locus-tag	class	description
H1Z14_RS00005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1Z14_RS00020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1Z14_RS00025	COG3665	Urea carboxylase-associated protein
H1Z14_RS00035	COG4770	biotin carboxylase activity
H1Z14_RS00055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1Z14_RS00060	COG2153	protein acetylation
H1Z14_RS00065	COG1671	Belongs to the UPF0178 family
H1Z14_RS00075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H1Z14_RS00080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Z14_RS00090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Z14_RS00095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Z14_RS00100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Z14_RS00105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1Z14_RS00110	COG0750	zinc metalloprotease
H1Z14_RS00120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1Z14_RS00125	COG0233	cytoplasmic translational termination
H1Z14_RS00130	COG0528	UMP kinase activity
H1Z14_RS00135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H1Z14_RS00140	COG0052	Belongs to the universal ribosomal protein uS2 family
H1Z14_RS00165	COG0537	adenosine 5'-monophosphoramidase activity
H1Z14_RS00185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1Z14_RS00210	COG2267	carboxylic ester hydrolase activity
H1Z14_RS00230	COG0626	cystathionine gamma-synthase activity
H1Z14_RS00235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS00240	COG4597	amino acid ABC transporter
H1Z14_RS00245	COG0765	amino acid transport
H1Z14_RS00250	COG1126	abc transporter atp-binding protein
H1Z14_RS00255	COG0154	amidase activity
H1Z14_RS00260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1Z14_RS00265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H1Z14_RS00275	COG2313	pseudouridylate synthase activity
H1Z14_RS00280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1Z14_RS00285	COG2333	competence protein COMEC
H1Z14_RS00285	COG0658	competence protein
H1Z14_RS00290	COG0372	Belongs to the citrate synthase family
H1Z14_RS00300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1Z14_RS00305	COG0134	indole-3-glycerol-phosphate synthase activity
H1Z14_RS00310	COG0315	cyclic pyranopterin monophosphate synthase activity
H1Z14_RS00315	COG0303	'Molybdopterin
H1Z14_RS00320	COG0671	phosphoesterase, PA-phosphatase related
H1Z14_RS00325	COG1492	cobalamin metabolic process
H1Z14_RS00340	COG4176	ABC-type proline glycine betaine transport system permease component
H1Z14_RS00345	COG0517	IMP dehydrogenase activity
H1Z14_RS00345	COG4175	Glycine betaine
H1Z14_RS00365	COG3698	Phosphodiester glycosidase
H1Z14_RS00390	COG0583	DNA-binding transcription factor activity
H1Z14_RS00420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Z14_RS00445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1Z14_RS00455	COG0840	transmembrane signaling receptor activity
H1Z14_RS00465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H1Z14_RS00475	COG1058	Belongs to the CinA family
H1Z14_RS00475	COG1546	Belongs to the CinA family
H1Z14_RS00480	COG2972	Histidine kinase
H1Z14_RS00480	COG0840	transmembrane signaling receptor activity
H1Z14_RS00490	COG0835	chemotaxis
H1Z14_RS00500	COG1760	l-serine dehydratase
H1Z14_RS00525	COG2239	Acts as a magnesium transporter
H1Z14_RS00550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H1Z14_RS00555	COG2099	Precorrin-6x reductase
H1Z14_RS00560	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H1Z14_RS00575	COG2875	Belongs to the precorrin methyltransferase family
H1Z14_RS00600	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H1Z14_RS00655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H1Z14_RS00680	COG1862	Preprotein translocase
H1Z14_RS00695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Z14_RS00700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1Z14_RS00705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1Z14_RS00710	COG0805	protein transport
H1Z14_RS00720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1Z14_RS00725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1Z14_RS00730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1Z14_RS00735	COG1472	Belongs to the glycosyl hydrolase 3 family
H1Z14_RS00745	COG0018	arginyl-trna synthetase
H1Z14_RS00750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H1Z14_RS00755	COG0316	Belongs to the HesB IscA family
H1Z14_RS00775	COG0525	valine-tRNA ligase activity
H1Z14_RS00790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Z14_RS00815	COG0584	glycerophosphoryl diester phosphodiesterase
H1Z14_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS00865	COG0583	DNA-binding transcription factor activity
H1Z14_RS00875	COG3842	ATPase activity
H1Z14_RS00880	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS00885	COG1177	transmembrane transport
H1Z14_RS00905	COG0251	oxidation-reduction process
H1Z14_RS00940	COG0842	Transport permease protein
H1Z14_RS00945	COG1131	(ABC) transporter
H1Z14_RS00950	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS00965	COG2226	methyltransferase
H1Z14_RS00970	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H1Z14_RS00970	COG3264	Mechanosensitive ion channel
H1Z14_RS00990	COG4558	Periplasmic binding protein
H1Z14_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS01000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1Z14_RS01160	COG3750	Belongs to the UPF0335 family
H1Z14_RS01280	COG0384	phenazine biosynthesis protein PhzF
H1Z14_RS01305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H1Z14_RS01315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1Z14_RS01330	COG1522	sequence-specific DNA binding
H1Z14_RS01335	COG1794	racemase activity, acting on amino acids and derivatives
H1Z14_RS01340	COG1309	transcriptional regulator
H1Z14_RS01345	COG2814	Major facilitator Superfamily
H1Z14_RS01355	COG1733	regulation of RNA biosynthetic process
H1Z14_RS01365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1Z14_RS01375	COG0789	Transcriptional regulator
H1Z14_RS01380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Z14_RS01390	COG0656	L-ascorbic acid biosynthetic process
H1Z14_RS01405	COG0028	Belongs to the TPP enzyme family
H1Z14_RS01425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H1Z14_RS01430	COG0560	Phosphoserine phosphatase
H1Z14_RS01445	COG0330	HflC and HflK could
H1Z14_RS01460	COG2259	Doxx family
H1Z14_RS01465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H1Z14_RS01500	COG0277	FAD linked oxidase domain protein
H1Z14_RS01505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1Z14_RS01510	COG0581	inorganic phosphate transmembrane transporter activity
H1Z14_RS01515	COG0573	inorganic phosphate transmembrane transporter activity
H1Z14_RS01520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1Z14_RS01550	COG4993	Dehydrogenase
H1Z14_RS01555	COG1335	isochorismatase
H1Z14_RS01560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H1Z14_RS01565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H1Z14_RS01575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1Z14_RS01610	COG2264	protein methyltransferase activity
H1Z14_RS01615	COG1999	signal sequence binding
H1Z14_RS01620	COG0840	transmembrane signaling receptor activity
H1Z14_RS01625	COG0835	chemotaxis
H1Z14_RS01640	COG2176	DNA-directed DNA polymerase activity
H1Z14_RS01645	COG0840	transmembrane signaling receptor activity
H1Z14_RS01650	COG0456	acetyltransferase
H1Z14_RS01680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1Z14_RS01690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1Z14_RS01700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1Z14_RS01710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1Z14_RS01715	COG0849	cell division
H1Z14_RS01720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1Z14_RS01725	COG1181	Belongs to the D-alanine--D-alanine ligase family
H1Z14_RS01730	COG0477	Major facilitator Superfamily
H1Z14_RS01735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H1Z14_RS01740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1Z14_RS01745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1Z14_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H1Z14_RS01760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1Z14_RS01770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1Z14_RS01785	COG0275	rRNA processing
H1Z14_RS01790	COG2001	Belongs to the MraZ family
H1Z14_RS01810	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1Z14_RS01875	COG2226	methyltransferase
H1Z14_RS01880	COG0840	transmembrane signaling receptor activity
H1Z14_RS01885	COG2972	Histidine kinase
H1Z14_RS01885	COG0840	transmembrane signaling receptor activity
H1Z14_RS01900	COG2267	carboxylic ester hydrolase activity
H1Z14_RS01905	COG0697	spore germination
H1Z14_RS01910	COG0028	Belongs to the TPP enzyme family
H1Z14_RS01920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1Z14_RS01925	COG0251	oxidation-reduction process
H1Z14_RS01940	COG1376	ErfK ybiS ycfS ynhG family protein
H1Z14_RS01965	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1Z14_RS01970	COG4149	molybdate abc transporter
H1Z14_RS01975	COG3842	ATPase activity
H1Z14_RS01990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Z14_RS01995	COG2197	response regulator
H1Z14_RS02000	COG1396	sequence-specific DNA binding
H1Z14_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1Z14_RS02050	COG0697	spore germination
H1Z14_RS02060	COG2968	Membrane
H1Z14_RS02150	COG4387	Mu-like prophage protein GP36
H1Z14_RS02160	COG4397	Mu-like prophage major head subunit gpT
H1Z14_RS02180	COG4383	Mu-like prophage protein gp29
H1Z14_RS02185	COG4373	Mu-like prophage FluMu protein gp28
H1Z14_RS02320	COG1475	DNA binding
H1Z14_RS02470	COG1278	Cold shock
H1Z14_RS02500	COG0432	Pfam Uncharacterised protein family UPF0047
H1Z14_RS02515	COG0583	DNA-binding transcription factor activity
H1Z14_RS02540	COG1473	amidohydrolase
H1Z14_RS02570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1Z14_RS02580	COG1268	BioY protein
H1Z14_RS02585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H1Z14_RS02595	COG0505	Belongs to the CarA family
H1Z14_RS02600	COG0534	Mate efflux family protein
H1Z14_RS02605	COG0583	DNA-binding transcription factor activity
H1Z14_RS02610	COG0667	Aldo Keto reductase
H1Z14_RS02615	COG2321	neutral zinc metallopeptidase
H1Z14_RS02635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H1Z14_RS02645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1Z14_RS02675	COG4641	Protein conserved in bacteria
H1Z14_RS02675	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS02680	COG1522	sequence-specific DNA binding
H1Z14_RS02685	COG0492	ferredoxin-NADP+ reductase activity
H1Z14_RS02690	COG0583	DNA-binding transcription factor activity
H1Z14_RS02695	COG0640	Transcriptional regulator
H1Z14_RS02700	COG1902	pentaerythritol trinitrate reductase activity
H1Z14_RS02720	COG0387	Pfam Sodium calcium exchanger
H1Z14_RS02730	COG0436	Aminotransferase
H1Z14_RS02750	COG1278	Cold shock
H1Z14_RS02755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Z14_RS02765	COG1846	Transcriptional regulator
H1Z14_RS02770	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS02775	COG2205	protein histidine kinase activity
H1Z14_RS02780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Z14_RS02800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H1Z14_RS02815	COG0006	proline dipeptidase activity
H1Z14_RS02840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1Z14_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS02865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H1Z14_RS02880	COG0193	aminoacyl-tRNA hydrolase activity
H1Z14_RS02890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1Z14_RS02895	COG0012	GTP binding
H1Z14_RS02915	COG0386	Belongs to the glutathione peroxidase family
H1Z14_RS02930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H1Z14_RS02935	COG2857	Cytochrome c1
H1Z14_RS02935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H1Z14_RS02960	COG1132	(ABC) transporter
H1Z14_RS02970	COG1132	(ABC) transporter
H1Z14_RS02975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1Z14_RS02985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS02995	COG0408	coproporphyrinogen oxidase activity
H1Z14_RS03010	COG0617	tRNA 3'-terminal CCA addition
H1Z14_RS03025	COG0714	Associated with various cellular activities
H1Z14_RS03045	COG0454	-acetyltransferase
H1Z14_RS03065	COG0435	Glutathione S-transferase
H1Z14_RS03080	COG0740	serine-type endopeptidase activity
H1Z14_RS03085	COG3135	benzoate transporter
H1Z14_RS03090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1Z14_RS03120	COG3501	Rhs element vgr protein
H1Z14_RS03150	COG0512	Glutamine amidotransferase of anthranilate synthase
H1Z14_RS03150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1Z14_RS03160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H1Z14_RS03165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H1Z14_RS03185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1Z14_RS03200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H1Z14_RS03205	COG2197	response regulator
H1Z14_RS03220	COG1435	thymidine kinase activity
H1Z14_RS03235	COG4175	Glycine betaine
H1Z14_RS03295	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1Z14_RS03305	COG4115	mRNA cleavage
H1Z14_RS03310	COG0366	Alpha amylase catalytic
H1Z14_RS03320	COG1160	GTP binding
H1Z14_RS03340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1Z14_RS03355	COG0024	Methionine aminopeptidase
H1Z14_RS03360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS03365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1Z14_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS03380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Z14_RS03390	COG0457	Tetratricopeptide repeat
H1Z14_RS03395	COG0583	DNA-binding transcription factor activity
H1Z14_RS03405	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS03410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS03425	COG0137	argininosuccinate synthase activity
H1Z14_RS03460	COG2351	hydroxyisourate hydrolase activity
H1Z14_RS03465	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1Z14_RS03470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Z14_RS03475	COG0174	glutamine synthetase
H1Z14_RS03485	COG3648	Uricase
H1Z14_RS03485	COG3195	allantoin biosynthetic process
H1Z14_RS03490	COG1064	alcohol dehydrogenase
H1Z14_RS03505	COG3706	GGDEF domain
H1Z14_RS03520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS03525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1Z14_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS03530	COG2205	protein histidine kinase activity
H1Z14_RS03530	COG5002	protein histidine kinase activity
H1Z14_RS03530	COG0784	Response regulator, receiver
H1Z14_RS03540	COG0513	Belongs to the DEAD box helicase family
H1Z14_RS03555	COG1733	regulation of RNA biosynthetic process
H1Z14_RS03570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1Z14_RS03585	COG1982	Orn Lys Arg decarboxylase major
H1Z14_RS03650	COG3501	Rhs element vgr protein
H1Z14_RS03760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1Z14_RS03800	COG0583	DNA-binding transcription factor activity
H1Z14_RS03815	COG2308	Evidence 4 Homologs of previously reported genes of
H1Z14_RS03825	COG2346	COG2346, Truncated hemoglobins
H1Z14_RS03845	COG0493	'glutamate synthase
H1Z14_RS03865	COG1309	transcriptional regulator
H1Z14_RS03895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS03900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS03905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS03930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H1Z14_RS03935	COG0830	nickel cation binding
H1Z14_RS03940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H1Z14_RS03945	COG5001	Diguanylate cyclase
H1Z14_RS03945	COG5002	protein histidine kinase activity
H1Z14_RS03965	COG0804	urea catabolic process
H1Z14_RS03970	COG1442	glycosyl transferase family 8
H1Z14_RS03975	COG3755	Protein conserved in bacteria
H1Z14_RS03980	COG0832	Belongs to the urease beta subunit family
H1Z14_RS03985	COG3813	Protein conserved in bacteria
H1Z14_RS03990	COG0831	urea catabolic process
H1Z14_RS03995	COG0829	nickel cation binding
H1Z14_RS04040	COG4251	negative regulation of phosphorylation
H1Z14_RS04050	COG0784	Response regulator, receiver
H1Z14_RS04050	COG2205	protein histidine kinase activity
H1Z14_RS04060	COG0546	phosphoglycolate phosphatase activity
H1Z14_RS04080	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H1Z14_RS04085	COG2894	cell division
H1Z14_RS04090	COG0850	regulation of cytokinetic process
H1Z14_RS04135	COG2814	Major facilitator Superfamily
H1Z14_RS04145	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1Z14_RS04200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Z14_RS04210	COG0564	pseudouridine synthase activity
H1Z14_RS04215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS04215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1Z14_RS04220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1Z14_RS04230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H1Z14_RS04245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1Z14_RS04255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1Z14_RS04275	COG1116	anion transmembrane transporter activity
H1Z14_RS04285	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS04295	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1Z14_RS04320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H1Z14_RS04355	COG1175	transmembrane transport
H1Z14_RS04380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Z14_RS04390	COG0482	sulfurtransferase activity
H1Z14_RS04400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1Z14_RS04405	COG1122	ATPase activity
H1Z14_RS04535	COG5005	Phage virion morphogenesis
H1Z14_RS04595	COG4396	Host-nuclease inhibitor protein Gam
H1Z14_RS04650	COG4774	siderophore transport
H1Z14_RS04670	COG1120	ATPase activity
H1Z14_RS04680	COG4774	siderophore transport
H1Z14_RS04705	COG1294	oxidase, subunit
H1Z14_RS04710	COG1271	oxidase subunit
H1Z14_RS04715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Z14_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS04745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H1Z14_RS04750	COG0632	four-way junction helicase activity
H1Z14_RS04755	COG2002	toxin-antitoxin pair type II binding
H1Z14_RS04765	COG2255	four-way junction helicase activity
H1Z14_RS04770	COG1408	metallophosphoesterase
H1Z14_RS04775	COG0494	nUDIX hydrolase
H1Z14_RS04790	COG0824	Thioesterase
H1Z14_RS04810	COG0823	Involved in the tonB-independent uptake of proteins
H1Z14_RS04815	COG2885	chlorophyll binding
H1Z14_RS04825	COG0037	tRNA processing
H1Z14_RS04830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1Z14_RS04835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1Z14_RS04840	COG0217	transcriptional regulatory protein
H1Z14_RS04905	COG0840	transmembrane signaling receptor activity
H1Z14_RS04910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1Z14_RS04915	COG1692	metallophosphoesterase
H1Z14_RS04920	COG0126	phosphoglycerate kinase activity
H1Z14_RS04925	COG3588	fructose-bisphosphate aldolase
H1Z14_RS04930	COG0384	phenazine biosynthesis protein PhzF
H1Z14_RS04965	COG0254	rRNA binding
H1Z14_RS04970	COG1132	(ABC) transporter
H1Z14_RS04990	COG0483	inositol monophosphate 1-phosphatase activity
H1Z14_RS05000	COG0352	thiamine-phosphate diphosphorylase activity
H1Z14_RS05010	COG0640	Transcriptional regulator
H1Z14_RS05025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H1Z14_RS05030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1Z14_RS05035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H1Z14_RS05040	COG0457	Tetratricopeptide repeat
H1Z14_RS05045	COG0596	Alpha beta hydrolase
H1Z14_RS05050	COG0469	pyruvate kinase activity
H1Z14_RS05070	COG3750	Belongs to the UPF0335 family
H1Z14_RS05090	COG0512	Glutamine amidotransferase of anthranilate synthase
H1Z14_RS05090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1Z14_RS05095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS05105	COG5310	Homospermidine synthase
H1Z14_RS05115	COG0737	Belongs to the 5'-nucleotidase family
H1Z14_RS05120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H1Z14_RS05130	COG0840	transmembrane signaling receptor activity
H1Z14_RS05140	COG0602	queuosine metabolic process
H1Z14_RS05145	COG0720	synthase
H1Z14_RS05150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1Z14_RS05155	COG0330	HflC and HflK could
H1Z14_RS05165	COG0517	IMP dehydrogenase activity
H1Z14_RS05165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1Z14_RS05175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1Z14_RS05180	COG2951	lytic endotransglycosylase activity
H1Z14_RS05190	COG0840	transmembrane signaling receptor activity
H1Z14_RS05200	COG0070	glutamate synthase
H1Z14_RS05200	COG0067	glutamate synthase
H1Z14_RS05200	COG0069	glutamate synthase activity
H1Z14_RS05210	COG0071	Belongs to the small heat shock protein (HSP20) family
H1Z14_RS05265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H1Z14_RS05265	COG0662	Cupin 2, conserved barrel domain protein
H1Z14_RS05275	COG2308	Evidence 4 Homologs of previously reported genes of
H1Z14_RS05275	COG2307	Protein conserved in bacteria
H1Z14_RS05295	COG0058	SHG alpha-glucan phosphorylase activity
H1Z14_RS05300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Z14_RS05305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H1Z14_RS05310	COG0297	glycogen (starch) synthase activity
H1Z14_RS05315	COG0033	Phosphoglucomutase
H1Z14_RS05355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1Z14_RS05360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS05370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Z14_RS05370	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1Z14_RS05385	COG1733	regulation of RNA biosynthetic process
H1Z14_RS05390	COG3041	Addiction module toxin RelE StbE family
H1Z14_RS05395	COG3077	Addiction module antitoxin, RelB DinJ family
H1Z14_RS05425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H1Z14_RS05430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H1Z14_RS05435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Z14_RS05440	COG1609	Transcriptional regulator
H1Z14_RS05445	COG1846	Transcriptional regulator
H1Z14_RS05455	COG0523	cobalamin synthesis protein
H1Z14_RS05465	COG2972	Histidine kinase
H1Z14_RS05465	COG0840	transmembrane signaling receptor activity
H1Z14_RS05470	COG3047	cAMP biosynthetic process
H1Z14_RS05495	COG0583	DNA-binding transcription factor activity
H1Z14_RS05525	COG0800	Aldolase
H1Z14_RS05530	COG2954	triphosphatase activity
H1Z14_RS05540	COG2378	regulation of single-species biofilm formation
H1Z14_RS05555	COG2199	diguanylate cyclase activity
H1Z14_RS05555	COG2202	Pas domain
H1Z14_RS05555	COG2200	EAL domain
H1Z14_RS05575	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS05585	COG2115	Belongs to the xylose isomerase family
H1Z14_RS05590	COG1070	Carbohydrate kinase
H1Z14_RS05595	COG1609	Transcriptional regulator
H1Z14_RS05610	COG1309	transcriptional regulator
H1Z14_RS05615	COG1253	flavin adenine dinucleotide binding
H1Z14_RS05635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1Z14_RS05650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1Z14_RS05670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H1Z14_RS05675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1Z14_RS05680	COG0471	metal ion transport
H1Z14_RS05680	COG3273	potassium ion transport
H1Z14_RS05695	COG2274	protein secretion by the type I secretion system
H1Z14_RS05730	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS05735	COG1473	amidohydrolase
H1Z14_RS05750	COG0601	transmembrane transport
H1Z14_RS05755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS05760	COG0842	Transport permease protein
H1Z14_RS05765	COG1129	ABC transporter
H1Z14_RS05765	COG0842	Transport permease protein
H1Z14_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS05775	COG3191	aminopeptidase activity
H1Z14_RS05780	COG3454	Phosphonate metabolism
H1Z14_RS05790	COG0444	Belongs to the ABC transporter superfamily
H1Z14_RS05800	COG0601	transmembrane transport
H1Z14_RS05805	COG0747	negative chemotaxis
H1Z14_RS05815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS05820	COG1802	Transcriptional regulator
H1Z14_RS05825	COG1904	glucuronate isomerase
H1Z14_RS05830	COG1917	Cupin 2, conserved barrel domain protein
H1Z14_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS05845	COG0246	Mannitol dehydrogenase
H1Z14_RS05850	COG1312	Catalyzes the dehydration of D-mannonate
H1Z14_RS05855	COG2721	sulfolactate sulfo-lyase activity
H1Z14_RS05865	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H1Z14_RS05880	COG4213	ABC transporter substrate-binding protein
H1Z14_RS05890	COG4214	carbohydrate transport
H1Z14_RS05900	COG0129	dihydroxy-acid dehydratase activity
H1Z14_RS05915	COG3734	2-keto-3-deoxy-galactonokinase
H1Z14_RS05920	COG0800	Aldolase
H1Z14_RS05925	COG2832	Protein of unknown function (DUF454)
H1Z14_RS05930	COG0697	spore germination
H1Z14_RS05935	COG2186	Transcriptional regulator
H1Z14_RS05940	COG2807	transmembrane transport
H1Z14_RS05945	COG2373	Large extracellular alpha-helical protein
H1Z14_RS05950	COG4953	penicillin-binding protein 1C
H1Z14_RS05955	COG2972	Histidine kinase
H1Z14_RS05955	COG0840	transmembrane signaling receptor activity
H1Z14_RS05960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Z14_RS05965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1Z14_RS05970	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS05990	COG0747	negative chemotaxis
H1Z14_RS06010	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS06040	COG0419	ATPase involved in DNA repair
H1Z14_RS06045	COG0840	transmembrane signaling receptor activity
H1Z14_RS06090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1Z14_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS06105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Z14_RS06115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H1Z14_RS06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Z14_RS06140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1Z14_RS06170	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS06185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H1Z14_RS06195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS06210	COG1793	dna ligase
H1Z14_RS06230	COG0783	Belongs to the Dps family
H1Z14_RS06240	COG0784	Response regulator, receiver
H1Z14_RS06280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Z14_RS06295	COG0848	biopolymer transport protein
H1Z14_RS06305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Z14_RS06320	COG0010	Belongs to the arginase family
H1Z14_RS06340	COG1940	carbohydrate kinase activity
H1Z14_RS06360	COG0572	uridine kinase
H1Z14_RS06365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS06370	COG0765	amino acid transport
H1Z14_RS06375	COG0765	amino acid transport
H1Z14_RS06380	COG4598	ABC transporter
H1Z14_RS06395	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS06400	COG1228	amidohydrolase
H1Z14_RS06405	COG2986	histidine ammonia-lyase
H1Z14_RS06415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H1Z14_RS06435	COG1289	transmembrane transporter activity
H1Z14_RS06460	COG0346	lactoylglutathione lyase activity
H1Z14_RS06465	COG0400	carboxylic ester hydrolase activity
H1Z14_RS06485	COG3307	-O-antigen
H1Z14_RS06490	COG1596	polysaccharide export
H1Z14_RS06495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1Z14_RS06505	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS06510	COG2327	Polysaccharide pyruvyl transferase
H1Z14_RS06515	COG0463	Glycosyl transferase, family 2
H1Z14_RS06520	COG2244	polysaccharide biosynthetic process
H1Z14_RS06525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H1Z14_RS06530	COG2273	Hydrolase Family 16
H1Z14_RS06535	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS06540	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS06545	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS06550	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS06555	COG0489	protein tyrosine kinase activity
H1Z14_RS06555	COG3206	protein involved in exopolysaccharide biosynthesis
H1Z14_RS06560	COG0469	pyruvate kinase activity
H1Z14_RS06605	COG0542	response to heat
H1Z14_RS06615	COG2890	protein-(glutamine-N5) methyltransferase activity
H1Z14_RS06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H1Z14_RS06630	COG0527	aspartate kinase activity
H1Z14_RS06650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1Z14_RS06660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1Z14_RS06665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1Z14_RS06675	COG2226	methyltransferase
H1Z14_RS06690	COG0494	nUDIX hydrolase
H1Z14_RS06700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1Z14_RS06705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1Z14_RS06710	COG0653	protein targeting
H1Z14_RS06725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1Z14_RS06775	COG0667	Aldo Keto reductase
H1Z14_RS06820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1Z14_RS06830	COG0300	oxidoreductase activity
H1Z14_RS06845	COG2086	electron transfer activity
H1Z14_RS06855	COG0840	transmembrane signaling receptor activity
H1Z14_RS06855	COG2972	Histidine kinase
H1Z14_RS06860	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1Z14_RS06865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1Z14_RS06870	COG0165	Argininosuccinate lyase
H1Z14_RS06880	COG0019	diaminopimelate decarboxylase activity
H1Z14_RS06905	COG2884	Cell division ATP-binding protein ftsE
H1Z14_RS06925	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H1Z14_RS06935	COG0287	Prephenate dehydrogenase
H1Z14_RS06940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Z14_RS06945	COG2226	methyltransferase
H1Z14_RS06950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Z14_RS06975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H1Z14_RS06980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H1Z14_RS07010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H1Z14_RS07015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1Z14_RS07025	COG4974	Belongs to the 'phage' integrase family
H1Z14_RS07030	COG0825	malonyl-CoA metabolic process
H1Z14_RS07035	COG3034	peptidoglycan biosynthetic process
H1Z14_RS07045	COG0523	cobalamin synthesis protein
H1Z14_RS07050	COG1686	Belongs to the peptidase S11 family
H1Z14_RS07055	COG1473	amidohydrolase
H1Z14_RS07065	COG0628	permease
H1Z14_RS07075	COG2771	luxR family
H1Z14_RS07080	COG1766	The M ring may be actively involved in energy transduction
H1Z14_RS07090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H1Z14_RS07095	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS07100	COG2201	protein-glutamate methylesterase activity
H1Z14_RS07105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Z14_RS07110	COG0835	chemotaxis
H1Z14_RS07115	COG2198	Histidine kinase
H1Z14_RS07115	COG0643	Histidine kinase
H1Z14_RS07120	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS07130	COG0840	transmembrane signaling receptor activity
H1Z14_RS07140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H1Z14_RS07150	COG0156	8-amino-7-oxononanoate synthase activity
H1Z14_RS07160	COG0729	surface antigen
H1Z14_RS07175	COG0835	chemotaxis
H1Z14_RS07180	COG2223	nitrite transmembrane transporter activity
H1Z14_RS07190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1Z14_RS07195	COG3383	formate dehydrogenase (NAD+) activity
H1Z14_RS07210	COG0583	DNA-binding transcription factor activity
H1Z14_RS07215	COG0640	Transcriptional regulator
H1Z14_RS07220	COG0039	L-malate dehydrogenase activity
H1Z14_RS07225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H1Z14_RS07230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H1Z14_RS07235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H1Z14_RS07240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H1Z14_RS07245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1Z14_RS07260	COG0840	transmembrane signaling receptor activity
H1Z14_RS07260	COG2972	Histidine kinase
H1Z14_RS07270	COG4974	Belongs to the 'phage' integrase family
H1Z14_RS07295	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Z14_RS07305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H1Z14_RS07315	COG0045	succinate-CoA ligase (ADP-forming) activity
H1Z14_RS07320	COG0039	L-malate dehydrogenase activity
H1Z14_RS07325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1Z14_RS07370	COG2350	Protein conserved in bacteria
H1Z14_RS07375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H1Z14_RS07380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H1Z14_RS07385	COG0181	hydroxymethylbilane synthase activity
H1Z14_RS07425	COG1872	DUF167
H1Z14_RS07430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1Z14_RS07450	COG0339	signal peptide processing
H1Z14_RS07460	COG0137	argininosuccinate synthase activity
H1Z14_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS07475	COG1280	lysine exporter protein (LysE YggA)
H1Z14_RS07485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H1Z14_RS07500	COG2154	pterin-4-alpha-carbinolamine dehydratase
H1Z14_RS07505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H1Z14_RS07515	COG1136	(ABC) transporter
H1Z14_RS07520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1Z14_RS07525	COG0670	Belongs to the BI1 family
H1Z14_RS07545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1Z14_RS07550	COG4133	protoheme IX ABC transporter activity
H1Z14_RS07555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1Z14_RS07560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1Z14_RS07580	COG2917	probably involved in intracellular septation
H1Z14_RS07585	COG0552	protein localization to endoplasmic reticulum
H1Z14_RS07590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1Z14_RS07595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H1Z14_RS07610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1Z14_RS07615	COG1605	Chorismate mutase
H1Z14_RS07615	COG0287	Prephenate dehydrogenase
H1Z14_RS07620	COG0228	four-way junction DNA binding
H1Z14_RS07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1Z14_RS07630	COG0336	Belongs to the RNA methyltransferase TrmD family
H1Z14_RS07640	COG0335	large ribosomal subunit rRNA binding
H1Z14_RS07655	COG2372	response to copper ion
H1Z14_RS07660	COG1276	copper resistance
H1Z14_RS07660	COG2372	response to copper ion
H1Z14_RS07670	COG0765	amino acid transport
H1Z14_RS07690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H1Z14_RS07705	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS07725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1Z14_RS07730	COG1674	ftsk spoiiie
H1Z14_RS07735	COG0004	ammonium transporteR
H1Z14_RS07740	COG0347	Belongs to the P(II) protein family
H1Z14_RS07745	COG1946	Acyl-CoA thioesterase
H1Z14_RS07750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Z14_RS07755	COG2835	tetraacyldisaccharide 4'-kinase activity
H1Z14_RS07760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1Z14_RS07765	COG3118	belongs to the thioredoxin family
H1Z14_RS07785	COG2017	converts alpha-aldose to the beta-anomer
H1Z14_RS07800	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H1Z14_RS07815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1Z14_RS07855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H1Z14_RS07885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H1Z14_RS07890	COG0799	negative regulation of ribosome biogenesis
H1Z14_RS07895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H1Z14_RS07900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H1Z14_RS07905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H1Z14_RS07910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H1Z14_RS07930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H1Z14_RS07935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H1Z14_RS07955	COG0138	bifunctional purine biosynthesis protein purh
H1Z14_RS07965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Z14_RS07965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1Z14_RS07970	COG0501	Belongs to the peptidase M48B family
H1Z14_RS07990	COG0793	Belongs to the peptidase S41A family
H1Z14_RS08000	COG0494	nUDIX hydrolase
H1Z14_RS08005	COG1192	Involved in chromosome partitioning
H1Z14_RS08030	COG2201	protein-glutamate methylesterase activity
H1Z14_RS08035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Z14_RS08040	COG0835	chemotaxis
H1Z14_RS08045	COG0840	transmembrane signaling receptor activity
H1Z14_RS08050	COG3290	protein histidine kinase activity
H1Z14_RS08050	COG0840	transmembrane signaling receptor activity
H1Z14_RS08055	COG0840	transmembrane signaling receptor activity
H1Z14_RS08060	COG0835	chemotaxis
H1Z14_RS08065	COG0643	Histidine kinase
H1Z14_RS08065	COG2198	Histidine kinase
H1Z14_RS08070	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS08095	COG1522	sequence-specific DNA binding
H1Z14_RS08110	COG4221	oxidoreductase activity
H1Z14_RS08125	COG0738	Major facilitator superfamily
H1Z14_RS08130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H1Z14_RS08135	COG2885	chlorophyll binding
H1Z14_RS08145	COG0142	geranyltranstransferase activity
H1Z14_RS08150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1Z14_RS08160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H1Z14_RS08165	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H1Z14_RS08170	COG0183	Belongs to the thiolase family
H1Z14_RS08200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1Z14_RS08220	COG2301	Belongs to the HpcH HpaI aldolase family
H1Z14_RS08230	COG0066	3-isopropylmalate dehydratase activity
H1Z14_RS08235	COG0473	3-isopropylmalate dehydrogenase activity
H1Z14_RS08240	COG0671	phosphoesterase, PA-phosphatase related
H1Z14_RS08255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1Z14_RS08265	COG2010	Cytochrome c
H1Z14_RS08270	COG0288	reversible hydration of carbon dioxide
H1Z14_RS08275	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H1Z14_RS08280	COG2902	Dehydrogenase
H1Z14_RS08290	COG3459	Glycosyltransferase 36 associated
H1Z14_RS08295	COG1473	amidohydrolase
H1Z14_RS08310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H1Z14_RS08320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1Z14_RS08330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H1Z14_RS08335	COG0495	leucyl-tRNA aminoacylation
H1Z14_RS08360	COG0357	Ribosomal RNA small subunit methyltransferase G
H1Z14_RS08365	COG0445	tRNA wobble uridine modification
H1Z14_RS08370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H1Z14_RS08375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H1Z14_RS08385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H1Z14_RS08390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H1Z14_RS08395	COG0424	maF-like protein
H1Z14_RS08400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1Z14_RS08405	COG0237	dephospho-CoA kinase activity
H1Z14_RS08415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H1Z14_RS08430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H1Z14_RS08470	COG0135	phosphoribosylanthranilate isomerase activity
H1Z14_RS08475	COG0133	tryptophan synthase activity
H1Z14_RS08480	COG0159	tryptophan synthase activity
H1Z14_RS08485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H1Z14_RS08490	COG0285	dihydrofolate synthase activity
H1Z14_RS08515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H1Z14_RS08520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H1Z14_RS08525	COG0131	Imidazoleglycerol-phosphate dehydratase
H1Z14_RS08530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1Z14_RS08535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H1Z14_RS08540	COG0107	imidazoleglycerol-phosphate synthase activity
H1Z14_RS08545	COG0140	phosphoribosyl-ATP diphosphatase activity
H1Z14_RS08550	COG1072	(Pantothenic acid kinase))
H1Z14_RS08565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H1Z14_RS08570	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS08575	COG0642	Histidine kinase
H1Z14_RS08585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1Z14_RS08585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Z14_RS08590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Z14_RS08595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1Z14_RS08600	COG2205	protein histidine kinase activity
H1Z14_RS08605	COG3178	'Phosphotransferase
H1Z14_RS08610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1Z14_RS08615	COG2887	Belongs to the helicase family. UvrD subfamily
H1Z14_RS08620	COG1074	ATP-dependent DNA helicase activity
H1Z14_RS08625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1Z14_RS08640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H1Z14_RS08650	COG1643	Atp-dependent helicase
H1Z14_RS08655	COG2423	ornithine cyclodeaminase activity
H1Z14_RS08700	COG2814	Major facilitator Superfamily
H1Z14_RS08705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS08710	COG1609	Transcriptional regulator
H1Z14_RS08720	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS08730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS08735	COG3962	Belongs to the TPP enzyme family
H1Z14_RS08750	COG3718	enzyme involved in inositol metabolism
H1Z14_RS08775	COG4221	oxidoreductase activity
H1Z14_RS08780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Z14_RS08795	COG1595	DNA-templated transcription, initiation
H1Z14_RS08800	COG3806	Anti-sigma factor
H1Z14_RS08820	COG3842	ATPase activity
H1Z14_RS08825	COG3842	ATPase activity
H1Z14_RS08835	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS08850	COG3474	cytochrome
H1Z14_RS08855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H1Z14_RS08860	COG0077	Prephenate dehydratase
H1Z14_RS08860	COG1605	Chorismate mutase
H1Z14_RS08870	COG2816	NAD+ diphosphatase activity
H1Z14_RS08885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1Z14_RS08890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H1Z14_RS08900	COG3422	double-strand break repair
H1Z14_RS08915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1Z14_RS08920	COG0481	GTPase activity
H1Z14_RS08935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1Z14_RS08940	COG1607	acyl-coa hydrolase
H1Z14_RS08965	COG1393	Belongs to the ArsC family
H1Z14_RS08970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1Z14_RS08975	COG2309	aminopeptidase activity
H1Z14_RS08990	COG1278	Cold shock
H1Z14_RS08995	COG1570	exodeoxyribonuclease VII activity
H1Z14_RS09035	COG0667	Aldo Keto reductase
H1Z14_RS09050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1Z14_RS09055	COG2951	lytic endotransglycosylase activity
H1Z14_RS09080	COG2814	Major facilitator Superfamily
H1Z14_RS09090	COG0779	Required for maturation of 30S ribosomal subunits
H1Z14_RS09095	COG0195	Participates in both transcription termination and antitermination
H1Z14_RS09095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1Z14_RS09105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H1Z14_RS09110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H1Z14_RS09115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1Z14_RS09120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H1Z14_RS09125	COG1185	polyribonucleotide nucleotidyltransferase activity
H1Z14_RS09130	COG2813	Specifically methylates the guanine in position
H1Z14_RS09135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1Z14_RS09145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Z14_RS09155	COG2860	membrane
H1Z14_RS09165	COG0477	Major facilitator Superfamily
H1Z14_RS09180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H1Z14_RS09185	COG0539	negative regulation of cytoplasmic translation
H1Z14_RS09205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H1Z14_RS09210	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS09215	COG2205	protein histidine kinase activity
H1Z14_RS09220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H1Z14_RS09225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H1Z14_RS09230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H1Z14_RS09240	COG0072	phenylalanine-tRNA ligase activity
H1Z14_RS09240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Z14_RS09285	COG4964	Belongs to the GSP D family
H1Z14_RS09325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H1Z14_RS09330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1Z14_RS09335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H1Z14_RS09345	COG0588	phosphoglycerate mutase activity
H1Z14_RS09350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H1Z14_RS09355	COG1132	(ABC) transporter
H1Z14_RS09360	COG0837	glucose binding
H1Z14_RS09365	COG1803	Methylglyoxal synthase
H1Z14_RS09370	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H1Z14_RS09375	COG4166	transmembrane transport
H1Z14_RS09380	COG4174	ABC transporter (Permease)
H1Z14_RS09385	COG4239	(ABC) transporter, permease
H1Z14_RS09390	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS09395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Z14_RS09405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H1Z14_RS09460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H1Z14_RS09465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H1Z14_RS09470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H1Z14_RS09475	COG2188	Transcriptional regulator
H1Z14_RS09480	COG3624	Phosphonate C-P lyase system protein PhnG
H1Z14_RS09485	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H1Z14_RS09490	COG3626	phosphonate metabolism
H1Z14_RS09495	COG3627	carbon phosphorus lyase activity
H1Z14_RS09500	COG4107	phosphonate C-P lyase system protein PhnK
H1Z14_RS09505	COG4778	phosphonate C-P lyase system protein PhnL
H1Z14_RS09515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H1Z14_RS09520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H1Z14_RS09530	COG3639	organic phosphonate transmembrane transporter activity
H1Z14_RS09535	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1Z14_RS09540	COG3454	Phosphonate metabolism
H1Z14_RS09545	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H1Z14_RS09560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1Z14_RS09565	COG2353	YceI-like domain
H1Z14_RS09570	COG2353	YceI-like domain
H1Z14_RS09580	COG0791	NLP P60 protein
H1Z14_RS09585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1Z14_RS09585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1Z14_RS09595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS09605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1Z14_RS09620	COG0443	Heat shock 70 kDa protein
H1Z14_RS09630	COG0484	heat shock protein binding
H1Z14_RS09635	COG2900	Belongs to the SlyX family
H1Z14_RS09640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1Z14_RS09655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Z14_RS09665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS09670	COG5001	Diguanylate cyclase
H1Z14_RS09675	COG3002	Belongs to the UPF0753 family
H1Z14_RS09680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1Z14_RS09705	COG0519	Catalyzes the synthesis of GMP from XMP
H1Z14_RS09705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1Z14_RS09720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H1Z14_RS09745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H1Z14_RS09745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Z14_RS09750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1Z14_RS09760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1Z14_RS09770	COG1968	undecaprenyl-diphosphatase activity
H1Z14_RS09790	COG0284	orotidine-5'-phosphate decarboxylase activity
H1Z14_RS09800	COG3963	phosphatidate phosphatase activity
H1Z14_RS09810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1Z14_RS09815	COG0792	nuclease activity
H1Z14_RS09820	COG1653	transport
H1Z14_RS09825	COG1175	transmembrane transport
H1Z14_RS09830	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS09835	COG3842	ATPase activity
H1Z14_RS09845	COG0189	ligase activity
H1Z14_RS09850	COG0606	chelatase, subunit chli
H1Z14_RS09865	COG1280	lysine exporter protein (LysE YggA)
H1Z14_RS09870	COG0756	dUTP diphosphatase activity
H1Z14_RS09875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1Z14_RS09880	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1Z14_RS09885	COG1877	trehalose-phosphatase activity
H1Z14_RS09905	COG1741	Belongs to the pirin family
H1Z14_RS09915	COG0583	DNA-binding transcription factor activity
H1Z14_RS09930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1Z14_RS09935	COG3920	Histidine kinase
H1Z14_RS09940	COG0784	Response regulator, receiver
H1Z14_RS09945	COG0784	Response regulator, receiver
H1Z14_RS09945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS09945	COG2198	Histidine kinase
H1Z14_RS09945	COG2205	protein histidine kinase activity
H1Z14_RS09950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1Z14_RS09955	COG2226	methyltransferase
H1Z14_RS09960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H1Z14_RS09965	COG0268	Binds directly to 16S ribosomal RNA
H1Z14_RS09975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H1Z14_RS09980	COG0697	spore germination
H1Z14_RS09985	COG2226	methyltransferase
H1Z14_RS09990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1Z14_RS09995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H1Z14_RS10005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H1Z14_RS10010	COG1420	regulation of RNA biosynthetic process
H1Z14_RS10015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H1Z14_RS10020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1Z14_RS10025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H1Z14_RS10035	COG1137	ATPase activity
H1Z14_RS10040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1Z14_RS10050	COG0776	regulation of translation
H1Z14_RS10060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H1Z14_RS10060	COG0116	Belongs to the methyltransferase superfamily
H1Z14_RS10065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Z14_RS10070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H1Z14_RS10085	COG0583	DNA-binding transcription factor activity
H1Z14_RS10090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1Z14_RS10095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H1Z14_RS10105	COG0346	lactoylglutathione lyase activity
H1Z14_RS10110	COG0180	Tryptophanyl-tRNA synthetase
H1Z14_RS10120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H1Z14_RS10125	COG1214	PFAM Peptidase M22, glycoprotease
H1Z14_RS10145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1Z14_RS10150	COG1702	phosphate starvation-inducible protein PhoH
H1Z14_RS10155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H1Z14_RS10160	COG4535	Mg2 and Co2 transporter CorC
H1Z14_RS10165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H1Z14_RS10170	COG1396	sequence-specific DNA binding
H1Z14_RS10175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H1Z14_RS10180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1Z14_RS10190	COG0071	Belongs to the small heat shock protein (HSP20) family
H1Z14_RS10210	COG0840	transmembrane signaling receptor activity
H1Z14_RS10220	COG2205	protein histidine kinase activity
H1Z14_RS10225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H1Z14_RS10230	COG0594	ribonuclease P activity
H1Z14_RS10235	COG0706	membrane insertase activity
H1Z14_RS10240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H1Z14_RS10245	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H1Z14_RS10260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H1Z14_RS10265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS10280	COG1749	Flagellar hook protein flgE
H1Z14_RS10290	COG2171	N-acyltransferase activity
H1Z14_RS10295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS10320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H1Z14_RS10325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1Z14_RS10335	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS10340	COG0704	Plays a role in the regulation of phosphate uptake
H1Z14_RS10345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1Z14_RS10355	COG0573	inorganic phosphate transmembrane transporter activity
H1Z14_RS10365	COG5002	protein histidine kinase activity
H1Z14_RS10370	COG2326	polyphosphate kinase activity
H1Z14_RS10410	COG2188	Transcriptional regulator
H1Z14_RS10415	COG2986	histidine ammonia-lyase
H1Z14_RS10435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H1Z14_RS10440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H1Z14_RS10450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H1Z14_RS10470	COG0427	acetyl-CoA hydrolase
H1Z14_RS10480	COG3938	Belongs to the proline racemase family
H1Z14_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Z14_RS10490	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS10510	COG0418	dihydroorotase activity
H1Z14_RS10515	COG3706	GGDEF domain
H1Z14_RS10520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1Z14_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS10535	COG0166	Belongs to the GPI family
H1Z14_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
H1Z14_RS10565	COG0101	tRNA pseudouridine synthase activity
H1Z14_RS10570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1Z14_RS10575	COG0242	peptide deformylase activity
H1Z14_RS10580	COG2967	ApaG domain
H1Z14_RS10590	COG0717	Belongs to the dCTP deaminase family
H1Z14_RS10620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS10645	COG0167	dihydroorotate dehydrogenase activity
H1Z14_RS10665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1Z14_RS10685	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1Z14_RS10685	COG1024	Enoyl-CoA hydratase
H1Z14_RS10690	COG0183	Belongs to the thiolase family
H1Z14_RS10695	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS10715	COG1785	Belongs to the alkaline phosphatase family
H1Z14_RS10725	COG1136	(ABC) transporter
H1Z14_RS10740	COG4251	negative regulation of phosphorylation
H1Z14_RS10740	COG2203	Gaf domain
H1Z14_RS10740	COG5001	Diguanylate cyclase
H1Z14_RS10740	COG3706	GGDEF domain
H1Z14_RS10745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H1Z14_RS10755	COG1201	RNA secondary structure unwinding
H1Z14_RS10775	COG1047	Peptidyl-prolyl cis-trans
H1Z14_RS10780	COG0784	Response regulator, receiver
H1Z14_RS10780	COG2198	Histidine kinase
H1Z14_RS10780	COG2205	protein histidine kinase activity
H1Z14_RS10785	COG1970	mechanosensitive ion channel activity
H1Z14_RS10790	COG0436	Aminotransferase
H1Z14_RS10795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1Z14_RS10815	COG1216	Glycosyl transferase, family 2
H1Z14_RS10840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1Z14_RS10845	COG0424	maF-like protein
H1Z14_RS10850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H1Z14_RS10860	COG5328	Belongs to the UPF0262 family
H1Z14_RS10865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1Z14_RS10875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1Z14_RS10905	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS10915	COG0488	(ABC) transporter
H1Z14_RS10940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1Z14_RS10945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Z14_RS10950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Z14_RS10955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H1Z14_RS10960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H1Z14_RS10965	COG4786	Flagellar basal body rod
H1Z14_RS10970	COG1157	protein secretion by the type III secretion system
H1Z14_RS10980	COG1815	bacterial-type flagellum-dependent cell motility
H1Z14_RS10985	COG1558	bacterial-type flagellum-dependent cell motility
H1Z14_RS10990	COG1677	Flagellar hook-basal body complex protein FliE
H1Z14_RS10995	COG4786	Flagellar basal body rod
H1Z14_RS11000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H1Z14_RS11005	COG1706	bacterial-type flagellum-dependent cell motility
H1Z14_RS11015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H1Z14_RS11025	COG1338	Plays a role in the flagellum-specific transport system
H1Z14_RS11030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS11035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS11040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS11045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS11050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS11060	COG1360	Flagellar Motor Protein
H1Z14_RS11085	COG1749	Flagellar hook protein flgE
H1Z14_RS11105	COG5443	negative regulation of bacterial-type flagellum assembly
H1Z14_RS11110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H1Z14_RS11115	COG4794	Type iii secretion
H1Z14_RS11120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H1Z14_RS11155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H1Z14_RS11160	COG1609	Transcriptional regulator
H1Z14_RS11165	COG1653	transport
H1Z14_RS11170	COG1175	transmembrane transport
H1Z14_RS11175	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS11180	COG0366	Alpha amylase catalytic
H1Z14_RS11185	COG3842	ATPase activity
H1Z14_RS11200	COG3493	citrate carrier protein
H1Z14_RS11220	COG0129	dihydroxy-acid dehydratase activity
H1Z14_RS11225	COG0363	glucosamine-6-phosphate deaminase activity
H1Z14_RS11230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H1Z14_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS11245	COG2081	HI0933 family
H1Z14_RS11260	COG2972	Histidine kinase
H1Z14_RS11260	COG0840	transmembrane signaling receptor activity
H1Z14_RS11265	COG0583	DNA-binding transcription factor activity
H1Z14_RS11290	COG2224	Isocitrate lyase
H1Z14_RS11305	COG3842	ATPase activity
H1Z14_RS11310	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS11315	COG1177	transmembrane transport
H1Z14_RS11325	COG2205	protein histidine kinase activity
H1Z14_RS11380	COG1959	2 iron, 2 sulfur cluster binding
H1Z14_RS11385	COG3265	gluconokinase activity
H1Z14_RS11390	COG2134	cdp-diacylglycerol pyrophosphatase
H1Z14_RS11395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS11400	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Z14_RS11420	COG0579	oxidoreductase
H1Z14_RS11440	COG0248	Ppx GppA phosphatase
H1Z14_RS11445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H1Z14_RS11455	COG5001	Diguanylate cyclase
H1Z14_RS11455	COG3300	MHYT domain
H1Z14_RS11460	COG2198	Histidine kinase
H1Z14_RS11460	COG0784	Response regulator, receiver
H1Z14_RS11460	COG5002	protein histidine kinase activity
H1Z14_RS11465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1Z14_RS11475	COG1663	tetraacyldisaccharide 4'-kinase activity
H1Z14_RS11485	COG1519	Transferase
H1Z14_RS11495	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1Z14_RS11500	COG0312	modulator of DNA gyrase
H1Z14_RS11505	COG0475	glutathione-regulated potassium exporter activity
H1Z14_RS11505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1Z14_RS11515	COG0742	ribosomal rna small subunit methyltransferase
H1Z14_RS11520	COG1187	pseudouridine synthase activity
H1Z14_RS11525	COG0590	tRNA wobble adenosine to inosine editing
H1Z14_RS11535	COG0477	Major facilitator Superfamily
H1Z14_RS11545	COG3386	PFAM SMP-30 Gluconolaconase
H1Z14_RS11550	COG2771	luxR family
H1Z14_RS11570	COG0598	Magnesium transport protein CorA
H1Z14_RS11575	COG3158	transport of potassium into the cell
H1Z14_RS11585	COG0356	it plays a direct role in the translocation of protons across the membrane
H1Z14_RS11595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1Z14_RS11600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1Z14_RS11605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1Z14_RS11620	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1Z14_RS11625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H1Z14_RS11635	COG0142	geranyltranstransferase activity
H1Z14_RS11645	COG4106	trans-aconitate 2-methyltransferase activity
H1Z14_RS11665	COG0752	glycyl-tRNA synthetase alpha subunit
H1Z14_RS11675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1Z14_RS11680	COG0751	glycine-tRNA ligase activity
H1Z14_RS11685	COG1683	Conserved Protein
H1Z14_RS11690	COG0840	transmembrane signaling receptor activity
H1Z14_RS11690	COG0840	transmembrane signaling receptor activity
H1Z14_RS11700	COG0151	Belongs to the GarS family
H1Z14_RS11710	COG2183	response to ionizing radiation
H1Z14_RS11715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Z14_RS11720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1Z14_RS11745	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1Z14_RS11750	COG4149	molybdate abc transporter
H1Z14_RS11755	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1Z14_RS11770	COG0009	L-threonylcarbamoyladenylate synthase
H1Z14_RS11790	COG1136	(ABC) transporter
H1Z14_RS11805	COG0840	transmembrane signaling receptor activity
H1Z14_RS11805	COG2972	Histidine kinase
H1Z14_RS11815	COG4638	Rieske (2fe-2S)
H1Z14_RS11840	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS11845	COG1024	Enoyl-CoA hydratase
H1Z14_RS11860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H1Z14_RS11865	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H1Z14_RS11870	COG0840	transmembrane signaling receptor activity
H1Z14_RS11875	COG0840	transmembrane signaling receptor activity
H1Z14_RS11880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H1Z14_RS11885	COG1722	exodeoxyribonuclease VII activity
H1Z14_RS11890	COG0123	including yeast histone deacetylase and acetoin utilization protein
H1Z14_RS11900	COG1268	BioY protein
H1Z14_RS11905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H1Z14_RS11910	COG1122	ATPase activity
H1Z14_RS11920	COG3214	Protein conserved in bacteria
H1Z14_RS11940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1Z14_RS11940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1Z14_RS11945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H1Z14_RS11950	COG3300	MHYT domain
H1Z14_RS11950	COG5001	Diguanylate cyclase
H1Z14_RS11965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1Z14_RS11970	COG0484	heat shock protein binding
H1Z14_RS11980	COG0259	pyridoxamine-phosphate oxidase activity
H1Z14_RS11990	COG2814	Major facilitator Superfamily
H1Z14_RS11995	COG0789	Transcriptional regulator
H1Z14_RS12000	COG1686	Belongs to the peptidase S11 family
H1Z14_RS12015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Z14_RS12025	COG0312	modulator of DNA gyrase
H1Z14_RS12040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1Z14_RS12045	COG0109	protoheme IX farnesyltransferase activity
H1Z14_RS12055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H1Z14_RS12070	COG3346	SURF1 family
H1Z14_RS12080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H1Z14_RS12090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1Z14_RS12095	COG0328	RNA-DNA hybrid ribonuclease activity
H1Z14_RS12105	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1Z14_RS12120	COG0678	peroxiredoxin activity
H1Z14_RS12120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1Z14_RS12130	COG1678	Uncharacterized ACR, COG1678
H1Z14_RS12140	COG0640	Transcriptional regulator
H1Z14_RS12145	COG5001	Diguanylate cyclase
H1Z14_RS12150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Z14_RS12155	COG0612	Peptidase, M16
H1Z14_RS12170	COG1597	lipid kinase activity
H1Z14_RS12175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1Z14_RS12190	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H1Z14_RS12220	COG1194	a g-specific adenine glycosylase
H1Z14_RS12235	COG1196	nuclear chromosome segregation
H1Z14_RS12255	COG2814	Major facilitator Superfamily
H1Z14_RS12270	COG0574	Belongs to the PEP-utilizing enzyme family
H1Z14_RS12270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1Z14_RS12305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS12325	COG0840	transmembrane signaling receptor activity
H1Z14_RS12330	COG0175	sulfate reduction
H1Z14_RS12335	COG0175	sulfate reduction
H1Z14_RS12340	COG2895	sulfate adenylyltransferase (ATP) activity
H1Z14_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS12350	COG1309	transcriptional regulator
H1Z14_RS12355	COG1609	Transcriptional regulator
H1Z14_RS12365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Z14_RS12375	COG0693	protein deglycase activity
H1Z14_RS12395	COG0038	chloride channel
H1Z14_RS12400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H1Z14_RS12425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1Z14_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS12435	COG0625	glutathione transferase activity
H1Z14_RS12440	COG3119	arylsulfatase activity
H1Z14_RS12445	COG1309	transcriptional regulator
H1Z14_RS12450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H1Z14_RS12465	COG0840	transmembrane signaling receptor activity
H1Z14_RS12470	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
H1Z14_RS12490	COG1349	DNA-binding transcription factor activity
H1Z14_RS12540	COG0477	Major facilitator Superfamily
H1Z14_RS12550	COG0778	Nitroreductase
H1Z14_RS12570	COG1376	ErfK ybiS ycfS ynhG family protein
H1Z14_RS12570	COG1388	LysM domain
H1Z14_RS12575	COG1376	ErfK ybiS ycfS ynhG family protein
H1Z14_RS12580	COG1846	Transcriptional regulator
H1Z14_RS12585	COG1764	response to oxidative stress
H1Z14_RS12600	COG4191	Histidine kinase
H1Z14_RS12600	COG0784	Response regulator, receiver
H1Z14_RS12605	COG3265	gluconokinase activity
H1Z14_RS12615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1Z14_RS12620	COG0840	transmembrane signaling receptor activity
H1Z14_RS12625	COG0840	transmembrane signaling receptor activity
H1Z14_RS12635	COG0433	COG0433 Predicted ATPase
H1Z14_RS12655	COG0840	transmembrane signaling receptor activity
H1Z14_RS12660	COG1968	undecaprenyl-diphosphatase activity
H1Z14_RS12670	COG4214	carbohydrate transport
H1Z14_RS12675	COG4213	ABC transporter substrate-binding protein
H1Z14_RS12680	COG1940	carbohydrate kinase activity
H1Z14_RS12680	COG1846	Transcriptional regulator
H1Z14_RS12700	COG1120	ATPase activity
H1Z14_RS12705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS12720	COG2226	methyltransferase
H1Z14_RS12750	COG2010	Cytochrome c
H1Z14_RS12765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Z14_RS12775	COG1733	regulation of RNA biosynthetic process
H1Z14_RS12785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1Z14_RS12800	COG3447	MASE1 domain protein
H1Z14_RS12800	COG5001	Diguanylate cyclase
H1Z14_RS12800	COG5002	protein histidine kinase activity
H1Z14_RS12805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS12845	COG2514	catechol 2,3-dioxygenase activity
H1Z14_RS12860	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H1Z14_RS12865	COG1272	protein, Hemolysin III
H1Z14_RS12870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Z14_RS12890	COG4957	zinc ion binding
H1Z14_RS12895	COG1320	monovalent cation:proton antiporter activity
H1Z14_RS12900	COG2212	antiporter activity
H1Z14_RS12905	COG1863	multisubunit Na H antiporter MnhE subunit
H1Z14_RS12915	COG1006	Multisubunit Na H antiporter MnhC subunit
H1Z14_RS12920	COG2111	Na H antiporter
H1Z14_RS12930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1Z14_RS12955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS12960	COG1136	(ABC) transporter
H1Z14_RS12960	COG0577	efflux transmembrane transporter activity
H1Z14_RS12985	COG2166	iron-sulfur cluster assembly
H1Z14_RS12995	COG2205	protein histidine kinase activity
H1Z14_RS13010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Z14_RS13065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1Z14_RS13070	COG2983	Belongs to the UPF0260 family
H1Z14_RS13085	COG0789	Transcriptional regulator
H1Z14_RS13110	COG4695	Portal protein
H1Z14_RS13205	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS13210	COG2205	protein histidine kinase activity
H1Z14_RS13215	COG4520	surface antigen
H1Z14_RS13220	COG4235	cytochrome complex assembly
H1Z14_RS13225	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H1Z14_RS13230	COG1138	Cytochrome C-type biogenesis protein
H1Z14_RS13235	COG3088	subunit of a heme lyase
H1Z14_RS13245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1Z14_RS13250	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS13255	COG2205	protein histidine kinase activity
H1Z14_RS13260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1Z14_RS13265	COG2205	protein histidine kinase activity
H1Z14_RS13265	COG2202	Pas domain
H1Z14_RS13270	COG0308	aminopeptidase N
H1Z14_RS13275	COG3290	protein histidine kinase activity
H1Z14_RS13275	COG0840	transmembrane signaling receptor activity
H1Z14_RS13310	COG0443	Heat shock 70 kDa protein
H1Z14_RS13325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS13340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS13345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Z14_RS13350	COG2239	Acts as a magnesium transporter
H1Z14_RS13355	COG2814	Major facilitator Superfamily
H1Z14_RS13370	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS13380	COG0601	transmembrane transport
H1Z14_RS13385	COG4166	transmembrane transport
H1Z14_RS13390	COG0174	glutamine synthetase
H1Z14_RS13405	COG1695	Transcriptional regulator
H1Z14_RS13410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H1Z14_RS13415	COG0463	Glycosyl transferase, family 2
H1Z14_RS13425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1Z14_RS13435	COG0625	glutathione transferase activity
H1Z14_RS13450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1Z14_RS13490	COG0741	lytic transglycosylase activity
H1Z14_RS13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS13500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H1Z14_RS13510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1Z14_RS13510	COG2169	Transcriptional regulator
H1Z14_RS13515	COG0840	transmembrane signaling receptor activity
H1Z14_RS13525	COG1758	RNA polymerase activity
H1Z14_RS13540	COG0681	Belongs to the peptidase S26 family
H1Z14_RS13545	COG0571	ribonuclease III activity
H1Z14_RS13550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1Z14_RS13555	COG3180	Ammonia monooxygenase
H1Z14_RS13560	COG1381	Involved in DNA repair and RecF pathway recombination
H1Z14_RS13575	COG1418	mRNA catabolic process
H1Z14_RS13590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H1Z14_RS13595	COG0354	folic acid binding
H1Z14_RS13615	COG1051	belongs to the nudix hydrolase family
H1Z14_RS13630	COG1183	phosphatidylcholine synthase activity
H1Z14_RS13635	COG0688	phosphatidylethanolamine metabolic process
H1Z14_RS13640	COG5265	(ABC) transporter
H1Z14_RS13645	COG1652	LysM domain
H1Z14_RS13645	COG2823	Periplasmic or secreted lipoprotein
H1Z14_RS13655	COG2962	Rard protein
H1Z14_RS13660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1Z14_RS13700	COG0215	cysteine-tRNA ligase activity
H1Z14_RS13705	COG5434	Belongs to the glycosyl hydrolase 28 family
H1Z14_RS13710	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H1Z14_RS13715	COG1088	dTDP-glucose 4,6-dehydratase activity
H1Z14_RS13720	COG1091	dTDP-4-dehydrorhamnose reductase activity
H1Z14_RS13725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1Z14_RS13740	COG4221	oxidoreductase activity
H1Z14_RS13745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1Z14_RS13750	COG1286	toxin biosynthetic process
H1Z14_RS13755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H1Z14_RS13760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1Z14_RS13775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Z14_RS13780	COG1917	Cupin 2, conserved barrel domain protein
H1Z14_RS13780	COG2207	Transcriptional regulator
H1Z14_RS13785	COG0765	amino acid transport
H1Z14_RS13790	COG0765	amino acid transport
H1Z14_RS13800	COG0305	Participates in initiation and elongation during chromosome replication
H1Z14_RS13805	COG0359	binds to the 23S rRNA
H1Z14_RS13815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H1Z14_RS13820	COG0360	Binds together with S18 to 16S ribosomal RNA
H1Z14_RS13840	COG0667	Aldo Keto reductase
H1Z14_RS13845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1Z14_RS13855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Z14_RS13860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Z14_RS13865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1Z14_RS13870	COG1561	YicC-like family, N-terminal region
H1Z14_RS13875	COG0194	GDP metabolic process
H1Z14_RS13880	COG0500	methyltransferase
H1Z14_RS13885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1Z14_RS13890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1Z14_RS13900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H1Z14_RS13915	COG0671	phosphoesterase, PA-phosphatase related
H1Z14_RS13920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H1Z14_RS13935	COG1505	serine-type exopeptidase activity
H1Z14_RS13940	COG0488	(ABC) transporter
H1Z14_RS13950	COG0105	UTP biosynthetic process
H1Z14_RS13955	COG0314	molybdopterin synthase activity
H1Z14_RS13965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1Z14_RS13970	COG0322	excinuclease ABC activity
H1Z14_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS13985	COG0625	glutathione transferase activity
H1Z14_RS13990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1Z14_RS13995	COG0243	molybdopterin cofactor binding
H1Z14_RS14000	COG0494	nUDIX hydrolase
H1Z14_RS14005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1Z14_RS14005	COG3453	Protein conserved in bacteria
H1Z14_RS14010	COG0640	Transcriptional regulator
H1Z14_RS14025	COG0730	response to heat
H1Z14_RS14030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1Z14_RS14035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H1Z14_RS14040	COG0628	permease
H1Z14_RS14050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H1Z14_RS14055	COG0248	Ppx GppA phosphatase
H1Z14_RS14060	COG1321	iron dependent repressor
H1Z14_RS14065	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Z14_RS14085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H1Z14_RS14090	COG2132	Multicopper oxidase
H1Z14_RS14100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H1Z14_RS14115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1Z14_RS14120	COG3300	MHYT domain
H1Z14_RS14120	COG5001	Diguanylate cyclase
H1Z14_RS14130	COG2200	EAL domain
H1Z14_RS14130	COG2199	diguanylate cyclase activity
H1Z14_RS14130	COG2203	Gaf domain
H1Z14_RS14135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H1Z14_RS14150	COG0113	porphobilinogen synthase activity
H1Z14_RS14170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H1Z14_RS14175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H1Z14_RS14180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Z14_RS14180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1Z14_RS14200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H1Z14_RS14205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1Z14_RS14210	COG2814	Major facilitator Superfamily
H1Z14_RS14215	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H1Z14_RS14235	COG0416	fatty acid biosynthetic process
H1Z14_RS14240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1Z14_RS14245	COG0776	regulation of translation
H1Z14_RS14325	COG1612	heme a metabolic process
H1Z14_RS14330	COG3384	dioxygenase
H1Z14_RS14340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H1Z14_RS14345	COG0010	Belongs to the arginase family
H1Z14_RS14360	COG2329	Antibiotic biosynthesis monooxygenase
H1Z14_RS14365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1Z14_RS14370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H1Z14_RS14375	COG1832	CoA-binding protein
H1Z14_RS14385	COG1832	CoA-binding protein
H1Z14_RS14395	COG1408	metallophosphoesterase
H1Z14_RS14405	COG2124	cytochrome p450
H1Z14_RS14415	COG0740	serine-type endopeptidase activity
H1Z14_RS14420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H1Z14_RS14425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1Z14_RS14455	COG1024	Enoyl-CoA hydratase
H1Z14_RS14475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Z14_RS14480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Z14_RS14485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Z14_RS14490	COG0649	NAD binding
H1Z14_RS14500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H1Z14_RS14505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1Z14_RS14510	COG0052	Belongs to the universal ribosomal protein uS2 family
H1Z14_RS14520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H1Z14_RS14525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1Z14_RS14535	COG0713	ATP synthesis coupled electron transport
H1Z14_RS14550	COG1007	ATP synthesis coupled electron transport
H1Z14_RS14565	COG0346	lactoylglutathione lyase activity
H1Z14_RS14570	COG0251	oxidation-reduction process
H1Z14_RS14585	COG0442	prolyl-tRNA aminoacylation
H1Z14_RS14595	COG1136	(ABC) transporter
H1Z14_RS14610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1Z14_RS14625	COG0784	Response regulator, receiver
H1Z14_RS14635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H1Z14_RS14640	COG0477	Major facilitator Superfamily
H1Z14_RS14650	COG0557	exoribonuclease II activity
H1Z14_RS14655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1Z14_RS14665	COG0758	DNA mediated transformation
H1Z14_RS14670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H1Z14_RS14680	COG0540	Belongs to the ATCase OTCase family
H1Z14_RS14685	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS14705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1Z14_RS14710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1Z14_RS14715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1Z14_RS14720	COG0154	amidase activity
H1Z14_RS14735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H1Z14_RS14740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1Z14_RS14740	COG3952	Lipid A Biosynthesis
H1Z14_RS14745	COG0463	Glycosyl transferase, family 2
H1Z14_RS14750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1Z14_RS14770	COG4765	Protein conserved in bacteria
H1Z14_RS14775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1Z14_RS14785	COG0511	ligase activity, forming carbon-carbon bonds
H1Z14_RS14790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1Z14_RS14795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1Z14_RS14800	COG0436	Aminotransferase
H1Z14_RS14810	COG1530	ribonuclease E activity
H1Z14_RS14810	COG1530	ribonuclease E activity
H1Z14_RS14815	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1Z14_RS14820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1Z14_RS14830	COG0284	orotidine-5'-phosphate decarboxylase activity
H1Z14_RS14840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1Z14_RS14860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1Z14_RS14875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1Z14_RS14900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H1Z14_RS14910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H1Z14_RS14915	COG0081	regulation of translation
H1Z14_RS14920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H1Z14_RS14925	COG0222	ribosome binding
H1Z14_RS14930	COG0085	RNA polymerase activity
H1Z14_RS14935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H1Z14_RS14950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H1Z14_RS14955	COG0049	tRNA binding
H1Z14_RS14960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1Z14_RS14965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H1Z14_RS14970	COG0051	transcription antitermination factor activity, RNA binding
H1Z14_RS14975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H1Z14_RS14980	COG0088	Forms part of the polypeptide exit tunnel
H1Z14_RS14985	COG0089	rRNA binding
H1Z14_RS14990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H1Z14_RS14995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H1Z14_RS15000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H1Z14_RS15005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H1Z14_RS15010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H1Z14_RS15015	COG0255	Belongs to the universal ribosomal protein uL29 family
H1Z14_RS15020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H1Z14_RS15025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H1Z14_RS15030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H1Z14_RS15035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H1Z14_RS15040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H1Z14_RS15045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H1Z14_RS15050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H1Z14_RS15055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H1Z14_RS15060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H1Z14_RS15065	COG1841	ribosomal large subunit assembly
H1Z14_RS15070	COG0200	Binds to the 23S rRNA
H1Z14_RS15075	COG0201	protein transport
H1Z14_RS15080	COG0563	adenylate kinase activity
H1Z14_RS15085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H1Z14_RS15090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H1Z14_RS15095	COG0202	RNA polymerase activity
H1Z14_RS15100	COG0203	ribosomal protein L17
H1Z14_RS15115	COG2897	thiosulfate sulfurtransferase activity
H1Z14_RS15125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1Z14_RS15130	COG0415	Belongs to the DNA photolyase family
H1Z14_RS15140	COG0739	heme binding
H1Z14_RS15145	COG2833	Protein of unknown function (DUF455)
H1Z14_RS15150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1Z14_RS15175	COG0280	phosphate acetyltransferase
H1Z14_RS15175	COG0281	malic enzyme
H1Z14_RS15185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1Z14_RS15190	COG1127	ABC transporter
H1Z14_RS15200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1Z14_RS15200	COG3218	ABC-type transport auxiliary lipoprotein component
H1Z14_RS15205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1Z14_RS15225	COG0047	phosphoribosylformylglycinamidine synthase activity
H1Z14_RS15230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1Z14_RS15235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1Z14_RS15250	COG3706	GGDEF domain
H1Z14_RS15260	COG0538	isocitrate dehydrogenase activity
H1Z14_RS15265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H1Z14_RS15270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1Z14_RS15280	COG1253	flavin adenine dinucleotide binding
H1Z14_RS15290	COG0657	acetylesterase activity
H1Z14_RS15290	COG2755	lipolytic protein G-D-S-L family
H1Z14_RS15295	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1Z14_RS15310	COG0861	Integral membrane protein TerC family
H1Z14_RS15315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H1Z14_RS15320	COG2066	Belongs to the glutaminase family
H1Z14_RS15330	COG0037	tRNA processing
H1Z14_RS15335	COG0483	inositol monophosphate 1-phosphatase activity
H1Z14_RS15340	COG0483	inositol monophosphate 1-phosphatase activity
H1Z14_RS15345	COG2814	Major facilitator Superfamily
H1Z14_RS15350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1Z14_RS15365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1Z14_RS15370	COG0484	heat shock protein binding
H1Z14_RS15385	COG0321	lipoyl(octanoyl) transferase activity
H1Z14_RS15415	COG1396	sequence-specific DNA binding
H1Z14_RS15450	COG0250	Participates in transcription elongation, termination and antitermination
H1Z14_RS15530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1Z14_RS15535	COG1091	dTDP-4-dehydrorhamnose reductase activity
H1Z14_RS15540	COG1088	dTDP-glucose 4,6-dehydratase activity
H1Z14_RS15545	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H1Z14_RS15665	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H1Z14_RS15670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1Z14_RS15700	COG0242	peptide deformylase activity
H1Z14_RS15710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1Z14_RS15715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1Z14_RS15720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1Z14_RS15725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Z14_RS15730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1Z14_RS15755	COG0823	Involved in the tonB-independent uptake of proteins
H1Z14_RS15760	COG0778	Nitroreductase
H1Z14_RS15770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1Z14_RS15775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1Z14_RS15795	COG2202	Pas domain
H1Z14_RS15795	COG2205	protein histidine kinase activity
H1Z14_RS15805	COG1573	uracil-dna glycosylase
H1Z14_RS15810	COG1522	sequence-specific DNA binding
H1Z14_RS15815	COG2084	Dehydrogenase
H1Z14_RS15820	COG2267	carboxylic ester hydrolase activity
H1Z14_RS15830	COG5425	PFAM Usg family protein
H1Z14_RS15855	COG1763	Mo-molybdopterin cofactor biosynthetic process
H1Z14_RS15860	COG0746	molybdenum cofactor guanylyltransferase activity
H1Z14_RS15870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1Z14_RS15880	COG3706	GGDEF domain
H1Z14_RS15890	COG0114	fumarate hydratase activity
H1Z14_RS15895	COG2989	Protein conserved in bacteria
H1Z14_RS15900	COG0546	phosphoglycolate phosphatase activity
H1Z14_RS15905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H1Z14_RS15920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H1Z14_RS15960	COG5001	Diguanylate cyclase
H1Z14_RS15960	COG4251	negative regulation of phosphorylation
H1Z14_RS15960	COG3706	GGDEF domain
H1Z14_RS15960	COG2203	Gaf domain
H1Z14_RS15965	COG0556	nucleotide-excision repair
H1Z14_RS15985	COG3161	chorismate lyase activity
H1Z14_RS15995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H1Z14_RS16000	COG0148	phosphopyruvate hydratase activity
H1Z14_RS16010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1Z14_RS16015	COG0022	dehydrogenase e1 component
H1Z14_RS16015	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Z14_RS16020	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1Z14_RS16040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1Z14_RS16050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1Z14_RS16070	COG0477	Major facilitator Superfamily
H1Z14_RS16075	COG2867	negative regulation of translational initiation
H1Z14_RS16080	COG1058	Belongs to the CinA family
H1Z14_RS16080	COG1546	Belongs to the CinA family
H1Z14_RS16085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H1Z14_RS16085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H1Z14_RS16095	COG3852	Histidine kinase
H1Z14_RS16100	COG2204	response regulator
H1Z14_RS16105	COG5000	phosphorelay sensor kinase activity
H1Z14_RS16110	COG2204	response regulator
H1Z14_RS16115	COG1923	regulation of RNA biosynthetic process
H1Z14_RS16120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1Z14_RS16130	COG3956	TIGRFAM MazG family protein
H1Z14_RS16140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1Z14_RS16140	COG1648	precorrin-2 dehydrogenase activity
H1Z14_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS16175	COG1686	Belongs to the peptidase S11 family
H1Z14_RS16180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H1Z14_RS16190	COG0730	response to heat
H1Z14_RS16195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1Z14_RS16200	COG0084	hydrolase, TatD family'
H1Z14_RS16205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1Z14_RS16205	COG0321	lipoyl(octanoyl) transferase activity
H1Z14_RS16220	COG0785	Cytochrome C biogenesis protein
H1Z14_RS16225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Z14_RS16230	COG1183	phosphatidylcholine synthase activity
H1Z14_RS16235	COG1129	ABC transporter
H1Z14_RS16255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1Z14_RS16260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1Z14_RS16280	COG1177	transmembrane transport
H1Z14_RS16285	COG4149	molybdate abc transporter
H1Z14_RS16290	COG3842	ATPase activity
H1Z14_RS16300	COG1940	carbohydrate kinase activity
H1Z14_RS16305	COG0523	cobalamin synthesis protein
H1Z14_RS16315	COG1121	(ABC) transporter
H1Z14_RS16320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1Z14_RS16325	COG0735	belongs to the Fur family
H1Z14_RS16345	COG1686	Belongs to the peptidase S11 family
H1Z14_RS16380	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1Z14_RS16385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1Z14_RS16390	COG0302	gtp cyclohydrolase
H1Z14_RS16400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H1Z14_RS16405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H1Z14_RS16420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1Z14_RS16425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1Z14_RS16470	COG0187	DNA topoisomerase II activity
H1Z14_RS16485	COG0149	triose-phosphate isomerase activity
H1Z14_RS16495	COG0504	CTP synthase activity
H1Z14_RS16520	COG0633	Ferredoxin
H1Z14_RS16530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1Z14_RS16570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1Z14_RS16570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1Z14_RS16575	COG0509	glycine decarboxylation via glycine cleavage system
H1Z14_RS16580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Z14_RS16600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H1Z14_RS16605	COG0564	pseudouridine synthase activity
H1Z14_RS16610	COG0546	phosphoglycolate phosphatase activity
H1Z14_RS16625	COG0477	Major facilitator Superfamily
H1Z14_RS16640	COG2003	Belongs to the UPF0758 family
H1Z14_RS16645	COG0024	Methionine aminopeptidase
H1Z14_RS16650	COG0583	DNA-binding transcription factor activity
H1Z14_RS16655	COG2855	membrane
H1Z14_RS16660	COG1489	DNA binding
H1Z14_RS16665	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1Z14_RS16675	COG0436	Aminotransferase
H1Z14_RS16685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1Z14_RS16710	COG0346	lactoylglutathione lyase activity
H1Z14_RS16715	COG1278	Cold shock
H1Z14_RS16750	COG0587	DNA-directed DNA polymerase activity
H1Z14_RS16790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1Z14_RS16800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1Z14_RS16805	COG1280	lysine exporter protein (LysE YggA)
H1Z14_RS16815	COG0697	spore germination
H1Z14_RS16845	COG0174	glutamine synthetase
H1Z14_RS16850	COG0347	Belongs to the P(II) protein family
H1Z14_RS16855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1Z14_RS16855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1Z14_RS16870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1Z14_RS16875	COG0629	single-stranded DNA binding
H1Z14_RS16885	COG2095	MarC family integral membrane protein
H1Z14_RS16890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1Z14_RS16895	COG2217	Heavy metal translocating P-type atpase
H1Z14_RS16920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H1Z14_RS16935	COG1653	transport
H1Z14_RS16940	COG1175	transmembrane transport
H1Z14_RS16945	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS16950	COG3842	ATPase activity
H1Z14_RS16970	COG0667	Aldo Keto reductase
H1Z14_RS16975	COG3507	Belongs to the glycosyl hydrolase 43 family
H1Z14_RS16990	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H1Z14_RS16995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H1Z14_RS17000	COG0129	dihydroxy-acid dehydratase activity
H1Z14_RS17020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1Z14_RS17045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Z14_RS17060	COG0513	Belongs to the DEAD box helicase family
H1Z14_RS17070	COG2945	thiolester hydrolase activity
H1Z14_RS17075	COG1104	cysteine desulfurase activity
H1Z14_RS17080	COG0719	Fe-S assembly protein
H1Z14_RS17090	COG0396	ATPase activity
H1Z14_RS17095	COG0719	Fe-S assembly protein
H1Z14_RS17105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1Z14_RS17110	COG2151	metal-sulfur cluster biosynthetic enzyme
H1Z14_RS17125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H1Z14_RS17140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H1Z14_RS17145	COG0343	queuine tRNA-ribosyltransferase activity
H1Z14_RS17165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H1Z14_RS17170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Z14_RS17175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1Z14_RS17180	COG2080	2 iron, 2 sulfur cluster binding
H1Z14_RS17210	COG2062	phosphohistidine phosphatase, SixA
H1Z14_RS17215	COG3106	COG3106 Predicted ATPase
H1Z14_RS17220	COG3768	UPF0283 membrane protein
H1Z14_RS17235	COG0436	Aminotransferase
H1Z14_RS17245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1Z14_RS17250	COG0544	peptidyl-prolyl cis-trans isomerase activity
H1Z14_RS17280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1Z14_RS17285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1Z14_RS17300	COG0252	asparaginase activity
H1Z14_RS17310	COG0737	Belongs to the 5'-nucleotidase family
H1Z14_RS17320	COG0463	Glycosyl transferase, family 2
H1Z14_RS17335	COG4303	Ethanolamine ammonia lyase large subunit
H1Z14_RS17340	COG4302	ethanolamine ammonia-lyase activity
H1Z14_RS17345	COG1192	Involved in chromosome partitioning
H1Z14_RS17350	COG1475	DNA binding
H1Z14_RS17355	COG1414	Transcriptional regulator
H1Z14_RS17360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1Z14_RS17365	COG0392	lysyltransferase activity
H1Z14_RS17375	COG3257	ureidoglycine aminohydrolase activity
H1Z14_RS17395	COG1522	sequence-specific DNA binding
H1Z14_RS17420	COG2040	homocysteine
H1Z14_RS17425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS17435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1Z14_RS17440	COG1473	amidohydrolase
H1Z14_RS17450	COG0297	glycogen (starch) synthase activity
H1Z14_RS17475	COG1063	alcohol dehydrogenase
H1Z14_RS17480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1Z14_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS17490	COG3265	gluconokinase activity
H1Z14_RS17495	COG2084	Dehydrogenase
H1Z14_RS17505	COG1609	Transcriptional regulator
H1Z14_RS17520	COG1129	ABC transporter
H1Z14_RS17535	COG1879	ABC-type sugar transport system periplasmic component
H1Z14_RS17540	COG1129	ABC transporter
H1Z14_RS17545	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS17550	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS17555	COG2186	Transcriptional regulator
H1Z14_RS17560	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS17565	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS17575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1Z14_RS17585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS17610	COG0778	Nitroreductase
H1Z14_RS17620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1Z14_RS17625	COG0659	secondary active sulfate transmembrane transporter activity
H1Z14_RS17690	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS17700	COG1802	Transcriptional regulator
H1Z14_RS17705	COG0747	negative chemotaxis
H1Z14_RS17710	COG2723	6-phospho-beta-galactosidase activity
H1Z14_RS17715	COG0601	transmembrane transport
H1Z14_RS17725	COG3964	amidohydrolase
H1Z14_RS17740	COG1921	L-seryl-tRNASec selenium transferase activity
H1Z14_RS17745	COG3706	GGDEF domain
H1Z14_RS17745	COG2203	Gaf domain
H1Z14_RS17745	COG4251	negative regulation of phosphorylation
H1Z14_RS17745	COG5001	Diguanylate cyclase
H1Z14_RS17765	COG2080	2 iron, 2 sulfur cluster binding
H1Z14_RS17770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H1Z14_RS17775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Z14_RS17800	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS17810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1Z14_RS17815	COG1486	melibiose metabolic process
H1Z14_RS17820	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS17825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS17830	COG0601	transmembrane transport
H1Z14_RS17835	COG0747	negative chemotaxis
H1Z14_RS17840	COG1486	melibiose metabolic process
H1Z14_RS17845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H1Z14_RS17845	COG2207	Transcriptional regulator
H1Z14_RS17860	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS17875	COG1063	alcohol dehydrogenase
H1Z14_RS17880	COG4948	Mandelate Racemase Muconate Lactonizing
H1Z14_RS17900	COG4214	carbohydrate transport
H1Z14_RS17905	COG1129	ABC transporter
H1Z14_RS17920	COG1175	transmembrane transport
H1Z14_RS17925	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS17945	COG1609	Transcriptional regulator
H1Z14_RS17960	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS17975	COG2972	Histidine kinase
H1Z14_RS17975	COG0840	transmembrane signaling receptor activity
H1Z14_RS18000	COG0667	Aldo Keto reductase
H1Z14_RS18015	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS18025	COG4213	ABC transporter substrate-binding protein
H1Z14_RS18040	COG1129	ABC transporter
H1Z14_RS18045	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS18050	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS18065	COG0765	amino acid transport
H1Z14_RS18070	COG1126	abc transporter atp-binding protein
H1Z14_RS18075	COG2079	MmgE PrpD family protein
H1Z14_RS18080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS18095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS18110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS18120	COG0747	negative chemotaxis
H1Z14_RS18135	COG2197	response regulator
H1Z14_RS18140	COG3850	Histidine kinase
H1Z14_RS18140	COG5002	protein histidine kinase activity
H1Z14_RS18145	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H1Z14_RS18155	COG2731	YhcH YjgK YiaL family protein
H1Z14_RS18160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS18165	COG2271	Major facilitator Superfamily
H1Z14_RS18170	COG1609	Transcriptional regulator
H1Z14_RS18175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS18180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS18185	COG1473	amidohydrolase
H1Z14_RS18210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS18215	COG2205	protein histidine kinase activity
H1Z14_RS18220	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS18230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Z14_RS18250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Z14_RS18260	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS18270	COG1309	transcriptional regulator
H1Z14_RS18300	COG2207	Transcriptional regulator
H1Z14_RS18310	COG0235	Class ii aldolase
H1Z14_RS18330	COG4221	oxidoreductase activity
H1Z14_RS18360	COG1595	DNA-templated transcription, initiation
H1Z14_RS18365	COG2824	Alkylphosphonate utilization operon protein PhnA
H1Z14_RS18390	COG3833	ABC-type maltose transport systems, permease component
H1Z14_RS18395	COG3842	ATPase activity
H1Z14_RS18400	COG0584	glycerophosphoryl diester phosphodiesterase
H1Z14_RS18445	COG1320	monovalent cation:proton antiporter activity
H1Z14_RS18450	COG2212	antiporter activity
H1Z14_RS18455	COG1863	multisubunit Na H antiporter MnhE subunit
H1Z14_RS18460	COG0651	ATP synthesis coupled electron transport
H1Z14_RS18465	COG1006	Multisubunit Na H antiporter MnhC subunit
H1Z14_RS18470	COG2111	Na H antiporter
H1Z14_RS18470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1Z14_RS18505	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS18510	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS18525	COG2072	flavoprotein involved in K transport
H1Z14_RS18530	COG1177	transmembrane transport
H1Z14_RS18535	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS18540	COG3842	ATPase activity
H1Z14_RS18545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1Z14_RS18550	COG0583	DNA-binding transcription factor activity
H1Z14_RS18585	COG4608	Belongs to the ABC transporter superfamily
H1Z14_RS18610	COG0601	transmembrane transport
H1Z14_RS18615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS18635	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS18640	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS18645	COG1846	Transcriptional regulator
H1Z14_RS18675	COG0625	glutathione transferase activity
H1Z14_RS18695	COG2133	pyrroloquinoline quinone binding
H1Z14_RS18705	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS18720	COG0753	catalase activity
H1Z14_RS18725	COG0306	phosphate transporter
H1Z14_RS18730	COG3842	ATPase activity
H1Z14_RS18735	COG1175	transmembrane transport
H1Z14_RS18740	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS18765	COG3684	Belongs to the aldolase LacD family
H1Z14_RS18770	COG2390	Transcriptional regulator
H1Z14_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS18795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS18800	COG0626	cystathionine gamma-synthase activity
H1Z14_RS18805	COG1725	Transcriptional regulator
H1Z14_RS18810	COG0747	negative chemotaxis
H1Z14_RS18825	COG0444	Belongs to the ABC transporter superfamily
H1Z14_RS18830	COG4608	Belongs to the ABC transporter superfamily
H1Z14_RS18835	COG0006	proline dipeptidase activity
H1Z14_RS18845	COG0747	negative chemotaxis
H1Z14_RS18860	COG0405	Gamma-glutamyltransferase
H1Z14_RS18870	COG0754	glutathionylspermidine amidase activity
H1Z14_RS18880	COG3766	membrane
H1Z14_RS18890	COG3789	protein conserved in bacteria
H1Z14_RS18905	COG0318	PFAM AMP-dependent synthetase and ligase
H1Z14_RS18915	COG1802	Transcriptional regulator
H1Z14_RS18925	COG0601	transmembrane transport
H1Z14_RS18955	COG0747	negative chemotaxis
H1Z14_RS18965	COG2205	protein histidine kinase activity
H1Z14_RS18970	COG2197	response regulator
H1Z14_RS18975	COG4585	Histidine kinase
H1Z14_RS18990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1Z14_RS18995	COG4208	sulfate ABC transporter
H1Z14_RS19000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1Z14_RS19005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1Z14_RS19010	COG1609	Transcriptional regulator
H1Z14_RS19015	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS19025	COG1653	transport
H1Z14_RS19030	COG1175	transmembrane transport
H1Z14_RS19035	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS19040	COG3842	ATPase activity
H1Z14_RS19050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1Z14_RS19065	COG0583	DNA-binding transcription factor activity
H1Z14_RS19070	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS19075	COG3250	beta-galactosidase activity
H1Z14_RS19085	COG1940	carbohydrate kinase activity
H1Z14_RS19090	COG2116	formate transmembrane transporter activity
H1Z14_RS19095	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS19140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1Z14_RS19145	COG0583	DNA-binding transcription factor activity
H1Z14_RS19160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H1Z14_RS19165	COG0402	S-adenosylhomocysteine deaminase activity
H1Z14_RS19175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1Z14_RS19180	COG2080	2 iron, 2 sulfur cluster binding
H1Z14_RS19185	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS19200	COG2186	Transcriptional regulator
H1Z14_RS19205	COG1304	FMN binding
H1Z14_RS19215	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS19260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1Z14_RS19265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1Z14_RS19270	COG1126	abc transporter atp-binding protein
H1Z14_RS19275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS19280	COG0765	amino acid transport
H1Z14_RS19285	COG0765	amino acid transport
H1Z14_RS19295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Z14_RS19305	COG1764	response to oxidative stress
H1Z14_RS19320	COG1116	anion transmembrane transporter activity
H1Z14_RS19325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS19330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS19335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS19340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS19345	COG1959	2 iron, 2 sulfur cluster binding
H1Z14_RS19370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1Z14_RS19405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Z14_RS19425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Z14_RS19435	COG1116	anion transmembrane transporter activity
H1Z14_RS19445	COG4191	Histidine kinase
H1Z14_RS19450	COG4566	intracellular signal transduction
H1Z14_RS19460	COG3842	ATPase activity
H1Z14_RS19465	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS19470	COG1175	transmembrane transport
H1Z14_RS19505	COG1940	carbohydrate kinase activity
H1Z14_RS19510	COG0747	negative chemotaxis
H1Z14_RS19515	COG0601	transmembrane transport
H1Z14_RS19520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS19530	COG4608	Belongs to the ABC transporter superfamily
H1Z14_RS19535	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS19540	COG2205	protein histidine kinase activity
H1Z14_RS19550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS19560	COG2076	Multidrug Resistance protein
H1Z14_RS19580	COG2076	Multidrug Resistance protein
H1Z14_RS19595	COG1215	transferase activity, transferring glycosyl groups
H1Z14_RS19610	COG3920	Histidine kinase
H1Z14_RS19610	COG2202	Pas domain
H1Z14_RS19620	COG0784	Response regulator, receiver
H1Z14_RS19630	COG1162	GTPase activity
H1Z14_RS19635	COG4191	Histidine kinase
H1Z14_RS19635	COG0784	Response regulator, receiver
H1Z14_RS19640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Z14_RS19645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS19645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1Z14_RS19655	COG1126	abc transporter atp-binding protein
H1Z14_RS19660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS19670	COG0840	transmembrane signaling receptor activity
H1Z14_RS19670	COG2972	Histidine kinase
H1Z14_RS19675	COG0835	chemotaxis
H1Z14_RS19685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Z14_RS19700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Z14_RS19710	COG0789	Transcriptional regulator
H1Z14_RS19715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1Z14_RS19720	COG0366	Alpha amylase catalytic
H1Z14_RS19725	COG0366	Alpha amylase catalytic
H1Z14_RS19730	COG1640	4-alpha-glucanotransferase
H1Z14_RS19735	COG1278	Cold shock
H1Z14_RS19740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1Z14_RS19750	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS19760	COG1802	Transcriptional regulator
H1Z14_RS19765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS19775	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS19785	COG1175	transmembrane transport
H1Z14_RS19790	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS19800	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS19810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H1Z14_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS19830	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H1Z14_RS19835	COG3920	Histidine kinase
H1Z14_RS19850	COG3685	Protein conserved in bacteria
H1Z14_RS19880	COG5001	Diguanylate cyclase
H1Z14_RS19885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1Z14_RS19905	COG1132	(ABC) transporter
H1Z14_RS19910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Z14_RS19910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1Z14_RS19925	COG3842	ATPase activity
H1Z14_RS19930	COG3833	ABC-type maltose transport systems, permease component
H1Z14_RS19945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1Z14_RS19975	COG0604	alcohol dehydrogenase
H1Z14_RS19975	COG3321	synthase
H1Z14_RS19995	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS20005	COG4608	Belongs to the ABC transporter superfamily
H1Z14_RS20020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS20025	COG0747	negative chemotaxis
H1Z14_RS20045	COG0583	DNA-binding transcription factor activity
H1Z14_RS20050	COG0747	negative chemotaxis
H1Z14_RS20060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS20075	COG0154	amidase activity
H1Z14_RS20090	COG1335	isochorismatase
H1Z14_RS20095	COG1129	ABC transporter
H1Z14_RS20110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1Z14_RS20135	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS20140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS20145	COG0601	transmembrane transport
H1Z14_RS20175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS20185	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS20195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS20200	COG1309	transcriptional regulator
H1Z14_RS20215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1Z14_RS20230	COG4770	biotin carboxylase activity
H1Z14_RS20245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1Z14_RS20245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1Z14_RS20270	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS20280	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1Z14_RS20280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Z14_RS20285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1Z14_RS20295	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS20300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS20305	COG0601	transmembrane transport
H1Z14_RS20310	COG0747	negative chemotaxis
H1Z14_RS20315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS20320	COG2186	Transcriptional regulator
H1Z14_RS20330	COG0640	Transcriptional regulator
H1Z14_RS20340	COG3842	ATPase activity
H1Z14_RS20345	COG1175	transmembrane transport
H1Z14_RS20350	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS20360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H1Z14_RS20370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS20375	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS20380	COG2084	Dehydrogenase
H1Z14_RS20390	COG3386	PFAM SMP-30 Gluconolaconase
H1Z14_RS20400	COG2771	luxR family
H1Z14_RS20410	COG0626	cystathionine gamma-synthase activity
H1Z14_RS20425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1Z14_RS20460	COG1175	transmembrane transport
H1Z14_RS20465	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS20475	COG3842	ATPase activity
H1Z14_RS20490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1Z14_RS20490	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1Z14_RS20495	COG4311	Sarcosine oxidase, delta subunit
H1Z14_RS20500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS20505	COG4977	sequence-specific DNA binding
H1Z14_RS20515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1Z14_RS20520	COG2218	PFAM glutamate synthase alpha subunit domain protein
H1Z14_RS20525	COG0069	glutamate synthase activity
H1Z14_RS20540	COG1304	FMN binding
H1Z14_RS20555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1Z14_RS20565	COG3842	ATPase activity
H1Z14_RS20570	COG1175	transmembrane transport
H1Z14_RS20575	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS20580	COG1609	Transcriptional regulator
H1Z14_RS20595	COG0412	Dienelactone hydrolase
H1Z14_RS20605	COG0583	DNA-binding transcription factor activity
H1Z14_RS20620	COG0583	DNA-binding transcription factor activity
H1Z14_RS20645	COG0306	phosphate transporter
H1Z14_RS20660	COG0277	FAD linked oxidase domain protein
H1Z14_RS20665	COG0277	FAD linked oxidase domain protein
H1Z14_RS20675	COG0247	lactate metabolic process
H1Z14_RS20685	COG0625	glutathione transferase activity
H1Z14_RS20695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1Z14_RS20700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H1Z14_RS20710	COG2852	Protein conserved in bacteria
H1Z14_RS20715	COG0124	histidyl-tRNA synthetase
H1Z14_RS20755	COG2818	Glycosylase
H1Z14_RS20760	COG1388	LysM domain
H1Z14_RS20760	COG1376	ErfK ybiS ycfS ynhG family protein
H1Z14_RS20765	COG1376	ErfK ybiS ycfS ynhG family protein
H1Z14_RS20770	COG2909	trisaccharide binding
H1Z14_RS20780	COG2137	regulation of response to DNA damage stimulus
H1Z14_RS20785	COG2130	NADP-dependent
H1Z14_RS20800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1Z14_RS20820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS20825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS20840	COG0196	riboflavin kinase activity
H1Z14_RS20850	COG2059	Chromate
H1Z14_RS20855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H1Z14_RS20860	COG0459	protein refolding
H1Z14_RS20880	COG3842	ATPase activity
H1Z14_RS20890	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS20895	COG1177	transmembrane transport
H1Z14_RS20900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1Z14_RS20905	COG0019	diaminopimelate decarboxylase activity
H1Z14_RS20915	COG4770	biotin carboxylase activity
H1Z14_RS20920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H1Z14_RS20925	COG4336	lyase activity
H1Z14_RS20930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H1Z14_RS20935	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Z14_RS20940	COG1802	Transcriptional regulator
H1Z14_RS20945	COG1522	sequence-specific DNA binding
H1Z14_RS20950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1Z14_RS20965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1Z14_RS20975	COG0583	DNA-binding transcription factor activity
H1Z14_RS20980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H1Z14_RS20985	COG0511	ligase activity, forming carbon-carbon bonds
H1Z14_RS20990	COG0439	Biotin carboxylase
H1Z14_RS21000	COG1984	allophanate hydrolase subunit 2
H1Z14_RS21010	COG3842	ATPase activity
H1Z14_RS21015	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS21025	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS21030	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS21040	COG3842	ATPase activity
H1Z14_RS21045	COG0726	polysaccharide deacetylase
H1Z14_RS21055	COG0523	cobalamin synthesis protein
H1Z14_RS21070	COG1522	sequence-specific DNA binding
H1Z14_RS21080	COG0659	secondary active sulfate transmembrane transporter activity
H1Z14_RS21090	COG0243	molybdopterin cofactor binding
H1Z14_RS21100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1Z14_RS21105	COG1116	anion transmembrane transporter activity
H1Z14_RS21110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS21115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS21120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS21125	COG3707	response regulator
H1Z14_RS21150	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS21155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1Z14_RS21170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS21185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H1Z14_RS21200	COG2022	thiamine diphosphate biosynthetic process
H1Z14_RS21380	COG0640	Transcriptional regulator
H1Z14_RS21385	COG0798	PFAM Bile acid sodium symporter
H1Z14_RS21395	COG0431	NADPH-dependent FMN reductase
H1Z14_RS21405	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS21410	COG2205	protein histidine kinase activity
H1Z14_RS21415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H1Z14_RS21425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1Z14_RS21450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS21455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Z14_RS21460	COG1522	sequence-specific DNA binding
H1Z14_RS21475	COG2267	carboxylic ester hydrolase activity
H1Z14_RS21485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS21505	COG1177	transmembrane transport
H1Z14_RS21510	COG3842	ATPase activity
H1Z14_RS21515	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS21525	COG4154	Belongs to the RbsD FucU family
H1Z14_RS21535	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS21540	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS21545	COG1129	ABC transporter
H1Z14_RS21565	COG2721	sulfolactate sulfo-lyase activity
H1Z14_RS21575	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS21585	COG2205	protein histidine kinase activity
H1Z14_RS21590	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS21625	COG0183	Belongs to the thiolase family
H1Z14_RS21630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1Z14_RS21640	COG1414	Transcriptional regulator
H1Z14_RS21655	COG0583	DNA-binding transcription factor activity
H1Z14_RS21665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1Z14_RS21670	COG3485	protocatechuate 3,4-dioxygenase
H1Z14_RS21675	COG3485	protocatechuate 3,4-dioxygenase
H1Z14_RS21680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1Z14_RS21685	COG0604	alcohol dehydrogenase
H1Z14_RS21690	COG1674	ftsk spoiiie
H1Z14_RS21695	COG3842	ATPase activity
H1Z14_RS21710	COG0668	transmembrane transport
H1Z14_RS21725	COG5265	(ABC) transporter
H1Z14_RS21730	COG2205	protein histidine kinase activity
H1Z14_RS21735	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS21750	COG3346	SURF1 family
H1Z14_RS21755	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1Z14_RS21760	COG1845	cytochrome c oxidase, subunit III
H1Z14_RS21765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1Z14_RS21775	COG1595	DNA-templated transcription, initiation
H1Z14_RS21785	COG0670	Belongs to the BI1 family
H1Z14_RS21800	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H1Z14_RS21800	COG2273	Hydrolase Family 16
H1Z14_RS21805	COG1301	dicarboxylic acid transport
H1Z14_RS21810	COG4191	Histidine kinase
H1Z14_RS21815	COG2204	response regulator
H1Z14_RS21820	COG1309	transcriptional regulator
H1Z14_RS21840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H1Z14_RS21845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1Z14_RS21850	COG2188	Transcriptional regulator
H1Z14_RS21865	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS21875	COG3842	ATPase activity
H1Z14_RS21900	COG1737	Transcriptional regulator
H1Z14_RS21900	COG0837	glucose binding
H1Z14_RS21905	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS21925	COG3142	Participates in the control of copper homeostasis
H1Z14_RS21945	COG0642	Histidine kinase
H1Z14_RS21950	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS21965	COG4952	isomerase
H1Z14_RS21970	COG3347	Dehydrogenase
H1Z14_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS21985	COG1129	ABC transporter
H1Z14_RS21990	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS22000	COG3254	rhamnose metabolic process
H1Z14_RS22010	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS22030	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS22040	COG3842	ATPase activity
H1Z14_RS22060	COG2094	Belongs to the DNA glycosylase MPG family
H1Z14_RS22065	COG1136	(ABC) transporter
H1Z14_RS22075	COG1737	Transcriptional regulator
H1Z14_RS22095	COG3177	Filamentation induced by cAMP protein fic
H1Z14_RS22100	COG1069	ribulokinase activity
H1Z14_RS22110	COG4214	carbohydrate transport
H1Z14_RS22135	COG2814	Major facilitator Superfamily
H1Z14_RS22155	COG1780	Probably involved in ribonucleotide reductase function
H1Z14_RS22165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1Z14_RS22170	COG0640	Transcriptional regulator
H1Z14_RS22175	COG1902	pentaerythritol trinitrate reductase activity
H1Z14_RS22180	COG0154	amidase activity
H1Z14_RS22200	COG0583	DNA-binding transcription factor activity
H1Z14_RS22210	COG2423	ornithine cyclodeaminase activity
H1Z14_RS22220	COG0251	oxidation-reduction process
H1Z14_RS22225	COG1414	Transcriptional regulator
H1Z14_RS22235	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS22250	COG1414	Transcriptional regulator
H1Z14_RS22270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1Z14_RS22285	COG2271	Major facilitator Superfamily
H1Z14_RS22290	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS22315	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS22320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1Z14_RS22340	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1Z14_RS22400	COG3485	protocatechuate 3,4-dioxygenase
H1Z14_RS22420	COG1177	transmembrane transport
H1Z14_RS22425	COG3842	ATPase activity
H1Z14_RS22430	COG1940	carbohydrate kinase activity
H1Z14_RS22440	COG0673	inositol 2-dehydrogenase activity
H1Z14_RS22465	COG1573	uracil-dna glycosylase
H1Z14_RS22490	COG1609	Transcriptional regulator
H1Z14_RS22505	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS22510	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H1Z14_RS22550	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS22555	COG2205	protein histidine kinase activity
H1Z14_RS22575	COG0697	spore germination
H1Z14_RS22580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H1Z14_RS22610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS22620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1Z14_RS22625	COG1522	sequence-specific DNA binding
H1Z14_RS22635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H1Z14_RS22645	COG0601	transmembrane transport
H1Z14_RS22650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS22655	COG0444	Belongs to the ABC transporter superfamily
H1Z14_RS22660	COG4608	Belongs to the ABC transporter superfamily
H1Z14_RS22720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H1Z14_RS22730	COG2986	histidine ammonia-lyase
H1Z14_RS22745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1Z14_RS22775	COG3501	Rhs element vgr protein
H1Z14_RS22815	COG2826	transposase and inactivated derivatives, IS30 family
H1Z14_RS22835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H1Z14_RS22845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1Z14_RS22860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1Z14_RS22870	COG2144	transferase activity, transferring acyl groups
H1Z14_RS22875	COG0438	transferase activity, transferring glycosyl groups
H1Z14_RS22885	COG2072	flavoprotein involved in K transport
H1Z14_RS22900	COG0243	molybdopterin cofactor binding
H1Z14_RS22925	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS22940	COG1309	transcriptional regulator
H1Z14_RS22950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Z14_RS22960	COG1177	transmembrane transport
H1Z14_RS22970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1Z14_RS22995	COG2186	Transcriptional regulator
H1Z14_RS23010	COG0747	negative chemotaxis
H1Z14_RS23020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS23040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1Z14_RS23050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS23055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H1Z14_RS23065	COG1999	signal sequence binding
H1Z14_RS23085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1Z14_RS23090	COG0243	molybdopterin cofactor binding
H1Z14_RS23095	COG0662	Cupin 2, conserved barrel domain protein
H1Z14_RS23095	COG2207	Transcriptional regulator
H1Z14_RS23135	COG3284	Transcriptional regulator
H1Z14_RS23140	COG1063	alcohol dehydrogenase
H1Z14_RS23150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1Z14_RS23160	COG0511	ligase activity, forming carbon-carbon bonds
H1Z14_RS23165	COG0439	Biotin carboxylase
H1Z14_RS23170	COG0511	ligase activity, forming carbon-carbon bonds
H1Z14_RS23180	COG1984	allophanate hydrolase subunit 2
H1Z14_RS23185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H1Z14_RS23190	COG0436	Aminotransferase
H1Z14_RS23200	COG4221	oxidoreductase activity
H1Z14_RS23205	COG0765	amino acid transport
H1Z14_RS23210	COG0765	amino acid transport
H1Z14_RS23220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS23235	COG0247	lactate metabolic process
H1Z14_RS23235	COG2181	nitrate reductase activity
H1Z14_RS23240	COG0277	FAD linked oxidase domain protein
H1Z14_RS23275	COG0318	PFAM AMP-dependent synthetase and ligase
H1Z14_RS23285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1Z14_RS23290	COG1024	Enoyl-CoA hydratase
H1Z14_RS23310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1Z14_RS23325	COG1192	Involved in chromosome partitioning
H1Z14_RS23330	COG1475	DNA binding
H1Z14_RS23335	COG0640	Transcriptional regulator
H1Z14_RS23340	COG2072	flavoprotein involved in K transport
H1Z14_RS23345	COG3706	GGDEF domain
H1Z14_RS23505	COG1802	Transcriptional regulator
H1Z14_RS23510	COG0667	Aldo Keto reductase
H1Z14_RS23515	COG0243	molybdopterin cofactor binding
H1Z14_RS23520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H1Z14_RS23540	COG0735	belongs to the Fur family
H1Z14_RS23575	COG0175	sulfate reduction
H1Z14_RS23605	COG1733	regulation of RNA biosynthetic process
H1Z14_RS23620	COG0596	Alpha beta hydrolase
H1Z14_RS23630	COG2610	gluconate transmembrane transporter activity
H1Z14_RS23645	COG1280	lysine exporter protein (LysE YggA)
H1Z14_RS23660	COG0017	Asparaginyl-tRNA synthetase
H1Z14_RS23670	COG0574	Belongs to the PEP-utilizing enzyme family
H1Z14_RS23670	COG3848	Pyruvate phosphate dikinase
H1Z14_RS23675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H1Z14_RS23680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1Z14_RS23705	COG0583	DNA-binding transcription factor activity
H1Z14_RS23710	COG2814	Major facilitator Superfamily
H1Z14_RS23720	COG1335	isochorismatase
H1Z14_RS23725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS23730	COG0154	amidase activity
H1Z14_RS23735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Z14_RS23750	COG3833	ABC-type maltose transport systems, permease component
H1Z14_RS23755	COG3842	ATPase activity
H1Z14_RS23770	COG3609	addiction module antidote protein, CC2985 family
H1Z14_RS23795	COG4957	zinc ion binding
H1Z14_RS23815	COG2226	methyltransferase
H1Z14_RS23880	COG4521	taurine ABC transporter
H1Z14_RS23885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1Z14_RS23890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS23895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS23920	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS23925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS23930	COG0601	transmembrane transport
H1Z14_RS23950	COG1960	acyl-CoA dehydrogenase activity
H1Z14_RS23960	COG0747	negative chemotaxis
H1Z14_RS23975	COG0444	Belongs to the ABC transporter superfamily
H1Z14_RS23985	COG0667	Aldo Keto reductase
H1Z14_RS23995	COG0778	Nitroreductase
H1Z14_RS24000	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS24005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS24015	COG0747	negative chemotaxis
H1Z14_RS24025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS24030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS24035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1Z14_RS24045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS24065	COG0747	negative chemotaxis
H1Z14_RS24070	COG0747	negative chemotaxis
H1Z14_RS24075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS24090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS24095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS24105	COG0747	negative chemotaxis
H1Z14_RS24115	COG0747	negative chemotaxis
H1Z14_RS24120	COG1473	amidohydrolase
H1Z14_RS24125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS24135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1Z14_RS24145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1Z14_RS24150	COG0765	amino acid transport
H1Z14_RS24155	COG1126	abc transporter atp-binding protein
H1Z14_RS24170	COG2011	ABC-type metal ion transport system permease component
H1Z14_RS24180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1Z14_RS24240	COG3938	Belongs to the proline racemase family
H1Z14_RS24245	COG4176	ABC-type proline glycine betaine transport system permease component
H1Z14_RS24250	COG4176	ABC-type proline glycine betaine transport system permease component
H1Z14_RS24255	COG3448	diguanylate cyclase activity
H1Z14_RS24255	COG4175	Glycine betaine
H1Z14_RS24265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS24270	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS24275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1Z14_RS24280	COG2186	Transcriptional regulator
H1Z14_RS24285	COG1802	Transcriptional regulator
H1Z14_RS24310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS24315	COG1349	DNA-binding transcription factor activity
H1Z14_RS24325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS24330	COG0601	transmembrane transport
H1Z14_RS24405	COG1120	ATPase activity
H1Z14_RS24410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS24415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1Z14_RS24420	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H1Z14_RS24425	COG4774	siderophore transport
H1Z14_RS24425	COG1629	transport
H1Z14_RS24475	COG2226	methyltransferase
H1Z14_RS24485	COG0318	PFAM AMP-dependent synthetase and ligase
H1Z14_RS24505	COG0534	Mate efflux family protein
H1Z14_RS24510	COG1959	2 iron, 2 sulfur cluster binding
H1Z14_RS24535	COG0840	transmembrane signaling receptor activity
H1Z14_RS24550	COG2362	D-Aminopeptidase
H1Z14_RS24555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS24570	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS24585	COG1940	carbohydrate kinase activity
H1Z14_RS24595	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS24600	COG1175	transmembrane transport
H1Z14_RS24615	COG0110	maltose O-acetyltransferase activity
H1Z14_RS24645	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS24650	COG1175	transmembrane transport
H1Z14_RS24665	COG2186	Transcriptional regulator
H1Z14_RS24680	COG3842	ATPase activity
H1Z14_RS24690	COG1175	transmembrane transport
H1Z14_RS24695	COG0395	ABC-type sugar transport system, permease component
H1Z14_RS24705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS24725	COG4251	negative regulation of phosphorylation
H1Z14_RS24740	COG0840	transmembrane signaling receptor activity
H1Z14_RS24775	COG0840	transmembrane signaling receptor activity
H1Z14_RS24840	COG0784	Response regulator, receiver
H1Z14_RS24840	COG4191	Histidine kinase
H1Z14_RS24865	COG4191	Histidine kinase
H1Z14_RS24865	COG0784	Response regulator, receiver
H1Z14_RS24915	COG0784	Response regulator, receiver
H1Z14_RS24915	COG2205	protein histidine kinase activity
H1Z14_RS24915	COG2198	Histidine kinase
H1Z14_RS24925	COG0643	Histidine kinase
H1Z14_RS24925	COG0784	Response regulator, receiver
H1Z14_RS24925	COG2198	Histidine kinase
H1Z14_RS24930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Z14_RS24935	COG2201	protein-glutamate methylesterase activity
H1Z14_RS24940	COG0835	chemotaxis
H1Z14_RS24990	COG0583	DNA-binding transcription factor activity
H1Z14_RS25025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H1Z14_RS25035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1Z14_RS25070	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1Z14_RS25105	COG0006	proline dipeptidase activity
H1Z14_RS25115	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS25135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1Z14_RS25140	COG2188	Transcriptional regulator
H1Z14_RS25165	COG0187	DNA topoisomerase II activity
H1Z14_RS25170	COG0187	DNA topoisomerase II activity
H1Z14_RS25190	COG0436	Aminotransferase
H1Z14_RS25200	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H1Z14_RS25205	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
H1Z14_RS25215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1Z14_RS25220	COG2222	sugar isomerase
H1Z14_RS25225	COG2188	Transcriptional regulator
H1Z14_RS25235	COG0601	transmembrane transport
H1Z14_RS25270	COG3547	Transposase (IS116 IS110 IS902 family)
H1Z14_RS25305	COG1473	amidohydrolase
H1Z14_RS25325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1Z14_RS25330	COG1301	dicarboxylic acid transport
H1Z14_RS25335	COG0583	DNA-binding transcription factor activity
H1Z14_RS25340	COG2159	amidohydrolase
H1Z14_RS25365	COG3181	Tripartite tricarboxylate transporter family receptor
H1Z14_RS25370	COG2814	Major facilitator Superfamily
H1Z14_RS25400	COG1609	Transcriptional regulator
H1Z14_RS25440	COG0601	transmembrane transport
H1Z14_RS25460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1Z14_RS25465	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS25470	COG3842	ATPase activity
H1Z14_RS25480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS25485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1Z14_RS25490	COG3284	Transcriptional regulator
H1Z14_RS25495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1Z14_RS25505	COG1012	belongs to the aldehyde dehydrogenase family
H1Z14_RS25515	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS25660	COG3701	Conjugal transfer protein
H1Z14_RS25665	COG3846	protein secretion by the type IV secretion system
H1Z14_RS25675	COG5314	conjugation
H1Z14_RS25680	COG3451	type IV secretory pathway VirB4
H1Z14_RS25695	COG4962	Type ii secretion system protein e
H1Z14_RS25705	COG1192	Involved in chromosome partitioning
H1Z14_RS25710	COG1475	DNA binding
H1Z14_RS25715	COG0640	Transcriptional regulator
H1Z14_RS25760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1Z14_RS25840	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS25845	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS25865	COG1473	amidohydrolase
H1Z14_RS25885	COG1802	Transcriptional regulator
H1Z14_RS25890	COG3938	Belongs to the proline racemase family
H1Z14_RS25905	COG3938	Belongs to the proline racemase family
H1Z14_RS25930	COG0747	negative chemotaxis
H1Z14_RS25940	COG0444	Belongs to the ABC transporter superfamily
H1Z14_RS25960	COG0583	DNA-binding transcription factor activity
H1Z14_RS25965	COG2814	Major facilitator Superfamily
H1Z14_RS26010	COG1475	DNA binding
H1Z14_RS26025	COG0300	oxidoreductase activity
H1Z14_RS26035	COG5489	Protein of unknown function (DUF736)
H1Z14_RS26040	COG0776	regulation of translation
H1Z14_RS26080	COG3501	Rhs element vgr protein
H1Z14_RS26145	COG2207	Transcriptional regulator
H1Z14_RS26165	COG4598	ABC transporter
H1Z14_RS26180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Z14_RS26190	COG2826	transposase and inactivated derivatives, IS30 family
H1Z14_RS26245	COG1609	Transcriptional regulator
H1Z14_RS26250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1Z14_RS26270	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1Z14_RS26275	COG1129	ABC transporter
H1Z14_RS26280	COG1028	Short-chain dehydrogenase reductase Sdr
H1Z14_RS26285	COG3265	gluconokinase activity
H1Z14_RS26345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Z14_RS26370	COG3437	response regulator, receiver
H1Z14_RS26370	COG3850	Histidine kinase
H1Z14_RS26370	COG2205	protein histidine kinase activity
H1Z14_RS26370	COG4999	Histidine kinase
H1Z14_RS26375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H1Z14_RS26385	COG5002	protein histidine kinase activity
H1Z14_RS26400	COG0840	transmembrane signaling receptor activity
H1Z14_RS26400	COG2972	Histidine kinase
H1Z14_RS26505	COG4297	protein containing double-stranded beta helix domain
H1Z14_RS26530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1Z14_RS26560	COG0640	Transcriptional regulator
H1Z14_RS26565	COG1475	DNA binding
H1Z14_RS26570	COG1192	Involved in chromosome partitioning
H1Z14_RS26580	COG4962	Type ii secretion system protein e
H1Z14_RS26595	COG3451	type IV secretory pathway VirB4
H1Z14_RS26600	COG5314	conjugation
H1Z14_RS26610	COG3846	protein secretion by the type IV secretion system
H1Z14_RS26615	COG3701	Conjugal transfer protein
H1Z14_RS26670	COG4166	transmembrane transport
H1Z14_RS26675	COG0601	transmembrane transport
H1Z14_RS26685	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS26695	COG1840	ABC-type Fe3 transport system, periplasmic component
H1Z14_RS26700	COG3842	ATPase activity
H1Z14_RS26705	COG1177	transmembrane transport
H1Z14_RS26710	COG4149	molybdate abc transporter
H1Z14_RS26855	COG0582	viral genome integration into host DNA
H1Z14_RS26890	COG4974	Belongs to the 'phage' integrase family
H1Z14_RS26905	COG4372	Transposase
H1Z14_RS26925	COG3293	Transposase
H1Z14_RS26980	COG4372	Transposase
H1Z14_RS27055	COG0745	RESPONSE REGULATOR receiver
H1Z14_RS27065	COG1192	Involved in chromosome partitioning
H1Z14_RS27095	COG3415	Transposase
H1Z14_RS27110	COG3293	Transposase
H1Z14_RS27130	COG1192	Involved in chromosome partitioning
H1Z14_RS27170	COG1064	alcohol dehydrogenase
H1Z14_RS27180	COG4172	Belongs to the ABC transporter superfamily
H1Z14_RS27210	COG1840	ABC-type Fe3 transport system, periplasmic component
H1Z14_RS27220	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS27240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1Z14_RS27250	COG0747	negative chemotaxis
H1Z14_RS27260	COG3842	ATPase activity
H1Z14_RS27265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1Z14_RS27270	COG1177	transmembrane transport
H1Z14_RS27275	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1Z14_RS27285	COG1177	transmembrane transport
H1Z14_RS27290	COG1177	transmembrane transport
H1Z14_RS27295	COG3842	ATPase activity
H1Z14_RS27310	COG1522	sequence-specific DNA binding
H1Z14_RS27315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1Z14_RS27380	COG3831	ATPase activity
H1Z14_RS27385	COG0776	regulation of translation
H1Z14_RS27395	COG5489	Protein of unknown function (DUF736)
H1Z14_RS27410	COG0582	viral genome integration into host DNA
H1Z14_RS27415	COG0582	viral genome integration into host DNA
H1Z14_RS27420	COG4974	Belongs to the 'phage' integrase family
H1Z14_RS27485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H1Z14_RS27560	COG1396	sequence-specific DNA binding
H1Z14_RS27645	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H1Z14_RS27690	COG0515	serine threonine protein kinase
H1Z14_RS27695	COG0515	serine threonine protein kinase
H1Z14_RS27695	COG2815	serine threonine protein kinase
H1Z14_RS27740	COG3706	GGDEF domain
H1Z14_RS27750	COG0640	Transcriptional regulator
H1Z14_RS27755	COG1475	DNA binding
H1Z14_RS27760	COG1192	Involved in chromosome partitioning
H1Z14_RS27765	COG4227	nucleotidyltransferase activity
H1Z14_RS27770	COG2184	nucleotidyltransferase activity
H1Z14_RS27800	COG1475	DNA binding
H1Z14_RS27890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1Z14_RS27920	COG0789	Transcriptional regulator
H1Z14_RS28010	COG0789	Transcriptional regulator
H1Z14_RS28015	COG1914	H( )-stimulated, divalent metal cation uptake system
H1Z14_RS28055	COG0741	lytic transglycosylase activity
H1Z14_RS28060	COG3838	Conjugal transfer protein Trbc
H1Z14_RS28070	COG3451	type IV secretory pathway VirB4
H1Z14_RS28075	COG0741	lytic transglycosylase activity
H1Z14_RS28135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1Z14_RS28160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H1Z14_RS28185	COG1802	Transcriptional regulator
H1Z14_RS28205	COG1505	serine-type exopeptidase activity
H1Z14_RS28220	COG1280	lysine exporter protein (LysE YggA)
H1Z14_RS28260	COG0560	Phosphoserine phosphatase
H1Z14_RS28275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1Z14_RS28280	COG1802	Transcriptional regulator
H1Z14_RS28285	COG0456	acetyltransferase
H1Z14_RS28290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1Z14_RS28325	COG4644	lycopene metabolic process
H1Z14_RS28330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs