RS00070	COG0776	regulation of translation
FY133_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY133_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY133_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY133_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY133_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY133_RS00115	COG0728	peptidoglycan biosynthetic process
FY133_RS00125	COG0180	Tryptophanyl-tRNA synthetase
FY133_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY133_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
FY133_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY133_RS00165	COG1702	phosphate starvation-inducible protein PhoH
FY133_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY133_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY133_RS00185	COG1396	sequence-specific DNA binding
FY133_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY133_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY133_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS00210	COG0242	peptide deformylase activity
FY133_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY133_RS00220	COG0101	tRNA pseudouridine synthase activity
FY133_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY133_RS00235	COG2171	N-acyltransferase activity
FY133_RS00245	COG0840	transmembrane signaling receptor activity
FY133_RS00250	COG1957	nucleoside hydrolase
FY133_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY133_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY133_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY133_RS00295	COG0706	membrane insertase activity
FY133_RS00300	COG0594	ribonuclease P activity
FY133_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY133_RS00310	COG0840	transmembrane signaling receptor activity
FY133_RS00325	COG2226	methyltransferase
FY133_RS00330	COG3842	ATPase activity
FY133_RS00335	COG1175	transmembrane transport
FY133_RS00340	COG0395	ABC-type sugar transport system, permease component
FY133_RS00355	COG0427	acetyl-CoA hydrolase
FY133_RS00365	COG3938	Belongs to the proline racemase family
FY133_RS00370	COG0418	dihydroorotase activity
FY133_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY133_RS00400	COG0166	Belongs to the GPI family
FY133_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
FY133_RS00410	COG3842	ATPase activity
FY133_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
FY133_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY133_RS00425	COG4774	siderophore transport
FY133_RS00455	COG0582	viral genome integration into host DNA
FY133_RS00650	COG2326	polyphosphate kinase activity
FY133_RS00655	COG5002	protein histidine kinase activity
FY133_RS00660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY133_RS00665	COG0573	inorganic phosphate transmembrane transporter activity
FY133_RS00675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY133_RS00680	COG0704	Plays a role in the regulation of phosphate uptake
FY133_RS00685	COG0745	RESPONSE REGULATOR receiver
FY133_RS00695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY133_RS00700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY133_RS00710	COG2967	ApaG domain
FY133_RS00720	COG0717	Belongs to the dCTP deaminase family
FY133_RS00730	COG0582	viral genome integration into host DNA
FY133_RS00755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY133_RS00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS00860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY133_RS00910	COG0167	dihydroorotate dehydrogenase activity
FY133_RS00925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY133_RS00945	COG1959	2 iron, 2 sulfur cluster binding
FY133_RS00950	COG1201	RNA secondary structure unwinding
FY133_RS00980	COG1960	acyl-CoA dehydrogenase activity
FY133_RS00985	COG0183	Belongs to the thiolase family
FY133_RS00990	COG1024	Enoyl-CoA hydratase
FY133_RS00990	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY133_RS01090	COG0582	viral genome integration into host DNA
FY133_RS01115	COG1320	monovalent cation:proton antiporter activity
FY133_RS01120	COG2212	antiporter activity
FY133_RS01125	COG1863	multisubunit Na H antiporter MnhE subunit
FY133_RS01130	COG0651	ATP synthesis coupled electron transport
FY133_RS01135	COG1006	Multisubunit Na H antiporter MnhC subunit
FY133_RS01140	COG2111	Na H antiporter
FY133_RS01140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY133_RS01150	COG0840	transmembrane signaling receptor activity
FY133_RS01160	COG0745	RESPONSE REGULATOR receiver
FY133_RS01165	COG0643	Histidine kinase
FY133_RS01165	COG2198	Histidine kinase
FY133_RS01170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY133_RS01175	COG2201	protein-glutamate methylesterase activity
FY133_RS01180	COG0745	RESPONSE REGULATOR receiver
FY133_RS01185	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY133_RS01195	COG1766	The M ring may be actively involved in energy transduction
FY133_RS01200	COG2771	luxR family
FY133_RS01210	COG0840	transmembrane signaling receptor activity
FY133_RS01210	COG2972	Histidine kinase
FY133_RS01215	COG0784	Response regulator, receiver
FY133_RS01215	COG2205	protein histidine kinase activity
FY133_RS01215	COG2198	Histidine kinase
FY133_RS01220	COG1970	mechanosensitive ion channel activity
FY133_RS01225	COG0436	Aminotransferase
FY133_RS01240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY133_RS01245	COG0424	maF-like protein
FY133_RS01250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY133_RS01260	COG5328	Belongs to the UPF0262 family
FY133_RS01265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY133_RS01275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY133_RS01295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY133_RS01305	COG1338	Plays a role in the flagellum-specific transport system
FY133_RS01315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY133_RS01325	COG1706	bacterial-type flagellum-dependent cell motility
FY133_RS01330	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY133_RS01335	COG4786	Flagellar basal body rod
FY133_RS01340	COG1677	Flagellar hook-basal body complex protein FliE
FY133_RS01345	COG1558	bacterial-type flagellum-dependent cell motility
FY133_RS01350	COG1815	bacterial-type flagellum-dependent cell motility
FY133_RS01360	COG1157	protein secretion by the type III secretion system
FY133_RS01365	COG4786	Flagellar basal body rod
FY133_RS01375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY133_RS01380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY133_RS01385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY133_RS01390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY133_RS01395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY133_RS01415	COG1360	Flagellar Motor Protein
FY133_RS01440	COG1749	Flagellar hook protein flgE
FY133_RS01460	COG5443	negative regulation of bacterial-type flagellum assembly
FY133_RS01465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY133_RS01475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY133_RS01515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY133_RS01520	COG1609	Transcriptional regulator
FY133_RS01525	COG1653	transport
FY133_RS01530	COG1175	transmembrane transport
FY133_RS01535	COG0395	ABC-type sugar transport system, permease component
FY133_RS01540	COG0366	Alpha amylase catalytic
FY133_RS01545	COG3842	ATPase activity
FY133_RS01560	COG0129	dihydroxy-acid dehydratase activity
FY133_RS01565	COG0363	glucosamine-6-phosphate deaminase activity
FY133_RS01570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY133_RS01575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS01585	COG2081	HI0933 family
FY133_RS01605	COG2224	Isocitrate lyase
FY133_RS01620	COG3842	ATPase activity
FY133_RS01625	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS01630	COG1177	transmembrane transport
FY133_RS01640	COG2205	protein histidine kinase activity
FY133_RS01650	COG0248	Ppx GppA phosphatase
FY133_RS01655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY133_RS01660	COG0477	Major facilitator Superfamily
FY133_RS01690	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY133_RS01695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY133_RS01705	COG0142	geranyltranstransferase activity
FY133_RS01730	COG0752	glycyl-tRNA synthetase alpha subunit
FY133_RS01740	COG1704	LemA family
FY133_RS01745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY133_RS01755	COG0751	glycine-tRNA ligase activity
FY133_RS01760	COG1683	Conserved Protein
FY133_RS01765	COG0840	transmembrane signaling receptor activity
FY133_RS01775	COG0151	Belongs to the GarS family
FY133_RS01780	COG2183	response to ionizing radiation
FY133_RS01785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY133_RS01810	COG0583	DNA-binding transcription factor activity
FY133_RS01830	COG0306	phosphate transporter
FY133_RS01840	COG0561	phosphatase activity
FY133_RS01845	COG0438	transferase activity, transferring glycosyl groups
FY133_RS01850	COG2186	Transcriptional regulator
FY133_RS01865	COG0583	DNA-binding transcription factor activity
FY133_RS01870	COG0277	FAD linked oxidase domain protein
FY133_RS01875	COG0277	FAD linked oxidase domain protein
FY133_RS01880	COG0247	lactate metabolic process
FY133_RS01890	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS01895	COG2818	Glycosylase
FY133_RS01905	COG2855	membrane
FY133_RS01910	COG0583	DNA-binding transcription factor activity
FY133_RS01940	COG0124	histidyl-tRNA synthetase
FY133_RS01950	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY133_RS01955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY133_RS01960	COG2259	Doxx family
FY133_RS01970	COG0459	protein refolding
FY133_RS01975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY133_RS01985	COG0196	riboflavin kinase activity
FY133_RS01990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY133_RS02000	COG0590	tRNA wobble adenosine to inosine editing
FY133_RS02005	COG1187	pseudouridine synthase activity
FY133_RS02010	COG0742	ribosomal rna small subunit methyltransferase
FY133_RS02015	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY133_RS02025	COG0312	modulator of DNA gyrase
FY133_RS02030	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS02040	COG1519	Transferase
FY133_RS02050	COG1663	tetraacyldisaccharide 4'-kinase activity
FY133_RS02060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY133_RS02065	COG0745	RESPONSE REGULATOR receiver
FY133_RS02070	COG3300	MHYT domain
FY133_RS02070	COG5001	Diguanylate cyclase
FY133_RS02075	COG3386	PFAM SMP-30 Gluconolaconase
FY133_RS02080	COG0800	Aldolase
FY133_RS02085	COG3734	2-keto-3-deoxy-galactonokinase
FY133_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS02095	COG1414	Transcriptional regulator
FY133_RS02100	COG2197	response regulator
FY133_RS02115	COG0598	Magnesium transport protein CorA
FY133_RS02120	COG3158	transport of potassium into the cell
FY133_RS02135	COG0356	it plays a direct role in the translocation of protons across the membrane
FY133_RS02145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY133_RS02150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY133_RS02165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY133_RS02185	COG0009	L-threonylcarbamoyladenylate synthase
FY133_RS02195	COG4638	Rieske (2fe-2S)
FY133_RS02220	COG1960	acyl-CoA dehydrogenase activity
FY133_RS02235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY133_RS02240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY133_RS02245	COG0840	transmembrane signaling receptor activity
FY133_RS02255	COG1522	sequence-specific DNA binding
FY133_RS02280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY133_RS02285	COG1741	Belongs to the pirin family
FY133_RS02290	COG1722	exodeoxyribonuclease VII activity
FY133_RS02295	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY133_RS02300	COG1268	BioY protein
FY133_RS02305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY133_RS02310	COG1122	ATPase activity
FY133_RS02315	COG3214	Protein conserved in bacteria
FY133_RS02320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY133_RS02320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY133_RS02325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY133_RS02340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY133_RS02355	COG0259	pyridoxamine-phosphate oxidase activity
FY133_RS02385	COG0312	modulator of DNA gyrase
FY133_RS02400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY133_RS02405	COG0109	protoheme IX farnesyltransferase activity
FY133_RS02415	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY133_RS02430	COG3346	SURF1 family
FY133_RS02435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY133_RS02440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY133_RS02445	COG0328	RNA-DNA hybrid ribonuclease activity
FY133_RS02455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY133_RS02455	COG0678	peroxiredoxin activity
FY133_RS02465	COG1678	Uncharacterized ACR, COG1678
FY133_RS02470	COG3237	CsbD-like
FY133_RS02480	COG5001	Diguanylate cyclase
FY133_RS02480	COG3300	MHYT domain
FY133_RS02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY133_RS02490	COG0612	Peptidase, M16
FY133_RS02515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY133_RS02520	COG1802	Transcriptional regulator
FY133_RS02540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY133_RS02545	COG3609	addiction module antidote protein, CC2985 family
FY133_RS02550	COG3668	Plasmid stabilization system
FY133_RS02560	COG1194	a g-specific adenine glycosylase
FY133_RS02575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY133_RS02580	COG1196	nuclear chromosome segregation
FY133_RS02585	COG2514	catechol 2,3-dioxygenase activity
FY133_RS02590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY133_RS02590	COG0574	Belongs to the PEP-utilizing enzyme family
FY133_RS02605	COG1823	symporter activity
FY133_RS02630	COG0579	oxidoreductase
FY133_RS02645	COG2895	sulfate adenylyltransferase (ATP) activity
FY133_RS02650	COG0175	sulfate reduction
FY133_RS02655	COG0175	sulfate reduction
FY133_RS02660	COG1959	2 iron, 2 sulfur cluster binding
FY133_RS02665	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY133_RS02670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY133_RS02675	COG4208	sulfate ABC transporter
FY133_RS02680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY133_RS02690	COG2200	EAL domain
FY133_RS02690	COG2203	Gaf domain
FY133_RS02690	COG2199	diguanylate cyclase activity
FY133_RS02700	COG1309	transcriptional regulator
FY133_RS02705	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS02710	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY133_RS02740	COG0625	glutathione transferase activity
FY133_RS02750	COG0477	Major facilitator Superfamily
FY133_RS02760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY133_RS02760	COG1793	dna ligase
FY133_RS02780	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS02785	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS02790	COG1846	Transcriptional regulator
FY133_RS02795	COG1764	response to oxidative stress
FY133_RS02810	COG0488	(ABC) transporter
FY133_RS02845	COG4221	oxidoreductase activity
FY133_RS02860	COG0433	COG0433 Predicted ATPase
FY133_RS02870	COG1733	regulation of RNA biosynthetic process
FY133_RS02875	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY133_RS02890	COG0656	L-ascorbic acid biosynthetic process
FY133_RS02895	COG3781	membrane
FY133_RS02900	COG2378	regulation of single-species biofilm formation
FY133_RS02910	COG4106	trans-aconitate 2-methyltransferase activity
FY133_RS02915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY133_RS02920	COG0840	transmembrane signaling receptor activity
FY133_RS02925	COG0583	DNA-binding transcription factor activity
FY133_RS02940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY133_RS02960	COG3909	cytochrome
FY133_RS02965	COG2010	Cytochrome c
FY133_RS02995	COG0789	Transcriptional regulator
FY133_RS03020	COG0517	IMP dehydrogenase activity
FY133_RS03020	COG4175	Glycine betaine
FY133_RS03025	COG4176	ABC-type proline glycine betaine transport system permease component
FY133_RS03050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS03060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY133_RS03060	COG2169	Transcriptional regulator
FY133_RS03070	COG2514	catechol 2,3-dioxygenase activity
FY133_RS03085	COG1272	protein, Hemolysin III
FY133_RS03095	COG1280	lysine exporter protein (LysE YggA)
FY133_RS03100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY133_RS03105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY133_RS03105	COG2111	Na H antiporter
FY133_RS03110	COG2111	Na H antiporter
FY133_RS03115	COG1006	Multisubunit Na H antiporter MnhC subunit
FY133_RS03120	COG0651	ATP synthesis coupled electron transport
FY133_RS03125	COG1863	multisubunit Na H antiporter MnhE subunit
FY133_RS03130	COG2212	antiporter activity
FY133_RS03135	COG1320	monovalent cation:proton antiporter activity
FY133_RS03140	COG4957	zinc ion binding
FY133_RS03155	COG2166	iron-sulfur cluster assembly
FY133_RS03165	COG2205	protein histidine kinase activity
FY133_RS03210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY133_RS03215	COG2983	Belongs to the UPF0260 family
FY133_RS03225	COG3041	Addiction module toxin RelE StbE family
FY133_RS03230	COG3077	Addiction module antitoxin, RelB DinJ family
FY133_RS03240	COG2217	Heavy metal translocating P-type atpase
FY133_RS03280	COG1621	beta-fructofuranosidase activity
FY133_RS03285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY133_RS03335	COG4695	Portal protein
FY133_RS03440	COG4235	cytochrome complex assembly
FY133_RS03445	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY133_RS03450	COG1138	Cytochrome C-type biogenesis protein
FY133_RS03455	COG3088	subunit of a heme lyase
FY133_RS03460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY133_RS03465	COG0745	RESPONSE REGULATOR receiver
FY133_RS03470	COG2205	protein histidine kinase activity
FY133_RS03475	COG3011	Protein conserved in bacteria
FY133_RS03480	COG3713	MltA-interacting MipA family protein
FY133_RS03485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY133_RS03490	COG2202	Pas domain
FY133_RS03490	COG2205	protein histidine kinase activity
FY133_RS03500	COG0308	aminopeptidase N
FY133_RS03505	COG0697	spore germination
FY133_RS03520	COG0443	Heat shock 70 kDa protein
FY133_RS03555	COG0604	alcohol dehydrogenase
FY133_RS03560	COG1733	regulation of RNA biosynthetic process
FY133_RS03565	COG1968	undecaprenyl-diphosphatase activity
FY133_RS03570	COG2239	Acts as a magnesium transporter
FY133_RS03575	COG2814	Major facilitator Superfamily
FY133_RS03600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY133_RS03630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY133_RS03675	COG0741	lytic transglycosylase activity
FY133_RS03680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS03685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY133_RS03690	COG0840	transmembrane signaling receptor activity
FY133_RS03700	COG1758	RNA polymerase activity
FY133_RS03725	COG0736	holo-[acyl-carrier-protein] synthase activity
FY133_RS03730	COG0681	Belongs to the peptidase S26 family
FY133_RS03735	COG0571	ribonuclease III activity
FY133_RS03740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY133_RS03750	COG0784	Response regulator, receiver
FY133_RS03755	COG1381	Involved in DNA repair and RecF pathway recombination
FY133_RS03765	COG2226	methyltransferase
FY133_RS03775	COG1418	mRNA catabolic process
FY133_RS03785	COG0346	lactoylglutathione lyase activity
FY133_RS03800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS03805	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY133_RS03810	COG0668	transmembrane transport
FY133_RS03820	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY133_RS03850	COG1742	UPF0060 membrane protein
FY133_RS03870	COG1183	phosphatidylcholine synthase activity
FY133_RS03875	COG0688	phosphatidylethanolamine metabolic process
FY133_RS03880	COG5265	(ABC) transporter
FY133_RS03920	COG2852	Protein conserved in bacteria
FY133_RS03930	COG0215	cysteine-tRNA ligase activity
FY133_RS03935	COG4221	oxidoreductase activity
FY133_RS03940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY133_RS03945	COG1286	toxin biosynthetic process
FY133_RS03965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY133_RS03975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY133_RS03985	COG5265	(ABC) transporter
FY133_RS03990	COG0305	Participates in initiation and elongation during chromosome replication
FY133_RS04010	COG0359	binds to the 23S rRNA
FY133_RS04020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY133_RS04025	COG0360	Binds together with S18 to 16S ribosomal RNA
FY133_RS04035	COG0667	Aldo Keto reductase
FY133_RS04040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY133_RS04050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY133_RS04055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY133_RS04065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY133_RS04070	COG1561	YicC-like family, N-terminal region
FY133_RS04075	COG0194	GDP metabolic process
FY133_RS04090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY133_RS04095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY133_RS04105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY133_RS04120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY133_RS04140	COG2203	Gaf domain
FY133_RS04140	COG3706	GGDEF domain
FY133_RS04140	COG4251	negative regulation of phosphorylation
FY133_RS04140	COG5001	Diguanylate cyclase
FY133_RS04145	COG3300	MHYT domain
FY133_RS04145	COG5001	Diguanylate cyclase
FY133_RS04150	COG4191	Histidine kinase
FY133_RS04155	COG4566	intracellular signal transduction
FY133_RS04165	COG0488	(ABC) transporter
FY133_RS04170	COG3706	GGDEF domain
FY133_RS04180	COG0105	UTP biosynthetic process
FY133_RS04200	COG0314	molybdopterin synthase activity
FY133_RS04210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY133_RS04215	COG0322	excinuclease ABC activity
FY133_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS04235	COG3719	Belongs to the RNase T2 family
FY133_RS04245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY133_RS04250	COG0243	molybdopterin cofactor binding
FY133_RS04275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY133_RS04280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY133_RS04290	COG0628	permease
FY133_RS04300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY133_RS04305	COG0248	Ppx GppA phosphatase
FY133_RS04330	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY133_RS04340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY133_RS04345	COG0477	Major facilitator Superfamily
FY133_RS04350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY133_RS04360	COG0840	transmembrane signaling receptor activity
FY133_RS04365	COG0659	secondary active sulfate transmembrane transporter activity
FY133_RS04375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY133_RS04380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY133_RS04390	COG0113	porphobilinogen synthase activity
FY133_RS04410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY133_RS04415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY133_RS04420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY133_RS04420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY133_RS04430	COG1280	lysine exporter protein (LysE YggA)
FY133_RS04435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY133_RS04440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY133_RS04445	COG2814	Major facilitator Superfamily
FY133_RS04450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY133_RS04470	COG0416	fatty acid biosynthetic process
FY133_RS04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY133_RS04480	COG0776	regulation of translation
FY133_RS04515	COG0601	transmembrane transport
FY133_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS04525	COG0444	Belongs to the ABC transporter superfamily
FY133_RS04535	COG0747	negative chemotaxis
FY133_RS04545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY133_RS04550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY133_RS04565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY133_RS04570	COG0583	DNA-binding transcription factor activity
FY133_RS04575	COG0737	Belongs to the 5'-nucleotidase family
FY133_RS04595	COG2897	thiosulfate sulfurtransferase activity
FY133_RS04610	COG0415	Belongs to the DNA photolyase family
FY133_RS04620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY133_RS04650	COG3932	Exopolysaccharide synthesis, ExoD
FY133_RS04655	COG1238	metal cluster binding
FY133_RS04730	COG1612	heme a metabolic process
FY133_RS04740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY133_RS04745	COG0010	Belongs to the arginase family
FY133_RS04750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY133_RS04755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY133_RS04765	COG1832	CoA-binding protein
FY133_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS04795	COG2124	cytochrome p450
FY133_RS04800	COG2199	diguanylate cyclase activity
FY133_RS04805	COG0740	serine-type endopeptidase activity
FY133_RS04810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY133_RS04815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY133_RS04825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY133_RS04855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY133_RS04860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY133_RS04865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY133_RS04875	COG0649	NAD binding
FY133_RS04885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY133_RS04890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY133_RS04900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY133_RS04905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY133_RS04915	COG0713	ATP synthesis coupled electron transport
FY133_RS04930	COG1007	ATP synthesis coupled electron transport
FY133_RS04935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY133_RS04935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY133_RS04950	COG0442	prolyl-tRNA aminoacylation
FY133_RS04960	COG1136	(ABC) transporter
FY133_RS04975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY133_RS04995	COG0784	Response regulator, receiver
FY133_RS05005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY133_RS05010	COG0477	Major facilitator Superfamily
FY133_RS05025	COG0557	exoribonuclease II activity
FY133_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY133_RS05040	COG0758	DNA mediated transformation
FY133_RS05045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY133_RS05055	COG0540	Belongs to the ATCase OTCase family
FY133_RS05070	COG1960	acyl-CoA dehydrogenase activity
FY133_RS05075	COG0456	acetyltransferase
FY133_RS05095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY133_RS05100	COG2824	Alkylphosphonate utilization operon protein PhnA
FY133_RS05105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY133_RS05110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY133_RS05115	COG0154	amidase activity
FY133_RS05120	COG0456	acetyltransferase
FY133_RS05125	COG3811	Belongs to the UPF0386 family
FY133_RS05140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY133_RS05150	COG0456	acetyltransferase
FY133_RS05170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY133_RS05175	COG0439	Biotin carboxylase
FY133_RS05180	COG0511	ligase activity, forming carbon-carbon bonds
FY133_RS05185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY133_RS05195	COG0436	Aminotransferase
FY133_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS05220	COG1530	ribonuclease E activity
FY133_RS05230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY133_RS05250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY133_RS05255	COG0384	phenazine biosynthesis protein PhzF
FY133_RS05275	COG0633	Ferredoxin
FY133_RS05285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY133_RS05290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY133_RS05295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY133_RS05305	COG3768	UPF0283 membrane protein
FY133_RS05310	COG3106	COG3106 Predicted ATPase
FY133_RS05340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY133_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
FY133_RS05405	COG0052	Belongs to the universal ribosomal protein uS2 family
FY133_RS05410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY133_RS05415	COG0528	UMP kinase activity
FY133_RS05420	COG0233	cytoplasmic translational termination
FY133_RS05425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY133_RS05435	COG0750	zinc metalloprotease
FY133_RS05440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY133_RS05445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY133_RS05450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY133_RS05455	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY133_RS05460	COG3494	Protein of unknown function (DUF1009)
FY133_RS05465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY133_RS05470	COG2186	Transcriptional regulator
FY133_RS05480	COG0765	amino acid transport
FY133_RS05485	COG0765	amino acid transport
FY133_RS05495	COG0372	Belongs to the citrate synthase family
FY133_RS05510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY133_RS05520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY133_RS05525	COG0148	phosphopyruvate hydratase activity
FY133_RS05535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY133_RS05540	COG0022	dehydrogenase e1 component
FY133_RS05540	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY133_RS05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY133_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY133_RS05565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY133_RS05570	COG0697	spore germination
FY133_RS05590	COG2867	negative regulation of translational initiation
FY133_RS05595	COG1546	Belongs to the CinA family
FY133_RS05600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY133_RS05600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY133_RS05610	COG3852	Histidine kinase
FY133_RS05615	COG2204	response regulator
FY133_RS05620	COG5000	phosphorelay sensor kinase activity
FY133_RS05625	COG2204	response regulator
FY133_RS05635	COG1923	regulation of RNA biosynthetic process
FY133_RS05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY133_RS05645	COG3956	TIGRFAM MazG family protein
FY133_RS05655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY133_RS05655	COG1648	precorrin-2 dehydrogenase activity
FY133_RS05695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY133_RS05695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY133_RS05700	COG0509	glycine decarboxylation via glycine cleavage system
FY133_RS05705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY133_RS05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY133_RS05735	COG0564	pseudouridine synthase activity
FY133_RS05755	COG0251	oxidation-reduction process
FY133_RS05760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY133_RS05770	COG1671	Belongs to the UPF0178 family
FY133_RS05785	COG0450	alkyl hydroperoxide reductase
FY133_RS05795	COG0625	glutathione transferase activity
FY133_RS05815	COG0431	NADPH-dependent FMN reductase
FY133_RS05825	COG0798	PFAM Bile acid sodium symporter
FY133_RS05830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY133_RS05845	COG0321	lipoyl(octanoyl) transferase activity
FY133_RS05845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY133_RS05850	COG0084	hydrolase, TatD family'
FY133_RS05855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY133_RS05865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY133_RS05920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY133_RS05925	COG2095	MarC family integral membrane protein
FY133_RS05930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY133_RS05930	COG0617	tRNA 3'-terminal CCA addition
FY133_RS05930	COG0517	IMP dehydrogenase activity
FY133_RS05940	COG0629	single-stranded DNA binding
FY133_RS05945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY133_RS05955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY133_RS05975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY133_RS05980	COG1121	(ABC) transporter
FY133_RS06000	COG0667	Aldo Keto reductase
FY133_RS06010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY133_RS06090	COG2239	Acts as a magnesium transporter
FY133_RS06095	COG0243	molybdopterin cofactor binding
FY133_RS06105	COG0242	peptide deformylase activity
FY133_RS06120	COG2205	protein histidine kinase activity
FY133_RS06120	COG2202	Pas domain
FY133_RS06130	COG0321	lipoyl(octanoyl) transferase activity
FY133_RS06135	COG1064	alcohol dehydrogenase
FY133_RS06165	COG1862	Preprotein translocase
FY133_RS06185	COG2124	cytochrome p450
FY133_RS06200	COG0596	Alpha beta hydrolase
FY133_RS06210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY133_RS06215	COG0626	cystathionine gamma-synthase activity
FY133_RS06220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS06225	COG4597	amino acid ABC transporter
FY133_RS06230	COG0765	amino acid transport
FY133_RS06235	COG1126	abc transporter atp-binding protein
FY133_RS06250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY133_RS06265	COG0436	Aminotransferase
FY133_RS06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY133_RS06305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY133_RS06310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY133_RS06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY133_RS06330	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY133_RS06335	COG1489	DNA binding
FY133_RS06340	COG0024	Methionine aminopeptidase
FY133_RS06345	COG2003	Belongs to the UPF0758 family
FY133_RS06360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY133_RS06385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY133_RS06390	COG0546	phosphoglycolate phosphatase activity
FY133_RS06400	COG0114	fumarate hydratase activity
FY133_RS06410	COG0504	CTP synthase activity
FY133_RS06420	COG0149	triose-phosphate isomerase activity
FY133_RS06430	COG0187	DNA topoisomerase II activity
FY133_RS06440	COG0740	serine-type endopeptidase activity
FY133_RS06450	COG0640	Transcriptional regulator
FY133_RS06455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY133_RS06460	COG0745	RESPONSE REGULATOR receiver
FY133_RS06480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY133_RS06480	COG3264	Mechanosensitive ion channel
FY133_RS06550	COG1127	ABC transporter
FY133_RS06555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY133_RS06560	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS06570	COG0280	phosphate acetyltransferase
FY133_RS06570	COG0281	malic enzyme
FY133_RS06580	COG0778	Nitroreductase
FY133_RS06585	COG0823	Involved in the tonB-independent uptake of proteins
FY133_RS06600	COG1368	sulfuric ester hydrolase activity
FY133_RS06620	COG3265	gluconokinase activity
FY133_RS06625	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY133_RS06650	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY133_RS06670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY133_RS06685	COG0318	PFAM AMP-dependent synthetase and ligase
FY133_RS06695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY133_RS06695	COG0512	Glutamine amidotransferase of anthranilate synthase
FY133_RS06700	COG0343	queuine tRNA-ribosyltransferase activity
FY133_RS06705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY133_RS06720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY133_RS06740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY133_RS06745	COG0134	indole-3-glycerol-phosphate synthase activity
FY133_RS06750	COG0315	cyclic pyranopterin monophosphate synthase activity
FY133_RS06755	COG0303	'Molybdopterin
FY133_RS06760	COG3706	GGDEF domain
FY133_RS06770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY133_RS06770	COG0475	glutathione-regulated potassium exporter activity
FY133_RS06780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY133_RS06790	COG2814	Major facilitator Superfamily
FY133_RS06795	COG0746	molybdenum cofactor guanylyltransferase activity
FY133_RS06800	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY133_RS06805	COG0739	heme binding
FY133_RS06810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY133_RS06815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY133_RS06820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY133_RS06825	COG0805	protein transport
FY133_RS06830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY133_RS06835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY133_RS06840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY133_RS06845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY133_RS06850	COG1472	Belongs to the glycosyl hydrolase 3 family
FY133_RS06860	COG0018	arginyl-trna synthetase
FY133_RS06865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY133_RS06890	COG0525	valine-tRNA ligase activity
FY133_RS06900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY133_RS06930	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY133_RS06935	COG1058	Belongs to the CinA family
FY133_RS06935	COG1546	Belongs to the CinA family
FY133_RS06940	COG0589	response to stress
FY133_RS06945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY133_RS06960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY133_RS06970	COG0640	Transcriptional regulator
FY133_RS06975	COG1914	H( )-stimulated, divalent metal cation uptake system
FY133_RS06985	COG1132	(ABC) transporter
FY133_RS06990	COG0628	permease
FY133_RS07025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY133_RS07035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY133_RS07045	COG0302	gtp cyclohydrolase
FY133_RS07050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY133_RS07055	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY133_RS07065	COG0517	IMP dehydrogenase activity
FY133_RS07065	COG0516	GMP reductase activity
FY133_RS07095	COG1760	l-serine dehydratase
FY133_RS07135	COG0583	DNA-binding transcription factor activity
FY133_RS07145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY133_RS07145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY133_RS07155	COG0347	Belongs to the P(II) protein family
FY133_RS07160	COG0174	glutamine synthetase
FY133_RS07190	COG0697	spore germination
FY133_RS07200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY133_RS07210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY133_RS07240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY133_RS07245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY133_RS07250	COG2186	Transcriptional regulator
FY133_RS07260	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY133_RS07265	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY133_RS07270	COG3845	ABC transporter
FY133_RS07275	COG1183	phosphatidylcholine synthase activity
FY133_RS07280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY133_RS07285	COG0679	Auxin Efflux Carrier
FY133_RS07290	COG0785	Cytochrome C biogenesis protein
FY133_RS07310	COG1278	Cold shock
FY133_RS07365	COG0577	efflux transmembrane transporter activity
FY133_RS07365	COG1136	(ABC) transporter
FY133_RS07370	COG0577	efflux transmembrane transporter activity
FY133_RS07370	COG1136	(ABC) transporter
FY133_RS07395	COG2151	metal-sulfur cluster biosynthetic enzyme
FY133_RS07400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY133_RS07405	COG0719	Fe-S assembly protein
FY133_RS07410	COG0396	ATPase activity
FY133_RS07415	COG0719	Fe-S assembly protein
FY133_RS07420	COG1104	cysteine desulfurase activity
FY133_RS07425	COG2945	thiolester hydrolase activity
FY133_RS07430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY133_RS07435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY133_RS07445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY133_RS07450	COG2833	Protein of unknown function (DUF455)
FY133_RS07455	COG0739	heme binding
FY133_RS07460	COG0513	Belongs to the DEAD box helicase family
FY133_RS07485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY133_RS07495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY133_RS07500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY133_RS07505	COG0047	phosphoribosylformylglycinamidine synthase activity
FY133_RS07520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY133_RS07525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY133_RS07550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY133_RS07555	COG2814	Major facilitator Superfamily
FY133_RS07560	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS07565	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS07570	COG0037	tRNA processing
FY133_RS07575	COG2066	Belongs to the glutaminase family
FY133_RS07580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY133_RS07585	COG0861	Integral membrane protein TerC family
FY133_RS07600	COG1280	lysine exporter protein (LysE YggA)
FY133_RS07610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY133_RS07615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY133_RS07625	COG0538	isocitrate dehydrogenase activity
FY133_RS07635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY133_RS07640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY133_RS07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS07650	COG2313	pseudouridylate synthase activity
FY133_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS07665	COG4215	(ABC) transporter
FY133_RS07675	COG5425	PFAM Usg family protein
FY133_RS07685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY133_RS07690	COG1522	sequence-specific DNA binding
FY133_RS07695	COG1573	uracil-dna glycosylase
FY133_RS07705	COG2202	Pas domain
FY133_RS07705	COG2205	protein histidine kinase activity
FY133_RS07710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY133_RS07715	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY133_RS07720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY133_RS07735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY133_RS07740	COG0842	Transport permease protein
FY133_RS07745	COG1131	(ABC) transporter
FY133_RS07750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY133_RS07750	COG0730	response to heat
FY133_RS07770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY133_RS07775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY133_RS07795	COG0129	dihydroxy-acid dehydratase activity
FY133_RS07800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY133_RS07805	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY133_RS07815	COG3739	integral membrane protein
FY133_RS07820	COG0203	ribosomal protein L17
FY133_RS07825	COG0202	RNA polymerase activity
FY133_RS07830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY133_RS07835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY133_RS07840	COG0563	adenylate kinase activity
FY133_RS07845	COG0201	protein transport
FY133_RS07850	COG0200	Binds to the 23S rRNA
FY133_RS07855	COG1841	ribosomal large subunit assembly
FY133_RS07860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY133_RS07865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY133_RS07870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY133_RS07875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY133_RS07880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY133_RS07885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY133_RS07890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY133_RS07895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY133_RS07900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY133_RS07905	COG0255	Belongs to the universal ribosomal protein uL29 family
FY133_RS07910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY133_RS07915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY133_RS07920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY133_RS07925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY133_RS07930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY133_RS07935	COG0089	rRNA binding
FY133_RS07940	COG0088	Forms part of the polypeptide exit tunnel
FY133_RS07945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY133_RS07950	COG0051	transcription antitermination factor activity, RNA binding
FY133_RS07955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY133_RS07960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY133_RS07965	COG0049	tRNA binding
FY133_RS07970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY133_RS07990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY133_RS07995	COG0085	RNA polymerase activity
FY133_RS08000	COG0222	ribosome binding
FY133_RS08005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY133_RS08010	COG0081	regulation of translation
FY133_RS08015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY133_RS08025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY133_RS08035	COG1086	Polysaccharide biosynthesis protein
FY133_RS08040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY133_RS08045	COG0861	Integral membrane protein TerC family
FY133_RS08050	COG3895	Periplasmic Protein
FY133_RS08070	COG1132	(ABC) transporter
FY133_RS08075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY133_RS08095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY133_RS08130	COG2198	Histidine kinase
FY133_RS08130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS08130	COG0784	Response regulator, receiver
FY133_RS08130	COG2205	protein histidine kinase activity
FY133_RS08135	COG0784	Response regulator, receiver
FY133_RS08140	COG2202	Pas domain
FY133_RS08140	COG3920	Histidine kinase
FY133_RS08145	COG0784	Response regulator, receiver
FY133_RS08150	COG4251	negative regulation of phosphorylation
FY133_RS08165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY133_RS08170	COG1607	acyl-coa hydrolase
FY133_RS08190	COG2910	NAD(P)H-binding
FY133_RS08195	COG1733	regulation of RNA biosynthetic process
FY133_RS08210	COG0556	nucleotide-excision repair
FY133_RS08220	COG2382	esterase
FY133_RS08240	COG0484	heat shock protein binding
FY133_RS08260	COG3706	GGDEF domain
FY133_RS08280	COG1840	ABC-type Fe3 transport system, periplasmic component
FY133_RS08285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY133_RS08300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY133_RS08310	COG2207	Transcriptional regulator
FY133_RS08315	COG1064	alcohol dehydrogenase
FY133_RS08320	COG1252	NADH dehydrogenase
FY133_RS08325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY133_RS08330	COG2197	response regulator
FY133_RS08335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY133_RS08370	COG0656	L-ascorbic acid biosynthetic process
FY133_RS08385	COG0440	acetolactate synthase activity
FY133_RS08390	COG0028	Belongs to the TPP enzyme family
FY133_RS08400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY133_RS08405	COG3830	Belongs to the UPF0237 family
FY133_RS08405	COG0560	Phosphoserine phosphatase
FY133_RS08425	COG0330	HflC and HflK could
FY133_RS08430	COG0330	HflC and HflK could
FY133_RS08440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY133_RS08480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY133_RS08520	COG1335	isochorismatase
FY133_RS08550	COG2264	protein methyltransferase activity
FY133_RS08555	COG1999	signal sequence binding
FY133_RS08565	COG0835	chemotaxis
FY133_RS08575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY133_RS08580	COG0583	DNA-binding transcription factor activity
FY133_RS08590	COG1247	-acetyltransferase
FY133_RS08600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY133_RS08605	COG0497	DNA recombination
FY133_RS08610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY133_RS08620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY133_RS08625	COG0849	cell division
FY133_RS08630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY133_RS08635	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY133_RS08640	COG0477	Major facilitator Superfamily
FY133_RS08645	COG5001	Diguanylate cyclase
FY133_RS08650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY133_RS08655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY133_RS08660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY133_RS08670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY133_RS08675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY133_RS08685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY133_RS08700	COG0275	rRNA processing
FY133_RS08705	COG2001	Belongs to the MraZ family
FY133_RS08710	COG3766	membrane
FY133_RS08720	COG0754	glutathionylspermidine amidase activity
FY133_RS08745	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY133_RS08775	COG4106	trans-aconitate 2-methyltransferase activity
FY133_RS08795	COG2226	methyltransferase
FY133_RS08805	COG2267	carboxylic ester hydrolase activity
FY133_RS08810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY133_RS08840	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS08845	COG2814	Major facilitator Superfamily
FY133_RS08875	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS08880	COG0174	glutamine synthetase
FY133_RS08885	COG0531	amino acid
FY133_RS08895	COG1737	Transcriptional regulator
FY133_RS08900	COG2182	Extracellular solute-binding protein
FY133_RS08915	COG3842	ATPase activity
FY133_RS08980	COG2968	Membrane
FY133_RS08990	COG0432	Pfam Uncharacterised protein family UPF0047
FY133_RS09005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY133_RS09010	COG0358	DNA primase activity
FY133_RS09035	COG0505	Belongs to the CarA family
FY133_RS09040	COG0534	Mate efflux family protein
FY133_RS09055	COG2321	neutral zinc metallopeptidase
FY133_RS09070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY133_RS09080	COG3706	GGDEF domain
FY133_RS09095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY133_RS09105	COG1522	sequence-specific DNA binding
FY133_RS09110	COG0492	ferredoxin-NADP+ reductase activity
FY133_RS09115	COG0583	DNA-binding transcription factor activity
FY133_RS09125	COG1902	pentaerythritol trinitrate reductase activity
FY133_RS09150	COG0387	Pfam Sodium calcium exchanger
FY133_RS09155	COG0436	Aminotransferase
FY133_RS09160	COG2200	EAL domain
FY133_RS09160	COG2199	diguanylate cyclase activity
FY133_RS09175	COG1278	Cold shock
FY133_RS09180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY133_RS09190	COG1846	Transcriptional regulator
FY133_RS09195	COG0745	RESPONSE REGULATOR receiver
FY133_RS09205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY133_RS09225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY133_RS09235	COG1496	oxidoreductase activity
FY133_RS09250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY133_RS09260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FY133_RS09275	COG0840	transmembrane signaling receptor activity
FY133_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS09285	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY133_RS09290	COG3300	MHYT domain
FY133_RS09290	COG5001	Diguanylate cyclase
FY133_RS09295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY133_RS09300	COG5001	Diguanylate cyclase
FY133_RS09310	COG0193	aminoacyl-tRNA hydrolase activity
FY133_RS09320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY133_RS09345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY133_RS09355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY133_RS09355	COG2857	Cytochrome c1
FY133_RS09375	COG1132	(ABC) transporter
FY133_RS09380	COG1132	(ABC) transporter
FY133_RS09385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FY133_RS09390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY133_RS09405	COG0408	coproporphyrinogen oxidase activity
FY133_RS09420	COG0617	tRNA 3'-terminal CCA addition
FY133_RS09435	COG0714	Associated with various cellular activities
FY133_RS09455	COG0454	-acetyltransferase
FY133_RS09470	COG0477	Major facilitator Superfamily
FY133_RS09480	COG0435	Glutathione S-transferase
FY133_RS09485	COG0494	nUDIX hydrolase
FY133_RS09495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY133_RS09500	COG3135	benzoate transporter
FY133_RS09525	COG0740	serine-type endopeptidase activity
FY133_RS09540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY133_RS09545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY133_RS09570	COG4175	Glycine betaine
FY133_RS09590	COG1435	thymidine kinase activity
FY133_RS09615	COG1629	transport
FY133_RS09615	COG4771	TonB-dependent receptor
FY133_RS09625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY133_RS09625	COG0512	Glutamine amidotransferase of anthranilate synthase
FY133_RS09640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY133_RS09650	COG0366	Alpha amylase catalytic
FY133_RS09655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS09675	COG1160	GTP binding
FY133_RS09695	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY133_RS09705	COG0024	Methionine aminopeptidase
FY133_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS09735	COG0583	DNA-binding transcription factor activity
FY133_RS09750	COG0402	S-adenosylhomocysteine deaminase activity
FY133_RS09760	COG1304	FMN binding
FY133_RS09770	COG1309	transcriptional regulator
FY133_RS09775	COG1686	Belongs to the peptidase S11 family
FY133_RS09785	COG2351	hydroxyisourate hydrolase activity
FY133_RS09790	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY133_RS09815	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY133_RS09825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY133_RS09825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS09835	COG0513	Belongs to the DEAD box helicase family
FY133_RS09845	COG2259	Doxx family
FY133_RS09850	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS09860	COG2308	Evidence 4 Homologs of previously reported genes of
FY133_RS09870	COG1305	Transglutaminase-like
FY133_RS09895	COG4214	carbohydrate transport
FY133_RS09905	COG4213	ABC transporter substrate-binding protein
FY133_RS09940	COG0840	transmembrane signaling receptor activity
FY133_RS09955	COG0646	methionine synthase
FY133_RS09955	COG1410	methionine synthase
FY133_RS10000	COG1215	transferase activity, transferring glycosyl groups
FY133_RS10030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY133_RS10035	COG2346	COG2346, Truncated hemoglobins
FY133_RS10055	COG1309	transcriptional regulator
FY133_RS10070	COG0494	nUDIX hydrolase
FY133_RS10080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS10115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY133_RS10120	COG0830	nickel cation binding
FY133_RS10125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY133_RS10140	COG0804	urea catabolic process
FY133_RS10145	COG1442	glycosyl transferase family 8
FY133_RS10150	COG3755	Protein conserved in bacteria
FY133_RS10160	COG0832	Belongs to the urease beta subunit family
FY133_RS10165	COG3813	Protein conserved in bacteria
FY133_RS10170	COG0831	urea catabolic process
FY133_RS10175	COG0829	nickel cation binding
FY133_RS10195	COG0411	ABC transporter
FY133_RS10205	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY133_RS10220	COG0174	glutamine synthetase
FY133_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS10230	COG0784	Response regulator, receiver
FY133_RS10230	COG2198	Histidine kinase
FY133_RS10230	COG5002	protein histidine kinase activity
FY133_RS10245	COG0726	polysaccharide deacetylase
FY133_RS10280	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY133_RS10355	COG0564	pseudouridine synthase activity
FY133_RS10365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY133_RS10375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY133_RS10400	COG0346	lactoylglutathione lyase activity
FY133_RS10410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY133_RS10420	COG2832	Protein of unknown function (DUF454)
FY133_RS10425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY133_RS10430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS10435	COG4558	Periplasmic binding protein
FY133_RS10445	COG3721	Heme iron utilization protein
FY133_RS10460	COG3655	Transcriptional regulator
FY133_RS10475	COG3657	addiction module killer protein
FY133_RS10485	COG2205	protein histidine kinase activity
FY133_RS10525	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS10530	COG4605	iron ion homeostasis
FY133_RS10535	COG4604	ABC transporter, ATP-binding protein
FY133_RS10540	COG0783	Belongs to the Dps family
FY133_RS10555	COG2972	Histidine kinase
FY133_RS10555	COG0840	transmembrane signaling receptor activity
FY133_RS10560	COG0656	L-ascorbic acid biosynthetic process
FY133_RS10565	COG2814	Major facilitator Superfamily
FY133_RS10575	COG0583	DNA-binding transcription factor activity
FY133_RS10580	COG0657	acetylesterase activity
FY133_RS10585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS10605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY133_RS10610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY133_RS10615	COG0288	reversible hydration of carbon dioxide
FY133_RS10625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY133_RS10640	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY133_RS10645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY133_RS10650	COG0778	Nitroreductase
FY133_RS10655	COG2267	carboxylic ester hydrolase activity
FY133_RS10660	COG0251	oxidation-reduction process
FY133_RS10665	COG1335	isochorismatase
FY133_RS10670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS10680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS10695	COG1175	transmembrane transport
FY133_RS10700	COG0395	ABC-type sugar transport system, permease component
FY133_RS10705	COG3842	ATPase activity
FY133_RS10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS10720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY133_RS10735	COG4608	Belongs to the ABC transporter superfamily
FY133_RS10740	COG0444	Belongs to the ABC transporter superfamily
FY133_RS10745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS10750	COG0601	transmembrane transport
FY133_RS10805	COG2159	amidohydrolase
FY133_RS10810	COG1960	acyl-CoA dehydrogenase activity
FY133_RS10840	COG0745	RESPONSE REGULATOR receiver
FY133_RS10850	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY133_RS10850	COG1902	pentaerythritol trinitrate reductase activity
FY133_RS10855	COG3842	ATPase activity
FY133_RS10865	COG1840	ABC-type Fe3 transport system, periplasmic component
FY133_RS10870	COG1840	ABC-type Fe3 transport system, periplasmic component
FY133_RS10875	COG0745	RESPONSE REGULATOR receiver
FY133_RS10885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY133_RS10890	COG0583	DNA-binding transcription factor activity
FY133_RS10895	COG1278	Cold shock
FY133_RS10905	COG0662	Cupin 2, conserved barrel domain protein
FY133_RS10905	COG2207	Transcriptional regulator
FY133_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS10925	COG0667	Aldo Keto reductase
FY133_RS10940	COG1309	transcriptional regulator
FY133_RS10950	COG0604	alcohol dehydrogenase
FY133_RS10955	COG0667	Aldo Keto reductase
FY133_RS10975	COG1846	Transcriptional regulator
FY133_RS10990	COG0577	efflux transmembrane transporter activity
FY133_RS10990	COG1136	(ABC) transporter
FY133_RS10995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS11025	COG3209	COG3209 Rhs family protein
FY133_RS11055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS11080	COG3177	Filamentation induced by cAMP protein fic
FY133_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS11095	COG1414	Transcriptional regulator
FY133_RS11100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY133_RS11105	COG3842	ATPase activity
FY133_RS11110	COG0395	ABC-type sugar transport system, permease component
FY133_RS11115	COG1175	transmembrane transport
FY133_RS11125	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS11130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS11135	COG3734	2-keto-3-deoxy-galactonokinase
FY133_RS11155	COG0583	DNA-binding transcription factor activity
FY133_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS11195	COG0667	Aldo Keto reductase
FY133_RS11205	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS11215	COG0789	Transcriptional regulator
FY133_RS11230	COG0673	inositol 2-dehydrogenase activity
FY133_RS11235	COG2267	carboxylic ester hydrolase activity
FY133_RS11250	COG0583	DNA-binding transcription factor activity
FY133_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS11260	COG0583	DNA-binding transcription factor activity
FY133_RS11270	COG1063	alcohol dehydrogenase
FY133_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS11285	COG0673	inositol 2-dehydrogenase activity
FY133_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS11335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY133_RS11340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY133_RS11430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY133_RS11435	COG1309	transcriptional regulator
FY133_RS11440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS11445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY133_RS11455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY133_RS11460	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY133_RS11480	COG0583	DNA-binding transcription factor activity
FY133_RS11485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS11490	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY133_RS11495	COG4149	molybdate abc transporter
FY133_RS11500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY133_RS11515	COG2022	thiamine diphosphate biosynthetic process
FY133_RS11530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY133_RS11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY133_RS11545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY133_RS11565	COG1132	(ABC) transporter
FY133_RS11570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY133_RS11615	COG4166	transmembrane transport
FY133_RS11620	COG0601	transmembrane transport
FY133_RS11625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS11640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY133_RS11645	COG3142	Participates in the control of copper homeostasis
FY133_RS11650	COG2814	Major facilitator Superfamily
FY133_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS11670	COG1737	Transcriptional regulator
FY133_RS11680	COG3842	ATPase activity
FY133_RS11690	COG0395	ABC-type sugar transport system, permease component
FY133_RS11710	COG2188	Transcriptional regulator
FY133_RS11715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY133_RS11720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY133_RS11725	COG1940	carbohydrate kinase activity
FY133_RS11735	COG0671	phosphoesterase, PA-phosphatase related
FY133_RS11740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY133_RS11745	COG0156	8-amino-7-oxononanoate synthase activity
FY133_RS11755	COG0729	surface antigen
FY133_RS11765	COG0835	chemotaxis
FY133_RS11775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY133_RS11780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY133_RS11785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY133_RS11790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY133_RS11795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY133_RS11800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY133_RS11815	COG4974	Belongs to the 'phage' integrase family
FY133_RS11840	COG1280	lysine exporter protein (LysE YggA)
FY133_RS11850	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY133_RS11855	COG0567	Dehydrogenase, E1 component
FY133_RS11860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY133_RS11865	COG0045	succinate-CoA ligase (ADP-forming) activity
FY133_RS11870	COG0039	L-malate dehydrogenase activity
FY133_RS11875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY133_RS11910	COG2264	protein methyltransferase activity
FY133_RS11925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY133_RS11930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY133_RS11935	COG0181	hydroxymethylbilane synthase activity
FY133_RS11975	COG1872	DUF167
FY133_RS11980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY133_RS11990	COG1217	gtp-binding protein TYPA
FY133_RS11995	COG0339	signal peptide processing
FY133_RS12000	COG1846	Transcriptional regulator
FY133_RS12010	COG0137	argininosuccinate synthase activity
FY133_RS12020	COG1280	lysine exporter protein (LysE YggA)
FY133_RS12025	COG1122	ATPase activity
FY133_RS12030	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY133_RS12040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY133_RS12055	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY133_RS12060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY133_RS12065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY133_RS12075	COG4181	ATPase activity
FY133_RS12085	COG0670	Belongs to the BI1 family
FY133_RS12100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY133_RS12105	COG4133	protoheme IX ABC transporter activity
FY133_RS12110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY133_RS12115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY133_RS12140	COG2917	probably involved in intracellular septation
FY133_RS12145	COG0552	protein localization to endoplasmic reticulum
FY133_RS12150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY133_RS12155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY133_RS12170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY133_RS12175	COG1605	Chorismate mutase
FY133_RS12175	COG0287	Prephenate dehydrogenase
FY133_RS12180	COG0228	four-way junction DNA binding
FY133_RS12185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY133_RS12190	COG0336	Belongs to the RNA methyltransferase TrmD family
FY133_RS12200	COG0335	large ribosomal subunit rRNA binding
FY133_RS12205	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY133_RS12210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS12225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY133_RS12245	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY133_RS12265	COG0488	(ABC) transporter
FY133_RS12275	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY133_RS12285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY133_RS12290	COG0142	geranyltranstransferase activity
FY133_RS12295	COG2885	chlorophyll binding
FY133_RS12300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY133_RS12305	COG2223	nitrite transmembrane transporter activity
FY133_RS12310	COG1349	DNA-binding transcription factor activity
FY133_RS12315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY133_RS12320	COG2197	response regulator
FY133_RS12325	COG1132	(ABC) transporter
FY133_RS12330	COG3459	Glycosyltransferase 36 associated
FY133_RS12335	COG1473	amidohydrolase
FY133_RS12345	COG0579	oxidoreductase
FY133_RS12355	COG0129	dihydroxy-acid dehydratase activity
FY133_RS12360	COG2084	Dehydrogenase
FY133_RS12365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS12370	COG0277	FAD linked oxidase domain protein
FY133_RS12375	COG2186	Transcriptional regulator
FY133_RS12385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY133_RS12390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY133_RS12395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY133_RS12400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY133_RS12410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY133_RS12415	COG0495	leucyl-tRNA aminoacylation
FY133_RS12430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY133_RS12435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY133_RS12450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY133_RS12455	COG1946	Acyl-CoA thioesterase
FY133_RS12460	COG0347	Belongs to the P(II) protein family
FY133_RS12465	COG0004	ammonium transporteR
FY133_RS12470	COG1674	ftsk spoiiie
FY133_RS12475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY133_RS12490	COG0745	RESPONSE REGULATOR receiver
FY133_RS12500	COG1329	Transcriptional regulator
FY133_RS12505	COG2902	Dehydrogenase
FY133_RS12510	COG2270	Major facilitator Superfamily
FY133_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS12540	COG0494	nUDIX hydrolase
FY133_RS12545	COG2861	carbohydrate metabolic process
FY133_RS12550	COG0793	Belongs to the peptidase S41A family
FY133_RS12560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY133_RS12565	COG0799	negative regulation of ribosome biogenesis
FY133_RS12570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY133_RS12575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY133_RS12580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY133_RS12585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY133_RS12600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY133_RS12605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY133_RS12630	COG0066	3-isopropylmalate dehydratase activity
FY133_RS12635	COG0473	3-isopropylmalate dehydrogenase activity
FY133_RS12640	COG1858	cytochrome C peroxidase
FY133_RS12645	COG1797	cobyrinic acid a,c-diamide synthase activity
FY133_RS12655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY133_RS12720	COG1492	cobalamin metabolic process
FY133_RS12735	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS12740	COG3254	rhamnose metabolic process
FY133_RS12750	COG1063	alcohol dehydrogenase
FY133_RS12775	COG1129	ABC transporter
FY133_RS12780	COG2186	Transcriptional regulator
FY133_RS12785	COG2721	sulfolactate sulfo-lyase activity
FY133_RS12790	COG0138	bifunctional purine biosynthesis protein purh
FY133_RS12800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY133_RS12800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY133_RS12805	COG0501	Belongs to the peptidase M48B family
FY133_RS12825	COG0357	Ribosomal RNA small subunit methyltransferase G
FY133_RS12830	COG0445	tRNA wobble uridine modification
FY133_RS12835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY133_RS12840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY133_RS12845	COG1981	membrane
FY133_RS12850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY133_RS12855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY133_RS12860	COG0424	maF-like protein
FY133_RS12865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY133_RS12870	COG0237	dephospho-CoA kinase activity
FY133_RS12880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY133_RS12885	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY133_RS12895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY133_RS12920	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY133_RS12935	COG0135	phosphoribosylanthranilate isomerase activity
FY133_RS12940	COG0133	tryptophan synthase activity
FY133_RS12945	COG0159	tryptophan synthase activity
FY133_RS12950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY133_RS12965	COG1074	ATP-dependent DNA helicase activity
FY133_RS12975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY133_RS12980	COG0802	atpase or kinase
FY133_RS12985	COG2205	protein histidine kinase activity
FY133_RS12990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY133_RS12995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY133_RS13000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY133_RS13000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY133_RS13005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY133_RS13010	COG0642	Histidine kinase
FY133_RS13015	COG0745	RESPONSE REGULATOR receiver
FY133_RS13020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY133_RS13030	COG1652	LysM domain
FY133_RS13035	COG1072	(Pantothenic acid kinase))
FY133_RS13040	COG0140	phosphoribosyl-ATP diphosphatase activity
FY133_RS13045	COG0107	imidazoleglycerol-phosphate synthase activity
FY133_RS13050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY133_RS13055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY133_RS13065	COG0131	Imidazoleglycerol-phosphate dehydratase
FY133_RS13070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY133_RS13075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY133_RS13085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY133_RS13100	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY133_RS13110	COG1643	Atp-dependent helicase
FY133_RS13170	COG1072	(Pantothenic acid kinase))
FY133_RS13180	COG1780	Probably involved in ribonucleotide reductase function
FY133_RS13200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY133_RS13230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS13240	COG2813	Specifically methylates the guanine in position
FY133_RS13245	COG1185	polyribonucleotide nucleotidyltransferase activity
FY133_RS13250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY133_RS13255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY133_RS13260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY133_RS13265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY133_RS13265	COG3064	Membrane
FY133_RS13280	COG0779	Required for maturation of 30S ribosomal subunits
FY133_RS13285	COG2814	Major facilitator Superfamily
FY133_RS13295	COG2951	lytic endotransglycosylase activity
FY133_RS13300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY133_RS13310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY133_RS13315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY133_RS13330	COG2816	NAD+ diphosphatase activity
FY133_RS13335	COG0077	Prephenate dehydratase
FY133_RS13335	COG1605	Chorismate mutase
FY133_RS13340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY133_RS13345	COG3474	cytochrome
FY133_RS13355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY133_RS13360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY133_RS13365	COG1278	Cold shock
FY133_RS13370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY133_RS13380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY133_RS13380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY133_RS13390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY133_RS13420	COG2900	Belongs to the SlyX family
FY133_RS13430	COG0484	heat shock protein binding
FY133_RS13435	COG0443	Heat shock 70 kDa protein
FY133_RS13450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY133_RS13455	COG1744	ABC transporter substrate-binding protein PnrA-like
FY133_RS13460	COG3845	ABC transporter
FY133_RS13465	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY133_RS13470	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY133_RS13475	COG0295	cytidine deaminase activity
FY133_RS13485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY133_RS13490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY133_RS13500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY133_RS13505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY133_RS13510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY133_RS13520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY133_RS13525	COG1845	cytochrome c oxidase, subunit III
FY133_RS13530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY133_RS13535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY133_RS13540	COG0477	Major facilitator Superfamily
FY133_RS13545	COG0070	glutamate synthase
FY133_RS13545	COG0067	glutamate synthase
FY133_RS13545	COG0069	glutamate synthase activity
FY133_RS13550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY133_RS13565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY133_RS13575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY133_RS13605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS13625	COG0848	biopolymer transport protein
FY133_RS13635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY133_RS13650	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY133_RS13655	COG3454	Phosphonate metabolism
FY133_RS13660	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY133_RS13665	COG3639	organic phosphonate transmembrane transporter activity
FY133_RS13670	COG3639	organic phosphonate transmembrane transporter activity
FY133_RS13675	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FY133_RS13680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY133_RS13690	COG4778	phosphonate C-P lyase system protein PhnL
FY133_RS13695	COG4107	phosphonate C-P lyase system protein PhnK
FY133_RS13700	COG3627	carbon phosphorus lyase activity
FY133_RS13705	COG3626	phosphonate metabolism
FY133_RS13710	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY133_RS13715	COG3624	Phosphonate C-P lyase system protein PhnG
FY133_RS13720	COG2188	Transcriptional regulator
FY133_RS13725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY133_RS13730	COG0837	glucose binding
FY133_RS13735	COG1803	Methylglyoxal synthase
FY133_RS13740	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY133_RS13745	COG4166	transmembrane transport
FY133_RS13750	COG4174	ABC transporter (Permease)
FY133_RS13755	COG4239	(ABC) transporter, permease
FY133_RS13760	COG4172	Belongs to the ABC transporter superfamily
FY133_RS13765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS13770	COG0174	glutamine synthetase
FY133_RS13775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS13780	COG3265	gluconokinase activity
FY133_RS13785	COG1174	glycine betaine transport
FY133_RS13790	COG1125	glycine betaine transport
FY133_RS13795	COG1174	glycine betaine transport
FY133_RS13800	COG1732	Glycine betaine
FY133_RS13810	COG1959	2 iron, 2 sulfur cluster binding
FY133_RS13815	COG1840	ABC-type Fe3 transport system, periplasmic component
FY133_RS13825	COG4269	membrane
FY133_RS13840	COG0697	spore germination
FY133_RS13855	COG0791	NLP P60 protein
FY133_RS13865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY133_RS13870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY133_RS13905	COG4964	Belongs to the GSP D family
FY133_RS13950	COG3422	double-strand break repair
FY133_RS13955	COG3757	hydrolase, family 25
FY133_RS13960	COG0697	spore germination
FY133_RS13965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY133_RS13980	COG0492	ferredoxin-NADP+ reductase activity
FY133_RS13995	COG0481	GTPase activity
FY133_RS14000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY133_RS14015	COG1396	sequence-specific DNA binding
FY133_RS14030	COG1917	Cupin 2, conserved barrel domain protein
FY133_RS14030	COG2169	Transcriptional regulator
FY133_RS14035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY133_RS14060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY133_RS14065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY133_RS14070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY133_RS14080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY133_RS14085	COG0072	phenylalanine-tRNA ligase activity
FY133_RS14085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY133_RS14090	COG0667	Aldo Keto reductase
FY133_RS14110	COG4977	sequence-specific DNA binding
FY133_RS14135	COG1570	exodeoxyribonuclease VII activity
FY133_RS14140	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS14150	COG1846	Transcriptional regulator
FY133_RS14155	COG0697	spore germination
FY133_RS14160	COG2309	aminopeptidase activity
FY133_RS14165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY133_RS14170	COG1393	Belongs to the ArsC family
FY133_RS14190	COG1309	transcriptional regulator
FY133_RS14200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY133_RS14200	COG0519	Catalyzes the synthesis of GMP from XMP
FY133_RS14215	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY133_RS14245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY133_RS14255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY133_RS14265	COG1968	undecaprenyl-diphosphatase activity
FY133_RS14280	COG0284	orotidine-5'-phosphate decarboxylase activity
FY133_RS14290	COG3963	phosphatidate phosphatase activity
FY133_RS14300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY133_RS14305	COG0792	nuclease activity
FY133_RS14320	COG1175	transmembrane transport
FY133_RS14325	COG0395	ABC-type sugar transport system, permease component
FY133_RS14330	COG3842	ATPase activity
FY133_RS14340	COG0189	ligase activity
FY133_RS14350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY133_RS14355	COG1280	lysine exporter protein (LysE YggA)
FY133_RS14360	COG0756	dUTP diphosphatase activity
FY133_RS14365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY133_RS14370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY133_RS14385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY133_RS14390	COG2226	methyltransferase
FY133_RS14395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY133_RS14400	COG1024	Enoyl-CoA hydratase
FY133_RS14405	COG0268	Binds directly to 16S ribosomal RNA
FY133_RS14435	COG1278	Cold shock
FY133_RS14470	COG0411	ABC transporter
FY133_RS14480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY133_RS14485	COG1454	alcohol dehydrogenase
FY133_RS14490	COG0747	negative chemotaxis
FY133_RS14495	COG0601	transmembrane transport
FY133_RS14505	COG4608	Belongs to the ABC transporter superfamily
FY133_RS14510	COG1349	DNA-binding transcription factor activity
FY133_RS14515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY133_RS14540	COG4302	ethanolamine ammonia-lyase activity
FY133_RS14545	COG0025	NhaP-type Na H and K H
FY133_RS14550	COG4106	trans-aconitate 2-methyltransferase activity
FY133_RS14565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS14570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS14575	COG0601	transmembrane transport
FY133_RS14600	COG4172	Belongs to the ABC transporter superfamily
FY133_RS14605	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FY133_RS14635	COG0596	Alpha beta hydrolase
FY133_RS14650	COG1764	response to oxidative stress
FY133_RS14660	COG0596	Alpha beta hydrolase
FY133_RS14680	COG0783	Belongs to the Dps family
FY133_RS14685	COG0243	molybdopterin cofactor binding
FY133_RS14695	COG4566	intracellular signal transduction
FY133_RS14700	COG4566	intracellular signal transduction
FY133_RS14710	COG2140	Oxalate decarboxylase
FY133_RS14730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY133_RS14740	COG1414	Transcriptional regulator
FY133_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS14775	COG1522	sequence-specific DNA binding
FY133_RS14795	COG0628	permease
FY133_RS14805	COG2235	arginine
FY133_RS14840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY133_RS14850	COG0702	epimerase
FY133_RS14855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY133_RS14860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS14865	COG0745	RESPONSE REGULATOR receiver
FY133_RS14870	COG5002	protein histidine kinase activity
FY133_RS14885	COG2233	PERMEase
FY133_RS14945	COG0395	ABC-type sugar transport system, permease component
FY133_RS14950	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS14960	COG3842	ATPase activity
FY133_RS14995	COG1653	transport
FY133_RS15005	COG0395	ABC-type sugar transport system, permease component
FY133_RS15010	COG3842	ATPase activity
FY133_RS15025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY133_RS15030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS15035	COG1116	anion transmembrane transporter activity
FY133_RS15040	COG0395	ABC-type sugar transport system, permease component
FY133_RS15045	COG1175	transmembrane transport
FY133_RS15075	COG1609	Transcriptional regulator
FY133_RS15090	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS15105	COG3842	ATPase activity
FY133_RS15110	COG0395	ABC-type sugar transport system, permease component
FY133_RS15115	COG1175	transmembrane transport
FY133_RS15120	COG1653	transport
FY133_RS15125	COG1309	transcriptional regulator
FY133_RS15130	COG0673	inositol 2-dehydrogenase activity
FY133_RS15145	COG0673	inositol 2-dehydrogenase activity
FY133_RS15155	COG1278	Cold shock
FY133_RS15165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY133_RS15190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY133_RS15195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY133_RS15210	COG3842	ATPase activity
FY133_RS15215	COG0395	ABC-type sugar transport system, permease component
FY133_RS15220	COG1175	transmembrane transport
FY133_RS15230	COG3618	amidohydrolase
FY133_RS15235	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS15240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS15245	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS15250	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY133_RS15255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS15260	COG2186	Transcriptional regulator
FY133_RS15275	COG0667	Aldo Keto reductase
FY133_RS15305	COG4977	sequence-specific DNA binding
FY133_RS15310	COG2223	nitrite transmembrane transporter activity
FY133_RS15315	COG1609	Transcriptional regulator
FY133_RS15320	COG1063	alcohol dehydrogenase
FY133_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS15335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS15340	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY133_RS15345	COG1175	transmembrane transport
FY133_RS15350	COG0395	ABC-type sugar transport system, permease component
FY133_RS15365	COG0395	ABC-type sugar transport system, permease component
FY133_RS15375	COG2182	Extracellular solute-binding protein
FY133_RS15380	COG0626	cystathionine gamma-synthase activity
FY133_RS15395	COG0454	-acetyltransferase
FY133_RS15400	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY133_RS15410	COG1121	(ABC) transporter
FY133_RS15415	COG0523	cobalamin synthesis protein
FY133_RS15430	COG0523	cobalamin synthesis protein
FY133_RS15435	COG1653	transport
FY133_RS15440	COG1175	transmembrane transport
FY133_RS15445	COG0395	ABC-type sugar transport system, permease component
FY133_RS15450	COG3842	ATPase activity
FY133_RS15460	COG3047	cAMP biosynthetic process
FY133_RS15485	COG0583	DNA-binding transcription factor activity
FY133_RS15490	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS15495	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS15500	COG1129	ABC transporter
FY133_RS15510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY133_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS15525	COG3257	ureidoglycine aminohydrolase activity
FY133_RS15535	COG5001	Diguanylate cyclase
FY133_RS15540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY133_RS15550	COG0747	negative chemotaxis
FY133_RS15555	COG0601	transmembrane transport
FY133_RS15560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS15570	COG4608	Belongs to the ABC transporter superfamily
FY133_RS15575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY133_RS15590	COG0346	lactoylglutathione lyase activity
FY133_RS15600	COG0129	dihydroxy-acid dehydratase activity
FY133_RS15605	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS15610	COG1129	ABC transporter
FY133_RS15615	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS15620	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS15625	COG2186	Transcriptional regulator
FY133_RS15640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY133_RS15645	COG0587	DNA-directed DNA polymerase activity
FY133_RS15675	COG0673	inositol 2-dehydrogenase activity
FY133_RS15685	COG3842	ATPase activity
FY133_RS15690	COG0395	ABC-type sugar transport system, permease component
FY133_RS15695	COG1175	transmembrane transport
FY133_RS15700	COG1653	transport
FY133_RS15710	COG0673	inositol 2-dehydrogenase activity
FY133_RS15725	COG5001	Diguanylate cyclase
FY133_RS15740	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY133_RS15745	COG2894	cell division
FY133_RS15750	COG0850	regulation of cytokinetic process
FY133_RS15755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY133_RS15760	COG2186	Transcriptional regulator
FY133_RS15765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY133_RS15775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY133_RS15780	COG1063	alcohol dehydrogenase
FY133_RS15785	COG1312	Catalyzes the dehydration of D-mannonate
FY133_RS15805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY133_RS15810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY133_RS15810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY133_RS15815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS15830	COG0625	glutathione transferase activity
FY133_RS15835	COG4172	Belongs to the ABC transporter superfamily
FY133_RS15840	COG1921	L-seryl-tRNASec selenium transferase activity
FY133_RS15855	COG3964	amidohydrolase
FY133_RS15865	COG0601	transmembrane transport
FY133_RS15870	COG0747	negative chemotaxis
FY133_RS15875	COG0438	transferase activity, transferring glycosyl groups
FY133_RS15910	COG4989	oxidoreductase activity
FY133_RS15920	COG2188	Transcriptional regulator
FY133_RS15925	COG3842	ATPase activity
FY133_RS15930	COG1653	transport
FY133_RS15935	COG1175	transmembrane transport
FY133_RS15940	COG0395	ABC-type sugar transport system, permease component
FY133_RS15945	COG1501	Belongs to the glycosyl hydrolase 31 family
FY133_RS15955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS15960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY133_RS15965	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY133_RS15970	COG0352	thiamine-phosphate diphosphorylase activity
FY133_RS15975	COG0351	phosphomethylpyrimidine kinase
FY133_RS15980	COG1522	sequence-specific DNA binding
FY133_RS15985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY133_RS15990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS16005	COG2204	response regulator
FY133_RS16010	COG4191	Histidine kinase
FY133_RS16015	COG1301	dicarboxylic acid transport
FY133_RS16020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY133_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS16035	COG1473	amidohydrolase
FY133_RS16055	COG1215	transferase activity, transferring glycosyl groups
FY133_RS16065	COG2942	2-epimerase
FY133_RS16090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS16100	COG2197	response regulator
FY133_RS16130	COG3307	-O-antigen
FY133_RS16135	COG1596	polysaccharide export
FY133_RS16140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY133_RS16150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY133_RS16155	COG0840	transmembrane signaling receptor activity
FY133_RS16160	COG1376	ErfK ybiS ycfS ynhG family protein
FY133_RS16170	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS16180	COG2094	Belongs to the DNA glycosylase MPG family
FY133_RS16195	COG1609	Transcriptional regulator
FY133_RS16200	COG1653	transport
FY133_RS16215	COG3842	ATPase activity
FY133_RS16225	COG0673	inositol 2-dehydrogenase activity
FY133_RS16230	COG0602	queuosine metabolic process
FY133_RS16235	COG0720	synthase
FY133_RS16240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY133_RS16250	COG0673	inositol 2-dehydrogenase activity
FY133_RS16265	COG0395	ABC-type sugar transport system, permease component
FY133_RS16270	COG1175	transmembrane transport
FY133_RS16295	COG0583	DNA-binding transcription factor activity
FY133_RS16300	COG0281	malic enzyme
FY133_RS16300	COG0280	phosphate acetyltransferase
FY133_RS16315	COG0765	amino acid transport
FY133_RS16320	COG1126	abc transporter atp-binding protein
FY133_RS16325	COG2079	MmgE PrpD family protein
FY133_RS16330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS16355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY133_RS16365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY133_RS16370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY133_RS16375	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS16380	COG1129	ABC transporter
FY133_RS16395	COG1473	amidohydrolase
FY133_RS16400	COG0747	negative chemotaxis
FY133_RS16415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS16420	COG0601	transmembrane transport
FY133_RS16425	COG0583	DNA-binding transcription factor activity
FY133_RS16430	COG1446	asparaginase
FY133_RS16445	COG0747	negative chemotaxis
FY133_RS16465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS16470	COG0601	transmembrane transport
FY133_RS16475	COG2197	response regulator
FY133_RS16480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY133_RS16485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS16495	COG3842	ATPase activity
FY133_RS16500	COG0395	ABC-type sugar transport system, permease component
FY133_RS16505	COG1175	transmembrane transport
FY133_RS16515	COG0673	inositol 2-dehydrogenase activity
FY133_RS16520	COG0673	inositol 2-dehydrogenase activity
FY133_RS16540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS16545	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY133_RS16565	COG1595	DNA-templated transcription, initiation
FY133_RS16570	COG1120	ATPase activity
FY133_RS16575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS16590	COG2226	methyltransferase
FY133_RS16600	COG1120	ATPase activity
FY133_RS16605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS16625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY133_RS16650	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS16655	COG0473	3-isopropylmalate dehydrogenase activity
FY133_RS16660	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS16665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS16700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS16705	COG4172	Belongs to the ABC transporter superfamily
FY133_RS16710	COG1522	sequence-specific DNA binding
FY133_RS16720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS16735	COG0583	DNA-binding transcription factor activity
FY133_RS16745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS16750	COG1126	abc transporter atp-binding protein
FY133_RS16765	COG1473	amidohydrolase
FY133_RS16770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16780	COG1959	2 iron, 2 sulfur cluster binding
FY133_RS16790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY133_RS16795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16825	COG1960	acyl-CoA dehydrogenase activity
FY133_RS16835	COG0747	negative chemotaxis
FY133_RS16850	COG0444	Belongs to the ABC transporter superfamily
FY133_RS16860	COG0667	Aldo Keto reductase
FY133_RS16870	COG0583	DNA-binding transcription factor activity
FY133_RS16875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16880	COG4166	transmembrane transport
FY133_RS16890	COG0747	negative chemotaxis
FY133_RS16895	COG1473	amidohydrolase
FY133_RS16900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS16940	COG4608	Belongs to the ABC transporter superfamily
FY133_RS16945	COG0444	Belongs to the ABC transporter superfamily
FY133_RS16955	COG0601	transmembrane transport
FY133_RS16965	COG2186	Transcriptional regulator
FY133_RS16980	COG0300	oxidoreductase activity
FY133_RS16990	COG3453	Protein conserved in bacteria
FY133_RS16990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY133_RS16995	COG0640	Transcriptional regulator
FY133_RS17005	COG2391	methyltransferase activity
FY133_RS17010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY133_RS17020	COG0022	dehydrogenase e1 component
FY133_RS17030	COG1960	acyl-CoA dehydrogenase activity
FY133_RS17035	COG0183	Belongs to the thiolase family
FY133_RS17045	COG1960	acyl-CoA dehydrogenase activity
FY133_RS17050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY133_RS17070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY133_RS17075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY133_RS17080	COG4952	isomerase
FY133_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS17085	COG3347	Dehydrogenase
FY133_RS17090	COG1349	DNA-binding transcription factor activity
FY133_RS17100	COG1129	ABC transporter
FY133_RS17105	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS17110	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS17115	COG3254	rhamnose metabolic process
FY133_RS17130	COG2264	protein methyltransferase activity
FY133_RS17135	COG5001	Diguanylate cyclase
FY133_RS17150	COG4335	DNA alkylation repair
FY133_RS17155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY133_RS17160	COG4208	sulfate ABC transporter
FY133_RS17170	COG4150	thiosulfate binding
FY133_RS17175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY133_RS17190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY133_RS17200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY133_RS17210	COG1040	competence protein
FY133_RS17215	COG2226	methyltransferase
FY133_RS17230	COG0494	nUDIX hydrolase
FY133_RS17240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY133_RS17245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY133_RS17250	COG0653	protein targeting
FY133_RS17255	COG0697	spore germination
FY133_RS17320	COG2244	polysaccharide biosynthetic process
FY133_RS17335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY133_RS17345	COG0489	protein tyrosine kinase activity
FY133_RS17345	COG3206	protein involved in exopolysaccharide biosynthesis
FY133_RS17360	COG0438	transferase activity, transferring glycosyl groups
FY133_RS17365	COG0438	transferase activity, transferring glycosyl groups
FY133_RS17370	COG0438	transferase activity, transferring glycosyl groups
FY133_RS17385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY133_RS17390	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY133_RS17390	COG2273	Hydrolase Family 16
FY133_RS17405	COG3842	ATPase activity
FY133_RS17410	COG3833	ABC-type maltose transport systems, permease component
FY133_RS17465	COG1396	sequence-specific DNA binding
FY133_RS17475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY133_RS17480	COG1129	ABC transporter
FY133_RS17485	COG4214	carbohydrate transport
FY133_RS17490	COG4213	ABC transporter substrate-binding protein
FY133_RS17505	COG0346	lactoylglutathione lyase activity
FY133_RS17510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY133_RS17510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY133_RS17515	COG4770	biotin carboxylase activity
FY133_RS17530	COG0625	glutathione transferase activity
FY133_RS17535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY133_RS17540	COG1396	sequence-specific DNA binding
FY133_RS17540	COG3800	Transcriptional regulator
FY133_RS17550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY133_RS17560	COG0300	oxidoreductase activity
FY133_RS17570	COG2096	Adenosyltransferase
FY133_RS17580	COG2086	electron transfer activity
FY133_RS17590	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY133_RS17600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY133_RS17605	COG0165	Argininosuccinate lyase
FY133_RS17640	COG2884	Cell division ATP-binding protein ftsE
FY133_RS17660	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY133_RS17670	COG0287	Prephenate dehydrogenase
FY133_RS17675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY133_RS17680	COG2226	methyltransferase
FY133_RS17685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY133_RS17705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY133_RS17710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY133_RS17750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY133_RS17755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY133_RS17765	COG4974	Belongs to the 'phage' integrase family
FY133_RS17770	COG0825	malonyl-CoA metabolic process
FY133_RS17775	COG3034	peptidoglycan biosynthetic process
FY133_RS17780	COG0425	Belongs to the sulfur carrier protein TusA family
FY133_RS17780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY133_RS17785	COG0523	cobalamin synthesis protein
FY133_RS17790	COG1686	Belongs to the peptidase S11 family
FY133_RS17795	COG1473	amidohydrolase
FY133_RS17805	COG4953	penicillin-binding protein 1C
FY133_RS17810	COG2373	Large extracellular alpha-helical protein
FY133_RS17815	COG2835	tetraacyldisaccharide 4'-kinase activity
FY133_RS17845	COG0482	sulfurtransferase activity
FY133_RS17860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY133_RS17875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY133_RS17880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY133_RS17885	COG0037	tRNA processing
FY133_RS17895	COG2885	chlorophyll binding
FY133_RS17900	COG0823	Involved in the tonB-independent uptake of proteins
FY133_RS17920	COG0824	Thioesterase
FY133_RS17930	COG0494	nUDIX hydrolase
FY133_RS17945	COG2255	four-way junction helicase activity
FY133_RS17950	COG0632	four-way junction helicase activity
FY133_RS17955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY133_RS17960	COG0840	transmembrane signaling receptor activity
FY133_RS17965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS17970	COG0217	transcriptional regulatory protein
FY133_RS17985	COG1692	metallophosphoesterase
FY133_RS17995	COG1253	flavin adenine dinucleotide binding
FY133_RS18035	COG0126	phosphoglycerate kinase activity
FY133_RS18040	COG3588	fructose-bisphosphate aldolase
FY133_RS18065	COG0254	rRNA binding
FY133_RS18070	COG1132	(ABC) transporter
FY133_RS18090	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS18120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY133_RS18125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY133_RS18130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY133_RS18135	COG0457	Tetratricopeptide repeat
FY133_RS18140	COG3750	Belongs to the UPF0335 family
FY133_RS18160	COG0469	pyruvate kinase activity
FY133_RS18165	COG3108	Peptidase M15
FY133_RS18170	COG2204	response regulator
FY133_RS18175	COG1164	Oligoendopeptidase f
FY133_RS18180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY133_RS18190	COG5310	Homospermidine synthase
FY133_RS18200	COG0737	Belongs to the 5'-nucleotidase family
FY133_RS18205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY133_RS18210	COG0330	HflC and HflK could
FY133_RS18240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY133_RS18245	COG2951	lytic endotransglycosylase activity
FY133_RS18260	COG2205	protein histidine kinase activity
FY133_RS18275	COG0069	glutamate synthase activity
FY133_RS18275	COG0067	glutamate synthase
FY133_RS18275	COG0070	glutamate synthase
FY133_RS18290	COG2205	protein histidine kinase activity
FY133_RS18295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY133_RS18300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY133_RS18310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY133_RS18320	COG0252	asparaginase activity
FY133_RS18330	COG1027	Aspartate ammonia-lyase
FY133_RS18335	COG2186	Transcriptional regulator
FY133_RS18355	COG1309	transcriptional regulator
FY133_RS18375	COG4176	ABC-type proline glycine betaine transport system permease component
FY133_RS18380	COG4175	Glycine betaine
FY133_RS18380	COG0517	IMP dehydrogenase activity
FY133_RS18385	COG2986	histidine ammonia-lyase
FY133_RS18390	COG1609	Transcriptional regulator
FY133_RS18410	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS18415	COG0673	inositol 2-dehydrogenase activity
FY133_RS18420	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS18445	COG3550	peptidyl-serine autophosphorylation
FY133_RS18490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FY133_RS18505	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FY133_RS18530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS18540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS18545	COG0601	transmembrane transport
FY133_RS18550	COG0747	negative chemotaxis
FY133_RS18560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY133_RS18565	COG1454	alcohol dehydrogenase
FY133_RS18605	COG2307	Protein conserved in bacteria
FY133_RS18605	COG2308	Evidence 4 Homologs of previously reported genes of
FY133_RS18620	COG0488	(ABC) transporter
FY133_RS18625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY133_RS18630	COG2186	Transcriptional regulator
FY133_RS18645	COG1175	transmembrane transport
FY133_RS18650	COG0395	ABC-type sugar transport system, permease component
FY133_RS18660	COG3842	ATPase activity
FY133_RS18685	COG1304	FMN binding
FY133_RS18700	COG1063	alcohol dehydrogenase
FY133_RS18705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY133_RS18710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS18720	COG0765	amino acid transport
FY133_RS18725	COG0765	amino acid transport
FY133_RS18730	COG4221	oxidoreductase activity
FY133_RS18735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY133_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS18745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS18760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY133_RS18775	COG0697	spore germination
FY133_RS18780	COG0697	spore germination
FY133_RS18785	COG0511	ligase activity, forming carbon-carbon bonds
FY133_RS18790	COG0439	Biotin carboxylase
FY133_RS18800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY133_RS18805	COG1984	allophanate hydrolase subunit 2
FY133_RS18810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY133_RS18815	COG3842	ATPase activity
FY133_RS18825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY133_RS18835	COG0436	Aminotransferase
FY133_RS18850	COG0840	transmembrane signaling receptor activity
FY133_RS18855	COG1070	Carbohydrate kinase
FY133_RS18860	COG1830	Aldolase
FY133_RS18865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY133_RS18870	COG0667	Aldo Keto reductase
FY133_RS18880	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS18885	COG1129	ABC transporter
FY133_RS18890	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS18925	COG0071	Belongs to the small heat shock protein (HSP20) family
FY133_RS18940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY133_RS18955	COG0395	ABC-type sugar transport system, permease component
FY133_RS18970	COG3842	ATPase activity
FY133_RS18985	COG1648	precorrin-2 dehydrogenase activity
FY133_RS18985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY133_RS18990	COG0243	molybdopterin cofactor binding
FY133_RS19000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY133_RS19005	COG1116	anion transmembrane transporter activity
FY133_RS19010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS19015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY133_RS19025	COG3707	response regulator
FY133_RS19030	COG1802	Transcriptional regulator
FY133_RS19035	COG1914	H( )-stimulated, divalent metal cation uptake system
FY133_RS19040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY133_RS19045	COG4336	lyase activity
FY133_RS19050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY133_RS19055	COG4770	biotin carboxylase activity
FY133_RS19060	COG0366	Alpha amylase catalytic
FY133_RS19070	COG4771	TonB-dependent receptor
FY133_RS19075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY133_RS19095	COG1414	Transcriptional regulator
FY133_RS19100	COG1475	DNA binding
FY133_RS19105	COG1192	Involved in chromosome partitioning
FY133_RS19135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY133_RS19145	COG2986	histidine ammonia-lyase
FY133_RS19150	COG1228	amidohydrolase
FY133_RS19155	COG0402	S-adenosylhomocysteine deaminase activity
FY133_RS19195	COG4172	Belongs to the ABC transporter superfamily
FY133_RS19200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS19205	COG0601	transmembrane transport
FY133_RS19210	COG4166	transmembrane transport
FY133_RS19215	COG0395	ABC-type sugar transport system, permease component
FY133_RS19230	COG1566	PFAM secretion protein HlyD family protein
FY133_RS19245	COG2207	Transcriptional regulator
FY133_RS19250	COG1309	transcriptional regulator
FY133_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS19280	COG1846	Transcriptional regulator
FY133_RS19285	COG0583	DNA-binding transcription factor activity
FY133_RS19290	COG2828	Protein conserved in bacteria
FY133_RS19305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS19320	COG0840	transmembrane signaling receptor activity
FY133_RS19340	COG1215	transferase activity, transferring glycosyl groups
FY133_RS19370	COG0583	DNA-binding transcription factor activity
FY133_RS19375	COG0346	lactoylglutathione lyase activity
FY133_RS19390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY133_RS19410	COG0583	DNA-binding transcription factor activity
FY133_RS19415	COG0477	Major facilitator Superfamily
FY133_RS19430	COG2205	protein histidine kinase activity
FY133_RS19435	COG0745	RESPONSE REGULATOR receiver
FY133_RS19440	COG0671	phosphoesterase, PA-phosphatase related
FY133_RS19490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY133_RS19495	COG0156	8-amino-7-oxononanoate synthase activity
FY133_RS19500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY133_RS19505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY133_RS19510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY133_RS19525	COG0010	Belongs to the arginase family
FY133_RS19535	COG0697	spore germination
FY133_RS19540	COG0673	inositol 2-dehydrogenase activity
FY133_RS19560	COG0477	Major facilitator Superfamily
FY133_RS19575	COG2194	sulfuric ester hydrolase activity
FY133_RS19585	COG0583	DNA-binding transcription factor activity
FY133_RS19590	COG4774	siderophore transport
FY133_RS19605	COG1120	ATPase activity
FY133_RS19615	COG3474	cytochrome
FY133_RS19620	COG2137	regulation of response to DNA damage stimulus
FY133_RS19625	COG3386	PFAM SMP-30 Gluconolaconase
FY133_RS19635	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS19640	COG1129	ABC transporter
FY133_RS19645	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS19650	COG4585	Histidine kinase
FY133_RS19655	COG2197	response regulator
FY133_RS19665	COG2133	pyrroloquinoline quinone binding
FY133_RS19675	COG0500	methyltransferase
FY133_RS19680	COG0564	pseudouridine synthase activity
FY133_RS19695	COG4175	Glycine betaine
FY133_RS19695	COG3448	diguanylate cyclase activity
FY133_RS19700	COG4176	ABC-type proline glycine betaine transport system permease component
FY133_RS19715	COG4191	Histidine kinase
FY133_RS19715	COG0784	Response regulator, receiver
FY133_RS19720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY133_RS19725	COG0489	protein tyrosine kinase activity
FY133_RS19725	COG3206	protein involved in exopolysaccharide biosynthesis
FY133_RS19730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY133_RS19735	COG1215	transferase activity, transferring glycosyl groups
FY133_RS19740	COG1215	transferase activity, transferring glycosyl groups
FY133_RS19745	COG1215	transferase activity, transferring glycosyl groups
FY133_RS19750	COG0438	transferase activity, transferring glycosyl groups
FY133_RS19755	COG2273	Hydrolase Family 16
FY133_RS19760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY133_RS19765	COG2244	polysaccharide biosynthetic process
FY133_RS19770	COG0463	Glycosyl transferase, family 2
FY133_RS19775	COG2327	Polysaccharide pyruvyl transferase
FY133_RS19780	COG1215	transferase activity, transferring glycosyl groups
FY133_RS19800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY133_RS19805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS19820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY133_RS19820	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY133_RS19850	COG1523	belongs to the glycosyl hydrolase 13 family
FY133_RS19855	COG0033	Phosphoglucomutase
FY133_RS19860	COG0297	glycogen (starch) synthase activity
FY133_RS19865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY133_RS19870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY133_RS19875	COG0058	SHG alpha-glucan phosphorylase activity
FY133_RS19890	COG1794	racemase activity, acting on amino acids and derivatives
FY133_RS19895	COG1522	sequence-specific DNA binding
FY133_RS19905	COG2084	Dehydrogenase
FY133_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS19915	COG1063	alcohol dehydrogenase
FY133_RS19925	COG4988	ABC transporter
FY133_RS19930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY133_RS19940	COG1294	oxidase, subunit
FY133_RS19970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY133_RS19975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY133_RS20005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY133_RS20010	COG0539	negative regulation of cytoplasmic translation
FY133_RS20040	COG4221	oxidoreductase activity
FY133_RS20050	COG0747	negative chemotaxis
FY133_RS20055	COG0601	transmembrane transport
FY133_RS20060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS20065	COG0444	Belongs to the ABC transporter superfamily
FY133_RS20070	COG4608	Belongs to the ABC transporter superfamily
FY133_RS20075	COG0246	Mannitol dehydrogenase
FY133_RS20090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS20135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY133_RS20140	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS20155	COG4993	Dehydrogenase
FY133_RS20160	COG3685	Protein conserved in bacteria
FY133_RS20190	COG0693	protein deglycase activity
FY133_RS20210	COG0189	ligase activity
FY133_RS20215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY133_RS20220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY133_RS20235	COG0435	Glutathione S-transferase
FY133_RS20240	COG0583	DNA-binding transcription factor activity
FY133_RS20245	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS20250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY133_RS20255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY133_RS20260	COG1116	anion transmembrane transporter activity
FY133_RS20270	COG1522	sequence-specific DNA binding
FY133_RS20285	COG0784	Response regulator, receiver
FY133_RS20305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY133_RS20320	COG0019	diaminopimelate decarboxylase activity
FY133_RS20335	COG0527	aspartate kinase activity
FY133_RS20345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY133_RS20350	COG2890	protein-(glutamine-N5) methyltransferase activity
FY133_RS20360	COG0542	response to heat
FY133_RS20365	COG0741	lytic transglycosylase activity
FY133_RS20365	COG1196	nuclear chromosome segregation
FY133_RS20365	COG0739	heme binding
FY133_RS20400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY133_RS20405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY133_RS20415	COG1280	lysine exporter protein (LysE YggA)
FY133_RS20430	COG1309	transcriptional regulator
FY133_RS20435	COG4221	oxidoreductase activity
FY133_RS20440	COG1902	pentaerythritol trinitrate reductase activity
FY133_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS20455	COG0604	alcohol dehydrogenase
FY133_RS20475	COG1278	Cold shock
FY133_RS20495	COG0753	catalase activity
FY133_RS20520	COG3920	Histidine kinase
FY133_RS20540	COG1129	ABC transporter
FY133_RS20545	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS20550	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS20575	COG0667	Aldo Keto reductase
FY133_RS20590	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS20595	COG1129	ABC transporter
FY133_RS20600	COG4213	ABC transporter substrate-binding protein
FY133_RS20620	COG4608	Belongs to the ABC transporter superfamily
FY133_RS20625	COG0444	Belongs to the ABC transporter superfamily
FY133_RS20630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS20635	COG0601	transmembrane transport
FY133_RS20640	COG0747	negative chemotaxis
FY133_RS20665	COG0765	amino acid transport
FY133_RS20670	COG4597	amino acid ABC transporter
FY133_RS20675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS20715	COG3077	Addiction module antitoxin, RelB DinJ family
FY133_RS20730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY133_RS20735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY133_RS20755	COG0625	glutathione transferase activity
FY133_RS20760	COG4221	oxidoreductase activity
FY133_RS20770	COG2376	Dihydroxyacetone kinase
FY133_RS20775	COG1522	sequence-specific DNA binding
FY133_RS20795	COG0431	NADPH-dependent FMN reductase
FY133_RS20805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS20815	COG4172	Belongs to the ABC transporter superfamily
FY133_RS20820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS20840	COG0277	FAD linked oxidase domain protein
FY133_RS20860	COG0778	Nitroreductase
FY133_RS20890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY133_RS20915	COG2318	DinB family
FY133_RS20920	COG0583	DNA-binding transcription factor activity
FY133_RS20935	COG1335	isochorismatase
FY133_RS20960	COG3842	ATPase activity
FY133_RS20965	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS20970	COG1177	transmembrane transport
FY133_RS20975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY133_RS20985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY133_RS21000	COG1120	ATPase activity
FY133_RS21005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS21010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS21015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FY133_RS21020	COG1629	transport
FY133_RS21020	COG4774	siderophore transport
FY133_RS21025	COG4702	Belongs to the UPF0303 family
FY133_RS21045	COG1024	Enoyl-CoA hydratase
FY133_RS21050	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS21055	COG1653	transport
FY133_RS21060	COG1175	transmembrane transport
FY133_RS21065	COG0395	ABC-type sugar transport system, permease component
FY133_RS21070	COG3842	ATPase activity
FY133_RS21095	COG3474	cytochrome
FY133_RS21100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY133_RS21105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY133_RS21110	COG1845	cytochrome c oxidase, subunit III
FY133_RS21135	COG1136	(ABC) transporter
FY133_RS21135	COG0577	efflux transmembrane transporter activity
FY133_RS21200	COG3842	ATPase activity
FY133_RS21210	COG1177	transmembrane transport
FY133_RS21215	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS21230	COG1940	carbohydrate kinase activity
FY133_RS21250	COG1069	ribulokinase activity
FY133_RS21255	COG1349	DNA-binding transcription factor activity
FY133_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS21285	COG0395	ABC-type sugar transport system, permease component
FY133_RS21295	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY133_RS21320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY133_RS21330	COG0477	Major facilitator Superfamily
FY133_RS21370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FY133_RS21380	COG1733	regulation of RNA biosynthetic process
FY133_RS21415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY133_RS21420	COG3938	Belongs to the proline racemase family
FY133_RS21430	COG4176	ABC-type proline glycine betaine transport system permease component
FY133_RS21435	COG4175	Glycine betaine
FY133_RS21435	COG3448	diguanylate cyclase activity
FY133_RS21445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS21450	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS21455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS21465	COG0047	phosphoribosylformylglycinamidine synthase activity
FY133_RS21470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS21480	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY133_RS21480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY133_RS21490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY133_RS21510	COG1309	transcriptional regulator
FY133_RS21525	COG1136	(ABC) transporter
FY133_RS21540	COG1063	alcohol dehydrogenase
FY133_RS21550	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS21560	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS21580	COG0477	Major facilitator Superfamily
FY133_RS21720	COG3300	MHYT domain
FY133_RS21720	COG5001	Diguanylate cyclase
FY133_RS21745	COG1253	flavin adenine dinucleotide binding
FY133_RS21760	COG3842	ATPase activity
FY133_RS21765	COG0395	ABC-type sugar transport system, permease component
FY133_RS21770	COG1175	transmembrane transport
FY133_RS21775	COG1653	transport
FY133_RS21785	COG0673	inositol 2-dehydrogenase activity
FY133_RS21790	COG1609	Transcriptional regulator
FY133_RS21805	COG0583	DNA-binding transcription factor activity
FY133_RS21815	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS21820	COG1129	ABC transporter
FY133_RS21825	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS21830	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS21835	COG1609	Transcriptional regulator
FY133_RS21845	COG0673	inositol 2-dehydrogenase activity
FY133_RS21905	COG0714	Associated with various cellular activities
FY133_RS21910	COG3256	nitric oxide reductase
FY133_RS21945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY133_RS21950	COG3189	MarR family transcriptional regulator
FY133_RS21960	COG0826	peptidase U32
FY133_RS21985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FY133_RS21995	COG4459	periplasmic nitrate reductase
FY133_RS22010	COG0243	molybdopterin cofactor binding
FY133_RS22020	COG3005	denitrification pathway
FY133_RS22025	COG0583	DNA-binding transcription factor activity
FY133_RS22045	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY133_RS22050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS22065	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS22070	COG1535	isochorismatase
FY133_RS22070	COG3433	isochorismatase activity
FY133_RS22075	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY133_RS22080	COG1169	isochorismate synthase
FY133_RS22090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY133_RS22090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY133_RS22095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY133_RS22105	COG2375	cellular response to nickel ion
FY133_RS22115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS22120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS22130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS22140	COG1629	transport
FY133_RS22140	COG4774	siderophore transport
FY133_RS22145	COG1960	acyl-CoA dehydrogenase activity
FY133_RS22150	COG0583	DNA-binding transcription factor activity
FY133_RS22155	COG1609	Transcriptional regulator
FY133_RS22165	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS22175	COG3842	ATPase activity
FY133_RS22185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY133_RS22190	COG0583	DNA-binding transcription factor activity
FY133_RS22195	COG2814	Major facilitator Superfamily
FY133_RS22200	COG1473	amidohydrolase
FY133_RS22205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY133_RS22215	COG0747	negative chemotaxis
FY133_RS22220	COG0601	transmembrane transport
FY133_RS22225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS22230	COG0444	Belongs to the ABC transporter superfamily
FY133_RS22235	COG4608	Belongs to the ABC transporter superfamily
FY133_RS22240	COG0583	DNA-binding transcription factor activity
FY133_RS22245	COG0747	negative chemotaxis
FY133_RS22250	COG0601	transmembrane transport
FY133_RS22255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS22260	COG0154	amidase activity
FY133_RS22265	COG0693	protein deglycase activity
FY133_RS22275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS22280	COG0601	transmembrane transport
FY133_RS22290	COG1473	amidohydrolase
FY133_RS22295	COG4172	Belongs to the ABC transporter superfamily
FY133_RS22300	COG2390	Transcriptional regulator
FY133_RS22310	COG1175	transmembrane transport
FY133_RS22315	COG0395	ABC-type sugar transport system, permease component
FY133_RS22340	COG1069	ribulokinase activity
FY133_RS22365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY133_RS22375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY133_RS22380	COG1414	Transcriptional regulator
FY133_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS22395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY133_RS22400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY133_RS22405	COG1121	(ABC) transporter
FY133_RS22410	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY133_RS22420	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY133_RS22425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY133_RS22435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY133_RS22440	COG0471	metal ion transport
FY133_RS22440	COG3273	potassium ion transport
FY133_RS22445	COG1253	flavin adenine dinucleotide binding
FY133_RS22450	COG1309	transcriptional regulator
FY133_RS22470	COG1609	Transcriptional regulator
FY133_RS22475	COG1070	Carbohydrate kinase
FY133_RS22480	COG2115	Belongs to the xylose isomerase family
FY133_RS22495	COG0778	Nitroreductase
FY133_RS22500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY133_RS22505	COG2011	ABC-type metal ion transport system permease component
FY133_RS22515	COG3300	MHYT domain
FY133_RS22515	COG5001	Diguanylate cyclase
FY133_RS22520	COG1054	Belongs to the UPF0176 family
FY133_RS22530	COG2954	triphosphatase activity
FY133_RS22535	COG0800	Aldolase
FY133_RS22555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY133_RS22590	COG0523	cobalamin synthesis protein
FY133_RS22600	COG1846	Transcriptional regulator
FY133_RS22605	COG1609	Transcriptional regulator
FY133_RS22610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY133_RS22620	COG3718	enzyme involved in inositol metabolism
FY133_RS22630	COG3962	Belongs to the TPP enzyme family
FY133_RS22635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS22650	COG0411	ABC transporter
FY133_RS22665	COG0683	leucine binding
FY133_RS22680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS22690	COG0747	negative chemotaxis
FY133_RS22695	COG4172	Belongs to the ABC transporter superfamily
FY133_RS22720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY133_RS22725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY133_RS22730	COG1126	abc transporter atp-binding protein
FY133_RS22735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS22740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS22745	COG0765	amino acid transport
FY133_RS22750	COG0765	amino acid transport
FY133_RS22755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY133_RS22760	COG3485	protocatechuate 3,4-dioxygenase
FY133_RS22765	COG3485	protocatechuate 3,4-dioxygenase
FY133_RS22770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY133_RS22780	COG0583	DNA-binding transcription factor activity
FY133_RS22795	COG1414	Transcriptional regulator
FY133_RS22805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY133_RS22810	COG0183	Belongs to the thiolase family
FY133_RS22815	COG1609	Transcriptional regulator
FY133_RS22830	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS22835	COG0673	inositol 2-dehydrogenase activity
FY133_RS22845	COG1609	Transcriptional regulator
FY133_RS22850	COG0395	ABC-type sugar transport system, permease component
FY133_RS22855	COG1175	transmembrane transport
FY133_RS22860	COG3842	ATPase activity
FY133_RS22870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY133_RS22890	COG2814	Major facilitator Superfamily
FY133_RS22895	COG4774	siderophore transport
FY133_RS22900	COG3712	iron ion homeostasis
FY133_RS22910	COG1940	carbohydrate kinase activity
FY133_RS22915	COG0584	glycerophosphoryl diester phosphodiesterase
FY133_RS22920	COG0300	oxidoreductase activity
FY133_RS22935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY133_RS22955	COG0667	Aldo Keto reductase
FY133_RS22960	COG0583	DNA-binding transcription factor activity
FY133_RS22970	COG1132	(ABC) transporter
FY133_RS22975	COG0275	rRNA processing
FY133_RS22985	COG0673	inositol 2-dehydrogenase activity
FY133_RS23010	COG3754	Rhamnan synthesis protein F
FY133_RS23025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY133_RS23030	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY133_RS23035	COG1088	dTDP-glucose 4,6-dehydratase activity
FY133_RS23040	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY133_RS23045	COG0210	DNA helicase
FY133_RS23055	COG1609	Transcriptional regulator
FY133_RS23060	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY133_RS23060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY133_RS23075	COG0395	ABC-type sugar transport system, permease component
FY133_RS23080	COG3842	ATPase activity
FY133_RS23090	COG0444	Belongs to the ABC transporter superfamily
FY133_RS23095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS23100	COG0601	transmembrane transport
FY133_RS23105	COG2186	Transcriptional regulator
FY133_RS23125	COG5001	Diguanylate cyclase
FY133_RS23125	COG3300	MHYT domain
FY133_RS23130	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS23140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY133_RS23150	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY133_RS23155	COG0306	phosphate transporter
FY133_RS23160	COG1392	Phosphate transport regulator
FY133_RS23175	COG1566	PFAM secretion protein HlyD family protein
FY133_RS23180	COG0745	RESPONSE REGULATOR receiver
FY133_RS23185	COG2205	protein histidine kinase activity
FY133_RS23200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY133_RS23215	COG4774	siderophore transport
FY133_RS23225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS23230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS23235	COG1120	ATPase activity
FY133_RS23240	COG0583	DNA-binding transcription factor activity
FY133_RS23250	COG3119	arylsulfatase activity
FY133_RS23255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY133_RS23260	COG3842	ATPase activity
FY133_RS23265	COG0165	Argininosuccinate lyase
FY133_RS23270	COG0395	ABC-type sugar transport system, permease component
FY133_RS23275	COG1175	transmembrane transport
FY133_RS23280	COG2182	Extracellular solute-binding protein
FY133_RS23285	COG1940	carbohydrate kinase activity
FY133_RS23310	COG1486	melibiose metabolic process
FY133_RS23315	COG0747	negative chemotaxis
FY133_RS23320	COG0601	transmembrane transport
FY133_RS23325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS23330	COG4172	Belongs to the ABC transporter superfamily
FY133_RS23335	COG1486	melibiose metabolic process
FY133_RS23340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY133_RS23345	COG0842	Transport permease protein
FY133_RS23345	COG1129	ABC transporter
FY133_RS23350	COG0842	Transport permease protein
FY133_RS23365	COG0784	Response regulator, receiver
FY133_RS23370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY133_RS23380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS23385	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY133_RS23400	COG0765	amino acid transport
FY133_RS23410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS23420	COG3938	Belongs to the proline racemase family
FY133_RS23435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS23440	COG0765	amino acid transport
FY133_RS23445	COG0765	amino acid transport
FY133_RS23455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY133_RS23470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY133_RS23500	COG2223	nitrite transmembrane transporter activity
FY133_RS23505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY133_RS23515	COG2186	Transcriptional regulator
FY133_RS23520	COG0747	negative chemotaxis
FY133_RS23525	COG0601	transmembrane transport
FY133_RS23530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS23535	COG4172	Belongs to the ABC transporter superfamily
FY133_RS23540	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS23550	COG2186	Transcriptional regulator
FY133_RS23555	COG0747	negative chemotaxis
FY133_RS23560	COG0601	transmembrane transport
FY133_RS23565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS23570	COG0405	Gamma-glutamyltransferase
FY133_RS23580	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS23590	COG3842	ATPase activity
FY133_RS23595	COG0395	ABC-type sugar transport system, permease component
FY133_RS23615	COG3237	CsbD-like
FY133_RS23625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY133_RS23630	COG3181	Tripartite tricarboxylate transporter family receptor
FY133_RS23635	COG5265	(ABC) transporter
FY133_RS23640	COG0488	(ABC) transporter
FY133_RS23665	COG1049	propionate catabolic process, 2-methylcitrate cycle
FY133_RS23670	COG0110	maltose O-acetyltransferase activity
FY133_RS23680	COG1063	alcohol dehydrogenase
FY133_RS23685	COG3284	Transcriptional regulator
FY133_RS23705	COG1129	ABC transporter
FY133_RS23710	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS23715	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS23725	COG0572	uridine kinase
FY133_RS23730	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS23760	COG4178	(ABC) transporter
FY133_RS23795	COG0640	Transcriptional regulator
FY133_RS23810	COG2274	protein secretion by the type I secretion system
FY133_RS23825	COG1192	Involved in chromosome partitioning
FY133_RS23830	COG1475	DNA binding
FY133_RS23835	COG0640	Transcriptional regulator
FY133_RS23850	COG1126	abc transporter atp-binding protein
FY133_RS23860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY133_RS23865	COG1609	Transcriptional regulator
FY133_RS23900	COG3239	Fatty acid desaturase
FY133_RS23910	COG1278	Cold shock
FY133_RS23990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY133_RS23990	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY133_RS24030	COG4191	Histidine kinase
FY133_RS24045	COG0640	Transcriptional regulator
FY133_RS24075	COG4977	sequence-specific DNA binding
FY133_RS24080	COG2211	Major facilitator Superfamily
FY133_RS24085	COG2807	transmembrane transport
FY133_RS24090	COG1846	Transcriptional regulator
FY133_RS24105	COG2814	Major facilitator Superfamily
FY133_RS24135	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY133_RS24150	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY133_RS24155	COG0583	DNA-binding transcription factor activity
FY133_RS24170	COG0071	Belongs to the small heat shock protein (HSP20) family
FY133_RS24220	COG3838	Conjugal transfer protein Trbc
FY133_RS24225	COG3702	type iv secretory pathway
FY133_RS24230	COG3451	type IV secretory pathway VirB4
FY133_RS24245	COG3704	protein secretion by the type IV secretion system
FY133_RS24255	COG3736	Type IV secretory pathway, component VirB8
FY133_RS24260	COG3504	Conjugal transfer protein
FY133_RS24265	COG2948	multi-organism process
FY133_RS24270	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY133_RS24375	COG3831	ATPase activity
FY133_RS24390	COG3505	Type IV secretory pathway VirD4
FY133_RS24415	COG0583	DNA-binding transcription factor activity
FY133_RS24460	COG0745	RESPONSE REGULATOR receiver
FY133_RS24500	COG3842	ATPase activity
FY133_RS24505	COG4208	sulfate ABC transporter
FY133_RS24510	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS24530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY133_RS24535	COG1942	4-Oxalocrotonate Tautomerase
FY133_RS24545	COG3971	2-oxopent-4-enoate hydratase activity
FY133_RS24555	COG1414	Transcriptional regulator
FY133_RS24565	COG1137	ATPase activity
FY133_RS24580	COG4177	L-phenylalanine transmembrane transporter activity
FY133_RS24600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY133_RS24605	COG1175	transmembrane transport
FY133_RS24610	COG0395	ABC-type sugar transport system, permease component
FY133_RS24620	COG0366	Alpha amylase catalytic
FY133_RS24625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY133_RS24630	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS24635	COG3842	ATPase activity
FY133_RS24645	COG1940	carbohydrate kinase activity
FY133_RS24650	COG0395	ABC-type sugar transport system, permease component
FY133_RS24660	COG2182	Extracellular solute-binding protein
FY133_RS24665	COG0673	inositol 2-dehydrogenase activity
FY133_RS24695	COG1126	abc transporter atp-binding protein
FY133_RS24700	COG0765	amino acid transport
FY133_RS24705	COG0765	amino acid transport
FY133_RS24715	COG4608	Belongs to the ABC transporter superfamily
FY133_RS24725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS24740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY133_RS24745	COG0583	DNA-binding transcription factor activity
FY133_RS24750	COG2423	ornithine cyclodeaminase activity
FY133_RS24760	COG1957	nucleoside hydrolase
FY133_RS24770	COG1309	transcriptional regulator
FY133_RS24780	COG1335	isochorismatase
FY133_RS24785	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS24790	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS24835	COG0583	DNA-binding transcription factor activity
FY133_RS24840	COG1902	pentaerythritol trinitrate reductase activity
FY133_RS24845	COG0583	DNA-binding transcription factor activity
FY133_RS24850	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS24860	COG1335	isochorismatase
FY133_RS24865	COG0583	DNA-binding transcription factor activity
FY133_RS24875	COG1695	Transcriptional regulator
FY133_RS24960	COG2207	Transcriptional regulator
FY133_RS25020	COG1802	Transcriptional regulator
FY133_RS25025	COG3485	protocatechuate 3,4-dioxygenase
FY133_RS25030	COG3971	2-oxopent-4-enoate hydratase activity
FY133_RS25045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY133_RS25050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY133_RS25065	COG1063	alcohol dehydrogenase
FY133_RS25075	COG1960	acyl-CoA dehydrogenase activity
FY133_RS25080	COG1024	Enoyl-CoA hydratase
FY133_RS25090	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS25095	COG0477	Major facilitator Superfamily
FY133_RS25110	COG3706	GGDEF domain
FY133_RS25130	COG1846	Transcriptional regulator
FY133_RS25170	COG1012	belongs to the aldehyde dehydrogenase family
FY133_RS25180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY133_RS25190	COG3386	PFAM SMP-30 Gluconolaconase
FY133_RS25195	COG3622	Belongs to the hyi family
FY133_RS25200	COG2084	Dehydrogenase
FY133_RS25225	COG1940	carbohydrate kinase activity
FY133_RS25230	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS25240	COG1129	ABC transporter
FY133_RS25265	COG0583	DNA-binding transcription factor activity
FY133_RS25270	COG2271	Major facilitator Superfamily
FY133_RS25280	COG2272	Belongs to the type-B carboxylesterase lipase family
FY133_RS25300	COG1129	ABC transporter
FY133_RS25325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY133_RS25335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY133_RS25370	COG0583	DNA-binding transcription factor activity
FY133_RS25375	COG1414	Transcriptional regulator
FY133_RS25385	COG4948	Mandelate Racemase Muconate Lactonizing
FY133_RS25395	COG3842	ATPase activity
FY133_RS25400	COG1175	transmembrane transport
FY133_RS25405	COG0395	ABC-type sugar transport system, permease component
FY133_RS25415	COG0477	Major facilitator Superfamily
FY133_RS25450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY133_RS25465	COG0583	DNA-binding transcription factor activity
FY133_RS25470	COG0747	negative chemotaxis
FY133_RS25480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS25495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS25505	COG4215	(ABC) transporter
FY133_RS25560	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY133_RS25565	COG0251	oxidation-reduction process
FY133_RS25610	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS25615	COG1335	isochorismatase
FY133_RS25625	COG1309	transcriptional regulator
FY133_RS25630	COG4604	ABC transporter, ATP-binding protein
FY133_RS25635	COG4605	iron ion homeostasis
FY133_RS25640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY133_RS25650	COG2132	Multicopper oxidase
FY133_RS25655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY133_RS25710	COG1695	Transcriptional regulator
FY133_RS25745	COG2132	Multicopper oxidase
FY133_RS25755	COG2132	Multicopper oxidase
FY133_RS25790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY133_RS25810	COG1192	Involved in chromosome partitioning
FY133_RS25815	COG1475	DNA binding
FY133_RS25820	COG0640	Transcriptional regulator
FY133_RS25825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY133_RS25855	COG2211	Major facilitator Superfamily
FY133_RS25905	COG1051	belongs to the nudix hydrolase family
FY133_RS25950	COG1475	DNA binding
FY133_RS25975	COG2824	Alkylphosphonate utilization operon protein PhnA
FY133_RS26000	COG1280	lysine exporter protein (LysE YggA)
FY133_RS26015	COG5489	Protein of unknown function (DUF736)
FY133_RS26080	COG1879	ABC-type sugar transport system periplasmic component
FY133_RS26085	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY133_RS26105	COG1280	lysine exporter protein (LysE YggA)
FY133_RS26190	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY133_RS26205	COG0747	negative chemotaxis
FY133_RS26210	COG0444	Belongs to the ABC transporter superfamily
FY133_RS26225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS26230	COG0584	glycerophosphoryl diester phosphodiesterase
FY133_RS26235	COG0483	inositol monophosphate 1-phosphatase activity
FY133_RS26300	COG3161	chorismate lyase activity
FY133_RS26525	COG2222	sugar isomerase
FY133_RS26535	COG0006	proline dipeptidase activity
FY133_RS26555	COG1177	transmembrane transport
FY133_RS26560	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY133_RS26565	COG3842	ATPase activity
FY133_RS26595	COG3842	ATPase activity
FY133_RS26600	COG0006	proline dipeptidase activity
FY133_RS26620	COG0300	oxidoreductase activity
FY133_RS26625	COG0129	dihydroxy-acid dehydratase activity
FY133_RS26630	COG0667	Aldo Keto reductase
FY133_RS26640	COG1028	Short-chain dehydrogenase reductase Sdr
FY133_RS26650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS26655	COG0601	transmembrane transport
FY133_RS26660	COG4172	Belongs to the ABC transporter superfamily
FY133_RS26670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY133_RS26705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS26740	COG3701	Conjugal transfer protein
FY133_RS26745	COG3846	protein secretion by the type IV secretion system
FY133_RS26755	COG5314	conjugation
FY133_RS26760	COG3451	type IV secretory pathway VirB4
FY133_RS26775	COG4962	Type ii secretion system protein e
FY133_RS26785	COG1192	Involved in chromosome partitioning
FY133_RS26790	COG1475	DNA binding
FY133_RS26795	COG0640	Transcriptional regulator
FY133_RS26800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY133_RS26900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY133_RS26915	COG1132	(ABC) transporter
FY133_RS26920	COG4172	Belongs to the ABC transporter superfamily
FY133_RS26925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS26935	COG0747	negative chemotaxis
FY133_RS26945	COG1082	Xylose isomerase domain protein TIM barrel
FY133_RS27015	COG1475	DNA binding
FY133_RS27055	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
FY133_RS27060	COG5489	Protein of unknown function (DUF736)
FY133_RS27140	COG4172	Belongs to the ABC transporter superfamily
FY133_RS27145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS27165	COG2072	flavoprotein involved in K transport
FY133_RS27170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY133_RS27220	COG0584	glycerophosphoryl diester phosphodiesterase
FY133_RS27230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS27245	COG0444	Belongs to the ABC transporter superfamily
FY133_RS27260	COG0747	negative chemotaxis
FY133_RS27280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY133_RS27285	COG0601	transmembrane transport
FY133_RS27300	COG0444	Belongs to the ABC transporter superfamily
FY133_RS27305	COG0747	negative chemotaxis
FY133_RS27315	COG2390	Transcriptional regulator
FY133_RS27360	COG0145	ligase activity
FY133_RS27370	COG0583	DNA-binding transcription factor activity
FY133_RS27415	COG3701	Conjugal transfer protein
FY133_RS27420	COG3846	protein secretion by the type IV secretion system
FY133_RS27430	COG5314	conjugation
FY133_RS27435	COG3451	type IV secretory pathway VirB4
FY133_RS27450	COG4962	Type ii secretion system protein e