locus-tag	class	description
FHG54_RS00015	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS00020	COG1957	nucleoside hydrolase
FHG54_RS00045	COG1070	Carbohydrate kinase
FHG54_RS00050	COG2115	Belongs to the xylose isomerase family
FHG54_RS00065	COG1309	transcriptional regulator
FHG54_RS00080	COG2186	Transcriptional regulator
FHG54_RS00085	COG0477	Major facilitator Superfamily
FHG54_RS00105	COG1733	regulation of RNA biosynthetic process
FHG54_RS00135	COG0366	Alpha amylase catalytic
FHG54_RS00140	COG3833	ABC-type maltose transport systems, permease component
FHG54_RS00145	COG1175	transmembrane transport
FHG54_RS00150	COG2182	Extracellular solute-binding protein
FHG54_RS00155	COG0366	Alpha amylase catalytic
FHG54_RS00165	COG0739	heme binding
FHG54_RS00190	COG1609	Transcriptional regulator
FHG54_RS00195	COG1666	GTP binding
FHG54_RS00220	COG0142	geranyltranstransferase activity
FHG54_RS00225	COG2226	methyltransferase
FHG54_RS00230	COG1169	isochorismate synthase
FHG54_RS00235	COG2326	polyphosphate kinase activity
FHG54_RS00240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FHG54_RS00280	COG4948	Mandelate Racemase Muconate Lactonizing
FHG54_RS00305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FHG54_RS00315	COG0785	Cytochrome C biogenesis protein
FHG54_RS00325	COG0406	alpha-ribazole phosphatase activity
FHG54_RS00330	COG0017	Asparaginyl-tRNA synthetase
FHG54_RS00335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FHG54_RS00360	COG0640	Transcriptional regulator
FHG54_RS00365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHG54_RS00370	COG0569	domain protein
FHG54_RS00390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHG54_RS00415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FHG54_RS00475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FHG54_RS00490	COG0167	dihydroorotate dehydrogenase activity
FHG54_RS00545	COG1316	TRANSCRIPTIONal
FHG54_RS00555	COG1316	TRANSCRIPTIONal
FHG54_RS00560	COG0561	phosphatase activity
FHG54_RS00565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FHG54_RS00570	COG1597	lipid kinase activity
FHG54_RS00580	COG1940	carbohydrate kinase activity
FHG54_RS00595	COG0077	Prephenate dehydratase
FHG54_RS00600	COG2733	membrane
FHG54_RS00620	COG0477	Major facilitator Superfamily
FHG54_RS00625	COG1876	peptidase activity
FHG54_RS00680	COG0084	hydrolase, TatD family'
FHG54_RS00695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FHG54_RS00700	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FHG54_RS00710	COG0095	Lipoate-protein ligase
FHG54_RS00740	COG2226	methyltransferase
FHG54_RS00765	COG1501	Belongs to the glycosyl hydrolase 31 family
FHG54_RS00780	COG1070	Carbohydrate kinase
FHG54_RS00785	COG1609	Transcriptional regulator
FHG54_RS00795	COG1132	(ABC) transporter
FHG54_RS00800	COG1132	(ABC) transporter
FHG54_RS00830	COG2814	Major facilitator Superfamily
FHG54_RS00835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHG54_RS00850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FHG54_RS00885	COG2340	Cysteine-rich secretory protein family
FHG54_RS00925	COG1216	Glycosyl transferase, family 2
FHG54_RS00930	COG3104	oligopeptide transport
FHG54_RS00945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FHG54_RS00950	COG1834	amidinotransferase
FHG54_RS00975	COG1725	Transcriptional regulator
FHG54_RS00980	COG0569	domain protein
FHG54_RS00980	COG0189	ligase activity
FHG54_RS00985	COG0189	ligase activity
FHG54_RS00985	COG4067	protein conserved in archaea
FHG54_RS00990	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS01015	COG0640	Transcriptional regulator
FHG54_RS01040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FHG54_RS01080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FHG54_RS01085	COG2079	MmgE PrpD family protein
FHG54_RS01095	COG1024	Enoyl-CoA hydratase
FHG54_RS01105	COG1054	Belongs to the UPF0176 family
FHG54_RS01120	COG3345	alpha-galactosidase
FHG54_RS01130	COG1131	(ABC) transporter
FHG54_RS01155	COG0300	oxidoreductase activity
FHG54_RS01170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FHG54_RS01175	COG0113	porphobilinogen synthase activity
FHG54_RS01185	COG0181	hydroxymethylbilane synthase activity
FHG54_RS01190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FHG54_RS01195	COG3253	May function as heme-dependent peroxidase
FHG54_RS01230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FHG54_RS01240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FHG54_RS01255	COG0423	glycine-tRNA ligase activity
FHG54_RS01260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FHG54_RS01265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FHG54_RS01275	COG0494	nUDIX hydrolase
FHG54_RS01295	COG3590	peptidase
FHG54_RS01300	COG0534	Mate efflux family protein
FHG54_RS01315	COG3559	Exporter of polyketide antibiotics
FHG54_RS01320	COG1131	(ABC) transporter
FHG54_RS01330	COG0156	8-amino-7-oxononanoate synthase activity
FHG54_RS01335	COG1063	alcohol dehydrogenase
FHG54_RS01340	COG0738	Major facilitator superfamily
FHG54_RS01350	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FHG54_RS01370	COG1309	transcriptional regulator
FHG54_RS01380	COG2197	response regulator
FHG54_RS01390	COG2837	iron assimilation
FHG54_RS01395	COG2822	iron ion transport
FHG54_RS01400	COG0672	)-iron permease
FHG54_RS01425	COG3718	enzyme involved in inositol metabolism
FHG54_RS01430	COG3962	Belongs to the TPP enzyme family
FHG54_RS01435	COG2188	Transcriptional regulator
FHG54_RS01450	COG3842	ATPase activity
FHG54_RS01455	COG0395	ABC-type sugar transport system, permease component
FHG54_RS01460	COG1175	transmembrane transport
FHG54_RS01470	COG0673	inositol 2-dehydrogenase activity
FHG54_RS01480	COG0640	Transcriptional regulator
FHG54_RS01490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHG54_RS01515	COG3591	Belongs to the peptidase S1B family
FHG54_RS01515	COG1864	DNA RNA non-specific endonuclease
FHG54_RS01530	COG0025	NhaP-type Na H and K H
FHG54_RS01540	COG0076	glutamate decarboxylase activity
FHG54_RS01555	COG2971	BadF BadG BcrA BcrD
FHG54_RS01570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHG54_RS01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHG54_RS01715	COG1716	ATPase activity
FHG54_RS01720	COG1716	ATPase activity
FHG54_RS01735	COG0768	penicillin binding
FHG54_RS01740	COG0515	serine threonine protein kinase
FHG54_RS01745	COG0515	serine threonine protein kinase
FHG54_RS01745	COG2815	serine threonine protein kinase
FHG54_RS01760	COG3764	Sortase (surface protein transpeptidase)
FHG54_RS01770	COG0705	Rhomboid family
FHG54_RS01770	COG0457	Tetratricopeptide repeat
FHG54_RS01835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FHG54_RS01840	COG0187	DNA topoisomerase II activity
FHG54_RS01845	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FHG54_RS01850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FHG54_RS01855	COG0592	DNA-directed DNA polymerase activity
FHG54_RS01860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FHG54_RS01865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FHG54_RS01870	COG0594	ribonuclease P activity
FHG54_RS01875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FHG54_RS01880	COG0706	membrane insertase activity
FHG54_RS01890	COG0357	Ribosomal RNA small subunit methyltransferase G
FHG54_RS01900	COG1192	Involved in chromosome partitioning
FHG54_RS01910	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHG54_RS01915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHG54_RS01920	COG3118	belongs to the thioredoxin family
FHG54_RS01925	COG0492	ferredoxin-NADP+ reductase activity
FHG54_RS01940	COG0617	tRNA 3'-terminal CCA addition
FHG54_RS01945	COG0360	Binds together with S18 to 16S ribosomal RNA
FHG54_RS01955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FHG54_RS01960	COG0359	binds to the 23S rRNA
FHG54_RS01965	COG0305	Participates in initiation and elongation during chromosome replication
FHG54_RS01970	COG2856	Zn peptidase
FHG54_RS01980	COG1484	DNA-dependent DNA replication
FHG54_RS02005	COG1609	Transcriptional regulator
FHG54_RS02010	COG1653	transport
FHG54_RS02015	COG1175	transmembrane transport
FHG54_RS02020	COG0395	ABC-type sugar transport system, permease component
FHG54_RS02030	COG3345	alpha-galactosidase
FHG54_RS02045	COG3507	Belongs to the glycosyl hydrolase 43 family
FHG54_RS02060	COG0673	inositol 2-dehydrogenase activity
FHG54_RS02075	COG1609	Transcriptional regulator
FHG54_RS02080	COG1929	Belongs to the glycerate kinase type-1 family
FHG54_RS02100	COG4115	mRNA cleavage
FHG54_RS02105	COG2249	NAD(P)H dehydrogenase (quinone) activity
FHG54_RS02115	COG2205	protein histidine kinase activity
FHG54_RS02155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHG54_RS02175	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FHG54_RS02180	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FHG54_RS02195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FHG54_RS02200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHG54_RS02220	COG1950	PFAM Membrane protein of
FHG54_RS02225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FHG54_RS02235	COG0022	dehydrogenase e1 component
FHG54_RS02240	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS02250	COG0803	Belongs to the bacterial solute-binding protein 9 family
FHG54_RS02255	COG1121	(ABC) transporter
FHG54_RS02265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FHG54_RS02275	COG0517	IMP dehydrogenase activity
FHG54_RS02275	COG4175	Glycine betaine
FHG54_RS02290	COG0076	glutamate decarboxylase activity
FHG54_RS02300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FHG54_RS02305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FHG54_RS02310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FHG54_RS02315	COG0776	regulation of translation
FHG54_RS02330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FHG54_RS02335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FHG54_RS02340	COG2197	response regulator
FHG54_RS02345	COG0586	Pfam SNARE associated Golgi protein
FHG54_RS02370	COG0717	Belongs to the dCTP deaminase family
FHG54_RS02420	COG2813	Specifically methylates the guanine in position
FHG54_RS02425	COG0443	Heat shock 70 kDa protein
FHG54_RS02430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FHG54_RS02435	COG0484	heat shock protein binding
FHG54_RS02440	COG0789	Transcriptional regulator
FHG54_RS02450	COG2813	Specifically methylates the guanine in position
FHG54_RS02455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FHG54_RS02470	COG0596	Alpha beta hydrolase
FHG54_RS02495	COG0628	permease
FHG54_RS02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FHG54_RS02560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS02565	COG2353	YceI-like domain
FHG54_RS02590	COG0542	response to heat
FHG54_RS02605	COG2272	Belongs to the type-B carboxylesterase lipase family
FHG54_RS02610	COG1063	alcohol dehydrogenase
FHG54_RS02630	COG4152	abc transporter atp-binding protein
FHG54_RS02645	COG0640	Transcriptional regulator
FHG54_RS02665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FHG54_RS02670	COG2197	response regulator
FHG54_RS02675	COG4585	Histidine kinase
FHG54_RS02690	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS02735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHG54_RS02760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FHG54_RS02765	COG4585	Histidine kinase
FHG54_RS02775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHG54_RS02790	COG0300	oxidoreductase activity
FHG54_RS02800	COG0515	serine threonine protein kinase
FHG54_RS02855	COG0778	Nitroreductase
FHG54_RS02855	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FHG54_RS02860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS02865	COG1920	GTP binding
FHG54_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS02915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FHG54_RS02920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHG54_RS02930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FHG54_RS02965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FHG54_RS02975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHG54_RS02980	COG1116	anion transmembrane transporter activity
FHG54_RS02985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHG54_RS02990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHG54_RS02995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FHG54_RS03015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FHG54_RS03025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHG54_RS03040	COG1017	nitric oxide dioxygenase activity
FHG54_RS03040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FHG54_RS03085	COG0598	Magnesium transport protein CorA
FHG54_RS03095	COG0137	argininosuccinate synthase activity
FHG54_RS03105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FHG54_RS03110	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FHG54_RS03125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHG54_RS03135	COG3279	Response regulator of the LytR AlgR family
FHG54_RS03140	COG3275	phosphorelay sensor kinase activity
FHG54_RS03150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHG54_RS03155	COG1725	Transcriptional regulator
FHG54_RS03160	COG1131	(ABC) transporter
FHG54_RS03170	COG1136	(ABC) transporter
FHG54_RS03180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FHG54_RS03185	COG0287	Prephenate dehydrogenase
FHG54_RS03185	COG1605	Chorismate mutase
FHG54_RS03255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHG54_RS03270	COG2814	Major facilitator Superfamily
FHG54_RS03280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHG54_RS03310	COG0047	phosphoribosylformylglycinamidine synthase activity
FHG54_RS03315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHG54_RS03335	COG3483	tryptophan 2,3-dioxygenase activity
FHG54_RS03340	COG3458	cephalosporin-C deacetylase activity
FHG54_RS03350	COG0747	negative chemotaxis
FHG54_RS03365	COG4608	Belongs to the ABC transporter superfamily
FHG54_RS03380	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FHG54_RS03390	COG2514	catechol 2,3-dioxygenase activity
FHG54_RS03395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FHG54_RS03400	COG0151	Belongs to the GarS family
FHG54_RS03405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FHG54_RS03415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FHG54_RS03420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHG54_RS03425	COG4558	Periplasmic binding protein
FHG54_RS03445	COG2050	protein possibly involved in aromatic compounds catabolism
FHG54_RS03455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FHG54_RS03475	COG3321	synthase
FHG54_RS03475	COG0604	alcohol dehydrogenase
FHG54_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS03485	COG4585	Histidine kinase
FHG54_RS03490	COG2197	response regulator
FHG54_RS03500	COG0531	amino acid
FHG54_RS03530	COG2364	Membrane
FHG54_RS03535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHG54_RS03545	COG0596	Alpha beta hydrolase
FHG54_RS03600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHG54_RS03605	COG4941	Belongs to the sigma-70 factor family
FHG54_RS03620	COG2217	Heavy metal translocating P-type atpase
FHG54_RS03640	COG1228	amidohydrolase
FHG54_RS03645	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FHG54_RS03650	COG0741	lytic transglycosylase activity
FHG54_RS03650	COG1196	nuclear chromosome segregation
FHG54_RS03650	COG0739	heme binding
FHG54_RS03665	COG0586	Pfam SNARE associated Golgi protein
FHG54_RS03685	COG2197	response regulator
FHG54_RS03690	COG4585	Histidine kinase
FHG54_RS03695	COG1295	ribonuclease BN
FHG54_RS03710	COG0513	Belongs to the DEAD box helicase family
FHG54_RS03715	COG0183	Belongs to the thiolase family
FHG54_RS03720	COG1024	Enoyl-CoA hydratase
FHG54_RS03725	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHG54_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS03730	COG2030	dehydratase
FHG54_RS03740	COG0514	ATP-dependent DNA helicase (RecQ)
FHG54_RS03760	COG2197	response regulator
FHG54_RS03765	COG1309	transcriptional regulator
FHG54_RS03775	COG2050	protein possibly involved in aromatic compounds catabolism
FHG54_RS03780	COG3396	Phenylacetate-CoA oxygenase
FHG54_RS03785	COG3460	Phenylacetate-CoA oxygenase
FHG54_RS03790	COG3396	Phenylacetate-CoA oxygenase
FHG54_RS03795	COG2151	metal-sulfur cluster biosynthetic enzyme
FHG54_RS03800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FHG54_RS03810	COG1320	monovalent cation:proton antiporter activity
FHG54_RS03825	COG0651	ATP synthesis coupled electron transport
FHG54_RS03830	COG1006	Multisubunit Na H antiporter MnhC subunit
FHG54_RS03835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FHG54_RS03835	COG2111	Na H antiporter
FHG54_RS03875	COG0640	Transcriptional regulator
FHG54_RS03885	COG0545	Peptidyl-prolyl cis-trans isomerase
FHG54_RS03910	COG5441	Belongs to the UPF0261 family
FHG54_RS03920	COG0583	DNA-binding transcription factor activity
FHG54_RS03925	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FHG54_RS03930	COG1122	ATPase activity
FHG54_RS03940	COG3119	arylsulfatase activity
FHG54_RS03945	COG0628	permease
FHG54_RS03950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS04005	COG2957	Belongs to the agmatine deiminase family
FHG54_RS04010	COG0154	amidase activity
FHG54_RS04035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FHG54_RS04065	COG1063	alcohol dehydrogenase
FHG54_RS04080	COG0702	epimerase
FHG54_RS04085	COG2130	NADP-dependent
FHG54_RS04095	COG0789	Transcriptional regulator
FHG54_RS04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHG54_RS04135	COG1846	Transcriptional regulator
FHG54_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS04145	COG4129	membrane
FHG54_RS04155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHG54_RS04180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHG54_RS04185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FHG54_RS04205	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
FHG54_RS04215	COG3012	SEC-C Motif Domain Protein
FHG54_RS04280	COG0513	Belongs to the DEAD box helicase family
FHG54_RS04285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHG54_RS04295	COG1201	RNA secondary structure unwinding
FHG54_RS04300	COG0210	DNA helicase
FHG54_RS04320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FHG54_RS04415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FHG54_RS04430	COG4585	Histidine kinase
FHG54_RS04485	COG1960	acyl-CoA dehydrogenase activity
FHG54_RS04510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FHG54_RS04530	COG1278	Cold shock
FHG54_RS04535	COG1278	Cold shock
FHG54_RS04550	COG0640	Transcriptional regulator
FHG54_RS04575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FHG54_RS04600	COG0737	Belongs to the 5'-nucleotidase family
FHG54_RS04605	COG4085	toxin activity
FHG54_RS04605	COG0737	Belongs to the 5'-nucleotidase family
FHG54_RS04605	COG1525	nuclease
FHG54_RS04610	COG0514	ATP-dependent DNA helicase (RecQ)
FHG54_RS04615	COG1695	Transcriptional regulator
FHG54_RS04665	COG0039	L-malate dehydrogenase activity
FHG54_RS04690	COG0697	spore germination
FHG54_RS04705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FHG54_RS04705	COG1796	DNA polymerase
FHG54_RS04710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHG54_RS04880	COG0515	serine threonine protein kinase
FHG54_RS04880	COG2815	serine threonine protein kinase
FHG54_RS04930	COG1196	nuclear chromosome segregation
FHG54_RS04930	COG0741	lytic transglycosylase activity
FHG54_RS04930	COG0739	heme binding
FHG54_RS04940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FHG54_RS04955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHG54_RS04965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FHG54_RS04970	COG0302	gtp cyclohydrolase
FHG54_RS04975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FHG54_RS04980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FHG54_RS05020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FHG54_RS05025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FHG54_RS05030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHG54_RS05050	COG3655	Transcriptional regulator
FHG54_RS05065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FHG54_RS05085	COG0436	Aminotransferase
FHG54_RS05095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FHG54_RS05100	COG2072	flavoprotein involved in K transport
FHG54_RS05120	COG3177	Filamentation induced by cAMP protein fic
FHG54_RS05140	COG2261	transglycosylase associated protein
FHG54_RS05145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHG54_RS05145	COG0519	Catalyzes the synthesis of GMP from XMP
FHG54_RS05185	COG0513	Belongs to the DEAD box helicase family
FHG54_RS05220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FHG54_RS05230	COG1984	allophanate hydrolase subunit 2
FHG54_RS05235	COG2197	response regulator
FHG54_RS05240	COG4585	Histidine kinase
FHG54_RS05260	COG0085	RNA polymerase activity
FHG54_RS05265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FHG54_RS05370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FHG54_RS05375	COG0049	tRNA binding
FHG54_RS05380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FHG54_RS05385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FHG54_RS05390	COG2755	lipolytic protein G-D-S-L family
FHG54_RS05390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FHG54_RS05400	COG0051	transcription antitermination factor activity, RNA binding
FHG54_RS05405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FHG54_RS05410	COG0088	Forms part of the polypeptide exit tunnel
FHG54_RS05415	COG0089	rRNA binding
FHG54_RS05420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FHG54_RS05425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FHG54_RS05430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FHG54_RS05435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FHG54_RS05440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FHG54_RS05445	COG0255	Belongs to the universal ribosomal protein uL29 family
FHG54_RS05450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FHG54_RS05455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FHG54_RS05460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FHG54_RS05465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FHG54_RS05470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FHG54_RS05475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FHG54_RS05480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FHG54_RS05485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FHG54_RS05490	COG1841	ribosomal large subunit assembly
FHG54_RS05495	COG0200	Binds to the 23S rRNA
FHG54_RS05500	COG0201	protein transport
FHG54_RS05505	COG0563	adenylate kinase activity
FHG54_RS05530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FHG54_RS05540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHG54_RS05545	COG0246	Mannitol dehydrogenase
FHG54_RS05550	COG2197	response regulator
FHG54_RS05555	COG4585	Histidine kinase
FHG54_RS05565	COG2132	Multicopper oxidase
FHG54_RS05570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FHG54_RS05580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FHG54_RS05585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FHG54_RS05590	COG0202	RNA polymerase activity
FHG54_RS05595	COG0203	ribosomal protein L17
FHG54_RS05600	COG0101	tRNA pseudouridine synthase activity
FHG54_RS05610	COG1309	transcriptional regulator
FHG54_RS05615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FHG54_RS05620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FHG54_RS05625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHG54_RS05630	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FHG54_RS05630	COG3291	Pkd domain containing protein
FHG54_RS05635	COG1072	(Pantothenic acid kinase))
FHG54_RS05640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHG54_RS05645	COG0736	holo-[acyl-carrier-protein] synthase activity
FHG54_RS05650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FHG54_RS05655	COG0802	atpase or kinase
FHG54_RS05665	COG0456	acetyltransferase
FHG54_RS05670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FHG54_RS05695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FHG54_RS05740	COG0488	(ABC) transporter
FHG54_RS05745	COG0516	GMP reductase activity
FHG54_RS05750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FHG54_RS05770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHG54_RS05770	COG0519	Catalyzes the synthesis of GMP from XMP
FHG54_RS05780	COG0584	glycerophosphoryl diester phosphodiesterase
FHG54_RS05805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FHG54_RS05820	COG2211	Major facilitator Superfamily
FHG54_RS05835	COG1131	(ABC) transporter
FHG54_RS05845	COG1476	TRANSCRIPTIONal
FHG54_RS05850	COG0045	succinate-CoA ligase (ADP-forming) activity
FHG54_RS05895	COG0138	bifunctional purine biosynthesis protein purh
FHG54_RS05905	COG1834	amidinotransferase
FHG54_RS05910	COG1136	(ABC) transporter
FHG54_RS05935	COG1132	(ABC) transporter
FHG54_RS05940	COG2197	response regulator
FHG54_RS05970	COG1309	transcriptional regulator
FHG54_RS06000	COG0395	ABC-type sugar transport system, permease component
FHG54_RS06005	COG1472	Belongs to the glycosyl hydrolase 3 family
FHG54_RS06050	COG0191	fructose-bisphosphate aldolase activity
FHG54_RS06055	COG1105	Belongs to the carbohydrate kinase PfkB family
FHG54_RS06060	COG1940	carbohydrate kinase activity
FHG54_RS06065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHG54_RS06080	COG0395	ABC-type sugar transport system, permease component
FHG54_RS06095	COG1175	transmembrane transport
FHG54_RS06115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FHG54_RS06120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FHG54_RS06125	COG1083	cytidylyl-transferase
FHG54_RS06130	COG2089	acid synthase
FHG54_RS06160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FHG54_RS06170	COG1349	DNA-binding transcription factor activity
FHG54_RS06175	COG2017	converts alpha-aldose to the beta-anomer
FHG54_RS06195	COG1595	DNA-templated transcription, initiation
FHG54_RS06205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS06220	COG2197	response regulator
FHG54_RS06235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FHG54_RS06245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FHG54_RS06290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHG54_RS06315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FHG54_RS06320	COG0745	RESPONSE REGULATOR receiver
FHG54_RS06330	COG3485	protocatechuate 3,4-dioxygenase
FHG54_RS06350	COG0588	phosphoglycerate mutase activity
FHG54_RS06360	COG5002	protein histidine kinase activity
FHG54_RS06365	COG0745	RESPONSE REGULATOR receiver
FHG54_RS06380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FHG54_RS06380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FHG54_RS06385	COG0215	cysteine-tRNA ligase activity
FHG54_RS06390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHG54_RS06400	COG3842	ATPase activity
FHG54_RS06425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHG54_RS06440	COG1278	Cold shock
FHG54_RS06445	COG1470	cell adhesion involved in biofilm formation
FHG54_RS06450	COG0459	protein refolding
FHG54_RS06455	COG2814	Major facilitator Superfamily
FHG54_RS06475	COG1140	nitrate reductase beta subunit
FHG54_RS06490	COG0315	cyclic pyranopterin monophosphate synthase activity
FHG54_RS06490	COG0521	Mo-molybdopterin cofactor biosynthetic process
FHG54_RS06495	COG0746	molybdenum cofactor guanylyltransferase activity
FHG54_RS06500	COG0315	cyclic pyranopterin monophosphate synthase activity
FHG54_RS06535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FHG54_RS06560	COG0590	tRNA wobble adenosine to inosine editing
FHG54_RS06570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FHG54_RS06585	COG3257	ureidoglycine aminohydrolase activity
FHG54_RS06590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FHG54_RS06620	COG4948	Mandelate Racemase Muconate Lactonizing
FHG54_RS06640	COG0433	COG0433 Predicted ATPase
FHG54_RS06665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FHG54_RS06685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FHG54_RS06695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FHG54_RS06735	COG0579	oxidoreductase
FHG54_RS06740	COG0488	(ABC) transporter
FHG54_RS06745	COG0477	Major facilitator Superfamily
FHG54_RS06795	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FHG54_RS06815	COG3409	Peptidoglycan-binding domain 1 protein
FHG54_RS06870	COG1408	metallophosphoesterase
FHG54_RS06875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHG54_RS06900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FHG54_RS06935	COG1754	DNA topoisomerase type I activity
FHG54_RS06935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FHG54_RS06940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FHG54_RS06945	COG0470	DNA polymerase III
FHG54_RS06960	COG1733	regulation of RNA biosynthetic process
FHG54_RS06990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FHG54_RS06990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FHG54_RS07010	COG1335	isochorismatase
FHG54_RS07035	COG1802	Transcriptional regulator
FHG54_RS07040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FHG54_RS07050	COG3971	2-oxopent-4-enoate hydratase activity
FHG54_RS07055	COG1268	BioY protein
FHG54_RS07070	COG0183	Belongs to the thiolase family
FHG54_RS07095	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FHG54_RS07110	COG1132	(ABC) transporter
FHG54_RS07125	COG2313	pseudouridylate synthase activity
FHG54_RS07140	COG0175	sulfate reduction
FHG54_RS07160	COG1116	anion transmembrane transporter activity
FHG54_RS07165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHG54_RS07170	COG1648	precorrin-2 dehydrogenase activity
FHG54_RS07170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FHG54_RS07195	COG0477	Major facilitator Superfamily
FHG54_RS07205	COG2211	Major facilitator Superfamily
FHG54_RS07210	COG3345	alpha-galactosidase
FHG54_RS07215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FHG54_RS07220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FHG54_RS07220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FHG54_RS07235	COG2390	Transcriptional regulator
FHG54_RS07245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FHG54_RS07250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FHG54_RS07255	COG1011	Hydrolase
FHG54_RS07265	COG0180	Tryptophanyl-tRNA synthetase
FHG54_RS07280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FHG54_RS07295	COG2009	succinate dehydrogenase
FHG54_RS07305	COG1744	ABC transporter substrate-binding protein PnrA-like
FHG54_RS07330	COG3845	ABC transporter
FHG54_RS07335	COG4603	Belongs to the binding-protein-dependent transport system permease family
FHG54_RS07340	COG1079	Belongs to the binding-protein-dependent transport system permease family
FHG54_RS07355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FHG54_RS07360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHG54_RS07370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHG54_RS07385	COG0531	amino acid
FHG54_RS07395	COG4770	biotin carboxylase activity
FHG54_RS07400	COG0424	maF-like protein
FHG54_RS07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHG54_RS07430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FHG54_RS07465	COG1316	TRANSCRIPTIONal
FHG54_RS07475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHG54_RS07525	COG1216	Glycosyl transferase, family 2
FHG54_RS07525	COG0438	transferase activity, transferring glycosyl groups
FHG54_RS07530	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FHG54_RS07570	COG0579	oxidoreductase
FHG54_RS07575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHG54_RS07580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHG54_RS07595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHG54_RS07610	COG1215	transferase activity, transferring glycosyl groups
FHG54_RS07625	COG1482	cell wall glycoprotein biosynthetic process
FHG54_RS07665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHG54_RS07670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FHG54_RS07695	COG0714	Associated with various cellular activities
FHG54_RS07715	COG0745	RESPONSE REGULATOR receiver
FHG54_RS07720	COG5000	phosphorelay sensor kinase activity
FHG54_RS07720	COG5002	protein histidine kinase activity
FHG54_RS07725	COG5401	PFAM Sporulation and spore germination
FHG54_RS07730	COG1040	competence protein
FHG54_RS07735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FHG54_RS07740	COG0653	protein targeting
FHG54_RS07790	COG0586	Pfam SNARE associated Golgi protein
FHG54_RS07840	COG3387	PFAM Glycoside hydrolase 15-related
FHG54_RS07890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FHG54_RS07900	COG2177	Part of the ABC transporter FtsEX involved in
FHG54_RS07905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FHG54_RS07930	COG0483	inositol monophosphate 1-phosphatase activity
FHG54_RS07940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FHG54_RS07945	COG1122	ATPase activity
FHG54_RS07950	COG1268	BioY protein
FHG54_RS07975	COG1511	domain protein
FHG54_RS07985	COG0129	dihydroxy-acid dehydratase activity
FHG54_RS07990	COG0028	Belongs to the TPP enzyme family
FHG54_RS07995	COG0440	acetolactate synthase activity
FHG54_RS08000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FHG54_RS08005	COG3142	Participates in the control of copper homeostasis
FHG54_RS08035	COG0477	Major facilitator Superfamily
FHG54_RS08045	COG0473	3-isopropylmalate dehydrogenase activity
FHG54_RS08070	COG0179	Fumarylacetoacetate (FAA) hydrolase
FHG54_RS08105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FHG54_RS08160	COG3119	arylsulfatase activity
FHG54_RS08165	COG0631	protein serine/threonine phosphatase activity
FHG54_RS08175	COG0515	serine threonine protein kinase
FHG54_RS08190	COG0714	Associated with various cellular activities
FHG54_RS08210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FHG54_RS08215	COG0066	3-isopropylmalate dehydratase activity
FHG54_RS08220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FHG54_RS08225	COG0318	PFAM AMP-dependent synthetase and ligase
FHG54_RS08225	COG0204	Acyl-transferase
FHG54_RS08230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FHG54_RS08235	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHG54_RS08250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FHG54_RS08255	COG0277	FAD linked oxidase domain protein
FHG54_RS08255	COG0247	lactate metabolic process
FHG54_RS08270	COG0006	proline dipeptidase activity
FHG54_RS08275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHG54_RS08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHG54_RS08300	COG0765	amino acid transport
FHG54_RS08305	COG0765	amino acid transport
FHG54_RS08310	COG1126	abc transporter atp-binding protein
FHG54_RS08335	COG0742	ribosomal rna small subunit methyltransferase
FHG54_RS08345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FHG54_RS08350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FHG54_RS08355	COG0714	Associated with various cellular activities
FHG54_RS08375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FHG54_RS08380	COG0571	ribonuclease III activity
FHG54_RS08385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHG54_RS08430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHG54_RS08440	COG1196	nuclear chromosome segregation
FHG54_RS08465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FHG54_RS08470	COG0228	four-way junction DNA binding
FHG54_RS08475	COG1837	Belongs to the UPF0109 family
FHG54_RS08480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FHG54_RS08485	COG0336	Belongs to the RNA methyltransferase TrmD family
FHG54_RS08495	COG0243	molybdopterin cofactor binding
FHG54_RS08500	COG2223	nitrite transmembrane transporter activity
FHG54_RS08510	COG1648	precorrin-2 dehydrogenase activity
FHG54_RS08510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FHG54_RS08535	COG0335	large ribosomal subunit rRNA binding
FHG54_RS08540	COG0681	Belongs to the peptidase S26 family
FHG54_RS08545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FHG54_RS08555	COG0792	nuclease activity
FHG54_RS08570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FHG54_RS08575	COG4974	Belongs to the 'phage' integrase family
FHG54_RS08585	COG0052	Belongs to the universal ribosomal protein uS2 family
FHG54_RS08590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FHG54_RS08595	COG0528	UMP kinase activity
FHG54_RS08600	COG0233	cytoplasmic translational termination
FHG54_RS08650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FHG54_RS08655	COG0366	Alpha amylase catalytic
FHG54_RS08660	COG0058	SHG alpha-glucan phosphorylase activity
FHG54_RS08680	COG0482	sulfurtransferase activity
FHG54_RS08690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FHG54_RS08700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHG54_RS08705	COG0154	amidase activity
FHG54_RS08710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHG54_RS08720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHG54_RS08725	COG4721	ABC-type cobalt transport system, permease component
FHG54_RS08730	COG1122	ATPase activity
FHG54_RS08765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FHG54_RS08775	COG0475	glutathione-regulated potassium exporter activity
FHG54_RS08780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FHG54_RS08795	COG0667	Aldo Keto reductase
FHG54_RS08800	COG0629	single-stranded DNA binding
FHG54_RS08830	COG1946	Acyl-CoA thioesterase
FHG54_RS08850	COG0668	transmembrane transport
FHG54_RS08860	COG2197	response regulator
FHG54_RS08865	COG4585	Histidine kinase
FHG54_RS08915	COG3177	Filamentation induced by cAMP protein fic
FHG54_RS08925	COG2197	response regulator
FHG54_RS08935	COG0783	Belongs to the Dps family
FHG54_RS08960	COG0544	peptidyl-prolyl cis-trans isomerase activity
FHG54_RS08970	COG0740	serine-type endopeptidase activity
FHG54_RS08975	COG0740	serine-type endopeptidase activity
FHG54_RS08980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FHG54_RS08985	COG3135	benzoate transporter
FHG54_RS09005	COG0756	dUTP diphosphatase activity
FHG54_RS09020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FHG54_RS09025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FHG54_RS09040	COG1024	Enoyl-CoA hydratase
FHG54_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHG54_RS09045	COG0183	Belongs to the thiolase family
FHG54_RS09050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FHG54_RS09120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FHG54_RS09130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FHG54_RS09140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FHG54_RS09145	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FHG54_RS09160	COG0217	transcriptional regulatory protein
FHG54_RS09165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FHG54_RS09170	COG0632	four-way junction helicase activity
FHG54_RS09175	COG2255	four-way junction helicase activity
FHG54_RS09185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FHG54_RS09190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FHG54_RS09195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHG54_RS09205	COG1196	nuclear chromosome segregation
FHG54_RS09220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FHG54_RS09230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FHG54_RS09235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FHG54_RS09245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FHG54_RS09250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FHG54_RS09255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FHG54_RS09260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FHG54_RS09265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FHG54_RS09270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FHG54_RS09275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FHG54_RS09295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FHG54_RS09300	COG0540	Belongs to the ATCase OTCase family
FHG54_RS09305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FHG54_RS09315	COG0505	Belongs to the CarA family
FHG54_RS09320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FHG54_RS09325	COG0284	orotidine-5'-phosphate decarboxylase activity
FHG54_RS09330	COG0194	GDP metabolic process
FHG54_RS09335	COG1758	RNA polymerase activity
FHG54_RS09345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FHG54_RS09355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FHG54_RS09365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FHG54_RS09370	COG0140	phosphoribosyl-ATP diphosphatase activity
FHG54_RS09375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FHG54_RS09380	COG0107	imidazoleglycerol-phosphate synthase activity
FHG54_RS09385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FHG54_RS09405	COG0134	indole-3-glycerol-phosphate synthase activity
FHG54_RS09410	COG0133	tryptophan synthase activity
FHG54_RS09415	COG0159	tryptophan synthase activity
FHG54_RS09420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FHG54_RS09425	COG0067	glutamate synthase
FHG54_RS09425	COG0070	glutamate synthase
FHG54_RS09425	COG0069	glutamate synthase activity
FHG54_RS09470	COG0237	dephospho-CoA kinase activity
FHG54_RS09475	COG0556	nucleotide-excision repair
FHG54_RS09485	COG0322	excinuclease ABC activity
FHG54_RS09490	COG1660	Displays ATPase and GTPase activities
FHG54_RS09495	COG1481	regulation of sporulation
FHG54_RS09510	COG0126	phosphoglycerate kinase activity
FHG54_RS09515	COG0149	triose-phosphate isomerase activity
FHG54_RS09520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FHG54_RS09530	COG0363	glucosamine-6-phosphate deaminase activity
FHG54_RS09545	COG0166	Belongs to the GPI family
FHG54_RS09550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FHG54_RS09560	COG0109	protoheme IX farnesyltransferase activity
FHG54_RS09565	COG2197	response regulator
FHG54_RS09570	COG1612	heme a metabolic process
FHG54_RS09590	COG0396	ATPase activity
FHG54_RS09595	COG2151	metal-sulfur cluster biosynthetic enzyme
FHG54_RS09600	COG0339	signal peptide processing
FHG54_RS09605	COG2226	methyltransferase
FHG54_RS09625	COG0525	valine-tRNA ligase activity
FHG54_RS09635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHG54_RS09645	COG0747	negative chemotaxis
FHG54_RS09650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHG54_RS09655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FHG54_RS09660	COG0285	dihydrofolate synthase activity
FHG54_RS09670	COG0105	UTP biosynthetic process
FHG54_RS09680	COG1530	ribonuclease E activity
FHG54_RS09690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FHG54_RS09695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FHG54_RS09700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FHG54_RS09705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FHG54_RS09710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FHG54_RS09720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FHG54_RS09730	COG0799	negative regulation of ribosome biogenesis
FHG54_RS09800	COG1309	transcriptional regulator
FHG54_RS09805	COG0386	Belongs to the glutathione peroxidase family
FHG54_RS09815	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS09820	COG0022	dehydrogenase e1 component
FHG54_RS09845	COG1472	Belongs to the glycosyl hydrolase 3 family
FHG54_RS09860	COG0488	(ABC) transporter
FHG54_RS09900	COG0560	Phosphoserine phosphatase
FHG54_RS09905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FHG54_RS09910	COG0297	glycogen (starch) synthase activity
FHG54_RS09915	COG1119	ATPase activity
FHG54_RS09920	COG0254	rRNA binding
FHG54_RS09950	COG1686	Belongs to the peptidase S11 family
FHG54_RS09965	COG0477	Major facilitator Superfamily
FHG54_RS09970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FHG54_RS09970	COG1017	nitric oxide dioxygenase activity
FHG54_RS09975	COG0626	cystathionine gamma-synthase activity
FHG54_RS10005	COG0587	DNA-directed DNA polymerase activity
FHG54_RS10035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHG54_RS10040	COG1968	undecaprenyl-diphosphatase activity
FHG54_RS10050	COG0546	phosphoglycolate phosphatase activity
FHG54_RS10075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FHG54_RS10080	COG0805	protein transport
FHG54_RS10085	COG4581	dead DEAH box helicase
FHG54_RS10100	COG0584	glycerophosphoryl diester phosphodiesterase
FHG54_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS10195	COG2376	Dihydroxyacetone kinase
FHG54_RS10200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FHG54_RS10210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FHG54_RS10215	COG1845	cytochrome c oxidase, subunit III
FHG54_RS10220	COG2010	Cytochrome c
FHG54_RS10225	COG0723	plastoquinol--plastocyanin reductase activity
FHG54_RS10230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FHG54_RS10235	COG2226	methyltransferase
FHG54_RS10245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FHG54_RS10250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FHG54_RS10260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHG54_RS10275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FHG54_RS10285	COG0187	DNA topoisomerase II activity
FHG54_RS10305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FHG54_RS10315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FHG54_RS10320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHG54_RS10325	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS10335	COG0321	lipoyl(octanoyl) transferase activity
FHG54_RS10340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FHG54_RS10355	COG0174	glutamine synthetase
FHG54_RS10360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FHG54_RS10370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FHG54_RS10405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FHG54_RS10430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FHG54_RS10440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FHG54_RS10445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FHG54_RS10450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHG54_RS10455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FHG54_RS10500	COG2072	flavoprotein involved in K transport
FHG54_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS10530	COG2211	Major facilitator Superfamily
FHG54_RS10545	COG2211	Major facilitator Superfamily
FHG54_RS10565	COG0473	3-isopropylmalate dehydrogenase activity
FHG54_RS10565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FHG54_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS10655	COG0582	viral genome integration into host DNA
FHG54_RS10670	COG0438	transferase activity, transferring glycosyl groups
FHG54_RS10680	COG0242	peptide deformylase activity
FHG54_RS10700	COG4608	Belongs to the ABC transporter superfamily
FHG54_RS10710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHG54_RS10715	COG0601	transmembrane transport
FHG54_RS10720	COG0747	negative chemotaxis
FHG54_RS10725	COG0358	DNA primase activity
FHG54_RS10730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FHG54_RS10740	COG0442	prolyl-tRNA aminoacylation
FHG54_RS10750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FHG54_RS10755	COG1381	Involved in DNA repair and RecF pathway recombination
FHG54_RS10760	COG2860	membrane
FHG54_RS10765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FHG54_RS10770	COG0577	efflux transmembrane transporter activity
FHG54_RS10775	COG1136	(ABC) transporter
FHG54_RS10780	COG2197	response regulator
FHG54_RS10785	COG4585	Histidine kinase
FHG54_RS10790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FHG54_RS10800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FHG54_RS10810	COG0537	adenosine 5'-monophosphoramidase activity
FHG54_RS10820	COG0484	heat shock protein binding
FHG54_RS10825	COG1420	regulation of RNA biosynthetic process
FHG54_RS10845	COG4762	Protein conserved in bacteria
FHG54_RS10850	COG0481	GTPase activity
FHG54_RS10860	COG0268	Binds directly to 16S ribosomal RNA
FHG54_RS10885	COG0495	leucyl-tRNA aminoacylation
FHG54_RS10895	COG1132	(ABC) transporter
FHG54_RS10900	COG4988	ABC transporter
FHG54_RS10905	COG1294	oxidase, subunit
FHG54_RS10910	COG1271	oxidase subunit
FHG54_RS10925	COG0586	Pfam SNARE associated Golgi protein
FHG54_RS10930	COG1732	Glycine betaine
FHG54_RS10940	COG1174	glycine betaine transport
FHG54_RS10960	COG0167	dihydroorotate dehydrogenase activity
FHG54_RS10965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FHG54_RS10970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FHG54_RS10985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FHG54_RS11000	COG1799	cell septum assembly
FHG54_RS11010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FHG54_RS11020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FHG54_RS11025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FHG54_RS11030	COG0772	Belongs to the SEDS family
FHG54_RS11035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FHG54_RS11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHG54_RS11050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FHG54_RS11055	COG0768	penicillin binding
FHG54_RS11070	COG0275	rRNA processing
FHG54_RS11075	COG2001	Belongs to the MraZ family
FHG54_RS11085	COG0142	geranyltranstransferase activity
FHG54_RS11095	COG3942	CHAP domain
FHG54_RS11095	COG1388	LysM domain
FHG54_RS11100	COG0515	serine threonine protein kinase
FHG54_RS11100	COG2815	serine threonine protein kinase
FHG54_RS11105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FHG54_RS11115	COG1940	carbohydrate kinase activity
FHG54_RS11135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FHG54_RS11140	COG1192	Involved in chromosome partitioning
FHG54_RS11190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FHG54_RS11205	COG2357	RelA SpoT domain protein
FHG54_RS11240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHG54_RS11270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHG54_RS11275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHG54_RS11305	COG0028	Belongs to the TPP enzyme family
FHG54_RS11325	COG1160	GTP binding
FHG54_RS11330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FHG54_RS11345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FHG54_RS11350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FHG54_RS11365	COG0494	nUDIX hydrolase
FHG54_RS11370	COG0504	CTP synthase activity
FHG54_RS11375	COG0497	DNA recombination
FHG54_RS11380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FHG54_RS11395	COG1011	Hydrolase
FHG54_RS11425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FHG54_RS11440	COG2094	Belongs to the DNA glycosylase MPG family
FHG54_RS11445	COG0165	Argininosuccinate lyase
FHG54_RS11450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FHG54_RS11460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FHG54_RS11465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FHG54_RS11470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FHG54_RS11475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHG54_RS11475	COG0072	phenylalanine-tRNA ligase activity
FHG54_RS11480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FHG54_RS11485	COG0765	amino acid transport
FHG54_RS11490	COG0765	amino acid transport
FHG54_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHG54_RS11500	COG1126	abc transporter atp-binding protein
FHG54_RS11505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHG54_RS11510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FHG54_RS11515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FHG54_RS11520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FHG54_RS11530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHG54_RS11535	COG1201	RNA secondary structure unwinding
FHG54_RS11550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FHG54_RS11555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FHG54_RS11560	COG0131	Imidazoleglycerol-phosphate dehydratase
FHG54_RS11565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FHG54_RS11575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHG54_RS11580	COG2267	carboxylic ester hydrolase activity
FHG54_RS11595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FHG54_RS11600	COG2813	Specifically methylates the guanine in position
FHG54_RS11605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FHG54_RS11610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FHG54_RS11615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FHG54_RS11625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FHG54_RS11635	COG1396	sequence-specific DNA binding
FHG54_RS11640	COG1546	Belongs to the CinA family
FHG54_RS11640	COG1058	Belongs to the CinA family
FHG54_RS11650	COG1674	ftsk spoiiie
FHG54_RS11655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FHG54_RS11660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FHG54_RS11670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FHG54_RS11680	COG1090	epimerase
FHG54_RS11690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FHG54_RS11700	COG2062	phosphohistidine phosphatase, SixA
FHG54_RS11705	COG0612	Peptidase, M16
FHG54_RS11710	COG0667	Aldo Keto reductase
FHG54_RS11725	COG1960	acyl-CoA dehydrogenase activity
FHG54_RS11740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FHG54_RS11745	COG1309	transcriptional regulator
FHG54_RS11755	COG2154	pterin-4-alpha-carbinolamine dehydratase
FHG54_RS11760	COG1063	alcohol dehydrogenase
FHG54_RS11765	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS11770	COG0022	dehydrogenase e1 component
FHG54_RS11805	COG1185	polyribonucleotide nucleotidyltransferase activity
FHG54_RS11835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS11845	COG1216	Glycosyl transferase, family 2
FHG54_RS11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHG54_RS11885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FHG54_RS11890	COG0604	alcohol dehydrogenase
FHG54_RS11900	COG3189	MarR family transcriptional regulator
FHG54_RS11950	COG0545	Peptidyl-prolyl cis-trans isomerase
FHG54_RS11960	COG0277	FAD linked oxidase domain protein
FHG54_RS11970	COG0179	Fumarylacetoacetate (FAA) hydrolase
FHG54_RS11985	COG2252	PERMEase
FHG54_RS12000	COG1051	belongs to the nudix hydrolase family
FHG54_RS12010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHG54_RS12025	COG1937	Protein conserved in bacteria
FHG54_RS12055	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS12060	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS12065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FHG54_RS12070	COG2390	Transcriptional regulator
FHG54_RS12080	COG0196	riboflavin kinase activity
FHG54_RS12095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FHG54_RS12125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FHG54_RS12145	COG1194	a g-specific adenine glycosylase
FHG54_RS12150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FHG54_RS12155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FHG54_RS12180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FHG54_RS12205	COG2267	carboxylic ester hydrolase activity
FHG54_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS12235	COG0318	PFAM AMP-dependent synthetase and ligase
FHG54_RS12255	COG1137	ATPase activity
FHG54_RS12265	COG0183	Belongs to the thiolase family
FHG54_RS12275	COG1309	transcriptional regulator
FHG54_RS12285	COG2197	response regulator
FHG54_RS12290	COG4585	Histidine kinase
FHG54_RS12295	COG0750	zinc metalloprotease
FHG54_RS12300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FHG54_RS12310	COG0318	PFAM AMP-dependent synthetase and ligase
FHG54_RS12310	COG0204	Acyl-transferase
FHG54_RS12325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FHG54_RS12355	COG0714	Associated with various cellular activities
FHG54_RS12370	COG0631	protein serine/threonine phosphatase activity
FHG54_RS12385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FHG54_RS12395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FHG54_RS12400	COG2818	Glycosylase
FHG54_RS12415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FHG54_RS12420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FHG54_RS12425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FHG54_RS12430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FHG54_RS12435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHG54_RS12440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FHG54_RS12445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHG54_RS12450	COG0356	it plays a direct role in the translocation of protons across the membrane
FHG54_RS12460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHG54_RS12485	COG2890	protein-(glutamine-N5) methyltransferase activity
FHG54_RS12495	COG1045	serine acetyltransferase
FHG54_RS12500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FHG54_RS12510	COG0083	homoserine kinase activity
FHG54_RS12520	COG0460	homoserine dehydrogenase
FHG54_RS12525	COG0019	diaminopimelate decarboxylase activity
FHG54_RS12535	COG0018	arginyl-trna synthetase
FHG54_RS12560	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FHG54_RS12565	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHG54_RS12580	COG1842	Phage shock protein A
FHG54_RS12585	COG0010	Belongs to the arginase family
FHG54_RS12590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHG54_RS12615	COG1120	ATPase activity
FHG54_RS12635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FHG54_RS12645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FHG54_RS12650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FHG54_RS12670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHG54_RS12690	COG2814	Major facilitator Superfamily
FHG54_RS12710	COG1011	Hydrolase
FHG54_RS12735	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS12735	COG0567	Dehydrogenase, E1 component
FHG54_RS12740	COG2409	Drug exporters of the RND superfamily
FHG54_RS12750	COG1595	DNA-templated transcription, initiation
FHG54_RS12755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FHG54_RS12780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FHG54_RS12785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FHG54_RS12790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FHG54_RS12880	COG1215	transferase activity, transferring glycosyl groups
FHG54_RS12885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHG54_RS12895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FHG54_RS12915	COG0628	permease
FHG54_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS12950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FHG54_RS12955	COG1615	UPF0182 protein
FHG54_RS12960	COG3480	Lon protease (S16) C-terminal proteolytic domain
FHG54_RS12975	COG2816	NAD+ diphosphatase activity
FHG54_RS12985	COG0210	DNA helicase
FHG54_RS13010	COG0513	Belongs to the DEAD box helicase family
FHG54_RS13025	COG0006	proline dipeptidase activity
FHG54_RS13040	COG2239	Acts as a magnesium transporter
FHG54_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS13085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FHG54_RS13105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHG54_RS13110	COG3548	integral membrane protein
FHG54_RS13115	COG2171	N-acyltransferase activity
FHG54_RS13150	COG1024	Enoyl-CoA hydratase
FHG54_RS13155	COG0739	heme binding
FHG54_RS13160	COG1217	gtp-binding protein TYPA
FHG54_RS13175	COG0601	transmembrane transport
FHG54_RS13200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FHG54_RS13200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FHG54_RS13205	COG0509	glycine decarboxylation via glycine cleavage system
FHG54_RS13210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FHG54_RS13215	COG2132	Multicopper oxidase
FHG54_RS13230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FHG54_RS13235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FHG54_RS13245	COG1104	cysteine desulfurase activity
FHG54_RS13250	COG2814	Major facilitator Superfamily
FHG54_RS13265	COG2890	protein-(glutamine-N5) methyltransferase activity
FHG54_RS13280	COG0488	(ABC) transporter
FHG54_RS13285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHG54_RS13290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHG54_RS13310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHG54_RS13315	COG3237	CsbD-like
FHG54_RS13320	COG2066	Belongs to the glutaminase family
FHG54_RS13380	COG2176	DNA-directed DNA polymerase activity
FHG54_RS13385	COG1322	Protein conserved in bacteria
FHG54_RS13405	COG1494	fructose-1,6-bisphosphatase
FHG54_RS13410	COG0191	fructose-bisphosphate aldolase activity
FHG54_RS13420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FHG54_RS13425	COG1570	exodeoxyribonuclease VII activity
FHG54_RS13430	COG1722	exodeoxyribonuclease VII activity
FHG54_RS13445	COG0114	fumarate hydratase activity
FHG54_RS13450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FHG54_RS13460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FHG54_RS13480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHG54_RS13485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FHG54_RS13495	COG3214	Protein conserved in bacteria
FHG54_RS13500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHG54_RS13510	COG1704	LemA family
FHG54_RS13515	COG1131	(ABC) transporter
FHG54_RS13535	COG2814	Major facilitator Superfamily
FHG54_RS13545	COG0248	Ppx GppA phosphatase
FHG54_RS13565	COG1404	Belongs to the peptidase S8 family
FHG54_RS13580	COG0148	phosphopyruvate hydratase activity
FHG54_RS13585	COG0124	histidyl-tRNA synthetase
FHG54_RS13595	COG3956	TIGRFAM MazG family protein
FHG54_RS13600	COG1280	lysine exporter protein (LysE YggA)
FHG54_RS13605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FHG54_RS13620	COG0328	RNA-DNA hybrid ribonuclease activity
FHG54_RS13625	COG0193	aminoacyl-tRNA hydrolase activity
FHG54_RS13630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FHG54_RS13635	COG3265	gluconokinase activity
FHG54_RS13640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FHG54_RS13645	COG2149	membrane
FHG54_RS13665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FHG54_RS13670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FHG54_RS13680	COG1846	Transcriptional regulator
FHG54_RS13690	COG2011	ABC-type metal ion transport system permease component
FHG54_RS13695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHG54_RS13705	COG0488	(ABC) transporter
FHG54_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
FHG54_RS13715	COG1309	transcriptional regulator
FHG54_RS13720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FHG54_RS13730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FHG54_RS13735	COG0084	hydrolase, TatD family'
FHG54_RS13740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHG54_RS13755	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
FHG54_RS13760	COG0596	Alpha beta hydrolase
FHG54_RS13770	COG0318	PFAM AMP-dependent synthetase and ligase
FHG54_RS13780	COG0604	alcohol dehydrogenase
FHG54_RS13785	COG1476	TRANSCRIPTIONal
FHG54_RS13795	COG2076	Multidrug Resistance protein
FHG54_RS13805	COG2873	o-acetylhomoserine
FHG54_RS13810	COG1832	CoA-binding protein
FHG54_RS13820	COG1131	(ABC) transporter
FHG54_RS13860	COG1760	l-serine dehydratase
FHG54_RS13870	COG1846	Transcriptional regulator
FHG54_RS13880	COG1362	aminopeptidase activity
FHG54_RS13885	COG0484	heat shock protein binding
FHG54_RS13910	COG1331	Highly conserved protein containing a thioredoxin domain
FHG54_RS13935	COG1643	Atp-dependent helicase
FHG54_RS13960	COG0656	L-ascorbic acid biosynthetic process
FHG54_RS13975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FHG54_RS13990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS14025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHG54_RS14070	COG1793	dna ligase
FHG54_RS14075	COG3548	integral membrane protein
FHG54_RS14080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHG54_RS14095	COG3942	CHAP domain
FHG54_RS14115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FHG54_RS14130	COG1278	Cold shock
FHG54_RS14145	COG1061	Type III restriction enzyme res subunit
FHG54_RS14155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FHG54_RS14160	COG0745	RESPONSE REGULATOR receiver
FHG54_RS14165	COG2205	protein histidine kinase activity
FHG54_RS14180	COG1929	Belongs to the glycerate kinase type-1 family
FHG54_RS14185	COG4552	Acetyltransferase involved in intracellular survival and related
FHG54_RS14215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHG54_RS14225	COG1846	Transcriptional regulator
FHG54_RS14240	COG0740	serine-type endopeptidase activity
FHG54_RS14245	COG0740	serine-type endopeptidase activity
FHG54_RS14305	COG0596	Alpha beta hydrolase
FHG54_RS14390	COG1396	sequence-specific DNA binding
FHG54_RS14405	COG1793	dna ligase
FHG54_RS14435	COG1309	transcriptional regulator
FHG54_RS14480	COG0542	response to heat
FHG54_RS14525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FHG54_RS14530	COG1695	Transcriptional regulator
FHG54_RS14535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FHG54_RS14550	COG0640	Transcriptional regulator
FHG54_RS14615	COG4941	Belongs to the sigma-70 factor family
FHG54_RS14625	COG0488	(ABC) transporter
FHG54_RS14635	COG0477	Major facilitator Superfamily
FHG54_RS14645	COG2409	Drug exporters of the RND superfamily
FHG54_RS14650	COG4585	Histidine kinase
FHG54_RS14655	COG2197	response regulator
FHG54_RS14675	COG0406	alpha-ribazole phosphatase activity
FHG54_RS14690	COG2197	response regulator
FHG54_RS14695	COG4585	Histidine kinase
FHG54_RS14710	COG1253	flavin adenine dinucleotide binding
FHG54_RS14745	COG0596	Alpha beta hydrolase
FHG54_RS14745	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHG54_RS14755	COG2197	response regulator
FHG54_RS14760	COG4585	Histidine kinase
FHG54_RS14770	COG1131	(ABC) transporter
FHG54_RS14820	COG5002	protein histidine kinase activity
FHG54_RS14835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FHG54_RS14835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FHG54_RS14865	COG2409	Drug exporters of the RND superfamily
FHG54_RS14880	COG3119	arylsulfatase activity
FHG54_RS14935	COG0822	iron-sulfur transferase activity
FHG54_RS14955	COG2409	Drug exporters of the RND superfamily
FHG54_RS14965	COG1595	DNA-templated transcription, initiation
FHG54_RS14975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FHG54_RS15000	COG3848	Pyruvate phosphate dikinase
FHG54_RS15000	COG0574	Belongs to the PEP-utilizing enzyme family
FHG54_RS15020	COG1309	transcriptional regulator
FHG54_RS15030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FHG54_RS15035	COG2086	electron transfer activity
FHG54_RS15040	COG1960	acyl-CoA dehydrogenase activity
FHG54_RS15055	COG2850	peptidyl-arginine hydroxylation
FHG54_RS15070	COG1846	Transcriptional regulator
FHG54_RS15080	COG0583	DNA-binding transcription factor activity
FHG54_RS15120	COG4608	Belongs to the ABC transporter superfamily
FHG54_RS15125	COG0444	Belongs to the ABC transporter superfamily
FHG54_RS15130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHG54_RS15135	COG0601	transmembrane transport
FHG54_RS15145	COG0583	DNA-binding transcription factor activity
FHG54_RS15155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FHG54_RS15190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHG54_RS15200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHG54_RS15205	COG1780	Probably involved in ribonucleotide reductase function
FHG54_RS15215	COG1470	cell adhesion involved in biofilm formation
FHG54_RS15215	COG0366	Alpha amylase catalytic
FHG54_RS15240	COG0395	ABC-type sugar transport system, permease component
FHG54_RS15285	COG2160	L-arabinose isomerase activity
FHG54_RS15320	COG1609	Transcriptional regulator
FHG54_RS15355	COG3940	Belongs to the glycosyl hydrolase 43 family
FHG54_RS15365	COG4214	carbohydrate transport
FHG54_RS15370	COG1129	ABC transporter
FHG54_RS15375	COG4213	ABC transporter substrate-binding protein
FHG54_RS15385	COG1609	Transcriptional regulator
FHG54_RS15425	COG2197	response regulator
FHG54_RS15450	COG1132	(ABC) transporter
FHG54_RS15455	COG0395	ABC-type sugar transport system, permease component
FHG54_RS15460	COG1175	transmembrane transport
FHG54_RS15465	COG1653	transport
FHG54_RS15485	COG0395	ABC-type sugar transport system, permease component
FHG54_RS15490	COG1175	transmembrane transport
FHG54_RS15520	COG0222	ribosome binding
FHG54_RS15525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FHG54_RS15550	COG2205	protein histidine kinase activity
FHG54_RS15555	COG0745	RESPONSE REGULATOR receiver
FHG54_RS15585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHG54_RS15605	COG1172	Belongs to the binding-protein-dependent transport system permease family
FHG54_RS15610	COG1172	Belongs to the binding-protein-dependent transport system permease family
FHG54_RS15615	COG1129	ABC transporter
FHG54_RS15620	COG0673	inositol 2-dehydrogenase activity
FHG54_RS15645	COG3321	synthase
FHG54_RS15645	COG0604	alcohol dehydrogenase
FHG54_RS15670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FHG54_RS15690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FHG54_RS15730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FHG54_RS15735	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FHG54_RS15745	COG0006	proline dipeptidase activity
FHG54_RS15750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHG54_RS15755	COG0477	Major facilitator Superfamily
FHG54_RS15760	COG1126	abc transporter atp-binding protein
FHG54_RS15765	COG0765	amino acid transport
FHG54_RS15770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHG54_RS15785	COG1012	belongs to the aldehyde dehydrogenase family
FHG54_RS15805	COG2197	response regulator
FHG54_RS15815	COG1254	Belongs to the acylphosphatase family
FHG54_RS15820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHG54_RS15825	COG0081	regulation of translation
FHG54_RS15830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FHG54_RS15850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FHG54_RS15865	COG0436	Aminotransferase
FHG54_RS15870	COG0583	DNA-binding transcription factor activity
FHG54_RS15885	COG1131	(ABC) transporter
FHG54_RS15900	COG2197	response regulator
FHG54_RS15935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FHG54_RS15945	COG2030	dehydratase
FHG54_RS15960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHG54_RS15975	COG2723	6-phospho-beta-galactosidase activity
FHG54_RS16005	COG0385	Bile acid
FHG54_RS16030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHG54_RS16055	COG4585	Histidine kinase
FHG54_RS16060	COG2197	response regulator
FHG54_RS16065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHG54_RS16070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FHG54_RS16075	COG0438	transferase activity, transferring glycosyl groups
FHG54_RS16110	COG0444	Belongs to the ABC transporter superfamily
FHG54_RS16150	COG4948	Mandelate Racemase Muconate Lactonizing
FHG54_RS16155	COG2362	D-Aminopeptidase
FHG54_RS16160	COG1309	transcriptional regulator
FHG54_RS16170	COG1404	Belongs to the peptidase S8 family