locus-tag	class	description
FY145_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY145_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY145_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY145_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY145_RS00025	COG1420	regulation of RNA biosynthetic process
FY145_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY145_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY145_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY145_RS00050	COG1137	ATPase activity
FY145_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY145_RS00065	COG0616	signal peptide processing
FY145_RS00070	COG0776	regulation of translation
FY145_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY145_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY145_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY145_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY145_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY145_RS00115	COG0728	peptidoglycan biosynthetic process
FY145_RS00125	COG0180	Tryptophanyl-tRNA synthetase
FY145_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY145_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
FY145_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY145_RS00165	COG1702	phosphate starvation-inducible protein PhoH
FY145_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY145_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY145_RS00185	COG1396	sequence-specific DNA binding
FY145_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY145_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY145_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS00210	COG0242	peptide deformylase activity
FY145_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY145_RS00220	COG0101	tRNA pseudouridine synthase activity
FY145_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY145_RS00235	COG2171	N-acyltransferase activity
FY145_RS00245	COG0840	transmembrane signaling receptor activity
FY145_RS00250	COG1957	nucleoside hydrolase
FY145_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY145_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY145_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY145_RS00295	COG0706	membrane insertase activity
FY145_RS00300	COG0594	ribonuclease P activity
FY145_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY145_RS00310	COG0840	transmembrane signaling receptor activity
FY145_RS00325	COG2226	methyltransferase
FY145_RS00330	COG3842	ATPase activity
FY145_RS00335	COG1175	transmembrane transport
FY145_RS00340	COG0395	ABC-type sugar transport system, permease component
FY145_RS00355	COG0427	acetyl-CoA hydrolase
FY145_RS00365	COG3938	Belongs to the proline racemase family
FY145_RS00370	COG0418	dihydroorotase activity
FY145_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY145_RS00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY145_RS00400	COG0166	Belongs to the GPI family
FY145_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
FY145_RS00410	COG3842	ATPase activity
FY145_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
FY145_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY145_RS00425	COG4774	siderophore transport
FY145_RS00470	COG2326	polyphosphate kinase activity
FY145_RS00475	COG5002	protein histidine kinase activity
FY145_RS00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY145_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
FY145_RS00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY145_RS00500	COG0704	Plays a role in the regulation of phosphate uptake
FY145_RS00505	COG0745	RESPONSE REGULATOR receiver
FY145_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY145_RS00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY145_RS00530	COG2967	ApaG domain
FY145_RS00540	COG0717	Belongs to the dCTP deaminase family
FY145_RS00550	COG0582	viral genome integration into host DNA
FY145_RS00575	COG0419	ATPase involved in DNA repair
FY145_RS00595	COG1396	sequence-specific DNA binding
FY145_RS00635	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FY145_RS00640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY145_RS00690	COG0167	dihydroorotate dehydrogenase activity
FY145_RS00725	COG1959	2 iron, 2 sulfur cluster binding
FY145_RS00730	COG1201	RNA secondary structure unwinding
FY145_RS00760	COG1960	acyl-CoA dehydrogenase activity
FY145_RS00765	COG0183	Belongs to the thiolase family
FY145_RS00775	COG1024	Enoyl-CoA hydratase
FY145_RS00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY145_RS00800	COG1320	monovalent cation:proton antiporter activity
FY145_RS00805	COG2212	antiporter activity
FY145_RS00810	COG1863	multisubunit Na H antiporter MnhE subunit
FY145_RS00815	COG0651	ATP synthesis coupled electron transport
FY145_RS00820	COG1006	Multisubunit Na H antiporter MnhC subunit
FY145_RS00825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY145_RS00825	COG2111	Na H antiporter
FY145_RS00835	COG0840	transmembrane signaling receptor activity
FY145_RS00845	COG0745	RESPONSE REGULATOR receiver
FY145_RS00850	COG0643	Histidine kinase
FY145_RS00850	COG2198	Histidine kinase
FY145_RS00855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY145_RS00860	COG2201	protein-glutamate methylesterase activity
FY145_RS00865	COG0745	RESPONSE REGULATOR receiver
FY145_RS00870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY145_RS00880	COG1766	The M ring may be actively involved in energy transduction
FY145_RS00885	COG2771	luxR family
FY145_RS00895	COG0840	transmembrane signaling receptor activity
FY145_RS00895	COG2972	Histidine kinase
FY145_RS00900	COG2205	protein histidine kinase activity
FY145_RS00900	COG0784	Response regulator, receiver
FY145_RS00900	COG2198	Histidine kinase
FY145_RS00905	COG1970	mechanosensitive ion channel activity
FY145_RS00910	COG0436	Aminotransferase
FY145_RS00925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY145_RS00930	COG0424	maF-like protein
FY145_RS00935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY145_RS00945	COG5328	Belongs to the UPF0262 family
FY145_RS00950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY145_RS00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY145_RS01095	COG3728	DNA packaging
FY145_RS01095	COG5484	DNA packaging
FY145_RS01230	COG0582	viral genome integration into host DNA
FY145_RS01240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY145_RS01250	COG1338	Plays a role in the flagellum-specific transport system
FY145_RS01260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY145_RS01270	COG1706	bacterial-type flagellum-dependent cell motility
FY145_RS01275	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY145_RS01280	COG4786	Flagellar basal body rod
FY145_RS01285	COG1677	Flagellar hook-basal body complex protein FliE
FY145_RS01290	COG1558	bacterial-type flagellum-dependent cell motility
FY145_RS01295	COG1815	bacterial-type flagellum-dependent cell motility
FY145_RS01305	COG1157	protein secretion by the type III secretion system
FY145_RS01310	COG4786	Flagellar basal body rod
FY145_RS01320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY145_RS01325	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY145_RS01330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY145_RS01335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY145_RS01340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY145_RS01360	COG1360	Flagellar Motor Protein
FY145_RS01405	COG5443	negative regulation of bacterial-type flagellum assembly
FY145_RS01410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY145_RS01420	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY145_RS01460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY145_RS01465	COG1609	Transcriptional regulator
FY145_RS01470	COG1653	transport
FY145_RS01475	COG1175	transmembrane transport
FY145_RS01480	COG0395	ABC-type sugar transport system, permease component
FY145_RS01485	COG0366	Alpha amylase catalytic
FY145_RS01490	COG3842	ATPase activity
FY145_RS01505	COG0129	dihydroxy-acid dehydratase activity
FY145_RS01510	COG0363	glucosamine-6-phosphate deaminase activity
FY145_RS01515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY145_RS01520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS01530	COG2081	HI0933 family
FY145_RS01550	COG2224	Isocitrate lyase
FY145_RS01565	COG3842	ATPase activity
FY145_RS01570	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS01575	COG1177	transmembrane transport
FY145_RS01590	COG2205	protein histidine kinase activity
FY145_RS01600	COG0248	Ppx GppA phosphatase
FY145_RS01605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY145_RS01610	COG0477	Major facilitator Superfamily
FY145_RS01640	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY145_RS01645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY145_RS01655	COG0142	geranyltranstransferase activity
FY145_RS01680	COG0752	glycyl-tRNA synthetase alpha subunit
FY145_RS01690	COG1704	LemA family
FY145_RS01695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY145_RS01705	COG0751	glycine-tRNA ligase activity
FY145_RS01710	COG1683	Conserved Protein
FY145_RS01715	COG0840	transmembrane signaling receptor activity
FY145_RS01725	COG0151	Belongs to the GarS family
FY145_RS01730	COG2183	response to ionizing radiation
FY145_RS01735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY145_RS01760	COG0583	DNA-binding transcription factor activity
FY145_RS01780	COG0306	phosphate transporter
FY145_RS01790	COG0561	phosphatase activity
FY145_RS01795	COG0438	transferase activity, transferring glycosyl groups
FY145_RS01800	COG2186	Transcriptional regulator
FY145_RS01815	COG0583	DNA-binding transcription factor activity
FY145_RS01820	COG0277	FAD linked oxidase domain protein
FY145_RS01825	COG0277	FAD linked oxidase domain protein
FY145_RS01830	COG0247	lactate metabolic process
FY145_RS01840	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS01845	COG2818	Glycosylase
FY145_RS01855	COG2855	membrane
FY145_RS01860	COG0583	DNA-binding transcription factor activity
FY145_RS01890	COG0124	histidyl-tRNA synthetase
FY145_RS01900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY145_RS01905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY145_RS01910	COG2259	Doxx family
FY145_RS01920	COG0459	protein refolding
FY145_RS01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY145_RS01935	COG0196	riboflavin kinase activity
FY145_RS01940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY145_RS01950	COG0590	tRNA wobble adenosine to inosine editing
FY145_RS01955	COG1187	pseudouridine synthase activity
FY145_RS01960	COG0742	ribosomal rna small subunit methyltransferase
FY145_RS01965	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY145_RS01975	COG0312	modulator of DNA gyrase
FY145_RS01980	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS01990	COG1519	Transferase
FY145_RS02000	COG1663	tetraacyldisaccharide 4'-kinase activity
FY145_RS02010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY145_RS02015	COG0745	RESPONSE REGULATOR receiver
FY145_RS02020	COG5001	Diguanylate cyclase
FY145_RS02020	COG3300	MHYT domain
FY145_RS02025	COG3386	PFAM SMP-30 Gluconolaconase
FY145_RS02030	COG0800	Aldolase
FY145_RS02035	COG3734	2-keto-3-deoxy-galactonokinase
FY145_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS02045	COG1414	Transcriptional regulator
FY145_RS02050	COG2197	response regulator
FY145_RS02065	COG0598	Magnesium transport protein CorA
FY145_RS02070	COG3158	transport of potassium into the cell
FY145_RS02085	COG0356	it plays a direct role in the translocation of protons across the membrane
FY145_RS02095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY145_RS02100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY145_RS02115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY145_RS02135	COG0009	L-threonylcarbamoyladenylate synthase
FY145_RS02145	COG4638	Rieske (2fe-2S)
FY145_RS02170	COG1960	acyl-CoA dehydrogenase activity
FY145_RS02185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY145_RS02190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY145_RS02195	COG0840	transmembrane signaling receptor activity
FY145_RS02205	COG1522	sequence-specific DNA binding
FY145_RS02230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY145_RS02235	COG1741	Belongs to the pirin family
FY145_RS02240	COG1722	exodeoxyribonuclease VII activity
FY145_RS02245	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY145_RS02250	COG1268	BioY protein
FY145_RS02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY145_RS02260	COG1122	ATPase activity
FY145_RS02265	COG3214	Protein conserved in bacteria
FY145_RS02270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY145_RS02270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY145_RS02275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY145_RS02295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY145_RS02310	COG0259	pyridoxamine-phosphate oxidase activity
FY145_RS02340	COG0312	modulator of DNA gyrase
FY145_RS02355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY145_RS02360	COG0109	protoheme IX farnesyltransferase activity
FY145_RS02370	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY145_RS02385	COG3346	SURF1 family
FY145_RS02390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY145_RS02395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY145_RS02400	COG0328	RNA-DNA hybrid ribonuclease activity
FY145_RS02410	COG0678	peroxiredoxin activity
FY145_RS02410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY145_RS02420	COG1678	Uncharacterized ACR, COG1678
FY145_RS02425	COG3237	CsbD-like
FY145_RS02435	COG3300	MHYT domain
FY145_RS02435	COG5001	Diguanylate cyclase
FY145_RS02440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY145_RS02445	COG0612	Peptidase, M16
FY145_RS02470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY145_RS02475	COG1802	Transcriptional regulator
FY145_RS02490	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY145_RS02495	COG3609	addiction module antidote protein, CC2985 family
FY145_RS02500	COG3668	Plasmid stabilization system
FY145_RS02510	COG1194	a g-specific adenine glycosylase
FY145_RS02525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY145_RS02530	COG1196	nuclear chromosome segregation
FY145_RS02535	COG2514	catechol 2,3-dioxygenase activity
FY145_RS02540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY145_RS02540	COG0574	Belongs to the PEP-utilizing enzyme family
FY145_RS02550	COG1823	symporter activity
FY145_RS02575	COG0579	oxidoreductase
FY145_RS02590	COG2895	sulfate adenylyltransferase (ATP) activity
FY145_RS02595	COG0175	sulfate reduction
FY145_RS02600	COG0175	sulfate reduction
FY145_RS02605	COG1959	2 iron, 2 sulfur cluster binding
FY145_RS02610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY145_RS02615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY145_RS02620	COG4208	sulfate ABC transporter
FY145_RS02625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY145_RS02635	COG2199	diguanylate cyclase activity
FY145_RS02635	COG2200	EAL domain
FY145_RS02635	COG2203	Gaf domain
FY145_RS02645	COG1309	transcriptional regulator
FY145_RS02650	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS02655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY145_RS02685	COG0625	glutathione transferase activity
FY145_RS02695	COG0477	Major facilitator Superfamily
FY145_RS02705	COG3657	addiction module killer protein
FY145_RS02715	COG1793	dna ligase
FY145_RS02735	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS02740	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS02745	COG1846	Transcriptional regulator
FY145_RS02750	COG1764	response to oxidative stress
FY145_RS02765	COG0488	(ABC) transporter
FY145_RS02800	COG4221	oxidoreductase activity
FY145_RS02815	COG0433	COG0433 Predicted ATPase
FY145_RS02825	COG1733	regulation of RNA biosynthetic process
FY145_RS02830	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY145_RS02845	COG0656	L-ascorbic acid biosynthetic process
FY145_RS02850	COG3781	membrane
FY145_RS02855	COG2378	regulation of single-species biofilm formation
FY145_RS02865	COG4106	trans-aconitate 2-methyltransferase activity
FY145_RS02870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY145_RS02875	COG0840	transmembrane signaling receptor activity
FY145_RS02880	COG0583	DNA-binding transcription factor activity
FY145_RS02895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY145_RS02915	COG3909	cytochrome
FY145_RS02920	COG2010	Cytochrome c
FY145_RS02955	COG0789	Transcriptional regulator
FY145_RS02980	COG0517	IMP dehydrogenase activity
FY145_RS02980	COG4175	Glycine betaine
FY145_RS02985	COG4176	ABC-type proline glycine betaine transport system permease component
FY145_RS03010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS03020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY145_RS03020	COG2169	Transcriptional regulator
FY145_RS03030	COG2514	catechol 2,3-dioxygenase activity
FY145_RS03050	COG1272	protein, Hemolysin III
FY145_RS03060	COG1280	lysine exporter protein (LysE YggA)
FY145_RS03065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY145_RS03070	COG2111	Na H antiporter
FY145_RS03070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY145_RS03075	COG2111	Na H antiporter
FY145_RS03080	COG1006	Multisubunit Na H antiporter MnhC subunit
FY145_RS03085	COG0651	ATP synthesis coupled electron transport
FY145_RS03090	COG1863	multisubunit Na H antiporter MnhE subunit
FY145_RS03095	COG2212	antiporter activity
FY145_RS03100	COG1320	monovalent cation:proton antiporter activity
FY145_RS03105	COG4957	zinc ion binding
FY145_RS03120	COG2166	iron-sulfur cluster assembly
FY145_RS03130	COG2205	protein histidine kinase activity
FY145_RS03175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY145_RS03180	COG2983	Belongs to the UPF0260 family
FY145_RS03195	COG2217	Heavy metal translocating P-type atpase
FY145_RS03225	COG2814	Major facilitator Superfamily
FY145_RS03235	COG1621	beta-fructofuranosidase activity
FY145_RS03240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY145_RS03290	COG4695	Portal protein
FY145_RS03395	COG4235	cytochrome complex assembly
FY145_RS03400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY145_RS03405	COG1138	Cytochrome C-type biogenesis protein
FY145_RS03410	COG3088	subunit of a heme lyase
FY145_RS03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY145_RS03420	COG0745	RESPONSE REGULATOR receiver
FY145_RS03425	COG2205	protein histidine kinase activity
FY145_RS03430	COG3011	Protein conserved in bacteria
FY145_RS03435	COG3713	MltA-interacting MipA family protein
FY145_RS03440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY145_RS03445	COG2202	Pas domain
FY145_RS03445	COG2205	protein histidine kinase activity
FY145_RS03455	COG0308	aminopeptidase N
FY145_RS03460	COG0697	spore germination
FY145_RS03475	COG0443	Heat shock 70 kDa protein
FY145_RS03510	COG0604	alcohol dehydrogenase
FY145_RS03515	COG1733	regulation of RNA biosynthetic process
FY145_RS03520	COG1968	undecaprenyl-diphosphatase activity
FY145_RS03525	COG2239	Acts as a magnesium transporter
FY145_RS03530	COG2814	Major facilitator Superfamily
FY145_RS03555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY145_RS03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY145_RS03630	COG0741	lytic transglycosylase activity
FY145_RS03635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS03640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY145_RS03645	COG0840	transmembrane signaling receptor activity
FY145_RS03655	COG1758	RNA polymerase activity
FY145_RS03675	COG0736	holo-[acyl-carrier-protein] synthase activity
FY145_RS03680	COG0681	Belongs to the peptidase S26 family
FY145_RS03685	COG0571	ribonuclease III activity
FY145_RS03690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY145_RS03700	COG0784	Response regulator, receiver
FY145_RS03705	COG1381	Involved in DNA repair and RecF pathway recombination
FY145_RS03715	COG2226	methyltransferase
FY145_RS03725	COG1418	mRNA catabolic process
FY145_RS03735	COG0346	lactoylglutathione lyase activity
FY145_RS03750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS03755	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY145_RS03760	COG0668	transmembrane transport
FY145_RS03770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY145_RS03800	COG1742	UPF0060 membrane protein
FY145_RS03820	COG1183	phosphatidylcholine synthase activity
FY145_RS03825	COG0688	phosphatidylethanolamine metabolic process
FY145_RS03830	COG5265	(ABC) transporter
FY145_RS03870	COG2852	Protein conserved in bacteria
FY145_RS03875	COG0215	cysteine-tRNA ligase activity
FY145_RS03880	COG4221	oxidoreductase activity
FY145_RS03885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY145_RS03890	COG1286	toxin biosynthetic process
FY145_RS03905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY145_RS03915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY145_RS03925	COG0305	Participates in initiation and elongation during chromosome replication
FY145_RS03945	COG0359	binds to the 23S rRNA
FY145_RS03955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY145_RS03960	COG0360	Binds together with S18 to 16S ribosomal RNA
FY145_RS03970	COG0667	Aldo Keto reductase
FY145_RS03975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY145_RS03985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY145_RS03990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY145_RS04000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY145_RS04005	COG1561	YicC-like family, N-terminal region
FY145_RS04010	COG0194	GDP metabolic process
FY145_RS04025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY145_RS04030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY145_RS04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY145_RS04055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY145_RS04075	COG2203	Gaf domain
FY145_RS04075	COG3706	GGDEF domain
FY145_RS04075	COG5001	Diguanylate cyclase
FY145_RS04075	COG4251	negative regulation of phosphorylation
FY145_RS04080	COG5001	Diguanylate cyclase
FY145_RS04080	COG3300	MHYT domain
FY145_RS04085	COG4191	Histidine kinase
FY145_RS04090	COG4566	intracellular signal transduction
FY145_RS04100	COG0488	(ABC) transporter
FY145_RS04105	COG3706	GGDEF domain
FY145_RS04115	COG0105	UTP biosynthetic process
FY145_RS04135	COG0314	molybdopterin synthase activity
FY145_RS04145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY145_RS04150	COG0322	excinuclease ABC activity
FY145_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS04180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY145_RS04185	COG0243	molybdopterin cofactor binding
FY145_RS04200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY145_RS04205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY145_RS04210	COG2226	methyltransferase
FY145_RS04215	COG0628	permease
FY145_RS04225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY145_RS04230	COG0248	Ppx GppA phosphatase
FY145_RS04255	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY145_RS04265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY145_RS04270	COG0477	Major facilitator Superfamily
FY145_RS04275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY145_RS04285	COG0840	transmembrane signaling receptor activity
FY145_RS04290	COG0659	secondary active sulfate transmembrane transporter activity
FY145_RS04300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY145_RS04305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY145_RS04315	COG0113	porphobilinogen synthase activity
FY145_RS04335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY145_RS04340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY145_RS04345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY145_RS04345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY145_RS04355	COG1280	lysine exporter protein (LysE YggA)
FY145_RS04360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY145_RS04365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY145_RS04370	COG2814	Major facilitator Superfamily
FY145_RS04375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY145_RS04395	COG0416	fatty acid biosynthetic process
FY145_RS04400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY145_RS04405	COG0776	regulation of translation
FY145_RS04440	COG0601	transmembrane transport
FY145_RS04445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS04450	COG0444	Belongs to the ABC transporter superfamily
FY145_RS04460	COG0747	negative chemotaxis
FY145_RS04470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY145_RS04475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY145_RS04490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY145_RS04495	COG0583	DNA-binding transcription factor activity
FY145_RS04500	COG0737	Belongs to the 5'-nucleotidase family
FY145_RS04520	COG2897	thiosulfate sulfurtransferase activity
FY145_RS04535	COG0415	Belongs to the DNA photolyase family
FY145_RS04545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY145_RS04575	COG3932	Exopolysaccharide synthesis, ExoD
FY145_RS04580	COG1238	metal cluster binding
FY145_RS04655	COG1612	heme a metabolic process
FY145_RS04665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY145_RS04670	COG0010	Belongs to the arginase family
FY145_RS04675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY145_RS04680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY145_RS04690	COG1832	CoA-binding protein
FY145_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS04720	COG2124	cytochrome p450
FY145_RS04725	COG2199	diguanylate cyclase activity
FY145_RS04730	COG0740	serine-type endopeptidase activity
FY145_RS04735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY145_RS04740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY145_RS04750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY145_RS04780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY145_RS04785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY145_RS04790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY145_RS04800	COG0649	NAD binding
FY145_RS04810	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY145_RS04815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY145_RS04825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY145_RS04830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY145_RS04840	COG0713	ATP synthesis coupled electron transport
FY145_RS04855	COG1007	ATP synthesis coupled electron transport
FY145_RS04860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY145_RS04860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY145_RS04875	COG0442	prolyl-tRNA aminoacylation
FY145_RS04885	COG1136	(ABC) transporter
FY145_RS04900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY145_RS04920	COG0784	Response regulator, receiver
FY145_RS04930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY145_RS04935	COG0477	Major facilitator Superfamily
FY145_RS04950	COG0557	exoribonuclease II activity
FY145_RS04955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY145_RS04965	COG0758	DNA mediated transformation
FY145_RS04970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY145_RS04980	COG0540	Belongs to the ATCase OTCase family
FY145_RS04995	COG1960	acyl-CoA dehydrogenase activity
FY145_RS05000	COG0456	acetyltransferase
FY145_RS05020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY145_RS05025	COG2824	Alkylphosphonate utilization operon protein PhnA
FY145_RS05030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY145_RS05035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY145_RS05040	COG0154	amidase activity
FY145_RS05045	COG0456	acetyltransferase
FY145_RS05050	COG3811	Belongs to the UPF0386 family
FY145_RS05065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY145_RS05095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY145_RS05100	COG0439	Biotin carboxylase
FY145_RS05105	COG0511	ligase activity, forming carbon-carbon bonds
FY145_RS05110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY145_RS05120	COG0436	Aminotransferase
FY145_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS05145	COG1530	ribonuclease E activity
FY145_RS05155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY145_RS05175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY145_RS05180	COG0384	phenazine biosynthesis protein PhzF
FY145_RS05200	COG0633	Ferredoxin
FY145_RS05210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY145_RS05215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY145_RS05220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY145_RS05230	COG3768	UPF0283 membrane protein
FY145_RS05235	COG3106	COG3106 Predicted ATPase
FY145_RS05265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY145_RS05300	COG0537	adenosine 5'-monophosphoramidase activity
FY145_RS05330	COG0052	Belongs to the universal ribosomal protein uS2 family
FY145_RS05335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY145_RS05340	COG0528	UMP kinase activity
FY145_RS05345	COG0233	cytoplasmic translational termination
FY145_RS05350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY145_RS05360	COG0750	zinc metalloprotease
FY145_RS05365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY145_RS05370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY145_RS05375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY145_RS05380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY145_RS05385	COG3494	Protein of unknown function (DUF1009)
FY145_RS05390	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY145_RS05395	COG2186	Transcriptional regulator
FY145_RS05405	COG0765	amino acid transport
FY145_RS05410	COG0765	amino acid transport
FY145_RS05420	COG0372	Belongs to the citrate synthase family
FY145_RS05435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY145_RS05460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FY145_RS05465	COG1459	type II secretion system
FY145_RS05520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY145_RS05525	COG0148	phosphopyruvate hydratase activity
FY145_RS05535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY145_RS05540	COG0022	dehydrogenase e1 component
FY145_RS05540	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY145_RS05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY145_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY145_RS05565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY145_RS05570	COG0697	spore germination
FY145_RS05590	COG2867	negative regulation of translational initiation
FY145_RS05595	COG1546	Belongs to the CinA family
FY145_RS05600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY145_RS05600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY145_RS05610	COG3852	Histidine kinase
FY145_RS05615	COG2204	response regulator
FY145_RS05620	COG5000	phosphorelay sensor kinase activity
FY145_RS05625	COG2204	response regulator
FY145_RS05635	COG1923	regulation of RNA biosynthetic process
FY145_RS05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY145_RS05645	COG3956	TIGRFAM MazG family protein
FY145_RS05655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY145_RS05655	COG1648	precorrin-2 dehydrogenase activity
FY145_RS05695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY145_RS05695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY145_RS05700	COG0509	glycine decarboxylation via glycine cleavage system
FY145_RS05705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY145_RS05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY145_RS05735	COG0564	pseudouridine synthase activity
FY145_RS05755	COG0251	oxidation-reduction process
FY145_RS05760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY145_RS05770	COG1671	Belongs to the UPF0178 family
FY145_RS05785	COG0450	alkyl hydroperoxide reductase
FY145_RS05790	COG0625	glutathione transferase activity
FY145_RS05810	COG0431	NADPH-dependent FMN reductase
FY145_RS05820	COG0798	PFAM Bile acid sodium symporter
FY145_RS05825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY145_RS05840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY145_RS05840	COG0321	lipoyl(octanoyl) transferase activity
FY145_RS05845	COG0084	hydrolase, TatD family'
FY145_RS05850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY145_RS05860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY145_RS05915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY145_RS05920	COG2095	MarC family integral membrane protein
FY145_RS05925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY145_RS05925	COG0517	IMP dehydrogenase activity
FY145_RS05925	COG0617	tRNA 3'-terminal CCA addition
FY145_RS05935	COG0629	single-stranded DNA binding
FY145_RS05940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY145_RS05950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY145_RS05970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY145_RS05975	COG1121	(ABC) transporter
FY145_RS05995	COG0667	Aldo Keto reductase
FY145_RS06005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY145_RS06085	COG2239	Acts as a magnesium transporter
FY145_RS06090	COG0243	molybdopterin cofactor binding
FY145_RS06100	COG0242	peptide deformylase activity
FY145_RS06115	COG2202	Pas domain
FY145_RS06115	COG2205	protein histidine kinase activity
FY145_RS06125	COG0321	lipoyl(octanoyl) transferase activity
FY145_RS06130	COG1064	alcohol dehydrogenase
FY145_RS06160	COG1862	Preprotein translocase
FY145_RS06180	COG2124	cytochrome p450
FY145_RS06195	COG0596	Alpha beta hydrolase
FY145_RS06205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY145_RS06210	COG0626	cystathionine gamma-synthase activity
FY145_RS06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS06220	COG4597	amino acid ABC transporter
FY145_RS06225	COG0765	amino acid transport
FY145_RS06230	COG1126	abc transporter atp-binding protein
FY145_RS06245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY145_RS06260	COG0436	Aminotransferase
FY145_RS06290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY145_RS06300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY145_RS06305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY145_RS06310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY145_RS06325	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY145_RS06330	COG1489	DNA binding
FY145_RS06335	COG0024	Methionine aminopeptidase
FY145_RS06340	COG2003	Belongs to the UPF0758 family
FY145_RS06355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY145_RS06380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY145_RS06385	COG0546	phosphoglycolate phosphatase activity
FY145_RS06395	COG0114	fumarate hydratase activity
FY145_RS06405	COG0504	CTP synthase activity
FY145_RS06415	COG0149	triose-phosphate isomerase activity
FY145_RS06425	COG0187	DNA topoisomerase II activity
FY145_RS06435	COG0740	serine-type endopeptidase activity
FY145_RS06445	COG0640	Transcriptional regulator
FY145_RS06450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY145_RS06455	COG0745	RESPONSE REGULATOR receiver
FY145_RS06470	COG3264	Mechanosensitive ion channel
FY145_RS06470	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY145_RS06535	COG1127	ABC transporter
FY145_RS06540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY145_RS06545	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS06555	COG0280	phosphate acetyltransferase
FY145_RS06555	COG0281	malic enzyme
FY145_RS06565	COG0778	Nitroreductase
FY145_RS06570	COG0823	Involved in the tonB-independent uptake of proteins
FY145_RS06585	COG1368	sulfuric ester hydrolase activity
FY145_RS06610	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY145_RS06630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY145_RS06655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY145_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
FY145_RS06680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY145_RS06680	COG0512	Glutamine amidotransferase of anthranilate synthase
FY145_RS06685	COG0343	queuine tRNA-ribosyltransferase activity
FY145_RS06690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY145_RS06705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY145_RS06725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY145_RS06730	COG0134	indole-3-glycerol-phosphate synthase activity
FY145_RS06735	COG0315	cyclic pyranopterin monophosphate synthase activity
FY145_RS06740	COG0303	'Molybdopterin
FY145_RS06745	COG3706	GGDEF domain
FY145_RS06755	COG0475	glutathione-regulated potassium exporter activity
FY145_RS06755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY145_RS06765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY145_RS06775	COG2814	Major facilitator Superfamily
FY145_RS06780	COG0746	molybdenum cofactor guanylyltransferase activity
FY145_RS06785	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY145_RS06790	COG0739	heme binding
FY145_RS06795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY145_RS06800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY145_RS06805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY145_RS06810	COG0805	protein transport
FY145_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY145_RS06820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY145_RS06825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY145_RS06830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY145_RS06835	COG1472	Belongs to the glycosyl hydrolase 3 family
FY145_RS06845	COG0018	arginyl-trna synthetase
FY145_RS06850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY145_RS06875	COG0525	valine-tRNA ligase activity
FY145_RS06885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY145_RS07025	COG1525	nuclease
FY145_RS07100	COG3567	Phage-associated protein, HI1409 family
FY145_RS07150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY145_RS07175	COG0305	Participates in initiation and elongation during chromosome replication
FY145_RS07175	COG1372	Participates in initiation and elongation during chromosome replication
FY145_RS07335	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY145_RS07340	COG1058	Belongs to the CinA family
FY145_RS07340	COG1546	Belongs to the CinA family
FY145_RS07345	COG0589	response to stress
FY145_RS07350	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY145_RS07365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY145_RS07375	COG0640	Transcriptional regulator
FY145_RS07380	COG1914	H( )-stimulated, divalent metal cation uptake system
FY145_RS07390	COG1132	(ABC) transporter
FY145_RS07395	COG0628	permease
FY145_RS07430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY145_RS07440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY145_RS07450	COG0302	gtp cyclohydrolase
FY145_RS07455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY145_RS07460	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY145_RS07470	COG0516	GMP reductase activity
FY145_RS07470	COG0517	IMP dehydrogenase activity
FY145_RS07505	COG1760	l-serine dehydratase
FY145_RS07545	COG0583	DNA-binding transcription factor activity
FY145_RS07560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY145_RS07560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY145_RS07570	COG0347	Belongs to the P(II) protein family
FY145_RS07575	COG0174	glutamine synthetase
FY145_RS07605	COG0697	spore germination
FY145_RS07615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY145_RS07625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY145_RS07655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY145_RS07665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY145_RS07670	COG2186	Transcriptional regulator
FY145_RS07680	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY145_RS07685	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY145_RS07690	COG3845	ABC transporter
FY145_RS07695	COG1183	phosphatidylcholine synthase activity
FY145_RS07700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY145_RS07705	COG0679	Auxin Efflux Carrier
FY145_RS07710	COG0785	Cytochrome C biogenesis protein
FY145_RS07730	COG1278	Cold shock
FY145_RS07785	COG0577	efflux transmembrane transporter activity
FY145_RS07785	COG1136	(ABC) transporter
FY145_RS07790	COG0577	efflux transmembrane transporter activity
FY145_RS07790	COG1136	(ABC) transporter
FY145_RS07815	COG2151	metal-sulfur cluster biosynthetic enzyme
FY145_RS07820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY145_RS07825	COG0719	Fe-S assembly protein
FY145_RS07830	COG0396	ATPase activity
FY145_RS07835	COG0719	Fe-S assembly protein
FY145_RS07840	COG1104	cysteine desulfurase activity
FY145_RS07845	COG2945	thiolester hydrolase activity
FY145_RS07850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY145_RS07855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY145_RS07865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY145_RS07870	COG2833	Protein of unknown function (DUF455)
FY145_RS07875	COG0739	heme binding
FY145_RS07880	COG0513	Belongs to the DEAD box helicase family
FY145_RS07905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY145_RS07915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY145_RS07920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY145_RS07925	COG0047	phosphoribosylformylglycinamidine synthase activity
FY145_RS07940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY145_RS07945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY145_RS07965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY145_RS07970	COG2814	Major facilitator Superfamily
FY145_RS07975	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS07980	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS07985	COG0037	tRNA processing
FY145_RS07990	COG2066	Belongs to the glutaminase family
FY145_RS07995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY145_RS08000	COG0861	Integral membrane protein TerC family
FY145_RS08015	COG1280	lysine exporter protein (LysE YggA)
FY145_RS08025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY145_RS08030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY145_RS08040	COG0538	isocitrate dehydrogenase activity
FY145_RS08050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY145_RS08055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY145_RS08060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS08065	COG2313	pseudouridylate synthase activity
FY145_RS08075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS08080	COG4215	(ABC) transporter
FY145_RS08090	COG5425	PFAM Usg family protein
FY145_RS08100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS08105	COG1522	sequence-specific DNA binding
FY145_RS08110	COG1573	uracil-dna glycosylase
FY145_RS08120	COG2202	Pas domain
FY145_RS08120	COG2205	protein histidine kinase activity
FY145_RS08125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY145_RS08130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY145_RS08135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY145_RS08150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY145_RS08155	COG0842	Transport permease protein
FY145_RS08160	COG1131	(ABC) transporter
FY145_RS08165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY145_RS08165	COG0730	response to heat
FY145_RS08185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY145_RS08190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY145_RS08210	COG0129	dihydroxy-acid dehydratase activity
FY145_RS08215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY145_RS08220	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY145_RS08230	COG3739	integral membrane protein
FY145_RS08235	COG0203	ribosomal protein L17
FY145_RS08240	COG0202	RNA polymerase activity
FY145_RS08245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY145_RS08250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY145_RS08255	COG0563	adenylate kinase activity
FY145_RS08260	COG0201	protein transport
FY145_RS08265	COG0200	Binds to the 23S rRNA
FY145_RS08270	COG1841	ribosomal large subunit assembly
FY145_RS08275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY145_RS08280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY145_RS08285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY145_RS08290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY145_RS08295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY145_RS08300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY145_RS08305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY145_RS08310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY145_RS08315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY145_RS08320	COG0255	Belongs to the universal ribosomal protein uL29 family
FY145_RS08325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY145_RS08330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY145_RS08335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY145_RS08340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY145_RS08345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY145_RS08350	COG0089	rRNA binding
FY145_RS08355	COG0088	Forms part of the polypeptide exit tunnel
FY145_RS08360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY145_RS08365	COG0051	transcription antitermination factor activity, RNA binding
FY145_RS08370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY145_RS08375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY145_RS08380	COG0049	tRNA binding
FY145_RS08385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY145_RS08405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY145_RS08410	COG0085	RNA polymerase activity
FY145_RS08415	COG0222	ribosome binding
FY145_RS08420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY145_RS08425	COG0081	regulation of translation
FY145_RS08430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY145_RS08440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY145_RS08450	COG1086	Polysaccharide biosynthesis protein
FY145_RS08455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY145_RS08460	COG0861	Integral membrane protein TerC family
FY145_RS08465	COG3895	Periplasmic Protein
FY145_RS08485	COG1132	(ABC) transporter
FY145_RS08490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY145_RS08510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY145_RS08545	COG0784	Response regulator, receiver
FY145_RS08545	COG2198	Histidine kinase
FY145_RS08545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS08545	COG2205	protein histidine kinase activity
FY145_RS08550	COG0784	Response regulator, receiver
FY145_RS08555	COG2202	Pas domain
FY145_RS08555	COG3920	Histidine kinase
FY145_RS08560	COG0784	Response regulator, receiver
FY145_RS08565	COG4251	negative regulation of phosphorylation
FY145_RS08580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY145_RS08585	COG1607	acyl-coa hydrolase
FY145_RS08605	COG2910	NAD(P)H-binding
FY145_RS08610	COG1733	regulation of RNA biosynthetic process
FY145_RS08625	COG0556	nucleotide-excision repair
FY145_RS08635	COG2382	esterase
FY145_RS08655	COG0484	heat shock protein binding
FY145_RS08675	COG3706	GGDEF domain
FY145_RS08695	COG1840	ABC-type Fe3 transport system, periplasmic component
FY145_RS08700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY145_RS08715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY145_RS08725	COG2207	Transcriptional regulator
FY145_RS08730	COG1064	alcohol dehydrogenase
FY145_RS08735	COG1252	NADH dehydrogenase
FY145_RS08740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY145_RS08745	COG2197	response regulator
FY145_RS08750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY145_RS08785	COG0656	L-ascorbic acid biosynthetic process
FY145_RS08800	COG0440	acetolactate synthase activity
FY145_RS08805	COG0028	Belongs to the TPP enzyme family
FY145_RS08815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY145_RS08820	COG0560	Phosphoserine phosphatase
FY145_RS08820	COG3830	Belongs to the UPF0237 family
FY145_RS08840	COG0330	HflC and HflK could
FY145_RS08845	COG0330	HflC and HflK could
FY145_RS08855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY145_RS08890	COG0277	FAD linked oxidase domain protein
FY145_RS08895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY145_RS08935	COG1335	isochorismatase
FY145_RS08965	COG2264	protein methyltransferase activity
FY145_RS08970	COG1999	signal sequence binding
FY145_RS08980	COG0835	chemotaxis
FY145_RS08990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY145_RS08995	COG0583	DNA-binding transcription factor activity
FY145_RS09005	COG1247	-acetyltransferase
FY145_RS09015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY145_RS09020	COG0497	DNA recombination
FY145_RS09025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY145_RS09035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY145_RS09040	COG0849	cell division
FY145_RS09045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY145_RS09050	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY145_RS09055	COG0477	Major facilitator Superfamily
FY145_RS09060	COG5001	Diguanylate cyclase
FY145_RS09065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY145_RS09070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY145_RS09075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY145_RS09085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY145_RS09090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY145_RS09100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY145_RS09115	COG0275	rRNA processing
FY145_RS09120	COG2001	Belongs to the MraZ family
FY145_RS09145	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY145_RS09175	COG4106	trans-aconitate 2-methyltransferase activity
FY145_RS09195	COG2226	methyltransferase
FY145_RS09205	COG2267	carboxylic ester hydrolase activity
FY145_RS09210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY145_RS09225	COG0251	oxidation-reduction process
FY145_RS09240	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS09245	COG2814	Major facilitator Superfamily
FY145_RS09275	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS09280	COG0174	glutamine synthetase
FY145_RS09285	COG0531	amino acid
FY145_RS09295	COG1737	Transcriptional regulator
FY145_RS09300	COG2182	Extracellular solute-binding protein
FY145_RS09315	COG3842	ATPase activity
FY145_RS09375	COG2968	Membrane
FY145_RS09385	COG0432	Pfam Uncharacterised protein family UPF0047
FY145_RS09400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY145_RS09405	COG0358	DNA primase activity
FY145_RS09425	COG0505	Belongs to the CarA family
FY145_RS09430	COG0534	Mate efflux family protein
FY145_RS09445	COG2321	neutral zinc metallopeptidase
FY145_RS09460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY145_RS09470	COG3706	GGDEF domain
FY145_RS09485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY145_RS09495	COG1522	sequence-specific DNA binding
FY145_RS09500	COG0492	ferredoxin-NADP+ reductase activity
FY145_RS09505	COG0583	DNA-binding transcription factor activity
FY145_RS09515	COG1902	pentaerythritol trinitrate reductase activity
FY145_RS09540	COG0387	Pfam Sodium calcium exchanger
FY145_RS09545	COG0436	Aminotransferase
FY145_RS09550	COG2199	diguanylate cyclase activity
FY145_RS09550	COG2200	EAL domain
FY145_RS09565	COG1278	Cold shock
FY145_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY145_RS09580	COG1846	Transcriptional regulator
FY145_RS09585	COG0745	RESPONSE REGULATOR receiver
FY145_RS09595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY145_RS09615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY145_RS09625	COG1496	oxidoreductase activity
FY145_RS09640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY145_RS09650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FY145_RS09665	COG0840	transmembrane signaling receptor activity
FY145_RS09670	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS09675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY145_RS09680	COG3300	MHYT domain
FY145_RS09680	COG5001	Diguanylate cyclase
FY145_RS09685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY145_RS09690	COG5001	Diguanylate cyclase
FY145_RS09700	COG0193	aminoacyl-tRNA hydrolase activity
FY145_RS09710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY145_RS09735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY145_RS09745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY145_RS09745	COG2857	Cytochrome c1
FY145_RS09765	COG1132	(ABC) transporter
FY145_RS09775	COG1132	(ABC) transporter
FY145_RS09785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY145_RS09800	COG0408	coproporphyrinogen oxidase activity
FY145_RS09815	COG0617	tRNA 3'-terminal CCA addition
FY145_RS09830	COG0714	Associated with various cellular activities
FY145_RS09850	COG0454	-acetyltransferase
FY145_RS09865	COG0477	Major facilitator Superfamily
FY145_RS09875	COG0435	Glutathione S-transferase
FY145_RS09880	COG0494	nUDIX hydrolase
FY145_RS09890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY145_RS09895	COG3135	benzoate transporter
FY145_RS09920	COG0740	serine-type endopeptidase activity
FY145_RS09935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY145_RS09940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY145_RS09965	COG4175	Glycine betaine
FY145_RS09985	COG1435	thymidine kinase activity
FY145_RS10010	COG1629	transport
FY145_RS10010	COG4771	TonB-dependent receptor
FY145_RS10020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY145_RS10020	COG0512	Glutamine amidotransferase of anthranilate synthase
FY145_RS10035	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY145_RS10045	COG0366	Alpha amylase catalytic
FY145_RS10050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS10070	COG1160	GTP binding
FY145_RS10090	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY145_RS10100	COG0024	Methionine aminopeptidase
FY145_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS10130	COG0583	DNA-binding transcription factor activity
FY145_RS10145	COG0402	S-adenosylhomocysteine deaminase activity
FY145_RS10155	COG1304	FMN binding
FY145_RS10165	COG1309	transcriptional regulator
FY145_RS10170	COG1686	Belongs to the peptidase S11 family
FY145_RS10180	COG2351	hydroxyisourate hydrolase activity
FY145_RS10185	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY145_RS10210	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY145_RS10220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS10220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY145_RS10230	COG0513	Belongs to the DEAD box helicase family
FY145_RS10240	COG2259	Doxx family
FY145_RS10245	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS10255	COG2308	Evidence 4 Homologs of previously reported genes of
FY145_RS10265	COG1305	Transglutaminase-like
FY145_RS10290	COG4214	carbohydrate transport
FY145_RS10300	COG4213	ABC transporter substrate-binding protein
FY145_RS10355	COG2948	multi-organism process
FY145_RS10365	COG3701	Conjugal transfer protein
FY145_RS10370	COG3846	protein secretion by the type IV secretion system
FY145_RS10385	COG3451	type IV secretory pathway VirB4
FY145_RS10400	COG4962	Type ii secretion system protein e
FY145_RS10425	COG0583	DNA-binding transcription factor activity
FY145_RS10435	COG1566	PFAM secretion protein HlyD family protein
FY145_RS10450	COG2207	Transcriptional regulator
FY145_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS10465	COG0583	DNA-binding transcription factor activity
FY145_RS10475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY145_RS10490	COG0583	DNA-binding transcription factor activity
FY145_RS10525	COG1192	Involved in chromosome partitioning
FY145_RS10565	COG2814	Major facilitator Superfamily
FY145_RS10575	COG5489	Protein of unknown function (DUF736)
FY145_RS10590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY145_RS10620	COG1204	response to ionizing radiation
FY145_RS10635	COG0514	ATP-dependent DNA helicase (RecQ)
FY145_RS10685	COG0583	DNA-binding transcription factor activity
FY145_RS10690	COG1902	pentaerythritol trinitrate reductase activity
FY145_RS10695	COG0583	DNA-binding transcription factor activity
FY145_RS10710	COG1335	isochorismatase
FY145_RS10715	COG0583	DNA-binding transcription factor activity
FY145_RS10720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY145_RS10730	COG4584	PFAM Integrase catalytic
FY145_RS10745	COG0840	transmembrane signaling receptor activity
FY145_RS10760	COG1410	methionine synthase
FY145_RS10760	COG0646	methionine synthase
FY145_RS10775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS10805	COG1215	transferase activity, transferring glycosyl groups
FY145_RS10835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY145_RS10850	COG2346	COG2346, Truncated hemoglobins
FY145_RS10870	COG1309	transcriptional regulator
FY145_RS10885	COG0494	nUDIX hydrolase
FY145_RS10895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS10900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS10930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY145_RS10935	COG0830	nickel cation binding
FY145_RS10940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY145_RS10955	COG0804	urea catabolic process
FY145_RS10960	COG1442	glycosyl transferase family 8
FY145_RS10965	COG3755	Protein conserved in bacteria
FY145_RS10975	COG0832	Belongs to the urease beta subunit family
FY145_RS10980	COG3813	Protein conserved in bacteria
FY145_RS10985	COG0831	urea catabolic process
FY145_RS10990	COG0829	nickel cation binding
FY145_RS11020	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY145_RS11040	COG0174	glutamine synthetase
FY145_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS11050	COG2198	Histidine kinase
FY145_RS11050	COG0784	Response regulator, receiver
FY145_RS11050	COG5002	protein histidine kinase activity
FY145_RS11065	COG0726	polysaccharide deacetylase
FY145_RS11100	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY145_RS11175	COG0564	pseudouridine synthase activity
FY145_RS11185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY145_RS11195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY145_RS11220	COG0346	lactoylglutathione lyase activity
FY145_RS11230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY145_RS11240	COG2832	Protein of unknown function (DUF454)
FY145_RS11245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY145_RS11250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS11255	COG4558	Periplasmic binding protein
FY145_RS11265	COG3721	Heme iron utilization protein
FY145_RS11280	COG3655	Transcriptional regulator
FY145_RS11305	COG2205	protein histidine kinase activity
FY145_RS11345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS11350	COG4605	iron ion homeostasis
FY145_RS11355	COG4604	ABC transporter, ATP-binding protein
FY145_RS11360	COG0783	Belongs to the Dps family
FY145_RS11375	COG0840	transmembrane signaling receptor activity
FY145_RS11375	COG2972	Histidine kinase
FY145_RS11380	COG0656	L-ascorbic acid biosynthetic process
FY145_RS11385	COG2814	Major facilitator Superfamily
FY145_RS11395	COG0583	DNA-binding transcription factor activity
FY145_RS11400	COG0657	acetylesterase activity
FY145_RS11405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS11425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY145_RS11430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY145_RS11435	COG0288	reversible hydration of carbon dioxide
FY145_RS11445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY145_RS11465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY145_RS11470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY145_RS11475	COG0778	Nitroreductase
FY145_RS11480	COG2267	carboxylic ester hydrolase activity
FY145_RS11485	COG0251	oxidation-reduction process
FY145_RS11490	COG1335	isochorismatase
FY145_RS11495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS11505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS11520	COG1175	transmembrane transport
FY145_RS11525	COG0395	ABC-type sugar transport system, permease component
FY145_RS11530	COG3842	ATPase activity
FY145_RS11535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS11545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY145_RS11560	COG4608	Belongs to the ABC transporter superfamily
FY145_RS11565	COG0444	Belongs to the ABC transporter superfamily
FY145_RS11570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS11575	COG0601	transmembrane transport
FY145_RS11630	COG2159	amidohydrolase
FY145_RS11635	COG1960	acyl-CoA dehydrogenase activity
FY145_RS11665	COG0745	RESPONSE REGULATOR receiver
FY145_RS11675	COG1902	pentaerythritol trinitrate reductase activity
FY145_RS11675	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY145_RS11680	COG3842	ATPase activity
FY145_RS11690	COG1840	ABC-type Fe3 transport system, periplasmic component
FY145_RS11695	COG1840	ABC-type Fe3 transport system, periplasmic component
FY145_RS11700	COG0745	RESPONSE REGULATOR receiver
FY145_RS11710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY145_RS11715	COG0583	DNA-binding transcription factor activity
FY145_RS11720	COG1278	Cold shock
FY145_RS11760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY145_RS11765	COG1309	transcriptional regulator
FY145_RS11770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS11775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY145_RS11785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY145_RS11790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY145_RS11810	COG0583	DNA-binding transcription factor activity
FY145_RS11815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS11820	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY145_RS11825	COG4149	molybdate abc transporter
FY145_RS11830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY145_RS11845	COG2022	thiamine diphosphate biosynthetic process
FY145_RS11860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY145_RS11865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY145_RS11875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY145_RS11895	COG1132	(ABC) transporter
FY145_RS11900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY145_RS11945	COG4166	transmembrane transport
FY145_RS11950	COG0601	transmembrane transport
FY145_RS11955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS11970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY145_RS11975	COG3142	Participates in the control of copper homeostasis
FY145_RS11980	COG2814	Major facilitator Superfamily
FY145_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS12000	COG1737	Transcriptional regulator
FY145_RS12010	COG3842	ATPase activity
FY145_RS12020	COG0395	ABC-type sugar transport system, permease component
FY145_RS12040	COG2188	Transcriptional regulator
FY145_RS12045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY145_RS12050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY145_RS12055	COG1940	carbohydrate kinase activity
FY145_RS12065	COG0671	phosphoesterase, PA-phosphatase related
FY145_RS12070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY145_RS12075	COG0156	8-amino-7-oxononanoate synthase activity
FY145_RS12085	COG0729	surface antigen
FY145_RS12095	COG0835	chemotaxis
FY145_RS12105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY145_RS12110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY145_RS12115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY145_RS12120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY145_RS12125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY145_RS12130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY145_RS12145	COG4974	Belongs to the 'phage' integrase family
FY145_RS12170	COG1280	lysine exporter protein (LysE YggA)
FY145_RS12180	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY145_RS12185	COG0567	Dehydrogenase, E1 component
FY145_RS12190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY145_RS12195	COG0045	succinate-CoA ligase (ADP-forming) activity
FY145_RS12200	COG0039	L-malate dehydrogenase activity
FY145_RS12205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY145_RS12255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY145_RS12260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY145_RS12265	COG0181	hydroxymethylbilane synthase activity
FY145_RS12305	COG1872	DUF167
FY145_RS12310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY145_RS12320	COG1217	gtp-binding protein TYPA
FY145_RS12325	COG0339	signal peptide processing
FY145_RS12330	COG1846	Transcriptional regulator
FY145_RS12340	COG0137	argininosuccinate synthase activity
FY145_RS12350	COG1280	lysine exporter protein (LysE YggA)
FY145_RS12355	COG1122	ATPase activity
FY145_RS12360	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY145_RS12370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY145_RS12385	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY145_RS12390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY145_RS12395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY145_RS12405	COG4181	ATPase activity
FY145_RS12415	COG0670	Belongs to the BI1 family
FY145_RS12430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY145_RS12435	COG4133	protoheme IX ABC transporter activity
FY145_RS12440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY145_RS12445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY145_RS12470	COG2917	probably involved in intracellular septation
FY145_RS12475	COG0552	protein localization to endoplasmic reticulum
FY145_RS12480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY145_RS12485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY145_RS12500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY145_RS12505	COG1605	Chorismate mutase
FY145_RS12505	COG0287	Prephenate dehydrogenase
FY145_RS12510	COG0228	four-way junction DNA binding
FY145_RS12515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY145_RS12520	COG0336	Belongs to the RNA methyltransferase TrmD family
FY145_RS12530	COG0335	large ribosomal subunit rRNA binding
FY145_RS12535	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY145_RS12540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS12555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY145_RS12575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY145_RS12595	COG0488	(ABC) transporter
FY145_RS12605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY145_RS12615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY145_RS12620	COG0142	geranyltranstransferase activity
FY145_RS12625	COG2885	chlorophyll binding
FY145_RS12630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY145_RS12635	COG2223	nitrite transmembrane transporter activity
FY145_RS12640	COG1349	DNA-binding transcription factor activity
FY145_RS12645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY145_RS12650	COG2197	response regulator
FY145_RS12655	COG1132	(ABC) transporter
FY145_RS12665	COG3459	Glycosyltransferase 36 associated
FY145_RS12670	COG1473	amidohydrolase
FY145_RS12680	COG0579	oxidoreductase
FY145_RS12690	COG0129	dihydroxy-acid dehydratase activity
FY145_RS12695	COG2084	Dehydrogenase
FY145_RS12700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS12705	COG0277	FAD linked oxidase domain protein
FY145_RS12710	COG2186	Transcriptional regulator
FY145_RS12720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY145_RS12725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY145_RS12730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY145_RS12735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY145_RS12745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY145_RS12750	COG0495	leucyl-tRNA aminoacylation
FY145_RS12765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY145_RS12770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY145_RS12785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY145_RS12790	COG1946	Acyl-CoA thioesterase
FY145_RS12795	COG0347	Belongs to the P(II) protein family
FY145_RS12800	COG0004	ammonium transporteR
FY145_RS12805	COG1674	ftsk spoiiie
FY145_RS12810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY145_RS12825	COG0745	RESPONSE REGULATOR receiver
FY145_RS12835	COG1329	Transcriptional regulator
FY145_RS12845	COG2270	Major facilitator Superfamily
FY145_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS12875	COG0494	nUDIX hydrolase
FY145_RS12880	COG2861	carbohydrate metabolic process
FY145_RS12885	COG0793	Belongs to the peptidase S41A family
FY145_RS12895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY145_RS12900	COG0799	negative regulation of ribosome biogenesis
FY145_RS12905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY145_RS12910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY145_RS12915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY145_RS12920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY145_RS12935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY145_RS12940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY145_RS12965	COG0066	3-isopropylmalate dehydratase activity
FY145_RS12970	COG0473	3-isopropylmalate dehydrogenase activity
FY145_RS12975	COG1858	cytochrome C peroxidase
FY145_RS12980	COG1797	cobyrinic acid a,c-diamide synthase activity
FY145_RS12990	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY145_RS13055	COG1492	cobalamin metabolic process
FY145_RS13070	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS13075	COG3254	rhamnose metabolic process
FY145_RS13080	COG0246	Mannitol dehydrogenase
FY145_RS13085	COG1063	alcohol dehydrogenase
FY145_RS13110	COG1129	ABC transporter
FY145_RS13115	COG2186	Transcriptional regulator
FY145_RS13120	COG2721	sulfolactate sulfo-lyase activity
FY145_RS13125	COG0138	bifunctional purine biosynthesis protein purh
FY145_RS13135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY145_RS13135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY145_RS13140	COG0501	Belongs to the peptidase M48B family
FY145_RS13160	COG0357	Ribosomal RNA small subunit methyltransferase G
FY145_RS13165	COG0445	tRNA wobble uridine modification
FY145_RS13170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY145_RS13175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY145_RS13180	COG1981	membrane
FY145_RS13185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY145_RS13190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY145_RS13195	COG0424	maF-like protein
FY145_RS13200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY145_RS13205	COG0237	dephospho-CoA kinase activity
FY145_RS13215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY145_RS13220	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY145_RS13230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY145_RS13255	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY145_RS13270	COG0135	phosphoribosylanthranilate isomerase activity
FY145_RS13275	COG0133	tryptophan synthase activity
FY145_RS13280	COG0159	tryptophan synthase activity
FY145_RS13285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY145_RS13300	COG1074	ATP-dependent DNA helicase activity
FY145_RS13310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY145_RS13315	COG0802	atpase or kinase
FY145_RS13320	COG2205	protein histidine kinase activity
FY145_RS13325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY145_RS13330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY145_RS13335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY145_RS13335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY145_RS13340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY145_RS13345	COG0642	Histidine kinase
FY145_RS13350	COG0745	RESPONSE REGULATOR receiver
FY145_RS13355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY145_RS13365	COG1652	LysM domain
FY145_RS13370	COG1072	(Pantothenic acid kinase))
FY145_RS13375	COG0140	phosphoribosyl-ATP diphosphatase activity
FY145_RS13380	COG0107	imidazoleglycerol-phosphate synthase activity
FY145_RS13385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY145_RS13390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY145_RS13400	COG0131	Imidazoleglycerol-phosphate dehydratase
FY145_RS13405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY145_RS13410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY145_RS13420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY145_RS13435	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY145_RS13445	COG1643	Atp-dependent helicase
FY145_RS13490	COG1940	carbohydrate kinase activity
FY145_RS13510	COG1072	(Pantothenic acid kinase))
FY145_RS13520	COG1780	Probably involved in ribonucleotide reductase function
FY145_RS13540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY145_RS13570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS13580	COG2813	Specifically methylates the guanine in position
FY145_RS13585	COG1185	polyribonucleotide nucleotidyltransferase activity
FY145_RS13590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY145_RS13595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY145_RS13600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY145_RS13605	COG3064	Membrane
FY145_RS13605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY145_RS13620	COG0779	Required for maturation of 30S ribosomal subunits
FY145_RS13625	COG2814	Major facilitator Superfamily
FY145_RS13635	COG2951	lytic endotransglycosylase activity
FY145_RS13640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY145_RS13650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY145_RS13655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY145_RS13670	COG2816	NAD+ diphosphatase activity
FY145_RS13675	COG1605	Chorismate mutase
FY145_RS13675	COG0077	Prephenate dehydratase
FY145_RS13680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY145_RS13685	COG3474	cytochrome
FY145_RS13695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY145_RS13700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY145_RS13705	COG1278	Cold shock
FY145_RS13710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY145_RS13720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY145_RS13720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY145_RS13725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY145_RS13755	COG2900	Belongs to the SlyX family
FY145_RS13765	COG0484	heat shock protein binding
FY145_RS13770	COG0443	Heat shock 70 kDa protein
FY145_RS13785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY145_RS13790	COG1744	ABC transporter substrate-binding protein PnrA-like
FY145_RS13795	COG3845	ABC transporter
FY145_RS13800	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY145_RS13805	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY145_RS13810	COG0295	cytidine deaminase activity
FY145_RS13815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FY145_RS13820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY145_RS13825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY145_RS13835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY145_RS13840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY145_RS13845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY145_RS13855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY145_RS13860	COG1845	cytochrome c oxidase, subunit III
FY145_RS13865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY145_RS13870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY145_RS13875	COG0477	Major facilitator Superfamily
FY145_RS13880	COG0067	glutamate synthase
FY145_RS13880	COG0069	glutamate synthase activity
FY145_RS13880	COG0070	glutamate synthase
FY145_RS13885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY145_RS13900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY145_RS13910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY145_RS13940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS13960	COG0848	biopolymer transport protein
FY145_RS13970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY145_RS13985	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY145_RS13990	COG3454	Phosphonate metabolism
FY145_RS13995	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY145_RS14000	COG3639	organic phosphonate transmembrane transporter activity
FY145_RS14005	COG3639	organic phosphonate transmembrane transporter activity
FY145_RS14015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY145_RS14025	COG4778	phosphonate C-P lyase system protein PhnL
FY145_RS14030	COG4107	phosphonate C-P lyase system protein PhnK
FY145_RS14035	COG3627	carbon phosphorus lyase activity
FY145_RS14040	COG3626	phosphonate metabolism
FY145_RS14045	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY145_RS14050	COG3624	Phosphonate C-P lyase system protein PhnG
FY145_RS14055	COG2188	Transcriptional regulator
FY145_RS14060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY145_RS14065	COG0837	glucose binding
FY145_RS14070	COG1803	Methylglyoxal synthase
FY145_RS14075	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY145_RS14080	COG4166	transmembrane transport
FY145_RS14085	COG4174	ABC transporter (Permease)
FY145_RS14090	COG4239	(ABC) transporter, permease
FY145_RS14095	COG4172	Belongs to the ABC transporter superfamily
FY145_RS14100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS14105	COG0174	glutamine synthetase
FY145_RS14110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS14115	COG3265	gluconokinase activity
FY145_RS14120	COG1174	glycine betaine transport
FY145_RS14125	COG1125	glycine betaine transport
FY145_RS14130	COG1174	glycine betaine transport
FY145_RS14135	COG1732	Glycine betaine
FY145_RS14145	COG1959	2 iron, 2 sulfur cluster binding
FY145_RS14150	COG1840	ABC-type Fe3 transport system, periplasmic component
FY145_RS14160	COG4269	membrane
FY145_RS14175	COG0697	spore germination
FY145_RS14190	COG0791	NLP P60 protein
FY145_RS14200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY145_RS14205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY145_RS14240	COG4964	Belongs to the GSP D family
FY145_RS14285	COG3422	double-strand break repair
FY145_RS14290	COG3757	hydrolase, family 25
FY145_RS14295	COG0697	spore germination
FY145_RS14300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY145_RS14315	COG0492	ferredoxin-NADP+ reductase activity
FY145_RS14330	COG0481	GTPase activity
FY145_RS14335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY145_RS14350	COG1396	sequence-specific DNA binding
FY145_RS14365	COG2169	Transcriptional regulator
FY145_RS14365	COG1917	Cupin 2, conserved barrel domain protein
FY145_RS14370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY145_RS14395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY145_RS14400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY145_RS14405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY145_RS14415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY145_RS14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY145_RS14420	COG0072	phenylalanine-tRNA ligase activity
FY145_RS14425	COG0667	Aldo Keto reductase
FY145_RS14445	COG4977	sequence-specific DNA binding
FY145_RS14470	COG1570	exodeoxyribonuclease VII activity
FY145_RS14475	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS14485	COG1846	Transcriptional regulator
FY145_RS14495	COG2309	aminopeptidase activity
FY145_RS14505	COG1393	Belongs to the ArsC family
FY145_RS14525	COG1309	transcriptional regulator
FY145_RS14535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY145_RS14535	COG0519	Catalyzes the synthesis of GMP from XMP
FY145_RS14550	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY145_RS14580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY145_RS14590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY145_RS14600	COG1968	undecaprenyl-diphosphatase activity
FY145_RS14615	COG0284	orotidine-5'-phosphate decarboxylase activity
FY145_RS14625	COG3963	phosphatidate phosphatase activity
FY145_RS14635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY145_RS14640	COG0792	nuclease activity
FY145_RS14655	COG1175	transmembrane transport
FY145_RS14660	COG0395	ABC-type sugar transport system, permease component
FY145_RS14665	COG3842	ATPase activity
FY145_RS14675	COG0189	ligase activity
FY145_RS14685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY145_RS14690	COG1280	lysine exporter protein (LysE YggA)
FY145_RS14695	COG0756	dUTP diphosphatase activity
FY145_RS14700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY145_RS14705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY145_RS14720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY145_RS14725	COG2226	methyltransferase
FY145_RS14730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY145_RS14735	COG1024	Enoyl-CoA hydratase
FY145_RS14740	COG0268	Binds directly to 16S ribosomal RNA
FY145_RS14750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY145_RS14780	COG1278	Cold shock
FY145_RS14815	COG0411	ABC transporter
FY145_RS14820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY145_RS14825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY145_RS14830	COG1454	alcohol dehydrogenase
FY145_RS14835	COG0747	negative chemotaxis
FY145_RS14840	COG0601	transmembrane transport
FY145_RS14850	COG4608	Belongs to the ABC transporter superfamily
FY145_RS14855	COG1349	DNA-binding transcription factor activity
FY145_RS14860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY145_RS14885	COG4302	ethanolamine ammonia-lyase activity
FY145_RS14890	COG0025	NhaP-type Na H and K H
FY145_RS14895	COG4106	trans-aconitate 2-methyltransferase activity
FY145_RS14905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS14910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS14915	COG0601	transmembrane transport
FY145_RS14940	COG4172	Belongs to the ABC transporter superfamily
FY145_RS14975	COG0596	Alpha beta hydrolase
FY145_RS14990	COG1764	response to oxidative stress
FY145_RS15000	COG0596	Alpha beta hydrolase
FY145_RS15020	COG0783	Belongs to the Dps family
FY145_RS15025	COG0243	molybdopterin cofactor binding
FY145_RS15035	COG4566	intracellular signal transduction
FY145_RS15040	COG4566	intracellular signal transduction
FY145_RS15070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY145_RS15080	COG1414	Transcriptional regulator
FY145_RS15095	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS15115	COG1522	sequence-specific DNA binding
FY145_RS15135	COG0628	permease
FY145_RS15145	COG2235	arginine
FY145_RS15180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY145_RS15190	COG0702	epimerase
FY145_RS15195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY145_RS15200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS15205	COG0745	RESPONSE REGULATOR receiver
FY145_RS15210	COG5002	protein histidine kinase activity
FY145_RS15225	COG2233	PERMEase
FY145_RS15285	COG0395	ABC-type sugar transport system, permease component
FY145_RS15290	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS15300	COG3842	ATPase activity
FY145_RS15335	COG1653	transport
FY145_RS15345	COG0395	ABC-type sugar transport system, permease component
FY145_RS15350	COG3842	ATPase activity
FY145_RS15365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS15370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS15375	COG1116	anion transmembrane transporter activity
FY145_RS15380	COG0395	ABC-type sugar transport system, permease component
FY145_RS15385	COG1175	transmembrane transport
FY145_RS15415	COG1609	Transcriptional regulator
FY145_RS15430	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS15435	COG3842	ATPase activity
FY145_RS15440	COG0395	ABC-type sugar transport system, permease component
FY145_RS15445	COG1175	transmembrane transport
FY145_RS15450	COG1653	transport
FY145_RS15455	COG1309	transcriptional regulator
FY145_RS15460	COG0673	inositol 2-dehydrogenase activity
FY145_RS15475	COG0673	inositol 2-dehydrogenase activity
FY145_RS15485	COG1278	Cold shock
FY145_RS15495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY145_RS15520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY145_RS15525	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY145_RS15540	COG3842	ATPase activity
FY145_RS15545	COG0395	ABC-type sugar transport system, permease component
FY145_RS15550	COG1175	transmembrane transport
FY145_RS15560	COG3618	amidohydrolase
FY145_RS15565	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS15570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS15580	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY145_RS15585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS15590	COG2186	Transcriptional regulator
FY145_RS15605	COG0667	Aldo Keto reductase
FY145_RS15635	COG4977	sequence-specific DNA binding
FY145_RS15640	COG2223	nitrite transmembrane transporter activity
FY145_RS15645	COG1609	Transcriptional regulator
FY145_RS15650	COG1063	alcohol dehydrogenase
FY145_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS15665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS15670	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY145_RS15675	COG1175	transmembrane transport
FY145_RS15680	COG0395	ABC-type sugar transport system, permease component
FY145_RS15695	COG0395	ABC-type sugar transport system, permease component
FY145_RS15705	COG2182	Extracellular solute-binding protein
FY145_RS15710	COG0626	cystathionine gamma-synthase activity
FY145_RS15725	COG0454	-acetyltransferase
FY145_RS15730	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY145_RS15740	COG1121	(ABC) transporter
FY145_RS15745	COG0523	cobalamin synthesis protein
FY145_RS15760	COG0523	cobalamin synthesis protein
FY145_RS15765	COG1653	transport
FY145_RS15770	COG1175	transmembrane transport
FY145_RS15775	COG0395	ABC-type sugar transport system, permease component
FY145_RS15780	COG3842	ATPase activity
FY145_RS15790	COG3047	cAMP biosynthetic process
FY145_RS15815	COG0583	DNA-binding transcription factor activity
FY145_RS15820	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS15825	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS15830	COG1129	ABC transporter
FY145_RS15840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY145_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS15855	COG3257	ureidoglycine aminohydrolase activity
FY145_RS15865	COG5001	Diguanylate cyclase
FY145_RS15870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY145_RS15880	COG0747	negative chemotaxis
FY145_RS15885	COG0601	transmembrane transport
FY145_RS15890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS15900	COG4608	Belongs to the ABC transporter superfamily
FY145_RS15905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY145_RS15920	COG0346	lactoylglutathione lyase activity
FY145_RS15930	COG0129	dihydroxy-acid dehydratase activity
FY145_RS15935	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS15940	COG1129	ABC transporter
FY145_RS15945	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS15950	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS15955	COG2186	Transcriptional regulator
FY145_RS15970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY145_RS15975	COG0587	DNA-directed DNA polymerase activity
FY145_RS16005	COG0673	inositol 2-dehydrogenase activity
FY145_RS16015	COG3842	ATPase activity
FY145_RS16020	COG0395	ABC-type sugar transport system, permease component
FY145_RS16025	COG1175	transmembrane transport
FY145_RS16030	COG1653	transport
FY145_RS16040	COG0673	inositol 2-dehydrogenase activity
FY145_RS16055	COG5001	Diguanylate cyclase
FY145_RS16065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS16070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY145_RS16075	COG2894	cell division
FY145_RS16080	COG0850	regulation of cytokinetic process
FY145_RS16085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY145_RS16090	COG2186	Transcriptional regulator
FY145_RS16095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY145_RS16105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY145_RS16110	COG1063	alcohol dehydrogenase
FY145_RS16115	COG1312	Catalyzes the dehydration of D-mannonate
FY145_RS16135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY145_RS16140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY145_RS16140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY145_RS16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS16160	COG0625	glutathione transferase activity
FY145_RS16165	COG4172	Belongs to the ABC transporter superfamily
FY145_RS16170	COG1921	L-seryl-tRNASec selenium transferase activity
FY145_RS16185	COG3964	amidohydrolase
FY145_RS16195	COG0601	transmembrane transport
FY145_RS16200	COG0747	negative chemotaxis
FY145_RS16205	COG0438	transferase activity, transferring glycosyl groups
FY145_RS16240	COG4989	oxidoreductase activity
FY145_RS16250	COG2188	Transcriptional regulator
FY145_RS16255	COG3842	ATPase activity
FY145_RS16260	COG1653	transport
FY145_RS16265	COG1175	transmembrane transport
FY145_RS16270	COG0395	ABC-type sugar transport system, permease component
FY145_RS16275	COG1501	Belongs to the glycosyl hydrolase 31 family
FY145_RS16285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS16290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS16295	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY145_RS16300	COG0352	thiamine-phosphate diphosphorylase activity
FY145_RS16305	COG0351	phosphomethylpyrimidine kinase
FY145_RS16310	COG1522	sequence-specific DNA binding
FY145_RS16315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY145_RS16320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS16335	COG2204	response regulator
FY145_RS16340	COG4191	Histidine kinase
FY145_RS16345	COG1301	dicarboxylic acid transport
FY145_RS16350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY145_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS16365	COG1473	amidohydrolase
FY145_RS16385	COG1215	transferase activity, transferring glycosyl groups
FY145_RS16395	COG2942	2-epimerase
FY145_RS16420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS16430	COG2197	response regulator
FY145_RS16460	COG3307	-O-antigen
FY145_RS16465	COG1596	polysaccharide export
FY145_RS16470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY145_RS16480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY145_RS16485	COG0840	transmembrane signaling receptor activity
FY145_RS16490	COG1376	ErfK ybiS ycfS ynhG family protein
FY145_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS16510	COG2094	Belongs to the DNA glycosylase MPG family
FY145_RS16525	COG1609	Transcriptional regulator
FY145_RS16530	COG1653	transport
FY145_RS16545	COG3842	ATPase activity
FY145_RS16555	COG0673	inositol 2-dehydrogenase activity
FY145_RS16560	COG0602	queuosine metabolic process
FY145_RS16565	COG0720	synthase
FY145_RS16570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY145_RS16580	COG0673	inositol 2-dehydrogenase activity
FY145_RS16595	COG0395	ABC-type sugar transport system, permease component
FY145_RS16600	COG1175	transmembrane transport
FY145_RS16625	COG0583	DNA-binding transcription factor activity
FY145_RS16630	COG0281	malic enzyme
FY145_RS16630	COG0280	phosphate acetyltransferase
FY145_RS16645	COG0765	amino acid transport
FY145_RS16650	COG1126	abc transporter atp-binding protein
FY145_RS16655	COG2079	MmgE PrpD family protein
FY145_RS16660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS16670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS16685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY145_RS16695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY145_RS16700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY145_RS16705	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS16710	COG1129	ABC transporter
FY145_RS16725	COG1473	amidohydrolase
FY145_RS16730	COG0747	negative chemotaxis
FY145_RS16745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS16750	COG0601	transmembrane transport
FY145_RS16755	COG0583	DNA-binding transcription factor activity
FY145_RS16760	COG1446	asparaginase
FY145_RS16775	COG0747	negative chemotaxis
FY145_RS16795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS16800	COG0601	transmembrane transport
FY145_RS16805	COG2197	response regulator
FY145_RS16810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY145_RS16815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS16825	COG3842	ATPase activity
FY145_RS16830	COG0395	ABC-type sugar transport system, permease component
FY145_RS16835	COG1175	transmembrane transport
FY145_RS16845	COG0673	inositol 2-dehydrogenase activity
FY145_RS16850	COG0673	inositol 2-dehydrogenase activity
FY145_RS16870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS16875	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY145_RS16895	COG1595	DNA-templated transcription, initiation
FY145_RS16900	COG1120	ATPase activity
FY145_RS16905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS16920	COG2226	methyltransferase
FY145_RS16930	COG1120	ATPase activity
FY145_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS16980	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS16985	COG0473	3-isopropylmalate dehydrogenase activity
FY145_RS16990	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS16995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS17030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS17035	COG4172	Belongs to the ABC transporter superfamily
FY145_RS17040	COG1522	sequence-specific DNA binding
FY145_RS17050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS17065	COG0583	DNA-binding transcription factor activity
FY145_RS17075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS17080	COG1126	abc transporter atp-binding protein
FY145_RS17095	COG1473	amidohydrolase
FY145_RS17100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17110	COG1959	2 iron, 2 sulfur cluster binding
FY145_RS17120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY145_RS17125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17155	COG1960	acyl-CoA dehydrogenase activity
FY145_RS17165	COG0747	negative chemotaxis
FY145_RS17180	COG0444	Belongs to the ABC transporter superfamily
FY145_RS17190	COG0667	Aldo Keto reductase
FY145_RS17200	COG0583	DNA-binding transcription factor activity
FY145_RS17205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17210	COG4166	transmembrane transport
FY145_RS17225	COG0747	negative chemotaxis
FY145_RS17230	COG1473	amidohydrolase
FY145_RS17235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS17265	COG1733	regulation of RNA biosynthetic process
FY145_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS17405	COG4373	Mu-like prophage FluMu protein gp28
FY145_RS17410	COG4383	Mu-like prophage protein gp29
FY145_RS17415	COG2369	cell adhesion
FY145_RS17550	COG4608	Belongs to the ABC transporter superfamily
FY145_RS17555	COG0444	Belongs to the ABC transporter superfamily
FY145_RS17565	COG0601	transmembrane transport
FY145_RS17575	COG2186	Transcriptional regulator
FY145_RS17590	COG0300	oxidoreductase activity
FY145_RS17600	COG3453	Protein conserved in bacteria
FY145_RS17600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY145_RS17605	COG0640	Transcriptional regulator
FY145_RS17615	COG2391	methyltransferase activity
FY145_RS17620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY145_RS17630	COG0022	dehydrogenase e1 component
FY145_RS17640	COG1960	acyl-CoA dehydrogenase activity
FY145_RS17645	COG0183	Belongs to the thiolase family
FY145_RS17655	COG1960	acyl-CoA dehydrogenase activity
FY145_RS17660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY145_RS17680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY145_RS17685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY145_RS17690	COG4952	isomerase
FY145_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS17695	COG3347	Dehydrogenase
FY145_RS17700	COG1349	DNA-binding transcription factor activity
FY145_RS17710	COG1129	ABC transporter
FY145_RS17715	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS17720	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS17725	COG3254	rhamnose metabolic process
FY145_RS17740	COG2264	protein methyltransferase activity
FY145_RS17745	COG5001	Diguanylate cyclase
FY145_RS17760	COG4335	DNA alkylation repair
FY145_RS17765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY145_RS17770	COG4208	sulfate ABC transporter
FY145_RS17780	COG4150	thiosulfate binding
FY145_RS17785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY145_RS17800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY145_RS17810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY145_RS17820	COG1040	competence protein
FY145_RS17825	COG2226	methyltransferase
FY145_RS17840	COG0494	nUDIX hydrolase
FY145_RS17850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY145_RS17855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY145_RS17860	COG0653	protein targeting
FY145_RS17865	COG0697	spore germination
FY145_RS17930	COG2244	polysaccharide biosynthetic process
FY145_RS17945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY145_RS17955	COG3206	protein involved in exopolysaccharide biosynthesis
FY145_RS17955	COG0489	protein tyrosine kinase activity
FY145_RS17975	COG0438	transferase activity, transferring glycosyl groups
FY145_RS17980	COG0438	transferase activity, transferring glycosyl groups
FY145_RS17995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY145_RS18000	COG2273	Hydrolase Family 16
FY145_RS18000	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY145_RS18015	COG3842	ATPase activity
FY145_RS18020	COG3833	ABC-type maltose transport systems, permease component
FY145_RS18075	COG1396	sequence-specific DNA binding
FY145_RS18085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY145_RS18090	COG1129	ABC transporter
FY145_RS18095	COG4214	carbohydrate transport
FY145_RS18100	COG4213	ABC transporter substrate-binding protein
FY145_RS18115	COG0346	lactoylglutathione lyase activity
FY145_RS18120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY145_RS18120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY145_RS18125	COG4770	biotin carboxylase activity
FY145_RS18140	COG0625	glutathione transferase activity
FY145_RS18145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY145_RS18150	COG1396	sequence-specific DNA binding
FY145_RS18150	COG3800	Transcriptional regulator
FY145_RS18160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY145_RS18170	COG0300	oxidoreductase activity
FY145_RS18180	COG2096	Adenosyltransferase
FY145_RS18190	COG2086	electron transfer activity
FY145_RS18200	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY145_RS18210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY145_RS18215	COG0165	Argininosuccinate lyase
FY145_RS18250	COG2884	Cell division ATP-binding protein ftsE
FY145_RS18270	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY145_RS18280	COG0287	Prephenate dehydrogenase
FY145_RS18285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY145_RS18290	COG2226	methyltransferase
FY145_RS18295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY145_RS18315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY145_RS18320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY145_RS18360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY145_RS18365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY145_RS18375	COG4974	Belongs to the 'phage' integrase family
FY145_RS18380	COG0825	malonyl-CoA metabolic process
FY145_RS18385	COG3034	peptidoglycan biosynthetic process
FY145_RS18390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY145_RS18390	COG0425	Belongs to the sulfur carrier protein TusA family
FY145_RS18395	COG0523	cobalamin synthesis protein
FY145_RS18400	COG1686	Belongs to the peptidase S11 family
FY145_RS18405	COG1473	amidohydrolase
FY145_RS18415	COG4953	penicillin-binding protein 1C
FY145_RS18420	COG2373	Large extracellular alpha-helical protein
FY145_RS18425	COG2835	tetraacyldisaccharide 4'-kinase activity
FY145_RS18455	COG0482	sulfurtransferase activity
FY145_RS18470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY145_RS18485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY145_RS18490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY145_RS18495	COG0037	tRNA processing
FY145_RS18505	COG2885	chlorophyll binding
FY145_RS18510	COG0823	Involved in the tonB-independent uptake of proteins
FY145_RS18530	COG0824	Thioesterase
FY145_RS18540	COG0494	nUDIX hydrolase
FY145_RS18555	COG2255	four-way junction helicase activity
FY145_RS18560	COG0632	four-way junction helicase activity
FY145_RS18565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY145_RS18570	COG0840	transmembrane signaling receptor activity
FY145_RS18575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS18580	COG0217	transcriptional regulatory protein
FY145_RS18595	COG1692	metallophosphoesterase
FY145_RS18605	COG1253	flavin adenine dinucleotide binding
FY145_RS18640	COG3263	regulation of cellular component size
FY145_RS18645	COG0126	phosphoglycerate kinase activity
FY145_RS18650	COG3588	fructose-bisphosphate aldolase
FY145_RS18675	COG0254	rRNA binding
FY145_RS18680	COG1132	(ABC) transporter
FY145_RS18700	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS18730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY145_RS18735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY145_RS18740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY145_RS18745	COG0457	Tetratricopeptide repeat
FY145_RS18750	COG3750	Belongs to the UPF0335 family
FY145_RS18770	COG0469	pyruvate kinase activity
FY145_RS18775	COG3108	Peptidase M15
FY145_RS18780	COG2204	response regulator
FY145_RS18785	COG1164	Oligoendopeptidase f
FY145_RS18790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY145_RS18800	COG5310	Homospermidine synthase
FY145_RS18810	COG0737	Belongs to the 5'-nucleotidase family
FY145_RS18815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY145_RS18820	COG0330	HflC and HflK could
FY145_RS18845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY145_RS18850	COG2951	lytic endotransglycosylase activity
FY145_RS18865	COG2205	protein histidine kinase activity
FY145_RS18880	COG0067	glutamate synthase
FY145_RS18880	COG0069	glutamate synthase activity
FY145_RS18880	COG0070	glutamate synthase
FY145_RS18895	COG2205	protein histidine kinase activity
FY145_RS18900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY145_RS18905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY145_RS18915	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY145_RS18925	COG0252	asparaginase activity
FY145_RS18935	COG1027	Aspartate ammonia-lyase
FY145_RS18940	COG2186	Transcriptional regulator
FY145_RS18980	COG4176	ABC-type proline glycine betaine transport system permease component
FY145_RS18985	COG4175	Glycine betaine
FY145_RS18985	COG0517	IMP dehydrogenase activity
FY145_RS18990	COG2986	histidine ammonia-lyase
FY145_RS18995	COG1609	Transcriptional regulator
FY145_RS19015	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS19020	COG0673	inositol 2-dehydrogenase activity
FY145_RS19025	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS19050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY145_RS19095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS19105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS19110	COG0601	transmembrane transport
FY145_RS19115	COG0747	negative chemotaxis
FY145_RS19125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY145_RS19130	COG1454	alcohol dehydrogenase
FY145_RS19170	COG2307	Protein conserved in bacteria
FY145_RS19170	COG2308	Evidence 4 Homologs of previously reported genes of
FY145_RS19185	COG0488	(ABC) transporter
FY145_RS19190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY145_RS19195	COG2186	Transcriptional regulator
FY145_RS19210	COG1175	transmembrane transport
FY145_RS19215	COG0395	ABC-type sugar transport system, permease component
FY145_RS19225	COG3842	ATPase activity
FY145_RS19250	COG1304	FMN binding
FY145_RS19265	COG1063	alcohol dehydrogenase
FY145_RS19270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY145_RS19275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS19285	COG0765	amino acid transport
FY145_RS19290	COG0765	amino acid transport
FY145_RS19295	COG4221	oxidoreductase activity
FY145_RS19300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY145_RS19305	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS19310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS19325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY145_RS19340	COG0697	spore germination
FY145_RS19345	COG0697	spore germination
FY145_RS19350	COG0511	ligase activity, forming carbon-carbon bonds
FY145_RS19355	COG0439	Biotin carboxylase
FY145_RS19365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY145_RS19370	COG1984	allophanate hydrolase subunit 2
FY145_RS19375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY145_RS19380	COG3842	ATPase activity
FY145_RS19390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY145_RS19400	COG0436	Aminotransferase
FY145_RS19415	COG0840	transmembrane signaling receptor activity
FY145_RS19420	COG1070	Carbohydrate kinase
FY145_RS19425	COG1830	Aldolase
FY145_RS19430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY145_RS19435	COG0667	Aldo Keto reductase
FY145_RS19445	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS19450	COG1129	ABC transporter
FY145_RS19455	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS19500	COG0071	Belongs to the small heat shock protein (HSP20) family
FY145_RS19515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY145_RS19530	COG0395	ABC-type sugar transport system, permease component
FY145_RS19545	COG3842	ATPase activity
FY145_RS19560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY145_RS19560	COG1648	precorrin-2 dehydrogenase activity
FY145_RS19565	COG0243	molybdopterin cofactor binding
FY145_RS19575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY145_RS19580	COG1116	anion transmembrane transporter activity
FY145_RS19585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS19590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS19600	COG3707	response regulator
FY145_RS19605	COG1802	Transcriptional regulator
FY145_RS19610	COG1914	H( )-stimulated, divalent metal cation uptake system
FY145_RS19615	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY145_RS19620	COG4336	lyase activity
FY145_RS19625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY145_RS19630	COG4770	biotin carboxylase activity
FY145_RS19635	COG0366	Alpha amylase catalytic
FY145_RS19645	COG4771	TonB-dependent receptor
FY145_RS19650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY145_RS19670	COG1414	Transcriptional regulator
FY145_RS19675	COG1475	DNA binding
FY145_RS19680	COG1192	Involved in chromosome partitioning
FY145_RS19710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY145_RS19720	COG2986	histidine ammonia-lyase
FY145_RS19725	COG1228	amidohydrolase
FY145_RS19730	COG0402	S-adenosylhomocysteine deaminase activity
FY145_RS19770	COG4172	Belongs to the ABC transporter superfamily
FY145_RS19775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS19780	COG0601	transmembrane transport
FY145_RS19785	COG4166	transmembrane transport
FY145_RS19790	COG0395	ABC-type sugar transport system, permease component
FY145_RS19810	COG1566	PFAM secretion protein HlyD family protein
FY145_RS19825	COG2207	Transcriptional regulator
FY145_RS19830	COG1309	transcriptional regulator
FY145_RS19835	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS19860	COG1846	Transcriptional regulator
FY145_RS19865	COG0583	DNA-binding transcription factor activity
FY145_RS19870	COG2828	Protein conserved in bacteria
FY145_RS19885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS19900	COG0840	transmembrane signaling receptor activity
FY145_RS19920	COG1215	transferase activity, transferring glycosyl groups
FY145_RS19950	COG0583	DNA-binding transcription factor activity
FY145_RS19955	COG0346	lactoylglutathione lyase activity
FY145_RS19970	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY145_RS19990	COG0583	DNA-binding transcription factor activity
FY145_RS19995	COG0477	Major facilitator Superfamily
FY145_RS20005	COG2205	protein histidine kinase activity
FY145_RS20010	COG0745	RESPONSE REGULATOR receiver
FY145_RS20015	COG0671	phosphoesterase, PA-phosphatase related
FY145_RS20065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY145_RS20070	COG0156	8-amino-7-oxononanoate synthase activity
FY145_RS20075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY145_RS20080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY145_RS20085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY145_RS20100	COG0010	Belongs to the arginase family
FY145_RS20110	COG0697	spore germination
FY145_RS20115	COG0673	inositol 2-dehydrogenase activity
FY145_RS20135	COG0477	Major facilitator Superfamily
FY145_RS20150	COG2194	sulfuric ester hydrolase activity
FY145_RS20160	COG0583	DNA-binding transcription factor activity
FY145_RS20165	COG4774	siderophore transport
FY145_RS20180	COG1120	ATPase activity
FY145_RS20190	COG3474	cytochrome
FY145_RS20195	COG2137	regulation of response to DNA damage stimulus
FY145_RS20200	COG3386	PFAM SMP-30 Gluconolaconase
FY145_RS20210	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS20215	COG1129	ABC transporter
FY145_RS20220	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS20225	COG4585	Histidine kinase
FY145_RS20230	COG2197	response regulator
FY145_RS20240	COG2133	pyrroloquinoline quinone binding
FY145_RS20250	COG0500	methyltransferase
FY145_RS20255	COG0564	pseudouridine synthase activity
FY145_RS20270	COG4175	Glycine betaine
FY145_RS20270	COG3448	diguanylate cyclase activity
FY145_RS20275	COG4176	ABC-type proline glycine betaine transport system permease component
FY145_RS20290	COG0784	Response regulator, receiver
FY145_RS20290	COG4191	Histidine kinase
FY145_RS20295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY145_RS20300	COG0489	protein tyrosine kinase activity
FY145_RS20300	COG3206	protein involved in exopolysaccharide biosynthesis
FY145_RS20305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY145_RS20310	COG1215	transferase activity, transferring glycosyl groups
FY145_RS20315	COG1215	transferase activity, transferring glycosyl groups
FY145_RS20320	COG1215	transferase activity, transferring glycosyl groups
FY145_RS20325	COG0438	transferase activity, transferring glycosyl groups
FY145_RS20330	COG2273	Hydrolase Family 16
FY145_RS20335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY145_RS20340	COG2244	polysaccharide biosynthetic process
FY145_RS20345	COG0463	Glycosyl transferase, family 2
FY145_RS20350	COG2327	Polysaccharide pyruvyl transferase
FY145_RS20355	COG1215	transferase activity, transferring glycosyl groups
FY145_RS20375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY145_RS20380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS20395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY145_RS20395	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY145_RS20425	COG1523	belongs to the glycosyl hydrolase 13 family
FY145_RS20430	COG0033	Phosphoglucomutase
FY145_RS20435	COG0297	glycogen (starch) synthase activity
FY145_RS20440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY145_RS20445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY145_RS20450	COG0058	SHG alpha-glucan phosphorylase activity
FY145_RS20465	COG1794	racemase activity, acting on amino acids and derivatives
FY145_RS20470	COG1522	sequence-specific DNA binding
FY145_RS20480	COG2084	Dehydrogenase
FY145_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS20490	COG1063	alcohol dehydrogenase
FY145_RS20500	COG4988	ABC transporter
FY145_RS20505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY145_RS20515	COG1294	oxidase, subunit
FY145_RS20545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY145_RS20550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY145_RS20580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY145_RS20585	COG0539	negative regulation of cytoplasmic translation
FY145_RS20615	COG4221	oxidoreductase activity
FY145_RS20625	COG0747	negative chemotaxis
FY145_RS20630	COG0601	transmembrane transport
FY145_RS20635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS20640	COG0444	Belongs to the ABC transporter superfamily
FY145_RS20645	COG4608	Belongs to the ABC transporter superfamily
FY145_RS20650	COG0246	Mannitol dehydrogenase
FY145_RS20665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS20710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY145_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS20730	COG4993	Dehydrogenase
FY145_RS20735	COG3685	Protein conserved in bacteria
FY145_RS20765	COG0693	protein deglycase activity
FY145_RS20785	COG0189	ligase activity
FY145_RS20790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY145_RS20795	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY145_RS20810	COG0435	Glutathione S-transferase
FY145_RS20815	COG0583	DNA-binding transcription factor activity
FY145_RS20820	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS20825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS20830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS20835	COG1116	anion transmembrane transporter activity
FY145_RS20845	COG1522	sequence-specific DNA binding
FY145_RS20860	COG0784	Response regulator, receiver
FY145_RS20880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY145_RS20895	COG0019	diaminopimelate decarboxylase activity
FY145_RS20910	COG0527	aspartate kinase activity
FY145_RS20920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY145_RS20925	COG2890	protein-(glutamine-N5) methyltransferase activity
FY145_RS20935	COG0542	response to heat
FY145_RS20940	COG0739	heme binding
FY145_RS20940	COG0741	lytic transglycosylase activity
FY145_RS20940	COG1196	nuclear chromosome segregation
FY145_RS20980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY145_RS20990	COG1280	lysine exporter protein (LysE YggA)
FY145_RS21005	COG1309	transcriptional regulator
FY145_RS21010	COG4221	oxidoreductase activity
FY145_RS21015	COG1902	pentaerythritol trinitrate reductase activity
FY145_RS21020	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS21060	COG1278	Cold shock
FY145_RS21080	COG0753	catalase activity
FY145_RS21105	COG3920	Histidine kinase
FY145_RS21110	COG1280	lysine exporter protein (LysE YggA)
FY145_RS21130	COG0583	DNA-binding transcription factor activity
FY145_RS21165	COG0583	DNA-binding transcription factor activity
FY145_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS21180	COG1846	Transcriptional regulator
FY145_RS21200	COG2186	Transcriptional regulator
FY145_RS21210	COG1126	abc transporter atp-binding protein
FY145_RS21220	COG0765	amino acid transport
FY145_RS21225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS21240	COG0436	Aminotransferase
FY145_RS21245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS21275	COG0405	Gamma-glutamyltransferase
FY145_RS21285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY145_RS21290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS21295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS21305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS21310	COG0747	negative chemotaxis
FY145_RS21315	COG0747	negative chemotaxis
FY145_RS21325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS21335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS21345	COG1129	ABC transporter
FY145_RS21350	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS21355	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS21380	COG0667	Aldo Keto reductase
FY145_RS21395	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS21400	COG1129	ABC transporter
FY145_RS21405	COG4213	ABC transporter substrate-binding protein
FY145_RS21425	COG4608	Belongs to the ABC transporter superfamily
FY145_RS21430	COG0444	Belongs to the ABC transporter superfamily
FY145_RS21435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS21440	COG0601	transmembrane transport
FY145_RS21445	COG0747	negative chemotaxis
FY145_RS21470	COG0765	amino acid transport
FY145_RS21475	COG4597	amino acid ABC transporter
FY145_RS21480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS21495	COG3177	Filamentation induced by cAMP protein fic
FY145_RS21520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS21550	COG3209	COG3209 Rhs family protein
FY145_RS21570	COG0745	RESPONSE REGULATOR receiver
FY145_RS21580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS21585	COG0577	efflux transmembrane transporter activity
FY145_RS21585	COG1136	(ABC) transporter
FY145_RS21595	COG1733	regulation of RNA biosynthetic process
FY145_RS21630	COG0534	Mate efflux family protein
FY145_RS21645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY145_RS21650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY145_RS21660	COG1566	PFAM secretion protein HlyD family protein
FY145_RS21670	COG0625	glutathione transferase activity
FY145_RS21675	COG4221	oxidoreductase activity
FY145_RS21685	COG2376	Dihydroxyacetone kinase
FY145_RS21690	COG1522	sequence-specific DNA binding
FY145_RS21710	COG0431	NADPH-dependent FMN reductase
FY145_RS21720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS21730	COG4172	Belongs to the ABC transporter superfamily
FY145_RS21735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS21755	COG0277	FAD linked oxidase domain protein
FY145_RS21775	COG0778	Nitroreductase
FY145_RS21805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY145_RS21830	COG2318	DinB family
FY145_RS21835	COG0583	DNA-binding transcription factor activity
FY145_RS21850	COG1335	isochorismatase
FY145_RS21875	COG3842	ATPase activity
FY145_RS21880	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS21885	COG1177	transmembrane transport
FY145_RS21890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY145_RS21900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY145_RS21915	COG1120	ATPase activity
FY145_RS21920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS21925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS21930	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FY145_RS21935	COG4774	siderophore transport
FY145_RS21935	COG1629	transport
FY145_RS21940	COG4702	Belongs to the UPF0303 family
FY145_RS21960	COG1024	Enoyl-CoA hydratase
FY145_RS21965	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS21970	COG1653	transport
FY145_RS21975	COG1175	transmembrane transport
FY145_RS21980	COG0395	ABC-type sugar transport system, permease component
FY145_RS21985	COG3842	ATPase activity
FY145_RS22015	COG3474	cytochrome
FY145_RS22020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY145_RS22025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY145_RS22030	COG1845	cytochrome c oxidase, subunit III
FY145_RS22055	COG0577	efflux transmembrane transporter activity
FY145_RS22055	COG1136	(ABC) transporter
FY145_RS22115	COG3842	ATPase activity
FY145_RS22125	COG1177	transmembrane transport
FY145_RS22130	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS22145	COG1940	carbohydrate kinase activity
FY145_RS22165	COG1069	ribulokinase activity
FY145_RS22170	COG1349	DNA-binding transcription factor activity
FY145_RS22175	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS22200	COG0395	ABC-type sugar transport system, permease component
FY145_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS22225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY145_RS22235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY145_RS22245	COG0477	Major facilitator Superfamily
FY145_RS22295	COG1733	regulation of RNA biosynthetic process
FY145_RS22330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY145_RS22335	COG3938	Belongs to the proline racemase family
FY145_RS22340	COG4176	ABC-type proline glycine betaine transport system permease component
FY145_RS22350	COG3448	diguanylate cyclase activity
FY145_RS22350	COG4175	Glycine betaine
FY145_RS22360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS22370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS22380	COG0047	phosphoribosylformylglycinamidine synthase activity
FY145_RS22385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS22395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY145_RS22395	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY145_RS22405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY145_RS22430	COG1309	transcriptional regulator
FY145_RS22445	COG1136	(ABC) transporter
FY145_RS22460	COG1063	alcohol dehydrogenase
FY145_RS22470	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS22480	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS22500	COG0477	Major facilitator Superfamily
FY145_RS22630	COG5001	Diguanylate cyclase
FY145_RS22630	COG3300	MHYT domain
FY145_RS22655	COG1253	flavin adenine dinucleotide binding
FY145_RS22670	COG3842	ATPase activity
FY145_RS22675	COG0395	ABC-type sugar transport system, permease component
FY145_RS22680	COG1175	transmembrane transport
FY145_RS22685	COG1653	transport
FY145_RS22695	COG0673	inositol 2-dehydrogenase activity
FY145_RS22700	COG1609	Transcriptional regulator
FY145_RS22715	COG0583	DNA-binding transcription factor activity
FY145_RS22725	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS22730	COG1129	ABC transporter
FY145_RS22735	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS22740	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS22745	COG1609	Transcriptional regulator
FY145_RS22755	COG0673	inositol 2-dehydrogenase activity
FY145_RS22815	COG0714	Associated with various cellular activities
FY145_RS22820	COG3256	nitric oxide reductase
FY145_RS22855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY145_RS22860	COG3189	MarR family transcriptional regulator
FY145_RS22870	COG0826	peptidase U32
FY145_RS22905	COG4459	periplasmic nitrate reductase
FY145_RS22920	COG0243	molybdopterin cofactor binding
FY145_RS22930	COG3005	denitrification pathway
FY145_RS22945	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS22950	COG1535	isochorismatase
FY145_RS22950	COG3433	isochorismatase activity
FY145_RS22955	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY145_RS22960	COG1169	isochorismate synthase
FY145_RS22970	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY145_RS22970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY145_RS22975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY145_RS22985	COG2375	cellular response to nickel ion
FY145_RS22995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS23000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS23010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS23020	COG1629	transport
FY145_RS23020	COG4774	siderophore transport
FY145_RS23025	COG1960	acyl-CoA dehydrogenase activity
FY145_RS23030	COG0583	DNA-binding transcription factor activity
FY145_RS23035	COG1609	Transcriptional regulator
FY145_RS23045	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS23055	COG3842	ATPase activity
FY145_RS23065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY145_RS23070	COG0583	DNA-binding transcription factor activity
FY145_RS23075	COG2814	Major facilitator Superfamily
FY145_RS23080	COG1473	amidohydrolase
FY145_RS23095	COG0747	negative chemotaxis
FY145_RS23100	COG0601	transmembrane transport
FY145_RS23105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS23110	COG0444	Belongs to the ABC transporter superfamily
FY145_RS23115	COG4608	Belongs to the ABC transporter superfamily
FY145_RS23120	COG0583	DNA-binding transcription factor activity
FY145_RS23125	COG0747	negative chemotaxis
FY145_RS23135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS23140	COG0154	amidase activity
FY145_RS23145	COG0693	protein deglycase activity
FY145_RS23155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS23160	COG0601	transmembrane transport
FY145_RS23170	COG1473	amidohydrolase
FY145_RS23175	COG4172	Belongs to the ABC transporter superfamily
FY145_RS23180	COG2390	Transcriptional regulator
FY145_RS23190	COG1175	transmembrane transport
FY145_RS23195	COG0395	ABC-type sugar transport system, permease component
FY145_RS23245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY145_RS23265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY145_RS23270	COG1414	Transcriptional regulator
FY145_RS23275	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS23285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY145_RS23290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY145_RS23295	COG1121	(ABC) transporter
FY145_RS23300	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY145_RS23310	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY145_RS23315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY145_RS23320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY145_RS23325	COG3273	potassium ion transport
FY145_RS23325	COG0471	metal ion transport
FY145_RS23330	COG1253	flavin adenine dinucleotide binding
FY145_RS23335	COG1309	transcriptional regulator
FY145_RS23355	COG1609	Transcriptional regulator
FY145_RS23360	COG1070	Carbohydrate kinase
FY145_RS23365	COG2115	Belongs to the xylose isomerase family
FY145_RS23375	COG0778	Nitroreductase
FY145_RS23380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY145_RS23385	COG2011	ABC-type metal ion transport system permease component
FY145_RS23395	COG3300	MHYT domain
FY145_RS23395	COG5001	Diguanylate cyclase
FY145_RS23400	COG1054	Belongs to the UPF0176 family
FY145_RS23410	COG2954	triphosphatase activity
FY145_RS23415	COG0800	Aldolase
FY145_RS23435	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY145_RS23475	COG0523	cobalamin synthesis protein
FY145_RS23485	COG1846	Transcriptional regulator
FY145_RS23490	COG1609	Transcriptional regulator
FY145_RS23495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY145_RS23505	COG3718	enzyme involved in inositol metabolism
FY145_RS23515	COG3962	Belongs to the TPP enzyme family
FY145_RS23520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS23535	COG0411	ABC transporter
FY145_RS23550	COG0683	leucine binding
FY145_RS23565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS23575	COG0747	negative chemotaxis
FY145_RS23580	COG4172	Belongs to the ABC transporter superfamily
FY145_RS23605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY145_RS23610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY145_RS23615	COG1126	abc transporter atp-binding protein
FY145_RS23620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS23625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS23630	COG0765	amino acid transport
FY145_RS23635	COG0765	amino acid transport
FY145_RS23640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY145_RS23645	COG3485	protocatechuate 3,4-dioxygenase
FY145_RS23650	COG3485	protocatechuate 3,4-dioxygenase
FY145_RS23655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY145_RS23665	COG0583	DNA-binding transcription factor activity
FY145_RS23680	COG1414	Transcriptional regulator
FY145_RS23690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY145_RS23695	COG0183	Belongs to the thiolase family
FY145_RS23700	COG1609	Transcriptional regulator
FY145_RS23715	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS23720	COG0673	inositol 2-dehydrogenase activity
FY145_RS23730	COG1609	Transcriptional regulator
FY145_RS23735	COG0395	ABC-type sugar transport system, permease component
FY145_RS23740	COG1175	transmembrane transport
FY145_RS23745	COG3842	ATPase activity
FY145_RS23755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY145_RS23775	COG2814	Major facilitator Superfamily
FY145_RS23780	COG4774	siderophore transport
FY145_RS23785	COG3712	iron ion homeostasis
FY145_RS23795	COG1940	carbohydrate kinase activity
FY145_RS23800	COG0584	glycerophosphoryl diester phosphodiesterase
FY145_RS23805	COG0300	oxidoreductase activity
FY145_RS23820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY145_RS23840	COG0667	Aldo Keto reductase
FY145_RS23845	COG0583	DNA-binding transcription factor activity
FY145_RS23855	COG1132	(ABC) transporter
FY145_RS23870	COG1442	glycosyl transferase family 8
FY145_RS23870	COG1216	Glycosyl transferase, family 2
FY145_RS23875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FY145_RS23885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FY145_RS23905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY145_RS23910	COG3754	Rhamnan synthesis protein F
FY145_RS23925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY145_RS23930	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY145_RS23935	COG1088	dTDP-glucose 4,6-dehydratase activity
FY145_RS23940	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY145_RS23945	COG0210	DNA helicase
FY145_RS23955	COG1609	Transcriptional regulator
FY145_RS23960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY145_RS23960	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY145_RS23975	COG0395	ABC-type sugar transport system, permease component
FY145_RS23980	COG3842	ATPase activity
FY145_RS23990	COG0444	Belongs to the ABC transporter superfamily
FY145_RS23995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS24000	COG0601	transmembrane transport
FY145_RS24005	COG2186	Transcriptional regulator
FY145_RS24025	COG3300	MHYT domain
FY145_RS24025	COG5001	Diguanylate cyclase
FY145_RS24030	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS24040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY145_RS24050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY145_RS24055	COG0306	phosphate transporter
FY145_RS24060	COG1392	Phosphate transport regulator
FY145_RS24075	COG1566	PFAM secretion protein HlyD family protein
FY145_RS24080	COG0745	RESPONSE REGULATOR receiver
FY145_RS24085	COG2205	protein histidine kinase activity
FY145_RS24100	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY145_RS24115	COG4774	siderophore transport
FY145_RS24125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS24130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS24135	COG1120	ATPase activity
FY145_RS24140	COG0583	DNA-binding transcription factor activity
FY145_RS24150	COG3119	arylsulfatase activity
FY145_RS24155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY145_RS24160	COG3842	ATPase activity
FY145_RS24165	COG0165	Argininosuccinate lyase
FY145_RS24170	COG0395	ABC-type sugar transport system, permease component
FY145_RS24175	COG1175	transmembrane transport
FY145_RS24180	COG2182	Extracellular solute-binding protein
FY145_RS24185	COG1940	carbohydrate kinase activity
FY145_RS24210	COG1486	melibiose metabolic process
FY145_RS24215	COG0747	negative chemotaxis
FY145_RS24220	COG0601	transmembrane transport
FY145_RS24225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS24230	COG4172	Belongs to the ABC transporter superfamily
FY145_RS24235	COG1486	melibiose metabolic process
FY145_RS24240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY145_RS24245	COG1129	ABC transporter
FY145_RS24245	COG0842	Transport permease protein
FY145_RS24250	COG0842	Transport permease protein
FY145_RS24265	COG0784	Response regulator, receiver
FY145_RS24270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY145_RS24280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS24285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY145_RS24300	COG0765	amino acid transport
FY145_RS24310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS24320	COG3938	Belongs to the proline racemase family
FY145_RS24335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS24340	COG0765	amino acid transport
FY145_RS24345	COG0765	amino acid transport
FY145_RS24355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY145_RS24370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY145_RS24390	COG3383	formate dehydrogenase (NAD+) activity
FY145_RS24400	COG2223	nitrite transmembrane transporter activity
FY145_RS24405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY145_RS24415	COG2186	Transcriptional regulator
FY145_RS24420	COG0747	negative chemotaxis
FY145_RS24425	COG0601	transmembrane transport
FY145_RS24430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS24435	COG4172	Belongs to the ABC transporter superfamily
FY145_RS24440	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS24450	COG2186	Transcriptional regulator
FY145_RS24455	COG0747	negative chemotaxis
FY145_RS24460	COG0601	transmembrane transport
FY145_RS24465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS24470	COG0405	Gamma-glutamyltransferase
FY145_RS24480	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS24490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY145_RS24495	COG0395	ABC-type sugar transport system, permease component
FY145_RS24515	COG3237	CsbD-like
FY145_RS24525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY145_RS24530	COG3181	Tripartite tricarboxylate transporter family receptor
FY145_RS24535	COG5265	(ABC) transporter
FY145_RS24540	COG0488	(ABC) transporter
FY145_RS24565	COG1049	propionate catabolic process, 2-methylcitrate cycle
FY145_RS24570	COG0110	maltose O-acetyltransferase activity
FY145_RS24580	COG1063	alcohol dehydrogenase
FY145_RS24585	COG3284	Transcriptional regulator
FY145_RS24605	COG1129	ABC transporter
FY145_RS24610	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS24615	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS24625	COG0572	uridine kinase
FY145_RS24630	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS24655	COG4178	(ABC) transporter
FY145_RS24690	COG0640	Transcriptional regulator
FY145_RS24705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY145_RS24710	COG1192	Involved in chromosome partitioning
FY145_RS24715	COG1475	DNA binding
FY145_RS24720	COG0640	Transcriptional regulator
FY145_RS24735	COG1126	abc transporter atp-binding protein
FY145_RS24745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS24750	COG1609	Transcriptional regulator
FY145_RS24785	COG3239	Fatty acid desaturase
FY145_RS24795	COG1278	Cold shock
FY145_RS24870	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY145_RS24870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY145_RS24910	COG4191	Histidine kinase
FY145_RS24925	COG0640	Transcriptional regulator
FY145_RS24955	COG4977	sequence-specific DNA binding
FY145_RS24960	COG2211	Major facilitator Superfamily
FY145_RS24965	COG2807	transmembrane transport
FY145_RS24970	COG1846	Transcriptional regulator
FY145_RS24985	COG2814	Major facilitator Superfamily
FY145_RS25015	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY145_RS25030	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY145_RS25035	COG0583	DNA-binding transcription factor activity
FY145_RS25050	COG0071	Belongs to the small heat shock protein (HSP20) family
FY145_RS25100	COG3838	Conjugal transfer protein Trbc
FY145_RS25105	COG3702	type iv secretory pathway
FY145_RS25110	COG3451	type IV secretory pathway VirB4
FY145_RS25125	COG3704	protein secretion by the type IV secretion system
FY145_RS25135	COG3736	Type IV secretory pathway, component VirB8
FY145_RS25140	COG3504	Conjugal transfer protein
FY145_RS25145	COG2948	multi-organism process
FY145_RS25150	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY145_RS25255	COG3831	ATPase activity
FY145_RS25270	COG3505	Type IV secretory pathway VirD4
FY145_RS25295	COG0583	DNA-binding transcription factor activity
FY145_RS25340	COG0745	RESPONSE REGULATOR receiver
FY145_RS25380	COG3842	ATPase activity
FY145_RS25385	COG4208	sulfate ABC transporter
FY145_RS25390	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS25410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY145_RS25415	COG1942	4-Oxalocrotonate Tautomerase
FY145_RS25425	COG3971	2-oxopent-4-enoate hydratase activity
FY145_RS25435	COG1414	Transcriptional regulator
FY145_RS25445	COG1137	ATPase activity
FY145_RS25460	COG4177	L-phenylalanine transmembrane transporter activity
FY145_RS25480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY145_RS25485	COG1175	transmembrane transport
FY145_RS25490	COG0395	ABC-type sugar transport system, permease component
FY145_RS25500	COG0366	Alpha amylase catalytic
FY145_RS25505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY145_RS25510	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS25515	COG3842	ATPase activity
FY145_RS25525	COG1940	carbohydrate kinase activity
FY145_RS25530	COG0395	ABC-type sugar transport system, permease component
FY145_RS25540	COG2182	Extracellular solute-binding protein
FY145_RS25545	COG0673	inositol 2-dehydrogenase activity
FY145_RS25575	COG1126	abc transporter atp-binding protein
FY145_RS25580	COG0765	amino acid transport
FY145_RS25585	COG0765	amino acid transport
FY145_RS25595	COG4608	Belongs to the ABC transporter superfamily
FY145_RS25605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS25620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY145_RS25625	COG0583	DNA-binding transcription factor activity
FY145_RS25630	COG2423	ornithine cyclodeaminase activity
FY145_RS25640	COG1957	nucleoside hydrolase
FY145_RS25650	COG1309	transcriptional regulator
FY145_RS25660	COG1335	isochorismatase
FY145_RS25665	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS25705	COG0251	oxidation-reduction process
FY145_RS25710	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY145_RS25765	COG4215	(ABC) transporter
FY145_RS25775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS25790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS25800	COG0747	negative chemotaxis
FY145_RS25805	COG0583	DNA-binding transcription factor activity
FY145_RS25820	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY145_RS25855	COG0477	Major facilitator Superfamily
FY145_RS25865	COG0395	ABC-type sugar transport system, permease component
FY145_RS25870	COG1175	transmembrane transport
FY145_RS25875	COG3842	ATPase activity
FY145_RS25885	COG4948	Mandelate Racemase Muconate Lactonizing
FY145_RS25895	COG1414	Transcriptional regulator
FY145_RS25900	COG0583	DNA-binding transcription factor activity
FY145_RS25935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY145_RS25945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY145_RS25970	COG1129	ABC transporter
FY145_RS25990	COG2272	Belongs to the type-B carboxylesterase lipase family
FY145_RS26000	COG2271	Major facilitator Superfamily
FY145_RS26005	COG0583	DNA-binding transcription factor activity
FY145_RS26030	COG1129	ABC transporter
FY145_RS26040	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS26045	COG1940	carbohydrate kinase activity
FY145_RS26070	COG2084	Dehydrogenase
FY145_RS26075	COG3622	Belongs to the hyi family
FY145_RS26080	COG3386	PFAM SMP-30 Gluconolaconase
FY145_RS26090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY145_RS26100	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS26140	COG1846	Transcriptional regulator
FY145_RS26160	COG3706	GGDEF domain
FY145_RS26175	COG0477	Major facilitator Superfamily
FY145_RS26180	COG1012	belongs to the aldehyde dehydrogenase family
FY145_RS26190	COG1024	Enoyl-CoA hydratase
FY145_RS26195	COG1960	acyl-CoA dehydrogenase activity
FY145_RS26205	COG1063	alcohol dehydrogenase
FY145_RS26220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY145_RS26225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY145_RS26240	COG3971	2-oxopent-4-enoate hydratase activity
FY145_RS26245	COG3485	protocatechuate 3,4-dioxygenase
FY145_RS26250	COG1802	Transcriptional regulator
FY145_RS26310	COG2207	Transcriptional regulator
FY145_RS26395	COG1695	Transcriptional regulator
FY145_RS26405	COG0583	DNA-binding transcription factor activity
FY145_RS26410	COG1335	isochorismatase
FY145_RS26420	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS26425	COG0583	DNA-binding transcription factor activity
FY145_RS26430	COG1902	pentaerythritol trinitrate reductase activity
FY145_RS26435	COG0583	DNA-binding transcription factor activity
FY145_RS26480	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS26485	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS26490	COG1335	isochorismatase
FY145_RS26500	COG1309	transcriptional regulator
FY145_RS26505	COG4604	ABC transporter, ATP-binding protein
FY145_RS26510	COG4605	iron ion homeostasis
FY145_RS26515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY145_RS26525	COG2132	Multicopper oxidase
FY145_RS26530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY145_RS26580	COG1695	Transcriptional regulator
FY145_RS26615	COG2132	Multicopper oxidase
FY145_RS26650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY145_RS26670	COG1192	Involved in chromosome partitioning
FY145_RS26675	COG1475	DNA binding
FY145_RS26680	COG0640	Transcriptional regulator
FY145_RS26685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY145_RS26715	COG2211	Major facilitator Superfamily
FY145_RS26765	COG1051	belongs to the nudix hydrolase family
FY145_RS26810	COG1475	DNA binding
FY145_RS26835	COG2824	Alkylphosphonate utilization operon protein PhnA
FY145_RS26855	COG1280	lysine exporter protein (LysE YggA)
FY145_RS26870	COG5489	Protein of unknown function (DUF736)
FY145_RS26935	COG1879	ABC-type sugar transport system periplasmic component
FY145_RS26940	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS26960	COG1280	lysine exporter protein (LysE YggA)
FY145_RS27045	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY145_RS27060	COG0747	negative chemotaxis
FY145_RS27065	COG0444	Belongs to the ABC transporter superfamily
FY145_RS27080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS27085	COG0584	glycerophosphoryl diester phosphodiesterase
FY145_RS27090	COG0483	inositol monophosphate 1-phosphatase activity
FY145_RS27155	COG3161	chorismate lyase activity
FY145_RS27380	COG2222	sugar isomerase
FY145_RS27390	COG0006	proline dipeptidase activity
FY145_RS27410	COG1177	transmembrane transport
FY145_RS27415	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY145_RS27420	COG3842	ATPase activity
FY145_RS27450	COG3842	ATPase activity
FY145_RS27455	COG0006	proline dipeptidase activity
FY145_RS27475	COG0300	oxidoreductase activity
FY145_RS27480	COG0129	dihydroxy-acid dehydratase activity
FY145_RS27485	COG0667	Aldo Keto reductase
FY145_RS27495	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS27505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS27510	COG0601	transmembrane transport
FY145_RS27515	COG4172	Belongs to the ABC transporter superfamily
FY145_RS27525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY145_RS27560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS27595	COG3701	Conjugal transfer protein
FY145_RS27600	COG3846	protein secretion by the type IV secretion system
FY145_RS27610	COG5314	conjugation
FY145_RS27615	COG3451	type IV secretory pathway VirB4
FY145_RS27630	COG4962	Type ii secretion system protein e
FY145_RS27640	COG1192	Involved in chromosome partitioning
FY145_RS27645	COG1475	DNA binding
FY145_RS27650	COG0640	Transcriptional regulator
FY145_RS27655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY145_RS27700	COG0583	DNA-binding transcription factor activity
FY145_RS27710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY145_RS27715	COG1116	anion transmembrane transporter activity
FY145_RS27720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY145_RS27730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS27735	COG1028	Short-chain dehydrogenase reductase Sdr
FY145_RS27765	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY145_RS27770	COG1129	ABC transporter
FY145_RS27795	COG4172	Belongs to the ABC transporter superfamily
FY145_RS27800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS27805	COG0601	transmembrane transport
FY145_RS27815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS27820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS27825	COG0583	DNA-binding transcription factor activity
FY145_RS27835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY145_RS27850	COG1132	(ABC) transporter
FY145_RS27855	COG4172	Belongs to the ABC transporter superfamily
FY145_RS27860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS27880	COG1082	Xylose isomerase domain protein TIM barrel
FY145_RS27885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY145_RS27890	COG0019	diaminopimelate decarboxylase activity
FY145_RS27900	COG1475	DNA binding
FY145_RS27910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY145_RS28005	COG1475	DNA binding
FY145_RS28030	COG2824	Alkylphosphonate utilization operon protein PhnA
FY145_RS28055	COG5489	Protein of unknown function (DUF736)
FY145_RS28120	COG0583	DNA-binding transcription factor activity
FY145_RS28125	COG1126	abc transporter atp-binding protein
FY145_RS28130	COG0765	amino acid transport
FY145_RS28135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY145_RS28140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS28145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY145_RS28205	COG0584	glycerophosphoryl diester phosphodiesterase
FY145_RS28215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS28230	COG0444	Belongs to the ABC transporter superfamily
FY145_RS28255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY145_RS28260	COG0601	transmembrane transport
FY145_RS28275	COG0444	Belongs to the ABC transporter superfamily
FY145_RS28280	COG0747	negative chemotaxis
FY145_RS28290	COG2390	Transcriptional regulator
FY145_RS28335	COG0145	ligase activity
FY145_RS28345	COG0583	DNA-binding transcription factor activity
FY145_RS28390	COG3701	Conjugal transfer protein
FY145_RS28395	COG3846	protein secretion by the type IV secretion system
FY145_RS28410	COG3451	type IV secretory pathway VirB4
FY145_RS28425	COG4962	Type ii secretion system protein e