locus-tag	class	description
H1Y61_RS00010	COG0071	Belongs to the small heat shock protein (HSP20) family
H1Y61_RS00020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1Y61_RS00025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H1Y61_RS00030	COG1396	sequence-specific DNA binding
H1Y61_RS00035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H1Y61_RS00040	COG4535	Mg2 and Co2 transporter CorC
H1Y61_RS00045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H1Y61_RS00050	COG1702	phosphate starvation-inducible protein PhoH
H1Y61_RS00055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1Y61_RS00075	COG1214	PFAM Peptidase M22, glycoprotease
H1Y61_RS00080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H1Y61_RS00090	COG0180	Tryptophanyl-tRNA synthetase
H1Y61_RS00095	COG0346	lactoylglutathione lyase activity
H1Y61_RS00105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H1Y61_RS00110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1Y61_RS00115	COG0583	DNA-binding transcription factor activity
H1Y61_RS00130	COG2205	protein histidine kinase activity
H1Y61_RS00130	COG3437	response regulator, receiver
H1Y61_RS00130	COG4999	Histidine kinase
H1Y61_RS00130	COG3850	Histidine kinase
H1Y61_RS00135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H1Y61_RS00140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Y61_RS00145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H1Y61_RS00145	COG0116	Belongs to the methyltransferase superfamily
H1Y61_RS00155	COG0776	regulation of translation
H1Y61_RS00165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1Y61_RS00170	COG1137	ATPase activity
H1Y61_RS00180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H1Y61_RS00185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Y61_RS00190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H1Y61_RS00195	COG1420	regulation of RNA biosynthetic process
H1Y61_RS00200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H1Y61_RS00210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H1Y61_RS00215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1Y61_RS00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1Y61_RS00225	COG0697	spore germination
H1Y61_RS00230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H1Y61_RS00235	COG0268	Binds directly to 16S ribosomal RNA
H1Y61_RS00240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H1Y61_RS00245	COG2226	methyltransferase
H1Y61_RS00250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1Y61_RS00255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Y61_RS00255	COG2198	Histidine kinase
H1Y61_RS00255	COG0784	Response regulator, receiver
H1Y61_RS00255	COG2205	protein histidine kinase activity
H1Y61_RS00260	COG0784	Response regulator, receiver
H1Y61_RS00265	COG3920	Histidine kinase
H1Y61_RS00270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1Y61_RS00285	COG0583	DNA-binding transcription factor activity
H1Y61_RS00300	COG1741	Belongs to the pirin family
H1Y61_RS00320	COG1877	trehalose-phosphatase activity
H1Y61_RS00325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1Y61_RS00330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1Y61_RS00335	COG0756	dUTP diphosphatase activity
H1Y61_RS00340	COG1280	lysine exporter protein (LysE YggA)
H1Y61_RS00355	COG0606	chelatase, subunit chli
H1Y61_RS00360	COG0189	ligase activity
H1Y61_RS00370	COG3842	ATPase activity
H1Y61_RS00375	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS00380	COG1175	transmembrane transport
H1Y61_RS00385	COG1653	transport
H1Y61_RS00390	COG0792	nuclease activity
H1Y61_RS00395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1Y61_RS00405	COG3963	phosphatidate phosphatase activity
H1Y61_RS00415	COG0284	orotidine-5'-phosphate decarboxylase activity
H1Y61_RS00435	COG1968	undecaprenyl-diphosphatase activity
H1Y61_RS00445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1Y61_RS00455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1Y61_RS00460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Y61_RS00460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1Y61_RS00500	COG0519	Catalyzes the synthesis of GMP from XMP
H1Y61_RS00500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1Y61_RS00530	COG3002	Belongs to the UPF0753 family
H1Y61_RS00535	COG5001	Diguanylate cyclase
H1Y61_RS00535	COG3300	MHYT domain
H1Y61_RS00540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Y61_RS00550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Y61_RS00565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1Y61_RS00570	COG2900	Belongs to the SlyX family
H1Y61_RS00575	COG0484	heat shock protein binding
H1Y61_RS00585	COG0443	Heat shock 70 kDa protein
H1Y61_RS00590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1Y61_RS00600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1Y61_RS00605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Y61_RS00615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1Y61_RS00615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1Y61_RS00620	COG0791	NLP P60 protein
H1Y61_RS00630	COG2353	YceI-like domain
H1Y61_RS00635	COG2353	YceI-like domain
H1Y61_RS00640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1Y61_RS00655	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1Y61_RS00660	COG3454	Phosphonate metabolism
H1Y61_RS00665	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1Y61_RS00670	COG3639	organic phosphonate transmembrane transporter activity
H1Y61_RS00680	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H1Y61_RS00685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H1Y61_RS00695	COG4778	phosphonate C-P lyase system protein PhnL
H1Y61_RS00700	COG4107	phosphonate C-P lyase system protein PhnK
H1Y61_RS00705	COG3627	carbon phosphorus lyase activity
H1Y61_RS00710	COG3626	phosphonate metabolism
H1Y61_RS00715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H1Y61_RS00720	COG3624	Phosphonate C-P lyase system protein PhnG
H1Y61_RS00725	COG2188	Transcriptional regulator
H1Y61_RS00730	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H1Y61_RS00735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H1Y61_RS00785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H1Y61_RS00795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Y61_RS00800	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS00805	COG4239	(ABC) transporter, permease
H1Y61_RS00810	COG4174	ABC transporter (Permease)
H1Y61_RS00815	COG4166	transmembrane transport
H1Y61_RS00820	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H1Y61_RS00825	COG1803	Methylglyoxal synthase
H1Y61_RS00830	COG0837	glucose binding
H1Y61_RS00835	COG1132	(ABC) transporter
H1Y61_RS00840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H1Y61_RS00845	COG0588	phosphoglycerate mutase activity
H1Y61_RS00855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H1Y61_RS00860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1Y61_RS00865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H1Y61_RS00905	COG4964	Belongs to the GSP D family
H1Y61_RS00950	COG0072	phenylalanine-tRNA ligase activity
H1Y61_RS00950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Y61_RS00975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H1Y61_RS00980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H1Y61_RS00985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H1Y61_RS00990	COG2205	protein histidine kinase activity
H1Y61_RS00995	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS01000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H1Y61_RS01020	COG0539	negative regulation of cytoplasmic translation
H1Y61_RS01025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H1Y61_RS01050	COG2860	membrane
H1Y61_RS01060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Y61_RS01070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1Y61_RS01075	COG2813	Specifically methylates the guanine in position
H1Y61_RS01080	COG1185	polyribonucleotide nucleotidyltransferase activity
H1Y61_RS01085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H1Y61_RS01090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1Y61_RS01095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H1Y61_RS01100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H1Y61_RS01110	COG0195	Participates in both transcription termination and antitermination
H1Y61_RS01110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1Y61_RS01115	COG0779	Required for maturation of 30S ribosomal subunits
H1Y61_RS01120	COG2814	Major facilitator Superfamily
H1Y61_RS01145	COG2951	lytic endotransglycosylase activity
H1Y61_RS01150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1Y61_RS01170	COG0667	Aldo Keto reductase
H1Y61_RS01210	COG1570	exodeoxyribonuclease VII activity
H1Y61_RS01215	COG1278	Cold shock
H1Y61_RS01230	COG2309	aminopeptidase activity
H1Y61_RS01235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1Y61_RS01240	COG1393	Belongs to the ArsC family
H1Y61_RS01265	COG1607	acyl-coa hydrolase
H1Y61_RS01270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1Y61_RS01285	COG0481	GTPase activity
H1Y61_RS01290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1Y61_RS01305	COG3422	double-strand break repair
H1Y61_RS01315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H1Y61_RS01320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1Y61_RS01335	COG2816	NAD+ diphosphatase activity
H1Y61_RS01345	COG0077	Prephenate dehydratase
H1Y61_RS01345	COG1605	Chorismate mutase
H1Y61_RS01350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H1Y61_RS01355	COG3474	cytochrome
H1Y61_RS01370	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS01380	COG3842	ATPase activity
H1Y61_RS01385	COG3842	ATPase activity
H1Y61_RS01405	COG3806	Anti-sigma factor
H1Y61_RS01410	COG1595	DNA-templated transcription, initiation
H1Y61_RS01425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Y61_RS01430	COG4221	oxidoreductase activity
H1Y61_RS01455	COG3718	enzyme involved in inositol metabolism
H1Y61_RS01470	COG3962	Belongs to the TPP enzyme family
H1Y61_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Y61_RS01485	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS01495	COG1609	Transcriptional regulator
H1Y61_RS01500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS01505	COG2814	Major facilitator Superfamily
H1Y61_RS01555	COG2423	ornithine cyclodeaminase activity
H1Y61_RS01560	COG1643	Atp-dependent helicase
H1Y61_RS01570	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H1Y61_RS01585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1Y61_RS01590	COG1074	ATP-dependent DNA helicase activity
H1Y61_RS01595	COG2887	Belongs to the helicase family. UvrD subfamily
H1Y61_RS01600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1Y61_RS01605	COG3178	'Phosphotransferase
H1Y61_RS01610	COG2205	protein histidine kinase activity
H1Y61_RS01615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1Y61_RS01620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Y61_RS01625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1Y61_RS01625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Y61_RS01635	COG0642	Histidine kinase
H1Y61_RS01640	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS01645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H1Y61_RS01660	COG1072	(Pantothenic acid kinase))
H1Y61_RS01665	COG0140	phosphoribosyl-ATP diphosphatase activity
H1Y61_RS01670	COG0107	imidazoleglycerol-phosphate synthase activity
H1Y61_RS01675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H1Y61_RS01680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1Y61_RS01685	COG0131	Imidazoleglycerol-phosphate dehydratase
H1Y61_RS01690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H1Y61_RS01695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H1Y61_RS01720	COG0285	dihydrofolate synthase activity
H1Y61_RS01725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H1Y61_RS01730	COG0159	tryptophan synthase activity
H1Y61_RS01735	COG0133	tryptophan synthase activity
H1Y61_RS01740	COG0135	phosphoribosylanthranilate isomerase activity
H1Y61_RS01780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H1Y61_RS01795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H1Y61_RS01805	COG0237	dephospho-CoA kinase activity
H1Y61_RS01810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1Y61_RS01815	COG0424	maF-like protein
H1Y61_RS01820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H1Y61_RS01825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H1Y61_RS01835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H1Y61_RS01840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H1Y61_RS01845	COG0445	tRNA wobble uridine modification
H1Y61_RS01850	COG0357	Ribosomal RNA small subunit methyltransferase G
H1Y61_RS01875	COG0495	leucyl-tRNA aminoacylation
H1Y61_RS01880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H1Y61_RS01890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1Y61_RS01900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H1Y61_RS01915	COG1473	amidohydrolase
H1Y61_RS01920	COG3459	Glycosyltransferase 36 associated
H1Y61_RS01935	COG2902	Dehydrogenase
H1Y61_RS01940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H1Y61_RS01945	COG0288	reversible hydration of carbon dioxide
H1Y61_RS01950	COG2010	Cytochrome c
H1Y61_RS01960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1Y61_RS01970	COG0671	phosphoesterase, PA-phosphatase related
H1Y61_RS01975	COG0473	3-isopropylmalate dehydrogenase activity
H1Y61_RS01980	COG0066	3-isopropylmalate dehydratase activity
H1Y61_RS02010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1Y61_RS02045	COG0183	Belongs to the thiolase family
H1Y61_RS02050	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H1Y61_RS02055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H1Y61_RS02065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1Y61_RS02070	COG0142	geranyltranstransferase activity
H1Y61_RS02080	COG2885	chlorophyll binding
H1Y61_RS02085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H1Y61_RS02090	COG0738	Major facilitator superfamily
H1Y61_RS02105	COG4221	oxidoreductase activity
H1Y61_RS02120	COG1522	sequence-specific DNA binding
H1Y61_RS02145	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS02150	COG2198	Histidine kinase
H1Y61_RS02150	COG0643	Histidine kinase
H1Y61_RS02155	COG0835	chemotaxis
H1Y61_RS02160	COG0840	transmembrane signaling receptor activity
H1Y61_RS02165	COG0840	transmembrane signaling receptor activity
H1Y61_RS02165	COG3290	protein histidine kinase activity
H1Y61_RS02170	COG0840	transmembrane signaling receptor activity
H1Y61_RS02175	COG0835	chemotaxis
H1Y61_RS02180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Y61_RS02185	COG2201	protein-glutamate methylesterase activity
H1Y61_RS02210	COG1192	Involved in chromosome partitioning
H1Y61_RS02215	COG0494	nUDIX hydrolase
H1Y61_RS02225	COG0793	Belongs to the peptidase S41A family
H1Y61_RS02240	COG0501	Belongs to the peptidase M48B family
H1Y61_RS02245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Y61_RS02245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1Y61_RS02255	COG0138	bifunctional purine biosynthesis protein purh
H1Y61_RS02275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H1Y61_RS02280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H1Y61_RS02300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H1Y61_RS02305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H1Y61_RS02310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H1Y61_RS02315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H1Y61_RS02320	COG0799	negative regulation of ribosome biogenesis
H1Y61_RS02325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H1Y61_RS02355	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H1Y61_RS02395	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1Y61_RS02405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1Y61_RS02410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H1Y61_RS02425	COG2017	converts alpha-aldose to the beta-anomer
H1Y61_RS02445	COG3118	belongs to the thioredoxin family
H1Y61_RS02450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1Y61_RS02455	COG2835	tetraacyldisaccharide 4'-kinase activity
H1Y61_RS02460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Y61_RS02465	COG1946	Acyl-CoA thioesterase
H1Y61_RS02470	COG0347	Belongs to the P(II) protein family
H1Y61_RS02475	COG0004	ammonium transporteR
H1Y61_RS02480	COG1674	ftsk spoiiie
H1Y61_RS02485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1Y61_RS02505	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS02520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H1Y61_RS02535	COG0765	amino acid transport
H1Y61_RS02545	COG2372	response to copper ion
H1Y61_RS02545	COG1276	copper resistance
H1Y61_RS02550	COG2372	response to copper ion
H1Y61_RS02565	COG0335	large ribosomal subunit rRNA binding
H1Y61_RS02575	COG0336	Belongs to the RNA methyltransferase TrmD family
H1Y61_RS02580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1Y61_RS02585	COG0228	four-way junction DNA binding
H1Y61_RS02590	COG1605	Chorismate mutase
H1Y61_RS02590	COG0287	Prephenate dehydrogenase
H1Y61_RS02595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1Y61_RS02610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H1Y61_RS02615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1Y61_RS02620	COG0552	protein localization to endoplasmic reticulum
H1Y61_RS02625	COG2917	probably involved in intracellular septation
H1Y61_RS02645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1Y61_RS02650	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1Y61_RS02655	COG4133	protoheme IX ABC transporter activity
H1Y61_RS02660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1Y61_RS02680	COG0670	Belongs to the BI1 family
H1Y61_RS02685	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1Y61_RS02690	COG1136	(ABC) transporter
H1Y61_RS02700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H1Y61_RS02705	COG2154	pterin-4-alpha-carbinolamine dehydratase
H1Y61_RS02720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H1Y61_RS02730	COG1280	lysine exporter protein (LysE YggA)
H1Y61_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS02745	COG0137	argininosuccinate synthase activity
H1Y61_RS02765	COG0339	signal peptide processing
H1Y61_RS02785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1Y61_RS02790	COG1872	DUF167
H1Y61_RS02830	COG0181	hydroxymethylbilane synthase activity
H1Y61_RS02835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H1Y61_RS02840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H1Y61_RS02845	COG2350	Protein conserved in bacteria
H1Y61_RS02855	COG2264	protein methyltransferase activity
H1Y61_RS02890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1Y61_RS02895	COG0039	L-malate dehydrogenase activity
H1Y61_RS02900	COG0045	succinate-CoA ligase (ADP-forming) activity
H1Y61_RS02910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H1Y61_RS02920	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Y61_RS02945	COG4974	Belongs to the 'phage' integrase family
H1Y61_RS02950	COG0840	transmembrane signaling receptor activity
H1Y61_RS02950	COG2972	Histidine kinase
H1Y61_RS02965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1Y61_RS02970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H1Y61_RS02975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H1Y61_RS02980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H1Y61_RS02985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H1Y61_RS02990	COG0039	L-malate dehydrogenase activity
H1Y61_RS02995	COG0640	Transcriptional regulator
H1Y61_RS03015	COG3383	formate dehydrogenase (NAD+) activity
H1Y61_RS03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1Y61_RS03030	COG2223	nitrite transmembrane transporter activity
H1Y61_RS03035	COG0835	chemotaxis
H1Y61_RS03050	COG0729	surface antigen
H1Y61_RS03060	COG0156	8-amino-7-oxononanoate synthase activity
H1Y61_RS03070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H1Y61_RS03080	COG0840	transmembrane signaling receptor activity
H1Y61_RS03090	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS03095	COG0643	Histidine kinase
H1Y61_RS03095	COG2198	Histidine kinase
H1Y61_RS03100	COG0835	chemotaxis
H1Y61_RS03105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Y61_RS03110	COG2201	protein-glutamate methylesterase activity
H1Y61_RS03115	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS03120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H1Y61_RS03130	COG1766	The M ring may be actively involved in energy transduction
H1Y61_RS03135	COG2771	luxR family
H1Y61_RS03145	COG0628	permease
H1Y61_RS03155	COG1473	amidohydrolase
H1Y61_RS03160	COG1686	Belongs to the peptidase S11 family
H1Y61_RS03165	COG0523	cobalamin synthesis protein
H1Y61_RS03175	COG3034	peptidoglycan biosynthetic process
H1Y61_RS03180	COG0825	malonyl-CoA metabolic process
H1Y61_RS03185	COG4974	Belongs to the 'phage' integrase family
H1Y61_RS03195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1Y61_RS03200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H1Y61_RS03230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H1Y61_RS03235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H1Y61_RS03260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Y61_RS03265	COG2226	methyltransferase
H1Y61_RS03270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Y61_RS03275	COG0287	Prephenate dehydrogenase
H1Y61_RS03285	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H1Y61_RS03305	COG2884	Cell division ATP-binding protein ftsE
H1Y61_RS03340	COG0165	Argininosuccinate lyase
H1Y61_RS03345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1Y61_RS03350	COG0625	glutathione transferase activity
H1Y61_RS03355	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1Y61_RS03360	COG0840	transmembrane signaling receptor activity
H1Y61_RS03360	COG2972	Histidine kinase
H1Y61_RS03370	COG2086	electron transfer activity
H1Y61_RS03385	COG0300	oxidoreductase activity
H1Y61_RS03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1Y61_RS03440	COG0667	Aldo Keto reductase
H1Y61_RS03470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1Y61_RS03485	COG0653	protein targeting
H1Y61_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1Y61_RS03495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1Y61_RS03505	COG0494	nUDIX hydrolase
H1Y61_RS03520	COG2226	methyltransferase
H1Y61_RS03530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1Y61_RS03535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1Y61_RS03550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1Y61_RS03565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H1Y61_RS03565	COG0392	lysyltransferase activity
H1Y61_RS03570	COG0527	aspartate kinase activity
H1Y61_RS03580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H1Y61_RS03585	COG2890	protein-(glutamine-N5) methyltransferase activity
H1Y61_RS03595	COG0542	response to heat
H1Y61_RS03640	COG0469	pyruvate kinase activity
H1Y61_RS03645	COG3206	protein involved in exopolysaccharide biosynthesis
H1Y61_RS03645	COG0489	protein tyrosine kinase activity
H1Y61_RS03650	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS03655	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS03660	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS03665	COG0438	transferase activity, transferring glycosyl groups
H1Y61_RS03670	COG2273	Hydrolase Family 16
H1Y61_RS03675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H1Y61_RS03680	COG2244	polysaccharide biosynthetic process
H1Y61_RS03685	COG0463	Glycosyl transferase, family 2
H1Y61_RS03690	COG2327	Polysaccharide pyruvyl transferase
H1Y61_RS03695	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS03705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1Y61_RS03710	COG1596	polysaccharide export
H1Y61_RS03715	COG3307	-O-antigen
H1Y61_RS03735	COG0400	carboxylic ester hydrolase activity
H1Y61_RS03740	COG0346	lactoylglutathione lyase activity
H1Y61_RS03765	COG1289	transmembrane transporter activity
H1Y61_RS03785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H1Y61_RS03795	COG2986	histidine ammonia-lyase
H1Y61_RS03800	COG1228	amidohydrolase
H1Y61_RS03805	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS03820	COG4598	ABC transporter
H1Y61_RS03825	COG0765	amino acid transport
H1Y61_RS03830	COG0765	amino acid transport
H1Y61_RS03840	COG1072	(Pantothenic acid kinase))
H1Y61_RS03860	COG1940	carbohydrate kinase activity
H1Y61_RS03880	COG0010	Belongs to the arginase family
H1Y61_RS03895	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Y61_RS03905	COG0848	biopolymer transport protein
H1Y61_RS03920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Y61_RS03960	COG0784	Response regulator, receiver
H1Y61_RS03970	COG0783	Belongs to the Dps family
H1Y61_RS03990	COG1793	dna ligase
H1Y61_RS04000	COG0789	Transcriptional regulator
H1Y61_RS04010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS04020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H1Y61_RS04035	COG0438	transferase activity, transferring glycosyl groups
H1Y61_RS04065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1Y61_RS04075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS04085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1Y61_RS04090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H1Y61_RS04100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS04105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS04115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1Y61_RS04170	COG0840	transmembrane signaling receptor activity
H1Y61_RS04175	COG0419	ATPase involved in DNA repair
H1Y61_RS04205	COG0438	transferase activity, transferring glycosyl groups
H1Y61_RS04230	COG0601	transmembrane transport
H1Y61_RS04235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS04245	COG0438	transferase activity, transferring glycosyl groups
H1Y61_RS04250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1Y61_RS04255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Y61_RS04260	COG0840	transmembrane signaling receptor activity
H1Y61_RS04260	COG2972	Histidine kinase
H1Y61_RS04265	COG4953	penicillin-binding protein 1C
H1Y61_RS04270	COG2373	Large extracellular alpha-helical protein
H1Y61_RS04275	COG2807	transmembrane transport
H1Y61_RS04280	COG2186	Transcriptional regulator
H1Y61_RS04285	COG0697	spore germination
H1Y61_RS04290	COG2832	Protein of unknown function (DUF454)
H1Y61_RS04295	COG0800	Aldolase
H1Y61_RS04300	COG3734	2-keto-3-deoxy-galactonokinase
H1Y61_RS04315	COG0129	dihydroxy-acid dehydratase activity
H1Y61_RS04325	COG4214	carbohydrate transport
H1Y61_RS04335	COG4213	ABC transporter substrate-binding protein
H1Y61_RS04350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H1Y61_RS04355	COG2721	sulfolactate sulfo-lyase activity
H1Y61_RS04360	COG1312	Catalyzes the dehydration of D-mannonate
H1Y61_RS04365	COG0246	Mannitol dehydrogenase
H1Y61_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS04380	COG1917	Cupin 2, conserved barrel domain protein
H1Y61_RS04390	COG1904	glucuronate isomerase
H1Y61_RS04395	COG1802	Transcriptional regulator
H1Y61_RS04400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Y61_RS04410	COG0747	negative chemotaxis
H1Y61_RS04415	COG0601	transmembrane transport
H1Y61_RS04425	COG0444	Belongs to the ABC transporter superfamily
H1Y61_RS04435	COG3454	Phosphonate metabolism
H1Y61_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS04450	COG1129	ABC transporter
H1Y61_RS04450	COG0842	Transport permease protein
H1Y61_RS04455	COG0842	Transport permease protein
H1Y61_RS04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS04465	COG0601	transmembrane transport
H1Y61_RS04480	COG1473	amidohydrolase
H1Y61_RS04485	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS04520	COG2274	protein secretion by the type I secretion system
H1Y61_RS04535	COG3273	potassium ion transport
H1Y61_RS04535	COG0471	metal ion transport
H1Y61_RS04540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1Y61_RS04545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H1Y61_RS04565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1Y61_RS04595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1Y61_RS04615	COG1253	flavin adenine dinucleotide binding
H1Y61_RS04620	COG1309	transcriptional regulator
H1Y61_RS04635	COG1609	Transcriptional regulator
H1Y61_RS04640	COG1070	Carbohydrate kinase
H1Y61_RS04645	COG2115	Belongs to the xylose isomerase family
H1Y61_RS04655	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS04675	COG2199	diguanylate cyclase activity
H1Y61_RS04675	COG2200	EAL domain
H1Y61_RS04675	COG2202	Pas domain
H1Y61_RS04690	COG2378	regulation of single-species biofilm formation
H1Y61_RS04700	COG2954	triphosphatase activity
H1Y61_RS04735	COG0583	DNA-binding transcription factor activity
H1Y61_RS04760	COG3047	cAMP biosynthetic process
H1Y61_RS04765	COG0840	transmembrane signaling receptor activity
H1Y61_RS04775	COG0523	cobalamin synthesis protein
H1Y61_RS04785	COG1846	Transcriptional regulator
H1Y61_RS04790	COG1609	Transcriptional regulator
H1Y61_RS04795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Y61_RS04800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H1Y61_RS04805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H1Y61_RS04825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1Y61_RS04835	COG1733	regulation of RNA biosynthetic process
H1Y61_RS04850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Y61_RS04850	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1Y61_RS04860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS04865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1Y61_RS04900	COG1523	belongs to the glycosyl hydrolase 13 family
H1Y61_RS04905	COG0033	Phosphoglucomutase
H1Y61_RS04910	COG0297	glycogen (starch) synthase activity
H1Y61_RS04915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H1Y61_RS04920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Y61_RS04925	COG0058	SHG alpha-glucan phosphorylase activity
H1Y61_RS04945	COG2308	Evidence 4 Homologs of previously reported genes of
H1Y61_RS04945	COG2307	Protein conserved in bacteria
H1Y61_RS04955	COG0662	Cupin 2, conserved barrel domain protein
H1Y61_RS04955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H1Y61_RS04965	COG0419	ATPase involved in DNA repair
H1Y61_RS05000	COG0071	Belongs to the small heat shock protein (HSP20) family
H1Y61_RS05010	COG0070	glutamate synthase
H1Y61_RS05010	COG0069	glutamate synthase activity
H1Y61_RS05010	COG0067	glutamate synthase
H1Y61_RS05020	COG0840	transmembrane signaling receptor activity
H1Y61_RS05030	COG2951	lytic endotransglycosylase activity
H1Y61_RS05035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1Y61_RS05045	COG0517	IMP dehydrogenase activity
H1Y61_RS05045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1Y61_RS05055	COG0330	HflC and HflK could
H1Y61_RS05060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1Y61_RS05065	COG0720	synthase
H1Y61_RS05070	COG0602	queuosine metabolic process
H1Y61_RS05075	COG0840	transmembrane signaling receptor activity
H1Y61_RS05085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H1Y61_RS05090	COG0737	Belongs to the 5'-nucleotidase family
H1Y61_RS05100	COG5310	Homospermidine synthase
H1Y61_RS05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS05115	COG0512	Glutamine amidotransferase of anthranilate synthase
H1Y61_RS05115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1Y61_RS05135	COG0679	Auxin Efflux Carrier
H1Y61_RS05140	COG0583	DNA-binding transcription factor activity
H1Y61_RS05145	COG3750	Belongs to the UPF0335 family
H1Y61_RS05165	COG0469	pyruvate kinase activity
H1Y61_RS05170	COG0596	Alpha beta hydrolase
H1Y61_RS05175	COG0457	Tetratricopeptide repeat
H1Y61_RS05180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H1Y61_RS05185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1Y61_RS05190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H1Y61_RS05205	COG0640	Transcriptional regulator
H1Y61_RS05215	COG0352	thiamine-phosphate diphosphorylase activity
H1Y61_RS05225	COG0483	inositol monophosphate 1-phosphatase activity
H1Y61_RS05245	COG1132	(ABC) transporter
H1Y61_RS05250	COG0254	rRNA binding
H1Y61_RS05305	COG0384	phenazine biosynthesis protein PhzF
H1Y61_RS05310	COG3588	fructose-bisphosphate aldolase
H1Y61_RS05315	COG0126	phosphoglycerate kinase activity
H1Y61_RS05320	COG1692	metallophosphoesterase
H1Y61_RS05325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1Y61_RS05330	COG0840	transmembrane signaling receptor activity
H1Y61_RS05395	COG0217	transcriptional regulatory protein
H1Y61_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1Y61_RS05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1Y61_RS05410	COG0037	tRNA processing
H1Y61_RS05420	COG2885	chlorophyll binding
H1Y61_RS05425	COG0823	Involved in the tonB-independent uptake of proteins
H1Y61_RS05445	COG0824	Thioesterase
H1Y61_RS05460	COG0494	nUDIX hydrolase
H1Y61_RS05465	COG1408	metallophosphoesterase
H1Y61_RS05470	COG2255	four-way junction helicase activity
H1Y61_RS05480	COG2002	toxin-antitoxin pair type II binding
H1Y61_RS05485	COG0632	four-way junction helicase activity
H1Y61_RS05490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H1Y61_RS05495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS05520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Y61_RS05525	COG0840	transmembrane signaling receptor activity
H1Y61_RS05530	COG1271	oxidase subunit
H1Y61_RS05535	COG1294	oxidase, subunit
H1Y61_RS05565	COG4774	siderophore transport
H1Y61_RS05575	COG1120	ATPase activity
H1Y61_RS05595	COG4774	siderophore transport
H1Y61_RS05600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1Y61_RS05605	COG1122	ATPase activity
H1Y61_RS05740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1Y61_RS05750	COG5005	Phage virion morphogenesis
H1Y61_RS05805	COG4396	Host-nuclease inhibitor protein Gam
H1Y61_RS05865	COG0482	sulfurtransferase activity
H1Y61_RS05875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Y61_RS05900	COG1175	transmembrane transport
H1Y61_RS05935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H1Y61_RS05980	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS05990	COG1116	anion transmembrane transporter activity
H1Y61_RS06010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1Y61_RS06020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1Y61_RS06035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H1Y61_RS06050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1Y61_RS06055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS06055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1Y61_RS06060	COG0564	pseudouridine synthase activity
H1Y61_RS06070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Y61_RS06130	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1Y61_RS06140	COG2814	Major facilitator Superfamily
H1Y61_RS06185	COG0850	regulation of cytokinetic process
H1Y61_RS06190	COG2894	cell division
H1Y61_RS06195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H1Y61_RS06245	COG2205	protein histidine kinase activity
H1Y61_RS06245	COG0784	Response regulator, receiver
H1Y61_RS06255	COG4251	negative regulation of phosphorylation
H1Y61_RS06300	COG0829	nickel cation binding
H1Y61_RS06305	COG0831	urea catabolic process
H1Y61_RS06310	COG3813	Protein conserved in bacteria
H1Y61_RS06315	COG0832	Belongs to the urease beta subunit family
H1Y61_RS06320	COG3755	Protein conserved in bacteria
H1Y61_RS06325	COG1442	glycosyl transferase family 8
H1Y61_RS06330	COG0804	urea catabolic process
H1Y61_RS06350	COG5001	Diguanylate cyclase
H1Y61_RS06350	COG5002	protein histidine kinase activity
H1Y61_RS06355	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H1Y61_RS06360	COG0830	nickel cation binding
H1Y61_RS06365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H1Y61_RS06390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS06395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS06400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS06430	COG1309	transcriptional regulator
H1Y61_RS06450	COG0493	'glutamate synthase
H1Y61_RS06470	COG2346	COG2346, Truncated hemoglobins
H1Y61_RS06500	COG2308	Evidence 4 Homologs of previously reported genes of
H1Y61_RS06610	COG0250	Participates in transcription elongation, termination and antitermination
H1Y61_RS06630	COG3209	COG3209 Rhs family protein
H1Y61_RS06650	COG3501	Rhs element vgr protein
H1Y61_RS06695	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H1Y61_RS06720	COG1982	Orn Lys Arg decarboxylase major
H1Y61_RS06735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1Y61_RS06750	COG1733	regulation of RNA biosynthetic process
H1Y61_RS06765	COG0513	Belongs to the DEAD box helicase family
H1Y61_RS06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS06780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1Y61_RS06785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS06800	COG3706	GGDEF domain
H1Y61_RS06815	COG1064	alcohol dehydrogenase
H1Y61_RS06820	COG3648	Uricase
H1Y61_RS06820	COG3195	allantoin biosynthetic process
H1Y61_RS06830	COG0174	glutamine synthetase
H1Y61_RS06835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Y61_RS06840	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1Y61_RS06845	COG2351	hydroxyisourate hydrolase activity
H1Y61_RS06880	COG0137	argininosuccinate synthase activity
H1Y61_RS06885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS06895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS06900	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS06910	COG0583	DNA-binding transcription factor activity
H1Y61_RS06915	COG0457	Tetratricopeptide repeat
H1Y61_RS06925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Y61_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS06940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1Y61_RS06945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS06950	COG0024	Methionine aminopeptidase
H1Y61_RS06965	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1Y61_RS06985	COG1160	GTP binding
H1Y61_RS06995	COG0366	Alpha amylase catalytic
H1Y61_RS07000	COG4115	mRNA cleavage
H1Y61_RS07010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1Y61_RS07060	COG4175	Glycine betaine
H1Y61_RS07075	COG1435	thymidine kinase activity
H1Y61_RS07090	COG2197	response regulator
H1Y61_RS07100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H1Y61_RS07115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1Y61_RS07135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H1Y61_RS07140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H1Y61_RS07150	COG0512	Glutamine amidotransferase of anthranilate synthase
H1Y61_RS07150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1Y61_RS07175	COG3501	Rhs element vgr protein
H1Y61_RS07205	COG4115	mRNA cleavage
H1Y61_RS07215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1Y61_RS07220	COG3135	benzoate transporter
H1Y61_RS07235	COG0740	serine-type endopeptidase activity
H1Y61_RS07250	COG0435	Glutathione S-transferase
H1Y61_RS07270	COG0454	-acetyltransferase
H1Y61_RS07290	COG0714	Associated with various cellular activities
H1Y61_RS07305	COG0617	tRNA 3'-terminal CCA addition
H1Y61_RS07320	COG0408	coproporphyrinogen oxidase activity
H1Y61_RS07330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS07340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1Y61_RS07345	COG1132	(ABC) transporter
H1Y61_RS07355	COG1132	(ABC) transporter
H1Y61_RS07360	COG3811	Belongs to the UPF0386 family
H1Y61_RS07390	COG2857	Cytochrome c1
H1Y61_RS07390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H1Y61_RS07395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H1Y61_RS07410	COG0386	Belongs to the glutathione peroxidase family
H1Y61_RS07430	COG0012	GTP binding
H1Y61_RS07435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1Y61_RS07450	COG0193	aminoacyl-tRNA hydrolase activity
H1Y61_RS07465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H1Y61_RS07475	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS07490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1Y61_RS07505	COG0006	proline dipeptidase activity
H1Y61_RS07520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H1Y61_RS07540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Y61_RS07545	COG2205	protein histidine kinase activity
H1Y61_RS07550	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS07555	COG1846	Transcriptional regulator
H1Y61_RS07565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Y61_RS07570	COG1278	Cold shock
H1Y61_RS07585	COG0436	Aminotransferase
H1Y61_RS07595	COG0387	Pfam Sodium calcium exchanger
H1Y61_RS07615	COG1902	pentaerythritol trinitrate reductase activity
H1Y61_RS07620	COG0640	Transcriptional regulator
H1Y61_RS07625	COG0583	DNA-binding transcription factor activity
H1Y61_RS07630	COG0492	ferredoxin-NADP+ reductase activity
H1Y61_RS07635	COG1522	sequence-specific DNA binding
H1Y61_RS07670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1Y61_RS07680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H1Y61_RS07700	COG2321	neutral zinc metallopeptidase
H1Y61_RS07705	COG0667	Aldo Keto reductase
H1Y61_RS07710	COG0583	DNA-binding transcription factor activity
H1Y61_RS07715	COG0534	Mate efflux family protein
H1Y61_RS07720	COG0505	Belongs to the CarA family
H1Y61_RS07745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1Y61_RS07760	COG1473	amidohydrolase
H1Y61_RS07775	COG0583	DNA-binding transcription factor activity
H1Y61_RS07785	COG2203	Gaf domain
H1Y61_RS07785	COG5001	Diguanylate cyclase
H1Y61_RS07785	COG4251	negative regulation of phosphorylation
H1Y61_RS07785	COG3706	GGDEF domain
H1Y61_RS07790	COG0432	Pfam Uncharacterised protein family UPF0047
H1Y61_RS07825	COG1278	Cold shock
H1Y61_RS07890	COG1475	DNA binding
H1Y61_RS07985	COG4373	Mu-like prophage FluMu protein gp28
H1Y61_RS08120	COG2968	Membrane
H1Y61_RS08130	COG0697	spore germination
H1Y61_RS08135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1Y61_RS08180	COG1396	sequence-specific DNA binding
H1Y61_RS08185	COG2197	response regulator
H1Y61_RS08190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Y61_RS08205	COG3842	ATPase activity
H1Y61_RS08215	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS08240	COG1376	ErfK ybiS ycfS ynhG family protein
H1Y61_RS08255	COG0251	oxidation-reduction process
H1Y61_RS08260	COG0028	Belongs to the TPP enzyme family
H1Y61_RS08265	COG0697	spore germination
H1Y61_RS08270	COG2267	carboxylic ester hydrolase activity
H1Y61_RS08285	COG0840	transmembrane signaling receptor activity
H1Y61_RS08290	COG0840	transmembrane signaling receptor activity
H1Y61_RS08295	COG2226	methyltransferase
H1Y61_RS08360	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1Y61_RS08380	COG2001	Belongs to the MraZ family
H1Y61_RS08385	COG0275	rRNA processing
H1Y61_RS08400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1Y61_RS08410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1Y61_RS08415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H1Y61_RS08425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1Y61_RS08430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1Y61_RS08435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H1Y61_RS08440	COG0477	Major facilitator Superfamily
H1Y61_RS08445	COG1181	Belongs to the D-alanine--D-alanine ligase family
H1Y61_RS08450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1Y61_RS08455	COG0849	cell division
H1Y61_RS08460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1Y61_RS08470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1Y61_RS08480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1Y61_RS08490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1Y61_RS08525	COG0456	acetyltransferase
H1Y61_RS08530	COG0840	transmembrane signaling receptor activity
H1Y61_RS08540	COG2176	DNA-directed DNA polymerase activity
H1Y61_RS08555	COG0835	chemotaxis
H1Y61_RS08560	COG0840	transmembrane signaling receptor activity
H1Y61_RS08565	COG1999	signal sequence binding
H1Y61_RS08570	COG2264	protein methyltransferase activity
H1Y61_RS08605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1Y61_RS08615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H1Y61_RS08620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H1Y61_RS08625	COG1335	isochorismatase
H1Y61_RS08630	COG4993	Dehydrogenase
H1Y61_RS08650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1Y61_RS08655	COG0573	inorganic phosphate transmembrane transporter activity
H1Y61_RS08660	COG0581	inorganic phosphate transmembrane transporter activity
H1Y61_RS08665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1Y61_RS08670	COG0277	FAD linked oxidase domain protein
H1Y61_RS08705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H1Y61_RS08710	COG2259	Doxx family
H1Y61_RS08725	COG0330	HflC and HflK could
H1Y61_RS08740	COG0560	Phosphoserine phosphatase
H1Y61_RS08740	COG3830	Belongs to the UPF0237 family
H1Y61_RS08745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H1Y61_RS08765	COG0028	Belongs to the TPP enzyme family
H1Y61_RS08780	COG0656	L-ascorbic acid biosynthetic process
H1Y61_RS08790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Y61_RS08795	COG0789	Transcriptional regulator
H1Y61_RS08800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1Y61_RS08810	COG1733	regulation of RNA biosynthetic process
H1Y61_RS08820	COG2814	Major facilitator Superfamily
H1Y61_RS08825	COG1309	transcriptional regulator
H1Y61_RS08830	COG1794	racemase activity, acting on amino acids and derivatives
H1Y61_RS08835	COG1522	sequence-specific DNA binding
H1Y61_RS08850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1Y61_RS08860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H1Y61_RS08885	COG0384	phenazine biosynthesis protein PhzF
H1Y61_RS09005	COG3750	Belongs to the UPF0335 family
H1Y61_RS09185	COG0076	glutamate decarboxylase activity
H1Y61_RS09195	COG0405	Gamma-glutamyltransferase
H1Y61_RS09225	COG0431	NADPH-dependent FMN reductase
H1Y61_RS09230	COG0318	PFAM AMP-dependent synthetase and ligase
H1Y61_RS09245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1Y61_RS09250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Y61_RS09255	COG4558	Periplasmic binding protein
H1Y61_RS09270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H1Y61_RS09270	COG3264	Mechanosensitive ion channel
H1Y61_RS09275	COG2226	methyltransferase
H1Y61_RS09290	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS09300	COG1131	(ABC) transporter
H1Y61_RS09305	COG0842	Transport permease protein
H1Y61_RS09365	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS09375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS09380	COG0584	glycerophosphoryl diester phosphodiesterase
H1Y61_RS09400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Y61_RS09415	COG0525	valine-tRNA ligase activity
H1Y61_RS09435	COG0316	Belongs to the HesB IscA family
H1Y61_RS09440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H1Y61_RS09445	COG0018	arginyl-trna synthetase
H1Y61_RS09455	COG1472	Belongs to the glycosyl hydrolase 3 family
H1Y61_RS09460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1Y61_RS09465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1Y61_RS09470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1Y61_RS09475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1Y61_RS09480	COG0805	protein transport
H1Y61_RS09485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1Y61_RS09490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1Y61_RS09495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Y61_RS09510	COG1862	Preprotein translocase
H1Y61_RS09535	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H1Y61_RS09590	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H1Y61_RS09615	COG2875	Belongs to the precorrin methyltransferase family
H1Y61_RS09625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H1Y61_RS09630	COG2099	Precorrin-6x reductase
H1Y61_RS09635	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H1Y61_RS09660	COG2239	Acts as a magnesium transporter
H1Y61_RS09685	COG1760	l-serine dehydratase
H1Y61_RS09695	COG0835	chemotaxis
H1Y61_RS09705	COG2972	Histidine kinase
H1Y61_RS09705	COG0840	transmembrane signaling receptor activity
H1Y61_RS09710	COG1058	Belongs to the CinA family
H1Y61_RS09710	COG1546	Belongs to the CinA family
H1Y61_RS09720	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H1Y61_RS09730	COG0840	transmembrane signaling receptor activity
H1Y61_RS09735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1Y61_RS09755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Y61_RS09785	COG0583	DNA-binding transcription factor activity
H1Y61_RS09810	COG3698	Phosphodiester glycosidase
H1Y61_RS09830	COG0517	IMP dehydrogenase activity
H1Y61_RS09830	COG4175	Glycine betaine
H1Y61_RS09835	COG4176	ABC-type proline glycine betaine transport system permease component
H1Y61_RS09845	COG1492	cobalamin metabolic process
H1Y61_RS09850	COG0671	phosphoesterase, PA-phosphatase related
H1Y61_RS09855	COG0303	'Molybdopterin
H1Y61_RS09860	COG0315	cyclic pyranopterin monophosphate synthase activity
H1Y61_RS09865	COG0134	indole-3-glycerol-phosphate synthase activity
H1Y61_RS09870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1Y61_RS09880	COG0372	Belongs to the citrate synthase family
H1Y61_RS09885	COG0658	competence protein
H1Y61_RS09885	COG2333	competence protein COMEC
H1Y61_RS09890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1Y61_RS09895	COG2313	pseudouridylate synthase activity
H1Y61_RS09905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H1Y61_RS09910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1Y61_RS09920	COG1126	abc transporter atp-binding protein
H1Y61_RS09925	COG0765	amino acid transport
H1Y61_RS09930	COG4597	amino acid ABC transporter
H1Y61_RS09935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Y61_RS09940	COG0626	cystathionine gamma-synthase activity
H1Y61_RS09955	COG2267	carboxylic ester hydrolase activity
H1Y61_RS09980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1Y61_RS10000	COG0537	adenosine 5'-monophosphoramidase activity
H1Y61_RS10025	COG0052	Belongs to the universal ribosomal protein uS2 family
H1Y61_RS10030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H1Y61_RS10035	COG0528	UMP kinase activity
H1Y61_RS10040	COG0233	cytoplasmic translational termination
H1Y61_RS10045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1Y61_RS10055	COG0750	zinc metalloprotease
H1Y61_RS10060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1Y61_RS10065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Y61_RS10070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Y61_RS10075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Y61_RS10085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Y61_RS10090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H1Y61_RS10100	COG1671	Belongs to the UPF0178 family
H1Y61_RS10105	COG2153	protein acetylation
H1Y61_RS10110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1Y61_RS10130	COG4770	biotin carboxylase activity
H1Y61_RS10140	COG3665	Urea carboxylase-associated protein
H1Y61_RS10145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1Y61_RS10160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1Y61_RS10165	COG0463	Glycosyl transferase, family 2
H1Y61_RS10175	COG0737	Belongs to the 5'-nucleotidase family
H1Y61_RS10185	COG0252	asparaginase activity
H1Y61_RS10200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1Y61_RS10205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1Y61_RS10235	COG0544	peptidyl-prolyl cis-trans isomerase activity
H1Y61_RS10240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1Y61_RS10250	COG0436	Aminotransferase
H1Y61_RS10265	COG3768	UPF0283 membrane protein
H1Y61_RS10270	COG3106	COG3106 Predicted ATPase
H1Y61_RS10275	COG2062	phosphohistidine phosphatase, SixA
H1Y61_RS10305	COG2080	2 iron, 2 sulfur cluster binding
H1Y61_RS10310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1Y61_RS10315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Y61_RS10320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H1Y61_RS10340	COG0343	queuine tRNA-ribosyltransferase activity
H1Y61_RS10345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H1Y61_RS10360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H1Y61_RS10375	COG2151	metal-sulfur cluster biosynthetic enzyme
H1Y61_RS10380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1Y61_RS10385	COG0346	lactoylglutathione lyase activity
H1Y61_RS10395	COG0396	ATPase activity
H1Y61_RS10405	COG0719	Fe-S assembly protein
H1Y61_RS10410	COG1104	cysteine desulfurase activity
H1Y61_RS10415	COG2945	thiolester hydrolase activity
H1Y61_RS10420	COG1280	lysine exporter protein (LysE YggA)
H1Y61_RS10425	COG0513	Belongs to the DEAD box helicase family
H1Y61_RS10450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Y61_RS10475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1Y61_RS10505	COG0129	dihydroxy-acid dehydratase activity
H1Y61_RS10510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H1Y61_RS10515	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H1Y61_RS10530	COG3507	Belongs to the glycosyl hydrolase 43 family
H1Y61_RS10535	COG0667	Aldo Keto reductase
H1Y61_RS10555	COG3842	ATPase activity
H1Y61_RS10560	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS10565	COG1175	transmembrane transport
H1Y61_RS10570	COG1653	transport
H1Y61_RS10585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H1Y61_RS10610	COG2217	Heavy metal translocating P-type atpase
H1Y61_RS10615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1Y61_RS10620	COG2095	MarC family integral membrane protein
H1Y61_RS10630	COG0629	single-stranded DNA binding
H1Y61_RS10635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1Y61_RS10650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1Y61_RS10650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1Y61_RS10655	COG0347	Belongs to the P(II) protein family
H1Y61_RS10660	COG0174	glutamine synthetase
H1Y61_RS10685	COG0697	spore germination
H1Y61_RS10695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1Y61_RS10705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1Y61_RS10735	COG1278	Cold shock
H1Y61_RS10740	COG0346	lactoylglutathione lyase activity
H1Y61_RS10765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1Y61_RS10775	COG0436	Aminotransferase
H1Y61_RS10785	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1Y61_RS10790	COG1489	DNA binding
H1Y61_RS10795	COG2855	membrane
H1Y61_RS10800	COG0583	DNA-binding transcription factor activity
H1Y61_RS10805	COG0024	Methionine aminopeptidase
H1Y61_RS10810	COG2003	Belongs to the UPF0758 family
H1Y61_RS10825	COG0477	Major facilitator Superfamily
H1Y61_RS10840	COG0546	phosphoglycolate phosphatase activity
H1Y61_RS10845	COG0564	pseudouridine synthase activity
H1Y61_RS10850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H1Y61_RS10870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Y61_RS10875	COG0509	glycine decarboxylation via glycine cleavage system
H1Y61_RS10880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1Y61_RS10880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1Y61_RS10915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1Y61_RS10925	COG0633	Ferredoxin
H1Y61_RS10950	COG0504	CTP synthase activity
H1Y61_RS10960	COG0149	triose-phosphate isomerase activity
H1Y61_RS10975	COG0187	DNA topoisomerase II activity
H1Y61_RS11020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1Y61_RS11025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1Y61_RS11040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H1Y61_RS11045	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H1Y61_RS11055	COG0302	gtp cyclohydrolase
H1Y61_RS11060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1Y61_RS11065	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1Y61_RS11100	COG1686	Belongs to the peptidase S11 family
H1Y61_RS11120	COG0735	belongs to the Fur family
H1Y61_RS11125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1Y61_RS11130	COG1121	(ABC) transporter
H1Y61_RS11140	COG0523	cobalamin synthesis protein
H1Y61_RS11155	COG3842	ATPase activity
H1Y61_RS11160	COG4149	molybdate abc transporter
H1Y61_RS11165	COG1177	transmembrane transport
H1Y61_RS11185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1Y61_RS11190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1Y61_RS11210	COG1129	ABC transporter
H1Y61_RS11215	COG1183	phosphatidylcholine synthase activity
H1Y61_RS11220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Y61_RS11225	COG0785	Cytochrome C biogenesis protein
H1Y61_RS11240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1Y61_RS11240	COG0321	lipoyl(octanoyl) transferase activity
H1Y61_RS11245	COG0084	hydrolase, TatD family'
H1Y61_RS11250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Y61_RS11255	COG0730	response to heat
H1Y61_RS11265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H1Y61_RS11270	COG1686	Belongs to the peptidase S11 family
H1Y61_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS11305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1Y61_RS11305	COG1648	precorrin-2 dehydrogenase activity
H1Y61_RS11315	COG3956	TIGRFAM MazG family protein
H1Y61_RS11325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1Y61_RS11330	COG1923	regulation of RNA biosynthetic process
H1Y61_RS11335	COG2204	response regulator
H1Y61_RS11340	COG5000	phosphorelay sensor kinase activity
H1Y61_RS11345	COG2204	response regulator
H1Y61_RS11350	COG3852	Histidine kinase
H1Y61_RS11360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H1Y61_RS11360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H1Y61_RS11365	COG1058	Belongs to the CinA family
H1Y61_RS11365	COG1546	Belongs to the CinA family
H1Y61_RS11375	COG2867	negative regulation of translational initiation
H1Y61_RS11380	COG0477	Major facilitator Superfamily
H1Y61_RS11400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1Y61_RS11410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1Y61_RS11430	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Y61_RS11435	COG0022	dehydrogenase e1 component
H1Y61_RS11435	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Y61_RS11440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1Y61_RS11450	COG0148	phosphopyruvate hydratase activity
H1Y61_RS11455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H1Y61_RS11465	COG3161	chorismate lyase activity
H1Y61_RS11485	COG0556	nucleotide-excision repair
H1Y61_RS11490	COG3706	GGDEF domain
H1Y61_RS11490	COG4251	negative regulation of phosphorylation
H1Y61_RS11490	COG2203	Gaf domain
H1Y61_RS11490	COG5001	Diguanylate cyclase
H1Y61_RS11525	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H1Y61_RS11540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H1Y61_RS11545	COG0546	phosphoglycolate phosphatase activity
H1Y61_RS11550	COG2989	Protein conserved in bacteria
H1Y61_RS11555	COG0114	fumarate hydratase activity
H1Y61_RS11570	COG3706	GGDEF domain
H1Y61_RS11580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1Y61_RS11590	COG0746	molybdenum cofactor guanylyltransferase activity
H1Y61_RS11595	COG1763	Mo-molybdopterin cofactor biosynthetic process
H1Y61_RS11620	COG5425	PFAM Usg family protein
H1Y61_RS11635	COG2084	Dehydrogenase
H1Y61_RS11640	COG1522	sequence-specific DNA binding
H1Y61_RS11645	COG1573	uracil-dna glycosylase
H1Y61_RS11655	COG2202	Pas domain
H1Y61_RS11655	COG2205	protein histidine kinase activity
H1Y61_RS11675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1Y61_RS11680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1Y61_RS11695	COG0778	Nitroreductase
H1Y61_RS11700	COG0823	Involved in the tonB-independent uptake of proteins
H1Y61_RS11725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Y61_RS11730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Y61_RS11735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Y61_RS11740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS11745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1Y61_RS11755	COG0242	peptide deformylase activity
H1Y61_RS11785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1Y61_RS11790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H1Y61_RS11805	COG2963	transposase activity
H1Y61_RS11815	COG4372	Transposase
H1Y61_RS11835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H1Y61_RS11835	COG0463	Glycosyl transferase, family 2
H1Y61_RS11955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1Y61_RS12035	COG0250	Participates in transcription elongation, termination and antitermination
H1Y61_RS12105	COG0321	lipoyl(octanoyl) transferase activity
H1Y61_RS12115	COG0484	heat shock protein binding
H1Y61_RS12120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1Y61_RS12135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1Y61_RS12140	COG2814	Major facilitator Superfamily
H1Y61_RS12145	COG0483	inositol monophosphate 1-phosphatase activity
H1Y61_RS12150	COG0483	inositol monophosphate 1-phosphatase activity
H1Y61_RS12155	COG0037	tRNA processing
H1Y61_RS12165	COG2066	Belongs to the glutaminase family
H1Y61_RS12170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H1Y61_RS12175	COG0861	Integral membrane protein TerC family
H1Y61_RS12190	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1Y61_RS12195	COG0657	acetylesterase activity
H1Y61_RS12195	COG2755	lipolytic protein G-D-S-L family
H1Y61_RS12205	COG1253	flavin adenine dinucleotide binding
H1Y61_RS12215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1Y61_RS12220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H1Y61_RS12225	COG0538	isocitrate dehydrogenase activity
H1Y61_RS12235	COG3706	GGDEF domain
H1Y61_RS12250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1Y61_RS12255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1Y61_RS12260	COG0047	phosphoribosylformylglycinamidine synthase activity
H1Y61_RS12280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1Y61_RS12285	COG3218	ABC-type transport auxiliary lipoprotein component
H1Y61_RS12285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1Y61_RS12295	COG1127	ABC transporter
H1Y61_RS12300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1Y61_RS12310	COG0281	malic enzyme
H1Y61_RS12310	COG0280	phosphate acetyltransferase
H1Y61_RS12335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1Y61_RS12340	COG2833	Protein of unknown function (DUF455)
H1Y61_RS12345	COG0739	heme binding
H1Y61_RS12355	COG0415	Belongs to the DNA photolyase family
H1Y61_RS12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1Y61_RS12365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1Y61_RS12370	COG2897	thiosulfate sulfurtransferase activity
H1Y61_RS12385	COG0203	ribosomal protein L17
H1Y61_RS12390	COG0202	RNA polymerase activity
H1Y61_RS12395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H1Y61_RS12400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H1Y61_RS12405	COG0563	adenylate kinase activity
H1Y61_RS12410	COG0201	protein transport
H1Y61_RS12415	COG0200	Binds to the 23S rRNA
H1Y61_RS12420	COG1841	ribosomal large subunit assembly
H1Y61_RS12425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H1Y61_RS12430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H1Y61_RS12435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H1Y61_RS12440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H1Y61_RS12445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H1Y61_RS12450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H1Y61_RS12455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H1Y61_RS12460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H1Y61_RS12465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H1Y61_RS12470	COG0255	Belongs to the universal ribosomal protein uL29 family
H1Y61_RS12475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H1Y61_RS12480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H1Y61_RS12485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H1Y61_RS12490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H1Y61_RS12495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H1Y61_RS12500	COG0089	rRNA binding
H1Y61_RS12505	COG0088	Forms part of the polypeptide exit tunnel
H1Y61_RS12510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H1Y61_RS12515	COG0051	transcription antitermination factor activity, RNA binding
H1Y61_RS12520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1Y61_RS12525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1Y61_RS12530	COG0049	tRNA binding
H1Y61_RS12535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H1Y61_RS12550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H1Y61_RS12555	COG0085	RNA polymerase activity
H1Y61_RS12560	COG0222	ribosome binding
H1Y61_RS12565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H1Y61_RS12570	COG0081	regulation of translation
H1Y61_RS12575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H1Y61_RS12585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H1Y61_RS12610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1Y61_RS12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Y61_RS12645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1Y61_RS12655	COG0284	orotidine-5'-phosphate decarboxylase activity
H1Y61_RS12665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1Y61_RS12670	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1Y61_RS12675	COG1530	ribonuclease E activity
H1Y61_RS12675	COG1530	ribonuclease E activity
H1Y61_RS12685	COG0436	Aminotransferase
H1Y61_RS12690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1Y61_RS12695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1Y61_RS12700	COG0511	ligase activity, forming carbon-carbon bonds
H1Y61_RS12710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1Y61_RS12715	COG4765	Protein conserved in bacteria
H1Y61_RS12735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1Y61_RS12740	COG0463	Glycosyl transferase, family 2
H1Y61_RS12745	COG3952	Lipid A Biosynthesis
H1Y61_RS12745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Y61_RS12750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H1Y61_RS12765	COG0154	amidase activity
H1Y61_RS12770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1Y61_RS12775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1Y61_RS12780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1Y61_RS12805	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS12810	COG0540	Belongs to the ATCase OTCase family
H1Y61_RS12820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H1Y61_RS12825	COG0758	DNA mediated transformation
H1Y61_RS12835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1Y61_RS12840	COG0557	exoribonuclease II activity
H1Y61_RS12850	COG0477	Major facilitator Superfamily
H1Y61_RS12855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H1Y61_RS12865	COG0784	Response regulator, receiver
H1Y61_RS12880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1Y61_RS12895	COG1136	(ABC) transporter
H1Y61_RS12905	COG0442	prolyl-tRNA aminoacylation
H1Y61_RS12920	COG0346	lactoylglutathione lyase activity
H1Y61_RS12935	COG1007	ATP synthesis coupled electron transport
H1Y61_RS12950	COG0713	ATP synthesis coupled electron transport
H1Y61_RS12960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Y61_RS12965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H1Y61_RS12975	COG0052	Belongs to the universal ribosomal protein uS2 family
H1Y61_RS12980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1Y61_RS12985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H1Y61_RS12995	COG0649	NAD binding
H1Y61_RS13000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Y61_RS13005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Y61_RS13010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Y61_RS13030	COG1024	Enoyl-CoA hydratase
H1Y61_RS13060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1Y61_RS13065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H1Y61_RS13070	COG0740	serine-type endopeptidase activity
H1Y61_RS13080	COG2124	cytochrome p450
H1Y61_RS13090	COG1408	metallophosphoesterase
H1Y61_RS13100	COG1832	CoA-binding protein
H1Y61_RS13110	COG1832	CoA-binding protein
H1Y61_RS13115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H1Y61_RS13120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1Y61_RS13125	COG2329	Antibiotic biosynthesis monooxygenase
H1Y61_RS13140	COG0010	Belongs to the arginase family
H1Y61_RS13145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H1Y61_RS13155	COG3384	dioxygenase
H1Y61_RS13160	COG1612	heme a metabolic process
H1Y61_RS13240	COG0776	regulation of translation
H1Y61_RS13245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1Y61_RS13250	COG0416	fatty acid biosynthetic process
H1Y61_RS13270	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H1Y61_RS13275	COG2814	Major facilitator Superfamily
H1Y61_RS13280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Y61_RS13285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H1Y61_RS13305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Y61_RS13305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Y61_RS13310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H1Y61_RS13315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H1Y61_RS13335	COG0113	porphobilinogen synthase activity
H1Y61_RS13345	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H1Y61_RS13350	COG2199	diguanylate cyclase activity
H1Y61_RS13350	COG2200	EAL domain
H1Y61_RS13350	COG2203	Gaf domain
H1Y61_RS13360	COG5001	Diguanylate cyclase
H1Y61_RS13360	COG3300	MHYT domain
H1Y61_RS13365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1Y61_RS13380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H1Y61_RS13395	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H1Y61_RS13415	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Y61_RS13420	COG1321	iron dependent repressor
H1Y61_RS13425	COG0248	Ppx GppA phosphatase
H1Y61_RS13430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H1Y61_RS13440	COG0628	permease
H1Y61_RS13445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H1Y61_RS13450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1Y61_RS13455	COG0730	response to heat
H1Y61_RS13460	COG2391	methyltransferase activity
H1Y61_RS13470	COG0640	Transcriptional regulator
H1Y61_RS13475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Y61_RS13475	COG3453	Protein conserved in bacteria
H1Y61_RS13485	COG0243	molybdopterin cofactor binding
H1Y61_RS13490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1Y61_RS13495	COG0625	glutathione transferase activity
H1Y61_RS13505	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS13510	COG0322	excinuclease ABC activity
H1Y61_RS13515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1Y61_RS13525	COG0314	molybdopterin synthase activity
H1Y61_RS13530	COG0105	UTP biosynthetic process
H1Y61_RS13560	COG0488	(ABC) transporter
H1Y61_RS13565	COG1505	serine-type exopeptidase activity
H1Y61_RS13580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1Y61_RS13585	COG0671	phosphoesterase, PA-phosphatase related
H1Y61_RS13600	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H1Y61_RS13610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1Y61_RS13615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1Y61_RS13620	COG0500	methyltransferase
H1Y61_RS13625	COG0194	GDP metabolic process
H1Y61_RS13630	COG1561	YicC-like family, N-terminal region
H1Y61_RS13635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1Y61_RS13640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Y61_RS13645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS13655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1Y61_RS13660	COG0667	Aldo Keto reductase
H1Y61_RS13680	COG0360	Binds together with S18 to 16S ribosomal RNA
H1Y61_RS13685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H1Y61_RS13695	COG0359	binds to the 23S rRNA
H1Y61_RS13700	COG0305	Participates in initiation and elongation during chromosome replication
H1Y61_RS13710	COG0765	amino acid transport
H1Y61_RS13715	COG0765	amino acid transport
H1Y61_RS13720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Y61_RS13735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1Y61_RS13740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H1Y61_RS13745	COG1286	toxin biosynthetic process
H1Y61_RS13750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1Y61_RS13755	COG4221	oxidoreductase activity
H1Y61_RS13770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1Y61_RS13775	COG1091	dTDP-4-dehydrorhamnose reductase activity
H1Y61_RS13780	COG1088	dTDP-glucose 4,6-dehydratase activity
H1Y61_RS13785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H1Y61_RS13790	COG5434	Belongs to the glycosyl hydrolase 28 family
H1Y61_RS13795	COG0215	cysteine-tRNA ligase activity
H1Y61_RS13835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1Y61_RS13840	COG2962	Rard protein
H1Y61_RS13850	COG1652	LysM domain
H1Y61_RS13850	COG2823	Periplasmic or secreted lipoprotein
H1Y61_RS13855	COG5265	(ABC) transporter
H1Y61_RS13860	COG0688	phosphatidylethanolamine metabolic process
H1Y61_RS13865	COG1183	phosphatidylcholine synthase activity
H1Y61_RS13880	COG1051	belongs to the nudix hydrolase family
H1Y61_RS13905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H1Y61_RS13920	COG1418	mRNA catabolic process
H1Y61_RS13935	COG1381	Involved in DNA repair and RecF pathway recombination
H1Y61_RS13940	COG3180	Ammonia monooxygenase
H1Y61_RS13945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1Y61_RS13950	COG0571	ribonuclease III activity
H1Y61_RS13955	COG0681	Belongs to the peptidase S26 family
H1Y61_RS13970	COG1758	RNA polymerase activity
H1Y61_RS13980	COG0840	transmembrane signaling receptor activity
H1Y61_RS13985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1Y61_RS13985	COG2169	Transcriptional regulator
H1Y61_RS13995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H1Y61_RS14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS14005	COG0741	lytic transglycosylase activity
H1Y61_RS14050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Y61_RS14065	COG0625	glutathione transferase activity
H1Y61_RS14075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1Y61_RS14085	COG0463	Glycosyl transferase, family 2
H1Y61_RS14090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H1Y61_RS14095	COG1695	Transcriptional regulator
H1Y61_RS14110	COG0174	glutamine synthetase
H1Y61_RS14115	COG4166	transmembrane transport
H1Y61_RS14120	COG0601	transmembrane transport
H1Y61_RS14125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS14130	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS14140	COG2814	Major facilitator Superfamily
H1Y61_RS14145	COG2239	Acts as a magnesium transporter
H1Y61_RS14160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Y61_RS14165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS14180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS14195	COG0443	Heat shock 70 kDa protein
H1Y61_RS14230	COG0840	transmembrane signaling receptor activity
H1Y61_RS14230	COG3290	protein histidine kinase activity
H1Y61_RS14235	COG0308	aminopeptidase N
H1Y61_RS14240	COG2205	protein histidine kinase activity
H1Y61_RS14240	COG2202	Pas domain
H1Y61_RS14245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1Y61_RS14250	COG2205	protein histidine kinase activity
H1Y61_RS14255	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS14260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1Y61_RS14270	COG3088	subunit of a heme lyase
H1Y61_RS14275	COG1138	Cytochrome C-type biogenesis protein
H1Y61_RS14280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H1Y61_RS14285	COG4235	cytochrome complex assembly
H1Y61_RS14290	COG4520	surface antigen
H1Y61_RS14295	COG2205	protein histidine kinase activity
H1Y61_RS14300	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS14395	COG4695	Portal protein
H1Y61_RS14420	COG0789	Transcriptional regulator
H1Y61_RS14440	COG2983	Belongs to the UPF0260 family
H1Y61_RS14445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1Y61_RS14505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS14520	COG2205	protein histidine kinase activity
H1Y61_RS14530	COG2166	iron-sulfur cluster assembly
H1Y61_RS14550	COG0577	efflux transmembrane transporter activity
H1Y61_RS14550	COG1136	(ABC) transporter
H1Y61_RS14555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS14575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1Y61_RS14585	COG2111	Na H antiporter
H1Y61_RS14590	COG1006	Multisubunit Na H antiporter MnhC subunit
H1Y61_RS14600	COG1863	multisubunit Na H antiporter MnhE subunit
H1Y61_RS14605	COG2212	antiporter activity
H1Y61_RS14610	COG1320	monovalent cation:proton antiporter activity
H1Y61_RS14615	COG4957	zinc ion binding
H1Y61_RS14635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Y61_RS14640	COG1272	protein, Hemolysin III
H1Y61_RS14645	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H1Y61_RS14660	COG2514	catechol 2,3-dioxygenase activity
H1Y61_RS14710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS14715	COG5001	Diguanylate cyclase
H1Y61_RS14715	COG3447	MASE1 domain protein
H1Y61_RS14715	COG5002	protein histidine kinase activity
H1Y61_RS14725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1Y61_RS14730	COG1733	regulation of RNA biosynthetic process
H1Y61_RS14735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1Y61_RS14740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Y61_RS14760	COG2010	Cytochrome c
H1Y61_RS14780	COG2226	methyltransferase
H1Y61_RS14795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Y61_RS14800	COG1120	ATPase activity
H1Y61_RS14810	COG3077	Addiction module antitoxin, RelB DinJ family
H1Y61_RS14825	COG1940	carbohydrate kinase activity
H1Y61_RS14825	COG1846	Transcriptional regulator
H1Y61_RS14830	COG4213	ABC transporter substrate-binding protein
H1Y61_RS14840	COG4214	carbohydrate transport
H1Y61_RS14850	COG1968	undecaprenyl-diphosphatase activity
H1Y61_RS14855	COG0840	transmembrane signaling receptor activity
H1Y61_RS14860	COG1473	amidohydrolase
H1Y61_RS14865	COG0433	COG0433 Predicted ATPase
H1Y61_RS14875	COG0840	transmembrane signaling receptor activity
H1Y61_RS14880	COG0840	transmembrane signaling receptor activity
H1Y61_RS14885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1Y61_RS14890	COG3265	gluconokinase activity
H1Y61_RS14895	COG0784	Response regulator, receiver
H1Y61_RS14895	COG4191	Histidine kinase
H1Y61_RS14920	COG1764	response to oxidative stress
H1Y61_RS14925	COG1846	Transcriptional regulator
H1Y61_RS14930	COG1376	ErfK ybiS ycfS ynhG family protein
H1Y61_RS14935	COG1388	LysM domain
H1Y61_RS14935	COG1376	ErfK ybiS ycfS ynhG family protein
H1Y61_RS14955	COG0778	Nitroreductase
H1Y61_RS14965	COG0477	Major facilitator Superfamily
H1Y61_RS15010	COG1349	DNA-binding transcription factor activity
H1Y61_RS15035	COG0840	transmembrane signaling receptor activity
H1Y61_RS15045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H1Y61_RS15050	COG1309	transcriptional regulator
H1Y61_RS15055	COG3119	arylsulfatase activity
H1Y61_RS15060	COG0625	glutathione transferase activity
H1Y61_RS15065	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS15075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1Y61_RS15100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS15105	COG0038	chloride channel
H1Y61_RS15230	COG0693	protein deglycase activity
H1Y61_RS15240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Y61_RS15250	COG1609	Transcriptional regulator
H1Y61_RS15260	COG2895	sulfate adenylyltransferase (ATP) activity
H1Y61_RS15265	COG0175	sulfate reduction
H1Y61_RS15270	COG0175	sulfate reduction
H1Y61_RS15275	COG0840	transmembrane signaling receptor activity
H1Y61_RS15295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS15330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1Y61_RS15330	COG0574	Belongs to the PEP-utilizing enzyme family
H1Y61_RS15345	COG2814	Major facilitator Superfamily
H1Y61_RS15355	COG1196	nuclear chromosome segregation
H1Y61_RS15370	COG1194	a g-specific adenine glycosylase
H1Y61_RS15400	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H1Y61_RS15410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Y61_RS15430	COG0612	Peptidase, M16
H1Y61_RS15435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Y61_RS15440	COG5001	Diguanylate cyclase
H1Y61_RS15445	COG0640	Transcriptional regulator
H1Y61_RS15455	COG1678	Uncharacterized ACR, COG1678
H1Y61_RS15465	COG0678	peroxiredoxin activity
H1Y61_RS15465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1Y61_RS15480	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1Y61_RS15490	COG0328	RNA-DNA hybrid ribonuclease activity
H1Y61_RS15495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1Y61_RS15505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H1Y61_RS15515	COG3346	SURF1 family
H1Y61_RS15530	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H1Y61_RS15540	COG0109	protoheme IX farnesyltransferase activity
H1Y61_RS15545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1Y61_RS15560	COG0312	modulator of DNA gyrase
H1Y61_RS15570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Y61_RS15585	COG1686	Belongs to the peptidase S11 family
H1Y61_RS15590	COG0789	Transcriptional regulator
H1Y61_RS15595	COG2814	Major facilitator Superfamily
H1Y61_RS15605	COG0259	pyridoxamine-phosphate oxidase activity
H1Y61_RS15615	COG0484	heat shock protein binding
H1Y61_RS15620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1Y61_RS15635	COG5001	Diguanylate cyclase
H1Y61_RS15635	COG3300	MHYT domain
H1Y61_RS15640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H1Y61_RS15645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1Y61_RS15645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1Y61_RS15670	COG3214	Protein conserved in bacteria
H1Y61_RS15680	COG1122	ATPase activity
H1Y61_RS15685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H1Y61_RS15690	COG1268	BioY protein
H1Y61_RS15705	COG0123	including yeast histone deacetylase and acetoin utilization protein
H1Y61_RS15710	COG1722	exodeoxyribonuclease VII activity
H1Y61_RS15715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H1Y61_RS15720	COG0840	transmembrane signaling receptor activity
H1Y61_RS15725	COG0840	transmembrane signaling receptor activity
H1Y61_RS15735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H1Y61_RS15745	COG1024	Enoyl-CoA hydratase
H1Y61_RS15750	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS15775	COG4638	Rieske (2fe-2S)
H1Y61_RS15780	COG0840	transmembrane signaling receptor activity
H1Y61_RS15790	COG0009	L-threonylcarbamoyladenylate synthase
H1Y61_RS15800	COG3585	molybdate ion transport
H1Y61_RS15800	COG2005	Transcriptional regulator
H1Y61_RS15810	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1Y61_RS15815	COG4149	molybdate abc transporter
H1Y61_RS15820	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1Y61_RS15850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Y61_RS15855	COG2183	response to ionizing radiation
H1Y61_RS15865	COG0151	Belongs to the GarS family
H1Y61_RS15875	COG0840	transmembrane signaling receptor activity
H1Y61_RS15880	COG1683	Conserved Protein
H1Y61_RS15885	COG0751	glycine-tRNA ligase activity
H1Y61_RS15890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1Y61_RS15900	COG0752	glycyl-tRNA synthetase alpha subunit
H1Y61_RS15930	COG0142	geranyltranstransferase activity
H1Y61_RS15940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H1Y61_RS15945	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1Y61_RS15960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1Y61_RS15965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1Y61_RS15970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1Y61_RS15980	COG0356	it plays a direct role in the translocation of protons across the membrane
H1Y61_RS15990	COG3158	transport of potassium into the cell
H1Y61_RS16010	COG2771	luxR family
H1Y61_RS16020	COG3386	PFAM SMP-30 Gluconolaconase
H1Y61_RS16030	COG0477	Major facilitator Superfamily
H1Y61_RS16040	COG0590	tRNA wobble adenosine to inosine editing
H1Y61_RS16045	COG1187	pseudouridine synthase activity
H1Y61_RS16050	COG0742	ribosomal rna small subunit methyltransferase
H1Y61_RS16065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1Y61_RS16065	COG0475	glutathione-regulated potassium exporter activity
H1Y61_RS16070	COG0312	modulator of DNA gyrase
H1Y61_RS16075	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1Y61_RS16085	COG1519	Transferase
H1Y61_RS16095	COG1663	tetraacyldisaccharide 4'-kinase activity
H1Y61_RS16105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1Y61_RS16110	COG5002	protein histidine kinase activity
H1Y61_RS16110	COG2198	Histidine kinase
H1Y61_RS16110	COG0784	Response regulator, receiver
H1Y61_RS16115	COG5001	Diguanylate cyclase
H1Y61_RS16115	COG3300	MHYT domain
H1Y61_RS16125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H1Y61_RS16130	COG0248	Ppx GppA phosphatase
H1Y61_RS16170	COG0579	oxidoreductase
H1Y61_RS16175	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS16190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Y61_RS16195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS16200	COG2134	cdp-diacylglycerol pyrophosphatase
H1Y61_RS16205	COG3265	gluconokinase activity
H1Y61_RS16210	COG1959	2 iron, 2 sulfur cluster binding
H1Y61_RS16260	COG2205	protein histidine kinase activity
H1Y61_RS16270	COG1177	transmembrane transport
H1Y61_RS16275	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Y61_RS16280	COG3842	ATPase activity
H1Y61_RS16295	COG2224	Isocitrate lyase
H1Y61_RS16315	COG0583	DNA-binding transcription factor activity
H1Y61_RS16320	COG0840	transmembrane signaling receptor activity
H1Y61_RS16320	COG2972	Histidine kinase
H1Y61_RS16340	COG2081	HI0933 family
H1Y61_RS16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS16355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H1Y61_RS16360	COG0363	glucosamine-6-phosphate deaminase activity
H1Y61_RS16365	COG0129	dihydroxy-acid dehydratase activity
H1Y61_RS16375	COG3493	citrate carrier protein
H1Y61_RS16390	COG3842	ATPase activity
H1Y61_RS16395	COG0366	Alpha amylase catalytic
H1Y61_RS16400	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS16405	COG1175	transmembrane transport
H1Y61_RS16410	COG1653	transport
H1Y61_RS16415	COG1609	Transcriptional regulator
H1Y61_RS16420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H1Y61_RS16455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1Y61_RS16460	COG4794	Type iii secretion
H1Y61_RS16465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H1Y61_RS16470	COG5443	negative regulation of bacterial-type flagellum assembly
H1Y61_RS16490	COG1749	Flagellar hook protein flgE
H1Y61_RS16515	COG1360	Flagellar Motor Protein
H1Y61_RS16525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS16530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS16535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS16540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS16545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Y61_RS16550	COG1338	Plays a role in the flagellum-specific transport system
H1Y61_RS16560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H1Y61_RS16570	COG1706	bacterial-type flagellum-dependent cell motility
H1Y61_RS16575	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H1Y61_RS16580	COG4786	Flagellar basal body rod
H1Y61_RS16585	COG1677	Flagellar hook-basal body complex protein FliE
H1Y61_RS16590	COG1558	bacterial-type flagellum-dependent cell motility
H1Y61_RS16595	COG1815	bacterial-type flagellum-dependent cell motility
H1Y61_RS16605	COG1157	protein secretion by the type III secretion system
H1Y61_RS16610	COG4786	Flagellar basal body rod
H1Y61_RS16615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H1Y61_RS16620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Y61_RS16625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Y61_RS16630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Y61_RS16635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1Y61_RS16660	COG0488	(ABC) transporter
H1Y61_RS16670	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS16705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1Y61_RS16715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1Y61_RS16720	COG5328	Belongs to the UPF0262 family
H1Y61_RS16730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H1Y61_RS16735	COG0424	maF-like protein
H1Y61_RS16740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1Y61_RS16765	COG1216	Glycosyl transferase, family 2
H1Y61_RS16785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1Y61_RS16790	COG0436	Aminotransferase
H1Y61_RS16795	COG1970	mechanosensitive ion channel activity
H1Y61_RS16800	COG0784	Response regulator, receiver
H1Y61_RS16800	COG2198	Histidine kinase
H1Y61_RS16800	COG2205	protein histidine kinase activity
H1Y61_RS16805	COG1047	Peptidyl-prolyl cis-trans
H1Y61_RS16825	COG1201	RNA secondary structure unwinding
H1Y61_RS16835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H1Y61_RS16840	COG5001	Diguanylate cyclase
H1Y61_RS16840	COG2203	Gaf domain
H1Y61_RS16840	COG3706	GGDEF domain
H1Y61_RS16840	COG4251	negative regulation of phosphorylation
H1Y61_RS16855	COG1136	(ABC) transporter
H1Y61_RS16865	COG1785	Belongs to the alkaline phosphatase family
H1Y61_RS16885	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS16890	COG0183	Belongs to the thiolase family
H1Y61_RS16895	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1Y61_RS16895	COG1024	Enoyl-CoA hydratase
H1Y61_RS16935	COG0167	dihydroorotate dehydrogenase activity
H1Y61_RS16960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Y61_RS16980	COG0587	DNA-directed DNA polymerase activity
H1Y61_RS17005	COG0307	riboflavin synthase, alpha
H1Y61_RS17010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Y61_RS17020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Y61_RS17020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Y61_RS17030	COG3475	LICD family
H1Y61_RS17045	COG3246	L-lysine catabolic process to acetate
H1Y61_RS17050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1Y61_RS17070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H1Y61_RS17080	COG0732	type I restriction modification DNA specificity domain
H1Y61_RS17085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H1Y61_RS17090	COG3501	Rhs element vgr protein
H1Y61_RS17180	COG0717	Belongs to the dCTP deaminase family
H1Y61_RS17190	COG2967	ApaG domain
H1Y61_RS17195	COG0242	peptide deformylase activity
H1Y61_RS17200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1Y61_RS17205	COG0101	tRNA pseudouridine synthase activity
H1Y61_RS17230	COG0318	PFAM AMP-dependent synthetase and ligase
H1Y61_RS17235	COG0166	Belongs to the GPI family
H1Y61_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS17250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1Y61_RS17255	COG3706	GGDEF domain
H1Y61_RS17260	COG0418	dihydroorotase activity
H1Y61_RS17280	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS17285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Y61_RS17290	COG3938	Belongs to the proline racemase family
H1Y61_RS17300	COG0427	acetyl-CoA hydrolase
H1Y61_RS17320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1Y61_RS17330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1Y61_RS17335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H1Y61_RS17345	COG2986	histidine ammonia-lyase
H1Y61_RS17350	COG2188	Transcriptional regulator
H1Y61_RS17370	COG0517	IMP dehydrogenase activity
H1Y61_RS17370	COG1125	glycine betaine transport
H1Y61_RS17390	COG2326	polyphosphate kinase activity
H1Y61_RS17395	COG5002	protein histidine kinase activity
H1Y61_RS17405	COG0573	inorganic phosphate transmembrane transporter activity
H1Y61_RS17415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1Y61_RS17420	COG0704	Plays a role in the regulation of phosphate uptake
H1Y61_RS17425	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS17435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1Y61_RS17440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H1Y61_RS17465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Y61_RS17470	COG2171	N-acyltransferase activity
H1Y61_RS17495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Y61_RS17500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H1Y61_RS17515	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H1Y61_RS17520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H1Y61_RS17525	COG0706	membrane insertase activity
H1Y61_RS17530	COG0594	ribonuclease P activity
H1Y61_RS17535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H1Y61_RS17540	COG2205	protein histidine kinase activity
H1Y61_RS17550	COG0840	transmembrane signaling receptor activity
H1Y61_RS17565	COG0069	glutamate synthase activity
H1Y61_RS17570	COG2218	PFAM glutamate synthase alpha subunit domain protein
H1Y61_RS17575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1Y61_RS17585	COG4977	sequence-specific DNA binding
H1Y61_RS17590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS17595	COG4311	Sarcosine oxidase, delta subunit
H1Y61_RS17600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Y61_RS17600	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1Y61_RS17625	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS17630	COG1175	transmembrane transport
H1Y61_RS17665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Y61_RS17680	COG0626	cystathionine gamma-synthase activity
H1Y61_RS17700	COG3386	PFAM SMP-30 Gluconolaconase
H1Y61_RS17710	COG2084	Dehydrogenase
H1Y61_RS17715	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS17720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS17730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H1Y61_RS17740	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS17745	COG1175	transmembrane transport
H1Y61_RS17750	COG3842	ATPase activity
H1Y61_RS17760	COG0640	Transcriptional regulator
H1Y61_RS17770	COG2186	Transcriptional regulator
H1Y61_RS17775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS17780	COG0747	negative chemotaxis
H1Y61_RS17785	COG0601	transmembrane transport
H1Y61_RS17790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS17795	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS17805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Y61_RS17810	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1Y61_RS17810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Y61_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS17825	COG1566	PFAM secretion protein HlyD family protein
H1Y61_RS17845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1Y61_RS17845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1Y61_RS17860	COG4770	biotin carboxylase activity
H1Y61_RS17875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1Y61_RS17890	COG1309	transcriptional regulator
H1Y61_RS17895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Y61_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS17910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS17940	COG0601	transmembrane transport
H1Y61_RS17945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS17950	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS17975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1Y61_RS17990	COG1129	ABC transporter
H1Y61_RS17995	COG1335	isochorismatase
H1Y61_RS18010	COG0154	amidase activity
H1Y61_RS18025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS18035	COG0747	negative chemotaxis
H1Y61_RS18040	COG0583	DNA-binding transcription factor activity
H1Y61_RS18060	COG0747	negative chemotaxis
H1Y61_RS18080	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS18090	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS18110	COG3321	synthase
H1Y61_RS18110	COG0604	alcohol dehydrogenase
H1Y61_RS18140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1Y61_RS18155	COG3833	ABC-type maltose transport systems, permease component
H1Y61_RS18160	COG3842	ATPase activity
H1Y61_RS18175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Y61_RS18175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Y61_RS18180	COG1132	(ABC) transporter
H1Y61_RS18200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Y61_RS18205	COG5001	Diguanylate cyclase
H1Y61_RS18235	COG3685	Protein conserved in bacteria
H1Y61_RS18250	COG3920	Histidine kinase
H1Y61_RS18255	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H1Y61_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS18275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H1Y61_RS18285	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS18295	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS18300	COG1175	transmembrane transport
H1Y61_RS18310	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS18320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS18335	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS18345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1Y61_RS18350	COG1278	Cold shock
H1Y61_RS18355	COG1640	4-alpha-glucanotransferase
H1Y61_RS18360	COG0366	Alpha amylase catalytic
H1Y61_RS18365	COG0366	Alpha amylase catalytic
H1Y61_RS18370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Y61_RS18375	COG0789	Transcriptional regulator
H1Y61_RS18385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Y61_RS18400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS18410	COG0835	chemotaxis
H1Y61_RS18415	COG0840	transmembrane signaling receptor activity
H1Y61_RS18415	COG2972	Histidine kinase
H1Y61_RS18420	COG1609	Transcriptional regulator
H1Y61_RS18425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Y61_RS18430	COG1126	abc transporter atp-binding protein
H1Y61_RS18445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Y61_RS18450	COG0784	Response regulator, receiver
H1Y61_RS18450	COG4191	Histidine kinase
H1Y61_RS18455	COG1162	GTPase activity
H1Y61_RS18465	COG0784	Response regulator, receiver
H1Y61_RS18475	COG2202	Pas domain
H1Y61_RS18475	COG3920	Histidine kinase
H1Y61_RS18490	COG1215	transferase activity, transferring glycosyl groups
H1Y61_RS18505	COG2076	Multidrug Resistance protein
H1Y61_RS18525	COG2076	Multidrug Resistance protein
H1Y61_RS18535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS18545	COG2205	protein histidine kinase activity
H1Y61_RS18550	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS18555	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS18565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS18570	COG0601	transmembrane transport
H1Y61_RS18575	COG0747	negative chemotaxis
H1Y61_RS18580	COG1940	carbohydrate kinase activity
H1Y61_RS18615	COG1175	transmembrane transport
H1Y61_RS18620	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS18625	COG3842	ATPase activity
H1Y61_RS18635	COG4566	intracellular signal transduction
H1Y61_RS18640	COG4191	Histidine kinase
H1Y61_RS18650	COG1116	anion transmembrane transporter activity
H1Y61_RS18660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Y61_RS18680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Y61_RS18715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS18740	COG1959	2 iron, 2 sulfur cluster binding
H1Y61_RS18745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS18750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS18755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS18765	COG1116	anion transmembrane transporter activity
H1Y61_RS18780	COG1764	response to oxidative stress
H1Y61_RS18790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Y61_RS18795	COG0765	amino acid transport
H1Y61_RS18800	COG0765	amino acid transport
H1Y61_RS18805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Y61_RS18810	COG1126	abc transporter atp-binding protein
H1Y61_RS18815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1Y61_RS18820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1Y61_RS18865	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Y61_RS18875	COG1304	FMN binding
H1Y61_RS18880	COG2186	Transcriptional regulator
H1Y61_RS18895	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS18900	COG2080	2 iron, 2 sulfur cluster binding
H1Y61_RS18905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Y61_RS18920	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1Y61_RS18935	COG0583	DNA-binding transcription factor activity
H1Y61_RS18940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1Y61_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS18990	COG2116	formate transmembrane transporter activity
H1Y61_RS18995	COG1940	carbohydrate kinase activity
H1Y61_RS19000	COG3250	beta-galactosidase activity
H1Y61_RS19005	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS19010	COG0583	DNA-binding transcription factor activity
H1Y61_RS19025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1Y61_RS19035	COG3842	ATPase activity
H1Y61_RS19040	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS19045	COG1175	transmembrane transport
H1Y61_RS19050	COG1653	transport
H1Y61_RS19060	COG0673	inositol 2-dehydrogenase activity
H1Y61_RS19065	COG1609	Transcriptional regulator
H1Y61_RS19070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1Y61_RS19075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1Y61_RS19080	COG4208	sulfate ABC transporter
H1Y61_RS19085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1Y61_RS19100	COG4585	Histidine kinase
H1Y61_RS19105	COG2197	response regulator
H1Y61_RS19110	COG2205	protein histidine kinase activity
H1Y61_RS19120	COG0747	negative chemotaxis
H1Y61_RS19150	COG0601	transmembrane transport
H1Y61_RS19160	COG1802	Transcriptional regulator
H1Y61_RS19170	COG0318	PFAM AMP-dependent synthetase and ligase
H1Y61_RS19185	COG3789	protein conserved in bacteria
H1Y61_RS19195	COG3766	membrane
H1Y61_RS19205	COG0754	glutathionylspermidine amidase activity
H1Y61_RS19215	COG0405	Gamma-glutamyltransferase
H1Y61_RS19225	COG0601	transmembrane transport
H1Y61_RS19230	COG0747	negative chemotaxis
H1Y61_RS19240	COG0006	proline dipeptidase activity
H1Y61_RS19245	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS19250	COG0444	Belongs to the ABC transporter superfamily
H1Y61_RS19265	COG0747	negative chemotaxis
H1Y61_RS19270	COG1725	Transcriptional regulator
H1Y61_RS19275	COG0626	cystathionine gamma-synthase activity
H1Y61_RS19285	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS19305	COG2390	Transcriptional regulator
H1Y61_RS19310	COG3684	Belongs to the aldolase LacD family
H1Y61_RS19335	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS19340	COG1175	transmembrane transport
H1Y61_RS19345	COG3842	ATPase activity
H1Y61_RS19350	COG0306	phosphate transporter
H1Y61_RS19355	COG0753	catalase activity
H1Y61_RS19365	COG0438	transferase activity, transferring glycosyl groups
H1Y61_RS19375	COG2133	pyrroloquinoline quinone binding
H1Y61_RS19395	COG0625	glutathione transferase activity
H1Y61_RS19425	COG1846	Transcriptional regulator
H1Y61_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS19435	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS19455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS19460	COG0601	transmembrane transport
H1Y61_RS19490	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS19520	COG0583	DNA-binding transcription factor activity
H1Y61_RS19525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1Y61_RS19530	COG3842	ATPase activity
H1Y61_RS19535	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Y61_RS19540	COG1177	transmembrane transport
H1Y61_RS19545	COG2072	flavoprotein involved in K transport
H1Y61_RS19560	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS19565	COG0402	S-adenosylhomocysteine deaminase activity
H1Y61_RS19600	COG2111	Na H antiporter
H1Y61_RS19600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1Y61_RS19605	COG1006	Multisubunit Na H antiporter MnhC subunit
H1Y61_RS19610	COG0651	ATP synthesis coupled electron transport
H1Y61_RS19615	COG1863	multisubunit Na H antiporter MnhE subunit
H1Y61_RS19620	COG2212	antiporter activity
H1Y61_RS19625	COG1320	monovalent cation:proton antiporter activity
H1Y61_RS19665	COG0584	glycerophosphoryl diester phosphodiesterase
H1Y61_RS19670	COG3842	ATPase activity
H1Y61_RS19675	COG3833	ABC-type maltose transport systems, permease component
H1Y61_RS19700	COG2824	Alkylphosphonate utilization operon protein PhnA
H1Y61_RS19705	COG1595	DNA-templated transcription, initiation
H1Y61_RS19735	COG0300	oxidoreductase activity
H1Y61_RS19755	COG0235	Class ii aldolase
H1Y61_RS19765	COG2207	Transcriptional regulator
H1Y61_RS19795	COG1309	transcriptional regulator
H1Y61_RS19805	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS19815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Y61_RS19835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS19845	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS19850	COG2205	protein histidine kinase activity
H1Y61_RS19855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS19880	COG1473	amidohydrolase
H1Y61_RS19885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS19890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS19895	COG1609	Transcriptional regulator
H1Y61_RS19900	COG2271	Major facilitator Superfamily
H1Y61_RS19905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS19910	COG2731	YhcH YjgK YiaL family protein
H1Y61_RS19920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H1Y61_RS19925	COG5002	protein histidine kinase activity
H1Y61_RS19925	COG3850	Histidine kinase
H1Y61_RS19930	COG2197	response regulator
H1Y61_RS19955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS19965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS19975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS19980	COG2079	MmgE PrpD family protein
H1Y61_RS19990	COG0765	amino acid transport
H1Y61_RS20005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS20010	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20020	COG1129	ABC transporter
H1Y61_RS20035	COG4213	ABC transporter substrate-binding protein
H1Y61_RS20040	COG1129	ABC transporter
H1Y61_RS20045	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20060	COG0667	Aldo Keto reductase
H1Y61_RS20085	COG2972	Histidine kinase
H1Y61_RS20085	COG0840	transmembrane signaling receptor activity
H1Y61_RS20100	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20115	COG1609	Transcriptional regulator
H1Y61_RS20135	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS20140	COG1175	transmembrane transport
H1Y61_RS20155	COG1129	ABC transporter
H1Y61_RS20160	COG4214	carbohydrate transport
H1Y61_RS20180	COG4948	Mandelate Racemase Muconate Lactonizing
H1Y61_RS20185	COG1063	alcohol dehydrogenase
H1Y61_RS20200	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS20215	COG2207	Transcriptional regulator
H1Y61_RS20215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H1Y61_RS20220	COG1486	melibiose metabolic process
H1Y61_RS20225	COG0747	negative chemotaxis
H1Y61_RS20230	COG0601	transmembrane transport
H1Y61_RS20235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS20240	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS20245	COG1486	melibiose metabolic process
H1Y61_RS20250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1Y61_RS20275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Y61_RS20280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1Y61_RS20285	COG2080	2 iron, 2 sulfur cluster binding
H1Y61_RS20300	COG3706	GGDEF domain
H1Y61_RS20300	COG2203	Gaf domain
H1Y61_RS20300	COG5001	Diguanylate cyclase
H1Y61_RS20300	COG4251	negative regulation of phosphorylation
H1Y61_RS20305	COG1921	L-seryl-tRNASec selenium transferase activity
H1Y61_RS20320	COG3964	amidohydrolase
H1Y61_RS20330	COG0601	transmembrane transport
H1Y61_RS20335	COG2723	6-phospho-beta-galactosidase activity
H1Y61_RS20345	COG1802	Transcriptional regulator
H1Y61_RS20360	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Y61_RS20420	COG0589	response to stress
H1Y61_RS20425	COG0659	secondary active sulfate transmembrane transporter activity
H1Y61_RS20430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Y61_RS20440	COG0778	Nitroreductase
H1Y61_RS20460	COG1116	anion transmembrane transporter activity
H1Y61_RS20465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS20475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1Y61_RS20485	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS20490	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS20495	COG2186	Transcriptional regulator
H1Y61_RS20500	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20505	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20510	COG1129	ABC transporter
H1Y61_RS20515	COG1879	ABC-type sugar transport system periplasmic component
H1Y61_RS20535	COG1129	ABC transporter
H1Y61_RS20550	COG1609	Transcriptional regulator
H1Y61_RS20560	COG2084	Dehydrogenase
H1Y61_RS20565	COG3265	gluconokinase activity
H1Y61_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS20575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Y61_RS20580	COG1063	alcohol dehydrogenase
H1Y61_RS20605	COG0297	glycogen (starch) synthase activity
H1Y61_RS20615	COG1473	amidohydrolase
H1Y61_RS20620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1Y61_RS20630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Y61_RS20635	COG2040	homocysteine
H1Y61_RS20645	COG4215	(ABC) transporter
H1Y61_RS20660	COG1522	sequence-specific DNA binding
H1Y61_RS20680	COG3257	ureidoglycine aminohydrolase activity
H1Y61_RS20690	COG0392	lysyltransferase activity
H1Y61_RS20695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1Y61_RS20700	COG1414	Transcriptional regulator
H1Y61_RS20705	COG1475	DNA binding
H1Y61_RS20710	COG1192	Involved in chromosome partitioning
H1Y61_RS20720	COG4303	Ethanolamine ammonia lyase large subunit
H1Y61_RS20735	COG4181	ATPase activity
H1Y61_RS20740	COG2094	Belongs to the DNA glycosylase MPG family
H1Y61_RS20760	COG3842	ATPase activity
H1Y61_RS20770	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Y61_RS20775	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS20785	COG5001	Diguanylate cyclase
H1Y61_RS20790	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Y61_RS20800	COG3254	rhamnose metabolic process
H1Y61_RS20810	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS20815	COG1129	ABC transporter
H1Y61_RS20830	COG3347	Dehydrogenase
H1Y61_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS20835	COG4952	isomerase
H1Y61_RS20850	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS20855	COG0642	Histidine kinase
H1Y61_RS20875	COG3142	Participates in the control of copper homeostasis
H1Y61_RS20880	COG2814	Major facilitator Superfamily
H1Y61_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS20900	COG1737	Transcriptional regulator
H1Y61_RS20900	COG0837	glucose binding
H1Y61_RS20925	COG3842	ATPase activity
H1Y61_RS20935	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS20950	COG2188	Transcriptional regulator
H1Y61_RS20955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1Y61_RS20960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H1Y61_RS20980	COG1309	transcriptional regulator
H1Y61_RS20985	COG2204	response regulator
H1Y61_RS20990	COG4191	Histidine kinase
H1Y61_RS20995	COG1301	dicarboxylic acid transport
H1Y61_RS21000	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H1Y61_RS21000	COG2273	Hydrolase Family 16
H1Y61_RS21015	COG0670	Belongs to the BI1 family
H1Y61_RS21025	COG1595	DNA-templated transcription, initiation
H1Y61_RS21035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1Y61_RS21040	COG1845	cytochrome c oxidase, subunit III
H1Y61_RS21045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1Y61_RS21050	COG3346	SURF1 family
H1Y61_RS21065	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS21070	COG2205	protein histidine kinase activity
H1Y61_RS21075	COG5265	(ABC) transporter
H1Y61_RS21090	COG0668	transmembrane transport
H1Y61_RS21105	COG3842	ATPase activity
H1Y61_RS21110	COG1674	ftsk spoiiie
H1Y61_RS21115	COG0604	alcohol dehydrogenase
H1Y61_RS21125	COG3485	protocatechuate 3,4-dioxygenase
H1Y61_RS21130	COG3485	protocatechuate 3,4-dioxygenase
H1Y61_RS21135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1Y61_RS21140	COG2267	carboxylic ester hydrolase activity
H1Y61_RS21145	COG0583	DNA-binding transcription factor activity
H1Y61_RS21160	COG1414	Transcriptional regulator
H1Y61_RS21170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1Y61_RS21175	COG0183	Belongs to the thiolase family
H1Y61_RS21210	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS21215	COG2205	protein histidine kinase activity
H1Y61_RS21225	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS21235	COG2721	sulfolactate sulfo-lyase activity
H1Y61_RS21255	COG1129	ABC transporter
H1Y61_RS21265	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS21275	COG4154	Belongs to the RbsD FucU family
H1Y61_RS21285	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS21290	COG3842	ATPase activity
H1Y61_RS21295	COG1177	transmembrane transport
H1Y61_RS21310	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS21315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS21325	COG2267	carboxylic ester hydrolase activity
H1Y61_RS21340	COG1522	sequence-specific DNA binding
H1Y61_RS21345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Y61_RS21350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS21375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1Y61_RS21385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H1Y61_RS21390	COG2205	protein histidine kinase activity
H1Y61_RS21395	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS21405	COG0431	NADPH-dependent FMN reductase
H1Y61_RS21415	COG0798	PFAM Bile acid sodium symporter
H1Y61_RS21420	COG0640	Transcriptional regulator
H1Y61_RS21555	COG3321	synthase
H1Y61_RS21555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Y61_RS21555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Y61_RS21555	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS21555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS21560	COG3321	synthase
H1Y61_RS21560	COG4221	oxidoreductase activity
H1Y61_RS21560	COG0300	oxidoreductase activity
H1Y61_RS21560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS21565	COG0367	asparagine synthase
H1Y61_RS21570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Y61_RS21575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1Y61_RS21575	COG2070	2-Nitropropane dioxygenase
H1Y61_RS21630	COG2022	thiamine diphosphate biosynthetic process
H1Y61_RS21645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H1Y61_RS21660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS21675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1Y61_RS21680	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS21685	COG0583	DNA-binding transcription factor activity
H1Y61_RS21705	COG3707	response regulator
H1Y61_RS21710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS21715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Y61_RS21720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Y61_RS21725	COG1116	anion transmembrane transporter activity
H1Y61_RS21730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1Y61_RS21740	COG0243	molybdopterin cofactor binding
H1Y61_RS21750	COG0659	secondary active sulfate transmembrane transporter activity
H1Y61_RS21760	COG1522	sequence-specific DNA binding
H1Y61_RS21775	COG0523	cobalamin synthesis protein
H1Y61_RS21785	COG0726	polysaccharide deacetylase
H1Y61_RS21790	COG3842	ATPase activity
H1Y61_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS21805	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS21815	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Y61_RS21820	COG3842	ATPase activity
H1Y61_RS21830	COG1984	allophanate hydrolase subunit 2
H1Y61_RS21840	COG0439	Biotin carboxylase
H1Y61_RS21845	COG0511	ligase activity, forming carbon-carbon bonds
H1Y61_RS21850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H1Y61_RS21855	COG0583	DNA-binding transcription factor activity
H1Y61_RS21865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Y61_RS21880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1Y61_RS21885	COG1522	sequence-specific DNA binding
H1Y61_RS21890	COG1802	Transcriptional regulator
H1Y61_RS21895	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Y61_RS21900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H1Y61_RS21905	COG4336	lyase activity
H1Y61_RS21910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H1Y61_RS21915	COG4770	biotin carboxylase activity
H1Y61_RS21925	COG0019	diaminopimelate decarboxylase activity
H1Y61_RS21930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1Y61_RS21935	COG1177	transmembrane transport
H1Y61_RS21940	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Y61_RS21950	COG3842	ATPase activity
H1Y61_RS21970	COG0459	protein refolding
H1Y61_RS21975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H1Y61_RS21980	COG2059	Chromate
H1Y61_RS21990	COG0196	riboflavin kinase activity
H1Y61_RS22005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1Y61_RS22020	COG2130	NADP-dependent
H1Y61_RS22025	COG2137	regulation of response to DNA damage stimulus
H1Y61_RS22035	COG2909	trisaccharide binding
H1Y61_RS22040	COG1376	ErfK ybiS ycfS ynhG family protein
H1Y61_RS22045	COG1388	LysM domain
H1Y61_RS22045	COG1376	ErfK ybiS ycfS ynhG family protein
H1Y61_RS22050	COG2818	Glycosylase
H1Y61_RS22080	COG0124	histidyl-tRNA synthetase
H1Y61_RS22095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H1Y61_RS22100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1Y61_RS22110	COG0625	glutathione transferase activity
H1Y61_RS22120	COG0247	lactate metabolic process
H1Y61_RS22130	COG0277	FAD linked oxidase domain protein
H1Y61_RS22135	COG0277	FAD linked oxidase domain protein
H1Y61_RS22150	COG0306	phosphate transporter
H1Y61_RS22175	COG0583	DNA-binding transcription factor activity
H1Y61_RS22185	COG0583	DNA-binding transcription factor activity
H1Y61_RS22195	COG0412	Dienelactone hydrolase
H1Y61_RS22210	COG1609	Transcriptional regulator
H1Y61_RS22215	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS22220	COG1175	transmembrane transport
H1Y61_RS22235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Y61_RS22250	COG1304	FMN binding
H1Y61_RS22300	COG0243	molybdopterin cofactor binding
H1Y61_RS22325	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS22340	COG1309	transcriptional regulator
H1Y61_RS22350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Y61_RS22385	COG1940	carbohydrate kinase activity
H1Y61_RS22390	COG3842	ATPase activity
H1Y61_RS22395	COG1177	transmembrane transport
H1Y61_RS22415	COG3485	protocatechuate 3,4-dioxygenase
H1Y61_RS22475	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Y61_RS22495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Y61_RS22500	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Y61_RS22510	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS22525	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS22530	COG2271	Major facilitator Superfamily
H1Y61_RS22540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1Y61_RS22560	COG1414	Transcriptional regulator
H1Y61_RS22575	COG1960	acyl-CoA dehydrogenase activity
H1Y61_RS22585	COG1414	Transcriptional regulator
H1Y61_RS22600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Y61_RS22650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS22680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1Y61_RS22690	COG1522	sequence-specific DNA binding
H1Y61_RS22700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Y61_RS22710	COG1177	transmembrane transport
H1Y61_RS22720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1Y61_RS22725	COG3842	ATPase activity
H1Y61_RS22745	COG2186	Transcriptional regulator
H1Y61_RS22775	COG2814	Major facilitator Superfamily
H1Y61_RS22780	COG4264	IucA IucC family
H1Y61_RS22785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H1Y61_RS22790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1Y61_RS22795	COG0019	diaminopimelate decarboxylase activity
H1Y61_RS22800	COG1475	DNA binding
H1Y61_RS22870	COG4977	sequence-specific DNA binding
H1Y61_RS22870	COG1917	Cupin 2, conserved barrel domain protein
H1Y61_RS22925	COG2814	Major facilitator Superfamily
H1Y61_RS22930	COG0583	DNA-binding transcription factor activity
H1Y61_RS22940	COG4977	sequence-specific DNA binding
H1Y61_RS22975	COG3706	GGDEF domain
H1Y61_RS22985	COG0640	Transcriptional regulator
H1Y61_RS22990	COG1475	DNA binding
H1Y61_RS22995	COG1192	Involved in chromosome partitioning
H1Y61_RS23020	COG0765	amino acid transport
H1Y61_RS23035	COG1802	Transcriptional regulator
H1Y61_RS23045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS23065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Y61_RS23070	COG1349	DNA-binding transcription factor activity
H1Y61_RS23075	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS23080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS23085	COG0601	transmembrane transport
H1Y61_RS23160	COG1120	ATPase activity
H1Y61_RS23165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Y61_RS23170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Y61_RS23175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H1Y61_RS23180	COG4774	siderophore transport
H1Y61_RS23180	COG1629	transport
H1Y61_RS23230	COG2226	methyltransferase
H1Y61_RS23240	COG0318	PFAM AMP-dependent synthetase and ligase
H1Y61_RS23260	COG0534	Mate efflux family protein
H1Y61_RS23285	COG0840	transmembrane signaling receptor activity
H1Y61_RS23300	COG1446	asparaginase
H1Y61_RS23305	COG2362	D-Aminopeptidase
H1Y61_RS23310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Y61_RS23320	COG0747	negative chemotaxis
H1Y61_RS23325	COG4172	Belongs to the ABC transporter superfamily
H1Y61_RS23340	COG1940	carbohydrate kinase activity
H1Y61_RS23350	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS23355	COG1175	transmembrane transport
H1Y61_RS23370	COG0110	maltose O-acetyltransferase activity
H1Y61_RS23390	COG3842	ATPase activity
H1Y61_RS23400	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS23405	COG1175	transmembrane transport
H1Y61_RS23420	COG2186	Transcriptional regulator
H1Y61_RS23435	COG3842	ATPase activity
H1Y61_RS23445	COG1175	transmembrane transport
H1Y61_RS23450	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS23460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Y61_RS23475	COG1129	ABC transporter
H1Y61_RS23480	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS23485	COG1737	Transcriptional regulator
H1Y61_RS23500	COG3177	Filamentation induced by cAMP protein fic
H1Y61_RS23505	COG1069	ribulokinase activity
H1Y61_RS23525	COG3547	Transposase (IS116 IS110 IS902 family)
H1Y61_RS23545	COG3938	Belongs to the proline racemase family
H1Y61_RS23550	COG4176	ABC-type proline glycine betaine transport system permease component
H1Y61_RS23555	COG4176	ABC-type proline glycine betaine transport system permease component
H1Y61_RS23560	COG4175	Glycine betaine
H1Y61_RS23560	COG3448	diguanylate cyclase activity
H1Y61_RS23570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Y61_RS23575	COG1012	belongs to the aldehyde dehydrogenase family
H1Y61_RS23580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Y61_RS23585	COG2186	Transcriptional regulator
H1Y61_RS23590	COG1802	Transcriptional regulator
H1Y61_RS23605	COG0583	DNA-binding transcription factor activity
H1Y61_RS23615	COG1573	uracil-dna glycosylase
H1Y61_RS23635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Y61_RS23655	COG1024	Enoyl-CoA hydratase
H1Y61_RS23660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1Y61_RS23670	COG0318	PFAM AMP-dependent synthetase and ligase
H1Y61_RS23690	COG2124	cytochrome p450
H1Y61_RS23725	COG0277	FAD linked oxidase domain protein
H1Y61_RS23730	COG2181	nitrate reductase activity
H1Y61_RS23730	COG0247	lactate metabolic process
H1Y61_RS23760	COG1063	alcohol dehydrogenase
H1Y61_RS23765	COG3284	Transcriptional regulator
H1Y61_RS23820	COG0662	Cupin 2, conserved barrel domain protein
H1Y61_RS23820	COG2207	Transcriptional regulator
H1Y61_RS23825	COG0243	molybdopterin cofactor binding
H1Y61_RS23830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1Y61_RS23845	COG1609	Transcriptional regulator
H1Y61_RS23860	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS23865	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H1Y61_RS23905	COG0745	RESPONSE REGULATOR receiver
H1Y61_RS23910	COG2205	protein histidine kinase activity
H1Y61_RS23945	COG2826	transposase and inactivated derivatives, IS30 family
H1Y61_RS24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS24055	COG1129	ABC transporter
H1Y61_RS24060	COG1028	Short-chain dehydrogenase reductase Sdr
H1Y61_RS24065	COG3265	gluconokinase activity
H1Y61_RS24110	COG3621	Patatin-like phospholipase
H1Y61_RS24115	COG1396	sequence-specific DNA binding
H1Y61_RS24145	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Y61_RS24170	COG3437	response regulator, receiver
H1Y61_RS24170	COG2205	protein histidine kinase activity
H1Y61_RS24170	COG3850	Histidine kinase
H1Y61_RS24170	COG4999	Histidine kinase
H1Y61_RS24175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Y61_RS24185	COG5002	protein histidine kinase activity
H1Y61_RS24200	COG0840	transmembrane signaling receptor activity
H1Y61_RS24200	COG2972	Histidine kinase
H1Y61_RS24205	COG3344	reverse transcriptase
H1Y61_RS24215	COG4251	negative regulation of phosphorylation
H1Y61_RS24225	COG0840	transmembrane signaling receptor activity
H1Y61_RS24280	COG1396	sequence-specific DNA binding
H1Y61_RS24330	COG4297	protein containing double-stranded beta helix domain
H1Y61_RS24420	COG1522	sequence-specific DNA binding
H1Y61_RS24470	COG0784	Response regulator, receiver
H1Y61_RS24470	COG4191	Histidine kinase
H1Y61_RS24505	COG0784	Response regulator, receiver
H1Y61_RS24505	COG4191	Histidine kinase
H1Y61_RS24565	COG2198	Histidine kinase
H1Y61_RS24565	COG0784	Response regulator, receiver
H1Y61_RS24565	COG2205	protein histidine kinase activity
H1Y61_RS24575	COG0784	Response regulator, receiver
H1Y61_RS24575	COG0643	Histidine kinase
H1Y61_RS24575	COG2198	Histidine kinase
H1Y61_RS24580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Y61_RS24585	COG2201	protein-glutamate methylesterase activity
H1Y61_RS24590	COG0835	chemotaxis
H1Y61_RS24620	COG2205	protein histidine kinase activity
H1Y61_RS24660	COG0776	regulation of translation
H1Y61_RS24700	COG0235	Class ii aldolase
H1Y61_RS24710	COG2814	Major facilitator Superfamily
H1Y61_RS24715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Y61_RS24745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1Y61_RS24795	COG0640	Transcriptional regulator
H1Y61_RS24800	COG1475	DNA binding
H1Y61_RS24805	COG1192	Involved in chromosome partitioning
H1Y61_RS24815	COG4962	Type ii secretion system protein e
H1Y61_RS24830	COG3451	type IV secretory pathway VirB4
H1Y61_RS24835	COG5314	conjugation
H1Y61_RS24845	COG3846	protein secretion by the type IV secretion system
H1Y61_RS24850	COG3701	Conjugal transfer protein
H1Y61_RS24955	COG1475	DNA binding
H1Y61_RS24970	COG0300	oxidoreductase activity
H1Y61_RS24980	COG5489	Protein of unknown function (DUF736)
H1Y61_RS24985	COG0776	regulation of translation
H1Y61_RS25040	COG2826	transposase and inactivated derivatives, IS30 family
H1Y61_RS25060	COG3547	Transposase (IS116 IS110 IS902 family)
H1Y61_RS25090	COG0667	Aldo Keto reductase
H1Y61_RS25105	COG1301	dicarboxylic acid transport
H1Y61_RS25115	COG2188	Transcriptional regulator
H1Y61_RS25120	COG3668	Plasmid stabilization system
H1Y61_RS25125	COG3609	addiction module antidote protein, CC2985 family
H1Y61_RS25150	COG0071	Belongs to the small heat shock protein (HSP20) family
H1Y61_RS25155	COG1942	4-Oxalocrotonate Tautomerase
H1Y61_RS25190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1Y61_RS25220	COG1278	Cold shock
H1Y61_RS25265	COG1475	DNA binding
H1Y61_RS25280	COG0300	oxidoreductase activity
H1Y61_RS25290	COG5489	Protein of unknown function (DUF736)
H1Y61_RS25310	COG3831	ATPase activity
H1Y61_RS25335	COG3501	Rhs element vgr protein
H1Y61_RS25405	COG2963	transposase activity
H1Y61_RS25415	COG4372	Transposase
H1Y61_RS25435	COG1396	sequence-specific DNA binding
H1Y61_RS25450	COG2207	Transcriptional regulator
H1Y61_RS25470	COG4598	ABC transporter
H1Y61_RS25485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Y61_RS25505	COG1609	Transcriptional regulator
H1Y61_RS25510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1Y61_RS25550	COG1487	ribonuclease activity
H1Y61_RS25555	COG4691	Plasmid stability protein
H1Y61_RS25560	COG0640	Transcriptional regulator
H1Y61_RS25565	COG1475	DNA binding
H1Y61_RS25570	COG1192	Involved in chromosome partitioning
H1Y61_RS25580	COG0640	Transcriptional regulator
H1Y61_RS25585	COG1475	DNA binding
H1Y61_RS25590	COG1192	Involved in chromosome partitioning
H1Y61_RS25595	COG3831	ATPase activity
H1Y61_RS25615	COG1196	nuclear chromosome segregation
H1Y61_RS25615	COG0739	heme binding
H1Y61_RS25615	COG0741	lytic transglycosylase activity
H1Y61_RS25675	COG1609	Transcriptional regulator
H1Y61_RS25685	COG1175	transmembrane transport
H1Y61_RS25690	COG0395	ABC-type sugar transport system, permease component
H1Y61_RS25700	COG3842	ATPase activity
H1Y61_RS25705	COG3842	ATPase activity
H1Y61_RS25765	COG1192	Involved in chromosome partitioning
H1Y61_RS25790	COG1858	cytochrome C peroxidase
H1Y61_RS25800	COG0583	DNA-binding transcription factor activity
H1Y61_RS25835	COG0411	ABC transporter
H1Y61_RS25840	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Y61_RS25850	COG0154	amidase activity
H1Y61_RS25880	COG0747	negative chemotaxis
H1Y61_RS25900	COG4608	Belongs to the ABC transporter superfamily
H1Y61_RS25910	COG2423	ornithine cyclodeaminase activity
H1Y61_RS25940	COG1917	Cupin 2, conserved barrel domain protein
H1Y61_RS25940	COG2207	Transcriptional regulator
H1Y61_RS25945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Y61_RS25950	COG1136	(ABC) transporter
H1Y61_RS25985	COG1475	DNA binding
H1Y61_RS26015	COG2184	nucleotidyltransferase activity
H1Y61_RS26020	COG4227	nucleotidyltransferase activity
H1Y61_RS26025	COG1192	Involved in chromosome partitioning
H1Y61_RS26030	COG1475	DNA binding
H1Y61_RS26035	COG0640	Transcriptional regulator
H1Y61_RS26045	COG3706	GGDEF domain
H1Y61_RS26090	COG2815	serine threonine protein kinase
H1Y61_RS26090	COG0515	serine threonine protein kinase
H1Y61_RS26095	COG0515	serine threonine protein kinase
H1Y61_RS26140	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H1Y61_RS26170	COG0741	lytic transglycosylase activity
H1Y61_RS26175	COG3451	type IV secretory pathway VirB4
H1Y61_RS26185	COG3838	Conjugal transfer protein Trbc
H1Y61_RS26190	COG0741	lytic transglycosylase activity
H1Y61_RS26230	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Y61_RS26235	COG0789	Transcriptional regulator
H1Y61_RS26315	COG0789	Transcriptional regulator
H1Y61_RS26345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS26410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Y61_RS26440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1Y61_RS26530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Y61_RS26570	COG5002	protein histidine kinase activity
H1Y61_RS26620	COG0789	Transcriptional regulator
H1Y61_RS26645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family