locus-tag	class	description
FU653_RS00010	COG1131	(ABC) transporter
FU653_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FU653_RS00035	COG0564	pseudouridine synthase activity
FU653_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FU653_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FU653_RS00065	COG0513	Belongs to the DEAD box helicase family
FU653_RS00075	COG0673	inositol 2-dehydrogenase activity
FU653_RS00095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FU653_RS00110	COG1971	Probably functions as a manganese efflux pump
FU653_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FU653_RS00160	COG0442	prolyl-tRNA aminoacylation
FU653_RS00185	COG0531	amino acid
FU653_RS00190	COG2066	Belongs to the glutaminase family
FU653_RS00200	COG1115	amino acid carrier protein
FU653_RS00210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FU653_RS00215	COG2890	protein-(glutamine-N5) methyltransferase activity
FU653_RS00220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FU653_RS00225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FU653_RS00240	COG2226	methyltransferase
FU653_RS00245	COG0534	Mate efflux family protein
FU653_RS00255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FU653_RS00260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FU653_RS00265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FU653_RS00270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FU653_RS00275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS00290	COG1121	(ABC) transporter
FU653_RS00295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FU653_RS00300	COG3880	PFAM UvrB UvrC protein
FU653_RS00305	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FU653_RS00310	COG0542	response to heat
FU653_RS00340	COG0179	Fumarylacetoacetate (FAA) hydrolase
FU653_RS00345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FU653_RS00360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FU653_RS00360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FU653_RS00370	COG0180	Tryptophanyl-tRNA synthetase
FU653_RS00380	COG1692	metallophosphoesterase
FU653_RS00385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FU653_RS00400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FU653_RS00405	COG2816	NAD+ diphosphatase activity
FU653_RS00410	COG0156	8-amino-7-oxononanoate synthase activity
FU653_RS00425	COG0515	serine threonine protein kinase
FU653_RS00425	COG3266	domain, Protein
FU653_RS00465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FU653_RS00475	COG3189	MarR family transcriptional regulator
FU653_RS00485	COG0181	hydroxymethylbilane synthase activity
FU653_RS00490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FU653_RS00500	COG1469	GTP cyclohydrolase I activity
FU653_RS00505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FU653_RS00510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FU653_RS00515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FU653_RS00520	COG1940	carbohydrate kinase activity
FU653_RS00535	COG0494	nUDIX hydrolase
FU653_RS00540	COG1566	PFAM secretion protein HlyD family protein
FU653_RS00545	COG0577	efflux transmembrane transporter activity
FU653_RS00545	COG1136	(ABC) transporter
FU653_RS00550	COG1136	(ABC) transporter
FU653_RS00550	COG0577	efflux transmembrane transporter activity
FU653_RS00555	COG1538	Outer membrane efflux protein
FU653_RS00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FU653_RS00580	COG1720	tRNA m6t6A37 methyltransferase activity
FU653_RS00585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FU653_RS00590	COG0540	Belongs to the ATCase OTCase family
FU653_RS00595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FU653_RS00610	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FU653_RS00615	COG2957	Belongs to the agmatine deiminase family
FU653_RS00625	COG0750	zinc metalloprotease
FU653_RS00635	COG3119	arylsulfatase activity
FU653_RS00645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FU653_RS00645	COG1918	ferrous iron import across plasma membrane
FU653_RS00695	COG1475	DNA binding
FU653_RS00730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FU653_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FU653_RS00750	COG0601	transmembrane transport
FU653_RS00805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FU653_RS00810	COG1132	(ABC) transporter
FU653_RS00815	COG1132	(ABC) transporter
FU653_RS00830	COG1127	ABC transporter
FU653_RS00835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FU653_RS00865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FU653_RS00880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FU653_RS00885	COG0504	CTP synthase activity
FU653_RS00890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FU653_RS00915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS00925	COG1322	Protein conserved in bacteria
FU653_RS00930	COG0546	phosphoglycolate phosphatase activity
FU653_RS00935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FU653_RS00945	COG4591	ABC-type transport system involved in lipoprotein release permease component
FU653_RS00970	COG2234	aminopeptidase activity
FU653_RS00975	COG2755	lipolytic protein G-D-S-L family
FU653_RS00975	COG0657	acetylesterase activity
FU653_RS00980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FU653_RS01000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FU653_RS01005	COG2267	carboxylic ester hydrolase activity
FU653_RS01015	COG0335	large ribosomal subunit rRNA binding
FU653_RS01025	COG0346	lactoylglutathione lyase activity
FU653_RS01040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FU653_RS01045	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FU653_RS01050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FU653_RS01050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FU653_RS01055	COG0427	acetyl-CoA hydrolase
FU653_RS01065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FU653_RS01075	COG0205	6-phosphofructokinase activity
FU653_RS01085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FU653_RS01090	COG0028	Belongs to the TPP enzyme family
FU653_RS01110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FU653_RS01125	COG0471	metal ion transport
FU653_RS01135	COG0351	phosphomethylpyrimidine kinase
FU653_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
FU653_RS01200	COG0242	peptide deformylase activity
FU653_RS01205	COG1063	alcohol dehydrogenase
FU653_RS01215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FU653_RS01220	COG1393	Belongs to the ArsC family
FU653_RS01225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FU653_RS01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FU653_RS01240	COG1187	pseudouridine synthase activity
FU653_RS01250	COG0336	Belongs to the RNA methyltransferase TrmD family
FU653_RS01255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FU653_RS01265	COG0539	negative regulation of cytoplasmic translation
FU653_RS01310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FU653_RS01315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FU653_RS01320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FU653_RS01325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FU653_RS01365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FU653_RS01385	COG0662	Cupin 2, conserved barrel domain protein
FU653_RS01385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FU653_RS01395	COG0416	fatty acid biosynthetic process
FU653_RS01400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FU653_RS01410	COG0537	adenosine 5'-monophosphoramidase activity
FU653_RS01415	COG0009	L-threonylcarbamoyladenylate synthase
FU653_RS01420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FU653_RS01425	COG0228	four-way junction DNA binding
FU653_RS01450	COG1862	Preprotein translocase
FU653_RS01455	COG0343	queuine tRNA-ribosyltransferase activity
FU653_RS01460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FU653_RS01470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FU653_RS01475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FU653_RS01480	COG0776	regulation of translation
FU653_RS01510	COG0811	peptide transport
FU653_RS01525	COG3250	beta-galactosidase activity
FU653_RS01530	COG0525	valine-tRNA ligase activity
FU653_RS01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FU653_RS01545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FU653_RS01550	COG0255	Belongs to the universal ribosomal protein uL29 family
FU653_RS01555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FU653_RS01560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FU653_RS01565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FU653_RS01575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FU653_RS01580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FU653_RS01585	COG0089	rRNA binding
FU653_RS01590	COG0088	Forms part of the polypeptide exit tunnel
FU653_RS01595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FU653_RS01600	COG0051	transcription antitermination factor activity, RNA binding
FU653_RS01605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FU653_RS01610	COG0049	tRNA binding
FU653_RS01615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FU653_RS01620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FU653_RS01630	COG3852	Histidine kinase
FU653_RS01635	COG2204	response regulator
FU653_RS01645	COG1722	exodeoxyribonuclease VII activity
FU653_RS01650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FU653_RS01665	COG0795	lipopolysaccharide-transporting ATPase activity
FU653_RS01670	COG1160	GTP binding
FU653_RS01675	COG0444	Belongs to the ABC transporter superfamily
FU653_RS01745	COG0577	efflux transmembrane transporter activity
FU653_RS01745	COG1136	(ABC) transporter
FU653_RS01755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FU653_RS01800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FU653_RS01805	COG0799	negative regulation of ribosome biogenesis
FU653_RS01810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FU653_RS01860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FU653_RS01875	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FU653_RS01885	COG0300	oxidoreductase activity
FU653_RS01905	COG0038	chloride channel
FU653_RS01915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS01930	COG0076	glutamate decarboxylase activity
FU653_RS01945	COG0167	dihydroorotate dehydrogenase activity
FU653_RS01950	COG0352	thiamine-phosphate diphosphorylase activity
FU653_RS01970	COG1253	flavin adenine dinucleotide binding
FU653_RS01975	COG1253	flavin adenine dinucleotide binding
FU653_RS01980	COG1185	polyribonucleotide nucleotidyltransferase activity
FU653_RS01985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FU653_RS01990	COG0110	maltose O-acetyltransferase activity
FU653_RS02015	COG0101	tRNA pseudouridine synthase activity
FU653_RS02020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FU653_RS02035	COG4968	Prepilin-type N-terminal cleavage methylation domain
FU653_RS02050	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS02055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FU653_RS02070	COG1136	(ABC) transporter
FU653_RS02075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FU653_RS02085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FU653_RS02115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FU653_RS02120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FU653_RS02130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FU653_RS02135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FU653_RS02145	COG2814	Major facilitator Superfamily
FU653_RS02155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FU653_RS02160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FU653_RS02160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FU653_RS02165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FU653_RS02170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FU653_RS02175	COG0552	protein localization to endoplasmic reticulum
FU653_RS02180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FU653_RS02200	COG1546	Belongs to the CinA family
FU653_RS02200	COG1058	Belongs to the CinA family
FU653_RS02210	COG0456	acetyltransferase
FU653_RS02235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FU653_RS02240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FU653_RS02245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FU653_RS02250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FU653_RS02265	COG0758	DNA mediated transformation
FU653_RS02270	COG1686	Belongs to the peptidase S11 family
FU653_RS02275	COG0012	GTP binding
FU653_RS02280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FU653_RS02290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FU653_RS02290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FU653_RS02305	COG3119	arylsulfatase activity
FU653_RS02330	COG2259	Doxx family
FU653_RS02335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FU653_RS02365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FU653_RS02385	COG2326	polyphosphate kinase activity
FU653_RS02390	COG1349	DNA-binding transcription factor activity
FU653_RS02405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FU653_RS02410	COG1162	GTPase activity
FU653_RS02425	COG0742	ribosomal rna small subunit methyltransferase
FU653_RS02440	COG2326	polyphosphate kinase activity
FU653_RS02450	COG5434	Belongs to the glycosyl hydrolase 28 family
FU653_RS02460	COG1073	alpha beta
FU653_RS02465	COG0802	atpase or kinase
FU653_RS02470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FU653_RS02475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FU653_RS02480	COG0735	belongs to the Fur family
FU653_RS02485	COG0396	ATPase activity
FU653_RS02490	COG0719	Fe-S assembly protein
FU653_RS02495	COG0719	Fe-S assembly protein
FU653_RS02510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FU653_RS02555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FU653_RS02575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FU653_RS02580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FU653_RS02585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FU653_RS02590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FU653_RS02595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FU653_RS02600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FU653_RS02610	COG0356	it plays a direct role in the translocation of protons across the membrane
FU653_RS02660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FU653_RS02685	COG1045	serine acetyltransferase
FU653_RS02690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FU653_RS02695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FU653_RS02700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FU653_RS02710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FU653_RS02720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FU653_RS02725	COG0047	phosphoribosylformylglycinamidine synthase activity
FU653_RS02735	COG1363	Peptidase, m42
FU653_RS02750	COG1077	Cell shape determining protein MreB Mrl
FU653_RS02755	COG1530	ribonuclease E activity
FU653_RS02780	COG0848	biopolymer transport protein
FU653_RS02795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FU653_RS02810	COG0134	indole-3-glycerol-phosphate synthase activity
FU653_RS02815	COG0792	nuclease activity
FU653_RS02825	COG1253	flavin adenine dinucleotide binding
FU653_RS02835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FU653_RS02840	COG0137	argininosuccinate synthase activity
FU653_RS02860	COG0149	triose-phosphate isomerase activity
FU653_RS02895	COG1040	competence protein
FU653_RS02905	COG3956	TIGRFAM MazG family protein
FU653_RS02925	COG1663	tetraacyldisaccharide 4'-kinase activity
FU653_RS02930	COG0612	Peptidase, M16
FU653_RS02955	COG0673	inositol 2-dehydrogenase activity
FU653_RS02960	COG3034	peptidoglycan biosynthetic process
FU653_RS02980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FU653_RS02985	COG0424	maF-like protein
FU653_RS02990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FU653_RS03020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FU653_RS03030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FU653_RS03040	COG0571	ribonuclease III activity
FU653_RS03050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FU653_RS03095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FU653_RS03110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FU653_RS03130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FU653_RS03135	COG0631	protein serine/threonine phosphatase activity
FU653_RS03145	COG2226	methyltransferase
FU653_RS03155	COG2076	Multidrug Resistance protein
FU653_RS03195	COG2255	four-way junction helicase activity
FU653_RS03200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FU653_RS03205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FU653_RS03210	COG1215	transferase activity, transferring glycosyl groups
FU653_RS03215	COG1216	Glycosyl transferase, family 2
FU653_RS03215	COG0463	Glycosyl transferase, family 2
FU653_RS03240	COG0438	transferase activity, transferring glycosyl groups
FU653_RS03250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FU653_RS03260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FU653_RS03270	COG0482	sulfurtransferase activity
FU653_RS03275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FU653_RS03285	COG2860	membrane
FU653_RS03290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FU653_RS03295	COG2001	Belongs to the MraZ family
FU653_RS03300	COG0275	rRNA processing
FU653_RS03310	COG0768	penicillin binding
FU653_RS03315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FU653_RS03320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FU653_RS03325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FU653_RS03330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FU653_RS03340	COG0772	Belongs to the SEDS family
FU653_RS03345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FU653_RS03350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FU653_RS03355	COG1181	Belongs to the D-alanine--D-alanine ligase family
FU653_RS03365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FU653_RS03370	COG0860	N-Acetylmuramoyl-L-alanine amidase
FU653_RS03375	COG0321	lipoyl(octanoyl) transferase activity
FU653_RS03380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FU653_RS03385	COG0066	3-isopropylmalate dehydratase activity
FU653_RS03395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS03405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FU653_RS03410	COG4608	Belongs to the ABC transporter superfamily
FU653_RS03415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FU653_RS03420	COG0052	Belongs to the universal ribosomal protein uS2 family
FU653_RS03430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FU653_RS03445	COG1137	ATPase activity
FU653_RS03455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FU653_RS03470	COG1733	regulation of RNA biosynthetic process
FU653_RS03495	COG0017	Asparaginyl-tRNA synthetase
FU653_RS03505	COG3118	belongs to the thioredoxin family
FU653_RS03555	COG0583	DNA-binding transcription factor activity
FU653_RS03560	COG2855	membrane
FU653_RS03565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FU653_RS03575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FU653_RS03585	COG0602	queuosine metabolic process
FU653_RS03590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FU653_RS03595	COG0217	transcriptional regulatory protein
FU653_RS03600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FU653_RS03605	COG4651	solute:proton antiporter activity
FU653_RS03605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FU653_RS03615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FU653_RS03620	COG4864	UPF0365 protein
FU653_RS03630	COG2022	thiamine diphosphate biosynthetic process
FU653_RS03635	COG0531	amino acid
FU653_RS03645	COG0628	permease
FU653_RS03650	COG0019	diaminopimelate decarboxylase activity
FU653_RS03655	COG0191	fructose-bisphosphate aldolase activity
FU653_RS03660	COG1217	gtp-binding protein TYPA
FU653_RS03690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FU653_RS03730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FU653_RS03735	COG0516	GMP reductase activity
FU653_RS03735	COG0517	IMP dehydrogenase activity
FU653_RS03740	COG0519	Catalyzes the synthesis of GMP from XMP
FU653_RS03740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FU653_RS03750	COG0546	phosphoglycolate phosphatase activity
FU653_RS03770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FU653_RS03785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FU653_RS03790	COG0196	riboflavin kinase activity
FU653_RS03795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FU653_RS03810	COG1408	metallophosphoesterase
FU653_RS03820	COG1442	glycosyl transferase family 8
FU653_RS03820	COG1216	Glycosyl transferase, family 2
FU653_RS03830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FU653_RS03835	COG1216	Glycosyl transferase, family 2
FU653_RS03855	COG2755	lipolytic protein G-D-S-L family
FU653_RS03855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FU653_RS03870	COG0471	metal ion transport
FU653_RS03870	COG0490	domain, Protein
FU653_RS03905	COG0588	phosphoglycerate mutase activity
FU653_RS03915	COG0477	Major facilitator Superfamily
FU653_RS03920	COG1607	acyl-coa hydrolase
FU653_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
FU653_RS03940	COG1525	nuclease
FU653_RS03955	COG1475	DNA binding
FU653_RS03960	COG3969	phosphoadenosine phosphosulfate
FU653_RS03975	COG0473	3-isopropylmalate dehydrogenase activity
FU653_RS04000	COG2873	o-acetylhomoserine
FU653_RS04005	COG0535	radical SAM domain protein
FU653_RS04010	COG0535	radical SAM domain protein
FU653_RS04025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FU653_RS04030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FU653_RS04040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FU653_RS04045	COG1013	pyruvate-flavodoxin oxidoreductase activity
FU653_RS04045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FU653_RS04045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FU653_RS04045	COG0674	pyruvate-flavodoxin oxidoreductase activity
FU653_RS04055	COG1733	regulation of RNA biosynthetic process
FU653_RS04065	COG0107	imidazoleglycerol-phosphate synthase activity
FU653_RS04070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FU653_RS04080	COG1643	Atp-dependent helicase
FU653_RS04085	COG0440	acetolactate synthase activity
FU653_RS04090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS04100	COG0445	tRNA wobble uridine modification
FU653_RS04105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FU653_RS04105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FU653_RS04110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FU653_RS04120	COG0592	DNA-directed DNA polymerase activity
FU653_RS04145	COG1388	LysM domain
FU653_RS04145	COG0791	NLP P60 protein
FU653_RS04150	COG0084	hydrolase, TatD family'
FU653_RS04160	COG3250	beta-galactosidase activity
FU653_RS04175	COG2205	protein histidine kinase activity
FU653_RS04180	COG0745	RESPONSE REGULATOR receiver
FU653_RS04190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FU653_RS04220	COG0542	response to heat
FU653_RS04265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FU653_RS04275	COG0659	secondary active sulfate transmembrane transporter activity
FU653_RS04280	COG0165	Argininosuccinate lyase
FU653_RS04295	COG0148	phosphopyruvate hydratase activity
FU653_RS04300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FU653_RS04310	COG3481	metal-dependent phosphohydrolase, HD sub domain
FU653_RS04320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FU653_RS04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FU653_RS04355	COG0490	domain, Protein
FU653_RS04355	COG2985	domain, Protein
FU653_RS04370	COG0471	metal ion transport
FU653_RS04400	COG2194	sulfuric ester hydrolase activity
FU653_RS04405	COG1592	Rubrerythrin
FU653_RS04415	COG1363	Peptidase, m42
FU653_RS04420	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS04425	COG1785	Belongs to the alkaline phosphatase family
FU653_RS04430	COG1970	mechanosensitive ion channel activity
FU653_RS04435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FU653_RS04445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FU653_RS04455	COG2217	Heavy metal translocating P-type atpase
FU653_RS04460	COG0497	DNA recombination
FU653_RS04465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FU653_RS04465	COG0321	lipoyl(octanoyl) transferase activity
FU653_RS04470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FU653_RS04495	COG0508	dehydrogenase complex catalyzes the overall conversion of
FU653_RS04500	COG0022	dehydrogenase e1 component
FU653_RS04505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FU653_RS04510	COG0789	Transcriptional regulator
FU653_RS04515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FU653_RS04520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FU653_RS04580	COG5632	N-Acetylmuramoyl-L-alanine amidase
FU653_RS04580	COG3409	Peptidoglycan-binding domain 1 protein
FU653_RS04585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FU653_RS04610	COG1690	Belongs to the RtcB family
FU653_RS04620	COG2814	Major facilitator Superfamily
FU653_RS04630	COG2096	Adenosyltransferase
FU653_RS04640	COG0557	exoribonuclease II activity
FU653_RS04655	COG0826	peptidase U32
FU653_RS04660	COG0285	dihydrofolate synthase activity
FU653_RS04675	COG0673	inositol 2-dehydrogenase activity
FU653_RS04680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FU653_RS04685	COG0737	Belongs to the 5'-nucleotidase family
FU653_RS04695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FU653_RS04700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FU653_RS04715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FU653_RS04720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FU653_RS04725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FU653_RS04730	COG0200	Binds to the 23S rRNA
FU653_RS04735	COG0201	protein transport
FU653_RS04740	COG0563	adenylate kinase activity
FU653_RS04745	COG0024	Methionine aminopeptidase
FU653_RS04760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FU653_RS04765	COG1442	glycosyl transferase family 8
FU653_RS04775	COG1216	Glycosyl transferase, family 2
FU653_RS04785	COG1216	Glycosyl transferase, family 2
FU653_RS04795	COG1216	Glycosyl transferase, family 2
FU653_RS04800	COG0693	protein deglycase activity
FU653_RS04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
FU653_RS04810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FU653_RS04815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FU653_RS04825	COG1966	Carbon starvation protein
FU653_RS04835	COG3119	arylsulfatase activity
FU653_RS04840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FU653_RS04845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FU653_RS04850	COG0195	Participates in both transcription termination and antitermination
FU653_RS04855	COG0708	Exodeoxyribonuclease III
FU653_RS04860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FU653_RS04865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FU653_RS04870	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
FU653_RS04880	COG1716	ATPase activity
FU653_RS04880	COG0842	Transport permease protein
FU653_RS04880	COG1131	(ABC) transporter
FU653_RS04900	COG0724	RNA recognition motif
FU653_RS04905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FU653_RS04925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FU653_RS04935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FU653_RS04940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FU653_RS04955	COG1490	D-aminoacyl-tRNA deacylase activity
FU653_RS04980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FU653_RS04985	COG1053	succinate dehydrogenase
FU653_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
FU653_RS05040	COG0488	(ABC) transporter
FU653_RS05050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FU653_RS05060	COG1253	flavin adenine dinucleotide binding
FU653_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
FU653_RS05075	COG1073	alpha beta
FU653_RS05140	COG2267	carboxylic ester hydrolase activity
FU653_RS05145	COG2095	MarC family integral membrane protein
FU653_RS05185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FU653_RS05190	COG0488	(ABC) transporter
FU653_RS05200	COG0697	spore germination
FU653_RS05210	COG0215	cysteine-tRNA ligase activity
FU653_RS05220	COG3119	arylsulfatase activity
FU653_RS05230	COG0481	GTPase activity
FU653_RS05245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FU653_RS05250	COG0085	RNA polymerase activity
FU653_RS05255	COG0222	ribosome binding
FU653_RS05260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FU653_RS05265	COG0081	regulation of translation
FU653_RS05270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FU653_RS05275	COG0250	Participates in transcription elongation, termination and antitermination
FU653_RS05290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FU653_RS05300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FU653_RS05310	COG0740	serine-type endopeptidase activity
FU653_RS05315	COG0544	peptidyl-prolyl cis-trans isomerase activity
FU653_RS05330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FU653_RS05350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FU653_RS05390	COG2226	methyltransferase
FU653_RS05395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FU653_RS05400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FU653_RS05415	COG1902	pentaerythritol trinitrate reductase activity
FU653_RS05415	COG0446	pyridine nucleotide-disulphide oxidoreductase
FU653_RS05425	COG3119	arylsulfatase activity
FU653_RS05430	COG0514	ATP-dependent DNA helicase (RecQ)
FU653_RS05450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FU653_RS05455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FU653_RS05495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FU653_RS05510	COG1858	cytochrome C peroxidase
FU653_RS05515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FU653_RS05520	COG0590	tRNA wobble adenosine to inosine editing
FU653_RS05525	COG1940	carbohydrate kinase activity
FU653_RS05530	COG2217	Heavy metal translocating P-type atpase
FU653_RS05535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FU653_RS05540	COG0237	dephospho-CoA kinase activity
FU653_RS05570	COG1363	Peptidase, m42
FU653_RS05575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FU653_RS05585	COG0006	proline dipeptidase activity
FU653_RS05590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FU653_RS05605	COG0745	RESPONSE REGULATOR receiver
FU653_RS05610	COG0129	dihydroxy-acid dehydratase activity
FU653_RS05635	COG1368	sulfuric ester hydrolase activity
FU653_RS05670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FU653_RS05675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FU653_RS05700	COG0534	Mate efflux family protein
FU653_RS05705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FU653_RS05720	COG1876	peptidase activity
FU653_RS05765	COG3209	COG3209 Rhs family protein
FU653_RS05820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FU653_RS05825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FU653_RS05830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FU653_RS05835	COG2205	protein histidine kinase activity
FU653_RS05840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FU653_RS05850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FU653_RS05865	COG0667	Aldo Keto reductase
FU653_RS05870	COG0789	Transcriptional regulator
FU653_RS05915	COG0714	Associated with various cellular activities
FU653_RS05920	COG2311	Membrane
FU653_RS05940	COG1090	epimerase
FU653_RS05950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FU653_RS05955	COG1119	ATPase activity
FU653_RS05960	COG2186	Transcriptional regulator
FU653_RS05980	COG0148	phosphopyruvate hydratase activity
FU653_RS05985	COG0436	Aminotransferase
FU653_RS05990	COG1477	protein flavinylation
FU653_RS06005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FU653_RS06015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FU653_RS06035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FU653_RS06045	COG1199	ATP-dependent helicase activity
FU653_RS06050	COG1122	ATPase activity
FU653_RS06075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FU653_RS06080	COG0598	Magnesium transport protein CorA
FU653_RS06085	COG0359	binds to the 23S rRNA
FU653_RS06090	COG0138	bifunctional purine biosynthesis protein purh
FU653_RS06095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FU653_RS06100	COG0736	holo-[acyl-carrier-protein] synthase activity
FU653_RS06110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FU653_RS06115	COG3409	Peptidoglycan-binding domain 1 protein
FU653_RS06115	COG5632	N-Acetylmuramoyl-L-alanine amidase
FU653_RS06120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FU653_RS06130	COG0437	4 iron, 4 sulfur cluster binding
FU653_RS06150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FU653_RS06205	COG0284	orotidine-5'-phosphate decarboxylase activity
FU653_RS06225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FU653_RS06230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FU653_RS06250	COG2003	Belongs to the UPF0758 family
FU653_RS06255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FU653_RS06255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FU653_RS06260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FU653_RS06265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FU653_RS06270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FU653_RS06275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FU653_RS06280	COG0322	excinuclease ABC activity
FU653_RS06285	COG0811	peptide transport
FU653_RS06290	COG0848	biopolymer transport protein
FU653_RS06300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FU653_RS06305	COG0483	inositol monophosphate 1-phosphatase activity
FU653_RS06310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FU653_RS06320	COG1482	cell wall glycoprotein biosynthetic process
FU653_RS06330	COG1757	Na H antiporter
FU653_RS06335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FU653_RS06340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FU653_RS06345	COG0505	Belongs to the CarA family
FU653_RS06350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FU653_RS06365	COG0067	glutamate synthase
FU653_RS06365	COG0069	glutamate synthase activity
FU653_RS06365	COG0070	glutamate synthase
FU653_RS06375	COG0706	membrane insertase activity
FU653_RS06380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FU653_RS06390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FU653_RS06405	COG0657	acetylesterase activity
FU653_RS06405	COG2755	lipolytic protein G-D-S-L family
FU653_RS06415	COG0676	glucose-6-phosphate 1-epimerase activity
FU653_RS06420	COG0259	pyridoxamine-phosphate oxidase activity
FU653_RS06435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FU653_RS06455	COG1760	l-serine dehydratase
FU653_RS06460	COG0492	ferredoxin-NADP+ reductase activity
FU653_RS06460	COG3118	belongs to the thioredoxin family
FU653_RS06510	COG1408	metallophosphoesterase
FU653_RS06520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FU653_RS06525	COG0545	Peptidyl-prolyl cis-trans isomerase
FU653_RS06540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FU653_RS06550	COG0826	peptidase U32
FU653_RS06560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FU653_RS06580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FU653_RS06590	COG1116	anion transmembrane transporter activity
FU653_RS06600	COG0529	Catalyzes the synthesis of activated sulfate
FU653_RS06600	COG2895	sulfate adenylyltransferase (ATP) activity
FU653_RS06605	COG0175	sulfate reduction
FU653_RS06610	COG0175	sulfate reduction
FU653_RS06630	COG0581	inorganic phosphate transmembrane transporter activity
FU653_RS06635	COG0573	inorganic phosphate transmembrane transporter activity
FU653_RS06645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FU653_RS06655	COG2017	converts alpha-aldose to the beta-anomer
FU653_RS06670	COG0612	Peptidase, M16
FU653_RS06700	COG0233	cytoplasmic translational termination
FU653_RS06705	COG0528	UMP kinase activity
FU653_RS06710	COG0668	transmembrane transport
FU653_RS06715	COG0450	alkyl hydroperoxide reductase
FU653_RS06720	COG0733	neurotransmitter:sodium symporter activity
FU653_RS06735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FU653_RS06745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FU653_RS06750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FU653_RS06755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FU653_RS06975	COG0305	Participates in initiation and elongation during chromosome replication
FU653_RS06990	COG0842	Transport permease protein
FU653_RS06995	COG0842	Transport permease protein
FU653_RS07000	COG1131	(ABC) transporter
FU653_RS07010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FU653_RS07015	COG1183	phosphatidylcholine synthase activity
FU653_RS07025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FU653_RS07035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FU653_RS07040	COG1028	Short-chain dehydrogenase reductase Sdr
FU653_RS07060	COG0156	8-amino-7-oxononanoate synthase activity
FU653_RS07080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FU653_RS07085	COG0124	histidyl-tRNA synthetase
FU653_RS07090	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FU653_RS07095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FU653_RS07100	COG0298	carbon dioxide binding
FU653_RS07130	COG0443	Heat shock 70 kDa protein
FU653_RS07135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FU653_RS07140	COG0459	protein refolding
FU653_RS07190	COG0632	four-way junction helicase activity
FU653_RS07200	COG0126	phosphoglycerate kinase activity
FU653_RS07210	COG1082	Xylose isomerase domain protein TIM barrel
FU653_RS07215	COG2815	serine threonine protein kinase
FU653_RS07215	COG0515	serine threonine protein kinase
FU653_RS07220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FU653_RS07230	COG2271	Major facilitator Superfamily
FU653_RS07245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FU653_RS07255	COG0037	tRNA processing
FU653_RS07260	COG0254	rRNA binding
FU653_RS07295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FU653_RS07300	COG0039	L-malate dehydrogenase activity
FU653_RS07320	COG0778	Nitroreductase
FU653_RS07325	COG0564	pseudouridine synthase activity
FU653_RS07345	COG1126	abc transporter atp-binding protein
FU653_RS07350	COG0765	amino acid transport
FU653_RS07360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FU653_RS07365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FU653_RS07385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FU653_RS07410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FU653_RS07415	COG1872	DUF167
FU653_RS07420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FU653_RS07425	COG0484	heat shock protein binding
FU653_RS07430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FU653_RS07440	COG5434	Belongs to the glycosyl hydrolase 28 family
FU653_RS07455	COG0277	FAD linked oxidase domain protein
FU653_RS07480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FU653_RS07485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FU653_RS07495	COG0131	Imidazoleglycerol-phosphate dehydratase
FU653_RS07500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FU653_RS07505	COG0360	Binds together with S18 to 16S ribosomal RNA
FU653_RS07510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FU653_RS07525	COG1686	Belongs to the peptidase S11 family
FU653_RS07530	COG0205	6-phosphofructokinase activity
FU653_RS07540	COG0428	transporter
FU653_RS07545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FU653_RS07560	COG3977	Valine--pyruvate aminotransferase
FU653_RS07565	COG1561	YicC-like family, N-terminal region
FU653_RS07575	COG0471	metal ion transport
FU653_RS07575	COG3273	potassium ion transport
FU653_RS07580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FU653_RS07595	COG1575	Belongs to the MenA family. Type 1 subfamily
FU653_RS07630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FU653_RS07630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FU653_RS07650	COG0202	RNA polymerase activity
FU653_RS07655	COG0203	ribosomal protein L17
FU653_RS07660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FU653_RS07665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FU653_RS07680	COG2885	chlorophyll binding
FU653_RS07715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FU653_RS07755	COG0667	Aldo Keto reductase
FU653_RS07760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FU653_RS07775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FU653_RS07780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FU653_RS07785	COG0134	indole-3-glycerol-phosphate synthase activity
FU653_RS07790	COG0135	phosphoribosylanthranilate isomerase activity
FU653_RS07800	COG0159	tryptophan synthase activity
FU653_RS07815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FU653_RS07820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FU653_RS07830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FU653_RS07860	COG0561	phosphatase activity
FU653_RS07865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FU653_RS07870	COG2223	nitrite transmembrane transporter activity
FU653_RS07885	COG0556	nucleotide-excision repair
FU653_RS07890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FU653_RS07895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FU653_RS07900	COG0750	zinc metalloprotease
FU653_RS07915	COG1074	ATP-dependent DNA helicase activity
FU653_RS07925	COG0697	spore germination
FU653_RS07935	COG2373	Large extracellular alpha-helical protein
FU653_RS07940	COG1979	alcohol dehydrogenase
FU653_RS07950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FU653_RS07975	COG0372	Belongs to the citrate synthase family
FU653_RS07990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FU653_RS08000	COG1187	pseudouridine synthase activity
FU653_RS08010	COG0105	UTP biosynthetic process
FU653_RS08015	COG1215	transferase activity, transferring glycosyl groups
FU653_RS08020	COG0463	Glycosyl transferase, family 2
FU653_RS08030	COG1459	type II secretion system
FU653_RS08035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FU653_RS08040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FU653_RS08045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FU653_RS08060	COG0728	peptidoglycan biosynthetic process
FU653_RS08065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FU653_RS08065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FU653_RS08075	COG1649	PFAM Uncharacterised BCR, COG1649
FU653_RS08080	COG1691	(AIR) carboxylase
FU653_RS08085	COG0037	tRNA processing
FU653_RS08090	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FU653_RS08095	COG0142	geranyltranstransferase activity
FU653_RS08110	COG2151	metal-sulfur cluster biosynthetic enzyme
FU653_RS08125	COG1007	ATP synthesis coupled electron transport
FU653_RS08130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FU653_RS08140	COG0713	ATP synthesis coupled electron transport
FU653_RS08145	COG0839	Belongs to the complex I subunit 6 family
FU653_RS08155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FU653_RS08160	COG1034	ATP synthesis coupled electron transport
FU653_RS08165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FU653_RS08170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FU653_RS08175	COG0649	NAD binding
FU653_RS08185	COG0726	polysaccharide deacetylase
FU653_RS08195	COG0307	riboflavin synthase, alpha
FU653_RS08200	COG2264	protein methyltransferase activity
FU653_RS08205	COG3210	domain, Protein
FU653_RS08210	COG1640	4-alpha-glucanotransferase
FU653_RS08220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FU653_RS08225	COG1030	water channel activity
FU653_RS08230	COG0358	DNA primase activity
FU653_RS08235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FU653_RS08240	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FU653_RS08255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FU653_RS08260	COG0793	Belongs to the peptidase S41A family
FU653_RS08275	COG1643	Atp-dependent helicase
FU653_RS08300	COG1450	Type ii and iii secretion system protein
FU653_RS08315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FU653_RS08335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FU653_RS08340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FU653_RS08350	COG0268	Binds directly to 16S ribosomal RNA
FU653_RS08355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FU653_RS08360	COG0028	Belongs to the TPP enzyme family
FU653_RS08370	COG0688	phosphatidylethanolamine metabolic process
FU653_RS08375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FU653_RS08380	COG0495	leucyl-tRNA aminoacylation
FU653_RS08385	COG3119	arylsulfatase activity
FU653_RS08400	COG1166	arginine decarboxylase activity
FU653_RS08440	COG3250	beta-galactosidase activity
FU653_RS08445	COG3250	beta-galactosidase activity
FU653_RS08450	COG3250	beta-galactosidase activity
FU653_RS08455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FU653_RS08460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS08470	COG0205	6-phosphofructokinase activity
FU653_RS08520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FU653_RS08525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FU653_RS08530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FU653_RS08540	COG4771	TonB-dependent receptor
FU653_RS08560	COG0402	S-adenosylhomocysteine deaminase activity
FU653_RS08565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FU653_RS08590	COG1294	oxidase, subunit
FU653_RS08595	COG1271	oxidase subunit
FU653_RS08605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FU653_RS08625	COG1846	Transcriptional regulator
FU653_RS08650	COG2949	membrane
FU653_RS08680	COG0514	ATP-dependent DNA helicase (RecQ)
FU653_RS08695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FU653_RS08700	COG0045	succinate-CoA ligase (ADP-forming) activity
FU653_RS08705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FU653_RS08760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FU653_RS08765	COG2205	protein histidine kinase activity
FU653_RS08780	COG0113	porphobilinogen synthase activity
FU653_RS08790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FU653_RS08810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FU653_RS08850	COG3475	LICD family
FU653_RS08855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FU653_RS08865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FU653_RS08870	COG3475	LICD family
FU653_RS08875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FU653_RS08885	COG2166	iron-sulfur cluster assembly
FU653_RS08890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FU653_RS08900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FU653_RS08905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FU653_RS08910	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FU653_RS08915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FU653_RS08920	COG1131	(ABC) transporter
FU653_RS08935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FU653_RS08950	COG1215	transferase activity, transferring glycosyl groups
FU653_RS08960	COG2967	ApaG domain
FU653_RS08970	COG1522	sequence-specific DNA binding
FU653_RS08975	COG0436	Aminotransferase
FU653_RS08990	COG0423	glycine-tRNA ligase activity
FU653_RS08995	COG0656	L-ascorbic acid biosynthetic process
FU653_RS09010	COG2304	oxidoreductase activity
FU653_RS09025	COG0714	Associated with various cellular activities
FU653_RS09030	COG0154	amidase activity
FU653_RS09035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FU653_RS09070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS09075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS09085	COG2755	lipolytic protein G-D-S-L family
FU653_RS09085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FU653_RS09105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FU653_RS09115	COG0656	L-ascorbic acid biosynthetic process
FU653_RS09125	COG0667	Aldo Keto reductase
FU653_RS09130	COG1408	metallophosphoesterase
FU653_RS09150	COG0667	Aldo Keto reductase
FU653_RS09160	COG2249	NAD(P)H dehydrogenase (quinone) activity
FU653_RS09165	COG0789	Transcriptional regulator
FU653_RS09180	COG0534	Mate efflux family protein
FU653_RS09200	COG1091	dTDP-4-dehydrorhamnose reductase activity
FU653_RS09215	COG1837	Belongs to the UPF0109 family
FU653_RS09220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FU653_RS09225	COG0363	glucosamine-6-phosphate deaminase activity
FU653_RS09245	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FU653_RS09255	COG1741	Belongs to the pirin family
FU653_RS09270	COG1070	Carbohydrate kinase
FU653_RS09285	COG0738	Major facilitator superfamily
FU653_RS09300	COG1595	DNA-templated transcription, initiation
FU653_RS09315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FU653_RS09335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FU653_RS09350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FU653_RS09360	COG0697	spore germination
FU653_RS09370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FU653_RS09375	COG4608	Belongs to the ABC transporter superfamily
FU653_RS09380	COG0444	Belongs to the ABC transporter superfamily
FU653_RS09385	COG4166	transmembrane transport
FU653_RS09390	COG4239	(ABC) transporter, permease
FU653_RS09395	COG0601	transmembrane transport
FU653_RS09415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FU653_RS09420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FU653_RS09425	COG3738	Protein conserved in bacteria
FU653_RS09430	COG0151	Belongs to the GarS family
FU653_RS09445	COG0811	peptide transport
FU653_RS09455	COG0242	peptide deformylase activity
FU653_RS09490	COG2010	Cytochrome c
FU653_RS09500	COG3258	Cytochrome c
FU653_RS09510	COG3274	enterobacterial common antigen metabolic process
FU653_RS09515	COG0538	isocitrate dehydrogenase activity
FU653_RS09530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FU653_RS09535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FU653_RS09540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FU653_RS09550	COG0668	transmembrane transport
FU653_RS09555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FU653_RS09555	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FU653_RS09560	COG0805	protein transport
FU653_RS09565	COG1968	undecaprenyl-diphosphatase activity
FU653_RS09585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FU653_RS09595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FU653_RS09605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FU653_RS09615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FU653_RS09625	COG1408	metallophosphoesterase
FU653_RS09650	COG4974	Belongs to the 'phage' integrase family
FU653_RS09675	COG1454	alcohol dehydrogenase
FU653_RS09685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FU653_RS09700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FU653_RS09710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FU653_RS09710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FU653_RS09715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FU653_RS09755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FU653_RS09765	COG4607	ABC-type enterochelin transport system periplasmic component
FU653_RS09770	COG4604	ABC transporter, ATP-binding protein
FU653_RS09775	COG4605	iron ion homeostasis
FU653_RS09780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FU653_RS09815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FU653_RS09815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FU653_RS09830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FU653_RS09835	COG2195	Cleaves the N-terminal amino acid of tripeptides
FU653_RS09855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FU653_RS09870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FU653_RS09895	COG0519	Catalyzes the synthesis of GMP from XMP
FU653_RS09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FU653_RS09900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FU653_RS09930	COG1410	methionine synthase
FU653_RS09930	COG0646	methionine synthase
FU653_RS09935	COG2966	Psort location CytoplasmicMembrane, score
FU653_RS09940	COG3610	response to peptide
FU653_RS09950	COG0460	homoserine dehydrogenase
FU653_RS09955	COG0527	aspartate kinase activity
FU653_RS09965	COG5522	Integral membrane protein (intg_mem_TP0381)
FU653_RS09975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FU653_RS09980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FU653_RS09985	COG1194	a g-specific adenine glycosylase
FU653_RS09990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FU653_RS09995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FU653_RS09995	COG0574	Belongs to the PEP-utilizing enzyme family
FU653_RS10000	COG0166	Belongs to the GPI family
FU653_RS10010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FU653_RS10025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FU653_RS10025	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FU653_RS10055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FU653_RS10060	COG2818	Glycosylase
FU653_RS10080	COG3033	Beta-eliminating lyase
FU653_RS10095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FU653_RS10095	COG0072	phenylalanine-tRNA ligase activity
FU653_RS10115	COG0326	Molecular chaperone. Has ATPase activity
FU653_RS10120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FU653_RS10140	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FU653_RS10155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FU653_RS10160	COG1959	2 iron, 2 sulfur cluster binding
FU653_RS10175	COG0352	thiamine-phosphate diphosphorylase activity
FU653_RS10180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FU653_RS10205	COG1703	isobutyryl-CoA mutase activity
FU653_RS10225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FU653_RS10235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FU653_RS10240	COG0418	dihydroorotase activity
FU653_RS10255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FU653_RS10275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FU653_RS10290	COG0534	Mate efflux family protein
FU653_RS10295	COG0489	protein tyrosine kinase activity
FU653_RS10305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FU653_RS10310	COG0339	signal peptide processing
FU653_RS10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FU653_RS10325	COG1538	Outer membrane efflux protein
FU653_RS10340	COG4112	unkown
FU653_RS10355	COG0038	chloride channel
FU653_RS10365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FU653_RS10370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FU653_RS10375	COG0586	Pfam SNARE associated Golgi protein
FU653_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
FU653_RS10460	COG0753	catalase activity
FU653_RS10470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FU653_RS10475	COG1592	Rubrerythrin
FU653_RS10480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FU653_RS10490	COG1674	ftsk spoiiie
FU653_RS10500	COG0489	protein tyrosine kinase activity
FU653_RS10510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FU653_RS10520	COG0438	transferase activity, transferring glycosyl groups
FU653_RS10530	COG0438	transferase activity, transferring glycosyl groups
FU653_RS10570	COG0110	maltose O-acetyltransferase activity
FU653_RS10580	COG1216	Glycosyl transferase, family 2
FU653_RS10600	COG2755	lipolytic protein G-D-S-L family
FU653_RS10600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FU653_RS10620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FU653_RS10625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FU653_RS10625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FU653_RS10630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FU653_RS10640	COG0281	malic enzyme
FU653_RS10640	COG0280	phosphate acetyltransferase
FU653_RS10655	COG1472	Belongs to the glycosyl hydrolase 3 family
FU653_RS10660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FU653_RS10675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FU653_RS10685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FU653_RS10690	COG1063	alcohol dehydrogenase
FU653_RS10705	COG0714	Associated with various cellular activities
FU653_RS10715	COG0193	aminoacyl-tRNA hydrolase activity
FU653_RS10720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FU653_RS10735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FU653_RS10755	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FU653_RS10770	COG0375	protein maturation
FU653_RS10795	COG0778	Nitroreductase
FU653_RS10800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FU653_RS10810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FU653_RS10810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FU653_RS10820	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FU653_RS10820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FU653_RS10840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FU653_RS10845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FU653_RS10850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FU653_RS10885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FU653_RS10890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FU653_RS10905	COG0318	PFAM AMP-dependent synthetase and ligase
FU653_RS10930	COG0339	signal peptide processing
FU653_RS10940	COG0018	arginyl-trna synthetase
FU653_RS10975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FU653_RS10980	COG0653	protein targeting
FU653_RS10995	COG0494	nUDIX hydrolase