locus-tag	class	description
ET445_RS00010	COG1929	Belongs to the glycerate kinase type-1 family
ET445_RS00020	COG4552	Acetyltransferase involved in intracellular survival and related
ET445_RS00035	COG4214	carbohydrate transport
ET445_RS00055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ET445_RS00120	COG2226	methyltransferase
ET445_RS00135	COG4702	Belongs to the UPF0303 family
ET445_RS00190	COG1247	-acetyltransferase
ET445_RS00205	COG1793	dna ligase
ET445_RS00225	COG0667	Aldo Keto reductase
ET445_RS00230	COG1309	transcriptional regulator
ET445_RS00235	COG0300	oxidoreductase activity
ET445_RS00245	COG4989	oxidoreductase activity
ET445_RS00270	COG1120	ATPase activity
ET445_RS00275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS00280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS00305	COG1132	(ABC) transporter
ET445_RS00345	COG2837	iron assimilation
ET445_RS00400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_RS00405	COG1175	transmembrane transport
ET445_RS00410	COG0395	ABC-type sugar transport system, permease component
ET445_RS00415	COG1653	transport
ET445_RS00430	COG3250	beta-galactosidase activity
ET445_RS00435	COG0542	response to heat
ET445_RS00540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ET445_RS00550	COG0596	Alpha beta hydrolase
ET445_RS00555	COG2197	response regulator
ET445_RS00565	COG0488	(ABC) transporter
ET445_RS00630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ET445_RS00640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_RS00645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_RS00655	COG0596	Alpha beta hydrolase
ET445_RS00675	COG0477	Major facilitator Superfamily
ET445_RS00680	COG2814	Major facilitator Superfamily
ET445_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS00710	COG0640	Transcriptional regulator
ET445_RS00715	COG1846	Transcriptional regulator
ET445_RS00720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ET445_RS00760	COG1053	succinate dehydrogenase
ET445_RS00765	COG0251	oxidation-reduction process
ET445_RS00780	COG1396	sequence-specific DNA binding
ET445_RS00805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET445_RS00815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET445_RS00820	COG1780	Probably involved in ribonucleotide reductase function
ET445_RS00845	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_RS00855	COG1609	Transcriptional regulator
ET445_RS00875	COG0531	amino acid
ET445_RS00900	COG0668	transmembrane transport
ET445_RS00905	COG0840	transmembrane signaling receptor activity
ET445_RS00910	COG1132	(ABC) transporter
ET445_RS00915	COG0395	ABC-type sugar transport system, permease component
ET445_RS00920	COG1175	transmembrane transport
ET445_RS00925	COG1653	transport
ET445_RS00930	COG1609	Transcriptional regulator
ET445_RS00935	COG2814	Major facilitator Superfamily
ET445_RS00940	COG1846	Transcriptional regulator
ET445_RS00950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ET445_RS00955	COG0477	Major facilitator Superfamily
ET445_RS00970	COG2205	protein histidine kinase activity
ET445_RS00975	COG0745	RESPONSE REGULATOR receiver
ET445_RS00985	COG1136	(ABC) transporter
ET445_RS01015	COG3321	synthase
ET445_RS01015	COG0604	alcohol dehydrogenase
ET445_RS01035	COG0631	protein serine/threonine phosphatase activity
ET445_RS01055	COG0714	Associated with various cellular activities
ET445_RS01125	COG1404	Belongs to the peptidase S8 family
ET445_RS01145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ET445_RS01170	COG1090	epimerase
ET445_RS01235	COG2211	Major facilitator Superfamily
ET445_RS01270	COG1126	abc transporter atp-binding protein
ET445_RS01275	COG0765	amino acid transport
ET445_RS01280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET445_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS01300	COG1254	Belongs to the acylphosphatase family
ET445_RS01305	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS01310	COG1309	transcriptional regulator
ET445_RS01330	COG1960	acyl-CoA dehydrogenase activity
ET445_RS01335	COG0081	regulation of translation
ET445_RS01340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ET445_RS01375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ET445_RS01390	COG0436	Aminotransferase
ET445_RS01395	COG0583	DNA-binding transcription factor activity
ET445_RS01405	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
ET445_RS01415	COG3795	YCII-related domain
ET445_RS01425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ET445_RS01440	COG3850	Histidine kinase
ET445_RS01445	COG2197	response regulator
ET445_RS01450	COG3397	chitin binding
ET445_RS01455	COG3397	chitin binding
ET445_RS01460	COG0531	amino acid
ET445_RS01465	COG2197	response regulator
ET445_RS01485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ET445_RS01490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ET445_RS01500	COG2030	dehydratase
ET445_RS01510	COG0438	transferase activity, transferring glycosyl groups
ET445_RS01515	COG0438	transferase activity, transferring glycosyl groups
ET445_RS01520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET445_RS01610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ET445_RS01620	COG0484	heat shock protein binding
ET445_RS01630	COG3285	dna ligase
ET445_RS01630	COG1793	dna ligase
ET445_RS01685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_RS01695	COG0395	ABC-type sugar transport system, permease component
ET445_RS01705	COG2182	Extracellular solute-binding protein
ET445_RS01730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ET445_RS01740	COG1349	DNA-binding transcription factor activity
ET445_RS01760	COG3833	ABC-type maltose transport systems, permease component
ET445_RS01765	COG1175	transmembrane transport
ET445_RS01770	COG2182	Extracellular solute-binding protein
ET445_RS01775	COG0366	Alpha amylase catalytic
ET445_RS01780	COG0739	heme binding
ET445_RS01790	COG2801	Transposase and inactivated derivatives
ET445_RS01790	COG3415	Transposase
ET445_RS01810	COG1609	Transcriptional regulator
ET445_RS01820	COG1666	GTP binding
ET445_RS01845	COG0142	geranyltranstransferase activity
ET445_RS01850	COG2226	methyltransferase
ET445_RS01865	COG2326	polyphosphate kinase activity
ET445_RS01870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ET445_RS01895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ET445_RS01910	COG1410	methionine synthase
ET445_RS01910	COG0646	methionine synthase
ET445_RS01915	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS01930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ET445_RS01940	COG0785	Cytochrome C biogenesis protein
ET445_RS01945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET445_RS01950	COG0406	alpha-ribazole phosphatase activity
ET445_RS01960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ET445_RS01985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ET445_RS01990	COG0569	domain protein
ET445_RS01995	COG1131	(ABC) transporter
ET445_RS02000	COG3559	Exporter of polyketide antibiotics
ET445_RS02020	COG0246	Mannitol dehydrogenase
ET445_RS02030	COG1609	Transcriptional regulator
ET445_RS02035	COG1904	glucuronate isomerase
ET445_RS02040	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS02085	COG0395	ABC-type sugar transport system, permease component
ET445_RS02090	COG3458	cephalosporin-C deacetylase activity
ET445_RS02095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ET445_RS02100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ET445_RS02115	COG0519	Catalyzes the synthesis of GMP from XMP
ET445_RS02115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ET445_RS02125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ET445_RS02135	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_RS02140	COG2197	response regulator
ET445_RS02195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_RS02200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_RS02205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET445_RS02220	COG0395	ABC-type sugar transport system, permease component
ET445_RS02225	COG4209	transmembrane transport
ET445_RS02235	COG0366	Alpha amylase catalytic
ET445_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS02285	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ET445_RS02310	COG2909	trisaccharide binding
ET445_RS02315	COG3119	arylsulfatase activity
ET445_RS02320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ET445_RS02325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ET445_RS02330	COG1414	Transcriptional regulator
ET445_RS02390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ET445_RS02390	COG3608	succinylglutamate desuccinylase aspartoacylase
ET445_RS02410	COG1316	TRANSCRIPTIONal
ET445_RS02420	COG1316	TRANSCRIPTIONal
ET445_RS02425	COG0561	phosphatase activity
ET445_RS02430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ET445_RS02435	COG1597	lipid kinase activity
ET445_RS02450	COG0077	Prephenate dehydratase
ET445_RS02455	COG2733	membrane
ET445_RS02475	COG1876	peptidase activity
ET445_RS02490	COG0395	ABC-type sugar transport system, permease component
ET445_RS02505	COG3550	peptidyl-serine autophosphorylation
ET445_RS02540	COG2188	Transcriptional regulator
ET445_RS02545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ET445_RS02555	COG0095	Lipoate-protein ligase
ET445_RS02565	COG0366	Alpha amylase catalytic
ET445_RS02570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET445_RS02585	COG1082	Xylose isomerase domain protein TIM barrel
ET445_RS02590	COG1063	alcohol dehydrogenase
ET445_RS02595	COG0395	ABC-type sugar transport system, permease component
ET445_RS02600	COG1175	transmembrane transport
ET445_RS02620	COG1305	Transglutaminase-like
ET445_RS02640	COG2814	Major facilitator Superfamily
ET445_RS02645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ET445_RS02655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ET445_RS02665	COG0693	protein deglycase activity
ET445_RS02680	COG2188	Transcriptional regulator
ET445_RS02705	COG1940	carbohydrate kinase activity
ET445_RS02715	COG2814	Major facilitator Superfamily
ET445_RS02720	COG3104	oligopeptide transport
ET445_RS02750	COG1725	Transcriptional regulator
ET445_RS02760	COG1725	Transcriptional regulator
ET445_RS02765	COG0189	ligase activity
ET445_RS02765	COG0569	domain protein
ET445_RS02770	COG4067	protein conserved in archaea
ET445_RS02770	COG0189	ligase activity
ET445_RS02775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS02840	COG1733	regulation of RNA biosynthetic process
ET445_RS02865	COG1309	transcriptional regulator
ET445_RS02895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ET445_RS02900	COG2079	MmgE PrpD family protein
ET445_RS02910	COG0822	iron-sulfur transferase activity
ET445_RS02915	COG1024	Enoyl-CoA hydratase
ET445_RS02920	COG1280	lysine exporter protein (LysE YggA)
ET445_RS02930	COG1054	Belongs to the UPF0176 family
ET445_RS02955	COG1131	(ABC) transporter
ET445_RS02985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ET445_RS02990	COG0113	porphobilinogen synthase activity
ET445_RS03005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ET445_RS03040	COG0644	oxidoreductase
ET445_RS03085	COG0423	glycine-tRNA ligase activity
ET445_RS03095	COG0477	Major facilitator Superfamily
ET445_RS03120	COG3590	peptidase
ET445_RS03125	COG3304	Inner membrane component domain
ET445_RS03135	COG0534	Mate efflux family protein
ET445_RS03150	COG0300	oxidoreductase activity
ET445_RS03155	COG0156	8-amino-7-oxononanoate synthase activity
ET445_RS03160	COG1063	alcohol dehydrogenase
ET445_RS03180	COG1309	transcriptional regulator
ET445_RS03200	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ET445_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS03210	COG0546	phosphoglycolate phosphatase activity
ET445_RS03235	COG0477	Major facilitator Superfamily
ET445_RS03250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ET445_RS03270	COG0386	Belongs to the glutathione peroxidase family
ET445_RS03275	COG2197	response regulator
ET445_RS03295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ET445_RS03315	COG2837	iron assimilation
ET445_RS03320	COG2822	iron ion transport
ET445_RS03365	COG1846	Transcriptional regulator
ET445_RS03375	COG3591	Belongs to the peptidase S1B family
ET445_RS03375	COG1864	DNA RNA non-specific endonuclease
ET445_RS03395	COG3458	cephalosporin-C deacetylase activity
ET445_RS03430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_RS03435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_RS03450	COG0640	Transcriptional regulator
ET445_RS03460	COG1053	succinate dehydrogenase
ET445_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS03470	COG0657	acetylesterase activity
ET445_RS03510	COG0492	ferredoxin-NADP+ reductase activity
ET445_RS03535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ET445_RS03550	COG0667	Aldo Keto reductase
ET445_RS03555	COG0657	acetylesterase activity
ET445_RS03560	COG1595	DNA-templated transcription, initiation
ET445_RS03565	COG1846	Transcriptional regulator
ET445_RS03570	COG0596	Alpha beta hydrolase
ET445_RS03575	COG1595	DNA-templated transcription, initiation
ET445_RS03610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET445_RS03615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET445_RS03625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_RS03665	COG0598	Magnesium transport protein CorA
ET445_RS03675	COG1309	transcriptional regulator
ET445_RS03700	COG3328	transposase activity
ET445_RS03740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_RS03750	COG3328	transposase activity
ET445_RS03785	COG1716	ATPase activity
ET445_RS03805	COG0515	serine threonine protein kinase
ET445_RS03810	COG0515	serine threonine protein kinase
ET445_RS03820	COG3764	Sortase (surface protein transpeptidase)
ET445_RS03830	COG0457	Tetratricopeptide repeat
ET445_RS03830	COG0705	Rhomboid family
ET445_RS03850	COG0494	nUDIX hydrolase
ET445_RS03855	COG0667	Aldo Keto reductase
ET445_RS03870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ET445_RS03895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ET445_RS03900	COG0187	DNA topoisomerase II activity
ET445_RS03905	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ET445_RS03910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ET445_RS03915	COG0592	DNA-directed DNA polymerase activity
ET445_RS03920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ET445_RS03925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ET445_RS03930	COG0594	ribonuclease P activity
ET445_RS03935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ET445_RS03940	COG0706	membrane insertase activity
ET445_RS03950	COG0357	Ribosomal RNA small subunit methyltransferase G
ET445_RS03955	COG1192	Involved in chromosome partitioning
ET445_RS03975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ET445_RS03980	COG3118	belongs to the thioredoxin family
ET445_RS03985	COG0492	ferredoxin-NADP+ reductase activity
ET445_RS04010	COG0617	tRNA 3'-terminal CCA addition
ET445_RS04015	COG0360	Binds together with S18 to 16S ribosomal RNA
ET445_RS04025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ET445_RS04030	COG0359	binds to the 23S rRNA
ET445_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS04115	COG0667	Aldo Keto reductase
ET445_RS04125	COG0534	Mate efflux family protein
ET445_RS04135	COG1132	(ABC) transporter
ET445_RS04140	COG1132	(ABC) transporter
ET445_RS04145	COG1725	Transcriptional regulator
ET445_RS04165	COG0601	transmembrane transport
ET445_RS04170	COG0747	negative chemotaxis
ET445_RS04205	COG1940	carbohydrate kinase activity
ET445_RS04215	COG1175	transmembrane transport
ET445_RS04220	COG0395	ABC-type sugar transport system, permease component
ET445_RS04265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ET445_RS04270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_RS04290	COG1950	PFAM Membrane protein of
ET445_RS04295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ET445_RS04315	COG2873	o-acetylhomoserine
ET445_RS04335	COG1121	(ABC) transporter
ET445_RS04340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ET445_RS04355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ET445_RS04360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ET445_RS04365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ET445_RS04370	COG0776	regulation of translation
ET445_RS04375	COG3336	cytochrome c oxidase
ET445_RS04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ET445_RS04390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ET445_RS04405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ET445_RS04430	COG0717	Belongs to the dCTP deaminase family
ET445_RS04480	COG4608	Belongs to the ABC transporter superfamily
ET445_RS04485	COG0601	transmembrane transport
ET445_RS04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET445_RS04495	COG0444	Belongs to the ABC transporter superfamily
ET445_RS04505	COG1648	precorrin-2 dehydrogenase activity
ET445_RS04505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ET445_RS04510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_RS04515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ET445_RS04535	COG0175	sulfate reduction
ET445_RS04540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ET445_RS04570	COG3655	Transcriptional regulator
ET445_RS04590	COG0701	Predicted permease
ET445_RS04595	COG0443	Heat shock 70 kDa protein
ET445_RS04600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ET445_RS04605	COG0484	heat shock protein binding
ET445_RS04610	COG0789	Transcriptional regulator
ET445_RS04625	COG2813	Specifically methylates the guanine in position
ET445_RS04630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ET445_RS04645	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ET445_RS04655	COG0628	permease
ET445_RS04680	COG3424	synthase
ET445_RS04685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ET445_RS04720	COG0542	response to heat
ET445_RS04730	COG2272	Belongs to the type-B carboxylesterase lipase family
ET445_RS04735	COG0477	Major facilitator Superfamily
ET445_RS04770	COG4152	abc transporter atp-binding protein
ET445_RS04780	COG0662	Cupin 2, conserved barrel domain protein
ET445_RS04785	COG2197	response regulator
ET445_RS04800	COG0659	secondary active sulfate transmembrane transporter activity
ET445_RS04850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET445_RS04855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_RS04865	COG1116	anion transmembrane transporter activity
ET445_RS04870	COG0300	oxidoreductase activity
ET445_RS04875	COG0346	lactoylglutathione lyase activity
ET445_RS04890	COG0778	Nitroreductase
ET445_RS04890	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ET445_RS04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS04900	COG1920	GTP binding
ET445_RS04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS04925	COG1120	ATPase activity
ET445_RS04930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS04955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ET445_RS04970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET445_RS04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_RS04985	COG1116	anion transmembrane transporter activity
ET445_RS04990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET445_RS04995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ET445_RS05000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ET445_RS05025	COG3340	Belongs to the peptidase S51 family
ET445_RS05030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ET445_RS05040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ET445_RS05055	COG0747	negative chemotaxis
ET445_RS05115	COG0492	ferredoxin-NADP+ reductase activity
ET445_RS05125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET445_RS05135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ET445_RS05135	COG2066	Belongs to the glutaminase family
ET445_RS05160	COG0598	Magnesium transport protein CorA
ET445_RS05180	COG0137	argininosuccinate synthase activity
ET445_RS05195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ET445_RS05210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ET445_RS05225	COG3275	phosphorelay sensor kinase activity
ET445_RS05235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ET445_RS05240	COG0477	Major facilitator Superfamily
ET445_RS05245	COG1335	isochorismatase
ET445_RS05265	COG0697	spore germination
ET445_RS05270	COG2188	Transcriptional regulator
ET445_RS05275	COG1131	(ABC) transporter
ET445_RS05285	COG1605	Chorismate mutase
ET445_RS05285	COG0287	Prephenate dehydrogenase
ET445_RS05330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET445_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS05345	COG1053	succinate dehydrogenase
ET445_RS05350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET445_RS05355	COG0166	Belongs to the GPI family
ET445_RS05370	COG0471	metal ion transport
ET445_RS05380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ET445_RS05390	COG3537	Alpha-1,2-mannosidase
ET445_RS05395	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ET445_RS05405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET445_RS05425	COG3483	tryptophan 2,3-dioxygenase activity
ET445_RS05435	COG2514	catechol 2,3-dioxygenase activity
ET445_RS05440	COG3548	integral membrane protein
ET445_RS05445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ET445_RS05450	COG4558	Periplasmic binding protein
ET445_RS05455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS05460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ET445_RS05490	COG0151	Belongs to the GarS family
ET445_RS05560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ET445_RS05585	COG1802	Transcriptional regulator
ET445_RS05620	COG0789	Transcriptional regulator
ET445_RS05645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ET445_RS05670	COG2217	Heavy metal translocating P-type atpase
ET445_RS05685	COG1228	amidohydrolase
ET445_RS05690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ET445_RS05695	COG0739	heme binding
ET445_RS05695	COG0741	lytic transglycosylase activity
ET445_RS05695	COG1196	nuclear chromosome segregation
ET445_RS05710	COG0586	Pfam SNARE associated Golgi protein
ET445_RS05720	COG0456	acetyltransferase
ET445_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS05760	COG0183	Belongs to the thiolase family
ET445_RS05765	COG1024	Enoyl-CoA hydratase
ET445_RS05770	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_RS05775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS05775	COG2030	dehydratase
ET445_RS05785	COG0514	ATP-dependent DNA helicase (RecQ)
ET445_RS05810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS05815	COG1309	transcriptional regulator
ET445_RS05825	COG2050	protein possibly involved in aromatic compounds catabolism
ET445_RS05830	COG3396	Phenylacetate-CoA oxygenase
ET445_RS05835	COG3460	Phenylacetate-CoA oxygenase
ET445_RS05840	COG2151	metal-sulfur cluster biosynthetic enzyme
ET445_RS05845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ET445_RS05855	COG1320	monovalent cation:proton antiporter activity
ET445_RS05860	COG2212	antiporter activity
ET445_RS05870	COG0651	ATP synthesis coupled electron transport
ET445_RS05875	COG1006	Multisubunit Na H antiporter MnhC subunit
ET445_RS05880	COG2111	Na H antiporter
ET445_RS05880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ET445_RS05890	COG0545	Peptidyl-prolyl cis-trans isomerase
ET445_RS05895	COG0530	calcium, potassium:sodium antiporter activity
ET445_RS05915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ET445_RS05920	COG1122	ATPase activity
ET445_RS05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS05955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS05985	COG2957	Belongs to the agmatine deiminase family
ET445_RS06010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ET445_RS06035	COG1024	Enoyl-CoA hydratase
ET445_RS06035	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_RS06045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ET445_RS06055	COG1119	ATPase activity
ET445_RS06065	COG4977	sequence-specific DNA binding
ET445_RS06080	COG0740	serine-type endopeptidase activity
ET445_RS06085	COG0740	serine-type endopeptidase activity
ET445_RS06110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ET445_RS06115	COG0351	phosphomethylpyrimidine kinase
ET445_RS06115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ET445_RS06115	COG0352	thiamine-phosphate diphosphorylase activity
ET445_RS06120	COG0352	thiamine-phosphate diphosphorylase activity
ET445_RS06125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ET445_RS06170	COG0494	nUDIX hydrolase
ET445_RS06225	COG4941	Belongs to the sigma-70 factor family
ET445_RS06255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_RS06270	COG2197	response regulator
ET445_RS06275	COG4585	Histidine kinase
ET445_RS06295	COG1620	l-lactate permease
ET445_RS06305	COG2197	response regulator
ET445_RS06320	COG1960	acyl-CoA dehydrogenase activity
ET445_RS06340	COG0395	ABC-type sugar transport system, permease component
ET445_RS06345	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_RS06350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ET445_RS06355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ET445_RS06360	COG1737	Transcriptional regulator
ET445_RS06370	COG0730	response to heat
ET445_RS06375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_RS06395	COG0656	L-ascorbic acid biosynthetic process
ET445_RS06400	COG2814	Major facilitator Superfamily
ET445_RS06405	COG1846	Transcriptional regulator
ET445_RS06415	COG0640	Transcriptional regulator
ET445_RS06435	COG0738	Major facilitator superfamily
ET445_RS06450	COG1309	transcriptional regulator
ET445_RS06460	COG0514	ATP-dependent DNA helicase (RecQ)
ET445_RS06485	COG0039	L-malate dehydrogenase activity
ET445_RS06505	COG0697	spore germination
ET445_RS06535	COG1278	Cold shock
ET445_RS06555	COG0277	FAD linked oxidase domain protein
ET445_RS06585	COG3619	membrane
ET445_RS06640	COG4974	Belongs to the 'phage' integrase family
ET445_RS06660	COG0739	heme binding
ET445_RS06660	COG0741	lytic transglycosylase activity
ET445_RS06660	COG1196	nuclear chromosome segregation
ET445_RS06665	COG3883	PFAM NLP P60 protein
ET445_RS06665	COG0791	NLP P60 protein
ET445_RS06670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ET445_RS06675	COG0037	tRNA processing
ET445_RS06680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ET445_RS06685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET445_RS06690	COG0302	gtp cyclohydrolase
ET445_RS06695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ET445_RS06700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ET445_RS06730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ET445_RS06735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ET445_RS06740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ET445_RS06755	COG3655	Transcriptional regulator
ET445_RS06775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ET445_RS06790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ET445_RS06805	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_RS06890	COG0513	Belongs to the DEAD box helicase family
ET445_RS06930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ET445_RS06955	COG0085	RNA polymerase activity
ET445_RS06960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ET445_RS06965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ET445_RS06975	COG1459	type II secretion system
ET445_RS07000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ET445_RS07115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ET445_RS07120	COG0049	tRNA binding
ET445_RS07125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ET445_RS07130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ET445_RS07140	COG0051	transcription antitermination factor activity, RNA binding
ET445_RS07145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ET445_RS07150	COG0088	Forms part of the polypeptide exit tunnel
ET445_RS07155	COG0089	rRNA binding
ET445_RS07160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET445_RS07165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ET445_RS07170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ET445_RS07175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ET445_RS07180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ET445_RS07185	COG0255	Belongs to the universal ribosomal protein uL29 family
ET445_RS07190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ET445_RS07195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ET445_RS07200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ET445_RS07205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET445_RS07210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ET445_RS07215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ET445_RS07220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ET445_RS07225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ET445_RS07230	COG1841	ribosomal large subunit assembly
ET445_RS07240	COG0200	Binds to the 23S rRNA
ET445_RS07250	COG0563	adenylate kinase activity
ET445_RS07255	COG0024	Methionine aminopeptidase
ET445_RS07260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ET445_RS07270	COG2213	PTS system mannitol-specific
ET445_RS07275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ET445_RS07290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ET445_RS07300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET445_RS07305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ET445_RS07310	COG0202	RNA polymerase activity
ET445_RS07315	COG0203	ribosomal protein L17
ET445_RS07325	COG0101	tRNA pseudouridine synthase activity
ET445_RS07330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ET445_RS07335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ET445_RS07340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_RS07345	COG1072	(Pantothenic acid kinase))
ET445_RS07350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET445_RS07355	COG0736	holo-[acyl-carrier-protein] synthase activity
ET445_RS07360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ET445_RS07365	COG0802	atpase or kinase
ET445_RS07380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ET445_RS07400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ET445_RS07450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ET445_RS07460	COG0516	GMP reductase activity
ET445_RS07480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ET445_RS07480	COG0519	Catalyzes the synthesis of GMP from XMP
ET445_RS07490	COG3795	YCII-related domain
ET445_RS07495	COG4941	Belongs to the sigma-70 factor family
ET445_RS07505	COG0584	glycerophosphoryl diester phosphodiesterase
ET445_RS07540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ET445_RS07545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ET445_RS07550	COG3639	organic phosphonate transmembrane transporter activity
ET445_RS07570	COG0045	succinate-CoA ligase (ADP-forming) activity
ET445_RS07620	COG0138	bifunctional purine biosynthesis protein purh
ET445_RS07625	COG1834	amidinotransferase
ET445_RS07630	COG1136	(ABC) transporter
ET445_RS07635	COG1136	(ABC) transporter
ET445_RS07635	COG0577	efflux transmembrane transporter activity
ET445_RS07655	COG1132	(ABC) transporter
ET445_RS07660	COG0019	diaminopimelate decarboxylase activity
ET445_RS07670	COG2197	response regulator
ET445_RS07675	COG4585	Histidine kinase
ET445_RS07690	COG0538	isocitrate dehydrogenase activity
ET445_RS07705	COG1175	transmembrane transport
ET445_RS07710	COG0395	ABC-type sugar transport system, permease component
ET445_RS07715	COG1472	Belongs to the glycosyl hydrolase 3 family
ET445_RS07720	COG1940	carbohydrate kinase activity
ET445_RS07765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ET445_RS07770	COG1349	DNA-binding transcription factor activity
ET445_RS07775	COG0191	fructose-bisphosphate aldolase activity
ET445_RS07790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET445_RS07805	COG0395	ABC-type sugar transport system, permease component
ET445_RS07820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ET445_RS07825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ET445_RS07845	COG1083	cytidylyl-transferase
ET445_RS07850	COG2089	acid synthase
ET445_RS07870	COG0442	prolyl-tRNA aminoacylation
ET445_RS07880	COG2017	converts alpha-aldose to the beta-anomer
ET445_RS07950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ET445_RS07970	COG0406	alpha-ribazole phosphatase activity
ET445_RS07970	COG0494	nUDIX hydrolase
ET445_RS07975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ET445_RS07980	COG0745	RESPONSE REGULATOR receiver
ET445_RS07990	COG3485	protocatechuate 3,4-dioxygenase
ET445_RS08005	COG0588	phosphoglycerate mutase activity
ET445_RS08020	COG0745	RESPONSE REGULATOR receiver
ET445_RS08035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ET445_RS08035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ET445_RS08040	COG0215	cysteine-tRNA ligase activity
ET445_RS08055	COG3842	ATPase activity
ET445_RS08080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ET445_RS08095	COG1278	Cold shock
ET445_RS08100	COG1470	cell adhesion involved in biofilm formation
ET445_RS08115	COG2205	protein histidine kinase activity
ET445_RS08120	COG0745	RESPONSE REGULATOR receiver
ET445_RS08130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ET445_RS08140	COG1061	Type III restriction enzyme res subunit
ET445_RS08155	COG1278	Cold shock
ET445_RS08170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ET445_RS08175	COG1321	iron dependent repressor
ET445_RS08180	COG0791	NLP P60 protein
ET445_RS08190	COG1388	LysM domain
ET445_RS08190	COG3942	CHAP domain
ET445_RS08215	COG3415	Transposase
ET445_RS08215	COG2801	Transposase and inactivated derivatives
ET445_RS08290	COG1793	dna ligase
ET445_RS08295	COG1522	sequence-specific DNA binding
ET445_RS08300	COG0686	Belongs to the AlaDH PNT family
ET445_RS08335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ET445_RS08365	COG2814	Major facilitator Superfamily
ET445_RS08370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS08390	COG0490	domain, Protein
ET445_RS08390	COG2985	domain, Protein
ET445_RS08410	COG0656	L-ascorbic acid biosynthetic process
ET445_RS08420	COG0640	Transcriptional regulator
ET445_RS08430	COG1643	Atp-dependent helicase
ET445_RS08455	COG1331	Highly conserved protein containing a thioredoxin domain
ET445_RS08475	COG0484	heat shock protein binding
ET445_RS08480	COG1362	aminopeptidase activity
ET445_RS08490	COG2897	thiosulfate sulfurtransferase activity
ET445_RS08515	COG1832	CoA-binding protein
ET445_RS08535	COG1335	isochorismatase
ET445_RS08575	COG2076	Multidrug Resistance protein
ET445_RS08585	COG1476	TRANSCRIPTIONal
ET445_RS08600	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
ET445_RS08620	COG0084	hydrolase, TatD family'
ET445_RS08625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ET445_RS08635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ET445_RS08640	COG0488	(ABC) transporter
ET445_RS08645	COG2813	Specifically methylates the guanine in position
ET445_RS08655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ET445_RS08660	COG2011	ABC-type metal ion transport system permease component
ET445_RS08670	COG1403	HNH endonuclease
ET445_RS08690	COG4221	oxidoreductase activity
ET445_RS08705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ET445_RS08715	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS08735	COG2149	membrane
ET445_RS08740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ET445_RS08760	COG0395	ABC-type sugar transport system, permease component
ET445_RS08765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ET445_RS08765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ET445_RS08775	COG1349	DNA-binding transcription factor activity
ET445_RS08780	COG0473	3-isopropylmalate dehydrogenase activity
ET445_RS08785	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS08840	COG0477	Major facilitator Superfamily
ET445_RS08900	COG0673	inositol 2-dehydrogenase activity
ET445_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS08915	COG3386	PFAM SMP-30 Gluconolaconase
ET445_RS08940	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS08950	COG1904	glucuronate isomerase
ET445_RS08955	COG1609	Transcriptional regulator
ET445_RS08965	COG0673	inositol 2-dehydrogenase activity
ET445_RS08975	COG0246	Mannitol dehydrogenase
ET445_RS08980	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS08985	COG3265	gluconokinase activity
ET445_RS08990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ET445_RS09015	COG0193	aminoacyl-tRNA hydrolase activity
ET445_RS09045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ET445_RS09060	COG0124	histidyl-tRNA synthetase
ET445_RS09075	COG0148	phosphopyruvate hydratase activity
ET445_RS09090	COG1404	Belongs to the peptidase S8 family
ET445_RS09105	COG2140	Oxalate decarboxylase
ET445_RS09110	COG0248	Ppx GppA phosphatase
ET445_RS09150	COG1704	LemA family
ET445_RS09160	COG3214	Protein conserved in bacteria
ET445_RS09170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ET445_RS09175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ET445_RS09195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET445_RS09205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ET445_RS09210	COG0114	fumarate hydratase activity
ET445_RS09225	COG1722	exodeoxyribonuclease VII activity
ET445_RS09230	COG1570	exodeoxyribonuclease VII activity
ET445_RS09235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ET445_RS09260	COG0191	fructose-bisphosphate aldolase activity
ET445_RS09265	COG1494	fructose-1,6-bisphosphatase
ET445_RS09280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS09285	COG4166	transmembrane transport
ET445_RS09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET445_RS09310	COG1619	proteins homologs of microcin C7 resistance protein MccF
ET445_RS09315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS09330	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS09335	COG1322	Protein conserved in bacteria
ET445_RS09340	COG2176	DNA-directed DNA polymerase activity
ET445_RS09360	COG0012	GTP binding
ET445_RS09370	COG2824	Alkylphosphonate utilization operon protein PhnA
ET445_RS09415	COG0488	(ABC) transporter
ET445_RS09465	COG1846	Transcriptional regulator
ET445_RS09470	COG0697	spore germination
ET445_RS09475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_RS09535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_RS09540	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_RS09560	COG2814	Major facilitator Superfamily
ET445_RS09565	COG1104	cysteine desulfurase activity
ET445_RS09575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ET445_RS09580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ET445_RS09605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ET445_RS09610	COG0509	glycine decarboxylation via glycine cleavage system
ET445_RS09615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ET445_RS09615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ET445_RS09635	COG4166	transmembrane transport
ET445_RS09640	COG0601	transmembrane transport
ET445_RS09655	COG1217	gtp-binding protein TYPA
ET445_RS09660	COG0741	lytic transglycosylase activity
ET445_RS09660	COG1196	nuclear chromosome segregation
ET445_RS09660	COG0739	heme binding
ET445_RS09700	COG2171	N-acyltransferase activity
ET445_RS09705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS09725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_RS09760	COG2239	Acts as a magnesium transporter
ET445_RS09770	COG0006	proline dipeptidase activity
ET445_RS09780	COG0613	PHP domain protein
ET445_RS09785	COG0513	Belongs to the DEAD box helicase family
ET445_RS09810	COG0210	DNA helicase
ET445_RS09835	COG3480	Lon protease (S16) C-terminal proteolytic domain
ET445_RS09840	COG1615	UPF0182 protein
ET445_RS09900	COG0488	(ABC) transporter
ET445_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS09915	COG0596	Alpha beta hydrolase
ET445_RS09925	COG0028	Belongs to the TPP enzyme family
ET445_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS09955	COG0598	Magnesium transport protein CorA
ET445_RS09960	COG0588	phosphoglycerate mutase activity
ET445_RS09965	COG0596	Alpha beta hydrolase
ET445_RS09970	COG3973	AAA domain
ET445_RS09980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ET445_RS09990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET445_RS10015	COG2337	Toxic component of a toxin-antitoxin (TA) module
ET445_RS10030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ET445_RS10115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ET445_RS10120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ET445_RS10125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ET445_RS10135	COG0586	Pfam SNARE associated Golgi protein
ET445_RS10150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ET445_RS10165	COG0490	domain, Protein
ET445_RS10165	COG0471	metal ion transport
ET445_RS10225	COG1733	regulation of RNA biosynthetic process
ET445_RS10235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ET445_RS10240	COG2884	Cell division ATP-binding protein ftsE
ET445_RS10250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ET445_RS10270	COG2271	Major facilitator Superfamily
ET445_RS10290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS10295	COG1120	ATPase activity
ET445_RS10300	COG0025	NhaP-type Na H and K H
ET445_RS10305	COG0483	inositol monophosphate 1-phosphatase activity
ET445_RS10340	COG2197	response regulator
ET445_RS10350	COG3634	alkyl hydroperoxide reductase activity
ET445_RS10360	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ET445_RS10365	COG1122	ATPase activity
ET445_RS10370	COG1268	BioY protein
ET445_RS10390	COG2409	Drug exporters of the RND superfamily
ET445_RS10395	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ET445_RS10400	COG0129	dihydroxy-acid dehydratase activity
ET445_RS10405	COG0028	Belongs to the TPP enzyme family
ET445_RS10410	COG0440	acetolactate synthase activity
ET445_RS10415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ET445_RS10420	COG0737	Belongs to the 5'-nucleotidase family
ET445_RS10420	COG4085	toxin activity
ET445_RS10420	COG1525	nuclease
ET445_RS10430	COG3629	intracellular signal transduction
ET445_RS10435	COG3142	Participates in the control of copper homeostasis
ET445_RS10465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ET445_RS10470	COG0456	acetyltransferase
ET445_RS10475	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET445_RS10485	COG3844	kynureninase activity
ET445_RS10490	COG0583	DNA-binding transcription factor activity
ET445_RS10495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ET445_RS10520	COG3550	peptidyl-serine autophosphorylation
ET445_RS10545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ET445_RS10545	COG1199	ATP-dependent helicase activity
ET445_RS10555	COG2801	Transposase and inactivated derivatives
ET445_RS10555	COG3415	Transposase
ET445_RS10585	COG0745	RESPONSE REGULATOR receiver
ET445_RS10590	COG2205	protein histidine kinase activity
ET445_RS10600	COG0596	Alpha beta hydrolase
ET445_RS10635	COG2188	Transcriptional regulator
ET445_RS10650	COG1129	ABC transporter
ET445_RS10655	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_RS10660	COG1070	Carbohydrate kinase
ET445_RS10665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ET445_RS10670	COG0800	Aldolase
ET445_RS10680	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ET445_RS10715	COG0492	ferredoxin-NADP+ reductase activity
ET445_RS10745	COG2910	NAD(P)H-binding
ET445_RS10760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET445_RS10790	COG0631	protein serine/threonine phosphatase activity
ET445_RS10820	COG0714	Associated with various cellular activities
ET445_RS10840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ET445_RS10845	COG0066	3-isopropylmalate dehydratase activity
ET445_RS10850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ET445_RS10855	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS10855	COG0204	Acyl-transferase
ET445_RS10860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ET445_RS10865	COG1181	Belongs to the D-alanine--D-alanine ligase family
ET445_RS10880	COG0742	ribosomal rna small subunit methyltransferase
ET445_RS10890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ET445_RS10895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ET445_RS10900	COG0714	Associated with various cellular activities
ET445_RS10920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ET445_RS10925	COG0571	ribonuclease III activity
ET445_RS10930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_RS10940	COG1196	nuclear chromosome segregation
ET445_RS10955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ET445_RS10980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ET445_RS10985	COG0228	four-way junction DNA binding
ET445_RS10990	COG1837	Belongs to the UPF0109 family
ET445_RS10995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ET445_RS11000	COG0336	Belongs to the RNA methyltransferase TrmD family
ET445_RS11020	COG0335	large ribosomal subunit rRNA binding
ET445_RS11025	COG0681	Belongs to the peptidase S26 family
ET445_RS11030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ET445_RS11040	COG0792	nuclease activity
ET445_RS11060	COG4974	Belongs to the 'phage' integrase family
ET445_RS11070	COG0052	Belongs to the universal ribosomal protein uS2 family
ET445_RS11075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ET445_RS11085	COG0233	cytoplasmic translational termination
ET445_RS11130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ET445_RS11135	COG0366	Alpha amylase catalytic
ET445_RS11140	COG0058	SHG alpha-glucan phosphorylase activity
ET445_RS11150	COG1523	belongs to the glycosyl hydrolase 13 family
ET445_RS11160	COG0482	sulfurtransferase activity
ET445_RS11165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ET445_RS11175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET445_RS11180	COG0154	amidase activity
ET445_RS11185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ET445_RS11195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ET445_RS11205	COG4721	ABC-type cobalt transport system, permease component
ET445_RS11220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ET445_RS11245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ET445_RS11255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ET445_RS11270	COG0667	Aldo Keto reductase
ET445_RS11275	COG0629	single-stranded DNA binding
ET445_RS11305	COG1946	Acyl-CoA thioesterase
ET445_RS11325	COG0668	transmembrane transport
ET445_RS11335	COG2197	response regulator
ET445_RS11360	COG3177	Filamentation induced by cAMP protein fic
ET445_RS11385	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ET445_RS11395	COG2197	response regulator
ET445_RS11400	COG0783	Belongs to the Dps family
ET445_RS11405	COG2197	response regulator
ET445_RS11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ET445_RS11425	COG2376	Dihydroxyacetone kinase
ET445_RS11445	COG0544	peptidyl-prolyl cis-trans isomerase activity
ET445_RS11455	COG0740	serine-type endopeptidase activity
ET445_RS11460	COG0740	serine-type endopeptidase activity
ET445_RS11465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ET445_RS11495	COG0756	dUTP diphosphatase activity
ET445_RS11515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ET445_RS11530	COG1250	3-hydroxyacyl-CoA dehydrogenase
ET445_RS11530	COG1024	Enoyl-CoA hydratase
ET445_RS11535	COG0183	Belongs to the thiolase family
ET445_RS11540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ET445_RS11580	COG0569	domain protein
ET445_RS11580	COG2985	domain, Protein
ET445_RS11605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ET445_RS11625	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ET445_RS11630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ET445_RS11645	COG0217	transcriptional regulatory protein
ET445_RS11650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ET445_RS11655	COG0632	four-way junction helicase activity
ET445_RS11660	COG2255	four-way junction helicase activity
ET445_RS11670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET445_RS11675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ET445_RS11680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ET445_RS11715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ET445_RS11720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ET445_RS11730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ET445_RS11735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ET445_RS11745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ET445_RS11750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ET445_RS11755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ET445_RS11760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ET445_RS11775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ET445_RS11780	COG0540	Belongs to the ATCase OTCase family
ET445_RS11785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET445_RS11795	COG0505	Belongs to the CarA family
ET445_RS11805	COG0284	orotidine-5'-phosphate decarboxylase activity
ET445_RS11810	COG0194	GDP metabolic process
ET445_RS11815	COG1758	RNA polymerase activity
ET445_RS11825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ET445_RS11835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ET445_RS11845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ET445_RS11850	COG0140	phosphoribosyl-ATP diphosphatase activity
ET445_RS11855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ET445_RS11860	COG0107	imidazoleglycerol-phosphate synthase activity
ET445_RS11865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ET445_RS11880	COG0134	indole-3-glycerol-phosphate synthase activity
ET445_RS11885	COG0133	tryptophan synthase activity
ET445_RS11890	COG0159	tryptophan synthase activity
ET445_RS11895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ET445_RS11900	COG0067	glutamate synthase
ET445_RS11900	COG0070	glutamate synthase
ET445_RS11900	COG0069	glutamate synthase activity
ET445_RS11935	COG0539	negative regulation of cytoplasmic translation
ET445_RS11945	COG0237	dephospho-CoA kinase activity
ET445_RS11950	COG0556	nucleotide-excision repair
ET445_RS11960	COG0322	excinuclease ABC activity
ET445_RS11965	COG1660	Displays ATPase and GTPase activities
ET445_RS11970	COG1481	regulation of sporulation
ET445_RS11985	COG0126	phosphoglycerate kinase activity
ET445_RS11990	COG0149	triose-phosphate isomerase activity
ET445_RS11995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ET445_RS12005	COG0363	glucosamine-6-phosphate deaminase activity
ET445_RS12020	COG0166	Belongs to the GPI family
ET445_RS12025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ET445_RS12035	COG0109	protoheme IX farnesyltransferase activity
ET445_RS12050	COG0719	Fe-S assembly protein
ET445_RS12060	COG0396	ATPase activity
ET445_RS12065	COG2151	metal-sulfur cluster biosynthetic enzyme
ET445_RS12085	COG0525	valine-tRNA ligase activity
ET445_RS12095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET445_RS12105	COG0747	negative chemotaxis
ET445_RS12125	COG0285	dihydrofolate synthase activity
ET445_RS12145	COG1530	ribonuclease E activity
ET445_RS12155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ET445_RS12160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ET445_RS12165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET445_RS12170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ET445_RS12175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ET445_RS12185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ET445_RS12190	COG0799	negative regulation of ribosome biogenesis
ET445_RS12200	COG3415	Transposase
ET445_RS12200	COG2801	Transposase and inactivated derivatives
ET445_RS12225	COG0022	dehydrogenase e1 component
ET445_RS12275	COG0488	(ABC) transporter
ET445_RS12300	COG0589	response to stress
ET445_RS12305	COG0560	Phosphoserine phosphatase
ET445_RS12305	COG3830	Belongs to the UPF0237 family
ET445_RS12315	COG0297	glycogen (starch) synthase activity
ET445_RS12320	COG1119	ATPase activity
ET445_RS12325	COG0254	rRNA binding
ET445_RS12335	COG2267	carboxylic ester hydrolase activity
ET445_RS12345	COG0406	alpha-ribazole phosphatase activity
ET445_RS12400	COG0531	amino acid
ET445_RS12425	COG0596	Alpha beta hydrolase
ET445_RS12430	COG0587	DNA-directed DNA polymerase activity
ET445_RS12450	COG0463	Glycosyl transferase, family 2
ET445_RS12465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS12470	COG1968	undecaprenyl-diphosphatase activity
ET445_RS12505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ET445_RS12510	COG0805	protein transport
ET445_RS12530	COG0584	glycerophosphoryl diester phosphodiesterase
ET445_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS12575	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ET445_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS12645	COG1461	Dihydroxyacetone kinase
ET445_RS12650	COG2376	Dihydroxyacetone kinase
ET445_RS12655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET445_RS12660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ET445_RS12665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ET445_RS12670	COG1845	cytochrome c oxidase, subunit III
ET445_RS12675	COG2010	Cytochrome c
ET445_RS12680	COG0723	plastoquinol--plastocyanin reductase activity
ET445_RS12685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ET445_RS12690	COG2226	methyltransferase
ET445_RS12700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ET445_RS12705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ET445_RS12715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET445_RS12735	COG0187	DNA topoisomerase II activity
ET445_RS12755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ET445_RS12765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ET445_RS12770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_RS12775	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_RS12785	COG0321	lipoyl(octanoyl) transferase activity
ET445_RS12790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ET445_RS12805	COG0174	glutamine synthetase
ET445_RS12810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ET445_RS12820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ET445_RS12845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ET445_RS12885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ET445_RS12900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ET445_RS12905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ET445_RS12910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ET445_RS12950	COG3639	organic phosphonate transmembrane transporter activity
ET445_RS12980	COG0242	peptide deformylase activity
ET445_RS12995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ET445_RS13025	COG0601	transmembrane transport
ET445_RS13035	COG0358	DNA primase activity
ET445_RS13040	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ET445_RS13055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ET445_RS13065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ET445_RS13075	COG2860	membrane
ET445_RS13090	COG1879	ABC-type sugar transport system periplasmic component
ET445_RS13095	COG1129	ABC transporter
ET445_RS13100	COG1172	Belongs to the binding-protein-dependent transport system permease family
ET445_RS13110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ET445_RS13115	COG0577	efflux transmembrane transporter activity
ET445_RS13120	COG1136	(ABC) transporter
ET445_RS13125	COG2197	response regulator
ET445_RS13130	COG4585	Histidine kinase
ET445_RS13135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ET445_RS13145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ET445_RS13155	COG0537	adenosine 5'-monophosphoramidase activity
ET445_RS13165	COG0484	heat shock protein binding
ET445_RS13170	COG1420	regulation of RNA biosynthetic process
ET445_RS13210	COG4762	Protein conserved in bacteria
ET445_RS13225	COG0268	Binds directly to 16S ribosomal RNA
ET445_RS13255	COG0495	leucyl-tRNA aminoacylation
ET445_RS13260	COG0512	Glutamine amidotransferase of anthranilate synthase
ET445_RS13260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ET445_RS13265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ET445_RS13275	COG1294	oxidase, subunit
ET445_RS13280	COG1271	oxidase subunit
ET445_RS13295	COG0586	Pfam SNARE associated Golgi protein
ET445_RS13300	COG1732	Glycine betaine
ET445_RS13305	COG1174	glycine betaine transport
ET445_RS13310	COG1174	glycine betaine transport
ET445_RS13330	COG0167	dihydroorotate dehydrogenase activity
ET445_RS13335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ET445_RS13340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ET445_RS13345	COG0587	DNA-directed DNA polymerase activity
ET445_RS13370	COG1799	cell septum assembly
ET445_RS13380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ET445_RS13395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ET445_RS13405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ET445_RS13410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ET445_RS13420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ET445_RS13425	COG0768	penicillin binding
ET445_RS13435	COG0275	rRNA processing
ET445_RS13460	COG1388	LysM domain
ET445_RS13460	COG3942	CHAP domain
ET445_RS13470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ET445_RS13480	COG1940	carbohydrate kinase activity
ET445_RS13520	COG1716	ATPase activity
ET445_RS13550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ET445_RS13560	COG3012	SEC-C Motif Domain Protein
ET445_RS13655	COG2909	trisaccharide binding
ET445_RS13685	COG1063	alcohol dehydrogenase
ET445_RS13695	COG0438	transferase activity, transferring glycosyl groups
ET445_RS13705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ET445_RS13705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ET445_RS13725	COG2226	methyltransferase
ET445_RS13785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ET445_RS13835	COG0300	oxidoreductase activity
ET445_RS13850	COG1309	transcriptional regulator
ET445_RS13960	COG1872	DUF167
ET445_RS13965	COG0477	Major facilitator Superfamily
ET445_RS13970	COG1160	GTP binding
ET445_RS13975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ET445_RS13990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ET445_RS14010	COG0494	nUDIX hydrolase
ET445_RS14015	COG0504	CTP synthase activity
ET445_RS14020	COG0497	DNA recombination
ET445_RS14025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ET445_RS14040	COG0647	UMP catabolic process
ET445_RS14060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ET445_RS14065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ET445_RS14080	COG2094	Belongs to the DNA glycosylase MPG family
ET445_RS14085	COG0165	Argininosuccinate lyase
ET445_RS14090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ET445_RS14105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ET445_RS14110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ET445_RS14120	COG0072	phenylalanine-tRNA ligase activity
ET445_RS14120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ET445_RS14125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ET445_RS14130	COG0765	amino acid transport
ET445_RS14135	COG0765	amino acid transport
ET445_RS14145	COG1126	abc transporter atp-binding protein
ET445_RS14150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ET445_RS14155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ET445_RS14160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ET445_RS14165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ET445_RS14175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ET445_RS14195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ET445_RS14200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ET445_RS14205	COG0131	Imidazoleglycerol-phosphate dehydratase
ET445_RS14220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ET445_RS14225	COG2267	carboxylic ester hydrolase activity
ET445_RS14230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ET445_RS14240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ET445_RS14245	COG2813	Specifically methylates the guanine in position
ET445_RS14250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ET445_RS14255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ET445_RS14260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ET445_RS14270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ET445_RS14285	COG1546	Belongs to the CinA family
ET445_RS14285	COG1058	Belongs to the CinA family
ET445_RS14295	COG1674	ftsk spoiiie
ET445_RS14300	COG0456	acetyltransferase
ET445_RS14305	COG0577	efflux transmembrane transporter activity
ET445_RS14310	COG1136	(ABC) transporter
ET445_RS14310	COG0577	efflux transmembrane transporter activity
ET445_RS14325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ET445_RS14330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ET445_RS14345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ET445_RS14365	COG1090	epimerase
ET445_RS14375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ET445_RS14390	COG0612	Peptidase, M16
ET445_RS14395	COG0667	Aldo Keto reductase
ET445_RS14410	COG1960	acyl-CoA dehydrogenase activity
ET445_RS14420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET445_RS14425	COG1309	transcriptional regulator
ET445_RS14435	COG1309	transcriptional regulator
ET445_RS14440	COG2154	pterin-4-alpha-carbinolamine dehydratase
ET445_RS14445	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_RS14450	COG0022	dehydrogenase e1 component
ET445_RS14465	COG0300	oxidoreductase activity
ET445_RS14470	COG2755	lipolytic protein G-D-S-L family
ET445_RS14475	COG1185	polyribonucleotide nucleotidyltransferase activity
ET445_RS14500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS14525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET445_RS14545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ET445_RS14555	COG2072	flavoprotein involved in K transport
ET445_RS14570	COG3189	MarR family transcriptional regulator
ET445_RS14575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ET445_RS14600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ET445_RS14615	COG0545	Peptidyl-prolyl cis-trans isomerase
ET445_RS14625	COG0277	FAD linked oxidase domain protein
ET445_RS14635	COG2186	Transcriptional regulator
ET445_RS14670	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS14675	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET445_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS14700	COG2233	PERMEase
ET445_RS14705	COG2252	PERMEase
ET445_RS14730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ET445_RS14755	COG1937	Protein conserved in bacteria
ET445_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS14775	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS14780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ET445_RS14785	COG2390	Transcriptional regulator
ET445_RS14800	COG2807	transmembrane transport
ET445_RS14805	COG0196	riboflavin kinase activity
ET445_RS14820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ET445_RS14825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ET445_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS14860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ET445_RS14865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ET445_RS14875	COG0195	Participates in both transcription termination and antitermination
ET445_RS14880	COG1611	Belongs to the LOG family
ET445_RS14885	COG0442	prolyl-tRNA aminoacylation
ET445_RS14900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ET445_RS14905	COG2267	carboxylic ester hydrolase activity
ET445_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
ET445_RS14930	COG1309	transcriptional regulator
ET445_RS14935	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS14960	COG0183	Belongs to the thiolase family
ET445_RS14975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ET445_RS14975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ET445_RS14995	COG1253	flavin adenine dinucleotide binding
ET445_RS15000	COG2197	response regulator
ET445_RS15005	COG4585	Histidine kinase
ET445_RS15010	COG0750	zinc metalloprotease
ET445_RS15015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ET445_RS15050	COG1177	transmembrane transport
ET445_RS15055	COG1176	ABC-type spermidine putrescine transport system, permease component I
ET445_RS15060	COG3842	ATPase activity
ET445_RS15105	COG0631	protein serine/threonine phosphatase activity
ET445_RS15120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ET445_RS15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ET445_RS15135	COG0667	Aldo Keto reductase
ET445_RS15140	COG2818	Glycosylase
ET445_RS15155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ET445_RS15160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ET445_RS15165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ET445_RS15170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ET445_RS15175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ET445_RS15180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ET445_RS15185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ET445_RS15190	COG0356	it plays a direct role in the translocation of protons across the membrane
ET445_RS15200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ET445_RS15230	COG2890	protein-(glutamine-N5) methyltransferase activity
ET445_RS15240	COG1045	serine acetyltransferase
ET445_RS15250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ET445_RS15260	COG0083	homoserine kinase activity
ET445_RS15265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ET445_RS15270	COG0460	homoserine dehydrogenase
ET445_RS15275	COG0019	diaminopimelate decarboxylase activity
ET445_RS15290	COG1940	carbohydrate kinase activity
ET445_RS15305	COG1595	DNA-templated transcription, initiation
ET445_RS15320	COG1842	Phage shock protein A
ET445_RS15325	COG0010	Belongs to the arginase family
ET445_RS15330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ET445_RS15355	COG1120	ATPase activity
ET445_RS15360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS15365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ET445_RS15375	COG0154	amidase activity
ET445_RS15385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ET445_RS15395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ET445_RS15415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ET445_RS15465	COG0765	amino acid transport
ET445_RS15470	COG1126	abc transporter atp-binding protein
ET445_RS15480	COG1011	Hydrolase
ET445_RS15485	COG1902	pentaerythritol trinitrate reductase activity
ET445_RS15515	COG1136	(ABC) transporter
ET445_RS15525	COG0567	Dehydrogenase, E1 component
ET445_RS15525	COG0508	dehydrogenase complex catalyzes the overall conversion of
ET445_RS15535	COG1595	DNA-templated transcription, initiation
ET445_RS15540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ET445_RS15545	COG1162	GTPase activity
ET445_RS15595	COG0653	protein targeting
ET445_RS15600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ET445_RS15605	COG1040	competence protein
ET445_RS15610	COG5401	PFAM Sporulation and spore germination
ET445_RS15615	COG5002	protein histidine kinase activity
ET445_RS15640	COG0714	Associated with various cellular activities
ET445_RS15650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET445_RS15665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ET445_RS15680	COG1063	alcohol dehydrogenase
ET445_RS15685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_RS15715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ET445_RS15720	COG4977	sequence-specific DNA binding
ET445_RS15725	COG1482	cell wall glycoprotein biosynthetic process
ET445_RS15730	COG1960	acyl-CoA dehydrogenase activity
ET445_RS15755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ET445_RS15765	COG0673	inositol 2-dehydrogenase activity
ET445_RS15770	COG1216	Glycosyl transferase, family 2
ET445_RS15780	COG1215	transferase activity, transferring glycosyl groups
ET445_RS15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_RS15855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ET445_RS15865	COG1216	Glycosyl transferase, family 2
ET445_RS15865	COG0438	transferase activity, transferring glycosyl groups
ET445_RS15885	COG1088	dTDP-glucose 4,6-dehydratase activity
ET445_RS15900	COG1316	TRANSCRIPTIONal
ET445_RS15940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET445_RS15965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ET445_RS15970	COG0424	maF-like protein
ET445_RS15975	COG4770	biotin carboxylase activity
ET445_RS15995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ET445_RS16000	COG0531	amino acid
ET445_RS16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ET445_RS16030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ET445_RS16045	COG1079	Belongs to the binding-protein-dependent transport system permease family
ET445_RS16050	COG4603	Belongs to the binding-protein-dependent transport system permease family
ET445_RS16055	COG3845	ABC transporter
ET445_RS16060	COG1744	ABC transporter substrate-binding protein PnrA-like
ET445_RS16065	COG1744	ABC transporter substrate-binding protein PnrA-like
ET445_RS16075	COG2009	succinate dehydrogenase
ET445_RS16090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET445_RS16110	COG0708	Exodeoxyribonuclease III
ET445_RS16115	COG0180	Tryptophanyl-tRNA synthetase
ET445_RS16120	COG1011	Hydrolase
ET445_RS16130	COG2390	Transcriptional regulator
ET445_RS16135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ET445_RS16140	COG1695	Transcriptional regulator
ET445_RS16155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET445_RS16155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ET445_RS16160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ET445_RS16170	COG0477	Major facilitator Superfamily
ET445_RS16195	COG1132	(ABC) transporter
ET445_RS16215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ET445_RS16240	COG0183	Belongs to the thiolase family
ET445_RS16265	COG3971	2-oxopent-4-enoate hydratase activity
ET445_RS16275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ET445_RS16285	COG1012	belongs to the aldehyde dehydrogenase family
ET445_RS16305	COG1335	isochorismatase
ET445_RS16365	COG1754	DNA topoisomerase type I activity
ET445_RS16365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ET445_RS16410	COG0110	maltose O-acetyltransferase activity
ET445_RS16415	COG0438	transferase activity, transferring glycosyl groups
ET445_RS16430	COG2244	polysaccharide biosynthetic process
ET445_RS16460	COG1215	transferase activity, transferring glycosyl groups
ET445_RS16465	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS16470	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
ET445_RS16485	COG2091	lysine biosynthetic process via aminoadipic acid
ET445_RS16500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET445_RS16505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ET445_RS16525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET445_RS16540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ET445_RS16630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET445_RS16635	COG0489	protein tyrosine kinase activity
ET445_RS16670	COG0488	(ABC) transporter
ET445_RS16675	COG0579	oxidoreductase
ET445_RS16685	COG1486	melibiose metabolic process
ET445_RS16690	COG1940	carbohydrate kinase activity
ET445_RS16690	COG1846	Transcriptional regulator
ET445_RS16695	COG4608	Belongs to the ABC transporter superfamily
ET445_RS16700	COG0444	Belongs to the ABC transporter superfamily
ET445_RS16710	COG0601	transmembrane transport
ET445_RS16725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ET445_RS16730	COG1414	Transcriptional regulator
ET445_RS16765	COG5002	protein histidine kinase activity
ET445_RS16790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ET445_RS16815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ET445_RS16830	COG0385	Bile acid
ET445_RS16850	COG3415	Transposase
ET445_RS16850	COG2801	Transposase and inactivated derivatives
ET445_RS16865	COG0456	acetyltransferase
ET445_RS16870	COG0433	COG0433 Predicted ATPase
ET445_RS16905	COG0315	cyclic pyranopterin monophosphate synthase activity
ET445_RS16915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ET445_RS16920	COG0314	molybdopterin synthase activity
ET445_RS16925	COG0521	Mo-molybdopterin cofactor biosynthetic process
ET445_RS16925	COG0315	cyclic pyranopterin monophosphate synthase activity
ET445_RS16940	COG4948	Mandelate Racemase Muconate Lactonizing
ET445_RS16960	COG0277	FAD linked oxidase domain protein
ET445_RS16970	COG2814	Major facilitator Superfamily
ET445_RS16985	COG1175	transmembrane transport
ET445_RS16990	COG0395	ABC-type sugar transport system, permease component
ET445_RS17005	COG2115	Belongs to the xylose isomerase family
ET445_RS17010	COG1070	Carbohydrate kinase
ET445_RS17015	COG3693	PFAM glycoside hydrolase, family 10