locus-tag	class	description
MTO99_RS00035	COG1070	Carbohydrate kinase
MTO99_RS00040	COG2115	Belongs to the xylose isomerase family
MTO99_RS00045	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS00050	COG1501	Belongs to the glycosyl hydrolase 31 family
MTO99_RS00065	COG1609	Transcriptional regulator
MTO99_RS00080	COG0395	ABC-type sugar transport system, permease component
MTO99_RS00085	COG4209	transmembrane transport
MTO99_RS00090	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS00095	COG1609	Transcriptional regulator
MTO99_RS00105	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS00110	COG0395	ABC-type sugar transport system, permease component
MTO99_RS00115	COG1175	transmembrane transport
MTO99_RS00125	COG1940	carbohydrate kinase activity
MTO99_RS00130	COG2814	Major facilitator Superfamily
MTO99_RS00135	COG0671	phosphoesterase, PA-phosphatase related
MTO99_RS00150	COG1175	transmembrane transport
MTO99_RS00155	COG0395	ABC-type sugar transport system, permease component
MTO99_RS00160	COG3534	alpha-L-arabinofuranosidase
MTO99_RS00170	COG0277	FAD linked oxidase domain protein
MTO99_RS00230	COG0433	COG0433 Predicted ATPase
MTO99_RS00235	COG0456	acetyltransferase
MTO99_RS00245	COG0521	Mo-molybdopterin cofactor biosynthetic process
MTO99_RS00245	COG0315	cyclic pyranopterin monophosphate synthase activity
MTO99_RS00255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MTO99_RS00275	COG0315	cyclic pyranopterin monophosphate synthase activity
MTO99_RS00305	COG0385	Bile acid
MTO99_RS00320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MTO99_RS00330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MTO99_RS00335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MTO99_RS00345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MTO99_RS00375	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MTO99_RS00385	COG0579	oxidoreductase
MTO99_RS00395	COG0488	(ABC) transporter
MTO99_RS00435	COG0489	protein tyrosine kinase activity
MTO99_RS00440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTO99_RS00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MTO99_RS00455	COG3328	transposase activity
MTO99_RS00480	COG2826	transposase and inactivated derivatives, IS30 family
MTO99_RS00500	COG1216	Glycosyl transferase, family 2
MTO99_RS00515	COG3328	transposase activity
MTO99_RS00520	COG1132	(ABC) transporter
MTO99_RS00540	COG3547	Transposase (IS116 IS110 IS902 family)
MTO99_RS00590	COG0438	transferase activity, transferring glycosyl groups
MTO99_RS00650	COG1215	transferase activity, transferring glycosyl groups
MTO99_RS00660	COG1404	Belongs to the peptidase S8 family
MTO99_RS00665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MTO99_RS00680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MTO99_RS00695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTO99_RS00710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTO99_RS00745	COG1754	DNA topoisomerase type I activity
MTO99_RS00745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MTO99_RS00750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MTO99_RS00755	COG0470	DNA polymerase III
MTO99_RS00775	COG2027	D-alanyl-D-alanine carboxypeptidase
MTO99_RS00780	COG1335	isochorismatase
MTO99_RS00795	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS00805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MTO99_RS00815	COG3971	2-oxopent-4-enoate hydratase activity
MTO99_RS00835	COG0444	Belongs to the ABC transporter superfamily
MTO99_RS00840	COG4172	Belongs to the ABC transporter superfamily
MTO99_RS00845	COG2814	Major facilitator Superfamily
MTO99_RS00850	COG0657	acetylesterase activity
MTO99_RS00860	COG0667	Aldo Keto reductase
MTO99_RS00865	COG1063	alcohol dehydrogenase
MTO99_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS00895	COG3226	Transcriptional regulator
MTO99_RS00905	COG0747	negative chemotaxis
MTO99_RS00915	COG2207	Transcriptional regulator
MTO99_RS00915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTO99_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS00980	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS00985	COG2207	Transcriptional regulator
MTO99_RS01045	COG0395	ABC-type sugar transport system, permease component
MTO99_RS01050	COG0673	inositol 2-dehydrogenase activity
MTO99_RS01060	COG0183	Belongs to the thiolase family
MTO99_RS01085	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MTO99_RS01095	COG0300	oxidoreductase activity
MTO99_RS01110	COG2957	Belongs to the agmatine deiminase family
MTO99_RS01125	COG1132	(ABC) transporter
MTO99_RS01140	COG2313	pseudouridylate synthase activity
MTO99_RS01165	COG0477	Major facilitator Superfamily
MTO99_RS01175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MTO99_RS01180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MTO99_RS01180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MTO99_RS01200	COG1011	Hydrolase
MTO99_RS01210	COG0180	Tryptophanyl-tRNA synthetase
MTO99_RS01215	COG0708	Exodeoxyribonuclease III
MTO99_RS01245	COG2009	succinate dehydrogenase
MTO99_RS01255	COG1744	ABC transporter substrate-binding protein PnrA-like
MTO99_RS01265	COG3845	ABC transporter
MTO99_RS01270	COG4603	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS01275	COG1079	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS01290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MTO99_RS01295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO99_RS01305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO99_RS01320	COG0531	amino acid
MTO99_RS01330	COG4770	biotin carboxylase activity
MTO99_RS01335	COG0424	maF-like protein
MTO99_RS01340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MTO99_RS01370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTO99_RS01400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MTO99_RS01405	COG1316	TRANSCRIPTIONal
MTO99_RS01420	COG1088	dTDP-glucose 4,6-dehydratase activity
MTO99_RS01445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MTO99_RS01450	COG0463	Glycosyl transferase, family 2
MTO99_RS01485	COG1215	transferase activity, transferring glycosyl groups
MTO99_RS01505	COG2826	transposase and inactivated derivatives, IS30 family
MTO99_RS01535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MTO99_RS01560	COG1215	transferase activity, transferring glycosyl groups
MTO99_RS01575	COG0500	methyltransferase
MTO99_RS01590	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS01615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MTO99_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO99_RS01650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MTO99_RS01670	COG0714	Associated with various cellular activities
MTO99_RS01690	COG0745	RESPONSE REGULATOR receiver
MTO99_RS01695	COG5002	protein histidine kinase activity
MTO99_RS01700	COG5401	PFAM Sporulation and spore germination
MTO99_RS01705	COG1040	competence protein
MTO99_RS01710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MTO99_RS01715	COG0653	protein targeting
MTO99_RS01775	COG1595	DNA-templated transcription, initiation
MTO99_RS01785	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO99_RS01785	COG0567	Dehydrogenase, E1 component
MTO99_RS01810	COG1902	pentaerythritol trinitrate reductase activity
MTO99_RS01825	COG1126	abc transporter atp-binding protein
MTO99_RS01830	COG0765	amino acid transport
MTO99_RS01850	COG2814	Major facilitator Superfamily
MTO99_RS01870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MTO99_RS01895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MTO99_RS01905	COG0154	amidase activity
MTO99_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS01925	COG1120	ATPase activity
MTO99_RS01930	COG0667	Aldo Keto reductase
MTO99_RS01955	COG0010	Belongs to the arginase family
MTO99_RS01960	COG1842	Phage shock protein A
MTO99_RS01975	COG1595	DNA-templated transcription, initiation
MTO99_RS01990	COG0018	arginyl-trna synthetase
MTO99_RS02000	COG0019	diaminopimelate decarboxylase activity
MTO99_RS02005	COG0460	homoserine dehydrogenase
MTO99_RS02010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MTO99_RS02015	COG0083	homoserine kinase activity
MTO99_RS02025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MTO99_RS02035	COG1045	serine acetyltransferase
MTO99_RS02045	COG2890	protein-(glutamine-N5) methyltransferase activity
MTO99_RS02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTO99_RS02080	COG0356	it plays a direct role in the translocation of protons across the membrane
MTO99_RS02085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTO99_RS02090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MTO99_RS02095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTO99_RS02100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MTO99_RS02105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MTO99_RS02110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MTO99_RS02115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MTO99_RS02130	COG2818	Glycosylase
MTO99_RS02135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTO99_RS02145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTO99_RS02150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTO99_RS02165	COG0631	protein serine/threonine phosphatase activity
MTO99_RS02180	COG0714	Associated with various cellular activities
MTO99_RS02210	COG3842	ATPase activity
MTO99_RS02215	COG1176	ABC-type spermidine putrescine transport system, permease component I
MTO99_RS02255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MTO99_RS02260	COG0750	zinc metalloprotease
MTO99_RS02265	COG4585	Histidine kinase
MTO99_RS02270	COG2197	response regulator
MTO99_RS02285	COG0183	Belongs to the thiolase family
MTO99_RS02300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MTO99_RS02305	COG0442	prolyl-tRNA aminoacylation
MTO99_RS02320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MTO99_RS02325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MTO99_RS02345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MTO99_RS02350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MTO99_RS02370	COG2807	transmembrane transport
MTO99_RS02375	COG1940	carbohydrate kinase activity
MTO99_RS02380	COG2390	Transcriptional regulator
MTO99_RS02385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MTO99_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS02395	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS02405	COG0584	glycerophosphoryl diester phosphodiesterase
MTO99_RS02410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MTO99_RS02415	COG1937	Protein conserved in bacteria
MTO99_RS02425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTO99_RS02445	COG2252	PERMEase
MTO99_RS02450	COG2233	PERMEase
MTO99_RS02475	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTO99_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS02485	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTO99_RS02490	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS02515	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS02525	COG2186	Transcriptional regulator
MTO99_RS02535	COG0277	FAD linked oxidase domain protein
MTO99_RS02550	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS02560	COG0545	Peptidyl-prolyl cis-trans isomerase
MTO99_RS02595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTO99_RS02610	COG3189	MarR family transcriptional regulator
MTO99_RS02615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MTO99_RS02645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTO99_RS02655	COG1215	transferase activity, transferring glycosyl groups
MTO99_RS02660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS02680	COG1185	polyribonucleotide nucleotidyltransferase activity
MTO99_RS02695	COG1131	(ABC) transporter
MTO99_RS02705	COG4585	Histidine kinase
MTO99_RS02710	COG2197	response regulator
MTO99_RS02725	COG0022	dehydrogenase e1 component
MTO99_RS02730	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO99_RS02735	COG2154	pterin-4-alpha-carbinolamine dehydratase
MTO99_RS02745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTO99_RS02755	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS02760	COG2030	dehydratase
MTO99_RS02770	COG0667	Aldo Keto reductase
MTO99_RS02775	COG0612	Peptidase, M16
MTO99_RS02810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MTO99_RS02820	COG1090	epimerase
MTO99_RS02840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MTO99_RS02855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTO99_RS02860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MTO99_RS02875	COG0577	efflux transmembrane transporter activity
MTO99_RS02885	COG1674	ftsk spoiiie
MTO99_RS02895	COG1546	Belongs to the CinA family
MTO99_RS02895	COG1058	Belongs to the CinA family
MTO99_RS02900	COG1396	sequence-specific DNA binding
MTO99_RS02910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MTO99_RS02920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MTO99_RS02925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MTO99_RS02930	COG1522	sequence-specific DNA binding
MTO99_RS02935	COG2814	Major facilitator Superfamily
MTO99_RS02940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MTO99_RS02945	COG2890	protein-(glutamine-N5) methyltransferase activity
MTO99_RS02950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MTO99_RS02955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MTO99_RS02960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MTO99_RS02965	COG2267	carboxylic ester hydrolase activity
MTO99_RS02970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTO99_RS02980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTO99_RS02985	COG0131	Imidazoleglycerol-phosphate dehydratase
MTO99_RS02990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MTO99_RS02995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MTO99_RS03010	COG1201	RNA secondary structure unwinding
MTO99_RS03015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTO99_RS03025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MTO99_RS03030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MTO99_RS03035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MTO99_RS03040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTO99_RS03045	COG1126	abc transporter atp-binding protein
MTO99_RS03050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTO99_RS03055	COG0765	amino acid transport
MTO99_RS03060	COG0765	amino acid transport
MTO99_RS03065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MTO99_RS03070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTO99_RS03070	COG0072	phenylalanine-tRNA ligase activity
MTO99_RS03080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MTO99_RS03085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MTO99_RS03090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MTO99_RS03095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MTO99_RS03100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MTO99_RS03105	COG0165	Argininosuccinate lyase
MTO99_RS03110	COG2094	Belongs to the DNA glycosylase MPG family
MTO99_RS03125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MTO99_RS03130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTO99_RS03160	COG0647	UMP catabolic process
MTO99_RS03175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MTO99_RS03180	COG0497	DNA recombination
MTO99_RS03185	COG0504	CTP synthase activity
MTO99_RS03205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MTO99_RS03210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MTO99_RS03220	COG0287	Prephenate dehydrogenase
MTO99_RS03225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MTO99_RS03230	COG1160	GTP binding
MTO99_RS03235	COG0477	Major facilitator Superfamily
MTO99_RS03240	COG1872	DUF167
MTO99_RS03270	COG0596	Alpha beta hydrolase
MTO99_RS03310	COG1309	transcriptional regulator
MTO99_RS03325	COG1573	uracil-dna glycosylase
MTO99_RS03340	COG0395	ABC-type sugar transport system, permease component
MTO99_RS03345	COG1175	transmembrane transport
MTO99_RS03355	COG1609	Transcriptional regulator
MTO99_RS03370	COG0025	NhaP-type Na H and K H
MTO99_RS03395	COG3012	SEC-C Motif Domain Protein
MTO99_RS03405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MTO99_RS03450	COG1192	Involved in chromosome partitioning
MTO99_RS03475	COG1940	carbohydrate kinase activity
MTO99_RS03480	COG0204	Acyl-transferase
MTO99_RS03485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MTO99_RS03490	COG0515	serine threonine protein kinase
MTO99_RS03490	COG2815	serine threonine protein kinase
MTO99_RS03495	COG1388	LysM domain
MTO99_RS03495	COG3942	CHAP domain
MTO99_RS03505	COG0142	geranyltranstransferase activity
MTO99_RS03515	COG2001	Belongs to the MraZ family
MTO99_RS03520	COG0275	rRNA processing
MTO99_RS03530	COG0768	penicillin binding
MTO99_RS03535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MTO99_RS03545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTO99_RS03550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MTO99_RS03560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MTO99_RS03565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MTO99_RS03575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MTO99_RS03580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MTO99_RS03585	COG1799	cell septum assembly
MTO99_RS03600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MTO99_RS03610	COG0587	DNA-directed DNA polymerase activity
MTO99_RS03615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MTO99_RS03620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MTO99_RS03625	COG0167	dihydroorotate dehydrogenase activity
MTO99_RS03645	COG1174	glycine betaine transport
MTO99_RS03650	COG1174	glycine betaine transport
MTO99_RS03675	COG1271	oxidase subunit
MTO99_RS03680	COG1294	oxidase, subunit
MTO99_RS03685	COG4988	ABC transporter
MTO99_RS03690	COG1132	(ABC) transporter
MTO99_RS03695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MTO99_RS03695	COG0512	Glutamine amidotransferase of anthranilate synthase
MTO99_RS03700	COG0495	leucyl-tRNA aminoacylation
MTO99_RS03705	COG1596	polysaccharide export
MTO99_RS03705	COG1555	photosystem II stabilization
MTO99_RS03720	COG0268	Binds directly to 16S ribosomal RNA
MTO99_RS03730	COG0481	GTPase activity
MTO99_RS03735	COG4762	Protein conserved in bacteria
MTO99_RS03775	COG1420	regulation of RNA biosynthetic process
MTO99_RS03780	COG0484	heat shock protein binding
MTO99_RS03790	COG0537	adenosine 5'-monophosphoramidase activity
MTO99_RS03800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MTO99_RS03810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MTO99_RS03815	COG4585	Histidine kinase
MTO99_RS03820	COG2197	response regulator
MTO99_RS03825	COG0577	efflux transmembrane transporter activity
MTO99_RS03825	COG1136	(ABC) transporter
MTO99_RS03830	COG0577	efflux transmembrane transporter activity
MTO99_RS03835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MTO99_RS03845	COG1381	Involved in DNA repair and RecF pathway recombination
MTO99_RS03850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MTO99_RS03855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MTO99_RS03865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MTO99_RS03875	COG0442	prolyl-tRNA aminoacylation
MTO99_RS03885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MTO99_RS03895	COG0358	DNA primase activity
MTO99_RS03920	COG0601	transmembrane transport
MTO99_RS03925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS03930	COG4172	Belongs to the ABC transporter superfamily
MTO99_RS03975	COG0242	peptide deformylase activity
MTO99_RS03985	COG0297	glycogen (starch) synthase activity
MTO99_RS04115	COG3328	transposase activity
MTO99_RS04130	COG1309	transcriptional regulator
MTO99_RS04140	COG1136	(ABC) transporter
MTO99_RS04175	COG2197	response regulator
MTO99_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS04215	COG0488	(ABC) transporter
MTO99_RS04225	COG0596	Alpha beta hydrolase
MTO99_RS04230	COG2267	carboxylic ester hydrolase activity
MTO99_RS04235	COG0028	Belongs to the TPP enzyme family
MTO99_RS04250	COG2197	response regulator
MTO99_RS04260	COG1024	Enoyl-CoA hydratase
MTO99_RS04295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTO99_RS04300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTO99_RS04305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTO99_RS04320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MTO99_RS04340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MTO99_RS04365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MTO99_RS04375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MTO99_RS04380	COG0174	glutamine synthetase
MTO99_RS04395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MTO99_RS04400	COG0321	lipoyl(octanoyl) transferase activity
MTO99_RS04410	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO99_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTO99_RS04420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MTO99_RS04430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MTO99_RS04450	COG0187	DNA topoisomerase II activity
MTO99_RS04455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MTO99_RS04480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MTO99_RS04485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MTO99_RS04500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MTO99_RS04505	COG0723	plastoquinol--plastocyanin reductase activity
MTO99_RS04510	COG2010	Cytochrome c
MTO99_RS04515	COG1845	cytochrome c oxidase, subunit III
MTO99_RS04520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MTO99_RS04525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MTO99_RS04530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MTO99_RS04535	COG2376	Dihydroxyacetone kinase
MTO99_RS04540	COG1461	Dihydroxyacetone kinase
MTO99_RS04585	COG0640	Transcriptional regulator
MTO99_RS04605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MTO99_RS04615	COG1414	Transcriptional regulator
MTO99_RS04620	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS04625	COG1129	ABC transporter
MTO99_RS04630	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS04635	COG4213	ABC transporter substrate-binding protein
MTO99_RS04650	COG1414	Transcriptional regulator
MTO99_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS04695	COG0584	glycerophosphoryl diester phosphodiesterase
MTO99_RS04710	COG4581	dead DEAH box helicase
MTO99_RS04715	COG0805	protein transport
MTO99_RS04720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTO99_RS04745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTO99_RS04755	COG1968	undecaprenyl-diphosphatase activity
MTO99_RS04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTO99_RS04790	COG0587	DNA-directed DNA polymerase activity
MTO99_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS04815	COG1113	amino acid transport
MTO99_RS04860	COG0438	transferase activity, transferring glycosyl groups
MTO99_RS04865	COG2267	carboxylic ester hydrolase activity
MTO99_RS04875	COG0254	rRNA binding
MTO99_RS04880	COG1119	ATPase activity
MTO99_RS04885	COG0297	glycogen (starch) synthase activity
MTO99_RS04890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MTO99_RS04895	COG0560	Phosphoserine phosphatase
MTO99_RS04895	COG3830	Belongs to the UPF0237 family
MTO99_RS04900	COG0667	Aldo Keto reductase
MTO99_RS04925	COG0488	(ABC) transporter
MTO99_RS04930	COG2353	YceI-like domain
MTO99_RS04935	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS04985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MTO99_RS05000	COG0799	negative regulation of ribosome biogenesis
MTO99_RS05010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MTO99_RS05020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MTO99_RS05025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MTO99_RS05030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MTO99_RS05035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MTO99_RS05040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MTO99_RS05050	COG1530	ribonuclease E activity
MTO99_RS05060	COG0105	UTP biosynthetic process
MTO99_RS05070	COG0285	dihydrofolate synthase activity
MTO99_RS05075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MTO99_RS05090	COG0747	negative chemotaxis
MTO99_RS05105	COG4172	Belongs to the ABC transporter superfamily
MTO99_RS05110	COG0525	valine-tRNA ligase activity
MTO99_RS05125	COG4106	trans-aconitate 2-methyltransferase activity
MTO99_RS05130	COG2151	metal-sulfur cluster biosynthetic enzyme
MTO99_RS05135	COG0396	ATPase activity
MTO99_RS05155	COG1612	heme a metabolic process
MTO99_RS05160	COG0109	protoheme IX farnesyltransferase activity
MTO99_RS05170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTO99_RS05175	COG0166	Belongs to the GPI family
MTO99_RS05190	COG0363	glucosamine-6-phosphate deaminase activity
MTO99_RS05200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTO99_RS05205	COG0149	triose-phosphate isomerase activity
MTO99_RS05210	COG0126	phosphoglycerate kinase activity
MTO99_RS05220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MTO99_RS05225	COG1481	regulation of sporulation
MTO99_RS05230	COG1660	Displays ATPase and GTPase activities
MTO99_RS05235	COG0322	excinuclease ABC activity
MTO99_RS05245	COG0556	nucleotide-excision repair
MTO99_RS05250	COG0237	dephospho-CoA kinase activity
MTO99_RS05260	COG0539	negative regulation of cytoplasmic translation
MTO99_RS05300	COG0067	glutamate synthase
MTO99_RS05300	COG0069	glutamate synthase activity
MTO99_RS05300	COG0070	glutamate synthase
MTO99_RS05305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MTO99_RS05310	COG0159	tryptophan synthase activity
MTO99_RS05315	COG0133	tryptophan synthase activity
MTO99_RS05320	COG0134	indole-3-glycerol-phosphate synthase activity
MTO99_RS05340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MTO99_RS05345	COG0107	imidazoleglycerol-phosphate synthase activity
MTO99_RS05350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MTO99_RS05355	COG0140	phosphoribosyl-ATP diphosphatase activity
MTO99_RS05360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MTO99_RS05370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MTO99_RS05380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MTO99_RS05390	COG1758	RNA polymerase activity
MTO99_RS05395	COG0194	GDP metabolic process
MTO99_RS05405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MTO99_RS05410	COG0505	Belongs to the CarA family
MTO99_RS05420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTO99_RS05425	COG0540	Belongs to the ATCase OTCase family
MTO99_RS05430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MTO99_RS05435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTO99_RS05440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MTO99_RS05445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MTO99_RS05450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MTO99_RS05455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTO99_RS05460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MTO99_RS05465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MTO99_RS05475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MTO99_RS05480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MTO99_RS05490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MTO99_RS05505	COG1196	nuclear chromosome segregation
MTO99_RS05515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTO99_RS05520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO99_RS05525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MTO99_RS05535	COG2255	four-way junction helicase activity
MTO99_RS05540	COG0632	four-way junction helicase activity
MTO99_RS05545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MTO99_RS05550	COG0217	transcriptional regulatory protein
MTO99_RS05565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MTO99_RS05570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MTO99_RS05580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MTO99_RS05590	COG4585	Histidine kinase
MTO99_RS05595	COG2197	response regulator
MTO99_RS05605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MTO99_RS05690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MTO99_RS05695	COG0183	Belongs to the thiolase family
MTO99_RS05700	COG1024	Enoyl-CoA hydratase
MTO99_RS05700	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTO99_RS05715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MTO99_RS05720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MTO99_RS05735	COG0756	dUTP diphosphatase activity
MTO99_RS05760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MTO99_RS05765	COG0740	serine-type endopeptidase activity
MTO99_RS05770	COG0740	serine-type endopeptidase activity
MTO99_RS05780	COG0544	peptidyl-prolyl cis-trans isomerase activity
MTO99_RS05850	COG4974	Belongs to the 'phage' integrase family
MTO99_RS05860	COG2376	Dihydroxyacetone kinase
MTO99_RS05870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTO99_RS05880	COG4585	Histidine kinase
MTO99_RS05885	COG0783	Belongs to the Dps family
MTO99_RS05890	COG2197	response regulator
MTO99_RS05900	COG2132	Multicopper oxidase
MTO99_RS05905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MTO99_RS05940	COG4585	Histidine kinase
MTO99_RS05945	COG2197	response regulator
MTO99_RS05955	COG0668	transmembrane transport
MTO99_RS05975	COG1946	Acyl-CoA thioesterase
MTO99_RS06005	COG0629	single-stranded DNA binding
MTO99_RS06010	COG0667	Aldo Keto reductase
MTO99_RS06025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MTO99_RS06035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MTO99_RS06060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MTO99_RS06060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MTO99_RS06070	COG4172	Belongs to the ABC transporter superfamily
MTO99_RS06075	COG4721	ABC-type cobalt transport system, permease component
MTO99_RS06085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MTO99_RS06090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MTO99_RS06095	COG0154	amidase activity
MTO99_RS06100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MTO99_RS06110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MTO99_RS06115	COG0482	sulfurtransferase activity
MTO99_RS06135	COG0058	SHG alpha-glucan phosphorylase activity
MTO99_RS06140	COG0366	Alpha amylase catalytic
MTO99_RS06145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MTO99_RS06195	COG0233	cytoplasmic translational termination
MTO99_RS06200	COG0528	UMP kinase activity
MTO99_RS06205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MTO99_RS06210	COG0052	Belongs to the universal ribosomal protein uS2 family
MTO99_RS06240	COG0792	nuclease activity
MTO99_RS06250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MTO99_RS06255	COG0681	Belongs to the peptidase S26 family
MTO99_RS06260	COG0335	large ribosomal subunit rRNA binding
MTO99_RS06270	COG0024	Methionine aminopeptidase
MTO99_RS06280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTO99_RS06280	COG2146	nitrite reductase [NAD(P)H] activity
MTO99_RS06285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTO99_RS06285	COG1648	precorrin-2 dehydrogenase activity
MTO99_RS06295	COG2223	nitrite transmembrane transporter activity
MTO99_RS06300	COG0243	molybdopterin cofactor binding
MTO99_RS06315	COG0336	Belongs to the RNA methyltransferase TrmD family
MTO99_RS06320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MTO99_RS06325	COG1837	Belongs to the UPF0109 family
MTO99_RS06330	COG0228	four-way junction DNA binding
MTO99_RS06335	COG3938	Belongs to the proline racemase family
MTO99_RS06340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTO99_RS06355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTO99_RS06360	COG1802	Transcriptional regulator
MTO99_RS06365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTO99_RS06395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MTO99_RS06430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTO99_RS06440	COG0571	ribonuclease III activity
MTO99_RS06445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MTO99_RS06465	COG0714	Associated with various cellular activities
MTO99_RS06470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MTO99_RS06475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MTO99_RS06485	COG0742	ribosomal rna small subunit methyltransferase
MTO99_RS06500	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTO99_RS06505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MTO99_RS06510	COG0204	Acyl-transferase
MTO99_RS06510	COG0318	PFAM AMP-dependent synthetase and ligase
MTO99_RS06515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MTO99_RS06520	COG0066	3-isopropylmalate dehydratase activity
MTO99_RS06525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MTO99_RS06545	COG0714	Associated with various cellular activities
MTO99_RS06560	COG0515	serine threonine protein kinase
MTO99_RS06560	COG2815	serine threonine protein kinase
MTO99_RS06570	COG0631	protein serine/threonine phosphatase activity
MTO99_RS06605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTO99_RS06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MTO99_RS06665	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTO99_RS06675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTO99_RS06680	COG0473	3-isopropylmalate dehydrogenase activity
MTO99_RS06710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MTO99_RS06715	COG0440	acetolactate synthase activity
MTO99_RS06720	COG0028	Belongs to the TPP enzyme family
MTO99_RS06725	COG0129	dihydroxy-acid dehydratase activity
MTO99_RS06730	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MTO99_RS06735	COG1511	domain protein
MTO99_RS06760	COG1268	BioY protein
MTO99_RS06765	COG1122	ATPase activity
MTO99_RS06770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MTO99_RS06970	COG0305	Participates in initiation and elongation during chromosome replication
MTO99_RS07115	COG0483	inositol monophosphate 1-phosphatase activity
MTO99_RS07165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MTO99_RS07170	COG2177	Part of the ABC transporter FtsEX involved in
MTO99_RS07175	COG2884	Cell division ATP-binding protein ftsE
MTO99_RS07185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MTO99_RS07250	COG0586	Pfam SNARE associated Golgi protein
MTO99_RS07260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MTO99_RS07265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MTO99_RS07270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MTO99_RS07295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MTO99_RS07330	COG0210	DNA helicase
MTO99_RS07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTO99_RS07390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTO99_RS07395	COG0596	Alpha beta hydrolase
MTO99_RS07400	COG3973	AAA domain
MTO99_RS07455	COG4941	Belongs to the sigma-70 factor family
MTO99_RS07560	COG1615	UPF0182 protein
MTO99_RS07565	COG3480	Lon protease (S16) C-terminal proteolytic domain
MTO99_RS07615	COG0513	Belongs to the DEAD box helicase family
MTO99_RS07620	COG0613	PHP domain protein
MTO99_RS07630	COG0006	proline dipeptidase activity
MTO99_RS07650	COG2239	Acts as a magnesium transporter
MTO99_RS07680	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS07685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTO99_RS07705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTO99_RS07725	COG2171	N-acyltransferase activity
MTO99_RS07760	COG1024	Enoyl-CoA hydratase
MTO99_RS07765	COG0739	heme binding
MTO99_RS07770	COG1217	gtp-binding protein TYPA
MTO99_RS07780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS07790	COG4166	transmembrane transport
MTO99_RS07805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MTO99_RS07805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MTO99_RS07810	COG0509	glycine decarboxylation via glycine cleavage system
MTO99_RS07815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MTO99_RS07825	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MTO99_RS07830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MTO99_RS07840	COG1104	cysteine desulfurase activity
MTO99_RS07845	COG2814	Major facilitator Superfamily
MTO99_RS07860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTO99_RS07890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTO99_RS07950	COG2207	Transcriptional regulator
MTO99_RS07950	COG3708	Transcriptional regulator
MTO99_RS07965	COG0012	GTP binding
MTO99_RS08025	COG0191	fructose-bisphosphate aldolase activity
MTO99_RS08050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MTO99_RS08055	COG1570	exodeoxyribonuclease VII activity
MTO99_RS08060	COG1722	exodeoxyribonuclease VII activity
MTO99_RS08075	COG0114	fumarate hydratase activity
MTO99_RS08095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MTO99_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MTO99_RS08125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTO99_RS08130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MTO99_RS08140	COG3214	Protein conserved in bacteria
MTO99_RS08145	COG0501	Belongs to the peptidase M48B family
MTO99_RS08150	COG1704	LemA family
MTO99_RS08165	COG2211	Major facilitator Superfamily
MTO99_RS08175	COG0248	Ppx GppA phosphatase
MTO99_RS08205	COG0148	phosphopyruvate hydratase activity
MTO99_RS08215	COG0124	histidyl-tRNA synthetase
MTO99_RS08240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MTO99_RS08255	COG0328	RNA-DNA hybrid ribonuclease activity
MTO99_RS08270	COG0193	aminoacyl-tRNA hydrolase activity
MTO99_RS08295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MTO99_RS08300	COG0800	Aldolase
MTO99_RS08310	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS08315	COG3265	gluconokinase activity
MTO99_RS08320	COG0246	Mannitol dehydrogenase
MTO99_RS08330	COG0673	inositol 2-dehydrogenase activity
MTO99_RS08340	COG1609	Transcriptional regulator
MTO99_RS08345	COG1904	glucuronate isomerase
MTO99_RS08355	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS08380	COG3386	PFAM SMP-30 Gluconolaconase
MTO99_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS08395	COG0673	inositol 2-dehydrogenase activity
MTO99_RS08405	COG1063	alcohol dehydrogenase
MTO99_RS08415	COG2022	thiamine diphosphate biosynthetic process
MTO99_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS08435	COG0473	3-isopropylmalate dehydrogenase activity
MTO99_RS08440	COG1349	DNA-binding transcription factor activity
MTO99_RS08445	COG3684	Belongs to the aldolase LacD family
MTO99_RS08450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO99_RS08455	COG0395	ABC-type sugar transport system, permease component
MTO99_RS08465	COG1653	transport
MTO99_RS08475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MTO99_RS08490	COG0318	PFAM AMP-dependent synthetase and ligase
MTO99_RS08495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MTO99_RS08500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MTO99_RS08520	COG1403	HNH endonuclease
MTO99_RS08535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MTO99_RS08555	COG0488	(ABC) transporter
MTO99_RS08560	COG0490	domain, Protein
MTO99_RS08560	COG0471	metal ion transport
MTO99_RS08565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MTO99_RS08570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MTO99_RS08575	COG0084	hydrolase, TatD family'
MTO99_RS08580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTO99_RS08600	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
MTO99_RS08615	COG1476	TRANSCRIPTIONal
MTO99_RS08625	COG2076	Multidrug Resistance protein
MTO99_RS08630	COG1335	isochorismatase
MTO99_RS08640	COG2197	response regulator
MTO99_RS08645	COG4585	Histidine kinase
MTO99_RS08665	COG1832	CoA-binding protein
MTO99_RS08695	COG1760	l-serine dehydratase
MTO99_RS08710	COG1362	aminopeptidase activity
MTO99_RS08715	COG0484	heat shock protein binding
MTO99_RS08740	COG1331	Highly conserved protein containing a thioredoxin domain
MTO99_RS08765	COG1643	Atp-dependent helicase
MTO99_RS08775	COG0640	Transcriptional regulator
MTO99_RS08785	COG0656	L-ascorbic acid biosynthetic process
MTO99_RS08820	COG0475	glutathione-regulated potassium exporter activity
MTO99_RS08840	COG1120	ATPase activity
MTO99_RS08845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS08850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS08875	COG0583	DNA-binding transcription factor activity
MTO99_RS08900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MTO99_RS08915	COG1970	mechanosensitive ion channel activity
MTO99_RS08930	COG0686	Belongs to the AlaDH PNT family
MTO99_RS08935	COG1522	sequence-specific DNA binding
MTO99_RS08940	COG1793	dna ligase
MTO99_RS08960	COG0454	-acetyltransferase
MTO99_RS08975	COG1388	LysM domain
MTO99_RS08975	COG3942	CHAP domain
MTO99_RS08995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MTO99_RS09025	COG1061	Type III restriction enzyme res subunit
MTO99_RS09035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MTO99_RS09045	COG0745	RESPONSE REGULATOR receiver
MTO99_RS09050	COG2205	protein histidine kinase activity
MTO99_RS09065	COG0459	protein refolding
MTO99_RS09075	COG1278	Cold shock
MTO99_RS09090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTO99_RS09595	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
MTO99_RS09685	COG3842	ATPase activity
MTO99_RS09700	COG0215	cysteine-tRNA ligase activity
MTO99_RS09705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MTO99_RS09705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MTO99_RS09725	COG5002	protein histidine kinase activity
MTO99_RS09730	COG0704	Plays a role in the regulation of phosphate uptake
MTO99_RS09735	COG0588	phosphoglycerate mutase activity
MTO99_RS09750	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MTO99_RS09760	COG0745	RESPONSE REGULATOR receiver
MTO99_RS09765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MTO99_RS09770	COG0406	alpha-ribazole phosphatase activity
MTO99_RS09770	COG0494	nUDIX hydrolase
MTO99_RS09790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MTO99_RS09835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS09845	COG2017	converts alpha-aldose to the beta-anomer
MTO99_RS09850	COG1349	DNA-binding transcription factor activity
MTO99_RS09860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MTO99_RS09870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO99_RS09885	COG2089	acid synthase
MTO99_RS09890	COG0561	phosphatase activity
MTO99_RS09895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MTO99_RS09900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MTO99_RS09920	COG2814	Major facilitator Superfamily
MTO99_RS09950	COG1940	carbohydrate kinase activity
MTO99_RS09955	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS09960	COG0395	ABC-type sugar transport system, permease component
MTO99_RS09965	COG1175	transmembrane transport
MTO99_RS09975	COG1940	carbohydrate kinase activity
MTO99_RS09980	COG2217	Heavy metal translocating P-type atpase
MTO99_RS09985	COG0538	isocitrate dehydrogenase activity
MTO99_RS10005	COG2197	response regulator
MTO99_RS10010	COG1752	Esterase of the alpha-beta hydrolase superfamily
MTO99_RS10015	COG1132	(ABC) transporter
MTO99_RS10035	COG1136	(ABC) transporter
MTO99_RS10035	COG0577	efflux transmembrane transporter activity
MTO99_RS10040	COG1136	(ABC) transporter
MTO99_RS10045	COG1834	amidinotransferase
MTO99_RS10055	COG0138	bifunctional purine biosynthesis protein purh
MTO99_RS10085	COG0045	succinate-CoA ligase (ADP-forming) activity
MTO99_RS10095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTO99_RS10115	COG2211	Major facilitator Superfamily
MTO99_RS10130	COG0584	glycerophosphoryl diester phosphodiesterase
MTO99_RS10140	COG4941	Belongs to the sigma-70 factor family
MTO99_RS10150	COG0039	L-malate dehydrogenase activity
MTO99_RS10165	COG0519	Catalyzes the synthesis of GMP from XMP
MTO99_RS10165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MTO99_RS10185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MTO99_RS10190	COG0516	GMP reductase activity
MTO99_RS10205	COG0488	(ABC) transporter
MTO99_RS10225	COG0559	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS10255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MTO99_RS10280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MTO99_RS10285	COG0456	acetyltransferase
MTO99_RS10295	COG0802	atpase or kinase
MTO99_RS10300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MTO99_RS10305	COG0736	holo-[acyl-carrier-protein] synthase activity
MTO99_RS10310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MTO99_RS10315	COG1072	(Pantothenic acid kinase))
MTO99_RS10320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTO99_RS10325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MTO99_RS10330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MTO99_RS10335	COG0101	tRNA pseudouridine synthase activity
MTO99_RS10340	COG0203	ribosomal protein L17
MTO99_RS10345	COG0202	RNA polymerase activity
MTO99_RS10350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MTO99_RS10355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MTO99_RS10360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MTO99_RS10365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MTO99_RS10370	COG0246	Mannitol dehydrogenase
MTO99_RS10375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTO99_RS10385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MTO99_RS10405	COG0024	Methionine aminopeptidase
MTO99_RS10410	COG0563	adenylate kinase activity
MTO99_RS10420	COG0200	Binds to the 23S rRNA
MTO99_RS10425	COG1841	ribosomal large subunit assembly
MTO99_RS10430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MTO99_RS10435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MTO99_RS10440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MTO99_RS10445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MTO99_RS10450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MTO99_RS10455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MTO99_RS10460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MTO99_RS10465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MTO99_RS10475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MTO99_RS10480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MTO99_RS10485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MTO99_RS10490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MTO99_RS10495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MTO99_RS10500	COG0089	rRNA binding
MTO99_RS10505	COG0088	Forms part of the polypeptide exit tunnel
MTO99_RS10510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MTO99_RS10515	COG0051	transcription antitermination factor activity, RNA binding
MTO99_RS10530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MTO99_RS10535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTO99_RS10540	COG0049	tRNA binding
MTO99_RS10545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MTO99_RS10575	COG0135	phosphoribosylanthranilate isomerase activity
MTO99_RS10640	COG1674	ftsk spoiiie
MTO99_RS10665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MTO99_RS10670	COG0085	RNA polymerase activity
MTO99_RS10690	COG1984	allophanate hydrolase subunit 2
MTO99_RS10695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MTO99_RS10700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MTO99_RS10740	COG0513	Belongs to the DEAD box helicase family
MTO99_RS10745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTO99_RS10785	COG0519	Catalyzes the synthesis of GMP from XMP
MTO99_RS10825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MTO99_RS10845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MTO99_RS10865	COG3655	Transcriptional regulator
MTO99_RS10895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MTO99_RS10900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MTO99_RS10925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MTO99_RS10930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MTO99_RS10935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MTO99_RS10940	COG0302	gtp cyclohydrolase
MTO99_RS10945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTO99_RS10965	COG0037	tRNA processing
MTO99_RS10970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MTO99_RS11035	COG1725	Transcriptional regulator
MTO99_RS11105	COG0697	spore germination
MTO99_RS11110	COG0596	Alpha beta hydrolase
MTO99_RS11130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MTO99_RS11190	COG0438	transferase activity, transferring glycosyl groups
MTO99_RS11195	COG2755	lipolytic protein G-D-S-L family
MTO99_RS11195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MTO99_RS11205	COG1215	transferase activity, transferring glycosyl groups
MTO99_RS11210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MTO99_RS11215	COG0673	inositol 2-dehydrogenase activity
MTO99_RS11235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MTO99_RS11240	COG0736	holo-[acyl-carrier-protein] synthase activity
MTO99_RS11245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTO99_RS11255	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTO99_RS11265	COG0039	L-malate dehydrogenase activity
MTO99_RS11295	COG0514	ATP-dependent DNA helicase (RecQ)
MTO99_RS11300	COG2372	response to copper ion
MTO99_RS11315	COG0737	Belongs to the 5'-nucleotidase family
MTO99_RS11325	COG4581	dead DEAH box helicase
MTO99_RS11330	COG1309	transcriptional regulator
MTO99_RS11355	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MTO99_RS11380	COG0640	Transcriptional regulator
MTO99_RS11385	COG1966	Carbon starvation protein
MTO99_RS11405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MTO99_RS11410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTO99_RS11410	COG0730	response to heat
MTO99_RS11415	COG1278	Cold shock
MTO99_RS11440	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS11460	COG3845	ABC transporter
MTO99_RS11465	COG2814	Major facilitator Superfamily
MTO99_RS11475	COG0646	methionine synthase
MTO99_RS11475	COG1410	methionine synthase
MTO99_RS11500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTO99_RS11545	COG3328	transposase activity
MTO99_RS11555	COG1136	(ABC) transporter
MTO99_RS11600	COG0183	Belongs to the thiolase family
MTO99_RS11605	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS11625	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS11630	COG0318	PFAM AMP-dependent synthetase and ligase
MTO99_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS11655	COG4177	L-phenylalanine transmembrane transporter activity
MTO99_RS11665	COG0410	ABC transporter
MTO99_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS11700	COG0477	Major facilitator Superfamily
MTO99_RS11765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MTO99_RS11780	COG1090	epimerase
MTO99_RS11810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MTO99_RS11815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTO99_RS11830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MTO99_RS11890	COG2066	Belongs to the glutaminase family
MTO99_RS11890	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MTO99_RS11975	COG0494	nUDIX hydrolase
MTO99_RS11980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MTO99_RS11985	COG0456	acetyltransferase
MTO99_RS12015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MTO99_RS12015	COG0351	phosphomethylpyrimidine kinase
MTO99_RS12015	COG0352	thiamine-phosphate diphosphorylase activity
MTO99_RS12020	COG0477	Major facilitator Superfamily
MTO99_RS12035	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTO99_RS12045	COG0740	serine-type endopeptidase activity
MTO99_RS12050	COG0740	serine-type endopeptidase activity
MTO99_RS12055	COG1396	sequence-specific DNA binding
MTO99_RS12070	COG4977	sequence-specific DNA binding
MTO99_RS12090	COG0395	ABC-type sugar transport system, permease component
MTO99_RS12095	COG1175	transmembrane transport
MTO99_RS12100	COG1653	transport
MTO99_RS12115	COG1119	ATPase activity
MTO99_RS12120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTO99_RS12140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTO99_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS12195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS12215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS12240	COG1122	ATPase activity
MTO99_RS12245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MTO99_RS12250	COG0545	Peptidyl-prolyl cis-trans isomerase
MTO99_RS12255	COG2226	methyltransferase
MTO99_RS12260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MTO99_RS12260	COG2111	Na H antiporter
MTO99_RS12265	COG1006	Multisubunit Na H antiporter MnhC subunit
MTO99_RS12270	COG0651	ATP synthesis coupled electron transport
MTO99_RS12285	COG1320	monovalent cation:proton antiporter activity
MTO99_RS12300	COG0513	Belongs to the DEAD box helicase family
MTO99_RS12310	COG1295	ribonuclease BN
MTO99_RS12325	COG0739	heme binding
MTO99_RS12330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MTO99_RS12335	COG1228	amidohydrolase
MTO99_RS12340	COG3328	transposase activity
MTO99_RS12355	COG2871	sodium ion transport
MTO99_RS12360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MTO99_RS12370	COG0010	Belongs to the arginase family
MTO99_RS12375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MTO99_RS12380	COG2217	Heavy metal translocating P-type atpase
MTO99_RS12385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO99_RS12390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTO99_RS12420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO99_RS12425	COG2364	Membrane
MTO99_RS12470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MTO99_RS12490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTO99_RS12530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS12535	COG1120	ATPase activity
MTO99_RS12545	COG0151	Belongs to the GarS family
MTO99_RS12550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MTO99_RS12555	COG2514	catechol 2,3-dioxygenase activity
MTO99_RS12565	COG3483	tryptophan 2,3-dioxygenase activity
MTO99_RS12590	COG1403	HNH endonuclease
MTO99_RS12595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTO99_RS12600	COG0047	phosphoribosylformylglycinamidine synthase activity
MTO99_RS12615	COG0579	oxidoreductase
MTO99_RS12640	COG0318	PFAM AMP-dependent synthetase and ligase
MTO99_RS12645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MTO99_RS12655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTO99_RS12680	COG3250	beta-galactosidase activity
MTO99_RS12685	COG4608	Belongs to the ABC transporter superfamily
MTO99_RS12690	COG0444	Belongs to the ABC transporter superfamily
MTO99_RS12695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS12700	COG0601	transmembrane transport
MTO99_RS12705	COG0747	negative chemotaxis
MTO99_RS12760	COG0287	Prephenate dehydrogenase
MTO99_RS12760	COG1605	Chorismate mutase
MTO99_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
MTO99_RS12770	COG1309	transcriptional regulator
MTO99_RS12795	COG0183	Belongs to the thiolase family
MTO99_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS12825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MTO99_RS12835	COG2079	MmgE PrpD family protein
MTO99_RS12840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTO99_RS12860	COG1131	(ABC) transporter
MTO99_RS12865	COG1725	Transcriptional regulator
MTO99_RS12890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MTO99_RS12940	COG0582	viral genome integration into host DNA
MTO99_RS12950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTO99_RS12960	COG3275	phosphorelay sensor kinase activity
MTO99_RS12965	COG3279	Response regulator of the LytR AlgR family
MTO99_RS12975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTO99_RS12985	COG3328	transposase activity
MTO99_RS13010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MTO99_RS13020	COG0137	argininosuccinate synthase activity
MTO99_RS13080	COG2936	dipeptidyl-peptidase activity
MTO99_RS13120	COG0667	Aldo Keto reductase
MTO99_RS13150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS13155	COG0601	transmembrane transport
MTO99_RS13170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MTO99_RS13170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MTO99_RS13180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MTO99_RS13190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MTO99_RS13195	COG3340	Belongs to the peptidase S51 family
MTO99_RS13210	COG2409	Drug exporters of the RND superfamily
MTO99_RS13230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTO99_RS13235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MTO99_RS13245	COG1116	anion transmembrane transporter activity
MTO99_RS13250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTO99_RS13260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTO99_RS13270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO99_RS13280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MTO99_RS13290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MTO99_RS13300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS13305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MTO99_RS13365	COG4916	TIR domain
MTO99_RS13395	COG1136	(ABC) transporter
MTO99_RS13425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS13430	COG1920	GTP binding
MTO99_RS13435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS13440	COG0778	Nitroreductase
MTO99_RS13440	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MTO99_RS13455	COG2197	response regulator
MTO99_RS13460	COG4585	Histidine kinase
MTO99_RS13470	COG0300	oxidoreductase activity
MTO99_RS13475	COG1116	anion transmembrane transporter activity
MTO99_RS13485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTO99_RS13515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTO99_RS13520	COG0726	polysaccharide deacetylase
MTO99_RS13565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTO99_RS13595	COG2197	response regulator
MTO99_RS13605	COG0662	Cupin 2, conserved barrel domain protein
MTO99_RS13615	COG4152	abc transporter atp-binding protein
MTO99_RS13645	COG0477	Major facilitator Superfamily
MTO99_RS13655	COG0542	response to heat
MTO99_RS13660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS13675	COG1120	ATPase activity
MTO99_RS13680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS13685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTO99_RS13690	COG4592	Periplasmic binding protein
MTO99_RS13705	COG2365	Tyrosine phosphatase family
MTO99_RS13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTO99_RS13720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTO99_RS13750	COG0477	Major facilitator Superfamily
MTO99_RS13755	COG0628	permease
MTO99_RS13760	COG0628	permease
MTO99_RS13780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MTO99_RS13785	COG2813	Specifically methylates the guanine in position
MTO99_RS13810	COG0789	Transcriptional regulator
MTO99_RS13815	COG0484	heat shock protein binding
MTO99_RS13820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MTO99_RS13825	COG0443	Heat shock 70 kDa protein
MTO99_RS13840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTO99_RS13845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTO99_RS13850	COG0659	secondary active sulfate transmembrane transporter activity
MTO99_RS13890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTO99_RS13895	COG0175	sulfate reduction
MTO99_RS13915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MTO99_RS13925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MTO99_RS13925	COG1648	precorrin-2 dehydrogenase activity
MTO99_RS13940	COG1063	alcohol dehydrogenase
MTO99_RS13945	COG0444	Belongs to the ABC transporter superfamily
MTO99_RS13950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS13955	COG0601	transmembrane transport
MTO99_RS13960	COG4608	Belongs to the ABC transporter superfamily
MTO99_RS14020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTO99_RS14020	COG2308	Evidence 4 Homologs of previously reported genes of
MTO99_RS14025	COG1058	Belongs to the CinA family
MTO99_RS14025	COG1546	Belongs to the CinA family
MTO99_RS14040	COG0717	Belongs to the dCTP deaminase family
MTO99_RS14080	COG1129	ABC transporter
MTO99_RS14100	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTO99_RS14130	COG0251	oxidation-reduction process
MTO99_RS14135	COG0598	Magnesium transport protein CorA
MTO99_RS14150	COG2197	response regulator
MTO99_RS14150	COG3903	Transcriptional regulator
MTO99_RS14180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MTO99_RS14190	COG3336	cytochrome c oxidase
MTO99_RS14195	COG0776	regulation of translation
MTO99_RS14200	COG2235	arginine
MTO99_RS14215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MTO99_RS14220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MTO99_RS14225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MTO99_RS14230	COG0076	glutamate decarboxylase activity
MTO99_RS14250	COG1121	(ABC) transporter
MTO99_RS14255	COG0803	Belongs to the bacterial solute-binding protein 9 family
MTO99_RS14265	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO99_RS14270	COG0022	dehydrogenase e1 component
MTO99_RS14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTO99_RS14285	COG1950	PFAM Membrane protein of
MTO99_RS14305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTO99_RS14310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MTO99_RS14335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTO99_RS14345	COG0747	negative chemotaxis
MTO99_RS14355	COG1132	(ABC) transporter
MTO99_RS14360	COG1132	(ABC) transporter
MTO99_RS14365	COG0640	Transcriptional regulator
MTO99_RS14385	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MTO99_RS14415	COG0534	Mate efflux family protein
MTO99_RS14440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTO99_RS14450	COG0596	Alpha beta hydrolase
MTO99_RS14490	COG0305	Participates in initiation and elongation during chromosome replication
MTO99_RS14495	COG0359	binds to the 23S rRNA
MTO99_RS14500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MTO99_RS14510	COG0360	Binds together with S18 to 16S ribosomal RNA
MTO99_RS14530	COG0617	tRNA 3'-terminal CCA addition
MTO99_RS14545	COG0492	ferredoxin-NADP+ reductase activity
MTO99_RS14550	COG3118	belongs to the thioredoxin family
MTO99_RS14555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO99_RS14560	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTO99_RS14570	COG1192	Involved in chromosome partitioning
MTO99_RS14575	COG0357	Ribosomal RNA small subunit methyltransferase G
MTO99_RS14585	COG0706	membrane insertase activity
MTO99_RS14590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MTO99_RS14595	COG0594	ribonuclease P activity
MTO99_RS14600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MTO99_RS14605	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MTO99_RS14610	COG0592	DNA-directed DNA polymerase activity
MTO99_RS14615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MTO99_RS14620	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MTO99_RS14625	COG0187	DNA topoisomerase II activity
MTO99_RS14630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MTO99_RS14665	COG3534	alpha-L-arabinofuranosidase
MTO99_RS14670	COG1609	Transcriptional regulator
MTO99_RS14680	COG4209	transmembrane transport
MTO99_RS14685	COG0395	ABC-type sugar transport system, permease component
MTO99_RS14700	COG0657	acetylesterase activity
MTO99_RS14730	COG0494	nUDIX hydrolase
MTO99_RS14750	COG0457	Tetratricopeptide repeat
MTO99_RS14750	COG0705	Rhomboid family
MTO99_RS14760	COG3764	Sortase (surface protein transpeptidase)
MTO99_RS14775	COG2815	serine threonine protein kinase
MTO99_RS14775	COG0515	serine threonine protein kinase
MTO99_RS14780	COG0515	serine threonine protein kinase
MTO99_RS14785	COG0768	penicillin binding
MTO99_RS14800	COG1716	ATPase activity
MTO99_RS14805	COG1716	ATPase activity
MTO99_RS14840	COG1252	NADH dehydrogenase
MTO99_RS14845	COG0477	Major facilitator Superfamily
MTO99_RS14850	COG0183	Belongs to the thiolase family
MTO99_RS14860	COG1024	Enoyl-CoA hydratase
MTO99_RS14865	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTO99_RS14870	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS14870	COG2030	dehydratase
MTO99_RS14875	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MTO99_RS14885	COG0514	ATP-dependent DNA helicase (RecQ)
MTO99_RS14890	COG1309	transcriptional regulator
MTO99_RS14895	COG5297	Belongs to the glycosyl hydrolase family 6
MTO99_RS14895	COG3250	beta-galactosidase activity
MTO99_RS14915	COG3396	Phenylacetate-CoA oxygenase
MTO99_RS14920	COG3460	Phenylacetate-CoA oxygenase
MTO99_RS14925	COG3396	Phenylacetate-CoA oxygenase
MTO99_RS14930	COG2151	metal-sulfur cluster biosynthetic enzyme
MTO99_RS14935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MTO99_RS14940	COG0246	Mannitol dehydrogenase
MTO99_RS14945	COG3458	cephalosporin-C deacetylase activity
MTO99_RS14950	COG4209	transmembrane transport
MTO99_RS14955	COG0395	ABC-type sugar transport system, permease component
MTO99_RS14975	COG1904	glucuronate isomerase
MTO99_RS14980	COG1609	Transcriptional regulator
MTO99_RS15015	COG1597	lipid kinase activity
MTO99_RS15045	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS15055	COG1793	dna ligase
MTO99_RS15055	COG3285	dna ligase
MTO99_RS15065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MTO99_RS15070	COG0076	glutamate decarboxylase activity
MTO99_RS15075	COG1063	alcohol dehydrogenase
MTO99_RS15085	COG0129	dihydroxy-acid dehydratase activity
MTO99_RS15095	COG2409	Drug exporters of the RND superfamily
MTO99_RS15115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MTO99_RS15120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTO99_RS15130	COG3152	Membrane
MTO99_RS15135	COG3458	cephalosporin-C deacetylase activity
MTO99_RS15145	COG0277	FAD linked oxidase domain protein
MTO99_RS15175	COG1864	DNA RNA non-specific endonuclease
MTO99_RS15175	COG3591	Belongs to the peptidase S1B family
MTO99_RS15225	COG0673	inositol 2-dehydrogenase activity
MTO99_RS15235	COG1175	transmembrane transport
MTO99_RS15240	COG0395	ABC-type sugar transport system, permease component
MTO99_RS15245	COG3842	ATPase activity
MTO99_RS15260	COG2188	Transcriptional regulator
MTO99_RS15270	COG3962	Belongs to the TPP enzyme family
MTO99_RS15305	COG2837	iron assimilation
MTO99_RS15320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTO99_RS15325	COG0477	Major facilitator Superfamily
MTO99_RS15345	COG0386	Belongs to the glutathione peroxidase family
MTO99_RS15360	COG2195	Cleaves the N-terminal amino acid of tripeptides
MTO99_RS15380	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MTO99_RS15390	COG0738	Major facilitator superfamily
MTO99_RS15395	COG1063	alcohol dehydrogenase
MTO99_RS15400	COG0156	8-amino-7-oxononanoate synthase activity
MTO99_RS15420	COG0534	Mate efflux family protein
MTO99_RS15425	COG3304	Inner membrane component domain
MTO99_RS15430	COG3590	peptidase
MTO99_RS15460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MTO99_RS15465	COG0423	glycine-tRNA ligase activity
MTO99_RS15475	COG0519	Catalyzes the synthesis of GMP from XMP
MTO99_RS15480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MTO99_RS15495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MTO99_RS15560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MTO99_RS15565	COG0181	hydroxymethylbilane synthase activity
MTO99_RS15575	COG0113	porphobilinogen synthase activity
MTO99_RS15580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MTO99_RS15605	COG1131	(ABC) transporter
MTO99_RS15625	COG3226	Transcriptional regulator
MTO99_RS15645	COG1054	Belongs to the UPF0176 family
MTO99_RS15665	COG0822	iron-sulfur transferase activity
MTO99_RS15675	COG2079	MmgE PrpD family protein
MTO99_RS15680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTO99_RS15690	COG2197	response regulator
MTO99_RS15720	COG1309	transcriptional regulator
MTO99_RS15725	COG0477	Major facilitator Superfamily
MTO99_RS15775	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS15780	COG2205	protein histidine kinase activity
MTO99_RS15785	COG0745	RESPONSE REGULATOR receiver
MTO99_RS15800	COG0577	efflux transmembrane transporter activity
MTO99_RS15800	COG1136	(ABC) transporter
MTO99_RS15805	COG0577	efflux transmembrane transporter activity
MTO99_RS15805	COG1136	(ABC) transporter
MTO99_RS15810	COG0189	ligase activity
MTO99_RS15810	COG4067	protein conserved in archaea
MTO99_RS15815	COG0189	ligase activity
MTO99_RS15815	COG0569	domain protein
MTO99_RS15820	COG1725	Transcriptional regulator
MTO99_RS15845	COG2205	protein histidine kinase activity
MTO99_RS15850	COG0745	RESPONSE REGULATOR receiver
MTO99_RS15875	COG3104	oligopeptide transport
MTO99_RS15880	COG1216	Glycosyl transferase, family 2
MTO99_RS15885	COG1472	Belongs to the glycosyl hydrolase 3 family
MTO99_RS15895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MTO99_RS15930	COG2186	Transcriptional regulator
MTO99_RS15935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MTO99_RS15950	COG0693	protein deglycase activity
MTO99_RS15960	COG0667	Aldo Keto reductase
MTO99_RS15965	COG3842	ATPase activity
MTO99_RS15985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MTO99_RS16025	COG1609	Transcriptional regulator
MTO99_RS16030	COG1175	transmembrane transport
MTO99_RS16035	COG0395	ABC-type sugar transport system, permease component
MTO99_RS16040	COG0673	inositol 2-dehydrogenase activity
MTO99_RS16060	COG1070	Carbohydrate kinase
MTO99_RS16065	COG3347	Dehydrogenase
MTO99_RS16065	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS16075	COG3254	rhamnose metabolic process
MTO99_RS16095	COG1129	ABC transporter
MTO99_RS16100	COG1609	Transcriptional regulator
MTO99_RS16125	COG1305	Transglutaminase-like
MTO99_RS16155	COG0095	Lipoate-protein ligase
MTO99_RS16170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MTO99_RS16195	COG1175	transmembrane transport
MTO99_RS16205	COG1876	peptidase activity
MTO99_RS16210	COG0477	Major facilitator Superfamily
MTO99_RS16230	COG2733	membrane
MTO99_RS16235	COG0077	Prephenate dehydratase
MTO99_RS16240	COG2182	Extracellular solute-binding protein
MTO99_RS16245	COG1175	transmembrane transport
MTO99_RS16250	COG0395	ABC-type sugar transport system, permease component
MTO99_RS16255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MTO99_RS16260	COG1940	carbohydrate kinase activity
MTO99_RS16275	COG1597	lipid kinase activity
MTO99_RS16280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MTO99_RS16285	COG0561	phosphatase activity
MTO99_RS16295	COG1316	TRANSCRIPTIONal
MTO99_RS16310	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS16315	COG0390	transport system, permease component
MTO99_RS16330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MTO99_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS16370	COG1609	Transcriptional regulator
MTO99_RS16375	COG0366	Alpha amylase catalytic
MTO99_RS16390	COG0395	ABC-type sugar transport system, permease component
MTO99_RS16515	COG4974	Belongs to the 'phage' integrase family
MTO99_RS16545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MTO99_RS16555	COG0505	Belongs to the CarA family
MTO99_RS16560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MTO99_RS16565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MTO99_RS16570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MTO99_RS16585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MTO99_RS16610	COG1131	(ABC) transporter
MTO99_RS16615	COG0569	domain protein
MTO99_RS16620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MTO99_RS16645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MTO99_RS16650	COG0017	Asparaginyl-tRNA synthetase
MTO99_RS16660	COG0406	alpha-ribazole phosphatase activity
MTO99_RS16665	COG3118	belongs to the thioredoxin family
MTO99_RS16670	COG0785	Cytochrome C biogenesis protein
MTO99_RS16675	COG1333	cytochrome c biogenesis protein
MTO99_RS16680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MTO99_RS16700	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS16710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MTO99_RS16715	COG1028	Short-chain dehydrogenase reductase Sdr
MTO99_RS16745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MTO99_RS16750	COG2326	polyphosphate kinase activity
MTO99_RS16770	COG2226	methyltransferase
MTO99_RS16775	COG0142	geranyltranstransferase activity
MTO99_RS16800	COG1666	GTP binding
MTO99_RS16805	COG1609	Transcriptional regulator
MTO99_RS16825	COG0366	Alpha amylase catalytic
MTO99_RS16830	COG1609	Transcriptional regulator
MTO99_RS16875	COG0739	heme binding
MTO99_RS16880	COG0366	Alpha amylase catalytic
MTO99_RS16885	COG2182	Extracellular solute-binding protein
MTO99_RS16900	COG0366	Alpha amylase catalytic
MTO99_RS16915	COG2197	response regulator
MTO99_RS16930	COG1222	aaa ATPase
MTO99_RS17025	COG3328	transposase activity
MTO99_RS17050	COG3328	transposase activity
MTO99_RS17055	COG2197	response regulator
MTO99_RS17080	COG3409	Peptidoglycan-binding domain 1 protein
MTO99_RS17090	COG3328	transposase activity
MTO99_RS17100	COG3328	transposase activity
MTO99_RS17170	COG1129	ABC transporter
MTO99_RS17170	COG0842	Transport permease protein
MTO99_RS17175	COG0842	Transport permease protein
MTO99_RS17180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTO99_RS17245	COG2197	response regulator
MTO99_RS17250	COG2030	dehydratase
MTO99_RS17260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MTO99_RS17265	COG1136	(ABC) transporter
MTO99_RS17275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MTO99_RS17280	COG2197	response regulator
MTO99_RS17295	COG1131	(ABC) transporter
MTO99_RS17300	COG4941	Belongs to the sigma-70 factor family
MTO99_RS17325	COG0583	DNA-binding transcription factor activity
MTO99_RS17330	COG3237	CsbD-like
MTO99_RS17335	COG1063	alcohol dehydrogenase
MTO99_RS17345	COG0436	Aminotransferase
MTO99_RS17360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MTO99_RS17365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MTO99_RS17370	COG3833	ABC-type maltose transport systems, permease component
MTO99_RS17375	COG1175	transmembrane transport
MTO99_RS17410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MTO99_RS17415	COG0081	regulation of translation
MTO99_RS17420	COG1254	Belongs to the acylphosphatase family
MTO99_RS17435	COG1254	Belongs to the acylphosphatase family
MTO99_RS17440	COG1012	belongs to the aldehyde dehydrogenase family
MTO99_RS17470	COG1733	regulation of RNA biosynthetic process
MTO99_RS17480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTO99_RS17490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MTO99_RS17520	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTO99_RS17520	COG0596	Alpha beta hydrolase
MTO99_RS17530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MTO99_RS17615	COG1674	ftsk spoiiie
MTO99_RS17640	COG0714	Associated with various cellular activities
MTO99_RS17660	COG0631	protein serine/threonine phosphatase activity
MTO99_RS17680	COG0604	alcohol dehydrogenase
MTO99_RS17700	COG0673	inositol 2-dehydrogenase activity
MTO99_RS17705	COG1129	ABC transporter
MTO99_RS17710	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS17715	COG4211	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS17740	COG1136	(ABC) transporter
MTO99_RS17750	COG0745	RESPONSE REGULATOR receiver
MTO99_RS17755	COG2205	protein histidine kinase activity
MTO99_RS17770	COG0477	Major facilitator Superfamily
MTO99_RS17775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MTO99_RS17780	COG0222	ribosome binding
MTO99_RS17790	COG2814	Major facilitator Superfamily
MTO99_RS17795	COG0673	inositol 2-dehydrogenase activity
MTO99_RS17800	COG1609	Transcriptional regulator
MTO99_RS17805	COG1653	transport
MTO99_RS17810	COG0395	ABC-type sugar transport system, permease component
MTO99_RS17815	COG1175	transmembrane transport
MTO99_RS17820	COG1609	Transcriptional regulator
MTO99_RS17825	COG1653	transport
MTO99_RS17830	COG1175	transmembrane transport
MTO99_RS17835	COG0395	ABC-type sugar transport system, permease component
MTO99_RS17845	COG1132	(ABC) transporter
MTO99_RS17850	COG0840	transmembrane signaling receptor activity
MTO99_RS17855	COG3264	Mechanosensitive ion channel
MTO99_RS17855	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MTO99_RS17870	COG0531	amino acid
MTO99_RS17900	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTO99_RS17915	COG1609	Transcriptional regulator
MTO99_RS17925	COG4213	ABC transporter substrate-binding protein
MTO99_RS17930	COG1129	ABC transporter
MTO99_RS17945	COG2160	L-arabinose isomerase activity
MTO99_RS17950	COG1609	Transcriptional regulator
MTO99_RS17955	COG3345	alpha-galactosidase
MTO99_RS17965	COG3507	Belongs to the glycosyl hydrolase 43 family
MTO99_RS17970	COG3507	Belongs to the glycosyl hydrolase 43 family
MTO99_RS17990	COG1609	Transcriptional regulator
MTO99_RS18025	COG4585	Histidine kinase
MTO99_RS18030	COG2197	response regulator
MTO99_RS18060	COG1780	Probably involved in ribonucleotide reductase function
MTO99_RS18065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTO99_RS18070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTO99_RS18105	COG2018	Roadblock/LC7 domain
MTO99_RS18120	COG2197	response regulator
MTO99_RS18125	COG4585	Histidine kinase
MTO99_RS18170	COG1609	Transcriptional regulator
MTO99_RS18185	COG1846	Transcriptional regulator
MTO99_RS18210	COG2197	response regulator
MTO99_RS18225	COG0477	Major facilitator Superfamily
MTO99_RS18240	COG1335	isochorismatase
MTO99_RS18275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTO99_RS18280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MTO99_RS18285	COG1116	anion transmembrane transporter activity
MTO99_RS18290	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS18295	COG0477	Major facilitator Superfamily
MTO99_RS18305	COG1414	Transcriptional regulator
MTO99_RS18320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MTO99_RS18325	COG1140	nitrate reductase beta subunit
MTO99_RS18360	COG2873	o-acetylhomoserine
MTO99_RS18405	COG1396	sequence-specific DNA binding
MTO99_RS18425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MTO99_RS18440	COG0596	Alpha beta hydrolase
MTO99_RS18460	COG1846	Transcriptional regulator
MTO99_RS18465	COG1595	DNA-templated transcription, initiation
MTO99_RS18475	COG1595	DNA-templated transcription, initiation
MTO99_RS18480	COG0596	Alpha beta hydrolase
MTO99_RS18490	COG0662	Cupin 2, conserved barrel domain protein
MTO99_RS18505	COG0657	acetylesterase activity
MTO99_RS18550	COG1063	alcohol dehydrogenase
MTO99_RS18565	COG1595	DNA-templated transcription, initiation
MTO99_RS18595	COG4585	Histidine kinase
MTO99_RS18600	COG2197	response regulator
MTO99_RS18670	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MTO99_RS18720	COG0542	response to heat
MTO99_RS18735	COG2197	response regulator
MTO99_RS18740	COG4585	Histidine kinase
MTO99_RS18775	COG1960	acyl-CoA dehydrogenase activity
MTO99_RS18780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTO99_RS18785	COG0596	Alpha beta hydrolase
MTO99_RS18820	COG1793	dna ligase
MTO99_RS18825	COG0490	domain, Protein
MTO99_RS18825	COG0471	metal ion transport
MTO99_RS18835	COG1609	Transcriptional regulator
MTO99_RS18845	COG0395	ABC-type sugar transport system, permease component
MTO99_RS18850	COG1653	transport
MTO99_RS18875	COG0406	alpha-ribazole phosphatase activity
MTO99_RS18905	COG1796	DNA polymerase
MTO99_RS18905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MTO99_RS18920	COG1846	Transcriptional regulator
MTO99_RS18950	COG4214	carbohydrate transport
MTO99_RS18960	COG4213	ABC transporter substrate-binding protein
MTO99_RS18965	COG4552	Acetyltransferase involved in intracellular survival and related
MTO99_RS18985	COG0673	inositol 2-dehydrogenase activity
MTO99_RS18990	COG1609	Transcriptional regulator
MTO99_RS19000	COG4948	Mandelate Racemase Muconate Lactonizing
MTO99_RS19005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTO99_RS19015	COG1609	Transcriptional regulator
MTO99_RS19020	COG1929	Belongs to the glycerate kinase type-1 family