locus-tag	class	description
FY146_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY146_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY146_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY146_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY146_RS00025	COG1420	regulation of RNA biosynthetic process
FY146_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY146_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY146_RS00050	COG1137	ATPase activity
FY146_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY146_RS00065	COG0616	signal peptide processing
FY146_RS00070	COG0776	regulation of translation
FY146_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY146_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY146_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY146_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY146_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY146_RS00115	COG0728	peptidoglycan biosynthetic process
FY146_RS00125	COG0180	Tryptophanyl-tRNA synthetase
FY146_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY146_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
FY146_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY146_RS00165	COG1702	phosphate starvation-inducible protein PhoH
FY146_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY146_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY146_RS00185	COG1396	sequence-specific DNA binding
FY146_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY146_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY146_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS00210	COG0242	peptide deformylase activity
FY146_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY146_RS00220	COG0101	tRNA pseudouridine synthase activity
FY146_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_RS00235	COG2171	N-acyltransferase activity
FY146_RS00245	COG0840	transmembrane signaling receptor activity
FY146_RS00250	COG1957	nucleoside hydrolase
FY146_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY146_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY146_RS00295	COG0706	membrane insertase activity
FY146_RS00300	COG0594	ribonuclease P activity
FY146_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY146_RS00310	COG0840	transmembrane signaling receptor activity
FY146_RS00325	COG2226	methyltransferase
FY146_RS00330	COG3842	ATPase activity
FY146_RS00335	COG1175	transmembrane transport
FY146_RS00340	COG0395	ABC-type sugar transport system, permease component
FY146_RS00355	COG0427	acetyl-CoA hydrolase
FY146_RS00365	COG3938	Belongs to the proline racemase family
FY146_RS00370	COG0418	dihydroorotase activity
FY146_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY146_RS00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY146_RS00400	COG0166	Belongs to the GPI family
FY146_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
FY146_RS00410	COG3842	ATPase activity
FY146_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_RS00425	COG4774	siderophore transport
FY146_RS00470	COG2326	polyphosphate kinase activity
FY146_RS00475	COG5002	protein histidine kinase activity
FY146_RS00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY146_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
FY146_RS00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY146_RS00500	COG0704	Plays a role in the regulation of phosphate uptake
FY146_RS00505	COG0745	RESPONSE REGULATOR receiver
FY146_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY146_RS00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY146_RS00530	COG2967	ApaG domain
FY146_RS00540	COG0717	Belongs to the dCTP deaminase family
FY146_RS00550	COG0582	viral genome integration into host DNA
FY146_RS00575	COG0419	ATPase involved in DNA repair
FY146_RS00595	COG1396	sequence-specific DNA binding
FY146_RS00635	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FY146_RS00640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY146_RS00690	COG0167	dihydroorotate dehydrogenase activity
FY146_RS00725	COG1959	2 iron, 2 sulfur cluster binding
FY146_RS00730	COG1201	RNA secondary structure unwinding
FY146_RS00760	COG1960	acyl-CoA dehydrogenase activity
FY146_RS00765	COG0183	Belongs to the thiolase family
FY146_RS00775	COG1024	Enoyl-CoA hydratase
FY146_RS00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY146_RS00800	COG1320	monovalent cation:proton antiporter activity
FY146_RS00805	COG2212	antiporter activity
FY146_RS00810	COG1863	multisubunit Na H antiporter MnhE subunit
FY146_RS00815	COG0651	ATP synthesis coupled electron transport
FY146_RS00820	COG1006	Multisubunit Na H antiporter MnhC subunit
FY146_RS00825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY146_RS00825	COG2111	Na H antiporter
FY146_RS00835	COG0840	transmembrane signaling receptor activity
FY146_RS00845	COG0745	RESPONSE REGULATOR receiver
FY146_RS00850	COG2198	Histidine kinase
FY146_RS00850	COG0643	Histidine kinase
FY146_RS00855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY146_RS00860	COG2201	protein-glutamate methylesterase activity
FY146_RS00865	COG0745	RESPONSE REGULATOR receiver
FY146_RS00870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY146_RS00880	COG1766	The M ring may be actively involved in energy transduction
FY146_RS00885	COG2771	luxR family
FY146_RS00895	COG2972	Histidine kinase
FY146_RS00895	COG0840	transmembrane signaling receptor activity
FY146_RS00900	COG2198	Histidine kinase
FY146_RS00900	COG0784	Response regulator, receiver
FY146_RS00900	COG2205	protein histidine kinase activity
FY146_RS00905	COG1970	mechanosensitive ion channel activity
FY146_RS00910	COG0436	Aminotransferase
FY146_RS00925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY146_RS00930	COG0424	maF-like protein
FY146_RS00935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY146_RS00945	COG5328	Belongs to the UPF0262 family
FY146_RS00950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY146_RS00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY146_RS01095	COG5484	DNA packaging
FY146_RS01095	COG3728	DNA packaging
FY146_RS01230	COG0582	viral genome integration into host DNA
FY146_RS01240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY146_RS01250	COG1338	Plays a role in the flagellum-specific transport system
FY146_RS01260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY146_RS01270	COG1706	bacterial-type flagellum-dependent cell motility
FY146_RS01275	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY146_RS01280	COG4786	Flagellar basal body rod
FY146_RS01285	COG1677	Flagellar hook-basal body complex protein FliE
FY146_RS01290	COG1558	bacterial-type flagellum-dependent cell motility
FY146_RS01295	COG1815	bacterial-type flagellum-dependent cell motility
FY146_RS01305	COG1157	protein secretion by the type III secretion system
FY146_RS01310	COG4786	Flagellar basal body rod
FY146_RS01320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY146_RS01325	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_RS01330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_RS01335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_RS01340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY146_RS01360	COG1360	Flagellar Motor Protein
FY146_RS01405	COG5443	negative regulation of bacterial-type flagellum assembly
FY146_RS01410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY146_RS01420	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY146_RS01460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY146_RS01465	COG1609	Transcriptional regulator
FY146_RS01470	COG1653	transport
FY146_RS01475	COG1175	transmembrane transport
FY146_RS01480	COG0395	ABC-type sugar transport system, permease component
FY146_RS01485	COG0366	Alpha amylase catalytic
FY146_RS01490	COG3842	ATPase activity
FY146_RS01505	COG0129	dihydroxy-acid dehydratase activity
FY146_RS01510	COG0363	glucosamine-6-phosphate deaminase activity
FY146_RS01515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY146_RS01520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS01530	COG2081	HI0933 family
FY146_RS01550	COG2224	Isocitrate lyase
FY146_RS01565	COG3842	ATPase activity
FY146_RS01570	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS01575	COG1177	transmembrane transport
FY146_RS01590	COG2205	protein histidine kinase activity
FY146_RS01600	COG0248	Ppx GppA phosphatase
FY146_RS01605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY146_RS01610	COG0477	Major facilitator Superfamily
FY146_RS01640	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY146_RS01645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY146_RS01655	COG0142	geranyltranstransferase activity
FY146_RS01680	COG0752	glycyl-tRNA synthetase alpha subunit
FY146_RS01690	COG1704	LemA family
FY146_RS01695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY146_RS01705	COG0751	glycine-tRNA ligase activity
FY146_RS01710	COG1683	Conserved Protein
FY146_RS01715	COG0840	transmembrane signaling receptor activity
FY146_RS01725	COG0151	Belongs to the GarS family
FY146_RS01730	COG2183	response to ionizing radiation
FY146_RS01735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_RS01760	COG0583	DNA-binding transcription factor activity
FY146_RS01780	COG0306	phosphate transporter
FY146_RS01790	COG0561	phosphatase activity
FY146_RS01795	COG0438	transferase activity, transferring glycosyl groups
FY146_RS01800	COG2186	Transcriptional regulator
FY146_RS01815	COG0583	DNA-binding transcription factor activity
FY146_RS01820	COG0277	FAD linked oxidase domain protein
FY146_RS01825	COG0277	FAD linked oxidase domain protein
FY146_RS01830	COG0247	lactate metabolic process
FY146_RS01840	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS01845	COG2818	Glycosylase
FY146_RS01855	COG2855	membrane
FY146_RS01860	COG0583	DNA-binding transcription factor activity
FY146_RS01890	COG0124	histidyl-tRNA synthetase
FY146_RS01900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY146_RS01905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY146_RS01910	COG2259	Doxx family
FY146_RS01920	COG0459	protein refolding
FY146_RS01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY146_RS01935	COG0196	riboflavin kinase activity
FY146_RS01940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY146_RS01950	COG0590	tRNA wobble adenosine to inosine editing
FY146_RS01955	COG1187	pseudouridine synthase activity
FY146_RS01960	COG0742	ribosomal rna small subunit methyltransferase
FY146_RS01965	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_RS01975	COG0312	modulator of DNA gyrase
FY146_RS01980	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS01990	COG1519	Transferase
FY146_RS02000	COG1663	tetraacyldisaccharide 4'-kinase activity
FY146_RS02010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY146_RS02015	COG0745	RESPONSE REGULATOR receiver
FY146_RS02020	COG3300	MHYT domain
FY146_RS02020	COG5001	Diguanylate cyclase
FY146_RS02025	COG3386	PFAM SMP-30 Gluconolaconase
FY146_RS02030	COG0800	Aldolase
FY146_RS02035	COG3734	2-keto-3-deoxy-galactonokinase
FY146_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS02045	COG1414	Transcriptional regulator
FY146_RS02050	COG2197	response regulator
FY146_RS02065	COG0598	Magnesium transport protein CorA
FY146_RS02070	COG3158	transport of potassium into the cell
FY146_RS02085	COG0356	it plays a direct role in the translocation of protons across the membrane
FY146_RS02095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY146_RS02100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY146_RS02115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY146_RS02135	COG0009	L-threonylcarbamoyladenylate synthase
FY146_RS02145	COG4638	Rieske (2fe-2S)
FY146_RS02170	COG1960	acyl-CoA dehydrogenase activity
FY146_RS02185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY146_RS02190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY146_RS02195	COG0840	transmembrane signaling receptor activity
FY146_RS02205	COG1522	sequence-specific DNA binding
FY146_RS02230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY146_RS02235	COG1741	Belongs to the pirin family
FY146_RS02240	COG1722	exodeoxyribonuclease VII activity
FY146_RS02245	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY146_RS02250	COG1268	BioY protein
FY146_RS02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY146_RS02260	COG1122	ATPase activity
FY146_RS02265	COG3214	Protein conserved in bacteria
FY146_RS02270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_RS02270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_RS02275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY146_RS02295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY146_RS02310	COG0259	pyridoxamine-phosphate oxidase activity
FY146_RS02340	COG0312	modulator of DNA gyrase
FY146_RS02355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_RS02360	COG0109	protoheme IX farnesyltransferase activity
FY146_RS02370	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY146_RS02385	COG3346	SURF1 family
FY146_RS02390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY146_RS02395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY146_RS02400	COG0328	RNA-DNA hybrid ribonuclease activity
FY146_RS02410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY146_RS02410	COG0678	peroxiredoxin activity
FY146_RS02420	COG1678	Uncharacterized ACR, COG1678
FY146_RS02425	COG3237	CsbD-like
FY146_RS02435	COG3300	MHYT domain
FY146_RS02435	COG5001	Diguanylate cyclase
FY146_RS02440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY146_RS02445	COG0612	Peptidase, M16
FY146_RS02470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY146_RS02475	COG1802	Transcriptional regulator
FY146_RS02490	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY146_RS02495	COG3609	addiction module antidote protein, CC2985 family
FY146_RS02500	COG3668	Plasmid stabilization system
FY146_RS02510	COG1194	a g-specific adenine glycosylase
FY146_RS02525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY146_RS02530	COG1196	nuclear chromosome segregation
FY146_RS02535	COG2514	catechol 2,3-dioxygenase activity
FY146_RS02540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY146_RS02540	COG0574	Belongs to the PEP-utilizing enzyme family
FY146_RS02550	COG1823	symporter activity
FY146_RS02575	COG0579	oxidoreductase
FY146_RS02590	COG2895	sulfate adenylyltransferase (ATP) activity
FY146_RS02595	COG0175	sulfate reduction
FY146_RS02600	COG0175	sulfate reduction
FY146_RS02605	COG1959	2 iron, 2 sulfur cluster binding
FY146_RS02610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY146_RS02615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_RS02620	COG4208	sulfate ABC transporter
FY146_RS02625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_RS02635	COG2199	diguanylate cyclase activity
FY146_RS02635	COG2200	EAL domain
FY146_RS02635	COG2203	Gaf domain
FY146_RS02645	COG1309	transcriptional regulator
FY146_RS02650	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS02655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY146_RS02685	COG0625	glutathione transferase activity
FY146_RS02695	COG0477	Major facilitator Superfamily
FY146_RS02705	COG3657	addiction module killer protein
FY146_RS02715	COG1793	dna ligase
FY146_RS02735	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS02740	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS02745	COG1846	Transcriptional regulator
FY146_RS02750	COG1764	response to oxidative stress
FY146_RS02765	COG0488	(ABC) transporter
FY146_RS02800	COG4221	oxidoreductase activity
FY146_RS02815	COG0433	COG0433 Predicted ATPase
FY146_RS02825	COG1733	regulation of RNA biosynthetic process
FY146_RS02830	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY146_RS02845	COG0656	L-ascorbic acid biosynthetic process
FY146_RS02850	COG3781	membrane
FY146_RS02855	COG2378	regulation of single-species biofilm formation
FY146_RS02865	COG4106	trans-aconitate 2-methyltransferase activity
FY146_RS02870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_RS02875	COG0840	transmembrane signaling receptor activity
FY146_RS02880	COG0583	DNA-binding transcription factor activity
FY146_RS02895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY146_RS02915	COG3909	cytochrome
FY146_RS02920	COG2010	Cytochrome c
FY146_RS02955	COG0789	Transcriptional regulator
FY146_RS02980	COG4175	Glycine betaine
FY146_RS02980	COG0517	IMP dehydrogenase activity
FY146_RS02985	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_RS03010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS03020	COG2169	Transcriptional regulator
FY146_RS03020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_RS03030	COG2514	catechol 2,3-dioxygenase activity
FY146_RS03050	COG1272	protein, Hemolysin III
FY146_RS03060	COG1280	lysine exporter protein (LysE YggA)
FY146_RS03065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY146_RS03070	COG2111	Na H antiporter
FY146_RS03070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY146_RS03075	COG2111	Na H antiporter
FY146_RS03080	COG1006	Multisubunit Na H antiporter MnhC subunit
FY146_RS03085	COG0651	ATP synthesis coupled electron transport
FY146_RS03090	COG1863	multisubunit Na H antiporter MnhE subunit
FY146_RS03095	COG2212	antiporter activity
FY146_RS03100	COG1320	monovalent cation:proton antiporter activity
FY146_RS03105	COG4957	zinc ion binding
FY146_RS03120	COG2166	iron-sulfur cluster assembly
FY146_RS03130	COG2205	protein histidine kinase activity
FY146_RS03175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_RS03180	COG2983	Belongs to the UPF0260 family
FY146_RS03195	COG2217	Heavy metal translocating P-type atpase
FY146_RS03225	COG2814	Major facilitator Superfamily
FY146_RS03235	COG1621	beta-fructofuranosidase activity
FY146_RS03240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY146_RS03290	COG4695	Portal protein
FY146_RS03395	COG4235	cytochrome complex assembly
FY146_RS03400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY146_RS03405	COG1138	Cytochrome C-type biogenesis protein
FY146_RS03410	COG3088	subunit of a heme lyase
FY146_RS03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_RS03420	COG0745	RESPONSE REGULATOR receiver
FY146_RS03425	COG2205	protein histidine kinase activity
FY146_RS03430	COG3011	Protein conserved in bacteria
FY146_RS03435	COG3713	MltA-interacting MipA family protein
FY146_RS03440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY146_RS03445	COG2202	Pas domain
FY146_RS03445	COG2205	protein histidine kinase activity
FY146_RS03455	COG0308	aminopeptidase N
FY146_RS03460	COG0697	spore germination
FY146_RS03475	COG0443	Heat shock 70 kDa protein
FY146_RS03510	COG0604	alcohol dehydrogenase
FY146_RS03515	COG1733	regulation of RNA biosynthetic process
FY146_RS03520	COG1968	undecaprenyl-diphosphatase activity
FY146_RS03525	COG2239	Acts as a magnesium transporter
FY146_RS03530	COG2814	Major facilitator Superfamily
FY146_RS03555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY146_RS03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY146_RS03630	COG0741	lytic transglycosylase activity
FY146_RS03635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS03640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY146_RS03645	COG0840	transmembrane signaling receptor activity
FY146_RS03655	COG1758	RNA polymerase activity
FY146_RS03675	COG0736	holo-[acyl-carrier-protein] synthase activity
FY146_RS03680	COG0681	Belongs to the peptidase S26 family
FY146_RS03685	COG0571	ribonuclease III activity
FY146_RS03690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY146_RS03700	COG0784	Response regulator, receiver
FY146_RS03705	COG1381	Involved in DNA repair and RecF pathway recombination
FY146_RS03715	COG2226	methyltransferase
FY146_RS03725	COG1418	mRNA catabolic process
FY146_RS03735	COG0346	lactoylglutathione lyase activity
FY146_RS03750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS03755	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY146_RS03760	COG0668	transmembrane transport
FY146_RS03770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY146_RS03800	COG1742	UPF0060 membrane protein
FY146_RS03820	COG1183	phosphatidylcholine synthase activity
FY146_RS03825	COG0688	phosphatidylethanolamine metabolic process
FY146_RS03830	COG5265	(ABC) transporter
FY146_RS03870	COG2852	Protein conserved in bacteria
FY146_RS03875	COG0215	cysteine-tRNA ligase activity
FY146_RS03880	COG4221	oxidoreductase activity
FY146_RS03885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY146_RS03890	COG1286	toxin biosynthetic process
FY146_RS03905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY146_RS03915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY146_RS03925	COG0305	Participates in initiation and elongation during chromosome replication
FY146_RS03945	COG0359	binds to the 23S rRNA
FY146_RS03955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY146_RS03960	COG0360	Binds together with S18 to 16S ribosomal RNA
FY146_RS03970	COG0667	Aldo Keto reductase
FY146_RS03975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY146_RS03985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_RS03990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_RS04000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY146_RS04005	COG1561	YicC-like family, N-terminal region
FY146_RS04010	COG0194	GDP metabolic process
FY146_RS04025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY146_RS04030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_RS04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY146_RS04055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY146_RS04075	COG4251	negative regulation of phosphorylation
FY146_RS04075	COG5001	Diguanylate cyclase
FY146_RS04075	COG3706	GGDEF domain
FY146_RS04075	COG2203	Gaf domain
FY146_RS04080	COG3300	MHYT domain
FY146_RS04080	COG5001	Diguanylate cyclase
FY146_RS04085	COG4191	Histidine kinase
FY146_RS04090	COG4566	intracellular signal transduction
FY146_RS04100	COG0488	(ABC) transporter
FY146_RS04105	COG3706	GGDEF domain
FY146_RS04115	COG0105	UTP biosynthetic process
FY146_RS04135	COG0314	molybdopterin synthase activity
FY146_RS04145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY146_RS04150	COG0322	excinuclease ABC activity
FY146_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS04180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY146_RS04185	COG0243	molybdopterin cofactor binding
FY146_RS04200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY146_RS04205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY146_RS04210	COG2226	methyltransferase
FY146_RS04215	COG0628	permease
FY146_RS04225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY146_RS04230	COG0248	Ppx GppA phosphatase
FY146_RS04255	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY146_RS04265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY146_RS04270	COG0477	Major facilitator Superfamily
FY146_RS04275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY146_RS04285	COG0840	transmembrane signaling receptor activity
FY146_RS04290	COG0659	secondary active sulfate transmembrane transporter activity
FY146_RS04300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY146_RS04305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY146_RS04315	COG0113	porphobilinogen synthase activity
FY146_RS04335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY146_RS04340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY146_RS04345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY146_RS04345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY146_RS04355	COG1280	lysine exporter protein (LysE YggA)
FY146_RS04360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY146_RS04365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY146_RS04370	COG2814	Major facilitator Superfamily
FY146_RS04375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY146_RS04395	COG0416	fatty acid biosynthetic process
FY146_RS04400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY146_RS04405	COG0776	regulation of translation
FY146_RS04440	COG0601	transmembrane transport
FY146_RS04445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS04450	COG0444	Belongs to the ABC transporter superfamily
FY146_RS04460	COG0747	negative chemotaxis
FY146_RS04470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY146_RS04475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY146_RS04490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY146_RS04495	COG0583	DNA-binding transcription factor activity
FY146_RS04500	COG0737	Belongs to the 5'-nucleotidase family
FY146_RS04520	COG2897	thiosulfate sulfurtransferase activity
FY146_RS04535	COG0415	Belongs to the DNA photolyase family
FY146_RS04545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_RS04575	COG3932	Exopolysaccharide synthesis, ExoD
FY146_RS04580	COG1238	metal cluster binding
FY146_RS04655	COG1612	heme a metabolic process
FY146_RS04665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY146_RS04670	COG0010	Belongs to the arginase family
FY146_RS04675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY146_RS04680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY146_RS04690	COG1832	CoA-binding protein
FY146_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS04720	COG2124	cytochrome p450
FY146_RS04725	COG2199	diguanylate cyclase activity
FY146_RS04730	COG0740	serine-type endopeptidase activity
FY146_RS04735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY146_RS04740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY146_RS04750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_RS04780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_RS04785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_RS04790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_RS04800	COG0649	NAD binding
FY146_RS04810	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY146_RS04815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY146_RS04825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY146_RS04830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_RS04840	COG0713	ATP synthesis coupled electron transport
FY146_RS04855	COG1007	ATP synthesis coupled electron transport
FY146_RS04860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY146_RS04860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY146_RS04875	COG0442	prolyl-tRNA aminoacylation
FY146_RS04885	COG1136	(ABC) transporter
FY146_RS04900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY146_RS04920	COG0784	Response regulator, receiver
FY146_RS04930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY146_RS04935	COG0477	Major facilitator Superfamily
FY146_RS04950	COG0557	exoribonuclease II activity
FY146_RS04955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY146_RS04965	COG0758	DNA mediated transformation
FY146_RS04970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY146_RS04980	COG0540	Belongs to the ATCase OTCase family
FY146_RS04995	COG1960	acyl-CoA dehydrogenase activity
FY146_RS05000	COG0456	acetyltransferase
FY146_RS05020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY146_RS05025	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_RS05030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY146_RS05035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY146_RS05040	COG0154	amidase activity
FY146_RS05045	COG0456	acetyltransferase
FY146_RS05050	COG3811	Belongs to the UPF0386 family
FY146_RS05065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY146_RS05095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY146_RS05100	COG0439	Biotin carboxylase
FY146_RS05105	COG0511	ligase activity, forming carbon-carbon bonds
FY146_RS05110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY146_RS05120	COG0436	Aminotransferase
FY146_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS05145	COG1530	ribonuclease E activity
FY146_RS05155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_RS05175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY146_RS05180	COG0384	phenazine biosynthesis protein PhzF
FY146_RS05200	COG0633	Ferredoxin
FY146_RS05210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY146_RS05215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY146_RS05220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY146_RS05230	COG3768	UPF0283 membrane protein
FY146_RS05235	COG3106	COG3106 Predicted ATPase
FY146_RS05265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY146_RS05300	COG0537	adenosine 5'-monophosphoramidase activity
FY146_RS05330	COG0052	Belongs to the universal ribosomal protein uS2 family
FY146_RS05335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY146_RS05340	COG0528	UMP kinase activity
FY146_RS05345	COG0233	cytoplasmic translational termination
FY146_RS05350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY146_RS05360	COG0750	zinc metalloprotease
FY146_RS05365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY146_RS05370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_RS05375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_RS05380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_RS05385	COG3494	Protein of unknown function (DUF1009)
FY146_RS05390	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_RS05395	COG2186	Transcriptional regulator
FY146_RS05405	COG0765	amino acid transport
FY146_RS05410	COG0765	amino acid transport
FY146_RS05420	COG0372	Belongs to the citrate synthase family
FY146_RS05435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY146_RS05460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FY146_RS05465	COG1459	type II secretion system
FY146_RS05520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY146_RS05525	COG0148	phosphopyruvate hydratase activity
FY146_RS05535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY146_RS05540	COG0022	dehydrogenase e1 component
FY146_RS05540	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_RS05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY146_RS05565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY146_RS05570	COG0697	spore germination
FY146_RS05590	COG2867	negative regulation of translational initiation
FY146_RS05595	COG1546	Belongs to the CinA family
FY146_RS05600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY146_RS05600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY146_RS05610	COG3852	Histidine kinase
FY146_RS05615	COG2204	response regulator
FY146_RS05620	COG5000	phosphorelay sensor kinase activity
FY146_RS05625	COG2204	response regulator
FY146_RS05635	COG1923	regulation of RNA biosynthetic process
FY146_RS05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY146_RS05645	COG3956	TIGRFAM MazG family protein
FY146_RS05655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY146_RS05655	COG1648	precorrin-2 dehydrogenase activity
FY146_RS05695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY146_RS05695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY146_RS05700	COG0509	glycine decarboxylation via glycine cleavage system
FY146_RS05705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_RS05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY146_RS05735	COG0564	pseudouridine synthase activity
FY146_RS05755	COG0251	oxidation-reduction process
FY146_RS05760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY146_RS05770	COG1671	Belongs to the UPF0178 family
FY146_RS05785	COG0450	alkyl hydroperoxide reductase
FY146_RS05790	COG0625	glutathione transferase activity
FY146_RS05810	COG0431	NADPH-dependent FMN reductase
FY146_RS05820	COG0798	PFAM Bile acid sodium symporter
FY146_RS05825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY146_RS05840	COG0321	lipoyl(octanoyl) transferase activity
FY146_RS05840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY146_RS05845	COG0084	hydrolase, TatD family'
FY146_RS05850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_RS05860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY146_RS05915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY146_RS05920	COG2095	MarC family integral membrane protein
FY146_RS05925	COG0517	IMP dehydrogenase activity
FY146_RS05925	COG0617	tRNA 3'-terminal CCA addition
FY146_RS05925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY146_RS05935	COG0629	single-stranded DNA binding
FY146_RS05940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY146_RS05950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY146_RS05970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_RS05975	COG1121	(ABC) transporter
FY146_RS05995	COG0667	Aldo Keto reductase
FY146_RS06005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY146_RS06085	COG2239	Acts as a magnesium transporter
FY146_RS06090	COG0243	molybdopterin cofactor binding
FY146_RS06100	COG0242	peptide deformylase activity
FY146_RS06115	COG2205	protein histidine kinase activity
FY146_RS06115	COG2202	Pas domain
FY146_RS06125	COG0321	lipoyl(octanoyl) transferase activity
FY146_RS06130	COG1064	alcohol dehydrogenase
FY146_RS06160	COG1862	Preprotein translocase
FY146_RS06180	COG2124	cytochrome p450
FY146_RS06195	COG0596	Alpha beta hydrolase
FY146_RS06205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_RS06210	COG0626	cystathionine gamma-synthase activity
FY146_RS06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS06220	COG4597	amino acid ABC transporter
FY146_RS06225	COG0765	amino acid transport
FY146_RS06230	COG1126	abc transporter atp-binding protein
FY146_RS06245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY146_RS06260	COG0436	Aminotransferase
FY146_RS06290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_RS06300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_RS06305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_RS06310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY146_RS06325	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY146_RS06330	COG1489	DNA binding
FY146_RS06335	COG0024	Methionine aminopeptidase
FY146_RS06340	COG2003	Belongs to the UPF0758 family
FY146_RS06355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY146_RS06380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY146_RS06385	COG0546	phosphoglycolate phosphatase activity
FY146_RS06395	COG0114	fumarate hydratase activity
FY146_RS06405	COG0504	CTP synthase activity
FY146_RS06415	COG0149	triose-phosphate isomerase activity
FY146_RS06425	COG0187	DNA topoisomerase II activity
FY146_RS06435	COG0740	serine-type endopeptidase activity
FY146_RS06445	COG0640	Transcriptional regulator
FY146_RS06450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_RS06455	COG0745	RESPONSE REGULATOR receiver
FY146_RS06470	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY146_RS06470	COG3264	Mechanosensitive ion channel
FY146_RS06535	COG1127	ABC transporter
FY146_RS06540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY146_RS06545	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS06555	COG0280	phosphate acetyltransferase
FY146_RS06555	COG0281	malic enzyme
FY146_RS06565	COG0778	Nitroreductase
FY146_RS06570	COG0823	Involved in the tonB-independent uptake of proteins
FY146_RS06585	COG1368	sulfuric ester hydrolase activity
FY146_RS06610	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY146_RS06630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY146_RS06655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY146_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
FY146_RS06680	COG0512	Glutamine amidotransferase of anthranilate synthase
FY146_RS06680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY146_RS06685	COG0343	queuine tRNA-ribosyltransferase activity
FY146_RS06690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY146_RS06705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY146_RS06725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_RS06730	COG0134	indole-3-glycerol-phosphate synthase activity
FY146_RS06735	COG0315	cyclic pyranopterin monophosphate synthase activity
FY146_RS06740	COG0303	'Molybdopterin
FY146_RS06745	COG3706	GGDEF domain
FY146_RS06755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY146_RS06755	COG0475	glutathione-regulated potassium exporter activity
FY146_RS06765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY146_RS06775	COG2814	Major facilitator Superfamily
FY146_RS06780	COG0746	molybdenum cofactor guanylyltransferase activity
FY146_RS06785	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY146_RS06790	COG0739	heme binding
FY146_RS06795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY146_RS06800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY146_RS06805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY146_RS06810	COG0805	protein transport
FY146_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY146_RS06820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY146_RS06825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY146_RS06830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY146_RS06835	COG1472	Belongs to the glycosyl hydrolase 3 family
FY146_RS06845	COG0018	arginyl-trna synthetase
FY146_RS06850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY146_RS06875	COG0525	valine-tRNA ligase activity
FY146_RS06885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY146_RS07025	COG1525	nuclease
FY146_RS07100	COG3567	Phage-associated protein, HI1409 family
FY146_RS07150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY146_RS07175	COG1372	Participates in initiation and elongation during chromosome replication
FY146_RS07175	COG0305	Participates in initiation and elongation during chromosome replication
FY146_RS07340	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY146_RS07345	COG1058	Belongs to the CinA family
FY146_RS07345	COG1546	Belongs to the CinA family
FY146_RS07350	COG0589	response to stress
FY146_RS07355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY146_RS07370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY146_RS07380	COG0640	Transcriptional regulator
FY146_RS07385	COG1914	H( )-stimulated, divalent metal cation uptake system
FY146_RS07395	COG1132	(ABC) transporter
FY146_RS07400	COG0628	permease
FY146_RS07435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY146_RS07445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY146_RS07455	COG0302	gtp cyclohydrolase
FY146_RS07460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY146_RS07465	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_RS07475	COG0516	GMP reductase activity
FY146_RS07475	COG0517	IMP dehydrogenase activity
FY146_RS07510	COG1760	l-serine dehydratase
FY146_RS07550	COG0583	DNA-binding transcription factor activity
FY146_RS07565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY146_RS07565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY146_RS07575	COG0347	Belongs to the P(II) protein family
FY146_RS07580	COG0174	glutamine synthetase
FY146_RS07610	COG0697	spore germination
FY146_RS07620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY146_RS07630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY146_RS07660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY146_RS07670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY146_RS07675	COG2186	Transcriptional regulator
FY146_RS07685	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_RS07690	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY146_RS07695	COG3845	ABC transporter
FY146_RS07700	COG1183	phosphatidylcholine synthase activity
FY146_RS07705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_RS07710	COG0679	Auxin Efflux Carrier
FY146_RS07715	COG0785	Cytochrome C biogenesis protein
FY146_RS07735	COG1278	Cold shock
FY146_RS07790	COG0577	efflux transmembrane transporter activity
FY146_RS07790	COG1136	(ABC) transporter
FY146_RS07795	COG0577	efflux transmembrane transporter activity
FY146_RS07795	COG1136	(ABC) transporter
FY146_RS07820	COG2151	metal-sulfur cluster biosynthetic enzyme
FY146_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY146_RS07830	COG0719	Fe-S assembly protein
FY146_RS07835	COG0396	ATPase activity
FY146_RS07840	COG0719	Fe-S assembly protein
FY146_RS07845	COG1104	cysteine desulfurase activity
FY146_RS07850	COG2945	thiolester hydrolase activity
FY146_RS07855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY146_RS07860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY146_RS07870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY146_RS07875	COG2833	Protein of unknown function (DUF455)
FY146_RS07880	COG0739	heme binding
FY146_RS07885	COG0513	Belongs to the DEAD box helicase family
FY146_RS07910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY146_RS07920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY146_RS07925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY146_RS07930	COG0047	phosphoribosylformylglycinamidine synthase activity
FY146_RS07945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_RS07950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY146_RS07970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY146_RS07975	COG2814	Major facilitator Superfamily
FY146_RS07980	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS07985	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS07990	COG0037	tRNA processing
FY146_RS07995	COG2066	Belongs to the glutaminase family
FY146_RS08000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY146_RS08005	COG0861	Integral membrane protein TerC family
FY146_RS08020	COG1280	lysine exporter protein (LysE YggA)
FY146_RS08030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY146_RS08035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY146_RS08045	COG0538	isocitrate dehydrogenase activity
FY146_RS08055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY146_RS08060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY146_RS08065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS08070	COG2313	pseudouridylate synthase activity
FY146_RS08080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS08085	COG4215	(ABC) transporter
FY146_RS08095	COG5425	PFAM Usg family protein
FY146_RS08105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS08110	COG1522	sequence-specific DNA binding
FY146_RS08115	COG1573	uracil-dna glycosylase
FY146_RS08125	COG2202	Pas domain
FY146_RS08125	COG2205	protein histidine kinase activity
FY146_RS08130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY146_RS08135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY146_RS08140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY146_RS08155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_RS08160	COG0842	Transport permease protein
FY146_RS08165	COG1131	(ABC) transporter
FY146_RS08170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_RS08170	COG0730	response to heat
FY146_RS08190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY146_RS08195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_RS08215	COG0129	dihydroxy-acid dehydratase activity
FY146_RS08220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY146_RS08225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY146_RS08235	COG3739	integral membrane protein
FY146_RS08240	COG0203	ribosomal protein L17
FY146_RS08245	COG0202	RNA polymerase activity
FY146_RS08250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY146_RS08255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY146_RS08260	COG0563	adenylate kinase activity
FY146_RS08265	COG0201	protein transport
FY146_RS08270	COG0200	Binds to the 23S rRNA
FY146_RS08275	COG1841	ribosomal large subunit assembly
FY146_RS08280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY146_RS08285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY146_RS08290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY146_RS08295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY146_RS08300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY146_RS08305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY146_RS08310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY146_RS08315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY146_RS08320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY146_RS08325	COG0255	Belongs to the universal ribosomal protein uL29 family
FY146_RS08330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY146_RS08335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY146_RS08340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY146_RS08345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY146_RS08350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY146_RS08355	COG0089	rRNA binding
FY146_RS08360	COG0088	Forms part of the polypeptide exit tunnel
FY146_RS08365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY146_RS08370	COG0051	transcription antitermination factor activity, RNA binding
FY146_RS08375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY146_RS08380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY146_RS08385	COG0049	tRNA binding
FY146_RS08390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY146_RS08410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY146_RS08415	COG0085	RNA polymerase activity
FY146_RS08420	COG0222	ribosome binding
FY146_RS08425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY146_RS08430	COG0081	regulation of translation
FY146_RS08435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY146_RS08445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY146_RS08455	COG1086	Polysaccharide biosynthesis protein
FY146_RS08460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY146_RS08465	COG0861	Integral membrane protein TerC family
FY146_RS08470	COG3895	Periplasmic Protein
FY146_RS08490	COG1132	(ABC) transporter
FY146_RS08495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_RS08515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_RS08550	COG2205	protein histidine kinase activity
FY146_RS08550	COG2198	Histidine kinase
FY146_RS08550	COG0784	Response regulator, receiver
FY146_RS08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS08555	COG0784	Response regulator, receiver
FY146_RS08560	COG2202	Pas domain
FY146_RS08560	COG3920	Histidine kinase
FY146_RS08565	COG0784	Response regulator, receiver
FY146_RS08570	COG4251	negative regulation of phosphorylation
FY146_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY146_RS08590	COG1607	acyl-coa hydrolase
FY146_RS08610	COG2910	NAD(P)H-binding
FY146_RS08615	COG1733	regulation of RNA biosynthetic process
FY146_RS08630	COG0556	nucleotide-excision repair
FY146_RS08640	COG2382	esterase
FY146_RS08660	COG0484	heat shock protein binding
FY146_RS08680	COG3706	GGDEF domain
FY146_RS08700	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_RS08705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_RS08720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY146_RS08730	COG2207	Transcriptional regulator
FY146_RS08735	COG1064	alcohol dehydrogenase
FY146_RS08740	COG1252	NADH dehydrogenase
FY146_RS08745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY146_RS08750	COG2197	response regulator
FY146_RS08755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY146_RS08790	COG0656	L-ascorbic acid biosynthetic process
FY146_RS08805	COG0440	acetolactate synthase activity
FY146_RS08810	COG0028	Belongs to the TPP enzyme family
FY146_RS08820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY146_RS08825	COG0560	Phosphoserine phosphatase
FY146_RS08825	COG3830	Belongs to the UPF0237 family
FY146_RS08845	COG0330	HflC and HflK could
FY146_RS08850	COG0330	HflC and HflK could
FY146_RS08860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY146_RS08895	COG0277	FAD linked oxidase domain protein
FY146_RS08900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_RS08940	COG1335	isochorismatase
FY146_RS08970	COG2264	protein methyltransferase activity
FY146_RS08975	COG1999	signal sequence binding
FY146_RS08985	COG0835	chemotaxis
FY146_RS08995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY146_RS09000	COG0583	DNA-binding transcription factor activity
FY146_RS09010	COG1247	-acetyltransferase
FY146_RS09020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY146_RS09025	COG0497	DNA recombination
FY146_RS09030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY146_RS09040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_RS09045	COG0849	cell division
FY146_RS09050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY146_RS09055	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY146_RS09060	COG0477	Major facilitator Superfamily
FY146_RS09065	COG5001	Diguanylate cyclase
FY146_RS09070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY146_RS09075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY146_RS09080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY146_RS09090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY146_RS09095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY146_RS09105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY146_RS09120	COG0275	rRNA processing
FY146_RS09125	COG2001	Belongs to the MraZ family
FY146_RS09150	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY146_RS09180	COG4106	trans-aconitate 2-methyltransferase activity
FY146_RS09200	COG2226	methyltransferase
FY146_RS09210	COG2267	carboxylic ester hydrolase activity
FY146_RS09215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY146_RS09230	COG0251	oxidation-reduction process
FY146_RS09245	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS09250	COG2814	Major facilitator Superfamily
FY146_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS09285	COG0174	glutamine synthetase
FY146_RS09290	COG0531	amino acid
FY146_RS09300	COG1737	Transcriptional regulator
FY146_RS09305	COG2182	Extracellular solute-binding protein
FY146_RS09320	COG3842	ATPase activity
FY146_RS09380	COG2968	Membrane
FY146_RS09390	COG0432	Pfam Uncharacterised protein family UPF0047
FY146_RS09405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY146_RS09410	COG0358	DNA primase activity
FY146_RS09430	COG0505	Belongs to the CarA family
FY146_RS09435	COG0534	Mate efflux family protein
FY146_RS09450	COG2321	neutral zinc metallopeptidase
FY146_RS09465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY146_RS09475	COG3706	GGDEF domain
FY146_RS09490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY146_RS09500	COG1522	sequence-specific DNA binding
FY146_RS09505	COG0492	ferredoxin-NADP+ reductase activity
FY146_RS09510	COG0583	DNA-binding transcription factor activity
FY146_RS09520	COG1902	pentaerythritol trinitrate reductase activity
FY146_RS09545	COG0387	Pfam Sodium calcium exchanger
FY146_RS09550	COG0436	Aminotransferase
FY146_RS09555	COG2200	EAL domain
FY146_RS09555	COG2199	diguanylate cyclase activity
FY146_RS09570	COG1278	Cold shock
FY146_RS09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_RS09585	COG1846	Transcriptional regulator
FY146_RS09590	COG0745	RESPONSE REGULATOR receiver
FY146_RS09600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_RS09620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY146_RS09630	COG1496	oxidoreductase activity
FY146_RS09645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY146_RS09655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FY146_RS09670	COG0840	transmembrane signaling receptor activity
FY146_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS09680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY146_RS09685	COG5001	Diguanylate cyclase
FY146_RS09685	COG3300	MHYT domain
FY146_RS09690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY146_RS09695	COG5001	Diguanylate cyclase
FY146_RS09705	COG0193	aminoacyl-tRNA hydrolase activity
FY146_RS09715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY146_RS09740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY146_RS09750	COG2857	Cytochrome c1
FY146_RS09750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY146_RS09770	COG1132	(ABC) transporter
FY146_RS09780	COG1132	(ABC) transporter
FY146_RS09790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY146_RS09805	COG0408	coproporphyrinogen oxidase activity
FY146_RS09820	COG0617	tRNA 3'-terminal CCA addition
FY146_RS09835	COG0714	Associated with various cellular activities
FY146_RS09855	COG0454	-acetyltransferase
FY146_RS09870	COG0477	Major facilitator Superfamily
FY146_RS09880	COG0435	Glutathione S-transferase
FY146_RS09885	COG0494	nUDIX hydrolase
FY146_RS09895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY146_RS09900	COG3135	benzoate transporter
FY146_RS09925	COG0740	serine-type endopeptidase activity
FY146_RS09940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY146_RS09945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY146_RS09970	COG4175	Glycine betaine
FY146_RS09990	COG1435	thymidine kinase activity
FY146_RS10015	COG4771	TonB-dependent receptor
FY146_RS10015	COG1629	transport
FY146_RS10025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY146_RS10025	COG0512	Glutamine amidotransferase of anthranilate synthase
FY146_RS10040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY146_RS10050	COG0366	Alpha amylase catalytic
FY146_RS10055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS10075	COG1160	GTP binding
FY146_RS10095	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY146_RS10105	COG0024	Methionine aminopeptidase
FY146_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS10135	COG0583	DNA-binding transcription factor activity
FY146_RS10150	COG0402	S-adenosylhomocysteine deaminase activity
FY146_RS10160	COG1304	FMN binding
FY146_RS10170	COG1309	transcriptional regulator
FY146_RS10175	COG1686	Belongs to the peptidase S11 family
FY146_RS10185	COG2351	hydroxyisourate hydrolase activity
FY146_RS10190	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY146_RS10215	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_RS10225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY146_RS10225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS10235	COG0513	Belongs to the DEAD box helicase family
FY146_RS10245	COG2259	Doxx family
FY146_RS10250	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS10260	COG2308	Evidence 4 Homologs of previously reported genes of
FY146_RS10270	COG1305	Transglutaminase-like
FY146_RS10295	COG4214	carbohydrate transport
FY146_RS10305	COG4213	ABC transporter substrate-binding protein
FY146_RS10360	COG2948	multi-organism process
FY146_RS10370	COG3701	Conjugal transfer protein
FY146_RS10375	COG3846	protein secretion by the type IV secretion system
FY146_RS10390	COG3451	type IV secretory pathway VirB4
FY146_RS10405	COG4962	Type ii secretion system protein e
FY146_RS10430	COG0583	DNA-binding transcription factor activity
FY146_RS10440	COG1566	PFAM secretion protein HlyD family protein
FY146_RS10455	COG2207	Transcriptional regulator
FY146_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS10470	COG0583	DNA-binding transcription factor activity
FY146_RS10480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY146_RS10495	COG0583	DNA-binding transcription factor activity
FY146_RS10530	COG1192	Involved in chromosome partitioning
FY146_RS10570	COG2814	Major facilitator Superfamily
FY146_RS10580	COG5489	Protein of unknown function (DUF736)
FY146_RS10595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY146_RS10625	COG1204	response to ionizing radiation
FY146_RS10640	COG0514	ATP-dependent DNA helicase (RecQ)
FY146_RS10690	COG0583	DNA-binding transcription factor activity
FY146_RS10695	COG1902	pentaerythritol trinitrate reductase activity
FY146_RS10700	COG0583	DNA-binding transcription factor activity
FY146_RS10715	COG1335	isochorismatase
FY146_RS10720	COG0583	DNA-binding transcription factor activity
FY146_RS10725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_RS10735	COG4584	PFAM Integrase catalytic
FY146_RS10750	COG0840	transmembrane signaling receptor activity
FY146_RS10765	COG0646	methionine synthase
FY146_RS10765	COG1410	methionine synthase
FY146_RS10780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS10810	COG1215	transferase activity, transferring glycosyl groups
FY146_RS10840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY146_RS10855	COG2346	COG2346, Truncated hemoglobins
FY146_RS10875	COG1309	transcriptional regulator
FY146_RS10890	COG0494	nUDIX hydrolase
FY146_RS10900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS10905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS10935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY146_RS10940	COG0830	nickel cation binding
FY146_RS10945	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY146_RS10960	COG0804	urea catabolic process
FY146_RS10965	COG1442	glycosyl transferase family 8
FY146_RS10970	COG3755	Protein conserved in bacteria
FY146_RS10980	COG0832	Belongs to the urease beta subunit family
FY146_RS10985	COG3813	Protein conserved in bacteria
FY146_RS10990	COG0831	urea catabolic process
FY146_RS10995	COG0829	nickel cation binding
FY146_RS11025	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY146_RS11045	COG0174	glutamine synthetase
FY146_RS11050	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS11055	COG0784	Response regulator, receiver
FY146_RS11055	COG2198	Histidine kinase
FY146_RS11055	COG5002	protein histidine kinase activity
FY146_RS11070	COG0726	polysaccharide deacetylase
FY146_RS11105	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY146_RS11180	COG0564	pseudouridine synthase activity
FY146_RS11190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY146_RS11200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY146_RS11225	COG0346	lactoylglutathione lyase activity
FY146_RS11235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY146_RS11245	COG2832	Protein of unknown function (DUF454)
FY146_RS11250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY146_RS11255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS11260	COG4558	Periplasmic binding protein
FY146_RS11270	COG3721	Heme iron utilization protein
FY146_RS11285	COG3655	Transcriptional regulator
FY146_RS11310	COG2205	protein histidine kinase activity
FY146_RS11350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS11355	COG4605	iron ion homeostasis
FY146_RS11360	COG4604	ABC transporter, ATP-binding protein
FY146_RS11365	COG0783	Belongs to the Dps family
FY146_RS11380	COG0840	transmembrane signaling receptor activity
FY146_RS11380	COG2972	Histidine kinase
FY146_RS11385	COG0656	L-ascorbic acid biosynthetic process
FY146_RS11390	COG2814	Major facilitator Superfamily
FY146_RS11400	COG0583	DNA-binding transcription factor activity
FY146_RS11405	COG0657	acetylesterase activity
FY146_RS11410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS11430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_RS11435	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY146_RS11440	COG0288	reversible hydration of carbon dioxide
FY146_RS11450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY146_RS11470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY146_RS11475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_RS11480	COG0778	Nitroreductase
FY146_RS11485	COG2267	carboxylic ester hydrolase activity
FY146_RS11490	COG0251	oxidation-reduction process
FY146_RS11495	COG1335	isochorismatase
FY146_RS11500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS11510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS11525	COG1175	transmembrane transport
FY146_RS11530	COG0395	ABC-type sugar transport system, permease component
FY146_RS11535	COG3842	ATPase activity
FY146_RS11540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS11550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_RS11565	COG4608	Belongs to the ABC transporter superfamily
FY146_RS11570	COG0444	Belongs to the ABC transporter superfamily
FY146_RS11575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS11580	COG0601	transmembrane transport
FY146_RS11635	COG2159	amidohydrolase
FY146_RS11640	COG1960	acyl-CoA dehydrogenase activity
FY146_RS11670	COG0745	RESPONSE REGULATOR receiver
FY146_RS11680	COG1902	pentaerythritol trinitrate reductase activity
FY146_RS11680	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_RS11685	COG3842	ATPase activity
FY146_RS11695	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_RS11700	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_RS11705	COG0745	RESPONSE REGULATOR receiver
FY146_RS11715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY146_RS11720	COG0583	DNA-binding transcription factor activity
FY146_RS11725	COG1278	Cold shock
FY146_RS11765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY146_RS11770	COG1309	transcriptional regulator
FY146_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS11780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_RS11790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY146_RS11795	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY146_RS11815	COG0583	DNA-binding transcription factor activity
FY146_RS11820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS11825	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY146_RS11830	COG4149	molybdate abc transporter
FY146_RS11835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY146_RS11850	COG2022	thiamine diphosphate biosynthetic process
FY146_RS11865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY146_RS11870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_RS11880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY146_RS11900	COG1132	(ABC) transporter
FY146_RS11905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY146_RS11950	COG4166	transmembrane transport
FY146_RS11955	COG0601	transmembrane transport
FY146_RS11960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS11975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY146_RS11980	COG3142	Participates in the control of copper homeostasis
FY146_RS11985	COG2814	Major facilitator Superfamily
FY146_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS12005	COG1737	Transcriptional regulator
FY146_RS12015	COG3842	ATPase activity
FY146_RS12025	COG0395	ABC-type sugar transport system, permease component
FY146_RS12045	COG2188	Transcriptional regulator
FY146_RS12050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY146_RS12055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY146_RS12060	COG1940	carbohydrate kinase activity
FY146_RS12070	COG0671	phosphoesterase, PA-phosphatase related
FY146_RS12075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY146_RS12080	COG0156	8-amino-7-oxononanoate synthase activity
FY146_RS12090	COG0729	surface antigen
FY146_RS12100	COG0835	chemotaxis
FY146_RS12110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY146_RS12115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY146_RS12120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY146_RS12125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY146_RS12130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY146_RS12135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY146_RS12150	COG4974	Belongs to the 'phage' integrase family
FY146_RS12175	COG1280	lysine exporter protein (LysE YggA)
FY146_RS12185	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_RS12190	COG0567	Dehydrogenase, E1 component
FY146_RS12195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY146_RS12200	COG0045	succinate-CoA ligase (ADP-forming) activity
FY146_RS12205	COG0039	L-malate dehydrogenase activity
FY146_RS12210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY146_RS12260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY146_RS12265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY146_RS12270	COG0181	hydroxymethylbilane synthase activity
FY146_RS12310	COG1872	DUF167
FY146_RS12315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY146_RS12325	COG1217	gtp-binding protein TYPA
FY146_RS12330	COG0339	signal peptide processing
FY146_RS12335	COG1846	Transcriptional regulator
FY146_RS12345	COG0137	argininosuccinate synthase activity
FY146_RS12355	COG1280	lysine exporter protein (LysE YggA)
FY146_RS12360	COG1122	ATPase activity
FY146_RS12365	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY146_RS12375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY146_RS12390	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY146_RS12395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY146_RS12400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY146_RS12410	COG4181	ATPase activity
FY146_RS12420	COG0670	Belongs to the BI1 family
FY146_RS12435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY146_RS12440	COG4133	protoheme IX ABC transporter activity
FY146_RS12445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY146_RS12450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY146_RS12475	COG2917	probably involved in intracellular septation
FY146_RS12480	COG0552	protein localization to endoplasmic reticulum
FY146_RS12485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY146_RS12490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY146_RS12505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY146_RS12510	COG1605	Chorismate mutase
FY146_RS12510	COG0287	Prephenate dehydrogenase
FY146_RS12515	COG0228	four-way junction DNA binding
FY146_RS12520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY146_RS12525	COG0336	Belongs to the RNA methyltransferase TrmD family
FY146_RS12535	COG0335	large ribosomal subunit rRNA binding
FY146_RS12540	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY146_RS12545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS12560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY146_RS12580	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY146_RS12600	COG0488	(ABC) transporter
FY146_RS12610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY146_RS12620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY146_RS12625	COG0142	geranyltranstransferase activity
FY146_RS12630	COG2885	chlorophyll binding
FY146_RS12635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY146_RS12640	COG2223	nitrite transmembrane transporter activity
FY146_RS12645	COG1349	DNA-binding transcription factor activity
FY146_RS12650	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY146_RS12655	COG2197	response regulator
FY146_RS12660	COG1132	(ABC) transporter
FY146_RS12670	COG3459	Glycosyltransferase 36 associated
FY146_RS12675	COG1473	amidohydrolase
FY146_RS12685	COG0579	oxidoreductase
FY146_RS12695	COG0129	dihydroxy-acid dehydratase activity
FY146_RS12700	COG2084	Dehydrogenase
FY146_RS12705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS12710	COG0277	FAD linked oxidase domain protein
FY146_RS12715	COG2186	Transcriptional regulator
FY146_RS12725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_RS12730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_RS12735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_RS12740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY146_RS12750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY146_RS12755	COG0495	leucyl-tRNA aminoacylation
FY146_RS12770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY146_RS12775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY146_RS12790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_RS12795	COG1946	Acyl-CoA thioesterase
FY146_RS12800	COG0347	Belongs to the P(II) protein family
FY146_RS12805	COG0004	ammonium transporteR
FY146_RS12810	COG1674	ftsk spoiiie
FY146_RS12815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY146_RS12830	COG0745	RESPONSE REGULATOR receiver
FY146_RS12840	COG1329	Transcriptional regulator
FY146_RS12850	COG2270	Major facilitator Superfamily
FY146_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS12880	COG0494	nUDIX hydrolase
FY146_RS12885	COG2861	carbohydrate metabolic process
FY146_RS12890	COG0793	Belongs to the peptidase S41A family
FY146_RS12900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY146_RS12905	COG0799	negative regulation of ribosome biogenesis
FY146_RS12910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY146_RS12915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY146_RS12920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY146_RS12925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY146_RS12940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY146_RS12945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY146_RS12970	COG0066	3-isopropylmalate dehydratase activity
FY146_RS12975	COG0473	3-isopropylmalate dehydrogenase activity
FY146_RS12980	COG1858	cytochrome C peroxidase
FY146_RS12985	COG1797	cobyrinic acid a,c-diamide synthase activity
FY146_RS12995	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY146_RS13060	COG1492	cobalamin metabolic process
FY146_RS13075	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS13080	COG3254	rhamnose metabolic process
FY146_RS13085	COG0246	Mannitol dehydrogenase
FY146_RS13090	COG1063	alcohol dehydrogenase
FY146_RS13115	COG1129	ABC transporter
FY146_RS13120	COG2186	Transcriptional regulator
FY146_RS13125	COG2721	sulfolactate sulfo-lyase activity
FY146_RS13130	COG0138	bifunctional purine biosynthesis protein purh
FY146_RS13140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY146_RS13140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY146_RS13145	COG0501	Belongs to the peptidase M48B family
FY146_RS13165	COG0357	Ribosomal RNA small subunit methyltransferase G
FY146_RS13170	COG0445	tRNA wobble uridine modification
FY146_RS13175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY146_RS13180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY146_RS13185	COG1981	membrane
FY146_RS13190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY146_RS13195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY146_RS13200	COG0424	maF-like protein
FY146_RS13205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY146_RS13210	COG0237	dephospho-CoA kinase activity
FY146_RS13220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY146_RS13225	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY146_RS13235	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY146_RS13260	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY146_RS13275	COG0135	phosphoribosylanthranilate isomerase activity
FY146_RS13280	COG0133	tryptophan synthase activity
FY146_RS13285	COG0159	tryptophan synthase activity
FY146_RS13290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY146_RS13305	COG1074	ATP-dependent DNA helicase activity
FY146_RS13315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY146_RS13320	COG0802	atpase or kinase
FY146_RS13325	COG2205	protein histidine kinase activity
FY146_RS13330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY146_RS13335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_RS13340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY146_RS13340	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_RS13345	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY146_RS13350	COG0642	Histidine kinase
FY146_RS13355	COG0745	RESPONSE REGULATOR receiver
FY146_RS13360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY146_RS13370	COG1652	LysM domain
FY146_RS13375	COG1072	(Pantothenic acid kinase))
FY146_RS13380	COG0140	phosphoribosyl-ATP diphosphatase activity
FY146_RS13385	COG0107	imidazoleglycerol-phosphate synthase activity
FY146_RS13390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY146_RS13395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY146_RS13405	COG0131	Imidazoleglycerol-phosphate dehydratase
FY146_RS13410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY146_RS13415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY146_RS13425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY146_RS13440	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY146_RS13450	COG1643	Atp-dependent helicase
FY146_RS13495	COG1940	carbohydrate kinase activity
FY146_RS13515	COG1072	(Pantothenic acid kinase))
FY146_RS13525	COG1780	Probably involved in ribonucleotide reductase function
FY146_RS13545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY146_RS13575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS13585	COG2813	Specifically methylates the guanine in position
FY146_RS13590	COG1185	polyribonucleotide nucleotidyltransferase activity
FY146_RS13595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY146_RS13600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY146_RS13605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY146_RS13610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY146_RS13610	COG3064	Membrane
FY146_RS13625	COG0779	Required for maturation of 30S ribosomal subunits
FY146_RS13630	COG2814	Major facilitator Superfamily
FY146_RS13640	COG2951	lytic endotransglycosylase activity
FY146_RS13645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY146_RS13655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY146_RS13660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY146_RS13675	COG2816	NAD+ diphosphatase activity
FY146_RS13680	COG1605	Chorismate mutase
FY146_RS13680	COG0077	Prephenate dehydratase
FY146_RS13685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY146_RS13690	COG3474	cytochrome
FY146_RS13700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_RS13705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY146_RS13710	COG1278	Cold shock
FY146_RS13715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_RS13725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY146_RS13725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY146_RS13730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY146_RS13760	COG2900	Belongs to the SlyX family
FY146_RS13770	COG0484	heat shock protein binding
FY146_RS13775	COG0443	Heat shock 70 kDa protein
FY146_RS13790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY146_RS13795	COG1744	ABC transporter substrate-binding protein PnrA-like
FY146_RS13800	COG3845	ABC transporter
FY146_RS13805	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_RS13810	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_RS13815	COG0295	cytidine deaminase activity
FY146_RS13820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FY146_RS13825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY146_RS13830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY146_RS13840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY146_RS13845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY146_RS13850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY146_RS13860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY146_RS13865	COG1845	cytochrome c oxidase, subunit III
FY146_RS13870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_RS13875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY146_RS13880	COG0477	Major facilitator Superfamily
FY146_RS13885	COG0067	glutamate synthase
FY146_RS13885	COG0069	glutamate synthase activity
FY146_RS13885	COG0070	glutamate synthase
FY146_RS13890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY146_RS13905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY146_RS13915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_RS13945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS13965	COG0848	biopolymer transport protein
FY146_RS13975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_RS13990	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_RS13995	COG3454	Phosphonate metabolism
FY146_RS14000	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_RS14005	COG3639	organic phosphonate transmembrane transporter activity
FY146_RS14010	COG3639	organic phosphonate transmembrane transporter activity
FY146_RS14020	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY146_RS14030	COG4778	phosphonate C-P lyase system protein PhnL
FY146_RS14035	COG4107	phosphonate C-P lyase system protein PhnK
FY146_RS14040	COG3627	carbon phosphorus lyase activity
FY146_RS14045	COG3626	phosphonate metabolism
FY146_RS14050	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY146_RS14055	COG3624	Phosphonate C-P lyase system protein PhnG
FY146_RS14060	COG2188	Transcriptional regulator
FY146_RS14065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY146_RS14070	COG0837	glucose binding
FY146_RS14075	COG1803	Methylglyoxal synthase
FY146_RS14080	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY146_RS14085	COG4166	transmembrane transport
FY146_RS14090	COG4174	ABC transporter (Permease)
FY146_RS14095	COG4239	(ABC) transporter, permease
FY146_RS14100	COG4172	Belongs to the ABC transporter superfamily
FY146_RS14105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS14110	COG0174	glutamine synthetase
FY146_RS14115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS14120	COG3265	gluconokinase activity
FY146_RS14125	COG1174	glycine betaine transport
FY146_RS14130	COG1125	glycine betaine transport
FY146_RS14135	COG1174	glycine betaine transport
FY146_RS14140	COG1732	Glycine betaine
FY146_RS14150	COG1959	2 iron, 2 sulfur cluster binding
FY146_RS14155	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_RS14165	COG4269	membrane
FY146_RS14180	COG0697	spore germination
FY146_RS14195	COG0791	NLP P60 protein
FY146_RS14205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY146_RS14210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY146_RS14245	COG4964	Belongs to the GSP D family
FY146_RS14290	COG3422	double-strand break repair
FY146_RS14295	COG3757	hydrolase, family 25
FY146_RS14300	COG0697	spore germination
FY146_RS14305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_RS14320	COG0492	ferredoxin-NADP+ reductase activity
FY146_RS14335	COG0481	GTPase activity
FY146_RS14340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_RS14355	COG1396	sequence-specific DNA binding
FY146_RS14370	COG1917	Cupin 2, conserved barrel domain protein
FY146_RS14370	COG2169	Transcriptional regulator
FY146_RS14375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY146_RS14400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY146_RS14405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY146_RS14410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY146_RS14420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY146_RS14425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_RS14425	COG0072	phenylalanine-tRNA ligase activity
FY146_RS14430	COG0667	Aldo Keto reductase
FY146_RS14450	COG4977	sequence-specific DNA binding
FY146_RS14475	COG1570	exodeoxyribonuclease VII activity
FY146_RS14480	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS14490	COG1846	Transcriptional regulator
FY146_RS14500	COG2309	aminopeptidase activity
FY146_RS14510	COG1393	Belongs to the ArsC family
FY146_RS14530	COG1309	transcriptional regulator
FY146_RS14540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY146_RS14540	COG0519	Catalyzes the synthesis of GMP from XMP
FY146_RS14555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY146_RS14585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY146_RS14595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY146_RS14605	COG1968	undecaprenyl-diphosphatase activity
FY146_RS14620	COG0284	orotidine-5'-phosphate decarboxylase activity
FY146_RS14630	COG3963	phosphatidate phosphatase activity
FY146_RS14640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY146_RS14645	COG0792	nuclease activity
FY146_RS14660	COG1175	transmembrane transport
FY146_RS14665	COG0395	ABC-type sugar transport system, permease component
FY146_RS14670	COG3842	ATPase activity
FY146_RS14680	COG0189	ligase activity
FY146_RS14690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_RS14695	COG1280	lysine exporter protein (LysE YggA)
FY146_RS14700	COG0756	dUTP diphosphatase activity
FY146_RS14705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY146_RS14710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY146_RS14725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY146_RS14730	COG2226	methyltransferase
FY146_RS14735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY146_RS14740	COG1024	Enoyl-CoA hydratase
FY146_RS14745	COG0268	Binds directly to 16S ribosomal RNA
FY146_RS14750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY146_RS14765	COG0640	Transcriptional regulator
FY146_RS14800	COG4178	(ABC) transporter
FY146_RS14825	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS14830	COG0572	uridine kinase
FY146_RS14840	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS14845	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS14850	COG1129	ABC transporter
FY146_RS14870	COG3284	Transcriptional regulator
FY146_RS14875	COG1063	alcohol dehydrogenase
FY146_RS14885	COG0110	maltose O-acetyltransferase activity
FY146_RS14890	COG1049	propionate catabolic process, 2-methylcitrate cycle
FY146_RS14915	COG0488	(ABC) transporter
FY146_RS14920	COG5265	(ABC) transporter
FY146_RS14925	COG3181	Tripartite tricarboxylate transporter family receptor
FY146_RS14930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY146_RS14940	COG3237	CsbD-like
FY146_RS14960	COG0395	ABC-type sugar transport system, permease component
FY146_RS14965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_RS14975	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS14985	COG0405	Gamma-glutamyltransferase
FY146_RS14990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS14995	COG0601	transmembrane transport
FY146_RS15000	COG0747	negative chemotaxis
FY146_RS15005	COG2186	Transcriptional regulator
FY146_RS15015	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS15020	COG4172	Belongs to the ABC transporter superfamily
FY146_RS15025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS15030	COG0601	transmembrane transport
FY146_RS15035	COG0747	negative chemotaxis
FY146_RS15040	COG2186	Transcriptional regulator
FY146_RS15050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS15055	COG2223	nitrite transmembrane transporter activity
FY146_RS15065	COG3383	formate dehydrogenase (NAD+) activity
FY146_RS15085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_RS15100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_RS15110	COG0765	amino acid transport
FY146_RS15115	COG0765	amino acid transport
FY146_RS15120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS15135	COG3938	Belongs to the proline racemase family
FY146_RS15145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS15155	COG0765	amino acid transport
FY146_RS15170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_RS15175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS15185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_RS15190	COG0784	Response regulator, receiver
FY146_RS15205	COG0842	Transport permease protein
FY146_RS15210	COG1129	ABC transporter
FY146_RS15210	COG0842	Transport permease protein
FY146_RS15215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS15220	COG1486	melibiose metabolic process
FY146_RS15225	COG4172	Belongs to the ABC transporter superfamily
FY146_RS15230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS15235	COG0601	transmembrane transport
FY146_RS15240	COG0747	negative chemotaxis
FY146_RS15245	COG1486	melibiose metabolic process
FY146_RS15270	COG1940	carbohydrate kinase activity
FY146_RS15275	COG2182	Extracellular solute-binding protein
FY146_RS15280	COG1175	transmembrane transport
FY146_RS15285	COG0395	ABC-type sugar transport system, permease component
FY146_RS15290	COG0165	Argininosuccinate lyase
FY146_RS15295	COG3842	ATPase activity
FY146_RS15300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS15305	COG3119	arylsulfatase activity
FY146_RS15315	COG0583	DNA-binding transcription factor activity
FY146_RS15320	COG1120	ATPase activity
FY146_RS15325	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS15330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS15340	COG4774	siderophore transport
FY146_RS15355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY146_RS15370	COG2205	protein histidine kinase activity
FY146_RS15375	COG0745	RESPONSE REGULATOR receiver
FY146_RS15380	COG1566	PFAM secretion protein HlyD family protein
FY146_RS15395	COG1392	Phosphate transport regulator
FY146_RS15400	COG0306	phosphate transporter
FY146_RS15405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY146_RS15415	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY146_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS15430	COG5001	Diguanylate cyclase
FY146_RS15430	COG3300	MHYT domain
FY146_RS15450	COG2186	Transcriptional regulator
FY146_RS15455	COG0601	transmembrane transport
FY146_RS15460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS15465	COG0444	Belongs to the ABC transporter superfamily
FY146_RS15475	COG3842	ATPase activity
FY146_RS15480	COG0395	ABC-type sugar transport system, permease component
FY146_RS15495	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_RS15495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_RS15500	COG1609	Transcriptional regulator
FY146_RS15510	COG0210	DNA helicase
FY146_RS15515	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY146_RS15520	COG1088	dTDP-glucose 4,6-dehydratase activity
FY146_RS15525	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY146_RS15530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY146_RS15545	COG3754	Rhamnan synthesis protein F
FY146_RS15550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_RS15570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FY146_RS15580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FY146_RS15585	COG1216	Glycosyl transferase, family 2
FY146_RS15585	COG1442	glycosyl transferase family 8
FY146_RS15600	COG1132	(ABC) transporter
FY146_RS15610	COG0583	DNA-binding transcription factor activity
FY146_RS15615	COG0667	Aldo Keto reductase
FY146_RS15635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY146_RS15650	COG0300	oxidoreductase activity
FY146_RS15655	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_RS15660	COG1940	carbohydrate kinase activity
FY146_RS15670	COG3712	iron ion homeostasis
FY146_RS15675	COG4774	siderophore transport
FY146_RS15680	COG2814	Major facilitator Superfamily
FY146_RS15700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY146_RS15710	COG3842	ATPase activity
FY146_RS15715	COG1175	transmembrane transport
FY146_RS15720	COG0395	ABC-type sugar transport system, permease component
FY146_RS15725	COG1609	Transcriptional regulator
FY146_RS15735	COG0673	inositol 2-dehydrogenase activity
FY146_RS15740	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS15755	COG1609	Transcriptional regulator
FY146_RS15760	COG0183	Belongs to the thiolase family
FY146_RS15765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY146_RS15775	COG1414	Transcriptional regulator
FY146_RS15790	COG0583	DNA-binding transcription factor activity
FY146_RS15800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY146_RS15805	COG3485	protocatechuate 3,4-dioxygenase
FY146_RS15810	COG3485	protocatechuate 3,4-dioxygenase
FY146_RS15815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY146_RS15820	COG0765	amino acid transport
FY146_RS15825	COG0765	amino acid transport
FY146_RS15830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS15840	COG1126	abc transporter atp-binding protein
FY146_RS15845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY146_RS15850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY146_RS15875	COG4172	Belongs to the ABC transporter superfamily
FY146_RS15880	COG0747	negative chemotaxis
FY146_RS15890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS15905	COG0683	leucine binding
FY146_RS15920	COG0411	ABC transporter
FY146_RS15935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS15940	COG3962	Belongs to the TPP enzyme family
FY146_RS15950	COG3718	enzyme involved in inositol metabolism
FY146_RS15960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_RS15965	COG1609	Transcriptional regulator
FY146_RS15970	COG1846	Transcriptional regulator
FY146_RS15980	COG0523	cobalamin synthesis protein
FY146_RS16020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY146_RS16040	COG0800	Aldolase
FY146_RS16045	COG2954	triphosphatase activity
FY146_RS16055	COG1054	Belongs to the UPF0176 family
FY146_RS16060	COG3300	MHYT domain
FY146_RS16060	COG5001	Diguanylate cyclase
FY146_RS16070	COG2011	ABC-type metal ion transport system permease component
FY146_RS16075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY146_RS16080	COG0778	Nitroreductase
FY146_RS16090	COG2115	Belongs to the xylose isomerase family
FY146_RS16095	COG1070	Carbohydrate kinase
FY146_RS16100	COG1609	Transcriptional regulator
FY146_RS16120	COG1309	transcriptional regulator
FY146_RS16125	COG1253	flavin adenine dinucleotide binding
FY146_RS16130	COG3273	potassium ion transport
FY146_RS16130	COG0471	metal ion transport
FY146_RS16135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY146_RS16140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY146_RS16145	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_RS16155	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY146_RS16160	COG1121	(ABC) transporter
FY146_RS16165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_RS16170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS16185	COG1414	Transcriptional regulator
FY146_RS16190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY146_RS16210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_RS16260	COG0395	ABC-type sugar transport system, permease component
FY146_RS16265	COG1175	transmembrane transport
FY146_RS16275	COG2390	Transcriptional regulator
FY146_RS16280	COG4172	Belongs to the ABC transporter superfamily
FY146_RS16285	COG1473	amidohydrolase
FY146_RS16295	COG0601	transmembrane transport
FY146_RS16300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS16310	COG0693	protein deglycase activity
FY146_RS16315	COG0154	amidase activity
FY146_RS16320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS16330	COG0747	negative chemotaxis
FY146_RS16335	COG0583	DNA-binding transcription factor activity
FY146_RS16340	COG4608	Belongs to the ABC transporter superfamily
FY146_RS16345	COG0444	Belongs to the ABC transporter superfamily
FY146_RS16350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS16355	COG0601	transmembrane transport
FY146_RS16360	COG0747	negative chemotaxis
FY146_RS16375	COG1473	amidohydrolase
FY146_RS16380	COG2814	Major facilitator Superfamily
FY146_RS16385	COG0583	DNA-binding transcription factor activity
FY146_RS16390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY146_RS16400	COG3842	ATPase activity
FY146_RS16410	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS16420	COG1609	Transcriptional regulator
FY146_RS16425	COG0583	DNA-binding transcription factor activity
FY146_RS16430	COG1960	acyl-CoA dehydrogenase activity
FY146_RS16435	COG1629	transport
FY146_RS16435	COG4774	siderophore transport
FY146_RS16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS16455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS16470	COG2375	cellular response to nickel ion
FY146_RS16480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY146_RS16485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY146_RS16485	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY146_RS16495	COG1169	isochorismate synthase
FY146_RS16500	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY146_RS16505	COG3433	isochorismatase activity
FY146_RS16505	COG1535	isochorismatase
FY146_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS16525	COG3005	denitrification pathway
FY146_RS16535	COG0243	molybdopterin cofactor binding
FY146_RS16550	COG4459	periplasmic nitrate reductase
FY146_RS16585	COG0826	peptidase U32
FY146_RS16595	COG3189	MarR family transcriptional regulator
FY146_RS16600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY146_RS16635	COG3256	nitric oxide reductase
FY146_RS16640	COG0714	Associated with various cellular activities
FY146_RS16700	COG0673	inositol 2-dehydrogenase activity
FY146_RS16710	COG1609	Transcriptional regulator
FY146_RS16715	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS16720	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS16725	COG1129	ABC transporter
FY146_RS16730	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS16740	COG0583	DNA-binding transcription factor activity
FY146_RS16755	COG1609	Transcriptional regulator
FY146_RS16760	COG0673	inositol 2-dehydrogenase activity
FY146_RS16770	COG1653	transport
FY146_RS16775	COG1175	transmembrane transport
FY146_RS16780	COG0395	ABC-type sugar transport system, permease component
FY146_RS16785	COG3842	ATPase activity
FY146_RS16800	COG1253	flavin adenine dinucleotide binding
FY146_RS16825	COG5001	Diguanylate cyclase
FY146_RS16825	COG3300	MHYT domain
FY146_RS16955	COG0477	Major facilitator Superfamily
FY146_RS16975	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS16985	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS16995	COG1063	alcohol dehydrogenase
FY146_RS17010	COG1136	(ABC) transporter
FY146_RS17025	COG1309	transcriptional regulator
FY146_RS17050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY146_RS17060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_RS17060	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_RS17070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS17075	COG0047	phosphoribosylformylglycinamidine synthase activity
FY146_RS17085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS17090	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS17095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS17105	COG3448	diguanylate cyclase activity
FY146_RS17105	COG4175	Glycine betaine
FY146_RS17115	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_RS17120	COG3938	Belongs to the proline racemase family
FY146_RS17125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY146_RS17130	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS17160	COG1733	regulation of RNA biosynthetic process
FY146_RS17210	COG0477	Major facilitator Superfamily
FY146_RS17220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY146_RS17230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY146_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS17255	COG0395	ABC-type sugar transport system, permease component
FY146_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS17285	COG1349	DNA-binding transcription factor activity
FY146_RS17290	COG1069	ribulokinase activity
FY146_RS17310	COG1940	carbohydrate kinase activity
FY146_RS17325	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS17330	COG1177	transmembrane transport
FY146_RS17340	COG3842	ATPase activity
FY146_RS17400	COG0577	efflux transmembrane transporter activity
FY146_RS17400	COG1136	(ABC) transporter
FY146_RS17425	COG1845	cytochrome c oxidase, subunit III
FY146_RS17430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_RS17435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY146_RS17440	COG3474	cytochrome
FY146_RS17470	COG3842	ATPase activity
FY146_RS17475	COG0395	ABC-type sugar transport system, permease component
FY146_RS17480	COG1175	transmembrane transport
FY146_RS17485	COG1653	transport
FY146_RS17490	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS17495	COG1024	Enoyl-CoA hydratase
FY146_RS17515	COG4702	Belongs to the UPF0303 family
FY146_RS17520	COG4774	siderophore transport
FY146_RS17520	COG1629	transport
FY146_RS17525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FY146_RS17530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS17535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS17540	COG1120	ATPase activity
FY146_RS17555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY146_RS17565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY146_RS17570	COG1177	transmembrane transport
FY146_RS17575	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS17580	COG3842	ATPase activity
FY146_RS17605	COG1335	isochorismatase
FY146_RS17620	COG0583	DNA-binding transcription factor activity
FY146_RS17625	COG2318	DinB family
FY146_RS17650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_RS17680	COG0778	Nitroreductase
FY146_RS17700	COG0277	FAD linked oxidase domain protein
FY146_RS17720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS17725	COG4172	Belongs to the ABC transporter superfamily
FY146_RS17735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS17745	COG0431	NADPH-dependent FMN reductase
FY146_RS17765	COG1522	sequence-specific DNA binding
FY146_RS17770	COG2376	Dihydroxyacetone kinase
FY146_RS17780	COG4221	oxidoreductase activity
FY146_RS17785	COG0625	glutathione transferase activity
FY146_RS17795	COG1566	PFAM secretion protein HlyD family protein
FY146_RS17805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_RS17810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_RS17825	COG0534	Mate efflux family protein
FY146_RS17860	COG1733	regulation of RNA biosynthetic process
FY146_RS17870	COG0577	efflux transmembrane transporter activity
FY146_RS17870	COG1136	(ABC) transporter
FY146_RS17875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS17885	COG0745	RESPONSE REGULATOR receiver
FY146_RS17905	COG3209	COG3209 Rhs family protein
FY146_RS17935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS17960	COG3177	Filamentation induced by cAMP protein fic
FY146_RS17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS17980	COG4597	amino acid ABC transporter
FY146_RS17985	COG0765	amino acid transport
FY146_RS18010	COG0747	negative chemotaxis
FY146_RS18015	COG0601	transmembrane transport
FY146_RS18020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS18025	COG0444	Belongs to the ABC transporter superfamily
FY146_RS18030	COG4608	Belongs to the ABC transporter superfamily
FY146_RS18050	COG4213	ABC transporter substrate-binding protein
FY146_RS18055	COG1129	ABC transporter
FY146_RS18060	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS18075	COG0667	Aldo Keto reductase
FY146_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS18105	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS18110	COG1129	ABC transporter
FY146_RS18120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS18130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS18140	COG0747	negative chemotaxis
FY146_RS18145	COG0747	negative chemotaxis
FY146_RS18150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS18160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS18165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS18170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_RS18180	COG0405	Gamma-glutamyltransferase
FY146_RS18210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS18215	COG0436	Aminotransferase
FY146_RS18230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS18235	COG0765	amino acid transport
FY146_RS18245	COG1126	abc transporter atp-binding protein
FY146_RS18255	COG2186	Transcriptional regulator
FY146_RS18275	COG1846	Transcriptional regulator
FY146_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS18290	COG0583	DNA-binding transcription factor activity
FY146_RS18325	COG0583	DNA-binding transcription factor activity
FY146_RS18345	COG1280	lysine exporter protein (LysE YggA)
FY146_RS18350	COG3920	Histidine kinase
FY146_RS18375	COG0753	catalase activity
FY146_RS18395	COG1278	Cold shock
FY146_RS18435	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS18440	COG1902	pentaerythritol trinitrate reductase activity
FY146_RS18445	COG4221	oxidoreductase activity
FY146_RS18450	COG1309	transcriptional regulator
FY146_RS18465	COG1280	lysine exporter protein (LysE YggA)
FY146_RS18475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY146_RS18515	COG0739	heme binding
FY146_RS18515	COG0741	lytic transglycosylase activity
FY146_RS18515	COG1196	nuclear chromosome segregation
FY146_RS18520	COG0542	response to heat
FY146_RS18530	COG2890	protein-(glutamine-N5) methyltransferase activity
FY146_RS18535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY146_RS18545	COG0527	aspartate kinase activity
FY146_RS18560	COG0019	diaminopimelate decarboxylase activity
FY146_RS18575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY146_RS18595	COG0784	Response regulator, receiver
FY146_RS18610	COG1522	sequence-specific DNA binding
FY146_RS18620	COG1116	anion transmembrane transporter activity
FY146_RS18625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS18630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS18635	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS18640	COG0583	DNA-binding transcription factor activity
FY146_RS18645	COG0435	Glutathione S-transferase
FY146_RS18660	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY146_RS18665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS18670	COG0189	ligase activity
FY146_RS18690	COG0693	protein deglycase activity
FY146_RS18720	COG3685	Protein conserved in bacteria
FY146_RS18725	COG4993	Dehydrogenase
FY146_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS18745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY146_RS18790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS18805	COG0246	Mannitol dehydrogenase
FY146_RS18810	COG4608	Belongs to the ABC transporter superfamily
FY146_RS18815	COG0444	Belongs to the ABC transporter superfamily
FY146_RS18820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS18825	COG0601	transmembrane transport
FY146_RS18830	COG0747	negative chemotaxis
FY146_RS18840	COG4221	oxidoreductase activity
FY146_RS18870	COG0539	negative regulation of cytoplasmic translation
FY146_RS18875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY146_RS18905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY146_RS18910	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY146_RS18940	COG1294	oxidase, subunit
FY146_RS18950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY146_RS18955	COG4988	ABC transporter
FY146_RS18965	COG1063	alcohol dehydrogenase
FY146_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS18975	COG2084	Dehydrogenase
FY146_RS18985	COG1522	sequence-specific DNA binding
FY146_RS18990	COG1794	racemase activity, acting on amino acids and derivatives
FY146_RS19005	COG0058	SHG alpha-glucan phosphorylase activity
FY146_RS19010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY146_RS19015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY146_RS19020	COG0297	glycogen (starch) synthase activity
FY146_RS19025	COG0033	Phosphoglucomutase
FY146_RS19030	COG1523	belongs to the glycosyl hydrolase 13 family
FY146_RS19060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_RS19060	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_RS19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS19080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY146_RS19100	COG1215	transferase activity, transferring glycosyl groups
FY146_RS19105	COG2327	Polysaccharide pyruvyl transferase
FY146_RS19110	COG0463	Glycosyl transferase, family 2
FY146_RS19115	COG2244	polysaccharide biosynthetic process
FY146_RS19120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY146_RS19125	COG2273	Hydrolase Family 16
FY146_RS19130	COG0438	transferase activity, transferring glycosyl groups
FY146_RS19135	COG1215	transferase activity, transferring glycosyl groups
FY146_RS19140	COG1215	transferase activity, transferring glycosyl groups
FY146_RS19145	COG1215	transferase activity, transferring glycosyl groups
FY146_RS19150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY146_RS19155	COG3206	protein involved in exopolysaccharide biosynthesis
FY146_RS19155	COG0489	protein tyrosine kinase activity
FY146_RS19160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_RS19165	COG0784	Response regulator, receiver
FY146_RS19165	COG4191	Histidine kinase
FY146_RS19180	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_RS19185	COG4175	Glycine betaine
FY146_RS19185	COG3448	diguanylate cyclase activity
FY146_RS19200	COG0564	pseudouridine synthase activity
FY146_RS19205	COG0500	methyltransferase
FY146_RS19215	COG2133	pyrroloquinoline quinone binding
FY146_RS19225	COG2197	response regulator
FY146_RS19230	COG4585	Histidine kinase
FY146_RS19235	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS19240	COG1129	ABC transporter
FY146_RS19245	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS19255	COG3386	PFAM SMP-30 Gluconolaconase
FY146_RS19260	COG2137	regulation of response to DNA damage stimulus
FY146_RS19265	COG3474	cytochrome
FY146_RS19275	COG1120	ATPase activity
FY146_RS19290	COG4774	siderophore transport
FY146_RS19295	COG0583	DNA-binding transcription factor activity
FY146_RS19305	COG2194	sulfuric ester hydrolase activity
FY146_RS19320	COG0477	Major facilitator Superfamily
FY146_RS19340	COG0673	inositol 2-dehydrogenase activity
FY146_RS19345	COG0697	spore germination
FY146_RS19355	COG0010	Belongs to the arginase family
FY146_RS19370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY146_RS19375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_RS19380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY146_RS19385	COG0156	8-amino-7-oxononanoate synthase activity
FY146_RS19390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY146_RS19440	COG0671	phosphoesterase, PA-phosphatase related
FY146_RS19445	COG0745	RESPONSE REGULATOR receiver
FY146_RS19450	COG2205	protein histidine kinase activity
FY146_RS19460	COG0477	Major facilitator Superfamily
FY146_RS19465	COG0583	DNA-binding transcription factor activity
FY146_RS19485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY146_RS19500	COG0346	lactoylglutathione lyase activity
FY146_RS19505	COG0583	DNA-binding transcription factor activity
FY146_RS19535	COG1215	transferase activity, transferring glycosyl groups
FY146_RS19555	COG0840	transmembrane signaling receptor activity
FY146_RS19570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS19585	COG2828	Protein conserved in bacteria
FY146_RS19590	COG0583	DNA-binding transcription factor activity
FY146_RS19595	COG1846	Transcriptional regulator
FY146_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS19625	COG1309	transcriptional regulator
FY146_RS19630	COG2207	Transcriptional regulator
FY146_RS19645	COG1566	PFAM secretion protein HlyD family protein
FY146_RS19665	COG0395	ABC-type sugar transport system, permease component
FY146_RS19670	COG4166	transmembrane transport
FY146_RS19675	COG0601	transmembrane transport
FY146_RS19680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS19685	COG4172	Belongs to the ABC transporter superfamily
FY146_RS19725	COG0402	S-adenosylhomocysteine deaminase activity
FY146_RS19730	COG1228	amidohydrolase
FY146_RS19735	COG2986	histidine ammonia-lyase
FY146_RS19745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY146_RS19775	COG1192	Involved in chromosome partitioning
FY146_RS19780	COG1475	DNA binding
FY146_RS19785	COG1414	Transcriptional regulator
FY146_RS19805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_RS19810	COG4771	TonB-dependent receptor
FY146_RS19820	COG0366	Alpha amylase catalytic
FY146_RS19825	COG4770	biotin carboxylase activity
FY146_RS19830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_RS19835	COG4336	lyase activity
FY146_RS19840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_RS19845	COG1914	H( )-stimulated, divalent metal cation uptake system
FY146_RS19850	COG1802	Transcriptional regulator
FY146_RS19855	COG3707	response regulator
FY146_RS19865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS19875	COG1116	anion transmembrane transporter activity
FY146_RS19880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY146_RS19890	COG0243	molybdopterin cofactor binding
FY146_RS19895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY146_RS19895	COG1648	precorrin-2 dehydrogenase activity
FY146_RS19910	COG3842	ATPase activity
FY146_RS19925	COG0395	ABC-type sugar transport system, permease component
FY146_RS19940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY146_RS19955	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_RS20000	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS20005	COG1129	ABC transporter
FY146_RS20010	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS20020	COG0667	Aldo Keto reductase
FY146_RS20025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY146_RS20030	COG1830	Aldolase
FY146_RS20035	COG1070	Carbohydrate kinase
FY146_RS20040	COG0840	transmembrane signaling receptor activity
FY146_RS20055	COG0436	Aminotransferase
FY146_RS20065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_RS20075	COG3842	ATPase activity
FY146_RS20080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_RS20085	COG1984	allophanate hydrolase subunit 2
FY146_RS20090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_RS20100	COG0439	Biotin carboxylase
FY146_RS20105	COG0511	ligase activity, forming carbon-carbon bonds
FY146_RS20110	COG0697	spore germination
FY146_RS20115	COG0697	spore germination
FY146_RS20130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_RS20145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS20155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_RS20160	COG4221	oxidoreductase activity
FY146_RS20165	COG0765	amino acid transport
FY146_RS20170	COG0765	amino acid transport
FY146_RS20180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS20185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_RS20190	COG1063	alcohol dehydrogenase
FY146_RS20205	COG1304	FMN binding
FY146_RS20230	COG3842	ATPase activity
FY146_RS20240	COG0395	ABC-type sugar transport system, permease component
FY146_RS20245	COG1175	transmembrane transport
FY146_RS20260	COG2186	Transcriptional regulator
FY146_RS20265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_RS20270	COG0488	(ABC) transporter
FY146_RS20285	COG2308	Evidence 4 Homologs of previously reported genes of
FY146_RS20285	COG2307	Protein conserved in bacteria
FY146_RS20325	COG1454	alcohol dehydrogenase
FY146_RS20330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_RS20340	COG0747	negative chemotaxis
FY146_RS20345	COG0601	transmembrane transport
FY146_RS20350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS20360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS20405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_RS20430	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS20435	COG0673	inositol 2-dehydrogenase activity
FY146_RS20440	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS20460	COG1609	Transcriptional regulator
FY146_RS20465	COG2986	histidine ammonia-lyase
FY146_RS20470	COG0517	IMP dehydrogenase activity
FY146_RS20470	COG4175	Glycine betaine
FY146_RS20475	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_RS20515	COG2186	Transcriptional regulator
FY146_RS20520	COG1027	Aspartate ammonia-lyase
FY146_RS20530	COG0252	asparaginase activity
FY146_RS20540	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY146_RS20550	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY146_RS20555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY146_RS20560	COG2205	protein histidine kinase activity
FY146_RS20575	COG0067	glutamate synthase
FY146_RS20575	COG0069	glutamate synthase activity
FY146_RS20575	COG0070	glutamate synthase
FY146_RS20590	COG2205	protein histidine kinase activity
FY146_RS20605	COG2951	lytic endotransglycosylase activity
FY146_RS20610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY146_RS20635	COG0330	HflC and HflK could
FY146_RS20640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY146_RS20645	COG0737	Belongs to the 5'-nucleotidase family
FY146_RS20655	COG5310	Homospermidine synthase
FY146_RS20665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_RS20670	COG1164	Oligoendopeptidase f
FY146_RS20675	COG2204	response regulator
FY146_RS20680	COG3108	Peptidase M15
FY146_RS20685	COG0469	pyruvate kinase activity
FY146_RS20705	COG3750	Belongs to the UPF0335 family
FY146_RS20710	COG0457	Tetratricopeptide repeat
FY146_RS20715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY146_RS20720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY146_RS20725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY146_RS20755	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS20775	COG1132	(ABC) transporter
FY146_RS20780	COG0254	rRNA binding
FY146_RS20805	COG3588	fructose-bisphosphate aldolase
FY146_RS20810	COG0126	phosphoglycerate kinase activity
FY146_RS20815	COG3263	regulation of cellular component size
FY146_RS20850	COG1253	flavin adenine dinucleotide binding
FY146_RS20860	COG1692	metallophosphoesterase
FY146_RS20875	COG0217	transcriptional regulatory protein
FY146_RS20880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS20885	COG0840	transmembrane signaling receptor activity
FY146_RS20890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY146_RS20895	COG0632	four-way junction helicase activity
FY146_RS20900	COG2255	four-way junction helicase activity
FY146_RS20915	COG0494	nUDIX hydrolase
FY146_RS20925	COG0824	Thioesterase
FY146_RS20945	COG0823	Involved in the tonB-independent uptake of proteins
FY146_RS20950	COG2885	chlorophyll binding
FY146_RS20960	COG0037	tRNA processing
FY146_RS20965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_RS20970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY146_RS20985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_RS21000	COG0482	sulfurtransferase activity
FY146_RS21030	COG2835	tetraacyldisaccharide 4'-kinase activity
FY146_RS21035	COG2373	Large extracellular alpha-helical protein
FY146_RS21040	COG4953	penicillin-binding protein 1C
FY146_RS21050	COG1473	amidohydrolase
FY146_RS21055	COG1686	Belongs to the peptidase S11 family
FY146_RS21060	COG0523	cobalamin synthesis protein
FY146_RS21065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY146_RS21065	COG0425	Belongs to the sulfur carrier protein TusA family
FY146_RS21070	COG3034	peptidoglycan biosynthetic process
FY146_RS21075	COG0825	malonyl-CoA metabolic process
FY146_RS21080	COG4974	Belongs to the 'phage' integrase family
FY146_RS21090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY146_RS21095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY146_RS21135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY146_RS21140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY146_RS21160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_RS21165	COG2226	methyltransferase
FY146_RS21170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY146_RS21175	COG0287	Prephenate dehydrogenase
FY146_RS21185	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY146_RS21205	COG2884	Cell division ATP-binding protein ftsE
FY146_RS21240	COG0165	Argininosuccinate lyase
FY146_RS21245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY146_RS21255	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY146_RS21265	COG2086	electron transfer activity
FY146_RS21275	COG2096	Adenosyltransferase
FY146_RS21285	COG0300	oxidoreductase activity
FY146_RS21295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY146_RS21305	COG1396	sequence-specific DNA binding
FY146_RS21305	COG3800	Transcriptional regulator
FY146_RS21310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY146_RS21315	COG0625	glutathione transferase activity
FY146_RS21330	COG4770	biotin carboxylase activity
FY146_RS21335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY146_RS21335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY146_RS21340	COG0346	lactoylglutathione lyase activity
FY146_RS21355	COG4213	ABC transporter substrate-binding protein
FY146_RS21360	COG4214	carbohydrate transport
FY146_RS21365	COG1129	ABC transporter
FY146_RS21370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY146_RS21380	COG1396	sequence-specific DNA binding
FY146_RS21435	COG3833	ABC-type maltose transport systems, permease component
FY146_RS21440	COG3842	ATPase activity
FY146_RS21455	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY146_RS21455	COG2273	Hydrolase Family 16
FY146_RS21460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY146_RS21475	COG0438	transferase activity, transferring glycosyl groups
FY146_RS21480	COG0438	transferase activity, transferring glycosyl groups
FY146_RS21500	COG3206	protein involved in exopolysaccharide biosynthesis
FY146_RS21500	COG0489	protein tyrosine kinase activity
FY146_RS21510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY146_RS21525	COG2244	polysaccharide biosynthetic process
FY146_RS21590	COG0697	spore germination
FY146_RS21595	COG0653	protein targeting
FY146_RS21600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY146_RS21605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY146_RS21615	COG0494	nUDIX hydrolase
FY146_RS21630	COG2226	methyltransferase
FY146_RS21635	COG1040	competence protein
FY146_RS21645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_RS21655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_RS21670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY146_RS21675	COG4150	thiosulfate binding
FY146_RS21685	COG4208	sulfate ABC transporter
FY146_RS21690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_RS21695	COG4335	DNA alkylation repair
FY146_RS21710	COG5001	Diguanylate cyclase
FY146_RS21715	COG2264	protein methyltransferase activity
FY146_RS21730	COG3254	rhamnose metabolic process
FY146_RS21735	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS21740	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS21745	COG1129	ABC transporter
FY146_RS21755	COG1349	DNA-binding transcription factor activity
FY146_RS21760	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS21760	COG3347	Dehydrogenase
FY146_RS21765	COG4952	isomerase
FY146_RS21770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY146_RS21775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY146_RS21795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY146_RS21800	COG1960	acyl-CoA dehydrogenase activity
FY146_RS21810	COG0183	Belongs to the thiolase family
FY146_RS21815	COG1960	acyl-CoA dehydrogenase activity
FY146_RS21825	COG0022	dehydrogenase e1 component
FY146_RS21835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY146_RS21840	COG2391	methyltransferase activity
FY146_RS21850	COG0640	Transcriptional regulator
FY146_RS21855	COG3453	Protein conserved in bacteria
FY146_RS21855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_RS21865	COG0300	oxidoreductase activity
FY146_RS21880	COG2186	Transcriptional regulator
FY146_RS21890	COG0601	transmembrane transport
FY146_RS21900	COG0444	Belongs to the ABC transporter superfamily
FY146_RS21905	COG4608	Belongs to the ABC transporter superfamily
FY146_RS22040	COG2369	cell adhesion
FY146_RS22045	COG4383	Mu-like prophage protein gp29
FY146_RS22050	COG4373	Mu-like prophage FluMu protein gp28
FY146_RS22185	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS22190	COG1733	regulation of RNA biosynthetic process
FY146_RS22200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22225	COG1473	amidohydrolase
FY146_RS22230	COG0747	negative chemotaxis
FY146_RS22245	COG4166	transmembrane transport
FY146_RS22250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22255	COG0583	DNA-binding transcription factor activity
FY146_RS22265	COG0667	Aldo Keto reductase
FY146_RS22275	COG0444	Belongs to the ABC transporter superfamily
FY146_RS22290	COG0747	negative chemotaxis
FY146_RS22300	COG1960	acyl-CoA dehydrogenase activity
FY146_RS22330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_RS22345	COG1959	2 iron, 2 sulfur cluster binding
FY146_RS22350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22360	COG1473	amidohydrolase
FY146_RS22375	COG1126	abc transporter atp-binding protein
FY146_RS22380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS22390	COG0583	DNA-binding transcription factor activity
FY146_RS22405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS22415	COG1522	sequence-specific DNA binding
FY146_RS22420	COG4172	Belongs to the ABC transporter superfamily
FY146_RS22425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS22460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS22465	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS22470	COG0473	3-isopropylmalate dehydrogenase activity
FY146_RS22475	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS22520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS22525	COG1120	ATPase activity
FY146_RS22535	COG2226	methyltransferase
FY146_RS22550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS22555	COG1120	ATPase activity
FY146_RS22560	COG1595	DNA-templated transcription, initiation
FY146_RS22580	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY146_RS22585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS22605	COG0673	inositol 2-dehydrogenase activity
FY146_RS22610	COG0673	inositol 2-dehydrogenase activity
FY146_RS22620	COG1175	transmembrane transport
FY146_RS22625	COG0395	ABC-type sugar transport system, permease component
FY146_RS22630	COG3842	ATPase activity
FY146_RS22640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS22645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_RS22650	COG2197	response regulator
FY146_RS22655	COG0601	transmembrane transport
FY146_RS22660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS22680	COG0747	negative chemotaxis
FY146_RS22695	COG1446	asparaginase
FY146_RS22700	COG0583	DNA-binding transcription factor activity
FY146_RS22705	COG0601	transmembrane transport
FY146_RS22710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS22725	COG0747	negative chemotaxis
FY146_RS22730	COG1473	amidohydrolase
FY146_RS22745	COG1129	ABC transporter
FY146_RS22750	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS22755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY146_RS22760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY146_RS22770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_RS22785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS22795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS22800	COG2079	MmgE PrpD family protein
FY146_RS22805	COG1126	abc transporter atp-binding protein
FY146_RS22810	COG0765	amino acid transport
FY146_RS22825	COG0281	malic enzyme
FY146_RS22825	COG0280	phosphate acetyltransferase
FY146_RS22830	COG0583	DNA-binding transcription factor activity
FY146_RS22855	COG1175	transmembrane transport
FY146_RS22860	COG0395	ABC-type sugar transport system, permease component
FY146_RS22875	COG0673	inositol 2-dehydrogenase activity
FY146_RS22885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY146_RS22890	COG0720	synthase
FY146_RS22895	COG0602	queuosine metabolic process
FY146_RS22900	COG0673	inositol 2-dehydrogenase activity
FY146_RS22910	COG3842	ATPase activity
FY146_RS22925	COG1653	transport
FY146_RS22930	COG1609	Transcriptional regulator
FY146_RS22945	COG2094	Belongs to the DNA glycosylase MPG family
FY146_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS22965	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_RS22970	COG0840	transmembrane signaling receptor activity
FY146_RS22975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_RS22985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY146_RS22990	COG1596	polysaccharide export
FY146_RS22995	COG3307	-O-antigen
FY146_RS23025	COG2197	response regulator
FY146_RS23035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS23060	COG2942	2-epimerase
FY146_RS23070	COG1215	transferase activity, transferring glycosyl groups
FY146_RS23090	COG1473	amidohydrolase
FY146_RS23100	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS23105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_RS23110	COG1301	dicarboxylic acid transport
FY146_RS23115	COG4191	Histidine kinase
FY146_RS23120	COG2204	response regulator
FY146_RS23135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS23140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY146_RS23145	COG1522	sequence-specific DNA binding
FY146_RS23150	COG0351	phosphomethylpyrimidine kinase
FY146_RS23155	COG0352	thiamine-phosphate diphosphorylase activity
FY146_RS23160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY146_RS23165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS23170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS23180	COG1501	Belongs to the glycosyl hydrolase 31 family
FY146_RS23185	COG0395	ABC-type sugar transport system, permease component
FY146_RS23190	COG1175	transmembrane transport
FY146_RS23195	COG1653	transport
FY146_RS23200	COG3842	ATPase activity
FY146_RS23205	COG2188	Transcriptional regulator
FY146_RS23215	COG4989	oxidoreductase activity
FY146_RS23250	COG0438	transferase activity, transferring glycosyl groups
FY146_RS23255	COG0747	negative chemotaxis
FY146_RS23260	COG0601	transmembrane transport
FY146_RS23270	COG3964	amidohydrolase
FY146_RS23285	COG1921	L-seryl-tRNASec selenium transferase activity
FY146_RS23290	COG4172	Belongs to the ABC transporter superfamily
FY146_RS23295	COG0625	glutathione transferase activity
FY146_RS23310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS23315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_RS23315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_RS23320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_RS23340	COG1312	Catalyzes the dehydration of D-mannonate
FY146_RS23345	COG1063	alcohol dehydrogenase
FY146_RS23350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_RS23360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_RS23365	COG2186	Transcriptional regulator
FY146_RS23370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY146_RS23375	COG0850	regulation of cytokinetic process
FY146_RS23380	COG2894	cell division
FY146_RS23385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY146_RS23390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS23400	COG5001	Diguanylate cyclase
FY146_RS23415	COG0673	inositol 2-dehydrogenase activity
FY146_RS23425	COG1653	transport
FY146_RS23430	COG1175	transmembrane transport
FY146_RS23435	COG0395	ABC-type sugar transport system, permease component
FY146_RS23440	COG3842	ATPase activity
FY146_RS23450	COG0673	inositol 2-dehydrogenase activity
FY146_RS23480	COG0587	DNA-directed DNA polymerase activity
FY146_RS23485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_RS23500	COG2186	Transcriptional regulator
FY146_RS23505	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS23510	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS23515	COG1129	ABC transporter
FY146_RS23520	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS23525	COG0129	dihydroxy-acid dehydratase activity
FY146_RS23535	COG0346	lactoylglutathione lyase activity
FY146_RS23550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY146_RS23555	COG4608	Belongs to the ABC transporter superfamily
FY146_RS23565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS23570	COG0601	transmembrane transport
FY146_RS23575	COG0747	negative chemotaxis
FY146_RS23585	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_RS23590	COG5001	Diguanylate cyclase
FY146_RS23600	COG3257	ureidoglycine aminohydrolase activity
FY146_RS23610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS23615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_RS23625	COG1129	ABC transporter
FY146_RS23630	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS23635	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS23640	COG0583	DNA-binding transcription factor activity
FY146_RS23665	COG3047	cAMP biosynthetic process
FY146_RS23675	COG3842	ATPase activity
FY146_RS23680	COG0395	ABC-type sugar transport system, permease component
FY146_RS23685	COG1175	transmembrane transport
FY146_RS23690	COG1653	transport
FY146_RS23695	COG0523	cobalamin synthesis protein
FY146_RS23710	COG0523	cobalamin synthesis protein
FY146_RS23715	COG1121	(ABC) transporter
FY146_RS23725	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY146_RS23730	COG0454	-acetyltransferase
FY146_RS23745	COG0626	cystathionine gamma-synthase activity
FY146_RS23750	COG2182	Extracellular solute-binding protein
FY146_RS23760	COG0395	ABC-type sugar transport system, permease component
FY146_RS23775	COG0395	ABC-type sugar transport system, permease component
FY146_RS23780	COG1175	transmembrane transport
FY146_RS23785	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY146_RS23790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_RS23800	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS23805	COG1063	alcohol dehydrogenase
FY146_RS23810	COG1609	Transcriptional regulator
FY146_RS23815	COG2223	nitrite transmembrane transporter activity
FY146_RS23820	COG4977	sequence-specific DNA binding
FY146_RS23850	COG0667	Aldo Keto reductase
FY146_RS23865	COG2186	Transcriptional regulator
FY146_RS23870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_RS23875	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY146_RS23880	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS23885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_RS23890	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS23895	COG3618	amidohydrolase
FY146_RS23905	COG1175	transmembrane transport
FY146_RS23910	COG0395	ABC-type sugar transport system, permease component
FY146_RS23915	COG3842	ATPase activity
FY146_RS23930	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY146_RS23935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_RS23960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY146_RS23970	COG1278	Cold shock
FY146_RS23980	COG0673	inositol 2-dehydrogenase activity
FY146_RS23995	COG0673	inositol 2-dehydrogenase activity
FY146_RS24000	COG1309	transcriptional regulator
FY146_RS24005	COG1653	transport
FY146_RS24010	COG1175	transmembrane transport
FY146_RS24015	COG0395	ABC-type sugar transport system, permease component
FY146_RS24020	COG3842	ATPase activity
FY146_RS24025	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS24040	COG1609	Transcriptional regulator
FY146_RS24070	COG1175	transmembrane transport
FY146_RS24075	COG0395	ABC-type sugar transport system, permease component
FY146_RS24080	COG1116	anion transmembrane transporter activity
FY146_RS24085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS24090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS24105	COG3842	ATPase activity
FY146_RS24110	COG0395	ABC-type sugar transport system, permease component
FY146_RS24120	COG1653	transport
FY146_RS24155	COG3842	ATPase activity
FY146_RS24165	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS24170	COG0395	ABC-type sugar transport system, permease component
FY146_RS24230	COG2233	PERMEase
FY146_RS24245	COG5002	protein histidine kinase activity
FY146_RS24250	COG0745	RESPONSE REGULATOR receiver
FY146_RS24255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_RS24260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_RS24265	COG0702	epimerase
FY146_RS24275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_RS24310	COG2235	arginine
FY146_RS24320	COG0628	permease
FY146_RS24340	COG1522	sequence-specific DNA binding
FY146_RS24360	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS24375	COG1414	Transcriptional regulator
FY146_RS24385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_RS24415	COG4566	intracellular signal transduction
FY146_RS24420	COG4566	intracellular signal transduction
FY146_RS24430	COG0243	molybdopterin cofactor binding
FY146_RS24435	COG0783	Belongs to the Dps family
FY146_RS24455	COG0596	Alpha beta hydrolase
FY146_RS24465	COG1764	response to oxidative stress
FY146_RS24480	COG0596	Alpha beta hydrolase
FY146_RS24515	COG4172	Belongs to the ABC transporter superfamily
FY146_RS24540	COG0601	transmembrane transport
FY146_RS24545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS24550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS24560	COG4106	trans-aconitate 2-methyltransferase activity
FY146_RS24565	COG0025	NhaP-type Na H and K H
FY146_RS24570	COG4302	ethanolamine ammonia-lyase activity
FY146_RS24595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_RS24600	COG1349	DNA-binding transcription factor activity
FY146_RS24605	COG4608	Belongs to the ABC transporter superfamily
FY146_RS24615	COG0601	transmembrane transport
FY146_RS24620	COG0747	negative chemotaxis
FY146_RS24625	COG1454	alcohol dehydrogenase
FY146_RS24630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_RS24635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY146_RS24640	COG0411	ABC transporter
FY146_RS24675	COG1278	Cold shock
FY146_RS24705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY146_RS24715	COG1192	Involved in chromosome partitioning
FY146_RS24720	COG1475	DNA binding
FY146_RS24725	COG0640	Transcriptional regulator
FY146_RS24740	COG1126	abc transporter atp-binding protein
FY146_RS24750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS24755	COG1609	Transcriptional regulator
FY146_RS24790	COG3239	Fatty acid desaturase
FY146_RS24800	COG1278	Cold shock
FY146_RS24880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY146_RS24880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_RS24920	COG4191	Histidine kinase
FY146_RS24935	COG0640	Transcriptional regulator
FY146_RS24965	COG4977	sequence-specific DNA binding
FY146_RS24970	COG2211	Major facilitator Superfamily
FY146_RS24975	COG2807	transmembrane transport
FY146_RS24980	COG1846	Transcriptional regulator
FY146_RS24995	COG2814	Major facilitator Superfamily
FY146_RS25025	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY146_RS25040	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY146_RS25045	COG0583	DNA-binding transcription factor activity
FY146_RS25060	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_RS25110	COG3838	Conjugal transfer protein Trbc
FY146_RS25115	COG3702	type iv secretory pathway
FY146_RS25120	COG3451	type IV secretory pathway VirB4
FY146_RS25135	COG3704	protein secretion by the type IV secretion system
FY146_RS25145	COG3736	Type IV secretory pathway, component VirB8
FY146_RS25150	COG3504	Conjugal transfer protein
FY146_RS25155	COG2948	multi-organism process
FY146_RS25160	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY146_RS25265	COG3831	ATPase activity
FY146_RS25280	COG3505	Type IV secretory pathway VirD4
FY146_RS25305	COG0583	DNA-binding transcription factor activity
FY146_RS25350	COG0745	RESPONSE REGULATOR receiver
FY146_RS25390	COG3842	ATPase activity
FY146_RS25395	COG4208	sulfate ABC transporter
FY146_RS25400	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS25420	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY146_RS25425	COG1942	4-Oxalocrotonate Tautomerase
FY146_RS25435	COG3971	2-oxopent-4-enoate hydratase activity
FY146_RS25445	COG1414	Transcriptional regulator
FY146_RS25455	COG1137	ATPase activity
FY146_RS25470	COG4177	L-phenylalanine transmembrane transporter activity
FY146_RS25490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY146_RS25495	COG1175	transmembrane transport
FY146_RS25500	COG0395	ABC-type sugar transport system, permease component
FY146_RS25510	COG0366	Alpha amylase catalytic
FY146_RS25515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_RS25520	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS25525	COG3842	ATPase activity
FY146_RS25535	COG1940	carbohydrate kinase activity
FY146_RS25540	COG0395	ABC-type sugar transport system, permease component
FY146_RS25550	COG2182	Extracellular solute-binding protein
FY146_RS25555	COG0673	inositol 2-dehydrogenase activity
FY146_RS25585	COG1126	abc transporter atp-binding protein
FY146_RS25590	COG0765	amino acid transport
FY146_RS25595	COG0765	amino acid transport
FY146_RS25605	COG4608	Belongs to the ABC transporter superfamily
FY146_RS25615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS25630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_RS25635	COG0583	DNA-binding transcription factor activity
FY146_RS25640	COG2423	ornithine cyclodeaminase activity
FY146_RS25650	COG1957	nucleoside hydrolase
FY146_RS25660	COG1309	transcriptional regulator
FY146_RS25670	COG1335	isochorismatase
FY146_RS25675	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS25680	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS25715	COG0251	oxidation-reduction process
FY146_RS25720	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY146_RS25775	COG4215	(ABC) transporter
FY146_RS25785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS25800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS25810	COG0747	negative chemotaxis
FY146_RS25815	COG0583	DNA-binding transcription factor activity
FY146_RS25830	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY146_RS25865	COG0477	Major facilitator Superfamily
FY146_RS25875	COG0395	ABC-type sugar transport system, permease component
FY146_RS25880	COG1175	transmembrane transport
FY146_RS25885	COG3842	ATPase activity
FY146_RS25895	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_RS25905	COG1414	Transcriptional regulator
FY146_RS25910	COG0583	DNA-binding transcription factor activity
FY146_RS25945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY146_RS25955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_RS25980	COG1129	ABC transporter
FY146_RS26000	COG2272	Belongs to the type-B carboxylesterase lipase family
FY146_RS26010	COG2271	Major facilitator Superfamily
FY146_RS26015	COG0583	DNA-binding transcription factor activity
FY146_RS26040	COG1129	ABC transporter
FY146_RS26050	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS26055	COG1940	carbohydrate kinase activity
FY146_RS26080	COG2084	Dehydrogenase
FY146_RS26085	COG3622	Belongs to the hyi family
FY146_RS26090	COG3386	PFAM SMP-30 Gluconolaconase
FY146_RS26100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY146_RS26110	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS26150	COG1846	Transcriptional regulator
FY146_RS26170	COG3706	GGDEF domain
FY146_RS26185	COG0477	Major facilitator Superfamily
FY146_RS26190	COG1012	belongs to the aldehyde dehydrogenase family
FY146_RS26200	COG1024	Enoyl-CoA hydratase
FY146_RS26205	COG1960	acyl-CoA dehydrogenase activity
FY146_RS26215	COG1063	alcohol dehydrogenase
FY146_RS26230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY146_RS26235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_RS26250	COG3971	2-oxopent-4-enoate hydratase activity
FY146_RS26255	COG3485	protocatechuate 3,4-dioxygenase
FY146_RS26260	COG1802	Transcriptional regulator
FY146_RS26320	COG2207	Transcriptional regulator
FY146_RS26405	COG1695	Transcriptional regulator
FY146_RS26415	COG0583	DNA-binding transcription factor activity
FY146_RS26420	COG1335	isochorismatase
FY146_RS26430	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS26435	COG0583	DNA-binding transcription factor activity
FY146_RS26440	COG1902	pentaerythritol trinitrate reductase activity
FY146_RS26445	COG0583	DNA-binding transcription factor activity
FY146_RS26490	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS26495	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS26500	COG1335	isochorismatase
FY146_RS26510	COG1309	transcriptional regulator
FY146_RS26515	COG4604	ABC transporter, ATP-binding protein
FY146_RS26520	COG4605	iron ion homeostasis
FY146_RS26525	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_RS26535	COG2132	Multicopper oxidase
FY146_RS26540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_RS26590	COG1695	Transcriptional regulator
FY146_RS26625	COG2132	Multicopper oxidase
FY146_RS26660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY146_RS26680	COG1192	Involved in chromosome partitioning
FY146_RS26685	COG1475	DNA binding
FY146_RS26690	COG0640	Transcriptional regulator
FY146_RS26695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_RS26725	COG2211	Major facilitator Superfamily
FY146_RS26775	COG1051	belongs to the nudix hydrolase family
FY146_RS26820	COG1475	DNA binding
FY146_RS26845	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_RS26865	COG1280	lysine exporter protein (LysE YggA)
FY146_RS26880	COG5489	Protein of unknown function (DUF736)
FY146_RS26945	COG1879	ABC-type sugar transport system periplasmic component
FY146_RS26950	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS26970	COG1280	lysine exporter protein (LysE YggA)
FY146_RS27055	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY146_RS27070	COG0747	negative chemotaxis
FY146_RS27075	COG0444	Belongs to the ABC transporter superfamily
FY146_RS27090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS27095	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_RS27100	COG0483	inositol monophosphate 1-phosphatase activity
FY146_RS27165	COG3161	chorismate lyase activity
FY146_RS27390	COG2222	sugar isomerase
FY146_RS27400	COG0006	proline dipeptidase activity
FY146_RS27420	COG1177	transmembrane transport
FY146_RS27425	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_RS27430	COG3842	ATPase activity
FY146_RS27460	COG3842	ATPase activity
FY146_RS27465	COG0006	proline dipeptidase activity
FY146_RS27485	COG0300	oxidoreductase activity
FY146_RS27490	COG0129	dihydroxy-acid dehydratase activity
FY146_RS27495	COG0667	Aldo Keto reductase
FY146_RS27505	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS27515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS27520	COG0601	transmembrane transport
FY146_RS27525	COG4172	Belongs to the ABC transporter superfamily
FY146_RS27535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_RS27570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS27605	COG3701	Conjugal transfer protein
FY146_RS27610	COG3846	protein secretion by the type IV secretion system
FY146_RS27620	COG5314	conjugation
FY146_RS27625	COG3451	type IV secretory pathway VirB4
FY146_RS27640	COG4962	Type ii secretion system protein e
FY146_RS27650	COG1192	Involved in chromosome partitioning
FY146_RS27655	COG1475	DNA binding
FY146_RS27660	COG0640	Transcriptional regulator
FY146_RS27665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_RS27710	COG0583	DNA-binding transcription factor activity
FY146_RS27720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_RS27725	COG1116	anion transmembrane transporter activity
FY146_RS27730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_RS27740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS27745	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_RS27775	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_RS27780	COG1129	ABC transporter
FY146_RS27805	COG4172	Belongs to the ABC transporter superfamily
FY146_RS27810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS27815	COG0601	transmembrane transport
FY146_RS27825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS27830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS27835	COG0583	DNA-binding transcription factor activity
FY146_RS27845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_RS27860	COG1132	(ABC) transporter
FY146_RS27865	COG4172	Belongs to the ABC transporter superfamily
FY146_RS27870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS27890	COG1082	Xylose isomerase domain protein TIM barrel
FY146_RS27895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_RS27900	COG0019	diaminopimelate decarboxylase activity
FY146_RS27910	COG1475	DNA binding
FY146_RS27920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_RS28015	COG1475	DNA binding
FY146_RS28040	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_RS28065	COG5489	Protein of unknown function (DUF736)
FY146_RS28130	COG0583	DNA-binding transcription factor activity
FY146_RS28135	COG1126	abc transporter atp-binding protein
FY146_RS28140	COG0765	amino acid transport
FY146_RS28145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_RS28150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS28155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_RS28215	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_RS28225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS28240	COG0444	Belongs to the ABC transporter superfamily
FY146_RS28265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_RS28270	COG0601	transmembrane transport
FY146_RS28285	COG0444	Belongs to the ABC transporter superfamily
FY146_RS28290	COG0747	negative chemotaxis
FY146_RS28300	COG2390	Transcriptional regulator
FY146_RS28345	COG0145	ligase activity
FY146_RS28355	COG0583	DNA-binding transcription factor activity
FY146_RS28400	COG3701	Conjugal transfer protein
FY146_RS28405	COG3846	protein secretion by the type IV secretion system
FY146_RS28420	COG3451	type IV secretory pathway VirB4
FY146_RS28435	COG4962	Type ii secretion system protein e