locus-tag	class	description
J4O16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J4O16_RS00010	COG1131	(ABC) transporter
J4O16_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4O16_RS00035	COG0564	pseudouridine synthase activity
J4O16_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4O16_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4O16_RS00065	COG0513	Belongs to the DEAD box helicase family
J4O16_RS00075	COG0673	inositol 2-dehydrogenase activity
J4O16_RS00095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
J4O16_RS00110	COG1971	Probably functions as a manganese efflux pump
J4O16_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4O16_RS00160	COG0442	prolyl-tRNA aminoacylation
J4O16_RS00185	COG0531	amino acid
J4O16_RS00190	COG2066	Belongs to the glutaminase family
J4O16_RS00200	COG1115	amino acid carrier protein
J4O16_RS00210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4O16_RS00215	COG2890	protein-(glutamine-N5) methyltransferase activity
J4O16_RS00220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4O16_RS00225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J4O16_RS00240	COG2226	methyltransferase
J4O16_RS00245	COG0534	Mate efflux family protein
J4O16_RS00255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4O16_RS00260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4O16_RS00265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4O16_RS00270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4O16_RS00275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS00290	COG1121	(ABC) transporter
J4O16_RS00295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4O16_RS00300	COG3880	PFAM UvrB UvrC protein
J4O16_RS00305	COG3869	Catalyzes the specific phosphorylation of arginine residues in
J4O16_RS00310	COG0542	response to heat
J4O16_RS00340	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4O16_RS00345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4O16_RS00360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J4O16_RS00360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J4O16_RS00370	COG0180	Tryptophanyl-tRNA synthetase
J4O16_RS00380	COG1692	metallophosphoesterase
J4O16_RS00385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4O16_RS00400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4O16_RS00405	COG2816	NAD+ diphosphatase activity
J4O16_RS00410	COG0156	8-amino-7-oxononanoate synthase activity
J4O16_RS00425	COG0515	serine threonine protein kinase
J4O16_RS00425	COG3266	domain, Protein
J4O16_RS00465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4O16_RS00475	COG3189	MarR family transcriptional regulator
J4O16_RS00480	COG0181	hydroxymethylbilane synthase activity
J4O16_RS00485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J4O16_RS00495	COG1469	GTP cyclohydrolase I activity
J4O16_RS00500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J4O16_RS00505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4O16_RS00510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4O16_RS00515	COG1940	carbohydrate kinase activity
J4O16_RS00530	COG0494	nUDIX hydrolase
J4O16_RS00535	COG1566	PFAM secretion protein HlyD family protein
J4O16_RS00540	COG0577	efflux transmembrane transporter activity
J4O16_RS00540	COG1136	(ABC) transporter
J4O16_RS00545	COG0577	efflux transmembrane transporter activity
J4O16_RS00545	COG1136	(ABC) transporter
J4O16_RS00550	COG1538	Outer membrane efflux protein
J4O16_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4O16_RS00575	COG1720	tRNA m6t6A37 methyltransferase activity
J4O16_RS00580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4O16_RS00585	COG0540	Belongs to the ATCase OTCase family
J4O16_RS00590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J4O16_RS00605	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J4O16_RS00610	COG2957	Belongs to the agmatine deiminase family
J4O16_RS00620	COG0750	zinc metalloprotease
J4O16_RS00630	COG3119	arylsulfatase activity
J4O16_RS00640	COG1918	ferrous iron import across plasma membrane
J4O16_RS00640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J4O16_RS00690	COG1475	DNA binding
J4O16_RS00725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J4O16_RS00735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4O16_RS00740	COG0601	transmembrane transport
J4O16_RS00795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4O16_RS00800	COG1132	(ABC) transporter
J4O16_RS00805	COG1132	(ABC) transporter
J4O16_RS00820	COG1127	ABC transporter
J4O16_RS00825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J4O16_RS00855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4O16_RS00870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J4O16_RS00875	COG0504	CTP synthase activity
J4O16_RS00880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4O16_RS00905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4O16_RS00915	COG1322	Protein conserved in bacteria
J4O16_RS00920	COG0546	phosphoglycolate phosphatase activity
J4O16_RS00925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4O16_RS00935	COG4591	ABC-type transport system involved in lipoprotein release permease component
J4O16_RS00960	COG2234	aminopeptidase activity
J4O16_RS00965	COG0657	acetylesterase activity
J4O16_RS00965	COG2755	lipolytic protein G-D-S-L family
J4O16_RS00970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4O16_RS00990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4O16_RS00995	COG2267	carboxylic ester hydrolase activity
J4O16_RS01005	COG0335	large ribosomal subunit rRNA binding
J4O16_RS01015	COG0346	lactoylglutathione lyase activity
J4O16_RS01030	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J4O16_RS01035	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
J4O16_RS01040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J4O16_RS01040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J4O16_RS01045	COG0427	acetyl-CoA hydrolase
J4O16_RS01055	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J4O16_RS01065	COG0205	6-phosphofructokinase activity
J4O16_RS01075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4O16_RS01080	COG0028	Belongs to the TPP enzyme family
J4O16_RS01100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4O16_RS01115	COG0471	metal ion transport
J4O16_RS01125	COG0351	phosphomethylpyrimidine kinase
J4O16_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
J4O16_RS01185	COG0242	peptide deformylase activity
J4O16_RS01190	COG1063	alcohol dehydrogenase
J4O16_RS01200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4O16_RS01205	COG1393	Belongs to the ArsC family
J4O16_RS01210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J4O16_RS01215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4O16_RS01225	COG1187	pseudouridine synthase activity
J4O16_RS01235	COG0336	Belongs to the RNA methyltransferase TrmD family
J4O16_RS01250	COG0539	negative regulation of cytoplasmic translation
J4O16_RS01295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J4O16_RS01300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4O16_RS01305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4O16_RS01310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4O16_RS01350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4O16_RS01370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J4O16_RS01370	COG0662	Cupin 2, conserved barrel domain protein
J4O16_RS01380	COG0416	fatty acid biosynthetic process
J4O16_RS01385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J4O16_RS01395	COG0537	adenosine 5'-monophosphoramidase activity
J4O16_RS01400	COG0009	L-threonylcarbamoyladenylate synthase
J4O16_RS01405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4O16_RS01410	COG0228	four-way junction DNA binding
J4O16_RS01435	COG1862	Preprotein translocase
J4O16_RS01440	COG0343	queuine tRNA-ribosyltransferase activity
J4O16_RS01445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4O16_RS01455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4O16_RS01460	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J4O16_RS01465	COG0776	regulation of translation
J4O16_RS01495	COG0811	peptide transport
J4O16_RS01510	COG3250	beta-galactosidase activity
J4O16_RS01515	COG0525	valine-tRNA ligase activity
J4O16_RS01525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4O16_RS01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4O16_RS01535	COG0255	Belongs to the universal ribosomal protein uL29 family
J4O16_RS01540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J4O16_RS01545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J4O16_RS01550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J4O16_RS01560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J4O16_RS01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J4O16_RS01570	COG0089	rRNA binding
J4O16_RS01575	COG0088	Forms part of the polypeptide exit tunnel
J4O16_RS01580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J4O16_RS01585	COG0051	transcription antitermination factor activity, RNA binding
J4O16_RS01590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4O16_RS01595	COG0049	tRNA binding
J4O16_RS01600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J4O16_RS01605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J4O16_RS01615	COG3852	Histidine kinase
J4O16_RS01620	COG2204	response regulator
J4O16_RS01630	COG1722	exodeoxyribonuclease VII activity
J4O16_RS01635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J4O16_RS01650	COG0795	lipopolysaccharide-transporting ATPase activity
J4O16_RS01655	COG1160	GTP binding
J4O16_RS01660	COG0444	Belongs to the ABC transporter superfamily
J4O16_RS01730	COG1136	(ABC) transporter
J4O16_RS01730	COG0577	efflux transmembrane transporter activity
J4O16_RS01740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4O16_RS01785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4O16_RS01790	COG0799	negative regulation of ribosome biogenesis
J4O16_RS01795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4O16_RS01845	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J4O16_RS01860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J4O16_RS01870	COG0300	oxidoreductase activity
J4O16_RS01890	COG0038	chloride channel
J4O16_RS01900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS01915	COG0076	glutamate decarboxylase activity
J4O16_RS01930	COG0167	dihydroorotate dehydrogenase activity
J4O16_RS01935	COG0352	thiamine-phosphate diphosphorylase activity
J4O16_RS01955	COG1253	flavin adenine dinucleotide binding
J4O16_RS01960	COG1253	flavin adenine dinucleotide binding
J4O16_RS01965	COG1185	polyribonucleotide nucleotidyltransferase activity
J4O16_RS01970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J4O16_RS01975	COG0110	maltose O-acetyltransferase activity
J4O16_RS02000	COG0101	tRNA pseudouridine synthase activity
J4O16_RS02005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J4O16_RS02020	COG4968	Prepilin-type N-terminal cleavage methylation domain
J4O16_RS02035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS02040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J4O16_RS02060	COG1136	(ABC) transporter
J4O16_RS02065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J4O16_RS02075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4O16_RS02105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J4O16_RS02110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J4O16_RS02120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J4O16_RS02125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J4O16_RS02135	COG2814	Major facilitator Superfamily
J4O16_RS02145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4O16_RS02150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4O16_RS02150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4O16_RS02155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J4O16_RS02160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4O16_RS02165	COG0552	protein localization to endoplasmic reticulum
J4O16_RS02170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J4O16_RS02190	COG1546	Belongs to the CinA family
J4O16_RS02190	COG1058	Belongs to the CinA family
J4O16_RS02200	COG0456	acetyltransferase
J4O16_RS02225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4O16_RS02230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J4O16_RS02235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4O16_RS02240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4O16_RS02255	COG0758	DNA mediated transformation
J4O16_RS02260	COG1686	Belongs to the peptidase S11 family
J4O16_RS02265	COG0012	GTP binding
J4O16_RS02270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J4O16_RS02280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4O16_RS02280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4O16_RS02295	COG3119	arylsulfatase activity
J4O16_RS02320	COG2259	Doxx family
J4O16_RS02325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4O16_RS02355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4O16_RS02375	COG2326	polyphosphate kinase activity
J4O16_RS02380	COG1349	DNA-binding transcription factor activity
J4O16_RS02395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4O16_RS02400	COG1162	GTPase activity
J4O16_RS02415	COG0742	ribosomal rna small subunit methyltransferase
J4O16_RS02430	COG2326	polyphosphate kinase activity
J4O16_RS02440	COG5434	Belongs to the glycosyl hydrolase 28 family
J4O16_RS02450	COG1073	alpha beta
J4O16_RS02455	COG0802	atpase or kinase
J4O16_RS02460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J4O16_RS02465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4O16_RS02470	COG0735	belongs to the Fur family
J4O16_RS02475	COG0396	ATPase activity
J4O16_RS02480	COG0719	Fe-S assembly protein
J4O16_RS02485	COG0719	Fe-S assembly protein
J4O16_RS02500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J4O16_RS02545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J4O16_RS02565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4O16_RS02570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4O16_RS02575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4O16_RS02580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4O16_RS02585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4O16_RS02590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4O16_RS02600	COG0356	it plays a direct role in the translocation of protons across the membrane
J4O16_RS02650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4O16_RS02675	COG1045	serine acetyltransferase
J4O16_RS02680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J4O16_RS02685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4O16_RS02690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4O16_RS02700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4O16_RS02710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4O16_RS02715	COG0047	phosphoribosylformylglycinamidine synthase activity
J4O16_RS02725	COG1363	Peptidase, m42
J4O16_RS02740	COG1077	Cell shape determining protein MreB Mrl
J4O16_RS02745	COG1530	ribonuclease E activity
J4O16_RS02770	COG0848	biopolymer transport protein
J4O16_RS02785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4O16_RS02800	COG0134	indole-3-glycerol-phosphate synthase activity
J4O16_RS02805	COG0792	nuclease activity
J4O16_RS02815	COG1253	flavin adenine dinucleotide binding
J4O16_RS02825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4O16_RS02830	COG0137	argininosuccinate synthase activity
J4O16_RS02850	COG0149	triose-phosphate isomerase activity
J4O16_RS02885	COG1040	competence protein
J4O16_RS02895	COG3956	TIGRFAM MazG family protein
J4O16_RS02915	COG1663	tetraacyldisaccharide 4'-kinase activity
J4O16_RS02920	COG0612	Peptidase, M16
J4O16_RS02945	COG0673	inositol 2-dehydrogenase activity
J4O16_RS02950	COG3034	peptidoglycan biosynthetic process
J4O16_RS02970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4O16_RS02975	COG0424	maF-like protein
J4O16_RS02980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4O16_RS03010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J4O16_RS03020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J4O16_RS03030	COG0571	ribonuclease III activity
J4O16_RS03040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J4O16_RS03080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J4O16_RS03095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J4O16_RS03115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4O16_RS03120	COG0631	protein serine/threonine phosphatase activity
J4O16_RS03130	COG2226	methyltransferase
J4O16_RS03140	COG2076	Multidrug Resistance protein
J4O16_RS03180	COG2255	four-way junction helicase activity
J4O16_RS03185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4O16_RS03190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4O16_RS03195	COG1215	transferase activity, transferring glycosyl groups
J4O16_RS03200	COG1216	Glycosyl transferase, family 2
J4O16_RS03200	COG0463	Glycosyl transferase, family 2
J4O16_RS03225	COG0438	transferase activity, transferring glycosyl groups
J4O16_RS03235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4O16_RS03245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J4O16_RS03255	COG0482	sulfurtransferase activity
J4O16_RS03260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J4O16_RS03270	COG2860	membrane
J4O16_RS03275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J4O16_RS03280	COG2001	Belongs to the MraZ family
J4O16_RS03285	COG0275	rRNA processing
J4O16_RS03295	COG0768	penicillin binding
J4O16_RS03300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J4O16_RS03305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4O16_RS03310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4O16_RS03315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J4O16_RS03325	COG0772	Belongs to the SEDS family
J4O16_RS03330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4O16_RS03335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4O16_RS03340	COG1181	Belongs to the D-alanine--D-alanine ligase family
J4O16_RS03350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J4O16_RS03355	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4O16_RS03360	COG0321	lipoyl(octanoyl) transferase activity
J4O16_RS03365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J4O16_RS03370	COG0066	3-isopropylmalate dehydratase activity
J4O16_RS03380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4O16_RS03390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4O16_RS03395	COG4608	Belongs to the ABC transporter superfamily
J4O16_RS03400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J4O16_RS03405	COG0052	Belongs to the universal ribosomal protein uS2 family
J4O16_RS03415	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J4O16_RS03430	COG1137	ATPase activity
J4O16_RS03440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4O16_RS03455	COG1733	regulation of RNA biosynthetic process
J4O16_RS03480	COG0017	Asparaginyl-tRNA synthetase
J4O16_RS03490	COG3118	belongs to the thioredoxin family
J4O16_RS03540	COG0583	DNA-binding transcription factor activity
J4O16_RS03545	COG2855	membrane
J4O16_RS03550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4O16_RS03560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4O16_RS03570	COG0602	queuosine metabolic process
J4O16_RS03575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J4O16_RS03580	COG0217	transcriptional regulatory protein
J4O16_RS03585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4O16_RS03590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4O16_RS03590	COG4651	solute:proton antiporter activity
J4O16_RS03600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J4O16_RS03605	COG4864	UPF0365 protein
J4O16_RS03615	COG2022	thiamine diphosphate biosynthetic process
J4O16_RS03620	COG0531	amino acid
J4O16_RS03630	COG0628	permease
J4O16_RS03635	COG0019	diaminopimelate decarboxylase activity
J4O16_RS03640	COG0191	fructose-bisphosphate aldolase activity
J4O16_RS03645	COG1217	gtp-binding protein TYPA
J4O16_RS03675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4O16_RS03715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4O16_RS03720	COG0517	IMP dehydrogenase activity
J4O16_RS03720	COG0516	GMP reductase activity
J4O16_RS03725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4O16_RS03725	COG0519	Catalyzes the synthesis of GMP from XMP
J4O16_RS03735	COG0546	phosphoglycolate phosphatase activity
J4O16_RS03755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4O16_RS03770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J4O16_RS03775	COG0196	riboflavin kinase activity
J4O16_RS03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J4O16_RS03795	COG1408	metallophosphoesterase
J4O16_RS03805	COG1216	Glycosyl transferase, family 2
J4O16_RS03805	COG1442	glycosyl transferase family 8
J4O16_RS03815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4O16_RS03820	COG1216	Glycosyl transferase, family 2
J4O16_RS03840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4O16_RS03840	COG2755	lipolytic protein G-D-S-L family
J4O16_RS03855	COG0471	metal ion transport
J4O16_RS03855	COG0490	domain, Protein
J4O16_RS03895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4O16_RS03905	COG0477	Major facilitator Superfamily
J4O16_RS03910	COG1607	acyl-coa hydrolase
J4O16_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
J4O16_RS03930	COG1525	nuclease
J4O16_RS03945	COG1475	DNA binding
J4O16_RS03950	COG3969	phosphoadenosine phosphosulfate
J4O16_RS03960	COG0473	3-isopropylmalate dehydrogenase activity
J4O16_RS03985	COG2873	o-acetylhomoserine
J4O16_RS03990	COG0535	radical SAM domain protein
J4O16_RS03995	COG0535	radical SAM domain protein
J4O16_RS04010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4O16_RS04015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J4O16_RS04025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J4O16_RS04030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J4O16_RS04030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J4O16_RS04030	COG1013	pyruvate-flavodoxin oxidoreductase activity
J4O16_RS04030	COG0674	pyruvate-flavodoxin oxidoreductase activity
J4O16_RS04040	COG1733	regulation of RNA biosynthetic process
J4O16_RS04050	COG0107	imidazoleglycerol-phosphate synthase activity
J4O16_RS04060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4O16_RS04070	COG1643	Atp-dependent helicase
J4O16_RS04075	COG0440	acetolactate synthase activity
J4O16_RS04080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4O16_RS04090	COG0445	tRNA wobble uridine modification
J4O16_RS04095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4O16_RS04095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4O16_RS04100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J4O16_RS04110	COG0592	DNA-directed DNA polymerase activity
J4O16_RS04135	COG0791	NLP P60 protein
J4O16_RS04135	COG1388	LysM domain
J4O16_RS04140	COG0084	hydrolase, TatD family'
J4O16_RS04150	COG3250	beta-galactosidase activity
J4O16_RS04165	COG2205	protein histidine kinase activity
J4O16_RS04170	COG0745	RESPONSE REGULATOR receiver
J4O16_RS04180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J4O16_RS04205	COG0542	response to heat
J4O16_RS04250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4O16_RS04260	COG0659	secondary active sulfate transmembrane transporter activity
J4O16_RS04265	COG0165	Argininosuccinate lyase
J4O16_RS04280	COG0148	phosphopyruvate hydratase activity
J4O16_RS04285	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J4O16_RS04295	COG3481	metal-dependent phosphohydrolase, HD sub domain
J4O16_RS04305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4O16_RS04310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4O16_RS04340	COG0490	domain, Protein
J4O16_RS04340	COG2985	domain, Protein
J4O16_RS04355	COG0471	metal ion transport
J4O16_RS04380	COG2194	sulfuric ester hydrolase activity
J4O16_RS04385	COG1592	Rubrerythrin
J4O16_RS04395	COG1363	Peptidase, m42
J4O16_RS04400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS04410	COG1785	Belongs to the alkaline phosphatase family
J4O16_RS04415	COG1970	mechanosensitive ion channel activity
J4O16_RS04420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4O16_RS04430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4O16_RS04440	COG2217	Heavy metal translocating P-type atpase
J4O16_RS04445	COG0497	DNA recombination
J4O16_RS04450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J4O16_RS04450	COG0321	lipoyl(octanoyl) transferase activity
J4O16_RS04455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J4O16_RS04485	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4O16_RS04490	COG0022	dehydrogenase e1 component
J4O16_RS04495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J4O16_RS04500	COG0789	Transcriptional regulator
J4O16_RS04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4O16_RS04510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4O16_RS04575	COG3409	Peptidoglycan-binding domain 1 protein
J4O16_RS04575	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4O16_RS04580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4O16_RS04605	COG1690	Belongs to the RtcB family
J4O16_RS04615	COG2814	Major facilitator Superfamily
J4O16_RS04625	COG2096	Adenosyltransferase
J4O16_RS04635	COG0557	exoribonuclease II activity
J4O16_RS04650	COG0826	peptidase U32
J4O16_RS04655	COG0285	dihydrofolate synthase activity
J4O16_RS04670	COG0673	inositol 2-dehydrogenase activity
J4O16_RS04675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4O16_RS04680	COG0737	Belongs to the 5'-nucleotidase family
J4O16_RS04690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4O16_RS04695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J4O16_RS04710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J4O16_RS04715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J4O16_RS04720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J4O16_RS04725	COG0200	Binds to the 23S rRNA
J4O16_RS04730	COG0201	protein transport
J4O16_RS04735	COG0563	adenylate kinase activity
J4O16_RS04740	COG0024	Methionine aminopeptidase
J4O16_RS04755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J4O16_RS04760	COG1442	glycosyl transferase family 8
J4O16_RS04770	COG1216	Glycosyl transferase, family 2
J4O16_RS04780	COG1216	Glycosyl transferase, family 2
J4O16_RS04790	COG1216	Glycosyl transferase, family 2
J4O16_RS04795	COG0693	protein deglycase activity
J4O16_RS04800	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4O16_RS04805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4O16_RS04810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4O16_RS04820	COG1966	Carbon starvation protein
J4O16_RS04830	COG3119	arylsulfatase activity
J4O16_RS04835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J4O16_RS04840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J4O16_RS04845	COG0195	Participates in both transcription termination and antitermination
J4O16_RS04850	COG0708	Exodeoxyribonuclease III
J4O16_RS04855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4O16_RS04860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J4O16_RS04865	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4O16_RS04875	COG1716	ATPase activity
J4O16_RS04875	COG1131	(ABC) transporter
J4O16_RS04875	COG0842	Transport permease protein
J4O16_RS04895	COG0724	RNA recognition motif
J4O16_RS04900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4O16_RS04920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J4O16_RS04930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J4O16_RS04935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4O16_RS04950	COG1490	D-aminoacyl-tRNA deacylase activity
J4O16_RS04975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4O16_RS04980	COG1053	succinate dehydrogenase
J4O16_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
J4O16_RS05035	COG0488	(ABC) transporter
J4O16_RS05045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4O16_RS05055	COG1253	flavin adenine dinucleotide binding
J4O16_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
J4O16_RS05070	COG1073	alpha beta
J4O16_RS05135	COG2267	carboxylic ester hydrolase activity
J4O16_RS05140	COG2095	MarC family integral membrane protein
J4O16_RS05180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4O16_RS05185	COG0488	(ABC) transporter
J4O16_RS05195	COG0697	spore germination
J4O16_RS05205	COG0215	cysteine-tRNA ligase activity
J4O16_RS05215	COG3119	arylsulfatase activity
J4O16_RS05230	COG0481	GTPase activity
J4O16_RS05245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J4O16_RS05250	COG0085	RNA polymerase activity
J4O16_RS05255	COG0222	ribosome binding
J4O16_RS05260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J4O16_RS05265	COG0081	regulation of translation
J4O16_RS05270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J4O16_RS05275	COG0250	Participates in transcription elongation, termination and antitermination
J4O16_RS05290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J4O16_RS05300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J4O16_RS05310	COG0740	serine-type endopeptidase activity
J4O16_RS05315	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4O16_RS05330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4O16_RS05350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4O16_RS05390	COG2226	methyltransferase
J4O16_RS05395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J4O16_RS05400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J4O16_RS05415	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4O16_RS05415	COG1902	pentaerythritol trinitrate reductase activity
J4O16_RS05425	COG3119	arylsulfatase activity
J4O16_RS05430	COG0514	ATP-dependent DNA helicase (RecQ)
J4O16_RS05450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J4O16_RS05455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4O16_RS05495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J4O16_RS05510	COG1858	cytochrome C peroxidase
J4O16_RS05515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J4O16_RS05520	COG0590	tRNA wobble adenosine to inosine editing
J4O16_RS05525	COG1940	carbohydrate kinase activity
J4O16_RS05530	COG2217	Heavy metal translocating P-type atpase
J4O16_RS05535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J4O16_RS05540	COG0237	dephospho-CoA kinase activity
J4O16_RS05570	COG1363	Peptidase, m42
J4O16_RS05575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J4O16_RS05585	COG0006	proline dipeptidase activity
J4O16_RS05590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4O16_RS05600	COG0745	RESPONSE REGULATOR receiver
J4O16_RS05605	COG0129	dihydroxy-acid dehydratase activity
J4O16_RS05630	COG1368	sulfuric ester hydrolase activity
J4O16_RS05665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4O16_RS05670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4O16_RS05690	COG0534	Mate efflux family protein
J4O16_RS05695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4O16_RS05710	COG1876	peptidase activity
J4O16_RS05755	COG3209	COG3209 Rhs family protein
J4O16_RS05805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J4O16_RS05810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J4O16_RS05815	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
J4O16_RS05820	COG2205	protein histidine kinase activity
J4O16_RS05825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4O16_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4O16_RS05850	COG0667	Aldo Keto reductase
J4O16_RS05855	COG0789	Transcriptional regulator
J4O16_RS05900	COG0714	Associated with various cellular activities
J4O16_RS05905	COG2311	Membrane
J4O16_RS05925	COG1090	epimerase
J4O16_RS05935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J4O16_RS05940	COG1119	ATPase activity
J4O16_RS05945	COG2186	Transcriptional regulator
J4O16_RS05965	COG0148	phosphopyruvate hydratase activity
J4O16_RS05970	COG0436	Aminotransferase
J4O16_RS05975	COG1477	protein flavinylation
J4O16_RS05990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J4O16_RS06000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4O16_RS06020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J4O16_RS06030	COG1199	ATP-dependent helicase activity
J4O16_RS06035	COG1122	ATPase activity
J4O16_RS06060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4O16_RS06065	COG0598	Magnesium transport protein CorA
J4O16_RS06070	COG0359	binds to the 23S rRNA
J4O16_RS06075	COG0138	bifunctional purine biosynthesis protein purh
J4O16_RS06080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J4O16_RS06085	COG0736	holo-[acyl-carrier-protein] synthase activity
J4O16_RS06095	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J4O16_RS06100	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4O16_RS06100	COG3409	Peptidoglycan-binding domain 1 protein
J4O16_RS06105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4O16_RS06115	COG0437	4 iron, 4 sulfur cluster binding
J4O16_RS06135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4O16_RS06185	COG0284	orotidine-5'-phosphate decarboxylase activity
J4O16_RS06205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J4O16_RS06210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4O16_RS06230	COG2003	Belongs to the UPF0758 family
J4O16_RS06235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4O16_RS06235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J4O16_RS06240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J4O16_RS06245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J4O16_RS06250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4O16_RS06255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J4O16_RS06260	COG0322	excinuclease ABC activity
J4O16_RS06265	COG0811	peptide transport
J4O16_RS06270	COG0848	biopolymer transport protein
J4O16_RS06280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J4O16_RS06285	COG0483	inositol monophosphate 1-phosphatase activity
J4O16_RS06290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J4O16_RS06300	COG1482	cell wall glycoprotein biosynthetic process
J4O16_RS06310	COG1757	Na H antiporter
J4O16_RS06315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4O16_RS06320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
J4O16_RS06325	COG0505	Belongs to the CarA family
J4O16_RS06330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4O16_RS06345	COG0067	glutamate synthase
J4O16_RS06345	COG0069	glutamate synthase activity
J4O16_RS06345	COG0070	glutamate synthase
J4O16_RS06355	COG0706	membrane insertase activity
J4O16_RS06360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J4O16_RS06370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J4O16_RS06380	COG0657	acetylesterase activity
J4O16_RS06380	COG2755	lipolytic protein G-D-S-L family
J4O16_RS06390	COG0676	glucose-6-phosphate 1-epimerase activity
J4O16_RS06395	COG0259	pyridoxamine-phosphate oxidase activity
J4O16_RS06410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4O16_RS06430	COG1760	l-serine dehydratase
J4O16_RS06435	COG0492	ferredoxin-NADP+ reductase activity
J4O16_RS06435	COG3118	belongs to the thioredoxin family
J4O16_RS06485	COG1408	metallophosphoesterase
J4O16_RS06495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4O16_RS06500	COG0545	Peptidyl-prolyl cis-trans isomerase
J4O16_RS06515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4O16_RS06525	COG0826	peptidase U32
J4O16_RS06530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J4O16_RS06550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4O16_RS06560	COG1116	anion transmembrane transporter activity
J4O16_RS06570	COG0529	Catalyzes the synthesis of activated sulfate
J4O16_RS06570	COG2895	sulfate adenylyltransferase (ATP) activity
J4O16_RS06575	COG0175	sulfate reduction
J4O16_RS06580	COG0175	sulfate reduction
J4O16_RS06600	COG0581	inorganic phosphate transmembrane transporter activity
J4O16_RS06605	COG0573	inorganic phosphate transmembrane transporter activity
J4O16_RS06615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4O16_RS06625	COG2017	converts alpha-aldose to the beta-anomer
J4O16_RS06640	COG0612	Peptidase, M16
J4O16_RS06670	COG0233	cytoplasmic translational termination
J4O16_RS06675	COG0528	UMP kinase activity
J4O16_RS06680	COG0668	transmembrane transport
J4O16_RS06685	COG0450	alkyl hydroperoxide reductase
J4O16_RS06690	COG0733	neurotransmitter:sodium symporter activity
J4O16_RS06705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4O16_RS06715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4O16_RS06720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4O16_RS06725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4O16_RS06955	COG0305	Participates in initiation and elongation during chromosome replication
J4O16_RS06970	COG0842	Transport permease protein
J4O16_RS06975	COG0842	Transport permease protein
J4O16_RS06980	COG1131	(ABC) transporter
J4O16_RS06990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4O16_RS06995	COG1183	phosphatidylcholine synthase activity
J4O16_RS07005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4O16_RS07015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J4O16_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
J4O16_RS07040	COG0156	8-amino-7-oxononanoate synthase activity
J4O16_RS07060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J4O16_RS07065	COG0124	histidyl-tRNA synthetase
J4O16_RS07070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J4O16_RS07075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
J4O16_RS07080	COG0298	carbon dioxide binding
J4O16_RS07105	COG0438	transferase activity, transferring glycosyl groups
J4O16_RS07110	COG0443	Heat shock 70 kDa protein
J4O16_RS07115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J4O16_RS07120	COG0459	protein refolding
J4O16_RS07170	COG0632	four-way junction helicase activity
J4O16_RS07180	COG0126	phosphoglycerate kinase activity
J4O16_RS07190	COG1082	Xylose isomerase domain protein TIM barrel
J4O16_RS07195	COG2815	serine threonine protein kinase
J4O16_RS07195	COG0515	serine threonine protein kinase
J4O16_RS07200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4O16_RS07210	COG2271	Major facilitator Superfamily
J4O16_RS07225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J4O16_RS07235	COG0037	tRNA processing
J4O16_RS07240	COG0254	rRNA binding
J4O16_RS07275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J4O16_RS07280	COG0039	L-malate dehydrogenase activity
J4O16_RS07300	COG0778	Nitroreductase
J4O16_RS07305	COG0564	pseudouridine synthase activity
J4O16_RS07325	COG1126	abc transporter atp-binding protein
J4O16_RS07330	COG0765	amino acid transport
J4O16_RS07340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J4O16_RS07345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J4O16_RS07365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4O16_RS07390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J4O16_RS07395	COG1872	DUF167
J4O16_RS07400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4O16_RS07405	COG0484	heat shock protein binding
J4O16_RS07410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4O16_RS07420	COG5434	Belongs to the glycosyl hydrolase 28 family
J4O16_RS07435	COG0277	FAD linked oxidase domain protein
J4O16_RS07460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4O16_RS07465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J4O16_RS07475	COG0131	Imidazoleglycerol-phosphate dehydratase
J4O16_RS07480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4O16_RS07485	COG0360	Binds together with S18 to 16S ribosomal RNA
J4O16_RS07490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J4O16_RS07505	COG1686	Belongs to the peptidase S11 family
J4O16_RS07510	COG0205	6-phosphofructokinase activity
J4O16_RS07520	COG0428	transporter
J4O16_RS07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4O16_RS07540	COG3977	Valine--pyruvate aminotransferase
J4O16_RS07545	COG1561	YicC-like family, N-terminal region
J4O16_RS07555	COG0471	metal ion transport
J4O16_RS07555	COG3273	potassium ion transport
J4O16_RS07560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4O16_RS07575	COG1575	Belongs to the MenA family. Type 1 subfamily
J4O16_RS07610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4O16_RS07610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4O16_RS07630	COG0202	RNA polymerase activity
J4O16_RS07635	COG0203	ribosomal protein L17
J4O16_RS07640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J4O16_RS07645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4O16_RS07660	COG2885	chlorophyll binding
J4O16_RS07695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4O16_RS07735	COG0667	Aldo Keto reductase
J4O16_RS07740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J4O16_RS07755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4O16_RS07760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4O16_RS07765	COG0134	indole-3-glycerol-phosphate synthase activity
J4O16_RS07770	COG0135	phosphoribosylanthranilate isomerase activity
J4O16_RS07780	COG0159	tryptophan synthase activity
J4O16_RS07795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4O16_RS07800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4O16_RS07810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4O16_RS07840	COG0561	phosphatase activity
J4O16_RS07845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4O16_RS07850	COG2223	nitrite transmembrane transporter activity
J4O16_RS07865	COG0556	nucleotide-excision repair
J4O16_RS07870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J4O16_RS07875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J4O16_RS07880	COG0750	zinc metalloprotease
J4O16_RS07895	COG1074	ATP-dependent DNA helicase activity
J4O16_RS07905	COG0697	spore germination
J4O16_RS07915	COG2373	Large extracellular alpha-helical protein
J4O16_RS07920	COG1979	alcohol dehydrogenase
J4O16_RS07930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4O16_RS07955	COG0372	Belongs to the citrate synthase family
J4O16_RS07970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J4O16_RS07980	COG1187	pseudouridine synthase activity
J4O16_RS07990	COG0105	UTP biosynthetic process
J4O16_RS07995	COG1215	transferase activity, transferring glycosyl groups
J4O16_RS08000	COG0463	Glycosyl transferase, family 2
J4O16_RS08010	COG1459	type II secretion system
J4O16_RS08015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4O16_RS08020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4O16_RS08025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4O16_RS08040	COG0728	peptidoglycan biosynthetic process
J4O16_RS08045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4O16_RS08045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J4O16_RS08055	COG1649	PFAM Uncharacterised BCR, COG1649
J4O16_RS08060	COG1691	(AIR) carboxylase
J4O16_RS08065	COG0037	tRNA processing
J4O16_RS08070	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
J4O16_RS08075	COG0142	geranyltranstransferase activity
J4O16_RS08090	COG2151	metal-sulfur cluster biosynthetic enzyme
J4O16_RS08110	COG1007	ATP synthesis coupled electron transport
J4O16_RS08115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4O16_RS08125	COG0713	ATP synthesis coupled electron transport
J4O16_RS08130	COG0839	Belongs to the complex I subunit 6 family
J4O16_RS08140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J4O16_RS08145	COG1034	ATP synthesis coupled electron transport
J4O16_RS08150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J4O16_RS08155	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J4O16_RS08160	COG0649	NAD binding
J4O16_RS08170	COG0726	polysaccharide deacetylase
J4O16_RS08180	COG0307	riboflavin synthase, alpha
J4O16_RS08185	COG2264	protein methyltransferase activity
J4O16_RS08190	COG3210	domain, Protein
J4O16_RS08195	COG1640	4-alpha-glucanotransferase
J4O16_RS08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4O16_RS08210	COG1030	water channel activity
J4O16_RS08215	COG0358	DNA primase activity
J4O16_RS08220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4O16_RS08225	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
J4O16_RS08240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J4O16_RS08245	COG0793	Belongs to the peptidase S41A family
J4O16_RS08260	COG1643	Atp-dependent helicase
J4O16_RS08285	COG1450	Type ii and iii secretion system protein
J4O16_RS08300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4O16_RS08320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4O16_RS08325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J4O16_RS08335	COG0268	Binds directly to 16S ribosomal RNA
J4O16_RS08340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4O16_RS08345	COG0028	Belongs to the TPP enzyme family
J4O16_RS08355	COG0688	phosphatidylethanolamine metabolic process
J4O16_RS08360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4O16_RS08365	COG0495	leucyl-tRNA aminoacylation
J4O16_RS08370	COG3119	arylsulfatase activity
J4O16_RS08385	COG1166	arginine decarboxylase activity
J4O16_RS08425	COG3250	beta-galactosidase activity
J4O16_RS08430	COG3250	beta-galactosidase activity
J4O16_RS08435	COG3250	beta-galactosidase activity
J4O16_RS08440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4O16_RS08445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS08455	COG0205	6-phosphofructokinase activity
J4O16_RS08505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J4O16_RS08510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J4O16_RS08515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
J4O16_RS08525	COG4771	TonB-dependent receptor
J4O16_RS08545	COG0402	S-adenosylhomocysteine deaminase activity
J4O16_RS08550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4O16_RS08575	COG1294	oxidase, subunit
J4O16_RS08580	COG1271	oxidase subunit
J4O16_RS08590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4O16_RS08610	COG1846	Transcriptional regulator
J4O16_RS08635	COG2949	membrane
J4O16_RS08660	COG0514	ATP-dependent DNA helicase (RecQ)
J4O16_RS08675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J4O16_RS08680	COG0045	succinate-CoA ligase (ADP-forming) activity
J4O16_RS08685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J4O16_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4O16_RS08745	COG2205	protein histidine kinase activity
J4O16_RS08760	COG0113	porphobilinogen synthase activity
J4O16_RS08770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J4O16_RS08790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J4O16_RS08830	COG3475	LICD family
J4O16_RS08835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4O16_RS08845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J4O16_RS08850	COG3475	LICD family
J4O16_RS08855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4O16_RS08865	COG2166	iron-sulfur cluster assembly
J4O16_RS08870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4O16_RS08880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4O16_RS08885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4O16_RS08890	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J4O16_RS08895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4O16_RS08900	COG1131	(ABC) transporter
J4O16_RS08915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4O16_RS08930	COG1215	transferase activity, transferring glycosyl groups
J4O16_RS08940	COG2967	ApaG domain
J4O16_RS08950	COG1522	sequence-specific DNA binding
J4O16_RS08955	COG0436	Aminotransferase
J4O16_RS08970	COG0423	glycine-tRNA ligase activity
J4O16_RS08975	COG0656	L-ascorbic acid biosynthetic process
J4O16_RS08990	COG2304	oxidoreductase activity
J4O16_RS09005	COG0714	Associated with various cellular activities
J4O16_RS09010	COG0154	amidase activity
J4O16_RS09015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4O16_RS09055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4O16_RS09065	COG2755	lipolytic protein G-D-S-L family
J4O16_RS09065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4O16_RS09085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J4O16_RS09095	COG0656	L-ascorbic acid biosynthetic process
J4O16_RS09105	COG0667	Aldo Keto reductase
J4O16_RS09110	COG1408	metallophosphoesterase
J4O16_RS09130	COG0667	Aldo Keto reductase
J4O16_RS09140	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4O16_RS09145	COG0789	Transcriptional regulator
J4O16_RS09160	COG0534	Mate efflux family protein
J4O16_RS09180	COG1091	dTDP-4-dehydrorhamnose reductase activity
J4O16_RS09195	COG1837	Belongs to the UPF0109 family
J4O16_RS09200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4O16_RS09205	COG0363	glucosamine-6-phosphate deaminase activity
J4O16_RS09225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J4O16_RS09235	COG1741	Belongs to the pirin family
J4O16_RS09250	COG1070	Carbohydrate kinase
J4O16_RS09265	COG0738	Major facilitator superfamily
J4O16_RS09280	COG1595	DNA-templated transcription, initiation
J4O16_RS09295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J4O16_RS09320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4O16_RS09335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J4O16_RS09345	COG2132	Multicopper oxidase
J4O16_RS09350	COG0697	spore germination
J4O16_RS09360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4O16_RS09365	COG4608	Belongs to the ABC transporter superfamily
J4O16_RS09370	COG0444	Belongs to the ABC transporter superfamily
J4O16_RS09375	COG4166	transmembrane transport
J4O16_RS09380	COG4239	(ABC) transporter, permease
J4O16_RS09385	COG0601	transmembrane transport
J4O16_RS09405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4O16_RS09410	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J4O16_RS09415	COG3738	Protein conserved in bacteria
J4O16_RS09420	COG0151	Belongs to the GarS family
J4O16_RS09435	COG0811	peptide transport
J4O16_RS09445	COG0242	peptide deformylase activity
J4O16_RS09480	COG2010	Cytochrome c
J4O16_RS09490	COG3258	Cytochrome c
J4O16_RS09500	COG3274	enterobacterial common antigen metabolic process
J4O16_RS09505	COG0538	isocitrate dehydrogenase activity
J4O16_RS09520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
J4O16_RS09525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4O16_RS09530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J4O16_RS09540	COG0668	transmembrane transport
J4O16_RS09545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4O16_RS09545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
J4O16_RS09550	COG0805	protein transport
J4O16_RS09555	COG1968	undecaprenyl-diphosphatase activity
J4O16_RS09575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4O16_RS09585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4O16_RS09595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4O16_RS09605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4O16_RS09615	COG1408	metallophosphoesterase
J4O16_RS09640	COG4974	Belongs to the 'phage' integrase family
J4O16_RS09665	COG1454	alcohol dehydrogenase
J4O16_RS09670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J4O16_RS09685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4O16_RS09695	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J4O16_RS09695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4O16_RS09700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J4O16_RS09740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4O16_RS09750	COG4607	ABC-type enterochelin transport system periplasmic component
J4O16_RS09755	COG4604	ABC transporter, ATP-binding protein
J4O16_RS09760	COG4605	iron ion homeostasis
J4O16_RS09765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4O16_RS09800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4O16_RS09800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4O16_RS09815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4O16_RS09820	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4O16_RS09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4O16_RS09855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4O16_RS09880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4O16_RS09880	COG0519	Catalyzes the synthesis of GMP from XMP
J4O16_RS09885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4O16_RS09915	COG1410	methionine synthase
J4O16_RS09915	COG0646	methionine synthase
J4O16_RS09920	COG2966	Psort location CytoplasmicMembrane, score
J4O16_RS09925	COG3610	response to peptide
J4O16_RS09935	COG0460	homoserine dehydrogenase
J4O16_RS09940	COG0527	aspartate kinase activity
J4O16_RS09950	COG5522	Integral membrane protein (intg_mem_TP0381)
J4O16_RS09960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4O16_RS09965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4O16_RS09970	COG1194	a g-specific adenine glycosylase
J4O16_RS09975	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J4O16_RS09980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4O16_RS09980	COG0574	Belongs to the PEP-utilizing enzyme family
J4O16_RS09985	COG0166	Belongs to the GPI family
J4O16_RS09995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4O16_RS10005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J4O16_RS10005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J4O16_RS10015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J4O16_RS10015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J4O16_RS10050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4O16_RS10055	COG2818	Glycosylase
J4O16_RS10075	COG3033	Beta-eliminating lyase
J4O16_RS10090	COG0072	phenylalanine-tRNA ligase activity
J4O16_RS10090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4O16_RS10110	COG0326	Molecular chaperone. Has ATPase activity
J4O16_RS10115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4O16_RS10135	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J4O16_RS10150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4O16_RS10155	COG1959	2 iron, 2 sulfur cluster binding
J4O16_RS10170	COG0352	thiamine-phosphate diphosphorylase activity
J4O16_RS10175	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J4O16_RS10200	COG1703	isobutyryl-CoA mutase activity
J4O16_RS10220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J4O16_RS10230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4O16_RS10235	COG0418	dihydroorotase activity
J4O16_RS10250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4O16_RS10270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4O16_RS10285	COG0534	Mate efflux family protein
J4O16_RS10290	COG0489	protein tyrosine kinase activity
J4O16_RS10300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4O16_RS10305	COG0339	signal peptide processing
J4O16_RS10310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4O16_RS10320	COG1538	Outer membrane efflux protein
J4O16_RS10335	COG4112	unkown
J4O16_RS10350	COG0038	chloride channel
J4O16_RS10360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4O16_RS10365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J4O16_RS10370	COG0586	Pfam SNARE associated Golgi protein
J4O16_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
J4O16_RS10455	COG0753	catalase activity
J4O16_RS10465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4O16_RS10470	COG1592	Rubrerythrin
J4O16_RS10475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4O16_RS10485	COG1674	ftsk spoiiie
J4O16_RS10495	COG0489	protein tyrosine kinase activity
J4O16_RS10505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4O16_RS10515	COG0438	transferase activity, transferring glycosyl groups
J4O16_RS10525	COG0438	transferase activity, transferring glycosyl groups
J4O16_RS10565	COG0110	maltose O-acetyltransferase activity
J4O16_RS10575	COG1216	Glycosyl transferase, family 2
J4O16_RS10595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4O16_RS10595	COG2755	lipolytic protein G-D-S-L family
J4O16_RS10615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J4O16_RS10620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4O16_RS10620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4O16_RS10625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J4O16_RS10635	COG0280	phosphate acetyltransferase
J4O16_RS10635	COG0281	malic enzyme
J4O16_RS10650	COG1472	Belongs to the glycosyl hydrolase 3 family
J4O16_RS10655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4O16_RS10670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4O16_RS10680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J4O16_RS10685	COG1063	alcohol dehydrogenase
J4O16_RS10700	COG0714	Associated with various cellular activities
J4O16_RS10710	COG0193	aminoacyl-tRNA hydrolase activity
J4O16_RS10715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4O16_RS10730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J4O16_RS10750	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J4O16_RS10765	COG0375	protein maturation
J4O16_RS10790	COG0778	Nitroreductase
J4O16_RS10795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J4O16_RS10815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4O16_RS10815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4O16_RS10825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
J4O16_RS10825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J4O16_RS10845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4O16_RS10850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4O16_RS10855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J4O16_RS10890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4O16_RS10895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J4O16_RS10910	COG0318	PFAM AMP-dependent synthetase and ligase
J4O16_RS10940	COG0339	signal peptide processing
J4O16_RS10950	COG0018	arginyl-trna synthetase
J4O16_RS10990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4O16_RS10995	COG0653	protein targeting
J4O16_RS11010	COG0494	nUDIX hydrolase