locus-tag	class	description
EYB66_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS00020	COG1322	Protein conserved in bacteria
EYB66_RS00025	COG0546	phosphoglycolate phosphatase activity
EYB66_RS00030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYB66_RS00040	COG4591	ABC-type transport system involved in lipoprotein release permease component
EYB66_RS00065	COG2234	aminopeptidase activity
EYB66_RS00070	COG2755	lipolytic protein G-D-S-L family
EYB66_RS00070	COG0657	acetylesterase activity
EYB66_RS00075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EYB66_RS00095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EYB66_RS00100	COG2267	carboxylic ester hydrolase activity
EYB66_RS00110	COG0335	large ribosomal subunit rRNA binding
EYB66_RS00120	COG0346	lactoylglutathione lyase activity
EYB66_RS00135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EYB66_RS00140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EYB66_RS00150	COG0427	acetyl-CoA hydrolase
EYB66_RS00160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EYB66_RS00170	COG0205	6-phosphofructokinase activity
EYB66_RS00180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EYB66_RS00185	COG0028	Belongs to the TPP enzyme family
EYB66_RS00205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EYB66_RS00220	COG0471	metal ion transport
EYB66_RS00230	COG0351	phosphomethylpyrimidine kinase
EYB66_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
EYB66_RS00290	COG0242	peptide deformylase activity
EYB66_RS00295	COG1063	alcohol dehydrogenase
EYB66_RS00305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EYB66_RS00310	COG1393	Belongs to the ArsC family
EYB66_RS00315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EYB66_RS00320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EYB66_RS00330	COG1187	pseudouridine synthase activity
EYB66_RS00340	COG0336	Belongs to the RNA methyltransferase TrmD family
EYB66_RS00345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EYB66_RS00355	COG0539	negative regulation of cytoplasmic translation
EYB66_RS00400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EYB66_RS00405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EYB66_RS00410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EYB66_RS00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYB66_RS00455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYB66_RS00475	COG0662	Cupin 2, conserved barrel domain protein
EYB66_RS00475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EYB66_RS00485	COG0416	fatty acid biosynthetic process
EYB66_RS00490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EYB66_RS00500	COG0537	adenosine 5'-monophosphoramidase activity
EYB66_RS00505	COG0009	L-threonylcarbamoyladenylate synthase
EYB66_RS00510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EYB66_RS00515	COG0228	four-way junction DNA binding
EYB66_RS00535	COG1862	Preprotein translocase
EYB66_RS00540	COG0343	queuine tRNA-ribosyltransferase activity
EYB66_RS00545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EYB66_RS00555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EYB66_RS00560	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EYB66_RS00565	COG0776	regulation of translation
EYB66_RS00595	COG0811	peptide transport
EYB66_RS00610	COG3250	beta-galactosidase activity
EYB66_RS00615	COG0525	valine-tRNA ligase activity
EYB66_RS00625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EYB66_RS00630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EYB66_RS00635	COG0255	Belongs to the universal ribosomal protein uL29 family
EYB66_RS00640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EYB66_RS00645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EYB66_RS00650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EYB66_RS00660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EYB66_RS00665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EYB66_RS00670	COG0089	rRNA binding
EYB66_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EYB66_RS00680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EYB66_RS00685	COG0051	transcription antitermination factor activity, RNA binding
EYB66_RS00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EYB66_RS00695	COG0049	tRNA binding
EYB66_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EYB66_RS00705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EYB66_RS00715	COG3852	Histidine kinase
EYB66_RS00720	COG2204	response regulator
EYB66_RS00730	COG1722	exodeoxyribonuclease VII activity
EYB66_RS00735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EYB66_RS00750	COG0795	lipopolysaccharide-transporting ATPase activity
EYB66_RS00755	COG1160	GTP binding
EYB66_RS00760	COG0444	Belongs to the ABC transporter superfamily
EYB66_RS00780	COG1136	(ABC) transporter
EYB66_RS00780	COG0577	efflux transmembrane transporter activity
EYB66_RS00790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EYB66_RS00835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EYB66_RS00840	COG0799	negative regulation of ribosome biogenesis
EYB66_RS00845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EYB66_RS00895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EYB66_RS00910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EYB66_RS00920	COG0300	oxidoreductase activity
EYB66_RS00940	COG0038	chloride channel
EYB66_RS00950	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS00965	COG0076	glutamate decarboxylase activity
EYB66_RS00980	COG0167	dihydroorotate dehydrogenase activity
EYB66_RS00985	COG0352	thiamine-phosphate diphosphorylase activity
EYB66_RS01005	COG1253	flavin adenine dinucleotide binding
EYB66_RS01010	COG1253	flavin adenine dinucleotide binding
EYB66_RS01015	COG1185	polyribonucleotide nucleotidyltransferase activity
EYB66_RS01020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EYB66_RS01025	COG0110	maltose O-acetyltransferase activity
EYB66_RS01050	COG0101	tRNA pseudouridine synthase activity
EYB66_RS01055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EYB66_RS01070	COG4968	Prepilin-type N-terminal cleavage methylation domain
EYB66_RS01085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS01090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EYB66_RS01105	COG1136	(ABC) transporter
EYB66_RS01110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EYB66_RS01120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYB66_RS01145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS01150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EYB66_RS01155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EYB66_RS01165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EYB66_RS01170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EYB66_RS01180	COG2814	Major facilitator Superfamily
EYB66_RS01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYB66_RS01195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EYB66_RS01195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EYB66_RS01200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EYB66_RS01205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EYB66_RS01210	COG0552	protein localization to endoplasmic reticulum
EYB66_RS01215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EYB66_RS01235	COG1058	Belongs to the CinA family
EYB66_RS01235	COG1546	Belongs to the CinA family
EYB66_RS01245	COG0456	acetyltransferase
EYB66_RS01270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EYB66_RS01275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EYB66_RS01280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EYB66_RS01285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EYB66_RS01300	COG0758	DNA mediated transformation
EYB66_RS01305	COG1686	Belongs to the peptidase S11 family
EYB66_RS01310	COG0012	GTP binding
EYB66_RS01315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EYB66_RS01325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EYB66_RS01325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EYB66_RS01340	COG3119	arylsulfatase activity
EYB66_RS01365	COG2259	Doxx family
EYB66_RS01370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EYB66_RS01400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EYB66_RS01420	COG2326	polyphosphate kinase activity
EYB66_RS01425	COG1349	DNA-binding transcription factor activity
EYB66_RS01440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EYB66_RS01445	COG1162	GTPase activity
EYB66_RS01460	COG0742	ribosomal rna small subunit methyltransferase
EYB66_RS01475	COG2326	polyphosphate kinase activity
EYB66_RS01485	COG5434	Belongs to the glycosyl hydrolase 28 family
EYB66_RS01495	COG1073	alpha beta
EYB66_RS01500	COG0802	atpase or kinase
EYB66_RS01505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EYB66_RS01510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EYB66_RS01515	COG0735	belongs to the Fur family
EYB66_RS01520	COG0396	ATPase activity
EYB66_RS01525	COG0719	Fe-S assembly protein
EYB66_RS01530	COG0719	Fe-S assembly protein
EYB66_RS01545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EYB66_RS01590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EYB66_RS01610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EYB66_RS01615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EYB66_RS01620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EYB66_RS01625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EYB66_RS01630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EYB66_RS01635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EYB66_RS01645	COG0356	it plays a direct role in the translocation of protons across the membrane
EYB66_RS01695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EYB66_RS01725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EYB66_RS01730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EYB66_RS01735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EYB66_RS01745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EYB66_RS01755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EYB66_RS01760	COG0047	phosphoribosylformylglycinamidine synthase activity
EYB66_RS01770	COG1363	Peptidase, m42
EYB66_RS01785	COG1077	Cell shape determining protein MreB Mrl
EYB66_RS01790	COG1530	ribonuclease E activity
EYB66_RS01815	COG0848	biopolymer transport protein
EYB66_RS01830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EYB66_RS01845	COG0134	indole-3-glycerol-phosphate synthase activity
EYB66_RS01850	COG0792	nuclease activity
EYB66_RS01860	COG1253	flavin adenine dinucleotide binding
EYB66_RS01870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EYB66_RS01875	COG0137	argininosuccinate synthase activity
EYB66_RS01880	COG3119	arylsulfatase activity
EYB66_RS01890	COG0149	triose-phosphate isomerase activity
EYB66_RS01925	COG1040	competence protein
EYB66_RS01935	COG3956	TIGRFAM MazG family protein
EYB66_RS01955	COG1663	tetraacyldisaccharide 4'-kinase activity
EYB66_RS01960	COG0612	Peptidase, M16
EYB66_RS01985	COG0673	inositol 2-dehydrogenase activity
EYB66_RS02010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EYB66_RS02015	COG0424	maF-like protein
EYB66_RS02020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EYB66_RS02050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EYB66_RS02060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EYB66_RS02070	COG0571	ribonuclease III activity
EYB66_RS02090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EYB66_RS02105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EYB66_RS02125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EYB66_RS02140	COG2226	methyltransferase
EYB66_RS02150	COG2076	Multidrug Resistance protein
EYB66_RS02235	COG2255	four-way junction helicase activity
EYB66_RS02240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EYB66_RS02245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EYB66_RS02250	COG1215	transferase activity, transferring glycosyl groups
EYB66_RS02255	COG0463	Glycosyl transferase, family 2
EYB66_RS02255	COG1216	Glycosyl transferase, family 2
EYB66_RS02280	COG0438	transferase activity, transferring glycosyl groups
EYB66_RS02290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EYB66_RS02300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EYB66_RS02305	COG0482	sulfurtransferase activity
EYB66_RS02310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EYB66_RS02320	COG2860	membrane
EYB66_RS02325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EYB66_RS02330	COG2001	Belongs to the MraZ family
EYB66_RS02335	COG0275	rRNA processing
EYB66_RS02345	COG0768	penicillin binding
EYB66_RS02350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EYB66_RS02355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EYB66_RS02360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EYB66_RS02365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EYB66_RS02375	COG0772	Belongs to the SEDS family
EYB66_RS02380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EYB66_RS02385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EYB66_RS02390	COG1181	Belongs to the D-alanine--D-alanine ligase family
EYB66_RS02400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EYB66_RS02405	COG0860	N-Acetylmuramoyl-L-alanine amidase
EYB66_RS02410	COG0321	lipoyl(octanoyl) transferase activity
EYB66_RS02415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EYB66_RS02420	COG0066	3-isopropylmalate dehydratase activity
EYB66_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS02440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EYB66_RS02445	COG4608	Belongs to the ABC transporter superfamily
EYB66_RS02455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EYB66_RS02460	COG0052	Belongs to the universal ribosomal protein uS2 family
EYB66_RS02470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EYB66_RS02485	COG1137	ATPase activity
EYB66_RS02495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EYB66_RS02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EYB66_RS02535	COG0017	Asparaginyl-tRNA synthetase
EYB66_RS02545	COG3118	belongs to the thioredoxin family
EYB66_RS02595	COG0583	DNA-binding transcription factor activity
EYB66_RS02600	COG2855	membrane
EYB66_RS02605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EYB66_RS02615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EYB66_RS02625	COG0602	queuosine metabolic process
EYB66_RS02630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EYB66_RS02635	COG0217	transcriptional regulatory protein
EYB66_RS02640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EYB66_RS02645	COG4651	solute:proton antiporter activity
EYB66_RS02645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EYB66_RS02655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EYB66_RS02660	COG4864	UPF0365 protein
EYB66_RS02670	COG2022	thiamine diphosphate biosynthetic process
EYB66_RS02675	COG0531	amino acid
EYB66_RS02685	COG0628	permease
EYB66_RS02690	COG0019	diaminopimelate decarboxylase activity
EYB66_RS02695	COG0191	fructose-bisphosphate aldolase activity
EYB66_RS02700	COG1217	gtp-binding protein TYPA
EYB66_RS02730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EYB66_RS02795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYB66_RS02800	COG0517	IMP dehydrogenase activity
EYB66_RS02800	COG0516	GMP reductase activity
EYB66_RS02805	COG0519	Catalyzes the synthesis of GMP from XMP
EYB66_RS02805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EYB66_RS02815	COG0546	phosphoglycolate phosphatase activity
EYB66_RS02835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EYB66_RS02850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EYB66_RS02855	COG0196	riboflavin kinase activity
EYB66_RS02860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EYB66_RS02870	COG1408	metallophosphoesterase
EYB66_RS02880	COG1216	Glycosyl transferase, family 2
EYB66_RS02880	COG1442	glycosyl transferase family 8
EYB66_RS02890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYB66_RS02895	COG1216	Glycosyl transferase, family 2
EYB66_RS02915	COG2755	lipolytic protein G-D-S-L family
EYB66_RS02915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EYB66_RS02930	COG0471	metal ion transport
EYB66_RS02930	COG0490	domain, Protein
EYB66_RS02965	COG0588	phosphoglycerate mutase activity
EYB66_RS02970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EYB66_RS02980	COG0477	Major facilitator Superfamily
EYB66_RS02985	COG1607	acyl-coa hydrolase
EYB66_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
EYB66_RS03005	COG1525	nuclease
EYB66_RS03020	COG1475	DNA binding
EYB66_RS03025	COG3969	phosphoadenosine phosphosulfate
EYB66_RS03040	COG0473	3-isopropylmalate dehydrogenase activity
EYB66_RS03065	COG2873	o-acetylhomoserine
EYB66_RS03070	COG0535	radical SAM domain protein
EYB66_RS03075	COG0535	radical SAM domain protein
EYB66_RS03090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EYB66_RS03095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EYB66_RS03105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EYB66_RS03115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EYB66_RS03115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EYB66_RS03115	COG0674	pyruvate-flavodoxin oxidoreductase activity
EYB66_RS03115	COG1013	pyruvate-flavodoxin oxidoreductase activity
EYB66_RS03125	COG1733	regulation of RNA biosynthetic process
EYB66_RS03135	COG0107	imidazoleglycerol-phosphate synthase activity
EYB66_RS03140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EYB66_RS03150	COG1643	Atp-dependent helicase
EYB66_RS03155	COG0440	acetolactate synthase activity
EYB66_RS03160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS03170	COG0445	tRNA wobble uridine modification
EYB66_RS03175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYB66_RS03175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYB66_RS03180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EYB66_RS03190	COG0592	DNA-directed DNA polymerase activity
EYB66_RS03215	COG0791	NLP P60 protein
EYB66_RS03215	COG1388	LysM domain
EYB66_RS03220	COG0084	hydrolase, TatD family'
EYB66_RS03230	COG3250	beta-galactosidase activity
EYB66_RS03245	COG2205	protein histidine kinase activity
EYB66_RS03250	COG0745	RESPONSE REGULATOR receiver
EYB66_RS03260	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EYB66_RS03270	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EYB66_RS03285	COG0542	response to heat
EYB66_RS03330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EYB66_RS03340	COG0659	secondary active sulfate transmembrane transporter activity
EYB66_RS03345	COG0165	Argininosuccinate lyase
EYB66_RS03360	COG0148	phosphopyruvate hydratase activity
EYB66_RS03365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EYB66_RS03375	COG3481	metal-dependent phosphohydrolase, HD sub domain
EYB66_RS03385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EYB66_RS03390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EYB66_RS03420	COG0490	domain, Protein
EYB66_RS03420	COG2985	domain, Protein
EYB66_RS03435	COG0471	metal ion transport
EYB66_RS03460	COG2194	sulfuric ester hydrolase activity
EYB66_RS03465	COG1592	Rubrerythrin
EYB66_RS03475	COG1363	Peptidase, m42
EYB66_RS03480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS03490	COG1785	Belongs to the alkaline phosphatase family
EYB66_RS03495	COG1970	mechanosensitive ion channel activity
EYB66_RS03500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EYB66_RS03510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EYB66_RS03520	COG2217	Heavy metal translocating P-type atpase
EYB66_RS03525	COG0497	DNA recombination
EYB66_RS03530	COG0321	lipoyl(octanoyl) transferase activity
EYB66_RS03530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EYB66_RS03535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EYB66_RS03560	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYB66_RS03565	COG0022	dehydrogenase e1 component
EYB66_RS03570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EYB66_RS03575	COG0789	Transcriptional regulator
EYB66_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYB66_RS03585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYB66_RS03645	COG3409	Peptidoglycan-binding domain 1 protein
EYB66_RS03645	COG5632	N-Acetylmuramoyl-L-alanine amidase
EYB66_RS03650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EYB66_RS03675	COG1690	Belongs to the RtcB family
EYB66_RS03685	COG2814	Major facilitator Superfamily
EYB66_RS03695	COG2096	Adenosyltransferase
EYB66_RS03705	COG0557	exoribonuclease II activity
EYB66_RS03710	COG0826	peptidase U32
EYB66_RS03715	COG0285	dihydrofolate synthase activity
EYB66_RS03730	COG0673	inositol 2-dehydrogenase activity
EYB66_RS03735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EYB66_RS03740	COG0737	Belongs to the 5'-nucleotidase family
EYB66_RS03750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EYB66_RS03755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EYB66_RS03770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EYB66_RS03775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EYB66_RS03780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EYB66_RS03785	COG0200	Binds to the 23S rRNA
EYB66_RS03790	COG0201	protein transport
EYB66_RS03795	COG0563	adenylate kinase activity
EYB66_RS03800	COG0024	Methionine aminopeptidase
EYB66_RS03815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EYB66_RS03820	COG1442	glycosyl transferase family 8
EYB66_RS03830	COG1216	Glycosyl transferase, family 2
EYB66_RS03840	COG1216	Glycosyl transferase, family 2
EYB66_RS03850	COG1216	Glycosyl transferase, family 2
EYB66_RS03855	COG0693	protein deglycase activity
EYB66_RS03860	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYB66_RS03865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EYB66_RS03870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EYB66_RS03880	COG1966	Carbon starvation protein
EYB66_RS03895	COG3119	arylsulfatase activity
EYB66_RS03900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EYB66_RS03905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EYB66_RS03910	COG0195	Participates in both transcription termination and antitermination
EYB66_RS03915	COG0708	Exodeoxyribonuclease III
EYB66_RS03920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EYB66_RS03925	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EYB66_RS03930	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
EYB66_RS03940	COG0842	Transport permease protein
EYB66_RS03940	COG1131	(ABC) transporter
EYB66_RS03940	COG1716	ATPase activity
EYB66_RS03960	COG0724	RNA recognition motif
EYB66_RS03965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EYB66_RS03985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EYB66_RS03995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EYB66_RS04000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EYB66_RS04015	COG1490	D-aminoacyl-tRNA deacylase activity
EYB66_RS04030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EYB66_RS04035	COG1053	succinate dehydrogenase
EYB66_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
EYB66_RS04090	COG0488	(ABC) transporter
EYB66_RS04100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EYB66_RS04110	COG1253	flavin adenine dinucleotide binding
EYB66_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
EYB66_RS04125	COG1073	alpha beta
EYB66_RS04135	COG0667	Aldo Keto reductase
EYB66_RS04195	COG2267	carboxylic ester hydrolase activity
EYB66_RS04200	COG2095	MarC family integral membrane protein
EYB66_RS04240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EYB66_RS04245	COG0488	(ABC) transporter
EYB66_RS04255	COG0697	spore germination
EYB66_RS04265	COG0215	cysteine-tRNA ligase activity
EYB66_RS04275	COG3119	arylsulfatase activity
EYB66_RS04285	COG0481	GTPase activity
EYB66_RS04300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EYB66_RS04305	COG0085	RNA polymerase activity
EYB66_RS04310	COG0222	ribosome binding
EYB66_RS04315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EYB66_RS04320	COG0081	regulation of translation
EYB66_RS04325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EYB66_RS04330	COG0250	Participates in transcription elongation, termination and antitermination
EYB66_RS04345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EYB66_RS04365	COG0740	serine-type endopeptidase activity
EYB66_RS04370	COG0544	peptidyl-prolyl cis-trans isomerase activity
EYB66_RS04385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EYB66_RS04405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYB66_RS04445	COG2226	methyltransferase
EYB66_RS04450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EYB66_RS04455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EYB66_RS04470	COG1902	pentaerythritol trinitrate reductase activity
EYB66_RS04470	COG0446	pyridine nucleotide-disulphide oxidoreductase
EYB66_RS04480	COG3119	arylsulfatase activity
EYB66_RS04485	COG0514	ATP-dependent DNA helicase (RecQ)
EYB66_RS04505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EYB66_RS04510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EYB66_RS04565	COG1858	cytochrome C peroxidase
EYB66_RS04570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EYB66_RS04575	COG0590	tRNA wobble adenosine to inosine editing
EYB66_RS04580	COG1940	carbohydrate kinase activity
EYB66_RS04585	COG2217	Heavy metal translocating P-type atpase
EYB66_RS04590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EYB66_RS04595	COG0237	dephospho-CoA kinase activity
EYB66_RS04625	COG1363	Peptidase, m42
EYB66_RS04630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EYB66_RS04640	COG0006	proline dipeptidase activity
EYB66_RS04645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EYB66_RS04655	COG5002	protein histidine kinase activity
EYB66_RS04660	COG0745	RESPONSE REGULATOR receiver
EYB66_RS04665	COG0129	dihydroxy-acid dehydratase activity
EYB66_RS04690	COG1368	sulfuric ester hydrolase activity
EYB66_RS04725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EYB66_RS04730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EYB66_RS04755	COG0534	Mate efflux family protein
EYB66_RS04760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EYB66_RS04775	COG1876	peptidase activity
EYB66_RS04820	COG3209	COG3209 Rhs family protein
EYB66_RS04860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EYB66_RS04865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EYB66_RS04870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EYB66_RS04875	COG2205	protein histidine kinase activity
EYB66_RS04880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYB66_RS04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYB66_RS04905	COG0667	Aldo Keto reductase
EYB66_RS04910	COG0789	Transcriptional regulator
EYB66_RS04955	COG0714	Associated with various cellular activities
EYB66_RS04980	COG1090	epimerase
EYB66_RS04990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EYB66_RS04995	COG1119	ATPase activity
EYB66_RS05000	COG2186	Transcriptional regulator
EYB66_RS05020	COG0148	phosphopyruvate hydratase activity
EYB66_RS05025	COG0436	Aminotransferase
EYB66_RS05030	COG1477	protein flavinylation
EYB66_RS05045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EYB66_RS05055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EYB66_RS05075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EYB66_RS05085	COG1199	ATP-dependent helicase activity
EYB66_RS05090	COG1122	ATPase activity
EYB66_RS05115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EYB66_RS05120	COG0598	Magnesium transport protein CorA
EYB66_RS05125	COG0359	binds to the 23S rRNA
EYB66_RS05130	COG0138	bifunctional purine biosynthesis protein purh
EYB66_RS05135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EYB66_RS05140	COG0736	holo-[acyl-carrier-protein] synthase activity
EYB66_RS05150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EYB66_RS05155	COG5632	N-Acetylmuramoyl-L-alanine amidase
EYB66_RS05155	COG3409	Peptidoglycan-binding domain 1 protein
EYB66_RS05160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EYB66_RS05170	COG0437	4 iron, 4 sulfur cluster binding
EYB66_RS05190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EYB66_RS05245	COG0284	orotidine-5'-phosphate decarboxylase activity
EYB66_RS05265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EYB66_RS05270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EYB66_RS05290	COG2003	Belongs to the UPF0758 family
EYB66_RS05295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EYB66_RS05295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EYB66_RS05300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EYB66_RS05305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EYB66_RS05310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EYB66_RS05315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EYB66_RS05320	COG0322	excinuclease ABC activity
EYB66_RS05325	COG0811	peptide transport
EYB66_RS05330	COG0848	biopolymer transport protein
EYB66_RS05340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EYB66_RS05345	COG0483	inositol monophosphate 1-phosphatase activity
EYB66_RS05350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EYB66_RS05360	COG1482	cell wall glycoprotein biosynthetic process
EYB66_RS05370	COG1757	Na H antiporter
EYB66_RS05375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYB66_RS05380	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EYB66_RS05385	COG0505	Belongs to the CarA family
EYB66_RS05390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EYB66_RS05405	COG0067	glutamate synthase
EYB66_RS05405	COG0070	glutamate synthase
EYB66_RS05405	COG0069	glutamate synthase activity
EYB66_RS05415	COG0706	membrane insertase activity
EYB66_RS05420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EYB66_RS05430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EYB66_RS05440	COG2755	lipolytic protein G-D-S-L family
EYB66_RS05440	COG0657	acetylesterase activity
EYB66_RS05450	COG0676	glucose-6-phosphate 1-epimerase activity
EYB66_RS05455	COG0259	pyridoxamine-phosphate oxidase activity
EYB66_RS05470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EYB66_RS05485	COG1760	l-serine dehydratase
EYB66_RS05490	COG0492	ferredoxin-NADP+ reductase activity
EYB66_RS05490	COG3118	belongs to the thioredoxin family
EYB66_RS05540	COG1408	metallophosphoesterase
EYB66_RS05550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EYB66_RS05555	COG0545	Peptidyl-prolyl cis-trans isomerase
EYB66_RS05570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EYB66_RS05580	COG0826	peptidase U32
EYB66_RS05590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYB66_RS05620	COG0581	inorganic phosphate transmembrane transporter activity
EYB66_RS05625	COG0573	inorganic phosphate transmembrane transporter activity
EYB66_RS05635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EYB66_RS05645	COG2017	converts alpha-aldose to the beta-anomer
EYB66_RS05660	COG0612	Peptidase, M16
EYB66_RS05690	COG0233	cytoplasmic translational termination
EYB66_RS05695	COG0528	UMP kinase activity
EYB66_RS05700	COG0668	transmembrane transport
EYB66_RS05705	COG0450	alkyl hydroperoxide reductase
EYB66_RS05710	COG0733	neurotransmitter:sodium symporter activity
EYB66_RS05725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EYB66_RS05735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EYB66_RS05740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EYB66_RS05745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EYB66_RS05765	COG0842	Transport permease protein
EYB66_RS05770	COG0842	Transport permease protein
EYB66_RS05775	COG1131	(ABC) transporter
EYB66_RS05785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EYB66_RS05790	COG1183	phosphatidylcholine synthase activity
EYB66_RS05800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EYB66_RS05810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EYB66_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
EYB66_RS05835	COG0156	8-amino-7-oxononanoate synthase activity
EYB66_RS05855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EYB66_RS05860	COG0124	histidyl-tRNA synthetase
EYB66_RS05865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EYB66_RS05870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EYB66_RS05875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EYB66_RS05885	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EYB66_RS05895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EYB66_RS05900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EYB66_RS05935	COG0443	Heat shock 70 kDa protein
EYB66_RS05940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EYB66_RS05945	COG0459	protein refolding
EYB66_RS05995	COG0632	four-way junction helicase activity
EYB66_RS06005	COG0126	phosphoglycerate kinase activity
EYB66_RS06015	COG1082	Xylose isomerase domain protein TIM barrel
EYB66_RS06020	COG4991	sh3 domain protein
EYB66_RS06020	COG0515	serine threonine protein kinase
EYB66_RS06020	COG3064	Membrane
EYB66_RS06025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EYB66_RS06035	COG2271	Major facilitator Superfamily
EYB66_RS06050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EYB66_RS06060	COG0037	tRNA processing
EYB66_RS06065	COG0254	rRNA binding
EYB66_RS06100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EYB66_RS06105	COG0039	L-malate dehydrogenase activity
EYB66_RS06125	COG0778	Nitroreductase
EYB66_RS06130	COG0564	pseudouridine synthase activity
EYB66_RS06150	COG1126	abc transporter atp-binding protein
EYB66_RS06155	COG0765	amino acid transport
EYB66_RS06165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EYB66_RS06170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EYB66_RS06190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EYB66_RS06215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EYB66_RS06220	COG1872	DUF167
EYB66_RS06225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EYB66_RS06230	COG0484	heat shock protein binding
EYB66_RS06235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EYB66_RS06245	COG5434	Belongs to the glycosyl hydrolase 28 family
EYB66_RS06260	COG0277	FAD linked oxidase domain protein
EYB66_RS06285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EYB66_RS06290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EYB66_RS06300	COG0131	Imidazoleglycerol-phosphate dehydratase
EYB66_RS06305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EYB66_RS06310	COG0360	Binds together with S18 to 16S ribosomal RNA
EYB66_RS06315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EYB66_RS06330	COG1686	Belongs to the peptidase S11 family
EYB66_RS06335	COG0205	6-phosphofructokinase activity
EYB66_RS06345	COG0428	transporter
EYB66_RS06350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYB66_RS06365	COG3977	Valine--pyruvate aminotransferase
EYB66_RS06370	COG1561	YicC-like family, N-terminal region
EYB66_RS06380	COG0471	metal ion transport
EYB66_RS06380	COG3273	potassium ion transport
EYB66_RS06385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYB66_RS06400	COG1575	Belongs to the MenA family. Type 1 subfamily
EYB66_RS06435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYB66_RS06435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYB66_RS06455	COG0202	RNA polymerase activity
EYB66_RS06460	COG0203	ribosomal protein L17
EYB66_RS06465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EYB66_RS06475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EYB66_RS06490	COG2885	chlorophyll binding
EYB66_RS06545	COG0667	Aldo Keto reductase
EYB66_RS06550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EYB66_RS06565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EYB66_RS06570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EYB66_RS06575	COG0134	indole-3-glycerol-phosphate synthase activity
EYB66_RS06580	COG0135	phosphoribosylanthranilate isomerase activity
EYB66_RS06590	COG0159	tryptophan synthase activity
EYB66_RS06605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EYB66_RS06610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EYB66_RS06620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EYB66_RS06650	COG0561	phosphatase activity
EYB66_RS06655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYB66_RS06660	COG2223	nitrite transmembrane transporter activity
EYB66_RS06775	COG3177	Filamentation induced by cAMP protein fic
EYB66_RS06805	COG0556	nucleotide-excision repair
EYB66_RS06810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EYB66_RS06815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EYB66_RS06820	COG0750	zinc metalloprotease
EYB66_RS06835	COG1074	ATP-dependent DNA helicase activity
EYB66_RS06845	COG0697	spore germination
EYB66_RS06855	COG2373	Large extracellular alpha-helical protein
EYB66_RS06860	COG1979	alcohol dehydrogenase
EYB66_RS06870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EYB66_RS06895	COG0372	Belongs to the citrate synthase family
EYB66_RS06910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EYB66_RS06920	COG1187	pseudouridine synthase activity
EYB66_RS06930	COG0105	UTP biosynthetic process
EYB66_RS06935	COG1215	transferase activity, transferring glycosyl groups
EYB66_RS06940	COG0463	Glycosyl transferase, family 2
EYB66_RS06950	COG1459	type II secretion system
EYB66_RS06955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EYB66_RS06960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EYB66_RS06965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYB66_RS06980	COG0728	peptidoglycan biosynthetic process
EYB66_RS06985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EYB66_RS06985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EYB66_RS06995	COG1649	PFAM Uncharacterised BCR, COG1649
EYB66_RS07000	COG1691	(AIR) carboxylase
EYB66_RS07005	COG0037	tRNA processing
EYB66_RS07010	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EYB66_RS07015	COG0142	geranyltranstransferase activity
EYB66_RS07030	COG2151	metal-sulfur cluster biosynthetic enzyme
EYB66_RS07045	COG1007	ATP synthesis coupled electron transport
EYB66_RS07050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYB66_RS07060	COG0713	ATP synthesis coupled electron transport
EYB66_RS07065	COG0839	Belongs to the complex I subunit 6 family
EYB66_RS07075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EYB66_RS07080	COG1034	ATP synthesis coupled electron transport
EYB66_RS07085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EYB66_RS07090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EYB66_RS07095	COG0649	NAD binding
EYB66_RS07105	COG0726	polysaccharide deacetylase
EYB66_RS07115	COG0307	riboflavin synthase, alpha
EYB66_RS07120	COG2264	protein methyltransferase activity
EYB66_RS07125	COG3210	domain, Protein
EYB66_RS07130	COG1640	4-alpha-glucanotransferase
EYB66_RS07140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EYB66_RS07145	COG1030	water channel activity
EYB66_RS07150	COG0358	DNA primase activity
EYB66_RS07155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EYB66_RS07160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EYB66_RS07175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EYB66_RS07180	COG0793	Belongs to the peptidase S41A family
EYB66_RS07195	COG1643	Atp-dependent helicase
EYB66_RS07220	COG1450	Type ii and iii secretion system protein
EYB66_RS07235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EYB66_RS07255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYB66_RS07260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EYB66_RS07270	COG0268	Binds directly to 16S ribosomal RNA
EYB66_RS07275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EYB66_RS07280	COG0028	Belongs to the TPP enzyme family
EYB66_RS07500	COG0688	phosphatidylethanolamine metabolic process
EYB66_RS07505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EYB66_RS07510	COG0495	leucyl-tRNA aminoacylation
EYB66_RS07515	COG3119	arylsulfatase activity
EYB66_RS07530	COG1166	arginine decarboxylase activity
EYB66_RS07540	COG3250	beta-galactosidase activity
EYB66_RS07545	COG3250	beta-galactosidase activity
EYB66_RS07550	COG3250	beta-galactosidase activity
EYB66_RS07555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EYB66_RS07560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS07570	COG0205	6-phosphofructokinase activity
EYB66_RS07590	COG0535	radical SAM domain protein
EYB66_RS07645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EYB66_RS07650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EYB66_RS07655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EYB66_RS07665	COG4771	TonB-dependent receptor
EYB66_RS07685	COG0402	S-adenosylhomocysteine deaminase activity
EYB66_RS07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EYB66_RS07715	COG1294	oxidase, subunit
EYB66_RS07720	COG1271	oxidase subunit
EYB66_RS07730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYB66_RS07750	COG1846	Transcriptional regulator
EYB66_RS07780	COG2949	membrane
EYB66_RS07805	COG0514	ATP-dependent DNA helicase (RecQ)
EYB66_RS07820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EYB66_RS07825	COG0045	succinate-CoA ligase (ADP-forming) activity
EYB66_RS07830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EYB66_RS07890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYB66_RS07895	COG2205	protein histidine kinase activity
EYB66_RS07910	COG0113	porphobilinogen synthase activity
EYB66_RS07920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EYB66_RS07925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EYB66_RS07940	COG0732	type I restriction modification DNA specificity domain
EYB66_RS07955	COG0732	type I restriction modification DNA specificity domain
EYB66_RS07965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EYB66_RS07990	COG4106	trans-aconitate 2-methyltransferase activity
EYB66_RS08005	COG3475	LICD family
EYB66_RS08010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EYB66_RS08020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYB66_RS08025	COG3475	LICD family
EYB66_RS08030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EYB66_RS08040	COG2166	iron-sulfur cluster assembly
EYB66_RS08045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EYB66_RS08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYB66_RS08060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYB66_RS08065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EYB66_RS08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYB66_RS08075	COG1131	(ABC) transporter
EYB66_RS08090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EYB66_RS08105	COG1215	transferase activity, transferring glycosyl groups
EYB66_RS08115	COG2967	ApaG domain
EYB66_RS08125	COG1522	sequence-specific DNA binding
EYB66_RS08130	COG0436	Aminotransferase
EYB66_RS08145	COG0423	glycine-tRNA ligase activity
EYB66_RS08150	COG0656	L-ascorbic acid biosynthetic process
EYB66_RS08165	COG2304	oxidoreductase activity
EYB66_RS08180	COG0714	Associated with various cellular activities
EYB66_RS08185	COG0154	amidase activity
EYB66_RS08190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EYB66_RS08225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS08230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS08240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EYB66_RS08240	COG2755	lipolytic protein G-D-S-L family
EYB66_RS08260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EYB66_RS08270	COG0656	L-ascorbic acid biosynthetic process
EYB66_RS08280	COG0667	Aldo Keto reductase
EYB66_RS08285	COG1408	metallophosphoesterase
EYB66_RS08305	COG0667	Aldo Keto reductase
EYB66_RS08315	COG2249	NAD(P)H dehydrogenase (quinone) activity
EYB66_RS08320	COG0789	Transcriptional regulator
EYB66_RS08335	COG0534	Mate efflux family protein
EYB66_RS08355	COG1091	dTDP-4-dehydrorhamnose reductase activity
EYB66_RS08370	COG1837	Belongs to the UPF0109 family
EYB66_RS08375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EYB66_RS08380	COG0363	glucosamine-6-phosphate deaminase activity
EYB66_RS08400	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EYB66_RS08410	COG1741	Belongs to the pirin family
EYB66_RS08425	COG1070	Carbohydrate kinase
EYB66_RS08440	COG0738	Major facilitator superfamily
EYB66_RS08455	COG1595	DNA-templated transcription, initiation
EYB66_RS08470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EYB66_RS08490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYB66_RS08500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EYB66_RS08505	COG2132	Multicopper oxidase
EYB66_RS08510	COG0697	spore germination
EYB66_RS08520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EYB66_RS08525	COG4608	Belongs to the ABC transporter superfamily
EYB66_RS08530	COG0444	Belongs to the ABC transporter superfamily
EYB66_RS08535	COG4166	transmembrane transport
EYB66_RS08540	COG4239	(ABC) transporter, permease
EYB66_RS08545	COG0601	transmembrane transport
EYB66_RS08565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EYB66_RS08570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EYB66_RS08575	COG3738	Protein conserved in bacteria
EYB66_RS08580	COG0151	Belongs to the GarS family
EYB66_RS08595	COG0811	peptide transport
EYB66_RS08605	COG0242	peptide deformylase activity
EYB66_RS08640	COG2010	Cytochrome c
EYB66_RS08650	COG3258	Cytochrome c
EYB66_RS08665	COG3274	enterobacterial common antigen metabolic process
EYB66_RS08670	COG0538	isocitrate dehydrogenase activity
EYB66_RS08685	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EYB66_RS08690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EYB66_RS08695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EYB66_RS08705	COG0668	transmembrane transport
EYB66_RS08710	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EYB66_RS08710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYB66_RS08715	COG0805	protein transport
EYB66_RS08720	COG1968	undecaprenyl-diphosphatase activity
EYB66_RS08740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EYB66_RS08755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EYB66_RS08765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EYB66_RS08775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EYB66_RS08785	COG1408	metallophosphoesterase
EYB66_RS08810	COG4974	Belongs to the 'phage' integrase family
EYB66_RS08835	COG1454	alcohol dehydrogenase
EYB66_RS08840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EYB66_RS08850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EYB66_RS08850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EYB66_RS08855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EYB66_RS08895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYB66_RS08905	COG4607	ABC-type enterochelin transport system periplasmic component
EYB66_RS08910	COG4604	ABC transporter, ATP-binding protein
EYB66_RS08915	COG4605	iron ion homeostasis
EYB66_RS08920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYB66_RS08955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYB66_RS08955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYB66_RS08970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EYB66_RS08975	COG2195	Cleaves the N-terminal amino acid of tripeptides
EYB66_RS08995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYB66_RS09015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EYB66_RS09040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EYB66_RS09040	COG0519	Catalyzes the synthesis of GMP from XMP
EYB66_RS09045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EYB66_RS09075	COG1410	methionine synthase
EYB66_RS09075	COG0646	methionine synthase
EYB66_RS09080	COG2966	Psort location CytoplasmicMembrane, score
EYB66_RS09085	COG3610	response to peptide
EYB66_RS09095	COG0460	homoserine dehydrogenase
EYB66_RS09100	COG0527	aspartate kinase activity
EYB66_RS09110	COG5522	Integral membrane protein (intg_mem_TP0381)
EYB66_RS09120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EYB66_RS09125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EYB66_RS09130	COG1194	a g-specific adenine glycosylase
EYB66_RS09135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EYB66_RS09140	COG0574	Belongs to the PEP-utilizing enzyme family
EYB66_RS09140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYB66_RS09145	COG0166	Belongs to the GPI family
EYB66_RS09155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EYB66_RS09175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYB66_RS09175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYB66_RS09205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EYB66_RS09210	COG2818	Glycosylase
EYB66_RS09230	COG3033	Beta-eliminating lyase
EYB66_RS09245	COG0072	phenylalanine-tRNA ligase activity
EYB66_RS09245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYB66_RS09265	COG0326	Molecular chaperone. Has ATPase activity
EYB66_RS09295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EYB66_RS09310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EYB66_RS09315	COG1959	2 iron, 2 sulfur cluster binding
EYB66_RS09330	COG0352	thiamine-phosphate diphosphorylase activity
EYB66_RS09335	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EYB66_RS09360	COG1703	isobutyryl-CoA mutase activity
EYB66_RS09380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EYB66_RS09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYB66_RS09395	COG0418	dihydroorotase activity
EYB66_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYB66_RS09430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYB66_RS09445	COG0534	Mate efflux family protein
EYB66_RS09450	COG0489	protein tyrosine kinase activity
EYB66_RS09460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EYB66_RS09465	COG0339	signal peptide processing
EYB66_RS09470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYB66_RS09480	COG1538	Outer membrane efflux protein
EYB66_RS09495	COG4112	unkown
EYB66_RS09510	COG0038	chloride channel
EYB66_RS09520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EYB66_RS09525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYB66_RS09530	COG0586	Pfam SNARE associated Golgi protein
EYB66_RS09600	COG1518	maintenance of DNA repeat elements
EYB66_RS09790	COG0863	Belongs to the N(4) N(6)-methyltransferase family
EYB66_RS09825	COG1012	belongs to the aldehyde dehydrogenase family
EYB66_RS09840	COG0753	catalase activity
EYB66_RS09850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYB66_RS09855	COG1592	Rubrerythrin
EYB66_RS09860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EYB66_RS09880	COG0489	protein tyrosine kinase activity
EYB66_RS09890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EYB66_RS09900	COG0438	transferase activity, transferring glycosyl groups
EYB66_RS09910	COG0438	transferase activity, transferring glycosyl groups
EYB66_RS09950	COG0110	maltose O-acetyltransferase activity
EYB66_RS09960	COG1216	Glycosyl transferase, family 2
EYB66_RS09965	COG1216	Glycosyl transferase, family 2
EYB66_RS09985	COG2755	lipolytic protein G-D-S-L family
EYB66_RS09985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EYB66_RS10005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EYB66_RS10010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYB66_RS10010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYB66_RS10015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EYB66_RS10025	COG0281	malic enzyme
EYB66_RS10025	COG0280	phosphate acetyltransferase
EYB66_RS10040	COG1472	Belongs to the glycosyl hydrolase 3 family
EYB66_RS10045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EYB66_RS10060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EYB66_RS10070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EYB66_RS10075	COG1063	alcohol dehydrogenase
EYB66_RS10090	COG0714	Associated with various cellular activities
EYB66_RS10100	COG0193	aminoacyl-tRNA hydrolase activity
EYB66_RS10105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EYB66_RS10120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EYB66_RS10140	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EYB66_RS10155	COG0375	protein maturation
EYB66_RS10180	COG0778	Nitroreductase
EYB66_RS10185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYB66_RS10200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYB66_RS10200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYB66_RS10210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EYB66_RS10210	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EYB66_RS10230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS10235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EYB66_RS10240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EYB66_RS10300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYB66_RS10305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYB66_RS10320	COG0318	PFAM AMP-dependent synthetase and ligase
EYB66_RS10345	COG0339	signal peptide processing
EYB66_RS10355	COG0018	arginyl-trna synthetase
EYB66_RS10390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EYB66_RS10395	COG0653	protein targeting
EYB66_RS10425	COG0740	serine-type endopeptidase activity
EYB66_RS10595	COG0494	nUDIX hydrolase
EYB66_RS10600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EYB66_RS10605	COG1131	(ABC) transporter
EYB66_RS10625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EYB66_RS10630	COG0564	pseudouridine synthase activity
EYB66_RS10645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EYB66_RS10650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EYB66_RS10660	COG0513	Belongs to the DEAD box helicase family
EYB66_RS10670	COG0673	inositol 2-dehydrogenase activity
EYB66_RS10705	COG1971	Probably functions as a manganese efflux pump
EYB66_RS10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYB66_RS10755	COG0442	prolyl-tRNA aminoacylation
EYB66_RS10775	COG3209	COG3209 Rhs family protein
EYB66_RS10780	COG0531	amino acid
EYB66_RS10785	COG2066	Belongs to the glutaminase family
EYB66_RS10795	COG1115	amino acid carrier protein
EYB66_RS10805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EYB66_RS10810	COG2890	protein-(glutamine-N5) methyltransferase activity
EYB66_RS10815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EYB66_RS10820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EYB66_RS10835	COG2226	methyltransferase
EYB66_RS10840	COG0534	Mate efflux family protein
EYB66_RS10885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EYB66_RS10890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EYB66_RS10895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EYB66_RS10910	COG1121	(ABC) transporter
EYB66_RS10915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EYB66_RS10920	COG3880	PFAM UvrB UvrC protein
EYB66_RS10925	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EYB66_RS10930	COG0542	response to heat
EYB66_RS10945	COG0179	Fumarylacetoacetate (FAA) hydrolase
EYB66_RS10950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EYB66_RS10965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EYB66_RS10965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EYB66_RS10975	COG0180	Tryptophanyl-tRNA synthetase
EYB66_RS10985	COG1692	metallophosphoesterase
EYB66_RS10990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EYB66_RS11080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYB66_RS11085	COG2816	NAD+ diphosphatase activity
EYB66_RS11090	COG0156	8-amino-7-oxononanoate synthase activity
EYB66_RS11105	COG3266	domain, Protein
EYB66_RS11105	COG0515	serine threonine protein kinase
EYB66_RS11270	COG1598	PFAM Uncharacterised protein family UPF0150
EYB66_RS11355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EYB66_RS11365	COG3189	MarR family transcriptional regulator
EYB66_RS11375	COG0181	hydroxymethylbilane synthase activity
EYB66_RS11380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EYB66_RS11390	COG1469	GTP cyclohydrolase I activity
EYB66_RS11395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EYB66_RS11400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EYB66_RS11405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EYB66_RS11410	COG1940	carbohydrate kinase activity
EYB66_RS11425	COG0494	nUDIX hydrolase
EYB66_RS11430	COG1566	PFAM secretion protein HlyD family protein
EYB66_RS11435	COG0577	efflux transmembrane transporter activity
EYB66_RS11435	COG1136	(ABC) transporter
EYB66_RS11440	COG0577	efflux transmembrane transporter activity
EYB66_RS11440	COG1136	(ABC) transporter
EYB66_RS11445	COG1538	Outer membrane efflux protein
EYB66_RS11460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYB66_RS11470	COG1720	tRNA m6t6A37 methyltransferase activity
EYB66_RS11475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EYB66_RS11480	COG0540	Belongs to the ATCase OTCase family
EYB66_RS11485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EYB66_RS11500	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EYB66_RS11505	COG2957	Belongs to the agmatine deiminase family
EYB66_RS11515	COG0750	zinc metalloprotease
EYB66_RS11525	COG3119	arylsulfatase activity
EYB66_RS11535	COG1918	ferrous iron import across plasma membrane
EYB66_RS11535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EYB66_RS11585	COG1475	DNA binding
EYB66_RS11620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EYB66_RS11635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYB66_RS11640	COG0601	transmembrane transport
EYB66_RS11700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EYB66_RS11705	COG1132	(ABC) transporter
EYB66_RS11710	COG1132	(ABC) transporter
EYB66_RS11725	COG1127	ABC transporter
EYB66_RS11730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EYB66_RS11760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EYB66_RS11775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EYB66_RS11780	COG0504	CTP synthase activity
EYB66_RS11785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family