locus-tag	class	description
FY148_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY148_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY148_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY148_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY148_RS00025	COG1420	regulation of RNA biosynthetic process
FY148_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY148_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY148_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY148_RS00050	COG1137	ATPase activity
FY148_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY148_RS00065	COG0616	signal peptide processing
FY148_RS00070	COG0776	regulation of translation
FY148_RS00080	COG0116	Belongs to the methyltransferase superfamily
FY148_RS00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY148_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY148_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY148_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY148_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY148_RS00115	COG0728	peptidoglycan biosynthetic process
FY148_RS00125	COG0180	Tryptophanyl-tRNA synthetase
FY148_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY148_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
FY148_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY148_RS00165	COG1702	phosphate starvation-inducible protein PhoH
FY148_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY148_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY148_RS00185	COG1396	sequence-specific DNA binding
FY148_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY148_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY148_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS00210	COG0242	peptide deformylase activity
FY148_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY148_RS00220	COG0101	tRNA pseudouridine synthase activity
FY148_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY148_RS00235	COG2171	N-acyltransferase activity
FY148_RS00245	COG0840	transmembrane signaling receptor activity
FY148_RS00250	COG1957	nucleoside hydrolase
FY148_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY148_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY148_RS00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY148_RS00295	COG0706	membrane insertase activity
FY148_RS00300	COG0594	ribonuclease P activity
FY148_RS00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY148_RS00310	COG0840	transmembrane signaling receptor activity
FY148_RS00325	COG2226	methyltransferase
FY148_RS00330	COG3842	ATPase activity
FY148_RS00335	COG1175	transmembrane transport
FY148_RS00340	COG0395	ABC-type sugar transport system, permease component
FY148_RS00355	COG0427	acetyl-CoA hydrolase
FY148_RS00365	COG3938	Belongs to the proline racemase family
FY148_RS00370	COG0418	dihydroorotase activity
FY148_RS00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY148_RS00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY148_RS00400	COG0166	Belongs to the GPI family
FY148_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
FY148_RS00410	COG3842	ATPase activity
FY148_RS00415	COG1840	ABC-type Fe3 transport system, periplasmic component
FY148_RS00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY148_RS00425	COG4774	siderophore transport
FY148_RS00470	COG2326	polyphosphate kinase activity
FY148_RS00475	COG5002	protein histidine kinase activity
FY148_RS00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY148_RS00485	COG0573	inorganic phosphate transmembrane transporter activity
FY148_RS00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY148_RS00500	COG0704	Plays a role in the regulation of phosphate uptake
FY148_RS00505	COG0745	RESPONSE REGULATOR receiver
FY148_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY148_RS00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY148_RS00530	COG2967	ApaG domain
FY148_RS00540	COG0717	Belongs to the dCTP deaminase family
FY148_RS00550	COG0582	viral genome integration into host DNA
FY148_RS00575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY148_RS00620	COG1396	sequence-specific DNA binding
FY148_RS00635	COG1132	(ABC) transporter
FY148_RS00670	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FY148_RS00675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY148_RS00725	COG0167	dihydroorotate dehydrogenase activity
FY148_RS00740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY148_RS00760	COG1959	2 iron, 2 sulfur cluster binding
FY148_RS00765	COG1201	RNA secondary structure unwinding
FY148_RS00795	COG1960	acyl-CoA dehydrogenase activity
FY148_RS00800	COG0183	Belongs to the thiolase family
FY148_RS00805	COG1024	Enoyl-CoA hydratase
FY148_RS00805	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY148_RS00825	COG1320	monovalent cation:proton antiporter activity
FY148_RS00830	COG2212	antiporter activity
FY148_RS00835	COG1863	multisubunit Na H antiporter MnhE subunit
FY148_RS00840	COG0651	ATP synthesis coupled electron transport
FY148_RS00845	COG1006	Multisubunit Na H antiporter MnhC subunit
FY148_RS00850	COG2111	Na H antiporter
FY148_RS00850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY148_RS00860	COG0840	transmembrane signaling receptor activity
FY148_RS00870	COG0745	RESPONSE REGULATOR receiver
FY148_RS00875	COG0643	Histidine kinase
FY148_RS00875	COG2198	Histidine kinase
FY148_RS00880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY148_RS00885	COG2201	protein-glutamate methylesterase activity
FY148_RS00890	COG0745	RESPONSE REGULATOR receiver
FY148_RS00895	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY148_RS00905	COG1766	The M ring may be actively involved in energy transduction
FY148_RS00910	COG2771	luxR family
FY148_RS00920	COG0840	transmembrane signaling receptor activity
FY148_RS00920	COG2972	Histidine kinase
FY148_RS00925	COG0784	Response regulator, receiver
FY148_RS00925	COG2198	Histidine kinase
FY148_RS00925	COG2205	protein histidine kinase activity
FY148_RS00930	COG1970	mechanosensitive ion channel activity
FY148_RS00935	COG0436	Aminotransferase
FY148_RS00950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY148_RS00955	COG0424	maF-like protein
FY148_RS00960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY148_RS00970	COG5328	Belongs to the UPF0262 family
FY148_RS00975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY148_RS00985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY148_RS01005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY148_RS01015	COG1338	Plays a role in the flagellum-specific transport system
FY148_RS01025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY148_RS01035	COG1706	bacterial-type flagellum-dependent cell motility
FY148_RS01040	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY148_RS01045	COG4786	Flagellar basal body rod
FY148_RS01050	COG1677	Flagellar hook-basal body complex protein FliE
FY148_RS01055	COG1558	bacterial-type flagellum-dependent cell motility
FY148_RS01060	COG1815	bacterial-type flagellum-dependent cell motility
FY148_RS01070	COG1157	protein secretion by the type III secretion system
FY148_RS01075	COG4786	Flagellar basal body rod
FY148_RS01085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY148_RS01090	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY148_RS01095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY148_RS01100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY148_RS01105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY148_RS01125	COG1360	Flagellar Motor Protein
FY148_RS01150	COG1749	Flagellar hook protein flgE
FY148_RS01170	COG5443	negative regulation of bacterial-type flagellum assembly
FY148_RS01175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY148_RS01185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY148_RS01225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY148_RS01230	COG1609	Transcriptional regulator
FY148_RS01235	COG1653	transport
FY148_RS01240	COG1175	transmembrane transport
FY148_RS01245	COG0395	ABC-type sugar transport system, permease component
FY148_RS01250	COG0366	Alpha amylase catalytic
FY148_RS01255	COG3842	ATPase activity
FY148_RS01270	COG0129	dihydroxy-acid dehydratase activity
FY148_RS01275	COG0363	glucosamine-6-phosphate deaminase activity
FY148_RS01280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY148_RS01290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS01300	COG2081	HI0933 family
FY148_RS01320	COG2224	Isocitrate lyase
FY148_RS01335	COG3842	ATPase activity
FY148_RS01340	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS01345	COG1177	transmembrane transport
FY148_RS01355	COG2205	protein histidine kinase activity
FY148_RS01365	COG0248	Ppx GppA phosphatase
FY148_RS01370	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY148_RS01375	COG0477	Major facilitator Superfamily
FY148_RS01405	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY148_RS01410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY148_RS01420	COG0142	geranyltranstransferase activity
FY148_RS01445	COG0752	glycyl-tRNA synthetase alpha subunit
FY148_RS01455	COG1704	LemA family
FY148_RS01460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY148_RS01470	COG0751	glycine-tRNA ligase activity
FY148_RS01475	COG1683	Conserved Protein
FY148_RS01480	COG0840	transmembrane signaling receptor activity
FY148_RS01490	COG0151	Belongs to the GarS family
FY148_RS01495	COG2183	response to ionizing radiation
FY148_RS01500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY148_RS01510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FY148_RS01525	COG0583	DNA-binding transcription factor activity
FY148_RS01545	COG0306	phosphate transporter
FY148_RS01555	COG0561	phosphatase activity
FY148_RS01560	COG0438	transferase activity, transferring glycosyl groups
FY148_RS01565	COG2186	Transcriptional regulator
FY148_RS01580	COG0583	DNA-binding transcription factor activity
FY148_RS01585	COG0277	FAD linked oxidase domain protein
FY148_RS01590	COG0277	FAD linked oxidase domain protein
FY148_RS01595	COG0247	lactate metabolic process
FY148_RS01605	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS01610	COG2818	Glycosylase
FY148_RS01620	COG2855	membrane
FY148_RS01625	COG0583	DNA-binding transcription factor activity
FY148_RS01655	COG0124	histidyl-tRNA synthetase
FY148_RS01665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY148_RS01670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY148_RS01675	COG2259	Doxx family
FY148_RS01685	COG0459	protein refolding
FY148_RS01690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY148_RS01700	COG0196	riboflavin kinase activity
FY148_RS01705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY148_RS01715	COG0590	tRNA wobble adenosine to inosine editing
FY148_RS01720	COG1187	pseudouridine synthase activity
FY148_RS01725	COG0742	ribosomal rna small subunit methyltransferase
FY148_RS01730	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY148_RS01740	COG0312	modulator of DNA gyrase
FY148_RS01745	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS01755	COG1519	Transferase
FY148_RS01765	COG1663	tetraacyldisaccharide 4'-kinase activity
FY148_RS01775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY148_RS01780	COG0745	RESPONSE REGULATOR receiver
FY148_RS01785	COG5001	Diguanylate cyclase
FY148_RS01785	COG3300	MHYT domain
FY148_RS01790	COG3386	PFAM SMP-30 Gluconolaconase
FY148_RS01795	COG0800	Aldolase
FY148_RS01800	COG3734	2-keto-3-deoxy-galactonokinase
FY148_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS01810	COG1414	Transcriptional regulator
FY148_RS01815	COG2197	response regulator
FY148_RS01830	COG0598	Magnesium transport protein CorA
FY148_RS01835	COG3158	transport of potassium into the cell
FY148_RS01850	COG0356	it plays a direct role in the translocation of protons across the membrane
FY148_RS01860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY148_RS01865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY148_RS01880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY148_RS01900	COG0009	L-threonylcarbamoyladenylate synthase
FY148_RS01910	COG4638	Rieske (2fe-2S)
FY148_RS01935	COG1960	acyl-CoA dehydrogenase activity
FY148_RS01950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY148_RS01955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY148_RS01960	COG0840	transmembrane signaling receptor activity
FY148_RS01970	COG1522	sequence-specific DNA binding
FY148_RS01995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY148_RS02000	COG1741	Belongs to the pirin family
FY148_RS02005	COG1722	exodeoxyribonuclease VII activity
FY148_RS02010	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY148_RS02015	COG1268	BioY protein
FY148_RS02020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY148_RS02025	COG1122	ATPase activity
FY148_RS02030	COG3214	Protein conserved in bacteria
FY148_RS02035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY148_RS02035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY148_RS02040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY148_RS02055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY148_RS02070	COG0259	pyridoxamine-phosphate oxidase activity
FY148_RS02100	COG0312	modulator of DNA gyrase
FY148_RS02115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY148_RS02120	COG0109	protoheme IX farnesyltransferase activity
FY148_RS02130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY148_RS02145	COG3346	SURF1 family
FY148_RS02150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY148_RS02155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY148_RS02160	COG0328	RNA-DNA hybrid ribonuclease activity
FY148_RS02170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY148_RS02170	COG0678	peroxiredoxin activity
FY148_RS02180	COG1678	Uncharacterized ACR, COG1678
FY148_RS02185	COG3237	CsbD-like
FY148_RS02195	COG5001	Diguanylate cyclase
FY148_RS02195	COG3300	MHYT domain
FY148_RS02200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY148_RS02205	COG0612	Peptidase, M16
FY148_RS02230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY148_RS02235	COG1802	Transcriptional regulator
FY148_RS02250	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY148_RS02255	COG3609	addiction module antidote protein, CC2985 family
FY148_RS02260	COG3668	Plasmid stabilization system
FY148_RS02270	COG1194	a g-specific adenine glycosylase
FY148_RS02285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY148_RS02290	COG1196	nuclear chromosome segregation
FY148_RS02295	COG2514	catechol 2,3-dioxygenase activity
FY148_RS02300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY148_RS02300	COG0574	Belongs to the PEP-utilizing enzyme family
FY148_RS02315	COG1823	symporter activity
FY148_RS02345	COG0579	oxidoreductase
FY148_RS02360	COG2895	sulfate adenylyltransferase (ATP) activity
FY148_RS02365	COG0175	sulfate reduction
FY148_RS02370	COG0175	sulfate reduction
FY148_RS02375	COG1959	2 iron, 2 sulfur cluster binding
FY148_RS02380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY148_RS02385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY148_RS02390	COG4208	sulfate ABC transporter
FY148_RS02395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY148_RS02405	COG2203	Gaf domain
FY148_RS02405	COG2200	EAL domain
FY148_RS02405	COG2199	diguanylate cyclase activity
FY148_RS02415	COG1309	transcriptional regulator
FY148_RS02420	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS02425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY148_RS02455	COG0625	glutathione transferase activity
FY148_RS02465	COG0477	Major facilitator Superfamily
FY148_RS02475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY148_RS02475	COG1793	dna ligase
FY148_RS02495	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS02500	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS02505	COG1846	Transcriptional regulator
FY148_RS02510	COG1764	response to oxidative stress
FY148_RS02525	COG0488	(ABC) transporter
FY148_RS02560	COG4221	oxidoreductase activity
FY148_RS02575	COG0433	COG0433 Predicted ATPase
FY148_RS02585	COG1733	regulation of RNA biosynthetic process
FY148_RS02590	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY148_RS02605	COG0656	L-ascorbic acid biosynthetic process
FY148_RS02610	COG3781	membrane
FY148_RS02615	COG2378	regulation of single-species biofilm formation
FY148_RS02625	COG4106	trans-aconitate 2-methyltransferase activity
FY148_RS02630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY148_RS02635	COG0840	transmembrane signaling receptor activity
FY148_RS02640	COG0583	DNA-binding transcription factor activity
FY148_RS02655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY148_RS02675	COG3909	cytochrome
FY148_RS02680	COG2010	Cytochrome c
FY148_RS02710	COG0789	Transcriptional regulator
FY148_RS02735	COG0517	IMP dehydrogenase activity
FY148_RS02735	COG4175	Glycine betaine
FY148_RS02740	COG4176	ABC-type proline glycine betaine transport system permease component
FY148_RS02765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS02775	COG2169	Transcriptional regulator
FY148_RS02775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY148_RS02785	COG2514	catechol 2,3-dioxygenase activity
FY148_RS02805	COG1272	protein, Hemolysin III
FY148_RS02815	COG1280	lysine exporter protein (LysE YggA)
FY148_RS02820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY148_RS02825	COG2111	Na H antiporter
FY148_RS02825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY148_RS02830	COG2111	Na H antiporter
FY148_RS02835	COG1006	Multisubunit Na H antiporter MnhC subunit
FY148_RS02840	COG0651	ATP synthesis coupled electron transport
FY148_RS02845	COG1863	multisubunit Na H antiporter MnhE subunit
FY148_RS02850	COG2212	antiporter activity
FY148_RS02855	COG1320	monovalent cation:proton antiporter activity
FY148_RS02860	COG4957	zinc ion binding
FY148_RS02875	COG2166	iron-sulfur cluster assembly
FY148_RS02885	COG2205	protein histidine kinase activity
FY148_RS02930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY148_RS02935	COG2983	Belongs to the UPF0260 family
FY148_RS02945	COG3041	Addiction module toxin RelE StbE family
FY148_RS02950	COG3077	Addiction module antitoxin, RelB DinJ family
FY148_RS02990	COG2814	Major facilitator Superfamily
FY148_RS03000	COG1621	beta-fructofuranosidase activity
FY148_RS03005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY148_RS03055	COG4695	Portal protein
FY148_RS03160	COG4235	cytochrome complex assembly
FY148_RS03165	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY148_RS03170	COG1138	Cytochrome C-type biogenesis protein
FY148_RS03175	COG3088	subunit of a heme lyase
FY148_RS03180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY148_RS03185	COG0745	RESPONSE REGULATOR receiver
FY148_RS03195	COG3011	Protein conserved in bacteria
FY148_RS03200	COG3713	MltA-interacting MipA family protein
FY148_RS03205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY148_RS03210	COG2202	Pas domain
FY148_RS03210	COG2205	protein histidine kinase activity
FY148_RS03220	COG0308	aminopeptidase N
FY148_RS03225	COG0697	spore germination
FY148_RS03240	COG0443	Heat shock 70 kDa protein
FY148_RS03275	COG0604	alcohol dehydrogenase
FY148_RS03280	COG1733	regulation of RNA biosynthetic process
FY148_RS03285	COG1968	undecaprenyl-diphosphatase activity
FY148_RS03290	COG2239	Acts as a magnesium transporter
FY148_RS03295	COG2814	Major facilitator Superfamily
FY148_RS03320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY148_RS03350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY148_RS03395	COG0741	lytic transglycosylase activity
FY148_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS03405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY148_RS03410	COG0840	transmembrane signaling receptor activity
FY148_RS03420	COG1758	RNA polymerase activity
FY148_RS03445	COG0736	holo-[acyl-carrier-protein] synthase activity
FY148_RS03450	COG0681	Belongs to the peptidase S26 family
FY148_RS03455	COG0571	ribonuclease III activity
FY148_RS03460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY148_RS03470	COG0784	Response regulator, receiver
FY148_RS03475	COG1381	Involved in DNA repair and RecF pathway recombination
FY148_RS03485	COG2226	methyltransferase
FY148_RS03495	COG1418	mRNA catabolic process
FY148_RS03505	COG0346	lactoylglutathione lyase activity
FY148_RS03520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS03525	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY148_RS03530	COG0668	transmembrane transport
FY148_RS03540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY148_RS03570	COG1742	UPF0060 membrane protein
FY148_RS03590	COG1183	phosphatidylcholine synthase activity
FY148_RS03595	COG0688	phosphatidylethanolamine metabolic process
FY148_RS03600	COG5265	(ABC) transporter
FY148_RS03640	COG2852	Protein conserved in bacteria
FY148_RS03645	COG0215	cysteine-tRNA ligase activity
FY148_RS03650	COG4221	oxidoreductase activity
FY148_RS03655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY148_RS03660	COG1286	toxin biosynthetic process
FY148_RS03680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY148_RS03690	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY148_RS03700	COG0305	Participates in initiation and elongation during chromosome replication
FY148_RS03720	COG0359	binds to the 23S rRNA
FY148_RS03730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY148_RS03735	COG0360	Binds together with S18 to 16S ribosomal RNA
FY148_RS03745	COG0667	Aldo Keto reductase
FY148_RS03750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY148_RS03760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY148_RS03765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY148_RS03775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY148_RS03780	COG1561	YicC-like family, N-terminal region
FY148_RS03785	COG0194	GDP metabolic process
FY148_RS03800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY148_RS03805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY148_RS03815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY148_RS03830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY148_RS03850	COG5001	Diguanylate cyclase
FY148_RS03850	COG2203	Gaf domain
FY148_RS03850	COG3706	GGDEF domain
FY148_RS03850	COG4251	negative regulation of phosphorylation
FY148_RS03855	COG5001	Diguanylate cyclase
FY148_RS03855	COG3300	MHYT domain
FY148_RS03860	COG4191	Histidine kinase
FY148_RS03865	COG4566	intracellular signal transduction
FY148_RS03875	COG0488	(ABC) transporter
FY148_RS03880	COG3706	GGDEF domain
FY148_RS03890	COG0105	UTP biosynthetic process
FY148_RS03910	COG0314	molybdopterin synthase activity
FY148_RS03920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY148_RS03925	COG0322	excinuclease ABC activity
FY148_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS03955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY148_RS03960	COG0243	molybdopterin cofactor binding
FY148_RS03985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY148_RS03990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY148_RS03995	COG2226	methyltransferase
FY148_RS04000	COG0628	permease
FY148_RS04010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY148_RS04015	COG0248	Ppx GppA phosphatase
FY148_RS04040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY148_RS04050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY148_RS04055	COG0477	Major facilitator Superfamily
FY148_RS04060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY148_RS04070	COG0840	transmembrane signaling receptor activity
FY148_RS04075	COG0659	secondary active sulfate transmembrane transporter activity
FY148_RS04085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY148_RS04090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY148_RS04100	COG0113	porphobilinogen synthase activity
FY148_RS04120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY148_RS04125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY148_RS04130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY148_RS04130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY148_RS04140	COG1280	lysine exporter protein (LysE YggA)
FY148_RS04145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY148_RS04150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY148_RS04155	COG2814	Major facilitator Superfamily
FY148_RS04160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY148_RS04180	COG0416	fatty acid biosynthetic process
FY148_RS04185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY148_RS04190	COG0776	regulation of translation
FY148_RS04225	COG0601	transmembrane transport
FY148_RS04230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS04235	COG0444	Belongs to the ABC transporter superfamily
FY148_RS04245	COG0747	negative chemotaxis
FY148_RS04255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY148_RS04260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY148_RS04275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY148_RS04280	COG0583	DNA-binding transcription factor activity
FY148_RS04285	COG0737	Belongs to the 5'-nucleotidase family
FY148_RS04305	COG2897	thiosulfate sulfurtransferase activity
FY148_RS04320	COG0415	Belongs to the DNA photolyase family
FY148_RS04330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY148_RS04360	COG3932	Exopolysaccharide synthesis, ExoD
FY148_RS04365	COG1238	metal cluster binding
FY148_RS04440	COG1612	heme a metabolic process
FY148_RS04450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY148_RS04455	COG0010	Belongs to the arginase family
FY148_RS04460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY148_RS04465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY148_RS04475	COG1832	CoA-binding protein
FY148_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS04505	COG2124	cytochrome p450
FY148_RS04510	COG2199	diguanylate cyclase activity
FY148_RS04515	COG0740	serine-type endopeptidase activity
FY148_RS04520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY148_RS04525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY148_RS04535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY148_RS04565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY148_RS04570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY148_RS04575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY148_RS04585	COG0649	NAD binding
FY148_RS04595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY148_RS04600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY148_RS04610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY148_RS04615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY148_RS04625	COG0713	ATP synthesis coupled electron transport
FY148_RS04640	COG1007	ATP synthesis coupled electron transport
FY148_RS04645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY148_RS04645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY148_RS04660	COG0442	prolyl-tRNA aminoacylation
FY148_RS04670	COG1136	(ABC) transporter
FY148_RS04685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY148_RS04705	COG0784	Response regulator, receiver
FY148_RS04715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY148_RS04720	COG0477	Major facilitator Superfamily
FY148_RS04735	COG0557	exoribonuclease II activity
FY148_RS04740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY148_RS04750	COG0758	DNA mediated transformation
FY148_RS04755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY148_RS04765	COG0540	Belongs to the ATCase OTCase family
FY148_RS04780	COG1960	acyl-CoA dehydrogenase activity
FY148_RS04785	COG0456	acetyltransferase
FY148_RS04805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY148_RS04810	COG2824	Alkylphosphonate utilization operon protein PhnA
FY148_RS04815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY148_RS04820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY148_RS04825	COG0154	amidase activity
FY148_RS04830	COG0456	acetyltransferase
FY148_RS04835	COG3811	Belongs to the UPF0386 family
FY148_RS04850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY148_RS04860	COG0456	acetyltransferase
FY148_RS04880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY148_RS04885	COG0439	Biotin carboxylase
FY148_RS04890	COG0511	ligase activity, forming carbon-carbon bonds
FY148_RS04895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY148_RS04905	COG0436	Aminotransferase
FY148_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS04930	COG1530	ribonuclease E activity
FY148_RS04940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY148_RS04960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY148_RS04965	COG0384	phenazine biosynthesis protein PhzF
FY148_RS04985	COG0633	Ferredoxin
FY148_RS04995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY148_RS05000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY148_RS05005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY148_RS05015	COG3768	UPF0283 membrane protein
FY148_RS05020	COG3106	COG3106 Predicted ATPase
FY148_RS05050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY148_RS05085	COG0537	adenosine 5'-monophosphoramidase activity
FY148_RS05110	COG0052	Belongs to the universal ribosomal protein uS2 family
FY148_RS05115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY148_RS05120	COG0528	UMP kinase activity
FY148_RS05125	COG0233	cytoplasmic translational termination
FY148_RS05130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY148_RS05140	COG0750	zinc metalloprotease
FY148_RS05145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY148_RS05150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY148_RS05155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY148_RS05160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY148_RS05165	COG3494	Protein of unknown function (DUF1009)
FY148_RS05170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY148_RS05175	COG2186	Transcriptional regulator
FY148_RS05185	COG0765	amino acid transport
FY148_RS05190	COG0765	amino acid transport
FY148_RS05200	COG0372	Belongs to the citrate synthase family
FY148_RS05215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY148_RS05225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY148_RS05230	COG0148	phosphopyruvate hydratase activity
FY148_RS05240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY148_RS05245	COG0022	dehydrogenase e1 component
FY148_RS05245	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY148_RS05250	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY148_RS05260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY148_RS05270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY148_RS05275	COG0697	spore germination
FY148_RS05295	COG2867	negative regulation of translational initiation
FY148_RS05300	COG1546	Belongs to the CinA family
FY148_RS05300	COG1058	Belongs to the CinA family
FY148_RS05305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY148_RS05305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY148_RS05315	COG3852	Histidine kinase
FY148_RS05320	COG2204	response regulator
FY148_RS05325	COG5000	phosphorelay sensor kinase activity
FY148_RS05330	COG2204	response regulator
FY148_RS05335	COG0569	domain protein
FY148_RS05340	COG1923	regulation of RNA biosynthetic process
FY148_RS05345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY148_RS05350	COG3956	TIGRFAM MazG family protein
FY148_RS05360	COG1648	precorrin-2 dehydrogenase activity
FY148_RS05360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY148_RS05400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY148_RS05400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY148_RS05405	COG0509	glycine decarboxylation via glycine cleavage system
FY148_RS05410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY148_RS05435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY148_RS05440	COG0564	pseudouridine synthase activity
FY148_RS05460	COG0251	oxidation-reduction process
FY148_RS05465	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY148_RS05475	COG1671	Belongs to the UPF0178 family
FY148_RS05490	COG0450	alkyl hydroperoxide reductase
FY148_RS05495	COG0625	glutathione transferase activity
FY148_RS05515	COG0431	NADPH-dependent FMN reductase
FY148_RS05525	COG0798	PFAM Bile acid sodium symporter
FY148_RS05530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY148_RS05545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY148_RS05545	COG0321	lipoyl(octanoyl) transferase activity
FY148_RS05550	COG0084	hydrolase, TatD family'
FY148_RS05555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY148_RS05565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY148_RS05625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY148_RS05630	COG2095	MarC family integral membrane protein
FY148_RS05635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY148_RS05635	COG0617	tRNA 3'-terminal CCA addition
FY148_RS05635	COG0517	IMP dehydrogenase activity
FY148_RS05645	COG0629	single-stranded DNA binding
FY148_RS05650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY148_RS05660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY148_RS05665	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY148_RS05680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY148_RS05685	COG1121	(ABC) transporter
FY148_RS05705	COG0667	Aldo Keto reductase
FY148_RS05715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY148_RS05795	COG2239	Acts as a magnesium transporter
FY148_RS05800	COG0243	molybdopterin cofactor binding
FY148_RS05810	COG0242	peptide deformylase activity
FY148_RS05825	COG2205	protein histidine kinase activity
FY148_RS05825	COG2202	Pas domain
FY148_RS05835	COG0321	lipoyl(octanoyl) transferase activity
FY148_RS05840	COG1064	alcohol dehydrogenase
FY148_RS05870	COG1862	Preprotein translocase
FY148_RS05890	COG2124	cytochrome p450
FY148_RS05905	COG0596	Alpha beta hydrolase
FY148_RS05920	COG0626	cystathionine gamma-synthase activity
FY148_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS05930	COG4597	amino acid ABC transporter
FY148_RS05935	COG0765	amino acid transport
FY148_RS05940	COG1126	abc transporter atp-binding protein
FY148_RS05950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY148_RS05965	COG0436	Aminotransferase
FY148_RS05995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY148_RS06005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY148_RS06010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY148_RS06015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY148_RS06030	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY148_RS06035	COG1489	DNA binding
FY148_RS06040	COG0024	Methionine aminopeptidase
FY148_RS06045	COG2003	Belongs to the UPF0758 family
FY148_RS06060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY148_RS06085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY148_RS06090	COG0546	phosphoglycolate phosphatase activity
FY148_RS06100	COG0114	fumarate hydratase activity
FY148_RS06110	COG0504	CTP synthase activity
FY148_RS06120	COG0149	triose-phosphate isomerase activity
FY148_RS06130	COG0187	DNA topoisomerase II activity
FY148_RS06140	COG0740	serine-type endopeptidase activity
FY148_RS06150	COG0640	Transcriptional regulator
FY148_RS06155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY148_RS06160	COG0745	RESPONSE REGULATOR receiver
FY148_RS06175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY148_RS06175	COG3264	Mechanosensitive ion channel
FY148_RS06245	COG1127	ABC transporter
FY148_RS06250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY148_RS06255	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS06265	COG0280	phosphate acetyltransferase
FY148_RS06265	COG0281	malic enzyme
FY148_RS06275	COG0778	Nitroreductase
FY148_RS06280	COG0823	Involved in the tonB-independent uptake of proteins
FY148_RS06295	COG1368	sulfuric ester hydrolase activity
FY148_RS06315	COG3265	gluconokinase activity
FY148_RS06320	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY148_RS06340	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY148_RS06360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY148_RS06375	COG0318	PFAM AMP-dependent synthetase and ligase
FY148_RS06385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY148_RS06385	COG0512	Glutamine amidotransferase of anthranilate synthase
FY148_RS06390	COG0343	queuine tRNA-ribosyltransferase activity
FY148_RS06395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY148_RS06410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY148_RS06430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY148_RS06435	COG0134	indole-3-glycerol-phosphate synthase activity
FY148_RS06440	COG0315	cyclic pyranopterin monophosphate synthase activity
FY148_RS06445	COG0303	'Molybdopterin
FY148_RS06450	COG3706	GGDEF domain
FY148_RS06460	COG0475	glutathione-regulated potassium exporter activity
FY148_RS06460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY148_RS06470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY148_RS06480	COG2814	Major facilitator Superfamily
FY148_RS06485	COG0746	molybdenum cofactor guanylyltransferase activity
FY148_RS06490	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY148_RS06495	COG0739	heme binding
FY148_RS06500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY148_RS06505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY148_RS06510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY148_RS06515	COG0805	protein transport
FY148_RS06520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY148_RS06525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY148_RS06530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY148_RS06535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY148_RS06540	COG1472	Belongs to the glycosyl hydrolase 3 family
FY148_RS06550	COG0018	arginyl-trna synthetase
FY148_RS06555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY148_RS06580	COG0525	valine-tRNA ligase activity
FY148_RS06590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY148_RS06830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY148_RS06840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FY148_RS07045	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY148_RS07050	COG1546	Belongs to the CinA family
FY148_RS07050	COG1058	Belongs to the CinA family
FY148_RS07055	COG0589	response to stress
FY148_RS07060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY148_RS07075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY148_RS07135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY148_RS07155	COG2815	serine threonine protein kinase
FY148_RS07155	COG0515	serine threonine protein kinase
FY148_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS07180	COG0583	DNA-binding transcription factor activity
FY148_RS07185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY148_RS07250	COG0640	Transcriptional regulator
FY148_RS07255	COG1914	H( )-stimulated, divalent metal cation uptake system
FY148_RS07265	COG1132	(ABC) transporter
FY148_RS07270	COG0628	permease
FY148_RS07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY148_RS07315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY148_RS07325	COG0302	gtp cyclohydrolase
FY148_RS07330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY148_RS07335	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY148_RS07345	COG0517	IMP dehydrogenase activity
FY148_RS07345	COG0516	GMP reductase activity
FY148_RS07380	COG1760	l-serine dehydratase
FY148_RS07420	COG0583	DNA-binding transcription factor activity
FY148_RS07435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY148_RS07435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY148_RS07445	COG0347	Belongs to the P(II) protein family
FY148_RS07450	COG0174	glutamine synthetase
FY148_RS07480	COG0697	spore germination
FY148_RS07490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY148_RS07500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY148_RS07530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY148_RS07535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY148_RS07540	COG2186	Transcriptional regulator
FY148_RS07550	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY148_RS07555	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY148_RS07560	COG3845	ABC transporter
FY148_RS07565	COG1183	phosphatidylcholine synthase activity
FY148_RS07570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY148_RS07575	COG0679	Auxin Efflux Carrier
FY148_RS07580	COG0785	Cytochrome C biogenesis protein
FY148_RS07600	COG1278	Cold shock
FY148_RS07655	COG0577	efflux transmembrane transporter activity
FY148_RS07655	COG1136	(ABC) transporter
FY148_RS07660	COG0577	efflux transmembrane transporter activity
FY148_RS07660	COG1136	(ABC) transporter
FY148_RS07685	COG2151	metal-sulfur cluster biosynthetic enzyme
FY148_RS07690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY148_RS07695	COG0719	Fe-S assembly protein
FY148_RS07700	COG0396	ATPase activity
FY148_RS07705	COG0719	Fe-S assembly protein
FY148_RS07710	COG1104	cysteine desulfurase activity
FY148_RS07715	COG2945	thiolester hydrolase activity
FY148_RS07720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY148_RS07725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY148_RS07735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY148_RS07740	COG2833	Protein of unknown function (DUF455)
FY148_RS07745	COG0739	heme binding
FY148_RS07750	COG0513	Belongs to the DEAD box helicase family
FY148_RS07775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY148_RS07785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY148_RS07790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY148_RS07795	COG0047	phosphoribosylformylglycinamidine synthase activity
FY148_RS07810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY148_RS07815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY148_RS07835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY148_RS07840	COG2814	Major facilitator Superfamily
FY148_RS07980	COG4373	Mu-like prophage FluMu protein gp28
FY148_RS07985	COG4383	Mu-like prophage protein gp29
FY148_RS08010	COG4397	Mu-like prophage major head subunit gpT
FY148_RS08030	COG4387	Mu-like prophage protein GP36
FY148_RS08085	COG3299	homolog of phage Mu protein gp47
FY148_RS08115	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS08120	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS08125	COG0037	tRNA processing
FY148_RS08130	COG2066	Belongs to the glutaminase family
FY148_RS08135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY148_RS08140	COG0861	Integral membrane protein TerC family
FY148_RS08155	COG1280	lysine exporter protein (LysE YggA)
FY148_RS08165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY148_RS08170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY148_RS08180	COG0538	isocitrate dehydrogenase activity
FY148_RS08190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY148_RS08195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY148_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS08205	COG2313	pseudouridylate synthase activity
FY148_RS08215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS08220	COG4215	(ABC) transporter
FY148_RS08230	COG5425	PFAM Usg family protein
FY148_RS08240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY148_RS08245	COG1522	sequence-specific DNA binding
FY148_RS08250	COG1573	uracil-dna glycosylase
FY148_RS08260	COG2202	Pas domain
FY148_RS08260	COG2205	protein histidine kinase activity
FY148_RS08270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY148_RS08275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY148_RS08290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY148_RS08295	COG0842	Transport permease protein
FY148_RS08300	COG1131	(ABC) transporter
FY148_RS08305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY148_RS08305	COG0730	response to heat
FY148_RS08325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY148_RS08330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY148_RS08350	COG0129	dihydroxy-acid dehydratase activity
FY148_RS08355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY148_RS08360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY148_RS08370	COG3739	integral membrane protein
FY148_RS08380	COG0203	ribosomal protein L17
FY148_RS08385	COG0202	RNA polymerase activity
FY148_RS08390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY148_RS08395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY148_RS08400	COG0563	adenylate kinase activity
FY148_RS08405	COG0201	protein transport
FY148_RS08410	COG0200	Binds to the 23S rRNA
FY148_RS08415	COG1841	ribosomal large subunit assembly
FY148_RS08420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY148_RS08425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY148_RS08430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY148_RS08435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY148_RS08440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY148_RS08445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY148_RS08450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY148_RS08455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY148_RS08460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY148_RS08465	COG0255	Belongs to the universal ribosomal protein uL29 family
FY148_RS08470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY148_RS08475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY148_RS08480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY148_RS08485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY148_RS08490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY148_RS08495	COG0089	rRNA binding
FY148_RS08500	COG0088	Forms part of the polypeptide exit tunnel
FY148_RS08505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY148_RS08510	COG0051	transcription antitermination factor activity, RNA binding
FY148_RS08515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY148_RS08520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY148_RS08525	COG0049	tRNA binding
FY148_RS08530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY148_RS08550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY148_RS08555	COG0085	RNA polymerase activity
FY148_RS08560	COG0222	ribosome binding
FY148_RS08565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY148_RS08570	COG0081	regulation of translation
FY148_RS08575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY148_RS08585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY148_RS08595	COG1086	Polysaccharide biosynthesis protein
FY148_RS08600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY148_RS08605	COG0861	Integral membrane protein TerC family
FY148_RS08610	COG3895	Periplasmic Protein
FY148_RS08630	COG1132	(ABC) transporter
FY148_RS08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY148_RS08655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY148_RS08690	COG0784	Response regulator, receiver
FY148_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS08690	COG2198	Histidine kinase
FY148_RS08690	COG2205	protein histidine kinase activity
FY148_RS08695	COG0784	Response regulator, receiver
FY148_RS08700	COG2202	Pas domain
FY148_RS08700	COG3920	Histidine kinase
FY148_RS08705	COG0784	Response regulator, receiver
FY148_RS08710	COG4251	negative regulation of phosphorylation
FY148_RS08725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY148_RS08730	COG1607	acyl-coa hydrolase
FY148_RS08750	COG2910	NAD(P)H-binding
FY148_RS08755	COG1733	regulation of RNA biosynthetic process
FY148_RS08770	COG0556	nucleotide-excision repair
FY148_RS08780	COG2382	esterase
FY148_RS08800	COG0484	heat shock protein binding
FY148_RS08820	COG3706	GGDEF domain
FY148_RS08840	COG1840	ABC-type Fe3 transport system, periplasmic component
FY148_RS08845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY148_RS08860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY148_RS08870	COG2207	Transcriptional regulator
FY148_RS08875	COG1064	alcohol dehydrogenase
FY148_RS08880	COG1252	NADH dehydrogenase
FY148_RS08885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY148_RS08895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY148_RS08930	COG0656	L-ascorbic acid biosynthetic process
FY148_RS08945	COG0440	acetolactate synthase activity
FY148_RS08950	COG0028	Belongs to the TPP enzyme family
FY148_RS08965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY148_RS08970	COG0560	Phosphoserine phosphatase
FY148_RS08970	COG3830	Belongs to the UPF0237 family
FY148_RS08990	COG0330	HflC and HflK could
FY148_RS08995	COG0330	HflC and HflK could
FY148_RS09005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY148_RS09040	COG0277	FAD linked oxidase domain protein
FY148_RS09045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY148_RS09085	COG1335	isochorismatase
FY148_RS09115	COG2264	protein methyltransferase activity
FY148_RS09120	COG1999	signal sequence binding
FY148_RS09130	COG0835	chemotaxis
FY148_RS09140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY148_RS09145	COG0583	DNA-binding transcription factor activity
FY148_RS09155	COG1247	-acetyltransferase
FY148_RS09165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY148_RS09170	COG0497	DNA recombination
FY148_RS09175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY148_RS09185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY148_RS09190	COG0849	cell division
FY148_RS09195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY148_RS09200	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY148_RS09205	COG0477	Major facilitator Superfamily
FY148_RS09210	COG5001	Diguanylate cyclase
FY148_RS09215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY148_RS09220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY148_RS09225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY148_RS09235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY148_RS09240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY148_RS09250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY148_RS09265	COG0275	rRNA processing
FY148_RS09270	COG2001	Belongs to the MraZ family
FY148_RS09295	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY148_RS09325	COG4106	trans-aconitate 2-methyltransferase activity
FY148_RS09345	COG2226	methyltransferase
FY148_RS09355	COG2267	carboxylic ester hydrolase activity
FY148_RS09360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY148_RS09375	COG0251	oxidation-reduction process
FY148_RS09390	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS09395	COG2814	Major facilitator Superfamily
FY148_RS09425	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS09430	COG0174	glutamine synthetase
FY148_RS09435	COG0531	amino acid
FY148_RS09445	COG1737	Transcriptional regulator
FY148_RS09450	COG2182	Extracellular solute-binding protein
FY148_RS09465	COG3842	ATPase activity
FY148_RS09530	COG2968	Membrane
FY148_RS09540	COG0432	Pfam Uncharacterised protein family UPF0047
FY148_RS09555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY148_RS09560	COG0358	DNA primase activity
FY148_RS09580	COG0505	Belongs to the CarA family
FY148_RS09585	COG0534	Mate efflux family protein
FY148_RS09600	COG2321	neutral zinc metallopeptidase
FY148_RS09615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY148_RS09625	COG3706	GGDEF domain
FY148_RS09640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY148_RS09650	COG1522	sequence-specific DNA binding
FY148_RS09655	COG0492	ferredoxin-NADP+ reductase activity
FY148_RS09660	COG0583	DNA-binding transcription factor activity
FY148_RS09670	COG1902	pentaerythritol trinitrate reductase activity
FY148_RS09695	COG0387	Pfam Sodium calcium exchanger
FY148_RS09700	COG0436	Aminotransferase
FY148_RS09705	COG2200	EAL domain
FY148_RS09705	COG2199	diguanylate cyclase activity
FY148_RS09720	COG1278	Cold shock
FY148_RS09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY148_RS09735	COG1846	Transcriptional regulator
FY148_RS09740	COG0745	RESPONSE REGULATOR receiver
FY148_RS09750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY148_RS09770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY148_RS09780	COG1496	oxidoreductase activity
FY148_RS09795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY148_RS09805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FY148_RS09820	COG0840	transmembrane signaling receptor activity
FY148_RS09825	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS09830	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY148_RS09835	COG5001	Diguanylate cyclase
FY148_RS09835	COG3300	MHYT domain
FY148_RS09840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY148_RS09845	COG5001	Diguanylate cyclase
FY148_RS09855	COG0193	aminoacyl-tRNA hydrolase activity
FY148_RS09865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY148_RS09890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY148_RS09900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY148_RS09900	COG2857	Cytochrome c1
FY148_RS09920	COG1132	(ABC) transporter
FY148_RS09925	COG1132	(ABC) transporter
FY148_RS09935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY148_RS09950	COG0408	coproporphyrinogen oxidase activity
FY148_RS09965	COG0617	tRNA 3'-terminal CCA addition
FY148_RS09980	COG0714	Associated with various cellular activities
FY148_RS10000	COG0454	-acetyltransferase
FY148_RS10015	COG0477	Major facilitator Superfamily
FY148_RS10025	COG0435	Glutathione S-transferase
FY148_RS10030	COG0494	nUDIX hydrolase
FY148_RS10040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY148_RS10045	COG3135	benzoate transporter
FY148_RS10070	COG0740	serine-type endopeptidase activity
FY148_RS10085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY148_RS10090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY148_RS10115	COG4175	Glycine betaine
FY148_RS10135	COG1435	thymidine kinase activity
FY148_RS10160	COG4771	TonB-dependent receptor
FY148_RS10160	COG1629	transport
FY148_RS10170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY148_RS10170	COG0512	Glutamine amidotransferase of anthranilate synthase
FY148_RS10185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY148_RS10195	COG0366	Alpha amylase catalytic
FY148_RS10200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS10220	COG1160	GTP binding
FY148_RS10240	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY148_RS10250	COG0024	Methionine aminopeptidase
FY148_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS10280	COG0583	DNA-binding transcription factor activity
FY148_RS10295	COG0402	S-adenosylhomocysteine deaminase activity
FY148_RS10315	COG1309	transcriptional regulator
FY148_RS10320	COG1686	Belongs to the peptidase S11 family
FY148_RS10330	COG2351	hydroxyisourate hydrolase activity
FY148_RS10335	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY148_RS10350	COG3195	allantoin biosynthetic process
FY148_RS10350	COG3648	Uricase
FY148_RS10360	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY148_RS10370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS10370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY148_RS10380	COG0513	Belongs to the DEAD box helicase family
FY148_RS10390	COG2259	Doxx family
FY148_RS10395	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS10405	COG2308	Evidence 4 Homologs of previously reported genes of
FY148_RS10415	COG1305	Transglutaminase-like
FY148_RS10440	COG4214	carbohydrate transport
FY148_RS10450	COG4213	ABC transporter substrate-binding protein
FY148_RS10515	COG2948	multi-organism process
FY148_RS10525	COG3701	Conjugal transfer protein
FY148_RS10530	COG3846	protein secretion by the type IV secretion system
FY148_RS10545	COG3451	type IV secretory pathway VirB4
FY148_RS10555	COG3838	Conjugal transfer protein Trbc
FY148_RS10560	COG4962	Type ii secretion system protein e
FY148_RS10565	COG0583	DNA-binding transcription factor activity
FY148_RS10585	COG4172	Belongs to the ABC transporter superfamily
FY148_RS10595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS10610	COG0251	oxidation-reduction process
FY148_RS10615	COG1609	Transcriptional regulator
FY148_RS10650	COG1196	nuclear chromosome segregation
FY148_RS10650	COG0741	lytic transglycosylase activity
FY148_RS10650	COG0739	heme binding
FY148_RS10660	COG4959	Type IV secretory pathway protease TraF
FY148_RS10710	COG5489	Protein of unknown function (DUF736)
FY148_RS10750	COG4372	Transposase
FY148_RS10755	COG3436	PFAM IS66 Orf2 family protein
FY148_RS10760	COG2963	transposase activity
FY148_RS10795	COG2972	Histidine kinase
FY148_RS10795	COG0840	transmembrane signaling receptor activity
FY148_RS10810	COG0646	methionine synthase
FY148_RS10810	COG1410	methionine synthase
FY148_RS10855	COG1215	transferase activity, transferring glycosyl groups
FY148_RS10885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY148_RS10900	COG2346	COG2346, Truncated hemoglobins
FY148_RS10920	COG1309	transcriptional regulator
FY148_RS10935	COG0494	nUDIX hydrolase
FY148_RS10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS10950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS10980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY148_RS10985	COG0830	nickel cation binding
FY148_RS10990	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY148_RS11005	COG0804	urea catabolic process
FY148_RS11010	COG1442	glycosyl transferase family 8
FY148_RS11015	COG3755	Protein conserved in bacteria
FY148_RS11025	COG0832	Belongs to the urease beta subunit family
FY148_RS11030	COG3813	Protein conserved in bacteria
FY148_RS11035	COG0831	urea catabolic process
FY148_RS11040	COG0829	nickel cation binding
FY148_RS11065	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY148_RS11085	COG0174	glutamine synthetase
FY148_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS11095	COG5002	protein histidine kinase activity
FY148_RS11095	COG2198	Histidine kinase
FY148_RS11095	COG0784	Response regulator, receiver
FY148_RS11110	COG0726	polysaccharide deacetylase
FY148_RS11145	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY148_RS11220	COG0564	pseudouridine synthase activity
FY148_RS11230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY148_RS11240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY148_RS11265	COG0346	lactoylglutathione lyase activity
FY148_RS11275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY148_RS11285	COG2832	Protein of unknown function (DUF454)
FY148_RS11290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY148_RS11295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS11300	COG4558	Periplasmic binding protein
FY148_RS11310	COG3721	Heme iron utilization protein
FY148_RS11325	COG3655	Transcriptional regulator
FY148_RS11350	COG2205	protein histidine kinase activity
FY148_RS11395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS11400	COG4605	iron ion homeostasis
FY148_RS11405	COG4604	ABC transporter, ATP-binding protein
FY148_RS11410	COG0783	Belongs to the Dps family
FY148_RS11425	COG0840	transmembrane signaling receptor activity
FY148_RS11425	COG2972	Histidine kinase
FY148_RS11430	COG0656	L-ascorbic acid biosynthetic process
FY148_RS11435	COG2814	Major facilitator Superfamily
FY148_RS11445	COG0583	DNA-binding transcription factor activity
FY148_RS11450	COG0657	acetylesterase activity
FY148_RS11455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS11475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY148_RS11480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY148_RS11485	COG0288	reversible hydration of carbon dioxide
FY148_RS11495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY148_RS11515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY148_RS11520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY148_RS11525	COG0778	Nitroreductase
FY148_RS11530	COG2267	carboxylic ester hydrolase activity
FY148_RS11535	COG0251	oxidation-reduction process
FY148_RS11540	COG1335	isochorismatase
FY148_RS11545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS11555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS11570	COG1175	transmembrane transport
FY148_RS11575	COG0395	ABC-type sugar transport system, permease component
FY148_RS11580	COG3842	ATPase activity
FY148_RS11585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS11595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY148_RS11610	COG4608	Belongs to the ABC transporter superfamily
FY148_RS11615	COG0444	Belongs to the ABC transporter superfamily
FY148_RS11620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS11625	COG0601	transmembrane transport
FY148_RS11680	COG2159	amidohydrolase
FY148_RS11685	COG1960	acyl-CoA dehydrogenase activity
FY148_RS11715	COG0745	RESPONSE REGULATOR receiver
FY148_RS11725	COG1902	pentaerythritol trinitrate reductase activity
FY148_RS11725	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY148_RS11730	COG3842	ATPase activity
FY148_RS11740	COG1840	ABC-type Fe3 transport system, periplasmic component
FY148_RS11745	COG1840	ABC-type Fe3 transport system, periplasmic component
FY148_RS11750	COG0745	RESPONSE REGULATOR receiver
FY148_RS11760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY148_RS11765	COG0583	DNA-binding transcription factor activity
FY148_RS11770	COG1278	Cold shock
FY148_RS11805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY148_RS11810	COG1309	transcriptional regulator
FY148_RS11815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS11820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY148_RS11830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY148_RS11835	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY148_RS11855	COG0583	DNA-binding transcription factor activity
FY148_RS11860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS11865	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY148_RS11870	COG4149	molybdate abc transporter
FY148_RS11875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY148_RS11890	COG2022	thiamine diphosphate biosynthetic process
FY148_RS11905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY148_RS11910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY148_RS11920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY148_RS11940	COG1132	(ABC) transporter
FY148_RS11945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY148_RS11990	COG4166	transmembrane transport
FY148_RS11995	COG0601	transmembrane transport
FY148_RS12000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS12015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY148_RS12020	COG3142	Participates in the control of copper homeostasis
FY148_RS12025	COG2814	Major facilitator Superfamily
FY148_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS12045	COG1737	Transcriptional regulator
FY148_RS12055	COG3842	ATPase activity
FY148_RS12065	COG0395	ABC-type sugar transport system, permease component
FY148_RS12080	COG2188	Transcriptional regulator
FY148_RS12085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY148_RS12090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY148_RS12095	COG1940	carbohydrate kinase activity
FY148_RS12105	COG0671	phosphoesterase, PA-phosphatase related
FY148_RS12110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY148_RS12115	COG0156	8-amino-7-oxononanoate synthase activity
FY148_RS12125	COG0729	surface antigen
FY148_RS12135	COG0835	chemotaxis
FY148_RS12145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY148_RS12150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY148_RS12155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY148_RS12160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY148_RS12165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY148_RS12170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY148_RS12185	COG4974	Belongs to the 'phage' integrase family
FY148_RS12210	COG1280	lysine exporter protein (LysE YggA)
FY148_RS12220	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY148_RS12225	COG0567	Dehydrogenase, E1 component
FY148_RS12230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY148_RS12235	COG0045	succinate-CoA ligase (ADP-forming) activity
FY148_RS12240	COG0039	L-malate dehydrogenase activity
FY148_RS12245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY148_RS12280	COG2264	protein methyltransferase activity
FY148_RS12295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY148_RS12300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY148_RS12305	COG0181	hydroxymethylbilane synthase activity
FY148_RS12345	COG1872	DUF167
FY148_RS12350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY148_RS12360	COG1217	gtp-binding protein TYPA
FY148_RS12365	COG0339	signal peptide processing
FY148_RS12370	COG1846	Transcriptional regulator
FY148_RS12380	COG0137	argininosuccinate synthase activity
FY148_RS12390	COG1280	lysine exporter protein (LysE YggA)
FY148_RS12395	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY148_RS12400	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY148_RS12410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY148_RS12425	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY148_RS12430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY148_RS12435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY148_RS12445	COG4181	ATPase activity
FY148_RS12455	COG0670	Belongs to the BI1 family
FY148_RS12470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY148_RS12475	COG4133	protoheme IX ABC transporter activity
FY148_RS12480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY148_RS12485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY148_RS12510	COG2917	probably involved in intracellular septation
FY148_RS12515	COG0552	protein localization to endoplasmic reticulum
FY148_RS12520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY148_RS12525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY148_RS12535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY148_RS12540	COG1605	Chorismate mutase
FY148_RS12540	COG0287	Prephenate dehydrogenase
FY148_RS12545	COG0228	four-way junction DNA binding
FY148_RS12550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY148_RS12555	COG0336	Belongs to the RNA methyltransferase TrmD family
FY148_RS12565	COG0335	large ribosomal subunit rRNA binding
FY148_RS12570	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY148_RS12575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS12590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY148_RS12610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY148_RS12630	COG0488	(ABC) transporter
FY148_RS12640	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY148_RS12650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY148_RS12655	COG0142	geranyltranstransferase activity
FY148_RS12660	COG2885	chlorophyll binding
FY148_RS12665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY148_RS12670	COG2223	nitrite transmembrane transporter activity
FY148_RS12675	COG1349	DNA-binding transcription factor activity
FY148_RS12680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY148_RS12685	COG2197	response regulator
FY148_RS12690	COG1132	(ABC) transporter
FY148_RS12700	COG3459	Glycosyltransferase 36 associated
FY148_RS12705	COG1473	amidohydrolase
FY148_RS12715	COG0579	oxidoreductase
FY148_RS12725	COG0129	dihydroxy-acid dehydratase activity
FY148_RS12730	COG2084	Dehydrogenase
FY148_RS12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS12740	COG0277	FAD linked oxidase domain protein
FY148_RS12745	COG2186	Transcriptional regulator
FY148_RS12755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY148_RS12760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY148_RS12765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY148_RS12770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY148_RS12780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY148_RS12785	COG0495	leucyl-tRNA aminoacylation
FY148_RS12800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY148_RS12805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY148_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY148_RS12825	COG1946	Acyl-CoA thioesterase
FY148_RS12830	COG0347	Belongs to the P(II) protein family
FY148_RS12835	COG0004	ammonium transporteR
FY148_RS12840	COG1674	ftsk spoiiie
FY148_RS12845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY148_RS12860	COG0745	RESPONSE REGULATOR receiver
FY148_RS12870	COG1329	Transcriptional regulator
FY148_RS12880	COG2270	Major facilitator Superfamily
FY148_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS12910	COG0494	nUDIX hydrolase
FY148_RS12915	COG2861	carbohydrate metabolic process
FY148_RS12920	COG0793	Belongs to the peptidase S41A family
FY148_RS12930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY148_RS12935	COG0799	negative regulation of ribosome biogenesis
FY148_RS12940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY148_RS12945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY148_RS12950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY148_RS12955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY148_RS12970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY148_RS12975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY148_RS13000	COG0066	3-isopropylmalate dehydratase activity
FY148_RS13005	COG0473	3-isopropylmalate dehydrogenase activity
FY148_RS13010	COG1858	cytochrome C peroxidase
FY148_RS13015	COG1797	cobyrinic acid a,c-diamide synthase activity
FY148_RS13025	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY148_RS13090	COG1492	cobalamin metabolic process
FY148_RS13105	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS13110	COG3254	rhamnose metabolic process
FY148_RS13120	COG1063	alcohol dehydrogenase
FY148_RS13145	COG1129	ABC transporter
FY148_RS13150	COG2186	Transcriptional regulator
FY148_RS13155	COG2721	sulfolactate sulfo-lyase activity
FY148_RS13160	COG0138	bifunctional purine biosynthesis protein purh
FY148_RS13170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY148_RS13170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY148_RS13175	COG0501	Belongs to the peptidase M48B family
FY148_RS13195	COG0357	Ribosomal RNA small subunit methyltransferase G
FY148_RS13200	COG0445	tRNA wobble uridine modification
FY148_RS13205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY148_RS13210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY148_RS13215	COG1981	membrane
FY148_RS13220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY148_RS13225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY148_RS13230	COG0424	maF-like protein
FY148_RS13235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY148_RS13240	COG0237	dephospho-CoA kinase activity
FY148_RS13250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY148_RS13255	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY148_RS13265	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY148_RS13290	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY148_RS13305	COG0135	phosphoribosylanthranilate isomerase activity
FY148_RS13310	COG0133	tryptophan synthase activity
FY148_RS13315	COG0159	tryptophan synthase activity
FY148_RS13320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY148_RS13335	COG1074	ATP-dependent DNA helicase activity
FY148_RS13345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY148_RS13350	COG0802	atpase or kinase
FY148_RS13355	COG2205	protein histidine kinase activity
FY148_RS13360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY148_RS13365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY148_RS13370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY148_RS13370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY148_RS13375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY148_RS13380	COG0642	Histidine kinase
FY148_RS13385	COG0745	RESPONSE REGULATOR receiver
FY148_RS13390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY148_RS13400	COG1652	LysM domain
FY148_RS13405	COG1072	(Pantothenic acid kinase))
FY148_RS13410	COG0140	phosphoribosyl-ATP diphosphatase activity
FY148_RS13415	COG0107	imidazoleglycerol-phosphate synthase activity
FY148_RS13420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY148_RS13425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY148_RS13435	COG0131	Imidazoleglycerol-phosphate dehydratase
FY148_RS13440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY148_RS13445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY148_RS13455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY148_RS13470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY148_RS13480	COG1643	Atp-dependent helicase
FY148_RS13525	COG1940	carbohydrate kinase activity
FY148_RS13545	COG1072	(Pantothenic acid kinase))
FY148_RS13555	COG1780	Probably involved in ribonucleotide reductase function
FY148_RS13575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY148_RS13605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS13615	COG2813	Specifically methylates the guanine in position
FY148_RS13620	COG1185	polyribonucleotide nucleotidyltransferase activity
FY148_RS13625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY148_RS13630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY148_RS13635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY148_RS13640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY148_RS13640	COG3064	Membrane
FY148_RS13655	COG0779	Required for maturation of 30S ribosomal subunits
FY148_RS13660	COG2814	Major facilitator Superfamily
FY148_RS13670	COG2951	lytic endotransglycosylase activity
FY148_RS13675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY148_RS13685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY148_RS13690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY148_RS13705	COG2816	NAD+ diphosphatase activity
FY148_RS13710	COG1605	Chorismate mutase
FY148_RS13710	COG0077	Prephenate dehydratase
FY148_RS13715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY148_RS13720	COG3474	cytochrome
FY148_RS13730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY148_RS13735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY148_RS13740	COG1278	Cold shock
FY148_RS13745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY148_RS13755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY148_RS13755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY148_RS13760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY148_RS13790	COG2900	Belongs to the SlyX family
FY148_RS13800	COG0484	heat shock protein binding
FY148_RS13805	COG0443	Heat shock 70 kDa protein
FY148_RS13820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY148_RS13825	COG1744	ABC transporter substrate-binding protein PnrA-like
FY148_RS13830	COG3845	ABC transporter
FY148_RS13835	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY148_RS13840	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY148_RS13845	COG0295	cytidine deaminase activity
FY148_RS13855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY148_RS13860	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY148_RS13870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY148_RS13875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY148_RS13880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY148_RS13890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY148_RS13895	COG1845	cytochrome c oxidase, subunit III
FY148_RS13900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY148_RS13905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY148_RS13910	COG0477	Major facilitator Superfamily
FY148_RS13915	COG0069	glutamate synthase activity
FY148_RS13915	COG0070	glutamate synthase
FY148_RS13915	COG0067	glutamate synthase
FY148_RS13920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY148_RS13935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY148_RS13945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY148_RS13975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS13995	COG0848	biopolymer transport protein
FY148_RS14005	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY148_RS14020	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY148_RS14025	COG3454	Phosphonate metabolism
FY148_RS14030	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY148_RS14035	COG3639	organic phosphonate transmembrane transporter activity
FY148_RS14040	COG3639	organic phosphonate transmembrane transporter activity
FY148_RS14050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY148_RS14060	COG4778	phosphonate C-P lyase system protein PhnL
FY148_RS14065	COG4107	phosphonate C-P lyase system protein PhnK
FY148_RS14070	COG3627	carbon phosphorus lyase activity
FY148_RS14075	COG3626	phosphonate metabolism
FY148_RS14080	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY148_RS14085	COG3624	Phosphonate C-P lyase system protein PhnG
FY148_RS14090	COG2188	Transcriptional regulator
FY148_RS14095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY148_RS14100	COG0837	glucose binding
FY148_RS14105	COG1803	Methylglyoxal synthase
FY148_RS14110	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY148_RS14115	COG4166	transmembrane transport
FY148_RS14120	COG4174	ABC transporter (Permease)
FY148_RS14125	COG4239	(ABC) transporter, permease
FY148_RS14130	COG4172	Belongs to the ABC transporter superfamily
FY148_RS14135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS14140	COG0174	glutamine synthetase
FY148_RS14145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS14150	COG3265	gluconokinase activity
FY148_RS14155	COG1174	glycine betaine transport
FY148_RS14160	COG1125	glycine betaine transport
FY148_RS14165	COG1174	glycine betaine transport
FY148_RS14170	COG1732	Glycine betaine
FY148_RS14180	COG1959	2 iron, 2 sulfur cluster binding
FY148_RS14185	COG1840	ABC-type Fe3 transport system, periplasmic component
FY148_RS14195	COG4269	membrane
FY148_RS14210	COG0697	spore germination
FY148_RS14225	COG0791	NLP P60 protein
FY148_RS14235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY148_RS14240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY148_RS14275	COG4964	Belongs to the GSP D family
FY148_RS14320	COG3422	double-strand break repair
FY148_RS14325	COG3757	hydrolase, family 25
FY148_RS14330	COG0697	spore germination
FY148_RS14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY148_RS14350	COG0492	ferredoxin-NADP+ reductase activity
FY148_RS14365	COG0481	GTPase activity
FY148_RS14370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY148_RS14385	COG1396	sequence-specific DNA binding
FY148_RS14400	COG1917	Cupin 2, conserved barrel domain protein
FY148_RS14400	COG2169	Transcriptional regulator
FY148_RS14405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY148_RS14430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY148_RS14435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY148_RS14440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY148_RS14450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY148_RS14455	COG0072	phenylalanine-tRNA ligase activity
FY148_RS14455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY148_RS14460	COG0667	Aldo Keto reductase
FY148_RS14480	COG4977	sequence-specific DNA binding
FY148_RS14505	COG1570	exodeoxyribonuclease VII activity
FY148_RS14510	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS14520	COG1846	Transcriptional regulator
FY148_RS14525	COG0697	spore germination
FY148_RS14530	COG2309	aminopeptidase activity
FY148_RS14540	COG1393	Belongs to the ArsC family
FY148_RS14560	COG1309	transcriptional regulator
FY148_RS14570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY148_RS14570	COG0519	Catalyzes the synthesis of GMP from XMP
FY148_RS14585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY148_RS14615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY148_RS14625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY148_RS14635	COG1968	undecaprenyl-diphosphatase activity
FY148_RS14650	COG0284	orotidine-5'-phosphate decarboxylase activity
FY148_RS14660	COG3963	phosphatidate phosphatase activity
FY148_RS14670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY148_RS14675	COG0792	nuclease activity
FY148_RS14690	COG1175	transmembrane transport
FY148_RS14695	COG0395	ABC-type sugar transport system, permease component
FY148_RS14700	COG3842	ATPase activity
FY148_RS14710	COG0189	ligase activity
FY148_RS14715	COG0606	chelatase, subunit chli
FY148_RS14720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY148_RS14725	COG1280	lysine exporter protein (LysE YggA)
FY148_RS14730	COG0756	dUTP diphosphatase activity
FY148_RS14735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY148_RS14740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY148_RS14755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY148_RS14760	COG2226	methyltransferase
FY148_RS14765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY148_RS14770	COG1024	Enoyl-CoA hydratase
FY148_RS14775	COG0268	Binds directly to 16S ribosomal RNA
FY148_RS14790	COG2274	protein secretion by the type I secretion system
FY148_RS14805	COG0640	Transcriptional regulator
FY148_RS14840	COG4178	(ABC) transporter
FY148_RS14865	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS14870	COG0572	uridine kinase
FY148_RS14880	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS14885	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS14890	COG1129	ABC transporter
FY148_RS14910	COG3284	Transcriptional regulator
FY148_RS14915	COG1063	alcohol dehydrogenase
FY148_RS14925	COG0110	maltose O-acetyltransferase activity
FY148_RS14930	COG1049	propionate catabolic process, 2-methylcitrate cycle
FY148_RS14955	COG0488	(ABC) transporter
FY148_RS14960	COG5265	(ABC) transporter
FY148_RS14965	COG3181	Tripartite tricarboxylate transporter family receptor
FY148_RS14970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY148_RS14980	COG3237	CsbD-like
FY148_RS15000	COG0395	ABC-type sugar transport system, permease component
FY148_RS15005	COG3842	ATPase activity
FY148_RS15015	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS15025	COG0405	Gamma-glutamyltransferase
FY148_RS15030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS15035	COG0601	transmembrane transport
FY148_RS15040	COG0747	negative chemotaxis
FY148_RS15045	COG2186	Transcriptional regulator
FY148_RS15055	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS15060	COG4172	Belongs to the ABC transporter superfamily
FY148_RS15065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS15070	COG0601	transmembrane transport
FY148_RS15075	COG0747	negative chemotaxis
FY148_RS15080	COG2186	Transcriptional regulator
FY148_RS15090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS15095	COG2223	nitrite transmembrane transporter activity
FY148_RS15105	COG3383	formate dehydrogenase (NAD+) activity
FY148_RS15125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY148_RS15140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY148_RS15150	COG0765	amino acid transport
FY148_RS15155	COG0765	amino acid transport
FY148_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS15175	COG3938	Belongs to the proline racemase family
FY148_RS15185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS15195	COG0765	amino acid transport
FY148_RS15210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY148_RS15215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS15225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY148_RS15230	COG0784	Response regulator, receiver
FY148_RS15250	COG0842	Transport permease protein
FY148_RS15255	COG0842	Transport permease protein
FY148_RS15255	COG1129	ABC transporter
FY148_RS15260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS15265	COG1486	melibiose metabolic process
FY148_RS15270	COG4172	Belongs to the ABC transporter superfamily
FY148_RS15275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS15280	COG0601	transmembrane transport
FY148_RS15285	COG0747	negative chemotaxis
FY148_RS15290	COG1486	melibiose metabolic process
FY148_RS15315	COG1940	carbohydrate kinase activity
FY148_RS15320	COG2182	Extracellular solute-binding protein
FY148_RS15325	COG1175	transmembrane transport
FY148_RS15330	COG0395	ABC-type sugar transport system, permease component
FY148_RS15335	COG0165	Argininosuccinate lyase
FY148_RS15340	COG3842	ATPase activity
FY148_RS15345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS15350	COG3119	arylsulfatase activity
FY148_RS15360	COG0583	DNA-binding transcription factor activity
FY148_RS15365	COG1120	ATPase activity
FY148_RS15370	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS15375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS15385	COG4774	siderophore transport
FY148_RS15400	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY148_RS15415	COG2205	protein histidine kinase activity
FY148_RS15420	COG0745	RESPONSE REGULATOR receiver
FY148_RS15425	COG1566	PFAM secretion protein HlyD family protein
FY148_RS15440	COG1392	Phosphate transport regulator
FY148_RS15445	COG0306	phosphate transporter
FY148_RS15450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY148_RS15460	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY148_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS15475	COG5001	Diguanylate cyclase
FY148_RS15475	COG3300	MHYT domain
FY148_RS15500	COG0601	transmembrane transport
FY148_RS15505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS15510	COG0444	Belongs to the ABC transporter superfamily
FY148_RS15520	COG3842	ATPase activity
FY148_RS15525	COG0395	ABC-type sugar transport system, permease component
FY148_RS15540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY148_RS15540	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY148_RS15545	COG1609	Transcriptional regulator
FY148_RS15555	COG0210	DNA helicase
FY148_RS15560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY148_RS15565	COG1088	dTDP-glucose 4,6-dehydratase activity
FY148_RS15570	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY148_RS15575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY148_RS15590	COG3754	Rhamnan synthesis protein F
FY148_RS15595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY148_RS15615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FY148_RS15625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FY148_RS15630	COG1216	Glycosyl transferase, family 2
FY148_RS15630	COG1442	glycosyl transferase family 8
FY148_RS15645	COG1132	(ABC) transporter
FY148_RS15655	COG0583	DNA-binding transcription factor activity
FY148_RS15660	COG0667	Aldo Keto reductase
FY148_RS15680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY148_RS15695	COG0300	oxidoreductase activity
FY148_RS15700	COG0584	glycerophosphoryl diester phosphodiesterase
FY148_RS15705	COG1940	carbohydrate kinase activity
FY148_RS15715	COG3712	iron ion homeostasis
FY148_RS15720	COG4774	siderophore transport
FY148_RS15725	COG2814	Major facilitator Superfamily
FY148_RS15745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY148_RS15755	COG3842	ATPase activity
FY148_RS15760	COG1175	transmembrane transport
FY148_RS15765	COG0395	ABC-type sugar transport system, permease component
FY148_RS15770	COG1609	Transcriptional regulator
FY148_RS15780	COG0673	inositol 2-dehydrogenase activity
FY148_RS15785	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS15800	COG1609	Transcriptional regulator
FY148_RS15805	COG0183	Belongs to the thiolase family
FY148_RS15810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY148_RS15820	COG1414	Transcriptional regulator
FY148_RS15835	COG0583	DNA-binding transcription factor activity
FY148_RS15845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY148_RS15850	COG3485	protocatechuate 3,4-dioxygenase
FY148_RS15855	COG3485	protocatechuate 3,4-dioxygenase
FY148_RS15860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY148_RS15865	COG0765	amino acid transport
FY148_RS15870	COG0765	amino acid transport
FY148_RS15875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS15880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS15885	COG1126	abc transporter atp-binding protein
FY148_RS15890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY148_RS15895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY148_RS15920	COG4172	Belongs to the ABC transporter superfamily
FY148_RS15925	COG0747	negative chemotaxis
FY148_RS15935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS15950	COG0683	leucine binding
FY148_RS15965	COG0411	ABC transporter
FY148_RS15980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS15985	COG3962	Belongs to the TPP enzyme family
FY148_RS15995	COG3718	enzyme involved in inositol metabolism
FY148_RS16005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY148_RS16010	COG1609	Transcriptional regulator
FY148_RS16015	COG1846	Transcriptional regulator
FY148_RS16025	COG0523	cobalamin synthesis protein
FY148_RS16060	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY148_RS16080	COG0800	Aldolase
FY148_RS16085	COG2954	triphosphatase activity
FY148_RS16095	COG1054	Belongs to the UPF0176 family
FY148_RS16100	COG3300	MHYT domain
FY148_RS16100	COG5001	Diguanylate cyclase
FY148_RS16110	COG2011	ABC-type metal ion transport system permease component
FY148_RS16115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY148_RS16120	COG0778	Nitroreductase
FY148_RS16135	COG2115	Belongs to the xylose isomerase family
FY148_RS16140	COG1070	Carbohydrate kinase
FY148_RS16145	COG1609	Transcriptional regulator
FY148_RS16165	COG1309	transcriptional regulator
FY148_RS16170	COG1253	flavin adenine dinucleotide binding
FY148_RS16175	COG0471	metal ion transport
FY148_RS16175	COG3273	potassium ion transport
FY148_RS16180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY148_RS16185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY148_RS16190	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY148_RS16200	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY148_RS16205	COG1121	(ABC) transporter
FY148_RS16210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY148_RS16215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY148_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS16230	COG1414	Transcriptional regulator
FY148_RS16235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY148_RS16255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY148_RS16280	COG1069	ribulokinase activity
FY148_RS16305	COG0395	ABC-type sugar transport system, permease component
FY148_RS16310	COG1175	transmembrane transport
FY148_RS16320	COG2390	Transcriptional regulator
FY148_RS16325	COG4172	Belongs to the ABC transporter superfamily
FY148_RS16330	COG1473	amidohydrolase
FY148_RS16340	COG0601	transmembrane transport
FY148_RS16345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS16355	COG0693	protein deglycase activity
FY148_RS16360	COG0154	amidase activity
FY148_RS16365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS16375	COG0747	negative chemotaxis
FY148_RS16380	COG0583	DNA-binding transcription factor activity
FY148_RS16385	COG4608	Belongs to the ABC transporter superfamily
FY148_RS16390	COG0444	Belongs to the ABC transporter superfamily
FY148_RS16395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS16400	COG0601	transmembrane transport
FY148_RS16405	COG0747	negative chemotaxis
FY148_RS16415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY148_RS16420	COG1473	amidohydrolase
FY148_RS16425	COG2814	Major facilitator Superfamily
FY148_RS16430	COG0583	DNA-binding transcription factor activity
FY148_RS16435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY148_RS16455	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS16465	COG1609	Transcriptional regulator
FY148_RS16470	COG0583	DNA-binding transcription factor activity
FY148_RS16475	COG1960	acyl-CoA dehydrogenase activity
FY148_RS16480	COG1629	transport
FY148_RS16480	COG4774	siderophore transport
FY148_RS16490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS16500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS16515	COG2375	cellular response to nickel ion
FY148_RS16525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY148_RS16530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY148_RS16530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY148_RS16540	COG1169	isochorismate synthase
FY148_RS16545	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY148_RS16550	COG3433	isochorismatase activity
FY148_RS16550	COG1535	isochorismatase
FY148_RS16555	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS16570	COG3005	denitrification pathway
FY148_RS16580	COG0243	molybdopterin cofactor binding
FY148_RS16595	COG4459	periplasmic nitrate reductase
FY148_RS16605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FY148_RS16630	COG0826	peptidase U32
FY148_RS16640	COG3189	MarR family transcriptional regulator
FY148_RS16645	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY148_RS16680	COG3256	nitric oxide reductase
FY148_RS16685	COG0714	Associated with various cellular activities
FY148_RS16745	COG0673	inositol 2-dehydrogenase activity
FY148_RS16755	COG1609	Transcriptional regulator
FY148_RS16760	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS16765	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS16770	COG1129	ABC transporter
FY148_RS16775	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS16785	COG0583	DNA-binding transcription factor activity
FY148_RS16800	COG1609	Transcriptional regulator
FY148_RS16805	COG0673	inositol 2-dehydrogenase activity
FY148_RS16815	COG1653	transport
FY148_RS16820	COG1175	transmembrane transport
FY148_RS16825	COG0395	ABC-type sugar transport system, permease component
FY148_RS16830	COG3842	ATPase activity
FY148_RS16845	COG1253	flavin adenine dinucleotide binding
FY148_RS16870	COG3300	MHYT domain
FY148_RS16870	COG5001	Diguanylate cyclase
FY148_RS17000	COG0477	Major facilitator Superfamily
FY148_RS17020	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS17030	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS17040	COG1063	alcohol dehydrogenase
FY148_RS17055	COG1136	(ABC) transporter
FY148_RS17070	COG1309	transcriptional regulator
FY148_RS17085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY148_RS17095	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY148_RS17095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY148_RS17105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS17110	COG0047	phosphoribosylformylglycinamidine synthase activity
FY148_RS17120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS17125	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS17130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS17140	COG3448	diguanylate cyclase activity
FY148_RS17140	COG4175	Glycine betaine
FY148_RS17150	COG4176	ABC-type proline glycine betaine transport system permease component
FY148_RS17155	COG3938	Belongs to the proline racemase family
FY148_RS17160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY148_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS17195	COG1733	regulation of RNA biosynthetic process
FY148_RS17205	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FY148_RS17245	COG0477	Major facilitator Superfamily
FY148_RS17255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY148_RS17265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY148_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS17290	COG0395	ABC-type sugar transport system, permease component
FY148_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS17320	COG1349	DNA-binding transcription factor activity
FY148_RS17325	COG1069	ribulokinase activity
FY148_RS17345	COG1940	carbohydrate kinase activity
FY148_RS17360	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS17365	COG1177	transmembrane transport
FY148_RS17375	COG3842	ATPase activity
FY148_RS17440	COG1136	(ABC) transporter
FY148_RS17440	COG0577	efflux transmembrane transporter activity
FY148_RS17465	COG1845	cytochrome c oxidase, subunit III
FY148_RS17470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY148_RS17475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY148_RS17480	COG3474	cytochrome
FY148_RS17505	COG3842	ATPase activity
FY148_RS17510	COG0395	ABC-type sugar transport system, permease component
FY148_RS17515	COG1175	transmembrane transport
FY148_RS17520	COG1653	transport
FY148_RS17525	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS17530	COG1024	Enoyl-CoA hydratase
FY148_RS17550	COG4702	Belongs to the UPF0303 family
FY148_RS17555	COG1629	transport
FY148_RS17555	COG4774	siderophore transport
FY148_RS17560	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FY148_RS17565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS17570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS17575	COG1120	ATPase activity
FY148_RS17590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY148_RS17600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY148_RS17605	COG1177	transmembrane transport
FY148_RS17610	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS17615	COG3842	ATPase activity
FY148_RS17640	COG1335	isochorismatase
FY148_RS17655	COG0583	DNA-binding transcription factor activity
FY148_RS17660	COG2318	DinB family
FY148_RS17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY148_RS17715	COG0778	Nitroreductase
FY148_RS17735	COG0277	FAD linked oxidase domain protein
FY148_RS17755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS17760	COG4172	Belongs to the ABC transporter superfamily
FY148_RS17770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS17780	COG0431	NADPH-dependent FMN reductase
FY148_RS17800	COG1522	sequence-specific DNA binding
FY148_RS17805	COG2376	Dihydroxyacetone kinase
FY148_RS17910	COG3609	addiction module antidote protein, CC2985 family
FY148_RS17950	COG0741	lytic transglycosylase activity
FY148_RS17950	COG0739	heme binding
FY148_RS17950	COG1196	nuclear chromosome segregation
FY148_RS17955	COG0542	response to heat
FY148_RS17965	COG2890	protein-(glutamine-N5) methyltransferase activity
FY148_RS17970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY148_RS17980	COG0527	aspartate kinase activity
FY148_RS17995	COG0019	diaminopimelate decarboxylase activity
FY148_RS18010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY148_RS18020	COG3920	Histidine kinase
FY148_RS18030	COG0784	Response regulator, receiver
FY148_RS18045	COG1522	sequence-specific DNA binding
FY148_RS18055	COG1116	anion transmembrane transporter activity
FY148_RS18060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS18065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY148_RS18070	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS18075	COG0583	DNA-binding transcription factor activity
FY148_RS18080	COG0435	Glutathione S-transferase
FY148_RS18095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY148_RS18100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS18105	COG0189	ligase activity
FY148_RS18125	COG0693	protein deglycase activity
FY148_RS18155	COG3685	Protein conserved in bacteria
FY148_RS18160	COG4993	Dehydrogenase
FY148_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS18180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY148_RS18225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS18240	COG0246	Mannitol dehydrogenase
FY148_RS18245	COG4608	Belongs to the ABC transporter superfamily
FY148_RS18250	COG0444	Belongs to the ABC transporter superfamily
FY148_RS18255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS18260	COG0601	transmembrane transport
FY148_RS18265	COG0747	negative chemotaxis
FY148_RS18275	COG4221	oxidoreductase activity
FY148_RS18305	COG0539	negative regulation of cytoplasmic translation
FY148_RS18310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY148_RS18340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY148_RS18345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY148_RS18375	COG1294	oxidase, subunit
FY148_RS18385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY148_RS18390	COG4988	ABC transporter
FY148_RS18400	COG1063	alcohol dehydrogenase
FY148_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS18410	COG2084	Dehydrogenase
FY148_RS18420	COG1522	sequence-specific DNA binding
FY148_RS18425	COG1794	racemase activity, acting on amino acids and derivatives
FY148_RS18440	COG0058	SHG alpha-glucan phosphorylase activity
FY148_RS18445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY148_RS18450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY148_RS18455	COG0297	glycogen (starch) synthase activity
FY148_RS18460	COG0033	Phosphoglucomutase
FY148_RS18465	COG1523	belongs to the glycosyl hydrolase 13 family
FY148_RS18495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY148_RS18495	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY148_RS18510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS18515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY148_RS18535	COG1215	transferase activity, transferring glycosyl groups
FY148_RS18540	COG2327	Polysaccharide pyruvyl transferase
FY148_RS18545	COG0463	Glycosyl transferase, family 2
FY148_RS18550	COG2244	polysaccharide biosynthetic process
FY148_RS18555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY148_RS18560	COG2273	Hydrolase Family 16
FY148_RS18565	COG0438	transferase activity, transferring glycosyl groups
FY148_RS18570	COG1215	transferase activity, transferring glycosyl groups
FY148_RS18575	COG1215	transferase activity, transferring glycosyl groups
FY148_RS18580	COG1215	transferase activity, transferring glycosyl groups
FY148_RS18585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY148_RS18590	COG3206	protein involved in exopolysaccharide biosynthesis
FY148_RS18590	COG0489	protein tyrosine kinase activity
FY148_RS18595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY148_RS18600	COG4191	Histidine kinase
FY148_RS18600	COG0784	Response regulator, receiver
FY148_RS18615	COG4176	ABC-type proline glycine betaine transport system permease component
FY148_RS18620	COG4175	Glycine betaine
FY148_RS18620	COG3448	diguanylate cyclase activity
FY148_RS18635	COG0564	pseudouridine synthase activity
FY148_RS18640	COG0500	methyltransferase
FY148_RS18650	COG2133	pyrroloquinoline quinone binding
FY148_RS18660	COG2197	response regulator
FY148_RS18665	COG4585	Histidine kinase
FY148_RS18670	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS18675	COG1129	ABC transporter
FY148_RS18680	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS18690	COG3386	PFAM SMP-30 Gluconolaconase
FY148_RS18695	COG2137	regulation of response to DNA damage stimulus
FY148_RS18700	COG3474	cytochrome
FY148_RS18710	COG1120	ATPase activity
FY148_RS18725	COG4774	siderophore transport
FY148_RS18730	COG0583	DNA-binding transcription factor activity
FY148_RS18740	COG2194	sulfuric ester hydrolase activity
FY148_RS18755	COG0477	Major facilitator Superfamily
FY148_RS18775	COG0673	inositol 2-dehydrogenase activity
FY148_RS18780	COG0697	spore germination
FY148_RS18790	COG0010	Belongs to the arginase family
FY148_RS18805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY148_RS18810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY148_RS18815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY148_RS18820	COG0156	8-amino-7-oxononanoate synthase activity
FY148_RS18825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY148_RS18875	COG0671	phosphoesterase, PA-phosphatase related
FY148_RS18880	COG0745	RESPONSE REGULATOR receiver
FY148_RS18885	COG2205	protein histidine kinase activity
FY148_RS18895	COG0477	Major facilitator Superfamily
FY148_RS18900	COG0583	DNA-binding transcription factor activity
FY148_RS18920	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY148_RS18935	COG0346	lactoylglutathione lyase activity
FY148_RS18940	COG0583	DNA-binding transcription factor activity
FY148_RS18970	COG1215	transferase activity, transferring glycosyl groups
FY148_RS18990	COG0840	transmembrane signaling receptor activity
FY148_RS19005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS19020	COG2828	Protein conserved in bacteria
FY148_RS19025	COG0583	DNA-binding transcription factor activity
FY148_RS19030	COG1846	Transcriptional regulator
FY148_RS19055	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS19060	COG1309	transcriptional regulator
FY148_RS19065	COG2207	Transcriptional regulator
FY148_RS19080	COG1566	PFAM secretion protein HlyD family protein
FY148_RS19095	COG0395	ABC-type sugar transport system, permease component
FY148_RS19100	COG4166	transmembrane transport
FY148_RS19105	COG0601	transmembrane transport
FY148_RS19110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS19115	COG4172	Belongs to the ABC transporter superfamily
FY148_RS19120	COG4221	oxidoreductase activity
FY148_RS19125	COG0625	glutathione transferase activity
FY148_RS19135	COG1566	PFAM secretion protein HlyD family protein
FY148_RS19145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY148_RS19150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY148_RS19165	COG0534	Mate efflux family protein
FY148_RS19200	COG1733	regulation of RNA biosynthetic process
FY148_RS19210	COG1136	(ABC) transporter
FY148_RS19210	COG0577	efflux transmembrane transporter activity
FY148_RS19215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS19225	COG0745	RESPONSE REGULATOR receiver
FY148_RS19245	COG3209	COG3209 Rhs family protein
FY148_RS19275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS19300	COG3177	Filamentation induced by cAMP protein fic
FY148_RS19315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS19320	COG4597	amino acid ABC transporter
FY148_RS19325	COG0765	amino acid transport
FY148_RS19350	COG0747	negative chemotaxis
FY148_RS19355	COG0601	transmembrane transport
FY148_RS19360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS19365	COG0444	Belongs to the ABC transporter superfamily
FY148_RS19370	COG4608	Belongs to the ABC transporter superfamily
FY148_RS19390	COG4213	ABC transporter substrate-binding protein
FY148_RS19395	COG1129	ABC transporter
FY148_RS19400	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS19415	COG0667	Aldo Keto reductase
FY148_RS19440	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS19445	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS19450	COG1129	ABC transporter
FY148_RS19460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS19470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS19480	COG0747	negative chemotaxis
FY148_RS19485	COG0747	negative chemotaxis
FY148_RS19490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS19500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS19505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS19510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY148_RS19540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS19545	COG0436	Aminotransferase
FY148_RS19560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS19565	COG0765	amino acid transport
FY148_RS19575	COG1126	abc transporter atp-binding protein
FY148_RS19585	COG2186	Transcriptional regulator
FY148_RS19605	COG1846	Transcriptional regulator
FY148_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS19620	COG0583	DNA-binding transcription factor activity
FY148_RS19655	COG0583	DNA-binding transcription factor activity
FY148_RS19675	COG1280	lysine exporter protein (LysE YggA)
FY148_RS19680	COG3920	Histidine kinase
FY148_RS19705	COG0753	catalase activity
FY148_RS19725	COG1278	Cold shock
FY148_RS19760	COG2267	carboxylic ester hydrolase activity
FY148_RS19765	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS19770	COG1902	pentaerythritol trinitrate reductase activity
FY148_RS19775	COG4221	oxidoreductase activity
FY148_RS19780	COG1309	transcriptional regulator
FY148_RS19795	COG1280	lysine exporter protein (LysE YggA)
FY148_RS19805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY148_RS19850	COG0402	S-adenosylhomocysteine deaminase activity
FY148_RS19855	COG1228	amidohydrolase
FY148_RS19860	COG2986	histidine ammonia-lyase
FY148_RS19870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY148_RS19900	COG1192	Involved in chromosome partitioning
FY148_RS19905	COG1475	DNA binding
FY148_RS19910	COG1414	Transcriptional regulator
FY148_RS19930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY148_RS19935	COG4771	TonB-dependent receptor
FY148_RS19945	COG0366	Alpha amylase catalytic
FY148_RS19950	COG4770	biotin carboxylase activity
FY148_RS19955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY148_RS19960	COG4336	lyase activity
FY148_RS19965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY148_RS19970	COG1914	H( )-stimulated, divalent metal cation uptake system
FY148_RS19975	COG1802	Transcriptional regulator
FY148_RS19980	COG3707	response regulator
FY148_RS19990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY148_RS19995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS20000	COG1116	anion transmembrane transporter activity
FY148_RS20005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY148_RS20015	COG0243	molybdopterin cofactor binding
FY148_RS20020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY148_RS20020	COG1648	precorrin-2 dehydrogenase activity
FY148_RS20035	COG3842	ATPase activity
FY148_RS20050	COG0395	ABC-type sugar transport system, permease component
FY148_RS20065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY148_RS20080	COG0071	Belongs to the small heat shock protein (HSP20) family
FY148_RS20125	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS20130	COG1129	ABC transporter
FY148_RS20135	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS20145	COG0667	Aldo Keto reductase
FY148_RS20150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY148_RS20155	COG1830	Aldolase
FY148_RS20160	COG1070	Carbohydrate kinase
FY148_RS20165	COG0840	transmembrane signaling receptor activity
FY148_RS20165	COG2972	Histidine kinase
FY148_RS20180	COG0436	Aminotransferase
FY148_RS20190	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY148_RS20200	COG3842	ATPase activity
FY148_RS20205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY148_RS20210	COG1984	allophanate hydrolase subunit 2
FY148_RS20215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY148_RS20225	COG0439	Biotin carboxylase
FY148_RS20230	COG0511	ligase activity, forming carbon-carbon bonds
FY148_RS20235	COG0697	spore germination
FY148_RS20240	COG0697	spore germination
FY148_RS20255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY148_RS20270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS20280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY148_RS20285	COG4221	oxidoreductase activity
FY148_RS20290	COG0765	amino acid transport
FY148_RS20295	COG0765	amino acid transport
FY148_RS20305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS20310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY148_RS20315	COG1063	alcohol dehydrogenase
FY148_RS20330	COG1304	FMN binding
FY148_RS20355	COG3842	ATPase activity
FY148_RS20365	COG0395	ABC-type sugar transport system, permease component
FY148_RS20370	COG1175	transmembrane transport
FY148_RS20385	COG2186	Transcriptional regulator
FY148_RS20390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY148_RS20395	COG0488	(ABC) transporter
FY148_RS20410	COG2307	Protein conserved in bacteria
FY148_RS20410	COG2308	Evidence 4 Homologs of previously reported genes of
FY148_RS20450	COG1454	alcohol dehydrogenase
FY148_RS20455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY148_RS20465	COG0747	negative chemotaxis
FY148_RS20470	COG0601	transmembrane transport
FY148_RS20475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS20485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS20495	COG1078	dGTPase activity
FY148_RS20525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY148_RS20545	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FY148_RS20550	COG0732	type I restriction modification DNA specificity domain
FY148_RS20575	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS20580	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS20585	COG0673	inositol 2-dehydrogenase activity
FY148_RS20590	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS20610	COG1609	Transcriptional regulator
FY148_RS20615	COG2986	histidine ammonia-lyase
FY148_RS20620	COG3448	diguanylate cyclase activity
FY148_RS20620	COG4175	Glycine betaine
FY148_RS20625	COG4176	ABC-type proline glycine betaine transport system permease component
FY148_RS20645	COG1309	transcriptional regulator
FY148_RS20665	COG2186	Transcriptional regulator
FY148_RS20670	COG1027	Aspartate ammonia-lyase
FY148_RS20680	COG0252	asparaginase activity
FY148_RS20690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY148_RS20700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY148_RS20705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY148_RS20710	COG2205	protein histidine kinase activity
FY148_RS20725	COG0067	glutamate synthase
FY148_RS20725	COG0070	glutamate synthase
FY148_RS20725	COG0069	glutamate synthase activity
FY148_RS20740	COG2205	protein histidine kinase activity
FY148_RS20745	COG0745	RESPONSE REGULATOR receiver
FY148_RS20755	COG2951	lytic endotransglycosylase activity
FY148_RS20760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY148_RS20790	COG0330	HflC and HflK could
FY148_RS20795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY148_RS20800	COG0737	Belongs to the 5'-nucleotidase family
FY148_RS20810	COG5310	Homospermidine synthase
FY148_RS20820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY148_RS20825	COG1164	Oligoendopeptidase f
FY148_RS20835	COG3108	Peptidase M15
FY148_RS20840	COG0469	pyruvate kinase activity
FY148_RS20860	COG3750	Belongs to the UPF0335 family
FY148_RS20865	COG0457	Tetratricopeptide repeat
FY148_RS20870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY148_RS20875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY148_RS20880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY148_RS20910	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS20930	COG1132	(ABC) transporter
FY148_RS20935	COG0254	rRNA binding
FY148_RS20960	COG3588	fructose-bisphosphate aldolase
FY148_RS20965	COG0126	phosphoglycerate kinase activity
FY148_RS21005	COG1253	flavin adenine dinucleotide binding
FY148_RS21015	COG1692	metallophosphoesterase
FY148_RS21030	COG0217	transcriptional regulatory protein
FY148_RS21035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS21040	COG0840	transmembrane signaling receptor activity
FY148_RS21040	COG2972	Histidine kinase
FY148_RS21045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY148_RS21050	COG0632	four-way junction helicase activity
FY148_RS21055	COG2255	four-way junction helicase activity
FY148_RS21070	COG0494	nUDIX hydrolase
FY148_RS21080	COG0824	Thioesterase
FY148_RS21100	COG0823	Involved in the tonB-independent uptake of proteins
FY148_RS21105	COG2885	chlorophyll binding
FY148_RS21115	COG0037	tRNA processing
FY148_RS21120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY148_RS21125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY148_RS21140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY148_RS21155	COG0482	sulfurtransferase activity
FY148_RS21190	COG2835	tetraacyldisaccharide 4'-kinase activity
FY148_RS21195	COG2373	Large extracellular alpha-helical protein
FY148_RS21200	COG4953	penicillin-binding protein 1C
FY148_RS21210	COG1473	amidohydrolase
FY148_RS21215	COG1686	Belongs to the peptidase S11 family
FY148_RS21220	COG0523	cobalamin synthesis protein
FY148_RS21225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY148_RS21225	COG0425	Belongs to the sulfur carrier protein TusA family
FY148_RS21230	COG3034	peptidoglycan biosynthetic process
FY148_RS21235	COG0825	malonyl-CoA metabolic process
FY148_RS21240	COG4974	Belongs to the 'phage' integrase family
FY148_RS21250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY148_RS21255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY148_RS21295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY148_RS21300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY148_RS21320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY148_RS21325	COG2226	methyltransferase
FY148_RS21330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY148_RS21335	COG0287	Prephenate dehydrogenase
FY148_RS21345	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY148_RS21365	COG2884	Cell division ATP-binding protein ftsE
FY148_RS21400	COG0165	Argininosuccinate lyase
FY148_RS21405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY148_RS21415	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY148_RS21425	COG2086	electron transfer activity
FY148_RS21435	COG2096	Adenosyltransferase
FY148_RS21445	COG0300	oxidoreductase activity
FY148_RS21455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY148_RS21465	COG1396	sequence-specific DNA binding
FY148_RS21465	COG3800	Transcriptional regulator
FY148_RS21470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY148_RS21475	COG0625	glutathione transferase activity
FY148_RS21490	COG4770	biotin carboxylase activity
FY148_RS21495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY148_RS21495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY148_RS21500	COG0346	lactoylglutathione lyase activity
FY148_RS21515	COG4213	ABC transporter substrate-binding protein
FY148_RS21520	COG4214	carbohydrate transport
FY148_RS21525	COG1129	ABC transporter
FY148_RS21530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY148_RS21540	COG1396	sequence-specific DNA binding
FY148_RS21595	COG3833	ABC-type maltose transport systems, permease component
FY148_RS21600	COG3842	ATPase activity
FY148_RS21615	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY148_RS21615	COG2273	Hydrolase Family 16
FY148_RS21620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY148_RS21635	COG0438	transferase activity, transferring glycosyl groups
FY148_RS21640	COG0438	transferase activity, transferring glycosyl groups
FY148_RS21660	COG3206	protein involved in exopolysaccharide biosynthesis
FY148_RS21660	COG0489	protein tyrosine kinase activity
FY148_RS21670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY148_RS21685	COG2244	polysaccharide biosynthetic process
FY148_RS21750	COG0697	spore germination
FY148_RS21755	COG0653	protein targeting
FY148_RS21760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY148_RS21765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY148_RS21775	COG0494	nUDIX hydrolase
FY148_RS21790	COG2226	methyltransferase
FY148_RS21795	COG1040	competence protein
FY148_RS21805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY148_RS21815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY148_RS21830	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY148_RS21835	COG4150	thiosulfate binding
FY148_RS21845	COG4208	sulfate ABC transporter
FY148_RS21850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY148_RS21855	COG4335	DNA alkylation repair
FY148_RS21870	COG5001	Diguanylate cyclase
FY148_RS21875	COG2264	protein methyltransferase activity
FY148_RS21890	COG3254	rhamnose metabolic process
FY148_RS21895	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS21900	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS21905	COG1129	ABC transporter
FY148_RS21915	COG1349	DNA-binding transcription factor activity
FY148_RS21920	COG3347	Dehydrogenase
FY148_RS21920	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS21925	COG4952	isomerase
FY148_RS21930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY148_RS21935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY148_RS21955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY148_RS21960	COG1960	acyl-CoA dehydrogenase activity
FY148_RS21970	COG0183	Belongs to the thiolase family
FY148_RS21975	COG1960	acyl-CoA dehydrogenase activity
FY148_RS21985	COG0022	dehydrogenase e1 component
FY148_RS21995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY148_RS22000	COG2391	methyltransferase activity
FY148_RS22010	COG0640	Transcriptional regulator
FY148_RS22015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY148_RS22015	COG3453	Protein conserved in bacteria
FY148_RS22025	COG0300	oxidoreductase activity
FY148_RS22040	COG2186	Transcriptional regulator
FY148_RS22050	COG0601	transmembrane transport
FY148_RS22060	COG0444	Belongs to the ABC transporter superfamily
FY148_RS22065	COG4608	Belongs to the ABC transporter superfamily
FY148_RS22085	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS22090	COG1733	regulation of RNA biosynthetic process
FY148_RS22100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22125	COG1473	amidohydrolase
FY148_RS22130	COG0747	negative chemotaxis
FY148_RS22140	COG4166	transmembrane transport
FY148_RS22145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22150	COG0583	DNA-binding transcription factor activity
FY148_RS22160	COG0667	Aldo Keto reductase
FY148_RS22170	COG0444	Belongs to the ABC transporter superfamily
FY148_RS22185	COG0747	negative chemotaxis
FY148_RS22195	COG1960	acyl-CoA dehydrogenase activity
FY148_RS22225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY148_RS22240	COG1959	2 iron, 2 sulfur cluster binding
FY148_RS22245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22255	COG1473	amidohydrolase
FY148_RS22270	COG1126	abc transporter atp-binding protein
FY148_RS22275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS22285	COG0583	DNA-binding transcription factor activity
FY148_RS22300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS22310	COG1522	sequence-specific DNA binding
FY148_RS22315	COG4172	Belongs to the ABC transporter superfamily
FY148_RS22320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS22355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS22360	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS22365	COG0473	3-isopropylmalate dehydrogenase activity
FY148_RS22370	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS22415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS22420	COG1120	ATPase activity
FY148_RS22430	COG2226	methyltransferase
FY148_RS22445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS22450	COG1120	ATPase activity
FY148_RS22455	COG1595	DNA-templated transcription, initiation
FY148_RS22475	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY148_RS22480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS22500	COG0673	inositol 2-dehydrogenase activity
FY148_RS22505	COG0673	inositol 2-dehydrogenase activity
FY148_RS22515	COG1175	transmembrane transport
FY148_RS22520	COG0395	ABC-type sugar transport system, permease component
FY148_RS22535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS22540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY148_RS22545	COG2197	response regulator
FY148_RS22550	COG0601	transmembrane transport
FY148_RS22555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS22575	COG0747	negative chemotaxis
FY148_RS22590	COG1446	asparaginase
FY148_RS22595	COG0583	DNA-binding transcription factor activity
FY148_RS22600	COG0601	transmembrane transport
FY148_RS22605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS22620	COG0747	negative chemotaxis
FY148_RS22625	COG1473	amidohydrolase
FY148_RS22640	COG1129	ABC transporter
FY148_RS22645	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS22650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY148_RS22655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY148_RS22665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY148_RS22680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS22690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS22695	COG2079	MmgE PrpD family protein
FY148_RS22700	COG1126	abc transporter atp-binding protein
FY148_RS22705	COG0765	amino acid transport
FY148_RS22720	COG0281	malic enzyme
FY148_RS22720	COG0280	phosphate acetyltransferase
FY148_RS22725	COG0583	DNA-binding transcription factor activity
FY148_RS22750	COG1175	transmembrane transport
FY148_RS22755	COG0395	ABC-type sugar transport system, permease component
FY148_RS22770	COG0673	inositol 2-dehydrogenase activity
FY148_RS22780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY148_RS22785	COG0720	synthase
FY148_RS22790	COG0602	queuosine metabolic process
FY148_RS22795	COG0673	inositol 2-dehydrogenase activity
FY148_RS22805	COG3842	ATPase activity
FY148_RS22820	COG1653	transport
FY148_RS22825	COG1609	Transcriptional regulator
FY148_RS22840	COG2094	Belongs to the DNA glycosylase MPG family
FY148_RS22850	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS22860	COG1376	ErfK ybiS ycfS ynhG family protein
FY148_RS22865	COG2972	Histidine kinase
FY148_RS22865	COG0840	transmembrane signaling receptor activity
FY148_RS22870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY148_RS22880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY148_RS22885	COG1596	polysaccharide export
FY148_RS22890	COG3307	-O-antigen
FY148_RS22920	COG2197	response regulator
FY148_RS22930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS22955	COG2942	2-epimerase
FY148_RS22965	COG1215	transferase activity, transferring glycosyl groups
FY148_RS22985	COG1473	amidohydrolase
FY148_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS23000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY148_RS23005	COG1301	dicarboxylic acid transport
FY148_RS23010	COG4191	Histidine kinase
FY148_RS23015	COG2204	response regulator
FY148_RS23030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS23035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY148_RS23040	COG1522	sequence-specific DNA binding
FY148_RS23045	COG0351	phosphomethylpyrimidine kinase
FY148_RS23050	COG0352	thiamine-phosphate diphosphorylase activity
FY148_RS23055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY148_RS23060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY148_RS23065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS23075	COG1501	Belongs to the glycosyl hydrolase 31 family
FY148_RS23080	COG0395	ABC-type sugar transport system, permease component
FY148_RS23085	COG1175	transmembrane transport
FY148_RS23090	COG1653	transport
FY148_RS23095	COG3842	ATPase activity
FY148_RS23100	COG2188	Transcriptional regulator
FY148_RS23110	COG4989	oxidoreductase activity
FY148_RS23145	COG0438	transferase activity, transferring glycosyl groups
FY148_RS23150	COG0747	negative chemotaxis
FY148_RS23155	COG0601	transmembrane transport
FY148_RS23165	COG3964	amidohydrolase
FY148_RS23180	COG1921	L-seryl-tRNASec selenium transferase activity
FY148_RS23185	COG4172	Belongs to the ABC transporter superfamily
FY148_RS23190	COG0625	glutathione transferase activity
FY148_RS23205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS23210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY148_RS23210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY148_RS23215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY148_RS23235	COG1312	Catalyzes the dehydration of D-mannonate
FY148_RS23240	COG1063	alcohol dehydrogenase
FY148_RS23245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY148_RS23255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY148_RS23260	COG2186	Transcriptional regulator
FY148_RS23265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY148_RS23270	COG0850	regulation of cytokinetic process
FY148_RS23275	COG2894	cell division
FY148_RS23280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY148_RS23285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS23295	COG5001	Diguanylate cyclase
FY148_RS23310	COG0673	inositol 2-dehydrogenase activity
FY148_RS23320	COG1653	transport
FY148_RS23325	COG1175	transmembrane transport
FY148_RS23330	COG0395	ABC-type sugar transport system, permease component
FY148_RS23335	COG3842	ATPase activity
FY148_RS23345	COG0673	inositol 2-dehydrogenase activity
FY148_RS23375	COG0587	DNA-directed DNA polymerase activity
FY148_RS23380	COG2226	methyltransferase
FY148_RS23395	COG2186	Transcriptional regulator
FY148_RS23400	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS23405	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS23410	COG1129	ABC transporter
FY148_RS23415	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS23420	COG0129	dihydroxy-acid dehydratase activity
FY148_RS23430	COG0346	lactoylglutathione lyase activity
FY148_RS23445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY148_RS23450	COG4608	Belongs to the ABC transporter superfamily
FY148_RS23460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS23465	COG0601	transmembrane transport
FY148_RS23470	COG0747	negative chemotaxis
FY148_RS23480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY148_RS23485	COG5001	Diguanylate cyclase
FY148_RS23495	COG3257	ureidoglycine aminohydrolase activity
FY148_RS23505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS23510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY148_RS23520	COG1129	ABC transporter
FY148_RS23525	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS23530	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS23535	COG0583	DNA-binding transcription factor activity
FY148_RS23560	COG3047	cAMP biosynthetic process
FY148_RS23570	COG3842	ATPase activity
FY148_RS23575	COG0395	ABC-type sugar transport system, permease component
FY148_RS23580	COG1175	transmembrane transport
FY148_RS23585	COG1653	transport
FY148_RS23590	COG0523	cobalamin synthesis protein
FY148_RS23605	COG0523	cobalamin synthesis protein
FY148_RS23610	COG1121	(ABC) transporter
FY148_RS23620	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY148_RS23625	COG0454	-acetyltransferase
FY148_RS23640	COG0626	cystathionine gamma-synthase activity
FY148_RS23645	COG2182	Extracellular solute-binding protein
FY148_RS23655	COG0395	ABC-type sugar transport system, permease component
FY148_RS23670	COG0395	ABC-type sugar transport system, permease component
FY148_RS23675	COG1175	transmembrane transport
FY148_RS23680	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY148_RS23685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY148_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS23700	COG1063	alcohol dehydrogenase
FY148_RS23705	COG1609	Transcriptional regulator
FY148_RS23710	COG2223	nitrite transmembrane transporter activity
FY148_RS23715	COG4977	sequence-specific DNA binding
FY148_RS23745	COG0667	Aldo Keto reductase
FY148_RS23760	COG2186	Transcriptional regulator
FY148_RS23765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY148_RS23770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY148_RS23775	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS23780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY148_RS23785	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS23790	COG3618	amidohydrolase
FY148_RS23800	COG1175	transmembrane transport
FY148_RS23805	COG0395	ABC-type sugar transport system, permease component
FY148_RS23810	COG3842	ATPase activity
FY148_RS23825	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY148_RS23830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY148_RS23855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY148_RS23865	COG1278	Cold shock
FY148_RS23875	COG0673	inositol 2-dehydrogenase activity
FY148_RS23890	COG0673	inositol 2-dehydrogenase activity
FY148_RS23895	COG1309	transcriptional regulator
FY148_RS23900	COG1653	transport
FY148_RS23905	COG1175	transmembrane transport
FY148_RS23910	COG0395	ABC-type sugar transport system, permease component
FY148_RS23915	COG3842	ATPase activity
FY148_RS23920	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS23935	COG1609	Transcriptional regulator
FY148_RS23965	COG1175	transmembrane transport
FY148_RS23970	COG0395	ABC-type sugar transport system, permease component
FY148_RS23975	COG1116	anion transmembrane transporter activity
FY148_RS23980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY148_RS23985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY148_RS24000	COG3842	ATPase activity
FY148_RS24005	COG0395	ABC-type sugar transport system, permease component
FY148_RS24015	COG1653	transport
FY148_RS24050	COG3842	ATPase activity
FY148_RS24060	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS24065	COG0395	ABC-type sugar transport system, permease component
FY148_RS24125	COG2233	PERMEase
FY148_RS24140	COG5002	protein histidine kinase activity
FY148_RS24145	COG0745	RESPONSE REGULATOR receiver
FY148_RS24150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY148_RS24155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY148_RS24160	COG0702	epimerase
FY148_RS24170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY148_RS24205	COG2235	arginine
FY148_RS24215	COG0628	permease
FY148_RS24235	COG1522	sequence-specific DNA binding
FY148_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS24270	COG1414	Transcriptional regulator
FY148_RS24280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY148_RS24285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY148_RS24285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY148_RS24300	COG2140	Oxalate decarboxylase
FY148_RS24310	COG4566	intracellular signal transduction
FY148_RS24315	COG4566	intracellular signal transduction
FY148_RS24325	COG0243	molybdopterin cofactor binding
FY148_RS24330	COG0783	Belongs to the Dps family
FY148_RS24350	COG0596	Alpha beta hydrolase
FY148_RS24360	COG1764	response to oxidative stress
FY148_RS24375	COG0596	Alpha beta hydrolase
FY148_RS24385	COG0785	Cytochrome C biogenesis protein
FY148_RS24385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY148_RS24410	COG4172	Belongs to the ABC transporter superfamily
FY148_RS24430	COG0747	negative chemotaxis
FY148_RS24435	COG0601	transmembrane transport
FY148_RS24440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS24445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS24455	COG4106	trans-aconitate 2-methyltransferase activity
FY148_RS24460	COG0025	NhaP-type Na H and K H
FY148_RS24465	COG4302	ethanolamine ammonia-lyase activity
FY148_RS24490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY148_RS24495	COG1349	DNA-binding transcription factor activity
FY148_RS24500	COG4608	Belongs to the ABC transporter superfamily
FY148_RS24510	COG0601	transmembrane transport
FY148_RS24515	COG0747	negative chemotaxis
FY148_RS24520	COG1454	alcohol dehydrogenase
FY148_RS24525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY148_RS24530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY148_RS24535	COG0411	ABC transporter
FY148_RS24575	COG1192	Involved in chromosome partitioning
FY148_RS24580	COG1475	DNA binding
FY148_RS24585	COG0640	Transcriptional regulator
FY148_RS24600	COG1126	abc transporter atp-binding protein
FY148_RS24610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY148_RS24615	COG1609	Transcriptional regulator
FY148_RS24650	COG3239	Fatty acid desaturase
FY148_RS24660	COG1278	Cold shock
FY148_RS24740	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY148_RS24740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY148_RS24780	COG4191	Histidine kinase
FY148_RS24795	COG0640	Transcriptional regulator
FY148_RS24825	COG4977	sequence-specific DNA binding
FY148_RS24830	COG2211	Major facilitator Superfamily
FY148_RS24835	COG2807	transmembrane transport
FY148_RS24840	COG1846	Transcriptional regulator
FY148_RS24855	COG2814	Major facilitator Superfamily
FY148_RS24885	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY148_RS24900	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY148_RS24905	COG0583	DNA-binding transcription factor activity
FY148_RS24920	COG0071	Belongs to the small heat shock protein (HSP20) family
FY148_RS24970	COG3838	Conjugal transfer protein Trbc
FY148_RS24975	COG3702	type iv secretory pathway
FY148_RS24980	COG3451	type IV secretory pathway VirB4
FY148_RS24995	COG3704	protein secretion by the type IV secretion system
FY148_RS25005	COG3736	Type IV secretory pathway, component VirB8
FY148_RS25010	COG3504	Conjugal transfer protein
FY148_RS25015	COG2948	multi-organism process
FY148_RS25020	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY148_RS25125	COG3831	ATPase activity
FY148_RS25140	COG3505	Type IV secretory pathway VirD4
FY148_RS25165	COG0583	DNA-binding transcription factor activity
FY148_RS25210	COG0745	RESPONSE REGULATOR receiver
FY148_RS25250	COG3842	ATPase activity
FY148_RS25255	COG4208	sulfate ABC transporter
FY148_RS25260	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS25280	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY148_RS25285	COG1942	4-Oxalocrotonate Tautomerase
FY148_RS25295	COG3971	2-oxopent-4-enoate hydratase activity
FY148_RS25305	COG1414	Transcriptional regulator
FY148_RS25315	COG1137	ATPase activity
FY148_RS25330	COG4177	L-phenylalanine transmembrane transporter activity
FY148_RS25350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY148_RS25355	COG1175	transmembrane transport
FY148_RS25360	COG0395	ABC-type sugar transport system, permease component
FY148_RS25370	COG0366	Alpha amylase catalytic
FY148_RS25375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY148_RS25380	COG1082	Xylose isomerase domain protein TIM barrel
FY148_RS25385	COG3842	ATPase activity
FY148_RS25395	COG1940	carbohydrate kinase activity
FY148_RS25400	COG0395	ABC-type sugar transport system, permease component
FY148_RS25410	COG2182	Extracellular solute-binding protein
FY148_RS25415	COG0673	inositol 2-dehydrogenase activity
FY148_RS25445	COG1126	abc transporter atp-binding protein
FY148_RS25450	COG0765	amino acid transport
FY148_RS25455	COG0765	amino acid transport
FY148_RS25465	COG4608	Belongs to the ABC transporter superfamily
FY148_RS25475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS25490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY148_RS25495	COG0583	DNA-binding transcription factor activity
FY148_RS25500	COG2423	ornithine cyclodeaminase activity
FY148_RS25510	COG1957	nucleoside hydrolase
FY148_RS25515	COG1309	transcriptional regulator
FY148_RS25525	COG1335	isochorismatase
FY148_RS25530	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS25535	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS25580	COG0583	DNA-binding transcription factor activity
FY148_RS25585	COG1902	pentaerythritol trinitrate reductase activity
FY148_RS25590	COG0583	DNA-binding transcription factor activity
FY148_RS25595	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS25605	COG1335	isochorismatase
FY148_RS25610	COG0583	DNA-binding transcription factor activity
FY148_RS25620	COG1695	Transcriptional regulator
FY148_RS25705	COG2207	Transcriptional regulator
FY148_RS25765	COG1802	Transcriptional regulator
FY148_RS25770	COG3485	protocatechuate 3,4-dioxygenase
FY148_RS25775	COG3971	2-oxopent-4-enoate hydratase activity
FY148_RS25790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY148_RS25795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY148_RS25810	COG1063	alcohol dehydrogenase
FY148_RS25820	COG1960	acyl-CoA dehydrogenase activity
FY148_RS25825	COG1024	Enoyl-CoA hydratase
FY148_RS25835	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS25840	COG0477	Major facilitator Superfamily
FY148_RS25855	COG3706	GGDEF domain
FY148_RS25875	COG1846	Transcriptional regulator
FY148_RS25915	COG1012	belongs to the aldehyde dehydrogenase family
FY148_RS25925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY148_RS25935	COG3386	PFAM SMP-30 Gluconolaconase
FY148_RS25940	COG3622	Belongs to the hyi family
FY148_RS25945	COG2084	Dehydrogenase
FY148_RS25970	COG1940	carbohydrate kinase activity
FY148_RS25975	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS25985	COG1129	ABC transporter
FY148_RS26005	COG0583	DNA-binding transcription factor activity
FY148_RS26010	COG2271	Major facilitator Superfamily
FY148_RS26020	COG2272	Belongs to the type-B carboxylesterase lipase family
FY148_RS26040	COG1129	ABC transporter
FY148_RS26065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY148_RS26075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY148_RS26110	COG0583	DNA-binding transcription factor activity
FY148_RS26115	COG1414	Transcriptional regulator
FY148_RS26125	COG4948	Mandelate Racemase Muconate Lactonizing
FY148_RS26135	COG3842	ATPase activity
FY148_RS26140	COG1175	transmembrane transport
FY148_RS26145	COG0395	ABC-type sugar transport system, permease component
FY148_RS26155	COG0477	Major facilitator Superfamily
FY148_RS26190	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY148_RS26205	COG0583	DNA-binding transcription factor activity
FY148_RS26210	COG0747	negative chemotaxis
FY148_RS26220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS26235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY148_RS26245	COG4215	(ABC) transporter
FY148_RS26300	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY148_RS26305	COG0251	oxidation-reduction process
FY148_RS26340	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS26345	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS26350	COG1335	isochorismatase
FY148_RS26360	COG1309	transcriptional regulator
FY148_RS26365	COG4604	ABC transporter, ATP-binding protein
FY148_RS26370	COG4605	iron ion homeostasis
FY148_RS26375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY148_RS26385	COG2132	Multicopper oxidase
FY148_RS26390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY148_RS26440	COG1695	Transcriptional regulator
FY148_RS26475	COG2132	Multicopper oxidase
FY148_RS26510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY148_RS26530	COG1192	Involved in chromosome partitioning
FY148_RS26535	COG1475	DNA binding
FY148_RS26540	COG0640	Transcriptional regulator
FY148_RS26545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY148_RS26575	COG2211	Major facilitator Superfamily
FY148_RS26625	COG1051	belongs to the nudix hydrolase family
FY148_RS26670	COG1475	DNA binding
FY148_RS26695	COG2824	Alkylphosphonate utilization operon protein PhnA
FY148_RS26715	COG1280	lysine exporter protein (LysE YggA)
FY148_RS26730	COG5489	Protein of unknown function (DUF736)
FY148_RS26795	COG1879	ABC-type sugar transport system periplasmic component
FY148_RS26800	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY148_RS26820	COG1280	lysine exporter protein (LysE YggA)
FY148_RS26905	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY148_RS26920	COG0747	negative chemotaxis
FY148_RS26925	COG0444	Belongs to the ABC transporter superfamily
FY148_RS26940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS26945	COG0584	glycerophosphoryl diester phosphodiesterase
FY148_RS26950	COG0483	inositol monophosphate 1-phosphatase activity
FY148_RS27015	COG3161	chorismate lyase activity
FY148_RS27240	COG2222	sugar isomerase
FY148_RS27250	COG0006	proline dipeptidase activity
FY148_RS27270	COG1177	transmembrane transport
FY148_RS27275	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY148_RS27280	COG3842	ATPase activity
FY148_RS27310	COG3842	ATPase activity
FY148_RS27315	COG0006	proline dipeptidase activity
FY148_RS27335	COG0300	oxidoreductase activity
FY148_RS27340	COG0129	dihydroxy-acid dehydratase activity
FY148_RS27345	COG0667	Aldo Keto reductase
FY148_RS27355	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS27365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS27370	COG0601	transmembrane transport
FY148_RS27375	COG4172	Belongs to the ABC transporter superfamily
FY148_RS27385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY148_RS27420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY148_RS27455	COG3701	Conjugal transfer protein
FY148_RS27460	COG3846	protein secretion by the type IV secretion system
FY148_RS27470	COG5314	conjugation
FY148_RS27475	COG3451	type IV secretory pathway VirB4
FY148_RS27490	COG4962	Type ii secretion system protein e
FY148_RS27550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY148_RS27565	COG0469	pyruvate kinase activity
FY148_RS27575	COG0574	Belongs to the PEP-utilizing enzyme family
FY148_RS27575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY148_RS27585	COG1028	Short-chain dehydrogenase reductase Sdr
FY148_RS27600	COG1619	proteins homologs of microcin C7 resistance protein MccF
FY148_RS27610	COG2226	methyltransferase
FY148_RS27630	COG0495	leucyl-tRNA aminoacylation
FY148_RS27645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY148_RS27655	COG1132	(ABC) transporter
FY148_RS27685	COG1475	DNA binding