locus-tag	class	description
MLE07_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MLE07_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLE07_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MLE07_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MLE07_RS00025	COG1420	regulation of RNA biosynthetic process
MLE07_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MLE07_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLE07_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MLE07_RS00050	COG1137	ATPase activity
MLE07_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MLE07_RS00065	COG0616	signal peptide processing
MLE07_RS00070	COG0776	regulation of translation
MLE07_RS00080	COG0116	Belongs to the methyltransferase superfamily
MLE07_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MLE07_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLE07_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MLE07_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MLE07_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MLE07_RS00115	COG0728	peptidoglycan biosynthetic process
MLE07_RS00125	COG0180	Tryptophanyl-tRNA synthetase
MLE07_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MLE07_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
MLE07_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MLE07_RS00165	COG1702	phosphate starvation-inducible protein PhoH
MLE07_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MLE07_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MLE07_RS00185	COG1396	sequence-specific DNA binding
MLE07_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MLE07_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MLE07_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS00210	COG0242	peptide deformylase activity
MLE07_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MLE07_RS00220	COG0101	tRNA pseudouridine synthase activity
MLE07_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLE07_RS00235	COG2171	N-acyltransferase activity
MLE07_RS00245	COG0840	transmembrane signaling receptor activity
MLE07_RS00250	COG1957	nucleoside hydrolase
MLE07_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
MLE07_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MLE07_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MLE07_RS00295	COG0706	membrane insertase activity
MLE07_RS00300	COG0594	ribonuclease P activity
MLE07_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MLE07_RS00310	COG0840	transmembrane signaling receptor activity
MLE07_RS00325	COG2226	methyltransferase
MLE07_RS00330	COG3842	ATPase activity
MLE07_RS00335	COG1175	transmembrane transport
MLE07_RS00340	COG0395	ABC-type sugar transport system, permease component
MLE07_RS00355	COG0427	acetyl-CoA hydrolase
MLE07_RS00365	COG3938	Belongs to the proline racemase family
MLE07_RS00370	COG0418	dihydroorotase activity
MLE07_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MLE07_RS00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MLE07_RS00400	COG0166	Belongs to the GPI family
MLE07_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
MLE07_RS00410	COG3842	ATPase activity
MLE07_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MLE07_RS00425	COG4774	siderophore transport
MLE07_RS00470	COG2326	polyphosphate kinase activity
MLE07_RS00475	COG5002	protein histidine kinase activity
MLE07_RS00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MLE07_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
MLE07_RS00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MLE07_RS00500	COG0704	Plays a role in the regulation of phosphate uptake
MLE07_RS00505	COG0745	RESPONSE REGULATOR receiver
MLE07_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MLE07_RS00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MLE07_RS00530	COG2967	ApaG domain
MLE07_RS00540	COG0717	Belongs to the dCTP deaminase family
MLE07_RS00625	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MLE07_RS00630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MLE07_RS00680	COG0167	dihydroorotate dehydrogenase activity
MLE07_RS00695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLE07_RS00715	COG1959	2 iron, 2 sulfur cluster binding
MLE07_RS00720	COG1201	RNA secondary structure unwinding
MLE07_RS00750	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS00755	COG0183	Belongs to the thiolase family
MLE07_RS00760	COG1024	Enoyl-CoA hydratase
MLE07_RS00760	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLE07_RS00780	COG1320	monovalent cation:proton antiporter activity
MLE07_RS00785	COG2212	antiporter activity
MLE07_RS00790	COG1863	multisubunit Na H antiporter MnhE subunit
MLE07_RS00795	COG0651	ATP synthesis coupled electron transport
MLE07_RS00800	COG1006	Multisubunit Na H antiporter MnhC subunit
MLE07_RS00805	COG2111	Na H antiporter
MLE07_RS00805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MLE07_RS00815	COG0840	transmembrane signaling receptor activity
MLE07_RS00825	COG0745	RESPONSE REGULATOR receiver
MLE07_RS00830	COG2198	Histidine kinase
MLE07_RS00830	COG0643	Histidine kinase
MLE07_RS00835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MLE07_RS00840	COG2201	protein-glutamate methylesterase activity
MLE07_RS00845	COG0745	RESPONSE REGULATOR receiver
MLE07_RS00850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MLE07_RS00860	COG1766	The M ring may be actively involved in energy transduction
MLE07_RS00865	COG2771	luxR family
MLE07_RS00875	COG2972	Histidine kinase
MLE07_RS00875	COG0840	transmembrane signaling receptor activity
MLE07_RS00880	COG2205	protein histidine kinase activity
MLE07_RS00880	COG0784	Response regulator, receiver
MLE07_RS00880	COG2198	Histidine kinase
MLE07_RS00885	COG1970	mechanosensitive ion channel activity
MLE07_RS00890	COG0436	Aminotransferase
MLE07_RS00905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MLE07_RS00910	COG0424	maF-like protein
MLE07_RS00915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MLE07_RS00925	COG5328	Belongs to the UPF0262 family
MLE07_RS00930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MLE07_RS00940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MLE07_RS00960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MLE07_RS00970	COG1338	Plays a role in the flagellum-specific transport system
MLE07_RS00980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MLE07_RS00990	COG1706	bacterial-type flagellum-dependent cell motility
MLE07_RS00995	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MLE07_RS01000	COG4786	Flagellar basal body rod
MLE07_RS01005	COG1677	Flagellar hook-basal body complex protein FliE
MLE07_RS01010	COG1558	bacterial-type flagellum-dependent cell motility
MLE07_RS01015	COG1815	bacterial-type flagellum-dependent cell motility
MLE07_RS01025	COG1157	protein secretion by the type III secretion system
MLE07_RS01030	COG4786	Flagellar basal body rod
MLE07_RS01040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MLE07_RS01045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLE07_RS01050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLE07_RS01055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLE07_RS01060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MLE07_RS01080	COG1360	Flagellar Motor Protein
MLE07_RS01105	COG1749	Flagellar hook protein flgE
MLE07_RS01125	COG5443	negative regulation of bacterial-type flagellum assembly
MLE07_RS01130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MLE07_RS01140	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MLE07_RS01180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MLE07_RS01185	COG1609	Transcriptional regulator
MLE07_RS01190	COG1653	transport
MLE07_RS01195	COG1175	transmembrane transport
MLE07_RS01200	COG0395	ABC-type sugar transport system, permease component
MLE07_RS01205	COG0366	Alpha amylase catalytic
MLE07_RS01210	COG3842	ATPase activity
MLE07_RS01225	COG0129	dihydroxy-acid dehydratase activity
MLE07_RS01230	COG0363	glucosamine-6-phosphate deaminase activity
MLE07_RS01235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MLE07_RS01245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS01255	COG2081	HI0933 family
MLE07_RS01275	COG2224	Isocitrate lyase
MLE07_RS01290	COG3842	ATPase activity
MLE07_RS01295	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS01300	COG1177	transmembrane transport
MLE07_RS01310	COG2205	protein histidine kinase activity
MLE07_RS01320	COG0248	Ppx GppA phosphatase
MLE07_RS01325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MLE07_RS01330	COG0477	Major facilitator Superfamily
MLE07_RS01360	COG0521	Mo-molybdopterin cofactor biosynthetic process
MLE07_RS01365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MLE07_RS01375	COG0142	geranyltranstransferase activity
MLE07_RS01400	COG0752	glycyl-tRNA synthetase alpha subunit
MLE07_RS01410	COG1704	LemA family
MLE07_RS01415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MLE07_RS01425	COG0751	glycine-tRNA ligase activity
MLE07_RS01430	COG1683	Conserved Protein
MLE07_RS01435	COG0840	transmembrane signaling receptor activity
MLE07_RS01445	COG0151	Belongs to the GarS family
MLE07_RS01450	COG2183	response to ionizing radiation
MLE07_RS01455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MLE07_RS01480	COG0583	DNA-binding transcription factor activity
MLE07_RS01500	COG0306	phosphate transporter
MLE07_RS01510	COG0561	phosphatase activity
MLE07_RS01515	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS01520	COG2186	Transcriptional regulator
MLE07_RS01535	COG0583	DNA-binding transcription factor activity
MLE07_RS01540	COG0277	FAD linked oxidase domain protein
MLE07_RS01545	COG0277	FAD linked oxidase domain protein
MLE07_RS01550	COG0247	lactate metabolic process
MLE07_RS01560	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS01565	COG2818	Glycosylase
MLE07_RS01575	COG2855	membrane
MLE07_RS01580	COG0583	DNA-binding transcription factor activity
MLE07_RS01610	COG0124	histidyl-tRNA synthetase
MLE07_RS01620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MLE07_RS01625	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MLE07_RS01630	COG2259	Doxx family
MLE07_RS01640	COG0459	protein refolding
MLE07_RS01645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MLE07_RS01655	COG0196	riboflavin kinase activity
MLE07_RS01660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MLE07_RS01670	COG0590	tRNA wobble adenosine to inosine editing
MLE07_RS01675	COG1187	pseudouridine synthase activity
MLE07_RS01680	COG0742	ribosomal rna small subunit methyltransferase
MLE07_RS01685	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLE07_RS01695	COG0312	modulator of DNA gyrase
MLE07_RS01700	COG0483	inositol monophosphate 1-phosphatase activity
MLE07_RS01710	COG1519	Transferase
MLE07_RS01720	COG1663	tetraacyldisaccharide 4'-kinase activity
MLE07_RS01730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MLE07_RS01735	COG0745	RESPONSE REGULATOR receiver
MLE07_RS01740	COG3300	MHYT domain
MLE07_RS01740	COG5001	Diguanylate cyclase
MLE07_RS01745	COG3386	PFAM SMP-30 Gluconolaconase
MLE07_RS01750	COG0800	Aldolase
MLE07_RS01755	COG3734	2-keto-3-deoxy-galactonokinase
MLE07_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS01765	COG1414	Transcriptional regulator
MLE07_RS01770	COG2197	response regulator
MLE07_RS01785	COG0598	Magnesium transport protein CorA
MLE07_RS01790	COG3158	transport of potassium into the cell
MLE07_RS01805	COG0356	it plays a direct role in the translocation of protons across the membrane
MLE07_RS01815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MLE07_RS01820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MLE07_RS01835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MLE07_RS01855	COG0009	L-threonylcarbamoyladenylate synthase
MLE07_RS01865	COG4638	Rieske (2fe-2S)
MLE07_RS01890	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS01905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MLE07_RS01910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MLE07_RS01915	COG0840	transmembrane signaling receptor activity
MLE07_RS01925	COG1522	sequence-specific DNA binding
MLE07_RS01950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MLE07_RS01955	COG1741	Belongs to the pirin family
MLE07_RS01960	COG1722	exodeoxyribonuclease VII activity
MLE07_RS01965	COG0123	including yeast histone deacetylase and acetoin utilization protein
MLE07_RS01970	COG1268	BioY protein
MLE07_RS01975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MLE07_RS01980	COG1122	ATPase activity
MLE07_RS01985	COG3214	Protein conserved in bacteria
MLE07_RS01990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MLE07_RS01990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MLE07_RS01995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MLE07_RS02010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MLE07_RS02025	COG0259	pyridoxamine-phosphate oxidase activity
MLE07_RS02045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MLE07_RS02055	COG0312	modulator of DNA gyrase
MLE07_RS02070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MLE07_RS02075	COG0109	protoheme IX farnesyltransferase activity
MLE07_RS02080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MLE07_RS02095	COG3346	SURF1 family
MLE07_RS02100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MLE07_RS02105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MLE07_RS02110	COG0328	RNA-DNA hybrid ribonuclease activity
MLE07_RS02120	COG0678	peroxiredoxin activity
MLE07_RS02120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MLE07_RS02130	COG1678	Uncharacterized ACR, COG1678
MLE07_RS02145	COG3300	MHYT domain
MLE07_RS02145	COG5001	Diguanylate cyclase
MLE07_RS02150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLE07_RS02155	COG0612	Peptidase, M16
MLE07_RS02180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MLE07_RS02185	COG1802	Transcriptional regulator
MLE07_RS02205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MLE07_RS02210	COG3609	addiction module antidote protein, CC2985 family
MLE07_RS02215	COG3668	Plasmid stabilization system
MLE07_RS02225	COG1194	a g-specific adenine glycosylase
MLE07_RS02240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MLE07_RS02245	COG1196	nuclear chromosome segregation
MLE07_RS02250	COG2514	catechol 2,3-dioxygenase activity
MLE07_RS02255	COG0574	Belongs to the PEP-utilizing enzyme family
MLE07_RS02255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MLE07_RS02265	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MLE07_RS02270	COG1823	symporter activity
MLE07_RS02295	COG0579	oxidoreductase
MLE07_RS02315	COG2895	sulfate adenylyltransferase (ATP) activity
MLE07_RS02320	COG0175	sulfate reduction
MLE07_RS02325	COG0175	sulfate reduction
MLE07_RS02330	COG1959	2 iron, 2 sulfur cluster binding
MLE07_RS02335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MLE07_RS02340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MLE07_RS02345	COG4208	sulfate ABC transporter
MLE07_RS02350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MLE07_RS02360	COG2199	diguanylate cyclase activity
MLE07_RS02360	COG2200	EAL domain
MLE07_RS02360	COG2203	Gaf domain
MLE07_RS02370	COG1309	transcriptional regulator
MLE07_RS02375	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS02380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MLE07_RS02410	COG0625	glutathione transferase activity
MLE07_RS02420	COG0477	Major facilitator Superfamily
MLE07_RS02430	COG3657	addiction module killer protein
MLE07_RS02440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MLE07_RS02440	COG1793	dna ligase
MLE07_RS02460	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS02465	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS02470	COG1846	Transcriptional regulator
MLE07_RS02475	COG1764	response to oxidative stress
MLE07_RS02490	COG0488	(ABC) transporter
MLE07_RS02520	COG0583	DNA-binding transcription factor activity
MLE07_RS02525	COG4221	oxidoreductase activity
MLE07_RS02540	COG0433	COG0433 Predicted ATPase
MLE07_RS02550	COG1733	regulation of RNA biosynthetic process
MLE07_RS02555	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MLE07_RS02570	COG0656	L-ascorbic acid biosynthetic process
MLE07_RS02575	COG3781	membrane
MLE07_RS02580	COG2378	regulation of single-species biofilm formation
MLE07_RS02590	COG4106	trans-aconitate 2-methyltransferase activity
MLE07_RS02595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLE07_RS02600	COG0840	transmembrane signaling receptor activity
MLE07_RS02605	COG0583	DNA-binding transcription factor activity
MLE07_RS02620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MLE07_RS02640	COG3909	cytochrome
MLE07_RS02645	COG2010	Cytochrome c
MLE07_RS02680	COG0789	Transcriptional regulator
MLE07_RS02705	COG0517	IMP dehydrogenase activity
MLE07_RS02705	COG4175	Glycine betaine
MLE07_RS02710	COG4176	ABC-type proline glycine betaine transport system permease component
MLE07_RS02730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS02740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MLE07_RS02740	COG2169	Transcriptional regulator
MLE07_RS02750	COG2514	catechol 2,3-dioxygenase activity
MLE07_RS02765	COG1272	protein, Hemolysin III
MLE07_RS02775	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS02780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLE07_RS02785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MLE07_RS02785	COG2111	Na H antiporter
MLE07_RS02790	COG2111	Na H antiporter
MLE07_RS02795	COG1006	Multisubunit Na H antiporter MnhC subunit
MLE07_RS02800	COG0651	ATP synthesis coupled electron transport
MLE07_RS02805	COG1863	multisubunit Na H antiporter MnhE subunit
MLE07_RS02810	COG2212	antiporter activity
MLE07_RS02815	COG1320	monovalent cation:proton antiporter activity
MLE07_RS02820	COG4957	zinc ion binding
MLE07_RS02835	COG2166	iron-sulfur cluster assembly
MLE07_RS02845	COG2205	protein histidine kinase activity
MLE07_RS02890	COG0583	DNA-binding transcription factor activity
MLE07_RS02895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MLE07_RS02900	COG2983	Belongs to the UPF0260 family
MLE07_RS02910	COG3041	Addiction module toxin RelE StbE family
MLE07_RS02915	COG3077	Addiction module antitoxin, RelB DinJ family
MLE07_RS02920	COG2217	Heavy metal translocating P-type atpase
MLE07_RS02950	COG2814	Major facilitator Superfamily
MLE07_RS02960	COG1621	beta-fructofuranosidase activity
MLE07_RS02965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MLE07_RS03015	COG4695	Portal protein
MLE07_RS03120	COG4235	cytochrome complex assembly
MLE07_RS03125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MLE07_RS03130	COG1138	Cytochrome C-type biogenesis protein
MLE07_RS03135	COG3088	subunit of a heme lyase
MLE07_RS03140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLE07_RS03145	COG0745	RESPONSE REGULATOR receiver
MLE07_RS03150	COG2205	protein histidine kinase activity
MLE07_RS03155	COG3011	Protein conserved in bacteria
MLE07_RS03160	COG3713	MltA-interacting MipA family protein
MLE07_RS03165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MLE07_RS03170	COG2205	protein histidine kinase activity
MLE07_RS03170	COG2202	Pas domain
MLE07_RS03180	COG0308	aminopeptidase N
MLE07_RS03185	COG0697	spore germination
MLE07_RS03200	COG0443	Heat shock 70 kDa protein
MLE07_RS03235	COG0604	alcohol dehydrogenase
MLE07_RS03240	COG1733	regulation of RNA biosynthetic process
MLE07_RS03245	COG1968	undecaprenyl-diphosphatase activity
MLE07_RS03250	COG2239	Acts as a magnesium transporter
MLE07_RS03255	COG2814	Major facilitator Superfamily
MLE07_RS03285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MLE07_RS03315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MLE07_RS03365	COG0741	lytic transglycosylase activity
MLE07_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS03375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MLE07_RS03380	COG0840	transmembrane signaling receptor activity
MLE07_RS03390	COG1758	RNA polymerase activity
MLE07_RS03415	COG0736	holo-[acyl-carrier-protein] synthase activity
MLE07_RS03420	COG0681	Belongs to the peptidase S26 family
MLE07_RS03425	COG0571	ribonuclease III activity
MLE07_RS03430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MLE07_RS03440	COG0784	Response regulator, receiver
MLE07_RS03445	COG1381	Involved in DNA repair and RecF pathway recombination
MLE07_RS03455	COG2226	methyltransferase
MLE07_RS03465	COG1418	mRNA catabolic process
MLE07_RS03475	COG0346	lactoylglutathione lyase activity
MLE07_RS03490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS03495	COG3443	Belongs to the bacterial solute-binding protein 9 family
MLE07_RS03500	COG0668	transmembrane transport
MLE07_RS03510	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MLE07_RS03540	COG1742	UPF0060 membrane protein
MLE07_RS03555	COG1183	phosphatidylcholine synthase activity
MLE07_RS03560	COG0688	phosphatidylethanolamine metabolic process
MLE07_RS03565	COG5265	(ABC) transporter
MLE07_RS03605	COG2852	Protein conserved in bacteria
MLE07_RS03615	COG0215	cysteine-tRNA ligase activity
MLE07_RS03620	COG4221	oxidoreductase activity
MLE07_RS03625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MLE07_RS03630	COG1286	toxin biosynthetic process
MLE07_RS03650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MLE07_RS03660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MLE07_RS03670	COG0305	Participates in initiation and elongation during chromosome replication
MLE07_RS03690	COG0359	binds to the 23S rRNA
MLE07_RS03700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MLE07_RS03705	COG0360	Binds together with S18 to 16S ribosomal RNA
MLE07_RS03715	COG0667	Aldo Keto reductase
MLE07_RS03720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MLE07_RS03730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLE07_RS03735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MLE07_RS03745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MLE07_RS03750	COG1561	YicC-like family, N-terminal region
MLE07_RS03755	COG0194	GDP metabolic process
MLE07_RS03760	COG0400	carboxylic ester hydrolase activity
MLE07_RS03765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MLE07_RS03770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MLE07_RS03780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MLE07_RS03795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MLE07_RS03815	COG4251	negative regulation of phosphorylation
MLE07_RS03815	COG3706	GGDEF domain
MLE07_RS03815	COG5001	Diguanylate cyclase
MLE07_RS03815	COG2203	Gaf domain
MLE07_RS03820	COG3300	MHYT domain
MLE07_RS03820	COG5001	Diguanylate cyclase
MLE07_RS03825	COG4191	Histidine kinase
MLE07_RS03830	COG4566	intracellular signal transduction
MLE07_RS03840	COG0488	(ABC) transporter
MLE07_RS03845	COG3706	GGDEF domain
MLE07_RS03855	COG0105	UTP biosynthetic process
MLE07_RS03875	COG0314	molybdopterin synthase activity
MLE07_RS03885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MLE07_RS03890	COG0322	excinuclease ABC activity
MLE07_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS03910	COG3719	Belongs to the RNase T2 family
MLE07_RS03920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MLE07_RS03925	COG0243	molybdopterin cofactor binding
MLE07_RS03940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MLE07_RS03945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MLE07_RS03955	COG0628	permease
MLE07_RS03965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MLE07_RS03970	COG0248	Ppx GppA phosphatase
MLE07_RS03975	COG0110	maltose O-acetyltransferase activity
MLE07_RS03995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MLE07_RS04005	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MLE07_RS04010	COG0477	Major facilitator Superfamily
MLE07_RS04015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MLE07_RS04025	COG0840	transmembrane signaling receptor activity
MLE07_RS04030	COG0659	secondary active sulfate transmembrane transporter activity
MLE07_RS04040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MLE07_RS04045	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MLE07_RS04055	COG0113	porphobilinogen synthase activity
MLE07_RS04075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MLE07_RS04080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MLE07_RS04085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLE07_RS04085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLE07_RS04095	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS04100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MLE07_RS04105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MLE07_RS04110	COG2814	Major facilitator Superfamily
MLE07_RS04115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MLE07_RS04135	COG0416	fatty acid biosynthetic process
MLE07_RS04140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLE07_RS04145	COG0776	regulation of translation
MLE07_RS04180	COG0601	transmembrane transport
MLE07_RS04185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS04190	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS04200	COG0747	negative chemotaxis
MLE07_RS04210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MLE07_RS04215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MLE07_RS04230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MLE07_RS04235	COG0583	DNA-binding transcription factor activity
MLE07_RS04240	COG0737	Belongs to the 5'-nucleotidase family
MLE07_RS04260	COG2897	thiosulfate sulfurtransferase activity
MLE07_RS04275	COG0415	Belongs to the DNA photolyase family
MLE07_RS04285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MLE07_RS04315	COG3932	Exopolysaccharide synthesis, ExoD
MLE07_RS04320	COG1238	metal cluster binding
MLE07_RS04395	COG1612	heme a metabolic process
MLE07_RS04405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MLE07_RS04410	COG0010	Belongs to the arginase family
MLE07_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MLE07_RS04420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MLE07_RS04430	COG1832	CoA-binding protein
MLE07_RS04440	COG1846	Transcriptional regulator
MLE07_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS04475	COG2199	diguanylate cyclase activity
MLE07_RS04480	COG0740	serine-type endopeptidase activity
MLE07_RS04485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MLE07_RS04490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MLE07_RS04500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MLE07_RS04530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLE07_RS04535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLE07_RS04540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLE07_RS04550	COG0649	NAD binding
MLE07_RS04560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MLE07_RS04565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MLE07_RS04575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MLE07_RS04580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLE07_RS04590	COG0713	ATP synthesis coupled electron transport
MLE07_RS04605	COG1007	ATP synthesis coupled electron transport
MLE07_RS04610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MLE07_RS04610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MLE07_RS04625	COG0442	prolyl-tRNA aminoacylation
MLE07_RS04635	COG1136	(ABC) transporter
MLE07_RS04650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MLE07_RS04670	COG0784	Response regulator, receiver
MLE07_RS04680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MLE07_RS04685	COG0477	Major facilitator Superfamily
MLE07_RS04700	COG0557	exoribonuclease II activity
MLE07_RS04705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MLE07_RS04715	COG0758	DNA mediated transformation
MLE07_RS04720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MLE07_RS04730	COG0540	Belongs to the ATCase OTCase family
MLE07_RS04745	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS04750	COG0456	acetyltransferase
MLE07_RS04770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MLE07_RS04775	COG2824	Alkylphosphonate utilization operon protein PhnA
MLE07_RS04780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MLE07_RS04785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MLE07_RS04790	COG0154	amidase activity
MLE07_RS04795	COG0456	acetyltransferase
MLE07_RS04800	COG3811	Belongs to the UPF0386 family
MLE07_RS04815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MLE07_RS04845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MLE07_RS04850	COG0439	Biotin carboxylase
MLE07_RS04855	COG0511	ligase activity, forming carbon-carbon bonds
MLE07_RS04860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MLE07_RS04870	COG0436	Aminotransferase
MLE07_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS04895	COG1530	ribonuclease E activity
MLE07_RS04905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MLE07_RS04925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MLE07_RS04930	COG0384	phenazine biosynthesis protein PhzF
MLE07_RS04950	COG0633	Ferredoxin
MLE07_RS04960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MLE07_RS04965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MLE07_RS04970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MLE07_RS04980	COG3768	UPF0283 membrane protein
MLE07_RS04985	COG3106	COG3106 Predicted ATPase
MLE07_RS05015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MLE07_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
MLE07_RS05070	COG0052	Belongs to the universal ribosomal protein uS2 family
MLE07_RS05075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MLE07_RS05080	COG0528	UMP kinase activity
MLE07_RS05085	COG0233	cytoplasmic translational termination
MLE07_RS05090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MLE07_RS05100	COG0750	zinc metalloprotease
MLE07_RS05105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLE07_RS05110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLE07_RS05115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLE07_RS05120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLE07_RS05125	COG3494	Protein of unknown function (DUF1009)
MLE07_RS05130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MLE07_RS05135	COG2186	Transcriptional regulator
MLE07_RS05145	COG0765	amino acid transport
MLE07_RS05150	COG0765	amino acid transport
MLE07_RS05160	COG0372	Belongs to the citrate synthase family
MLE07_RS05175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MLE07_RS05185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MLE07_RS05190	COG0148	phosphopyruvate hydratase activity
MLE07_RS05200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MLE07_RS05205	COG0022	dehydrogenase e1 component
MLE07_RS05205	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLE07_RS05215	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLE07_RS05225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLE07_RS05235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MLE07_RS05240	COG0697	spore germination
MLE07_RS05260	COG2867	negative regulation of translational initiation
MLE07_RS05265	COG1546	Belongs to the CinA family
MLE07_RS05270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MLE07_RS05270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MLE07_RS05280	COG3852	Histidine kinase
MLE07_RS05285	COG2204	response regulator
MLE07_RS05290	COG5000	phosphorelay sensor kinase activity
MLE07_RS05295	COG2204	response regulator
MLE07_RS05300	COG0569	domain protein
MLE07_RS05305	COG1923	regulation of RNA biosynthetic process
MLE07_RS05310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MLE07_RS05315	COG3956	TIGRFAM MazG family protein
MLE07_RS05325	COG1648	precorrin-2 dehydrogenase activity
MLE07_RS05325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MLE07_RS05365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MLE07_RS05365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MLE07_RS05370	COG0509	glycine decarboxylation via glycine cleavage system
MLE07_RS05375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS05400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MLE07_RS05405	COG0564	pseudouridine synthase activity
MLE07_RS05425	COG0251	oxidation-reduction process
MLE07_RS05430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MLE07_RS05440	COG1671	Belongs to the UPF0178 family
MLE07_RS05455	COG0450	alkyl hydroperoxide reductase
MLE07_RS05465	COG0625	glutathione transferase activity
MLE07_RS05500	COG0431	NADPH-dependent FMN reductase
MLE07_RS05510	COG0798	PFAM Bile acid sodium symporter
MLE07_RS05515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLE07_RS05530	COG0321	lipoyl(octanoyl) transferase activity
MLE07_RS05530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MLE07_RS05535	COG0084	hydrolase, TatD family'
MLE07_RS05540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLE07_RS05550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MLE07_RS05605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MLE07_RS05610	COG2095	MarC family integral membrane protein
MLE07_RS05615	COG0517	IMP dehydrogenase activity
MLE07_RS05615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MLE07_RS05615	COG0617	tRNA 3'-terminal CCA addition
MLE07_RS05625	COG0629	single-stranded DNA binding
MLE07_RS05630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MLE07_RS05640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MLE07_RS05660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLE07_RS05665	COG1121	(ABC) transporter
MLE07_RS05685	COG0667	Aldo Keto reductase
MLE07_RS05695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MLE07_RS05775	COG2239	Acts as a magnesium transporter
MLE07_RS05780	COG0243	molybdopterin cofactor binding
MLE07_RS05790	COG0242	peptide deformylase activity
MLE07_RS05805	COG2202	Pas domain
MLE07_RS05805	COG2205	protein histidine kinase activity
MLE07_RS05815	COG0321	lipoyl(octanoyl) transferase activity
MLE07_RS05820	COG1064	alcohol dehydrogenase
MLE07_RS05850	COG1862	Preprotein translocase
MLE07_RS05870	COG2124	cytochrome p450
MLE07_RS05885	COG0596	Alpha beta hydrolase
MLE07_RS05900	COG0626	cystathionine gamma-synthase activity
MLE07_RS05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS05910	COG4597	amino acid ABC transporter
MLE07_RS05915	COG0765	amino acid transport
MLE07_RS05920	COG1126	abc transporter atp-binding protein
MLE07_RS05935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MLE07_RS05950	COG0436	Aminotransferase
MLE07_RS05980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MLE07_RS05990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLE07_RS05995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLE07_RS06000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLE07_RS06015	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLE07_RS06020	COG1489	DNA binding
MLE07_RS06025	COG0024	Methionine aminopeptidase
MLE07_RS06030	COG2003	Belongs to the UPF0758 family
MLE07_RS06045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MLE07_RS06070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MLE07_RS06075	COG0546	phosphoglycolate phosphatase activity
MLE07_RS06085	COG0114	fumarate hydratase activity
MLE07_RS06095	COG0504	CTP synthase activity
MLE07_RS06105	COG0149	triose-phosphate isomerase activity
MLE07_RS06115	COG0187	DNA topoisomerase II activity
MLE07_RS06125	COG0740	serine-type endopeptidase activity
MLE07_RS06135	COG0640	Transcriptional regulator
MLE07_RS06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLE07_RS06145	COG0745	RESPONSE REGULATOR receiver
MLE07_RS06165	COG3264	Mechanosensitive ion channel
MLE07_RS06165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MLE07_RS06230	COG1127	ABC transporter
MLE07_RS06235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MLE07_RS06240	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS06250	COG0280	phosphate acetyltransferase
MLE07_RS06250	COG0281	malic enzyme
MLE07_RS06260	COG0778	Nitroreductase
MLE07_RS06265	COG0823	Involved in the tonB-independent uptake of proteins
MLE07_RS06280	COG1368	sulfuric ester hydrolase activity
MLE07_RS06305	COG0544	peptidyl-prolyl cis-trans isomerase activity
MLE07_RS06325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MLE07_RS06345	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MLE07_RS06360	COG0318	PFAM AMP-dependent synthetase and ligase
MLE07_RS06370	COG0512	Glutamine amidotransferase of anthranilate synthase
MLE07_RS06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MLE07_RS06375	COG0343	queuine tRNA-ribosyltransferase activity
MLE07_RS06380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MLE07_RS06395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MLE07_RS06410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MLE07_RS06415	COG0134	indole-3-glycerol-phosphate synthase activity
MLE07_RS06420	COG0315	cyclic pyranopterin monophosphate synthase activity
MLE07_RS06425	COG0303	'Molybdopterin
MLE07_RS06430	COG3706	GGDEF domain
MLE07_RS06440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MLE07_RS06440	COG0475	glutathione-regulated potassium exporter activity
MLE07_RS06450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MLE07_RS06460	COG2814	Major facilitator Superfamily
MLE07_RS06465	COG0746	molybdenum cofactor guanylyltransferase activity
MLE07_RS06470	COG1763	Mo-molybdopterin cofactor biosynthetic process
MLE07_RS06475	COG0739	heme binding
MLE07_RS06480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MLE07_RS06485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MLE07_RS06490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MLE07_RS06495	COG0805	protein transport
MLE07_RS06500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MLE07_RS06505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MLE07_RS06510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MLE07_RS06515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MLE07_RS06520	COG1472	Belongs to the glycosyl hydrolase 3 family
MLE07_RS06530	COG0018	arginyl-trna synthetase
MLE07_RS06535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MLE07_RS06560	COG0525	valine-tRNA ligase activity
MLE07_RS06570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MLE07_RS06600	COG0655	NAD(P)H dehydrogenase (quinone) activity
MLE07_RS06605	COG1058	Belongs to the CinA family
MLE07_RS06605	COG1546	Belongs to the CinA family
MLE07_RS06610	COG0589	response to stress
MLE07_RS06615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MLE07_RS06625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MLE07_RS06635	COG0640	Transcriptional regulator
MLE07_RS06640	COG1914	H( )-stimulated, divalent metal cation uptake system
MLE07_RS06650	COG1132	(ABC) transporter
MLE07_RS06655	COG0628	permease
MLE07_RS06690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MLE07_RS06700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MLE07_RS06710	COG0302	gtp cyclohydrolase
MLE07_RS06715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MLE07_RS06720	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLE07_RS06730	COG0516	GMP reductase activity
MLE07_RS06730	COG0517	IMP dehydrogenase activity
MLE07_RS06765	COG1760	l-serine dehydratase
MLE07_RS06805	COG0583	DNA-binding transcription factor activity
MLE07_RS06820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MLE07_RS06820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MLE07_RS06830	COG0347	Belongs to the P(II) protein family
MLE07_RS06835	COG0174	glutamine synthetase
MLE07_RS06865	COG0697	spore germination
MLE07_RS06875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MLE07_RS06885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MLE07_RS06915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MLE07_RS06920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MLE07_RS06925	COG2186	Transcriptional regulator
MLE07_RS06935	COG1079	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS06940	COG4603	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS06945	COG3845	ABC transporter
MLE07_RS06950	COG1183	phosphatidylcholine synthase activity
MLE07_RS06955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLE07_RS06960	COG0679	Auxin Efflux Carrier
MLE07_RS06965	COG0785	Cytochrome C biogenesis protein
MLE07_RS06990	COG1278	Cold shock
MLE07_RS07040	COG0577	efflux transmembrane transporter activity
MLE07_RS07040	COG1136	(ABC) transporter
MLE07_RS07045	COG0577	efflux transmembrane transporter activity
MLE07_RS07045	COG1136	(ABC) transporter
MLE07_RS07070	COG2151	metal-sulfur cluster biosynthetic enzyme
MLE07_RS07075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MLE07_RS07080	COG0719	Fe-S assembly protein
MLE07_RS07085	COG0396	ATPase activity
MLE07_RS07090	COG0719	Fe-S assembly protein
MLE07_RS07095	COG1104	cysteine desulfurase activity
MLE07_RS07100	COG2945	thiolester hydrolase activity
MLE07_RS07105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MLE07_RS07110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MLE07_RS07120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MLE07_RS07125	COG2833	Protein of unknown function (DUF455)
MLE07_RS07130	COG0739	heme binding
MLE07_RS07135	COG0513	Belongs to the DEAD box helicase family
MLE07_RS07160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MLE07_RS07170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MLE07_RS07175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MLE07_RS07180	COG0047	phosphoribosylformylglycinamidine synthase activity
MLE07_RS07195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLE07_RS07200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MLE07_RS07220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MLE07_RS07225	COG2814	Major facilitator Superfamily
MLE07_RS07230	COG0483	inositol monophosphate 1-phosphatase activity
MLE07_RS07235	COG0483	inositol monophosphate 1-phosphatase activity
MLE07_RS07240	COG0037	tRNA processing
MLE07_RS07245	COG2066	Belongs to the glutaminase family
MLE07_RS07250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MLE07_RS07255	COG0861	Integral membrane protein TerC family
MLE07_RS07270	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS07280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MLE07_RS07285	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MLE07_RS07295	COG0538	isocitrate dehydrogenase activity
MLE07_RS07305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MLE07_RS07310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MLE07_RS07315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS07320	COG2313	pseudouridylate synthase activity
MLE07_RS07330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS07335	COG4215	(ABC) transporter
MLE07_RS07345	COG5425	PFAM Usg family protein
MLE07_RS07355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLE07_RS07360	COG1522	sequence-specific DNA binding
MLE07_RS07365	COG1573	uracil-dna glycosylase
MLE07_RS07375	COG2202	Pas domain
MLE07_RS07375	COG2205	protein histidine kinase activity
MLE07_RS07385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MLE07_RS07390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MLE07_RS07405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MLE07_RS07410	COG0842	Transport permease protein
MLE07_RS07415	COG1131	(ABC) transporter
MLE07_RS07420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLE07_RS07420	COG0730	response to heat
MLE07_RS07440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MLE07_RS07445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLE07_RS07465	COG0129	dihydroxy-acid dehydratase activity
MLE07_RS07470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MLE07_RS07475	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MLE07_RS07485	COG3739	integral membrane protein
MLE07_RS07490	COG0203	ribosomal protein L17
MLE07_RS07495	COG0202	RNA polymerase activity
MLE07_RS07500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MLE07_RS07505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MLE07_RS07510	COG0563	adenylate kinase activity
MLE07_RS07515	COG0201	protein transport
MLE07_RS07520	COG0200	Binds to the 23S rRNA
MLE07_RS07525	COG1841	ribosomal large subunit assembly
MLE07_RS07530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MLE07_RS07535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MLE07_RS07540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MLE07_RS07545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MLE07_RS07550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MLE07_RS07555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MLE07_RS07560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MLE07_RS07565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MLE07_RS07570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MLE07_RS07575	COG0255	Belongs to the universal ribosomal protein uL29 family
MLE07_RS07580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MLE07_RS07585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MLE07_RS07590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MLE07_RS07595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MLE07_RS07600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MLE07_RS07605	COG0089	rRNA binding
MLE07_RS07610	COG0088	Forms part of the polypeptide exit tunnel
MLE07_RS07615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MLE07_RS07620	COG0051	transcription antitermination factor activity, RNA binding
MLE07_RS07625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MLE07_RS07630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MLE07_RS07635	COG0049	tRNA binding
MLE07_RS07640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MLE07_RS07655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MLE07_RS07660	COG0085	RNA polymerase activity
MLE07_RS07665	COG0222	ribosome binding
MLE07_RS07670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MLE07_RS07675	COG0081	regulation of translation
MLE07_RS07680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MLE07_RS07690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MLE07_RS07700	COG1086	Polysaccharide biosynthesis protein
MLE07_RS07705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MLE07_RS07710	COG0861	Integral membrane protein TerC family
MLE07_RS07715	COG3895	Periplasmic Protein
MLE07_RS07735	COG1132	(ABC) transporter
MLE07_RS07750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLE07_RS07755	COG1607	acyl-coa hydrolase
MLE07_RS07775	COG2910	NAD(P)H-binding
MLE07_RS07780	COG1733	regulation of RNA biosynthetic process
MLE07_RS07795	COG0556	nucleotide-excision repair
MLE07_RS07800	COG2382	esterase
MLE07_RS07820	COG0484	heat shock protein binding
MLE07_RS07955	COG0328	RNA-DNA hybrid ribonuclease activity
MLE07_RS08025	COG3706	GGDEF domain
MLE07_RS08045	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS08050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLE07_RS08065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MLE07_RS08075	COG2207	Transcriptional regulator
MLE07_RS08080	COG1064	alcohol dehydrogenase
MLE07_RS08085	COG1252	NADH dehydrogenase
MLE07_RS08090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MLE07_RS08095	COG2197	response regulator
MLE07_RS08100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLE07_RS08135	COG0656	L-ascorbic acid biosynthetic process
MLE07_RS08150	COG0440	acetolactate synthase activity
MLE07_RS08155	COG0028	Belongs to the TPP enzyme family
MLE07_RS08170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MLE07_RS08175	COG0560	Phosphoserine phosphatase
MLE07_RS08175	COG3830	Belongs to the UPF0237 family
MLE07_RS08195	COG0330	HflC and HflK could
MLE07_RS08200	COG0330	HflC and HflK could
MLE07_RS08210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MLE07_RS08245	COG0277	FAD linked oxidase domain protein
MLE07_RS08250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLE07_RS08290	COG1335	isochorismatase
MLE07_RS08320	COG2264	protein methyltransferase activity
MLE07_RS08325	COG1999	signal sequence binding
MLE07_RS08335	COG0835	chemotaxis
MLE07_RS08345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MLE07_RS08350	COG0583	DNA-binding transcription factor activity
MLE07_RS08360	COG1247	-acetyltransferase
MLE07_RS08370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MLE07_RS08375	COG0497	DNA recombination
MLE07_RS08380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLE07_RS08390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MLE07_RS08395	COG0849	cell division
MLE07_RS08400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MLE07_RS08405	COG1181	Belongs to the D-alanine--D-alanine ligase family
MLE07_RS08410	COG0477	Major facilitator Superfamily
MLE07_RS08415	COG5001	Diguanylate cyclase
MLE07_RS08420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MLE07_RS08425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MLE07_RS08430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MLE07_RS08440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MLE07_RS08445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MLE07_RS08455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MLE07_RS08470	COG0275	rRNA processing
MLE07_RS08475	COG2001	Belongs to the MraZ family
MLE07_RS08500	COG3023	N-Acetylmuramoyl-L-alanine amidase
MLE07_RS08530	COG4106	trans-aconitate 2-methyltransferase activity
MLE07_RS08550	COG2226	methyltransferase
MLE07_RS08560	COG2267	carboxylic ester hydrolase activity
MLE07_RS08565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MLE07_RS08580	COG0251	oxidation-reduction process
MLE07_RS08595	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS08625	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS08630	COG0174	glutamine synthetase
MLE07_RS08635	COG0531	amino acid
MLE07_RS08645	COG1737	Transcriptional regulator
MLE07_RS08650	COG2182	Extracellular solute-binding protein
MLE07_RS08665	COG3842	ATPase activity
MLE07_RS08755	COG2801	Transposase and inactivated derivatives
MLE07_RS08860	COG4373	Mu-like prophage FluMu protein gp28
MLE07_RS08985	COG1122	ATPase activity
MLE07_RS09005	COG2968	Membrane
MLE07_RS09015	COG0432	Pfam Uncharacterised protein family UPF0047
MLE07_RS09030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MLE07_RS09035	COG0358	DNA primase activity
MLE07_RS09055	COG0505	Belongs to the CarA family
MLE07_RS09060	COG0534	Mate efflux family protein
MLE07_RS09075	COG2321	neutral zinc metallopeptidase
MLE07_RS09090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MLE07_RS09100	COG3706	GGDEF domain
MLE07_RS09115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MLE07_RS09125	COG1522	sequence-specific DNA binding
MLE07_RS09130	COG0492	ferredoxin-NADP+ reductase activity
MLE07_RS09135	COG0583	DNA-binding transcription factor activity
MLE07_RS09145	COG1902	pentaerythritol trinitrate reductase activity
MLE07_RS09170	COG0387	Pfam Sodium calcium exchanger
MLE07_RS09175	COG0436	Aminotransferase
MLE07_RS09180	COG2199	diguanylate cyclase activity
MLE07_RS09180	COG2200	EAL domain
MLE07_RS09195	COG1278	Cold shock
MLE07_RS09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLE07_RS09210	COG1846	Transcriptional regulator
MLE07_RS09215	COG0745	RESPONSE REGULATOR receiver
MLE07_RS09220	COG2205	protein histidine kinase activity
MLE07_RS09225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLE07_RS09245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MLE07_RS09255	COG1496	oxidoreductase activity
MLE07_RS09270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MLE07_RS09280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MLE07_RS09295	COG0840	transmembrane signaling receptor activity
MLE07_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS09305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MLE07_RS09310	COG5001	Diguanylate cyclase
MLE07_RS09310	COG3300	MHYT domain
MLE07_RS09315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MLE07_RS09320	COG5001	Diguanylate cyclase
MLE07_RS09330	COG0193	aminoacyl-tRNA hydrolase activity
MLE07_RS09340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MLE07_RS09365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MLE07_RS09375	COG2857	Cytochrome c1
MLE07_RS09375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MLE07_RS09395	COG1132	(ABC) transporter
MLE07_RS09405	COG1132	(ABC) transporter
MLE07_RS09415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MLE07_RS09430	COG0408	coproporphyrinogen oxidase activity
MLE07_RS09445	COG0617	tRNA 3'-terminal CCA addition
MLE07_RS09460	COG0714	Associated with various cellular activities
MLE07_RS09480	COG0454	-acetyltransferase
MLE07_RS09495	COG0477	Major facilitator Superfamily
MLE07_RS09505	COG0435	Glutathione S-transferase
MLE07_RS09510	COG0494	nUDIX hydrolase
MLE07_RS09520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MLE07_RS09525	COG3135	benzoate transporter
MLE07_RS09550	COG0740	serine-type endopeptidase activity
MLE07_RS09565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MLE07_RS09570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MLE07_RS09595	COG4175	Glycine betaine
MLE07_RS09615	COG1435	thymidine kinase activity
MLE07_RS09640	COG1629	transport
MLE07_RS09640	COG4771	TonB-dependent receptor
MLE07_RS09650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MLE07_RS09650	COG0512	Glutamine amidotransferase of anthranilate synthase
MLE07_RS09665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MLE07_RS09675	COG0366	Alpha amylase catalytic
MLE07_RS09680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS09700	COG1160	GTP binding
MLE07_RS09720	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MLE07_RS09730	COG0024	Methionine aminopeptidase
MLE07_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS09760	COG0583	DNA-binding transcription factor activity
MLE07_RS09775	COG0402	S-adenosylhomocysteine deaminase activity
MLE07_RS09785	COG1304	FMN binding
MLE07_RS09795	COG1309	transcriptional regulator
MLE07_RS09800	COG1686	Belongs to the peptidase S11 family
MLE07_RS09810	COG2351	hydroxyisourate hydrolase activity
MLE07_RS09815	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MLE07_RS09840	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MLE07_RS09850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MLE07_RS09850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS09860	COG0513	Belongs to the DEAD box helicase family
MLE07_RS09870	COG2259	Doxx family
MLE07_RS09875	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS09885	COG2308	Evidence 4 Homologs of previously reported genes of
MLE07_RS09895	COG1305	Transglutaminase-like
MLE07_RS09915	COG0588	phosphoglycerate mutase activity
MLE07_RS09925	COG4214	carbohydrate transport
MLE07_RS09935	COG4213	ABC transporter substrate-binding protein
MLE07_RS09970	COG0840	transmembrane signaling receptor activity
MLE07_RS09985	COG1410	methionine synthase
MLE07_RS09985	COG0646	methionine synthase
MLE07_RS10030	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS10060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MLE07_RS10065	COG2346	COG2346, Truncated hemoglobins
MLE07_RS10085	COG1309	transcriptional regulator
MLE07_RS10100	COG0494	nUDIX hydrolase
MLE07_RS10110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS10145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MLE07_RS10150	COG0830	nickel cation binding
MLE07_RS10155	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MLE07_RS10170	COG0804	urea catabolic process
MLE07_RS10175	COG1442	glycosyl transferase family 8
MLE07_RS10180	COG3755	Protein conserved in bacteria
MLE07_RS10190	COG0832	Belongs to the urease beta subunit family
MLE07_RS10195	COG3813	Protein conserved in bacteria
MLE07_RS10200	COG0831	urea catabolic process
MLE07_RS10205	COG0829	nickel cation binding
MLE07_RS10235	COG0559	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS10250	COG0174	glutamine synthetase
MLE07_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS10260	COG2198	Histidine kinase
MLE07_RS10260	COG0784	Response regulator, receiver
MLE07_RS10260	COG5002	protein histidine kinase activity
MLE07_RS10275	COG0726	polysaccharide deacetylase
MLE07_RS10310	COG1218	3'(2'),5'-bisphosphate nucleotidase
MLE07_RS10385	COG0564	pseudouridine synthase activity
MLE07_RS10395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MLE07_RS10405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MLE07_RS10430	COG0346	lactoylglutathione lyase activity
MLE07_RS10440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MLE07_RS10450	COG2832	Protein of unknown function (DUF454)
MLE07_RS10455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MLE07_RS10460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS10465	COG4558	Periplasmic binding protein
MLE07_RS10475	COG3721	Heme iron utilization protein
MLE07_RS10495	COG2205	protein histidine kinase activity
MLE07_RS10535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS10540	COG4605	iron ion homeostasis
MLE07_RS10545	COG4604	ABC transporter, ATP-binding protein
MLE07_RS10550	COG0783	Belongs to the Dps family
MLE07_RS10565	COG2972	Histidine kinase
MLE07_RS10565	COG0840	transmembrane signaling receptor activity
MLE07_RS10570	COG0656	L-ascorbic acid biosynthetic process
MLE07_RS10575	COG2814	Major facilitator Superfamily
MLE07_RS10585	COG0583	DNA-binding transcription factor activity
MLE07_RS10590	COG0657	acetylesterase activity
MLE07_RS10595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS10615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLE07_RS10620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MLE07_RS10625	COG0288	reversible hydration of carbon dioxide
MLE07_RS10635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MLE07_RS10655	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MLE07_RS10660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MLE07_RS10665	COG0778	Nitroreductase
MLE07_RS10670	COG2267	carboxylic ester hydrolase activity
MLE07_RS10675	COG0251	oxidation-reduction process
MLE07_RS10680	COG1335	isochorismatase
MLE07_RS10685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS10695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS10710	COG1175	transmembrane transport
MLE07_RS10715	COG0395	ABC-type sugar transport system, permease component
MLE07_RS10720	COG3842	ATPase activity
MLE07_RS10725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS10735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLE07_RS10750	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS10755	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS10760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS10765	COG0601	transmembrane transport
MLE07_RS10820	COG2159	amidohydrolase
MLE07_RS10825	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS10855	COG0745	RESPONSE REGULATOR receiver
MLE07_RS10865	COG1902	pentaerythritol trinitrate reductase activity
MLE07_RS10865	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS10870	COG3842	ATPase activity
MLE07_RS10880	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS10885	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS10890	COG0745	RESPONSE REGULATOR receiver
MLE07_RS10900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MLE07_RS10905	COG0583	DNA-binding transcription factor activity
MLE07_RS10910	COG1278	Cold shock
MLE07_RS10945	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
MLE07_RS10945	COG3210	domain, Protein
MLE07_RS10945	COG3064	Membrane
MLE07_RS10975	COG1126	abc transporter atp-binding protein
MLE07_RS10985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS10990	COG1609	Transcriptional regulator
MLE07_RS11000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS11005	COG0477	Major facilitator Superfamily
MLE07_RS11010	COG0693	protein deglycase activity
MLE07_RS11015	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS11025	COG1129	ABC transporter
MLE07_RS11030	COG1802	Transcriptional regulator
MLE07_RS11035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MLE07_RS11040	COG1454	alcohol dehydrogenase
MLE07_RS11050	COG0657	acetylesterase activity
MLE07_RS11085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLE07_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS11105	COG4191	Histidine kinase
MLE07_RS11110	COG4566	intracellular signal transduction
MLE07_RS11115	COG2204	response regulator
MLE07_RS11120	COG4566	intracellular signal transduction
MLE07_RS11125	COG0583	DNA-binding transcription factor activity
MLE07_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS11135	COG0656	L-ascorbic acid biosynthetic process
MLE07_RS11140	COG0667	Aldo Keto reductase
MLE07_RS11210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MLE07_RS11215	COG1309	transcriptional regulator
MLE07_RS11220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS11225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLE07_RS11235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MLE07_RS11240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MLE07_RS11260	COG0583	DNA-binding transcription factor activity
MLE07_RS11265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS11270	COG0725	ABC transporter, periplasmic molybdate-binding protein
MLE07_RS11275	COG4149	molybdate abc transporter
MLE07_RS11280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MLE07_RS11295	COG2022	thiamine diphosphate biosynthetic process
MLE07_RS11310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MLE07_RS11315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLE07_RS11325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MLE07_RS11345	COG1132	(ABC) transporter
MLE07_RS11350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLE07_RS11375	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS11395	COG4166	transmembrane transport
MLE07_RS11400	COG0601	transmembrane transport
MLE07_RS11405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS11415	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS11420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MLE07_RS11425	COG3142	Participates in the control of copper homeostasis
MLE07_RS11430	COG2814	Major facilitator Superfamily
MLE07_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS11450	COG1737	Transcriptional regulator
MLE07_RS11460	COG3842	ATPase activity
MLE07_RS11470	COG0395	ABC-type sugar transport system, permease component
MLE07_RS11490	COG2188	Transcriptional regulator
MLE07_RS11495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MLE07_RS11500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MLE07_RS11505	COG1940	carbohydrate kinase activity
MLE07_RS11515	COG0671	phosphoesterase, PA-phosphatase related
MLE07_RS11520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MLE07_RS11525	COG0156	8-amino-7-oxononanoate synthase activity
MLE07_RS11535	COG0729	surface antigen
MLE07_RS11545	COG0835	chemotaxis
MLE07_RS11555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MLE07_RS11560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MLE07_RS11565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MLE07_RS11570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MLE07_RS11575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MLE07_RS11580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MLE07_RS11595	COG4974	Belongs to the 'phage' integrase family
MLE07_RS11620	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS11630	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLE07_RS11635	COG0567	Dehydrogenase, E1 component
MLE07_RS11640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MLE07_RS11645	COG0045	succinate-CoA ligase (ADP-forming) activity
MLE07_RS11650	COG0039	L-malate dehydrogenase activity
MLE07_RS11655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MLE07_RS11690	COG2264	protein methyltransferase activity
MLE07_RS11705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MLE07_RS11710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MLE07_RS11715	COG0181	hydroxymethylbilane synthase activity
MLE07_RS11755	COG1872	DUF167
MLE07_RS11760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MLE07_RS11770	COG1217	gtp-binding protein TYPA
MLE07_RS11775	COG0339	signal peptide processing
MLE07_RS11780	COG1846	Transcriptional regulator
MLE07_RS11790	COG0137	argininosuccinate synthase activity
MLE07_RS11800	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS11805	COG1122	ATPase activity
MLE07_RS11810	COG4120	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS11820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MLE07_RS11835	COG2154	pterin-4-alpha-carbinolamine dehydratase
MLE07_RS11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLE07_RS11845	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MLE07_RS11855	COG4181	ATPase activity
MLE07_RS11865	COG0670	Belongs to the BI1 family
MLE07_RS11880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MLE07_RS11885	COG4133	protoheme IX ABC transporter activity
MLE07_RS11890	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MLE07_RS11895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MLE07_RS11920	COG2917	probably involved in intracellular septation
MLE07_RS11925	COG0552	protein localization to endoplasmic reticulum
MLE07_RS11930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MLE07_RS11935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MLE07_RS11950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MLE07_RS11955	COG0287	Prephenate dehydrogenase
MLE07_RS11955	COG1605	Chorismate mutase
MLE07_RS11960	COG0228	four-way junction DNA binding
MLE07_RS11965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MLE07_RS11970	COG0336	Belongs to the RNA methyltransferase TrmD family
MLE07_RS11980	COG0335	large ribosomal subunit rRNA binding
MLE07_RS11985	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MLE07_RS11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS12005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MLE07_RS12025	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MLE07_RS12045	COG0488	(ABC) transporter
MLE07_RS12055	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MLE07_RS12065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLE07_RS12070	COG0142	geranyltranstransferase activity
MLE07_RS12075	COG2885	chlorophyll binding
MLE07_RS12080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MLE07_RS12085	COG2223	nitrite transmembrane transporter activity
MLE07_RS12090	COG1349	DNA-binding transcription factor activity
MLE07_RS12095	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MLE07_RS12100	COG2197	response regulator
MLE07_RS12105	COG1132	(ABC) transporter
MLE07_RS12110	COG3459	Glycosyltransferase 36 associated
MLE07_RS12115	COG1473	amidohydrolase
MLE07_RS12125	COG0579	oxidoreductase
MLE07_RS12135	COG0129	dihydroxy-acid dehydratase activity
MLE07_RS12140	COG2084	Dehydrogenase
MLE07_RS12145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS12150	COG0277	FAD linked oxidase domain protein
MLE07_RS12155	COG2186	Transcriptional regulator
MLE07_RS12165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MLE07_RS12170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MLE07_RS12175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MLE07_RS12180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLE07_RS12190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MLE07_RS12195	COG0495	leucyl-tRNA aminoacylation
MLE07_RS12210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MLE07_RS12215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MLE07_RS12230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLE07_RS12235	COG1946	Acyl-CoA thioesterase
MLE07_RS12240	COG0347	Belongs to the P(II) protein family
MLE07_RS12245	COG0004	ammonium transporteR
MLE07_RS12250	COG1674	ftsk spoiiie
MLE07_RS12255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MLE07_RS12270	COG0745	RESPONSE REGULATOR receiver
MLE07_RS12280	COG1329	Transcriptional regulator
MLE07_RS12290	COG2270	Major facilitator Superfamily
MLE07_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS12320	COG0494	nUDIX hydrolase
MLE07_RS12325	COG2861	carbohydrate metabolic process
MLE07_RS12330	COG0793	Belongs to the peptidase S41A family
MLE07_RS12340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MLE07_RS12345	COG0799	negative regulation of ribosome biogenesis
MLE07_RS12350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MLE07_RS12355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MLE07_RS12360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MLE07_RS12365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MLE07_RS12380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MLE07_RS12385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MLE07_RS12410	COG0066	3-isopropylmalate dehydratase activity
MLE07_RS12415	COG0473	3-isopropylmalate dehydrogenase activity
MLE07_RS12420	COG1858	cytochrome C peroxidase
MLE07_RS12425	COG1797	cobyrinic acid a,c-diamide synthase activity
MLE07_RS12435	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MLE07_RS12500	COG1492	cobalamin metabolic process
MLE07_RS12515	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS12520	COG3254	rhamnose metabolic process
MLE07_RS12525	COG0246	Mannitol dehydrogenase
MLE07_RS12530	COG1063	alcohol dehydrogenase
MLE07_RS12555	COG1129	ABC transporter
MLE07_RS12560	COG2186	Transcriptional regulator
MLE07_RS12565	COG2721	sulfolactate sulfo-lyase activity
MLE07_RS12570	COG0138	bifunctional purine biosynthesis protein purh
MLE07_RS12580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MLE07_RS12580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MLE07_RS12585	COG0501	Belongs to the peptidase M48B family
MLE07_RS12605	COG0357	Ribosomal RNA small subunit methyltransferase G
MLE07_RS12610	COG0445	tRNA wobble uridine modification
MLE07_RS12615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MLE07_RS12620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MLE07_RS12625	COG1981	membrane
MLE07_RS12630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MLE07_RS12635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MLE07_RS12640	COG0424	maF-like protein
MLE07_RS12645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MLE07_RS12650	COG0237	dephospho-CoA kinase activity
MLE07_RS12660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MLE07_RS12665	COG3030	protein affecting phage T7 exclusion by the F plasmid
MLE07_RS12675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MLE07_RS12700	COG0179	Fumarylacetoacetate (FAA) hydrolase
MLE07_RS12715	COG0135	phosphoribosylanthranilate isomerase activity
MLE07_RS12720	COG0133	tryptophan synthase activity
MLE07_RS12725	COG0159	tryptophan synthase activity
MLE07_RS12730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MLE07_RS12745	COG1074	ATP-dependent DNA helicase activity
MLE07_RS12755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MLE07_RS12760	COG0802	atpase or kinase
MLE07_RS12765	COG2205	protein histidine kinase activity
MLE07_RS12770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MLE07_RS12775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLE07_RS12780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLE07_RS12780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLE07_RS12785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MLE07_RS12790	COG0642	Histidine kinase
MLE07_RS12795	COG0745	RESPONSE REGULATOR receiver
MLE07_RS12800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MLE07_RS12810	COG1652	LysM domain
MLE07_RS12815	COG1072	(Pantothenic acid kinase))
MLE07_RS12820	COG0140	phosphoribosyl-ATP diphosphatase activity
MLE07_RS12825	COG0107	imidazoleglycerol-phosphate synthase activity
MLE07_RS12830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MLE07_RS12835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MLE07_RS12845	COG0131	Imidazoleglycerol-phosphate dehydratase
MLE07_RS12850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MLE07_RS12855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MLE07_RS12865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MLE07_RS12880	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MLE07_RS12890	COG1643	Atp-dependent helicase
MLE07_RS12950	COG1072	(Pantothenic acid kinase))
MLE07_RS12960	COG1780	Probably involved in ribonucleotide reductase function
MLE07_RS12980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MLE07_RS13010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS13020	COG2813	Specifically methylates the guanine in position
MLE07_RS13025	COG1185	polyribonucleotide nucleotidyltransferase activity
MLE07_RS13030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MLE07_RS13035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MLE07_RS13040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MLE07_RS13045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MLE07_RS13045	COG3064	Membrane
MLE07_RS13060	COG0779	Required for maturation of 30S ribosomal subunits
MLE07_RS13065	COG2814	Major facilitator Superfamily
MLE07_RS13070	COG2951	lytic endotransglycosylase activity
MLE07_RS13075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MLE07_RS13085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MLE07_RS13090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MLE07_RS13105	COG2816	NAD+ diphosphatase activity
MLE07_RS13110	COG0077	Prephenate dehydratase
MLE07_RS13110	COG1605	Chorismate mutase
MLE07_RS13115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MLE07_RS13120	COG3474	cytochrome
MLE07_RS13130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MLE07_RS13140	COG1278	Cold shock
MLE07_RS13145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLE07_RS13155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLE07_RS13155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLE07_RS13165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MLE07_RS13195	COG2900	Belongs to the SlyX family
MLE07_RS13215	COG0484	heat shock protein binding
MLE07_RS13220	COG0443	Heat shock 70 kDa protein
MLE07_RS13240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLE07_RS13245	COG1744	ABC transporter substrate-binding protein PnrA-like
MLE07_RS13250	COG3845	ABC transporter
MLE07_RS13255	COG1079	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS13260	COG1079	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS13265	COG0295	cytidine deaminase activity
MLE07_RS13270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MLE07_RS13275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MLE07_RS13280	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MLE07_RS13290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MLE07_RS13295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MLE07_RS13300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MLE07_RS13310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MLE07_RS13315	COG1845	cytochrome c oxidase, subunit III
MLE07_RS13320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MLE07_RS13325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MLE07_RS13330	COG0477	Major facilitator Superfamily
MLE07_RS13335	COG0067	glutamate synthase
MLE07_RS13335	COG0069	glutamate synthase activity
MLE07_RS13335	COG0070	glutamate synthase
MLE07_RS13340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MLE07_RS13355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MLE07_RS13365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLE07_RS13395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS13415	COG0848	biopolymer transport protein
MLE07_RS13425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MLE07_RS13440	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MLE07_RS13445	COG3454	Phosphonate metabolism
MLE07_RS13450	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MLE07_RS13455	COG3639	organic phosphonate transmembrane transporter activity
MLE07_RS13460	COG3639	organic phosphonate transmembrane transporter activity
MLE07_RS13465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MLE07_RS13470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MLE07_RS13480	COG4778	phosphonate C-P lyase system protein PhnL
MLE07_RS13485	COG4107	phosphonate C-P lyase system protein PhnK
MLE07_RS13490	COG3627	carbon phosphorus lyase activity
MLE07_RS13495	COG3626	phosphonate metabolism
MLE07_RS13500	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
MLE07_RS13505	COG3624	Phosphonate C-P lyase system protein PhnG
MLE07_RS13510	COG2188	Transcriptional regulator
MLE07_RS13515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MLE07_RS13520	COG0837	glucose binding
MLE07_RS13525	COG1803	Methylglyoxal synthase
MLE07_RS13530	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
MLE07_RS13535	COG4166	transmembrane transport
MLE07_RS13540	COG4174	ABC transporter (Permease)
MLE07_RS13545	COG4239	(ABC) transporter, permease
MLE07_RS13550	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS13555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS13560	COG0174	glutamine synthetase
MLE07_RS13565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS13570	COG3265	gluconokinase activity
MLE07_RS13575	COG1174	glycine betaine transport
MLE07_RS13580	COG1125	glycine betaine transport
MLE07_RS13585	COG1174	glycine betaine transport
MLE07_RS13590	COG1732	Glycine betaine
MLE07_RS13600	COG1959	2 iron, 2 sulfur cluster binding
MLE07_RS13605	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS13615	COG4269	membrane
MLE07_RS13630	COG0697	spore germination
MLE07_RS13645	COG0791	NLP P60 protein
MLE07_RS13655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MLE07_RS13660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MLE07_RS13695	COG4964	Belongs to the GSP D family
MLE07_RS13730	COG2963	transposase activity
MLE07_RS13735	COG3436	PFAM IS66 Orf2 family protein
MLE07_RS13740	COG4372	Transposase
MLE07_RS13750	COG2815	serine threonine protein kinase
MLE07_RS13750	COG0515	serine threonine protein kinase
MLE07_RS13810	COG3422	double-strand break repair
MLE07_RS13815	COG3757	hydrolase, family 25
MLE07_RS13820	COG0697	spore germination
MLE07_RS13825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLE07_RS13840	COG0492	ferredoxin-NADP+ reductase activity
MLE07_RS13855	COG0481	GTPase activity
MLE07_RS13860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLE07_RS13875	COG1396	sequence-specific DNA binding
MLE07_RS13890	COG2169	Transcriptional regulator
MLE07_RS13890	COG1917	Cupin 2, conserved barrel domain protein
MLE07_RS13895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MLE07_RS13920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MLE07_RS13925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MLE07_RS13930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MLE07_RS13940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MLE07_RS13945	COG0072	phenylalanine-tRNA ligase activity
MLE07_RS13945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLE07_RS13950	COG0667	Aldo Keto reductase
MLE07_RS13970	COG4977	sequence-specific DNA binding
MLE07_RS13995	COG1570	exodeoxyribonuclease VII activity
MLE07_RS14000	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS14010	COG1846	Transcriptional regulator
MLE07_RS14015	COG0697	spore germination
MLE07_RS14020	COG2309	aminopeptidase activity
MLE07_RS14030	COG1393	Belongs to the ArsC family
MLE07_RS14050	COG1309	transcriptional regulator
MLE07_RS14060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MLE07_RS14060	COG0519	Catalyzes the synthesis of GMP from XMP
MLE07_RS14075	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MLE07_RS14105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MLE07_RS14115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MLE07_RS14125	COG1968	undecaprenyl-diphosphatase activity
MLE07_RS14140	COG0284	orotidine-5'-phosphate decarboxylase activity
MLE07_RS14150	COG3963	phosphatidate phosphatase activity
MLE07_RS14160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MLE07_RS14165	COG0792	nuclease activity
MLE07_RS14180	COG1175	transmembrane transport
MLE07_RS14185	COG0395	ABC-type sugar transport system, permease component
MLE07_RS14190	COG3842	ATPase activity
MLE07_RS14200	COG0189	ligase activity
MLE07_RS14205	COG0606	chelatase, subunit chli
MLE07_RS14210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLE07_RS14215	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS14220	COG0756	dUTP diphosphatase activity
MLE07_RS14225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MLE07_RS14230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MLE07_RS14245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MLE07_RS14250	COG2226	methyltransferase
MLE07_RS14255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MLE07_RS14260	COG1024	Enoyl-CoA hydratase
MLE07_RS14265	COG0268	Binds directly to 16S ribosomal RNA
MLE07_RS14295	COG1278	Cold shock
MLE07_RS14380	COG1278	Cold shock
MLE07_RS14390	COG0604	alcohol dehydrogenase
MLE07_RS14395	COG1733	regulation of RNA biosynthetic process
MLE07_RS14415	COG1522	sequence-specific DNA binding
MLE07_RS14440	COG0596	Alpha beta hydrolase
MLE07_RS14455	COG1764	response to oxidative stress
MLE07_RS14465	COG0596	Alpha beta hydrolase
MLE07_RS14485	COG0783	Belongs to the Dps family
MLE07_RS14490	COG0243	molybdopterin cofactor binding
MLE07_RS14500	COG4566	intracellular signal transduction
MLE07_RS14505	COG4566	intracellular signal transduction
MLE07_RS14515	COG2140	Oxalate decarboxylase
MLE07_RS14530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MLE07_RS14530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MLE07_RS14535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MLE07_RS14545	COG1414	Transcriptional regulator
MLE07_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS14580	COG1522	sequence-specific DNA binding
MLE07_RS14600	COG0628	permease
MLE07_RS14610	COG2235	arginine
MLE07_RS14645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLE07_RS14655	COG0702	epimerase
MLE07_RS14660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLE07_RS14665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS14670	COG0745	RESPONSE REGULATOR receiver
MLE07_RS14675	COG5002	protein histidine kinase activity
MLE07_RS14690	COG2233	PERMEase
MLE07_RS14750	COG0395	ABC-type sugar transport system, permease component
MLE07_RS14755	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS14765	COG3842	ATPase activity
MLE07_RS14810	COG0395	ABC-type sugar transport system, permease component
MLE07_RS14815	COG3842	ATPase activity
MLE07_RS14830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLE07_RS14835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS14840	COG1116	anion transmembrane transporter activity
MLE07_RS14845	COG0395	ABC-type sugar transport system, permease component
MLE07_RS14850	COG1175	transmembrane transport
MLE07_RS14880	COG1609	Transcriptional regulator
MLE07_RS14895	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS14910	COG3842	ATPase activity
MLE07_RS14915	COG0395	ABC-type sugar transport system, permease component
MLE07_RS14920	COG1175	transmembrane transport
MLE07_RS14925	COG1653	transport
MLE07_RS14930	COG1309	transcriptional regulator
MLE07_RS14935	COG0673	inositol 2-dehydrogenase activity
MLE07_RS14950	COG0673	inositol 2-dehydrogenase activity
MLE07_RS14960	COG1278	Cold shock
MLE07_RS14970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MLE07_RS14995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLE07_RS15000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MLE07_RS15015	COG3842	ATPase activity
MLE07_RS15020	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15025	COG1175	transmembrane transport
MLE07_RS15035	COG3618	amidohydrolase
MLE07_RS15040	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS15045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS15055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MLE07_RS15060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS15065	COG2186	Transcriptional regulator
MLE07_RS15080	COG0667	Aldo Keto reductase
MLE07_RS15110	COG4977	sequence-specific DNA binding
MLE07_RS15115	COG2223	nitrite transmembrane transporter activity
MLE07_RS15120	COG1609	Transcriptional regulator
MLE07_RS15125	COG1063	alcohol dehydrogenase
MLE07_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS15140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS15145	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
MLE07_RS15150	COG1175	transmembrane transport
MLE07_RS15155	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15170	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15175	COG1175	transmembrane transport
MLE07_RS15180	COG2182	Extracellular solute-binding protein
MLE07_RS15185	COG0626	cystathionine gamma-synthase activity
MLE07_RS15200	COG0454	-acetyltransferase
MLE07_RS15205	COG0803	Belongs to the bacterial solute-binding protein 9 family
MLE07_RS15215	COG1121	(ABC) transporter
MLE07_RS15220	COG0523	cobalamin synthesis protein
MLE07_RS15235	COG0523	cobalamin synthesis protein
MLE07_RS15240	COG1653	transport
MLE07_RS15245	COG1175	transmembrane transport
MLE07_RS15250	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15255	COG3842	ATPase activity
MLE07_RS15265	COG3047	cAMP biosynthetic process
MLE07_RS15290	COG0583	DNA-binding transcription factor activity
MLE07_RS15295	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS15305	COG1129	ABC transporter
MLE07_RS15315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLE07_RS15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS15340	COG3257	ureidoglycine aminohydrolase activity
MLE07_RS15350	COG5001	Diguanylate cyclase
MLE07_RS15355	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MLE07_RS15365	COG0747	negative chemotaxis
MLE07_RS15370	COG0601	transmembrane transport
MLE07_RS15375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS15380	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS15385	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS15390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MLE07_RS15405	COG0346	lactoylglutathione lyase activity
MLE07_RS15415	COG0129	dihydroxy-acid dehydratase activity
MLE07_RS15420	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS15425	COG1129	ABC transporter
MLE07_RS15430	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS15435	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS15440	COG2186	Transcriptional regulator
MLE07_RS15455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLE07_RS15460	COG0587	DNA-directed DNA polymerase activity
MLE07_RS15490	COG0673	inositol 2-dehydrogenase activity
MLE07_RS15500	COG3842	ATPase activity
MLE07_RS15505	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15510	COG1175	transmembrane transport
MLE07_RS15515	COG1653	transport
MLE07_RS15525	COG0673	inositol 2-dehydrogenase activity
MLE07_RS15540	COG5001	Diguanylate cyclase
MLE07_RS15555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MLE07_RS15560	COG2894	cell division
MLE07_RS15565	COG0850	regulation of cytokinetic process
MLE07_RS15570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MLE07_RS15575	COG2186	Transcriptional regulator
MLE07_RS15580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MLE07_RS15590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MLE07_RS15595	COG1063	alcohol dehydrogenase
MLE07_RS15600	COG1312	Catalyzes the dehydration of D-mannonate
MLE07_RS15620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MLE07_RS15625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MLE07_RS15625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MLE07_RS15630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS15645	COG0625	glutathione transferase activity
MLE07_RS15655	COG1921	L-seryl-tRNASec selenium transferase activity
MLE07_RS15670	COG3964	amidohydrolase
MLE07_RS15680	COG0601	transmembrane transport
MLE07_RS15685	COG0747	negative chemotaxis
MLE07_RS15690	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS15725	COG4989	oxidoreductase activity
MLE07_RS15735	COG2188	Transcriptional regulator
MLE07_RS15745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MLE07_RS15760	COG3842	ATPase activity
MLE07_RS15765	COG1653	transport
MLE07_RS15770	COG1175	transmembrane transport
MLE07_RS15775	COG0395	ABC-type sugar transport system, permease component
MLE07_RS15780	COG1501	Belongs to the glycosyl hydrolase 31 family
MLE07_RS15790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS15795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLE07_RS15800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MLE07_RS15805	COG0352	thiamine-phosphate diphosphorylase activity
MLE07_RS15810	COG0351	phosphomethylpyrimidine kinase
MLE07_RS15815	COG1522	sequence-specific DNA binding
MLE07_RS15820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MLE07_RS15825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS15840	COG2204	response regulator
MLE07_RS15845	COG4191	Histidine kinase
MLE07_RS15850	COG1301	dicarboxylic acid transport
MLE07_RS15855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLE07_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS15870	COG1473	amidohydrolase
MLE07_RS15890	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS15900	COG2942	2-epimerase
MLE07_RS15925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS15935	COG2197	response regulator
MLE07_RS15965	COG3307	-O-antigen
MLE07_RS15970	COG1596	polysaccharide export
MLE07_RS15975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MLE07_RS15985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLE07_RS15990	COG0840	transmembrane signaling receptor activity
MLE07_RS15990	COG2972	Histidine kinase
MLE07_RS15995	COG1376	ErfK ybiS ycfS ynhG family protein
MLE07_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS16015	COG2094	Belongs to the DNA glycosylase MPG family
MLE07_RS16030	COG1609	Transcriptional regulator
MLE07_RS16035	COG1653	transport
MLE07_RS16050	COG3842	ATPase activity
MLE07_RS16060	COG0673	inositol 2-dehydrogenase activity
MLE07_RS16065	COG0602	queuosine metabolic process
MLE07_RS16070	COG0720	synthase
MLE07_RS16075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MLE07_RS16080	COG0673	inositol 2-dehydrogenase activity
MLE07_RS16095	COG0395	ABC-type sugar transport system, permease component
MLE07_RS16100	COG1175	transmembrane transport
MLE07_RS16125	COG0583	DNA-binding transcription factor activity
MLE07_RS16130	COG0281	malic enzyme
MLE07_RS16130	COG0280	phosphate acetyltransferase
MLE07_RS16145	COG0765	amino acid transport
MLE07_RS16150	COG1126	abc transporter atp-binding protein
MLE07_RS16155	COG2079	MmgE PrpD family protein
MLE07_RS16160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS16185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MLE07_RS16195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MLE07_RS16200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MLE07_RS16205	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS16210	COG1129	ABC transporter
MLE07_RS16225	COG1473	amidohydrolase
MLE07_RS16230	COG0747	negative chemotaxis
MLE07_RS16245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS16250	COG0601	transmembrane transport
MLE07_RS16255	COG0583	DNA-binding transcription factor activity
MLE07_RS16260	COG1446	asparaginase
MLE07_RS16275	COG0747	negative chemotaxis
MLE07_RS16295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS16300	COG0601	transmembrane transport
MLE07_RS16305	COG2197	response regulator
MLE07_RS16310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MLE07_RS16315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS16325	COG3842	ATPase activity
MLE07_RS16330	COG0395	ABC-type sugar transport system, permease component
MLE07_RS16335	COG1175	transmembrane transport
MLE07_RS16345	COG0673	inositol 2-dehydrogenase activity
MLE07_RS16350	COG0673	inositol 2-dehydrogenase activity
MLE07_RS16370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS16375	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MLE07_RS16395	COG1595	DNA-templated transcription, initiation
MLE07_RS16400	COG1120	ATPase activity
MLE07_RS16405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS16420	COG2226	methyltransferase
MLE07_RS16430	COG1120	ATPase activity
MLE07_RS16435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS16480	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS16485	COG0473	3-isopropylmalate dehydrogenase activity
MLE07_RS16490	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS16495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS16530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS16535	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS16540	COG1522	sequence-specific DNA binding
MLE07_RS16550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS16565	COG0583	DNA-binding transcription factor activity
MLE07_RS16575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS16580	COG1126	abc transporter atp-binding protein
MLE07_RS16595	COG1473	amidohydrolase
MLE07_RS16600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16610	COG1959	2 iron, 2 sulfur cluster binding
MLE07_RS16620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MLE07_RS16625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16655	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS16665	COG0747	negative chemotaxis
MLE07_RS16680	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS16690	COG0667	Aldo Keto reductase
MLE07_RS16700	COG0583	DNA-binding transcription factor activity
MLE07_RS16705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16710	COG4166	transmembrane transport
MLE07_RS16720	COG0747	negative chemotaxis
MLE07_RS16725	COG1473	amidohydrolase
MLE07_RS16730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS16770	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS16775	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS16785	COG0601	transmembrane transport
MLE07_RS16795	COG2186	Transcriptional regulator
MLE07_RS16810	COG0300	oxidoreductase activity
MLE07_RS16820	COG3453	Protein conserved in bacteria
MLE07_RS16820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLE07_RS16825	COG0640	Transcriptional regulator
MLE07_RS16835	COG2391	methyltransferase activity
MLE07_RS16840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MLE07_RS16850	COG0022	dehydrogenase e1 component
MLE07_RS16860	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS16865	COG0183	Belongs to the thiolase family
MLE07_RS16875	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS16880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MLE07_RS16900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MLE07_RS16905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MLE07_RS16910	COG4952	isomerase
MLE07_RS16915	COG3347	Dehydrogenase
MLE07_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS16920	COG1349	DNA-binding transcription factor activity
MLE07_RS16930	COG1129	ABC transporter
MLE07_RS16935	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS16940	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS16945	COG3254	rhamnose metabolic process
MLE07_RS16960	COG2264	protein methyltransferase activity
MLE07_RS16965	COG5001	Diguanylate cyclase
MLE07_RS16980	COG4335	DNA alkylation repair
MLE07_RS16985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MLE07_RS16990	COG4208	sulfate ABC transporter
MLE07_RS17000	COG4150	thiosulfate binding
MLE07_RS17005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MLE07_RS17020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLE07_RS17030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLE07_RS17040	COG1040	competence protein
MLE07_RS17045	COG2226	methyltransferase
MLE07_RS17060	COG0494	nUDIX hydrolase
MLE07_RS17070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MLE07_RS17075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLE07_RS17080	COG0653	protein targeting
MLE07_RS17085	COG0697	spore germination
MLE07_RS17135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLE07_RS17155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MLE07_RS17200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS17200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MLE07_RS17220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MLE07_RS17225	COG2086	electron transfer activity
MLE07_RS17230	COG0477	Major facilitator Superfamily
MLE07_RS17235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MLE07_RS17255	COG2963	transposase activity
MLE07_RS17260	COG3436	PFAM IS66 Orf2 family protein
MLE07_RS17265	COG4372	Transposase
MLE07_RS17280	COG0840	transmembrane signaling receptor activity
MLE07_RS17305	COG1840	ABC-type Fe3 transport system, periplasmic component
MLE07_RS17310	COG1177	transmembrane transport
MLE07_RS17315	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS17320	COG3842	ATPase activity
MLE07_RS17325	COG1335	isochorismatase
MLE07_RS17330	COG2309	aminopeptidase activity
MLE07_RS17335	COG0596	Alpha beta hydrolase
MLE07_RS17340	COG3473	Maleate cis-trans isomerase
MLE07_RS17350	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS17390	COG2259	Doxx family
MLE07_RS17405	COG0583	DNA-binding transcription factor activity
MLE07_RS17410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MLE07_RS17425	COG0583	DNA-binding transcription factor activity
MLE07_RS17430	COG2514	catechol 2,3-dioxygenase activity
MLE07_RS17450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MLE07_RS17460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS17460	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS17465	COG4311	Sarcosine oxidase, delta subunit
MLE07_RS17470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS17475	COG4977	sequence-specific DNA binding
MLE07_RS17485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MLE07_RS17490	COG2218	PFAM glutamate synthase alpha subunit domain protein
MLE07_RS17495	COG0069	glutamate synthase activity
MLE07_RS17500	COG0174	glutamine synthetase
MLE07_RS17520	COG0531	amino acid
MLE07_RS17550	COG2353	YceI-like domain
MLE07_RS17565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MLE07_RS17580	COG3842	ATPase activity
MLE07_RS17585	COG0395	ABC-type sugar transport system, permease component
MLE07_RS17590	COG1175	transmembrane transport
MLE07_RS17600	COG1472	Belongs to the glycosyl hydrolase 3 family
MLE07_RS17705	COG2856	Zn peptidase
MLE07_RS17765	COG2244	polysaccharide biosynthetic process
MLE07_RS17780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MLE07_RS17790	COG0489	protein tyrosine kinase activity
MLE07_RS17790	COG3206	protein involved in exopolysaccharide biosynthesis
MLE07_RS17810	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS17815	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS17830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MLE07_RS17835	COG2273	Hydrolase Family 16
MLE07_RS17835	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MLE07_RS17850	COG3842	ATPase activity
MLE07_RS17855	COG3833	ABC-type maltose transport systems, permease component
MLE07_RS17910	COG1396	sequence-specific DNA binding
MLE07_RS17920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MLE07_RS17925	COG1129	ABC transporter
MLE07_RS17930	COG4214	carbohydrate transport
MLE07_RS17935	COG4213	ABC transporter substrate-binding protein
MLE07_RS17950	COG0346	lactoylglutathione lyase activity
MLE07_RS17955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MLE07_RS17955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MLE07_RS17960	COG4770	biotin carboxylase activity
MLE07_RS17975	COG0625	glutathione transferase activity
MLE07_RS17980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MLE07_RS17985	COG1396	sequence-specific DNA binding
MLE07_RS17985	COG3800	Transcriptional regulator
MLE07_RS17995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MLE07_RS18005	COG0300	oxidoreductase activity
MLE07_RS18015	COG2096	Adenosyltransferase
MLE07_RS18025	COG2086	electron transfer activity
MLE07_RS18035	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLE07_RS18045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLE07_RS18050	COG0165	Argininosuccinate lyase
MLE07_RS18085	COG2884	Cell division ATP-binding protein ftsE
MLE07_RS18105	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MLE07_RS18115	COG0287	Prephenate dehydrogenase
MLE07_RS18120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MLE07_RS18125	COG2226	methyltransferase
MLE07_RS18130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLE07_RS18150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MLE07_RS18155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MLE07_RS18195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MLE07_RS18200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MLE07_RS18210	COG4974	Belongs to the 'phage' integrase family
MLE07_RS18215	COG0825	malonyl-CoA metabolic process
MLE07_RS18220	COG3034	peptidoglycan biosynthetic process
MLE07_RS18225	COG0425	Belongs to the sulfur carrier protein TusA family
MLE07_RS18225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLE07_RS18230	COG0523	cobalamin synthesis protein
MLE07_RS18235	COG1686	Belongs to the peptidase S11 family
MLE07_RS18240	COG1473	amidohydrolase
MLE07_RS18250	COG4953	penicillin-binding protein 1C
MLE07_RS18255	COG2373	Large extracellular alpha-helical protein
MLE07_RS18260	COG2835	tetraacyldisaccharide 4'-kinase activity
MLE07_RS18290	COG0482	sulfurtransferase activity
MLE07_RS18305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MLE07_RS18320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MLE07_RS18325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MLE07_RS18330	COG0037	tRNA processing
MLE07_RS18340	COG2885	chlorophyll binding
MLE07_RS18345	COG0823	Involved in the tonB-independent uptake of proteins
MLE07_RS18365	COG0824	Thioesterase
MLE07_RS18375	COG0494	nUDIX hydrolase
MLE07_RS18390	COG2255	four-way junction helicase activity
MLE07_RS18395	COG0632	four-way junction helicase activity
MLE07_RS18400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MLE07_RS18405	COG0840	transmembrane signaling receptor activity
MLE07_RS18410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS18415	COG0217	transcriptional regulatory protein
MLE07_RS18430	COG1692	metallophosphoesterase
MLE07_RS18440	COG1253	flavin adenine dinucleotide binding
MLE07_RS18475	COG3263	regulation of cellular component size
MLE07_RS18480	COG0126	phosphoglycerate kinase activity
MLE07_RS18485	COG3588	fructose-bisphosphate aldolase
MLE07_RS18510	COG0254	rRNA binding
MLE07_RS18515	COG1132	(ABC) transporter
MLE07_RS18540	COG0483	inositol monophosphate 1-phosphatase activity
MLE07_RS18570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MLE07_RS18575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MLE07_RS18580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MLE07_RS18585	COG0457	Tetratricopeptide repeat
MLE07_RS18595	COG3750	Belongs to the UPF0335 family
MLE07_RS18615	COG0469	pyruvate kinase activity
MLE07_RS18620	COG3108	Peptidase M15
MLE07_RS18625	COG2204	response regulator
MLE07_RS18630	COG1164	Oligoendopeptidase f
MLE07_RS18635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLE07_RS18645	COG5310	Homospermidine synthase
MLE07_RS18655	COG0737	Belongs to the 5'-nucleotidase family
MLE07_RS18660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MLE07_RS18665	COG0330	HflC and HflK could
MLE07_RS18695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MLE07_RS18700	COG2951	lytic endotransglycosylase activity
MLE07_RS18710	COG0745	RESPONSE REGULATOR receiver
MLE07_RS18715	COG2205	protein histidine kinase activity
MLE07_RS18730	COG0067	glutamate synthase
MLE07_RS18730	COG0070	glutamate synthase
MLE07_RS18730	COG0069	glutamate synthase activity
MLE07_RS18745	COG2205	protein histidine kinase activity
MLE07_RS18750	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MLE07_RS18755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MLE07_RS18765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MLE07_RS18775	COG0252	asparaginase activity
MLE07_RS18785	COG1027	Aspartate ammonia-lyase
MLE07_RS18790	COG2186	Transcriptional regulator
MLE07_RS18810	COG1309	transcriptional regulator
MLE07_RS18830	COG4176	ABC-type proline glycine betaine transport system permease component
MLE07_RS18835	COG0517	IMP dehydrogenase activity
MLE07_RS18835	COG4175	Glycine betaine
MLE07_RS18840	COG2986	histidine ammonia-lyase
MLE07_RS18845	COG1609	Transcriptional regulator
MLE07_RS18865	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS18870	COG0673	inositol 2-dehydrogenase activity
MLE07_RS18875	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS18880	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS18920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MLE07_RS18940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS18945	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS18950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS18955	COG0601	transmembrane transport
MLE07_RS18960	COG0747	negative chemotaxis
MLE07_RS18970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MLE07_RS18975	COG1454	alcohol dehydrogenase
MLE07_RS19015	COG2307	Protein conserved in bacteria
MLE07_RS19015	COG2308	Evidence 4 Homologs of previously reported genes of
MLE07_RS19030	COG0488	(ABC) transporter
MLE07_RS19035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLE07_RS19040	COG2186	Transcriptional regulator
MLE07_RS19055	COG1175	transmembrane transport
MLE07_RS19060	COG0395	ABC-type sugar transport system, permease component
MLE07_RS19070	COG3842	ATPase activity
MLE07_RS19095	COG1304	FMN binding
MLE07_RS19110	COG1063	alcohol dehydrogenase
MLE07_RS19115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MLE07_RS19120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS19130	COG0765	amino acid transport
MLE07_RS19135	COG0765	amino acid transport
MLE07_RS19140	COG4221	oxidoreductase activity
MLE07_RS19145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLE07_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS19155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS19170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MLE07_RS19185	COG0697	spore germination
MLE07_RS19190	COG0697	spore germination
MLE07_RS19195	COG0511	ligase activity, forming carbon-carbon bonds
MLE07_RS19200	COG0439	Biotin carboxylase
MLE07_RS19210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MLE07_RS19215	COG1984	allophanate hydrolase subunit 2
MLE07_RS19220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MLE07_RS19225	COG3842	ATPase activity
MLE07_RS19235	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MLE07_RS19245	COG0436	Aminotransferase
MLE07_RS19260	COG0840	transmembrane signaling receptor activity
MLE07_RS19265	COG1070	Carbohydrate kinase
MLE07_RS19270	COG1830	Aldolase
MLE07_RS19275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MLE07_RS19280	COG0667	Aldo Keto reductase
MLE07_RS19290	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS19295	COG1129	ABC transporter
MLE07_RS19300	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS19335	COG0071	Belongs to the small heat shock protein (HSP20) family
MLE07_RS19350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MLE07_RS19365	COG0395	ABC-type sugar transport system, permease component
MLE07_RS19380	COG3842	ATPase activity
MLE07_RS19395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MLE07_RS19395	COG1648	precorrin-2 dehydrogenase activity
MLE07_RS19400	COG0243	molybdopterin cofactor binding
MLE07_RS19410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MLE07_RS19415	COG1116	anion transmembrane transporter activity
MLE07_RS19420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS19425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLE07_RS19435	COG3707	response regulator
MLE07_RS19440	COG1802	Transcriptional regulator
MLE07_RS19445	COG1914	H( )-stimulated, divalent metal cation uptake system
MLE07_RS19450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MLE07_RS19455	COG4336	lyase activity
MLE07_RS19460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MLE07_RS19465	COG4770	biotin carboxylase activity
MLE07_RS19470	COG0366	Alpha amylase catalytic
MLE07_RS19480	COG4771	TonB-dependent receptor
MLE07_RS19485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MLE07_RS19505	COG1414	Transcriptional regulator
MLE07_RS19510	COG1475	DNA binding
MLE07_RS19515	COG1192	Involved in chromosome partitioning
MLE07_RS19545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MLE07_RS19555	COG2986	histidine ammonia-lyase
MLE07_RS19560	COG1228	amidohydrolase
MLE07_RS19565	COG0402	S-adenosylhomocysteine deaminase activity
MLE07_RS19640	COG0596	Alpha beta hydrolase
MLE07_RS19665	COG0405	Gamma-glutamyltransferase
MLE07_RS19675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLE07_RS19680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS19685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS19695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS19700	COG0747	negative chemotaxis
MLE07_RS19705	COG0747	negative chemotaxis
MLE07_RS19715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS19725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS19735	COG1129	ABC transporter
MLE07_RS19740	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS19745	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS19770	COG0667	Aldo Keto reductase
MLE07_RS19785	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS19790	COG1129	ABC transporter
MLE07_RS19795	COG4213	ABC transporter substrate-binding protein
MLE07_RS19815	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS19820	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS19825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS19830	COG0601	transmembrane transport
MLE07_RS19835	COG0747	negative chemotaxis
MLE07_RS19860	COG0765	amino acid transport
MLE07_RS19865	COG4597	amino acid ABC transporter
MLE07_RS19870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS19960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS19965	COG1136	(ABC) transporter
MLE07_RS19965	COG0577	efflux transmembrane transporter activity
MLE07_RS19980	COG1846	Transcriptional regulator
MLE07_RS20000	COG0667	Aldo Keto reductase
MLE07_RS20005	COG0604	alcohol dehydrogenase
MLE07_RS20015	COG1309	transcriptional regulator
MLE07_RS20030	COG0667	Aldo Keto reductase
MLE07_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS20050	COG0662	Cupin 2, conserved barrel domain protein
MLE07_RS20050	COG2207	Transcriptional regulator
MLE07_RS20055	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS20060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS20065	COG0601	transmembrane transport
MLE07_RS20070	COG4166	transmembrane transport
MLE07_RS20075	COG0395	ABC-type sugar transport system, permease component
MLE07_RS20095	COG1566	PFAM secretion protein HlyD family protein
MLE07_RS20110	COG2207	Transcriptional regulator
MLE07_RS20115	COG1309	transcriptional regulator
MLE07_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS20145	COG1846	Transcriptional regulator
MLE07_RS20150	COG0583	DNA-binding transcription factor activity
MLE07_RS20155	COG2828	Protein conserved in bacteria
MLE07_RS20170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS20185	COG0840	transmembrane signaling receptor activity
MLE07_RS20205	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS20220	COG0583	DNA-binding transcription factor activity
MLE07_RS20225	COG0346	lactoylglutathione lyase activity
MLE07_RS20240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MLE07_RS20260	COG0583	DNA-binding transcription factor activity
MLE07_RS20265	COG0477	Major facilitator Superfamily
MLE07_RS20275	COG2205	protein histidine kinase activity
MLE07_RS20280	COG0745	RESPONSE REGULATOR receiver
MLE07_RS20285	COG0671	phosphoesterase, PA-phosphatase related
MLE07_RS20335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MLE07_RS20345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MLE07_RS20350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLE07_RS20355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLE07_RS20370	COG0010	Belongs to the arginase family
MLE07_RS20380	COG0697	spore germination
MLE07_RS20385	COG0673	inositol 2-dehydrogenase activity
MLE07_RS20405	COG0477	Major facilitator Superfamily
MLE07_RS20420	COG2194	sulfuric ester hydrolase activity
MLE07_RS20430	COG0583	DNA-binding transcription factor activity
MLE07_RS20435	COG4774	siderophore transport
MLE07_RS20450	COG1120	ATPase activity
MLE07_RS20460	COG3474	cytochrome
MLE07_RS20465	COG2137	regulation of response to DNA damage stimulus
MLE07_RS20470	COG3386	PFAM SMP-30 Gluconolaconase
MLE07_RS20480	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS20485	COG1129	ABC transporter
MLE07_RS20490	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS20495	COG4585	Histidine kinase
MLE07_RS20500	COG2197	response regulator
MLE07_RS20510	COG2133	pyrroloquinoline quinone binding
MLE07_RS20520	COG0500	methyltransferase
MLE07_RS20525	COG0564	pseudouridine synthase activity
MLE07_RS20540	COG3448	diguanylate cyclase activity
MLE07_RS20540	COG4175	Glycine betaine
MLE07_RS20545	COG4176	ABC-type proline glycine betaine transport system permease component
MLE07_RS20560	COG0784	Response regulator, receiver
MLE07_RS20560	COG4191	Histidine kinase
MLE07_RS20565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MLE07_RS20570	COG3206	protein involved in exopolysaccharide biosynthesis
MLE07_RS20570	COG0489	protein tyrosine kinase activity
MLE07_RS20575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MLE07_RS20580	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS20585	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS20590	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS20595	COG0438	transferase activity, transferring glycosyl groups
MLE07_RS20600	COG2273	Hydrolase Family 16
MLE07_RS20605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MLE07_RS20610	COG2244	polysaccharide biosynthetic process
MLE07_RS20615	COG0463	Glycosyl transferase, family 2
MLE07_RS20620	COG2327	Polysaccharide pyruvyl transferase
MLE07_RS20625	COG1215	transferase activity, transferring glycosyl groups
MLE07_RS20645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MLE07_RS20650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS20665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS20665	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS20695	COG1523	belongs to the glycosyl hydrolase 13 family
MLE07_RS20700	COG0033	Phosphoglucomutase
MLE07_RS20705	COG0297	glycogen (starch) synthase activity
MLE07_RS20710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MLE07_RS20715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MLE07_RS20720	COG0058	SHG alpha-glucan phosphorylase activity
MLE07_RS20735	COG1794	racemase activity, acting on amino acids and derivatives
MLE07_RS20740	COG1522	sequence-specific DNA binding
MLE07_RS20750	COG2084	Dehydrogenase
MLE07_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS20760	COG1063	alcohol dehydrogenase
MLE07_RS20770	COG4988	ABC transporter
MLE07_RS20775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MLE07_RS20785	COG1294	oxidase, subunit
MLE07_RS20815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MLE07_RS20820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MLE07_RS20850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MLE07_RS20855	COG0539	negative regulation of cytoplasmic translation
MLE07_RS20885	COG4221	oxidoreductase activity
MLE07_RS20895	COG0747	negative chemotaxis
MLE07_RS20900	COG0601	transmembrane transport
MLE07_RS20905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS20910	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS20915	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS20920	COG0246	Mannitol dehydrogenase
MLE07_RS20935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS20980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLE07_RS20985	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS21000	COG4993	Dehydrogenase
MLE07_RS21005	COG3685	Protein conserved in bacteria
MLE07_RS21035	COG0693	protein deglycase activity
MLE07_RS21055	COG0189	ligase activity
MLE07_RS21060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLE07_RS21065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MLE07_RS21080	COG0435	Glutathione S-transferase
MLE07_RS21085	COG0583	DNA-binding transcription factor activity
MLE07_RS21090	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS21095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLE07_RS21100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLE07_RS21105	COG1116	anion transmembrane transporter activity
MLE07_RS21115	COG1522	sequence-specific DNA binding
MLE07_RS21130	COG0784	Response regulator, receiver
MLE07_RS21140	COG3920	Histidine kinase
MLE07_RS21150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MLE07_RS21165	COG0019	diaminopimelate decarboxylase activity
MLE07_RS21180	COG0527	aspartate kinase activity
MLE07_RS21190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MLE07_RS21195	COG2890	protein-(glutamine-N5) methyltransferase activity
MLE07_RS21205	COG0542	response to heat
MLE07_RS21210	COG1196	nuclear chromosome segregation
MLE07_RS21210	COG0741	lytic transglycosylase activity
MLE07_RS21210	COG0739	heme binding
MLE07_RS21255	COG2831	hemolysin activation secretion protein
MLE07_RS21260	COG3210	domain, Protein
MLE07_RS21285	COG2376	Dihydroxyacetone kinase
MLE07_RS21290	COG1522	sequence-specific DNA binding
MLE07_RS21310	COG0431	NADPH-dependent FMN reductase
MLE07_RS21320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS21330	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS21335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS21355	COG0277	FAD linked oxidase domain protein
MLE07_RS21375	COG0778	Nitroreductase
MLE07_RS21405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLE07_RS21430	COG2318	DinB family
MLE07_RS21435	COG0583	DNA-binding transcription factor activity
MLE07_RS21450	COG1335	isochorismatase
MLE07_RS21475	COG3842	ATPase activity
MLE07_RS21480	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS21485	COG1177	transmembrane transport
MLE07_RS21490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MLE07_RS21500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MLE07_RS21515	COG1120	ATPase activity
MLE07_RS21520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS21525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS21530	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MLE07_RS21535	COG1629	transport
MLE07_RS21535	COG4774	siderophore transport
MLE07_RS21540	COG4702	Belongs to the UPF0303 family
MLE07_RS21560	COG1024	Enoyl-CoA hydratase
MLE07_RS21565	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS21570	COG1653	transport
MLE07_RS21575	COG1175	transmembrane transport
MLE07_RS21580	COG0395	ABC-type sugar transport system, permease component
MLE07_RS21585	COG3842	ATPase activity
MLE07_RS21610	COG3474	cytochrome
MLE07_RS21615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MLE07_RS21620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MLE07_RS21625	COG1845	cytochrome c oxidase, subunit III
MLE07_RS21640	COG0047	phosphoribosylformylglycinamidine synthase activity
MLE07_RS21655	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS21655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS21665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MLE07_RS21685	COG1309	transcriptional regulator
MLE07_RS21700	COG1136	(ABC) transporter
MLE07_RS21715	COG1063	alcohol dehydrogenase
MLE07_RS21725	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS21735	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS21755	COG0477	Major facilitator Superfamily
MLE07_RS21895	COG5001	Diguanylate cyclase
MLE07_RS21895	COG3300	MHYT domain
MLE07_RS21920	COG1253	flavin adenine dinucleotide binding
MLE07_RS21935	COG3842	ATPase activity
MLE07_RS21940	COG0395	ABC-type sugar transport system, permease component
MLE07_RS21945	COG1175	transmembrane transport
MLE07_RS21950	COG1653	transport
MLE07_RS21960	COG0673	inositol 2-dehydrogenase activity
MLE07_RS21965	COG1609	Transcriptional regulator
MLE07_RS21980	COG0583	DNA-binding transcription factor activity
MLE07_RS21990	COG1879	ABC-type sugar transport system periplasmic component
MLE07_RS21995	COG1129	ABC transporter
MLE07_RS22000	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS22005	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS22010	COG1609	Transcriptional regulator
MLE07_RS22020	COG0673	inositol 2-dehydrogenase activity
MLE07_RS22080	COG0714	Associated with various cellular activities
MLE07_RS22085	COG3256	nitric oxide reductase
MLE07_RS22100	COG1845	cytochrome c oxidase, subunit III
MLE07_RS22115	COG0163	prenyltransferase activity
MLE07_RS22120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MLE07_RS22125	COG3189	MarR family transcriptional regulator
MLE07_RS22135	COG0826	peptidase U32
MLE07_RS22160	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MLE07_RS22170	COG4459	periplasmic nitrate reductase
MLE07_RS22185	COG0243	molybdopterin cofactor binding
MLE07_RS22195	COG3005	denitrification pathway
MLE07_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS22215	COG1535	isochorismatase
MLE07_RS22215	COG3433	isochorismatase activity
MLE07_RS22220	COG1021	2,3-dihydroxybenzoate-AMP ligase
MLE07_RS22225	COG1169	isochorismate synthase
MLE07_RS22235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MLE07_RS22235	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MLE07_RS22240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MLE07_RS22250	COG2375	cellular response to nickel ion
MLE07_RS22260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS22265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS22270	COG1120	ATPase activity
MLE07_RS22275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLE07_RS22285	COG4774	siderophore transport
MLE07_RS22285	COG1629	transport
MLE07_RS22290	COG1960	acyl-CoA dehydrogenase activity
MLE07_RS22295	COG0583	DNA-binding transcription factor activity
MLE07_RS22300	COG1609	Transcriptional regulator
MLE07_RS22310	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS22320	COG3842	ATPase activity
MLE07_RS22330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MLE07_RS22335	COG0583	DNA-binding transcription factor activity
MLE07_RS22340	COG2814	Major facilitator Superfamily
MLE07_RS22345	COG1473	amidohydrolase
MLE07_RS22350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MLE07_RS22360	COG0747	negative chemotaxis
MLE07_RS22365	COG0601	transmembrane transport
MLE07_RS22370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS22375	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS22380	COG4608	Belongs to the ABC transporter superfamily
MLE07_RS22385	COG0583	DNA-binding transcription factor activity
MLE07_RS22390	COG0747	negative chemotaxis
MLE07_RS22400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS22405	COG0154	amidase activity
MLE07_RS22410	COG0693	protein deglycase activity
MLE07_RS22420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS22425	COG0601	transmembrane transport
MLE07_RS22440	COG1473	amidohydrolase
MLE07_RS22445	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS22450	COG2390	Transcriptional regulator
MLE07_RS22460	COG1175	transmembrane transport
MLE07_RS22465	COG0395	ABC-type sugar transport system, permease component
MLE07_RS22490	COG1069	ribulokinase activity
MLE07_RS22515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MLE07_RS22535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MLE07_RS22540	COG1414	Transcriptional regulator
MLE07_RS22545	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS22555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLE07_RS22560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLE07_RS22565	COG1121	(ABC) transporter
MLE07_RS22570	COG0803	Belongs to the bacterial solute-binding protein 9 family
MLE07_RS22580	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLE07_RS22585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MLE07_RS22590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MLE07_RS22595	COG0471	metal ion transport
MLE07_RS22595	COG3273	potassium ion transport
MLE07_RS22600	COG2827	Endonuclease containing a URI domain
MLE07_RS22605	COG1253	flavin adenine dinucleotide binding
MLE07_RS22610	COG1309	transcriptional regulator
MLE07_RS22630	COG1609	Transcriptional regulator
MLE07_RS22635	COG1070	Carbohydrate kinase
MLE07_RS22640	COG2115	Belongs to the xylose isomerase family
MLE07_RS22650	COG0778	Nitroreductase
MLE07_RS22655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MLE07_RS22660	COG2011	ABC-type metal ion transport system permease component
MLE07_RS22670	COG5001	Diguanylate cyclase
MLE07_RS22670	COG3300	MHYT domain
MLE07_RS22675	COG1054	Belongs to the UPF0176 family
MLE07_RS22685	COG2954	triphosphatase activity
MLE07_RS22690	COG0800	Aldolase
MLE07_RS22710	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
MLE07_RS22750	COG0523	cobalamin synthesis protein
MLE07_RS22760	COG1846	Transcriptional regulator
MLE07_RS22765	COG1609	Transcriptional regulator
MLE07_RS22770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLE07_RS22780	COG3718	enzyme involved in inositol metabolism
MLE07_RS22790	COG3962	Belongs to the TPP enzyme family
MLE07_RS22795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS22810	COG0411	ABC transporter
MLE07_RS22825	COG0683	leucine binding
MLE07_RS22840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS22850	COG0747	negative chemotaxis
MLE07_RS22880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MLE07_RS22885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MLE07_RS22890	COG1126	abc transporter atp-binding protein
MLE07_RS22895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS22900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS22905	COG0765	amino acid transport
MLE07_RS22910	COG0765	amino acid transport
MLE07_RS22915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MLE07_RS22920	COG3485	protocatechuate 3,4-dioxygenase
MLE07_RS22925	COG3485	protocatechuate 3,4-dioxygenase
MLE07_RS22930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MLE07_RS22935	COG2267	carboxylic ester hydrolase activity
MLE07_RS22940	COG0583	DNA-binding transcription factor activity
MLE07_RS22955	COG1414	Transcriptional regulator
MLE07_RS22965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MLE07_RS22970	COG0183	Belongs to the thiolase family
MLE07_RS22975	COG1609	Transcriptional regulator
MLE07_RS22990	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS22995	COG0673	inositol 2-dehydrogenase activity
MLE07_RS23005	COG1609	Transcriptional regulator
MLE07_RS23010	COG0395	ABC-type sugar transport system, permease component
MLE07_RS23015	COG1175	transmembrane transport
MLE07_RS23020	COG3842	ATPase activity
MLE07_RS23030	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MLE07_RS23050	COG2814	Major facilitator Superfamily
MLE07_RS23055	COG4774	siderophore transport
MLE07_RS23060	COG3712	iron ion homeostasis
MLE07_RS23070	COG1940	carbohydrate kinase activity
MLE07_RS23075	COG0584	glycerophosphoryl diester phosphodiesterase
MLE07_RS23080	COG0300	oxidoreductase activity
MLE07_RS23115	COG0667	Aldo Keto reductase
MLE07_RS23120	COG0583	DNA-binding transcription factor activity
MLE07_RS23130	COG1132	(ABC) transporter
MLE07_RS23150	COG2264	protein methyltransferase activity
MLE07_RS23155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLE07_RS23170	COG0463	Glycosyl transferase, family 2
MLE07_RS23190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MLE07_RS23200	COG4106	trans-aconitate 2-methyltransferase activity
MLE07_RS23205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLE07_RS23210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MLE07_RS23220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MLE07_RS23225	COG1091	dTDP-4-dehydrorhamnose reductase activity
MLE07_RS23230	COG1088	dTDP-glucose 4,6-dehydratase activity
MLE07_RS23235	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MLE07_RS23250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS23255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS23260	COG1120	ATPase activity
MLE07_RS23265	COG4774	siderophore transport
MLE07_RS23270	COG0210	DNA helicase
MLE07_RS23280	COG1609	Transcriptional regulator
MLE07_RS23285	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS23285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS23300	COG0395	ABC-type sugar transport system, permease component
MLE07_RS23305	COG3842	ATPase activity
MLE07_RS23315	COG0444	Belongs to the ABC transporter superfamily
MLE07_RS23320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS23325	COG0601	transmembrane transport
MLE07_RS23330	COG2186	Transcriptional regulator
MLE07_RS23350	COG3300	MHYT domain
MLE07_RS23350	COG5001	Diguanylate cyclase
MLE07_RS23355	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS23365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MLE07_RS23375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MLE07_RS23380	COG0306	phosphate transporter
MLE07_RS23385	COG1392	Phosphate transport regulator
MLE07_RS23400	COG1566	PFAM secretion protein HlyD family protein
MLE07_RS23405	COG0745	RESPONSE REGULATOR receiver
MLE07_RS23410	COG2205	protein histidine kinase activity
MLE07_RS23425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MLE07_RS23440	COG4774	siderophore transport
MLE07_RS23450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS23455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLE07_RS23460	COG1120	ATPase activity
MLE07_RS23465	COG0583	DNA-binding transcription factor activity
MLE07_RS23475	COG3119	arylsulfatase activity
MLE07_RS23480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLE07_RS23485	COG3842	ATPase activity
MLE07_RS23490	COG0165	Argininosuccinate lyase
MLE07_RS23495	COG0395	ABC-type sugar transport system, permease component
MLE07_RS23500	COG1175	transmembrane transport
MLE07_RS23505	COG2182	Extracellular solute-binding protein
MLE07_RS23510	COG1940	carbohydrate kinase activity
MLE07_RS23535	COG1486	melibiose metabolic process
MLE07_RS23540	COG0747	negative chemotaxis
MLE07_RS23545	COG0601	transmembrane transport
MLE07_RS23550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS23555	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS23560	COG1486	melibiose metabolic process
MLE07_RS23565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MLE07_RS23570	COG1129	ABC transporter
MLE07_RS23570	COG0842	Transport permease protein
MLE07_RS23575	COG0842	Transport permease protein
MLE07_RS23590	COG0784	Response regulator, receiver
MLE07_RS23595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MLE07_RS23605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS23610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MLE07_RS23625	COG0765	amino acid transport
MLE07_RS23635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS23645	COG3938	Belongs to the proline racemase family
MLE07_RS23660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS23665	COG0765	amino acid transport
MLE07_RS23670	COG0765	amino acid transport
MLE07_RS23680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLE07_RS23695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MLE07_RS23715	COG3383	formate dehydrogenase (NAD+) activity
MLE07_RS23725	COG2223	nitrite transmembrane transporter activity
MLE07_RS23730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS23740	COG2186	Transcriptional regulator
MLE07_RS23745	COG0747	negative chemotaxis
MLE07_RS23750	COG0601	transmembrane transport
MLE07_RS23755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS23760	COG4172	Belongs to the ABC transporter superfamily
MLE07_RS23765	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS23775	COG2186	Transcriptional regulator
MLE07_RS23780	COG0747	negative chemotaxis
MLE07_RS23785	COG0601	transmembrane transport
MLE07_RS23790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLE07_RS23795	COG0405	Gamma-glutamyltransferase
MLE07_RS23805	COG0483	inositol monophosphate 1-phosphatase activity
MLE07_RS23815	COG3842	ATPase activity
MLE07_RS23820	COG0395	ABC-type sugar transport system, permease component
MLE07_RS23840	COG3237	CsbD-like
MLE07_RS23850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MLE07_RS23855	COG3181	Tripartite tricarboxylate transporter family receptor
MLE07_RS23860	COG5265	(ABC) transporter
MLE07_RS23865	COG0488	(ABC) transporter
MLE07_RS23890	COG1049	propionate catabolic process, 2-methylcitrate cycle
MLE07_RS23895	COG0110	maltose O-acetyltransferase activity
MLE07_RS23905	COG1063	alcohol dehydrogenase
MLE07_RS23910	COG3284	Transcriptional regulator
MLE07_RS23930	COG1129	ABC transporter
MLE07_RS23935	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS23940	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS23950	COG0572	uridine kinase
MLE07_RS23955	COG1082	Xylose isomerase domain protein TIM barrel
MLE07_RS23965	COG1126	abc transporter atp-binding protein
MLE07_RS23970	COG0765	amino acid transport
MLE07_RS23975	COG0765	amino acid transport
MLE07_RS23980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS23985	COG3608	succinylglutamate desuccinylase aspartoacylase
MLE07_RS23990	COG0006	proline dipeptidase activity
MLE07_RS23995	COG2423	ornithine cyclodeaminase activity
MLE07_RS24000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MLE07_RS24005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLE07_RS24010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLE07_RS24015	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS24020	COG1522	sequence-specific DNA binding
MLE07_RS24045	COG0596	Alpha beta hydrolase
MLE07_RS24065	COG4178	(ABC) transporter
MLE07_RS24100	COG0640	Transcriptional regulator
MLE07_RS24140	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MLE07_RS24150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MLE07_RS24240	COG1201	RNA secondary structure unwinding
MLE07_RS24270	COG3436	PFAM IS66 Orf2 family protein
MLE07_RS24275	COG4372	Transposase
MLE07_RS24305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLE07_RS24305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLE07_RS24375	COG3657	addiction module killer protein
MLE07_RS24470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MLE07_RS24480	COG0583	DNA-binding transcription factor activity
MLE07_RS24485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MLE07_RS24485	COG1017	nitric oxide dioxygenase activity
MLE07_RS24490	COG0625	glutathione transferase activity
MLE07_RS24620	COG0730	response to heat
MLE07_RS24630	COG0431	NADPH-dependent FMN reductase
MLE07_RS24640	COG0798	PFAM Bile acid sodium symporter
MLE07_RS24655	COG0640	Transcriptional regulator
MLE07_RS24695	COG1192	Involved in chromosome partitioning
MLE07_RS24700	COG1475	DNA binding
MLE07_RS24705	COG1414	Transcriptional regulator
MLE07_RS24745	COG3838	Conjugal transfer protein Trbc
MLE07_RS24750	COG3702	type iv secretory pathway
MLE07_RS24760	COG3451	type IV secretory pathway VirB4
MLE07_RS24775	COG3704	protein secretion by the type IV secretion system
MLE07_RS24785	COG3736	Type IV secretory pathway, component VirB8
MLE07_RS24790	COG3504	Conjugal transfer protein
MLE07_RS24795	COG2948	multi-organism process
MLE07_RS24800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MLE07_RS24905	COG3831	ATPase activity
MLE07_RS24915	COG3505	Type IV secretory pathway VirD4
MLE07_RS24955	COG2197	response regulator
MLE07_RS24960	COG0604	alcohol dehydrogenase
MLE07_RS24960	COG3321	synthase
MLE07_RS24980	COG2188	Transcriptional regulator
MLE07_RS24985	COG0765	amino acid transport
MLE07_RS24990	COG0765	amino acid transport
MLE07_RS24995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS25000	COG1126	abc transporter atp-binding protein
MLE07_RS25015	COG0300	oxidoreductase activity
MLE07_RS25030	COG0840	transmembrane signaling receptor activity
MLE07_RS25045	COG5001	Diguanylate cyclase
MLE07_RS25045	COG3300	MHYT domain
MLE07_RS25050	COG0840	transmembrane signaling receptor activity
MLE07_RS25055	COG2207	Transcriptional regulator
MLE07_RS25105	COG2831	hemolysin activation secretion protein
MLE07_RS25130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MLE07_RS25145	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLE07_RS25145	COG0824	Thioesterase
MLE07_RS25150	COG4770	biotin carboxylase activity
MLE07_RS25155	COG3842	ATPase activity
MLE07_RS25170	COG0318	PFAM AMP-dependent synthetase and ligase
MLE07_RS25180	COG1178	ABC-type Fe3 transport system permease component
MLE07_RS25195	COG2030	dehydratase
MLE07_RS25200	COG1028	Short-chain dehydrogenase reductase Sdr
MLE07_RS25230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MLE07_RS25245	COG2086	electron transfer activity
MLE07_RS25250	COG1802	Transcriptional regulator
MLE07_RS25255	COG0277	FAD linked oxidase domain protein
MLE07_RS25260	COG1126	abc transporter atp-binding protein
MLE07_RS25265	COG0765	amino acid transport
MLE07_RS25275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS25280	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS25285	COG0395	ABC-type sugar transport system, permease component
MLE07_RS25290	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLE07_RS25300	COG3842	ATPase activity
MLE07_RS25305	COG1473	amidohydrolase
MLE07_RS25310	COG1304	FMN binding
MLE07_RS25335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLE07_RS25340	COG1396	sequence-specific DNA binding
MLE07_RS25345	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MLE07_RS25370	COG0395	ABC-type sugar transport system, permease component
MLE07_RS25380	COG0583	DNA-binding transcription factor activity
MLE07_RS25440	COG3534	alpha-L-arabinofuranosidase
MLE07_RS25445	COG4603	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS25450	COG4603	Belongs to the binding-protein-dependent transport system permease family
MLE07_RS25455	COG3845	ABC transporter
MLE07_RS25485	COG1760	l-serine dehydratase
MLE07_RS25490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MLE07_RS25500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MLE07_RS25500	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLE07_RS25510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS25515	COG1917	Cupin 2, conserved barrel domain protein
MLE07_RS25515	COG4977	sequence-specific DNA binding
MLE07_RS25530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLE07_RS25535	COG1012	belongs to the aldehyde dehydrogenase family
MLE07_RS25540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS25555	COG4176	ABC-type proline glycine betaine transport system permease component
MLE07_RS25560	COG4176	ABC-type proline glycine betaine transport system permease component
MLE07_RS25575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MLE07_RS25600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLE07_RS25635	COG1609	Transcriptional regulator
MLE07_RS25645	COG0583	DNA-binding transcription factor activity
MLE07_RS25740	COG2826	transposase and inactivated derivatives, IS30 family
MLE07_RS25770	COG0431	NADPH-dependent FMN reductase
MLE07_RS25795	COG0640	Transcriptional regulator
MLE07_RS25810	COG0640	Transcriptional regulator
MLE07_RS25815	COG1475	DNA binding
MLE07_RS25820	COG1192	Involved in chromosome partitioning
MLE07_RS25830	COG4962	Type ii secretion system protein e
MLE07_RS25845	COG3451	type IV secretory pathway VirB4
MLE07_RS25850	COG5314	conjugation
MLE07_RS25860	COG3846	protein secretion by the type IV secretion system
MLE07_RS25865	COG3701	Conjugal transfer protein
MLE07_RS25895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MLE07_RS25900	COG1335	isochorismatase
MLE07_RS25905	COG4977	sequence-specific DNA binding
MLE07_RS25930	COG0402	S-adenosylhomocysteine deaminase activity
MLE07_RS25935	COG1228	amidohydrolase
MLE07_RS25940	COG2986	histidine ammonia-lyase
MLE07_RS25950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MLE07_RS25965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MLE07_RS25980	COG0765	amino acid transport
MLE07_RS25995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLE07_RS26010	COG2271	Major facilitator Superfamily
MLE07_RS26025	COG2204	response regulator
MLE07_RS26030	COG0784	Response regulator, receiver
MLE07_RS26030	COG2205	protein histidine kinase activity
MLE07_RS26035	COG2197	response regulator
MLE07_RS26060	COG4977	sequence-specific DNA binding
MLE07_RS26085	COG2271	Major facilitator Superfamily
MLE07_RS26090	COG4948	Mandelate Racemase Muconate Lactonizing
MLE07_RS26105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MLE07_RS26110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MLE07_RS26155	COG2205	protein histidine kinase activity
MLE07_RS26160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MLE07_RS26215	COG3831	ATPase activity
MLE07_RS26220	COG0776	regulation of translation
MLE07_RS26235	COG5489	Protein of unknown function (DUF736)
MLE07_RS26250	COG2824	Alkylphosphonate utilization operon protein PhnA
MLE07_RS26275	COG1475	DNA binding
MLE07_RS26340	COG0640	Transcriptional regulator
MLE07_RS26360	COG3447	MASE1 domain protein
MLE07_RS26360	COG5001	Diguanylate cyclase
MLE07_RS26360	COG5002	protein histidine kinase activity
MLE07_RS26390	COG3300	MHYT domain
MLE07_RS26390	COG5001	Diguanylate cyclase
MLE07_RS26400	COG4585	Histidine kinase
MLE07_RS26405	COG2197	response regulator
MLE07_RS26420	COG1280	lysine exporter protein (LysE YggA)
MLE07_RS26450	COG3077	Addiction module antitoxin, RelB DinJ family
MLE07_RS26475	COG0071	Belongs to the small heat shock protein (HSP20) family