locus-tag	class	description
CUB89_RS00055	COG1876	peptidase activity
CUB89_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUB89_RS00075	COG0534	Mate efflux family protein
CUB89_RS00100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUB89_RS00105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CUB89_RS00140	COG1368	sulfuric ester hydrolase activity
CUB89_RS00165	COG3209	COG3209 Rhs family protein
CUB89_RS00195	COG0129	dihydroxy-acid dehydratase activity
CUB89_RS00200	COG0745	RESPONSE REGULATOR receiver
CUB89_RS00220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CUB89_RS00225	COG0006	proline dipeptidase activity
CUB89_RS00235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUB89_RS00240	COG1363	Peptidase, m42
CUB89_RS00270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUB89_RS00275	COG2217	Heavy metal translocating P-type atpase
CUB89_RS00280	COG1940	carbohydrate kinase activity
CUB89_RS00285	COG0590	tRNA wobble adenosine to inosine editing
CUB89_RS00290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUB89_RS00295	COG1858	cytochrome C peroxidase
CUB89_RS00360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUB89_RS00365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CUB89_RS00390	COG0514	ATP-dependent DNA helicase (RecQ)
CUB89_RS00395	COG3119	arylsulfatase activity
CUB89_RS00405	COG1902	pentaerythritol trinitrate reductase activity
CUB89_RS00405	COG0446	pyridine nucleotide-disulphide oxidoreductase
CUB89_RS00420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CUB89_RS00425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CUB89_RS00430	COG2226	methyltransferase
CUB89_RS00475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUB89_RS00495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CUB89_RS00510	COG0544	peptidyl-prolyl cis-trans isomerase activity
CUB89_RS00515	COG0740	serine-type endopeptidase activity
CUB89_RS00525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUB89_RS00535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUB89_RS00550	COG0250	Participates in transcription elongation, termination and antitermination
CUB89_RS00555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CUB89_RS00560	COG0081	regulation of translation
CUB89_RS00565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUB89_RS00570	COG0222	ribosome binding
CUB89_RS00575	COG0085	RNA polymerase activity
CUB89_RS00580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUB89_RS00605	COG0481	GTPase activity
CUB89_RS00615	COG3119	arylsulfatase activity
CUB89_RS00625	COG0215	cysteine-tRNA ligase activity
CUB89_RS00635	COG0697	spore germination
CUB89_RS00640	COG0488	(ABC) transporter
CUB89_RS00645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUB89_RS00675	COG2095	MarC family integral membrane protein
CUB89_RS00680	COG2267	carboxylic ester hydrolase activity
CUB89_RS00740	COG0667	Aldo Keto reductase
CUB89_RS00750	COG1073	alpha beta
CUB89_RS00760	COG1028	Short-chain dehydrogenase reductase Sdr
CUB89_RS00765	COG1253	flavin adenine dinucleotide binding
CUB89_RS00780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CUB89_RS00790	COG0488	(ABC) transporter
CUB89_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
CUB89_RS00820	COG0482	sulfurtransferase activity
CUB89_RS00825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUB89_RS00835	COG2860	membrane
CUB89_RS00840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB89_RS00845	COG2001	Belongs to the MraZ family
CUB89_RS00850	COG0275	rRNA processing
CUB89_RS00860	COG0768	penicillin binding
CUB89_RS00865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUB89_RS00870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUB89_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUB89_RS00880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUB89_RS00895	COG0772	Belongs to the SEDS family
CUB89_RS00900	COG0772	Belongs to the SEDS family
CUB89_RS00905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUB89_RS00910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUB89_RS00915	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUB89_RS00925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUB89_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUB89_RS00935	COG0321	lipoyl(octanoyl) transferase activity
CUB89_RS00940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CUB89_RS00945	COG0066	3-isopropylmalate dehydratase activity
CUB89_RS00955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS00965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUB89_RS00975	COG4608	Belongs to the ABC transporter superfamily
CUB89_RS00985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUB89_RS00990	COG0052	Belongs to the universal ribosomal protein uS2 family
CUB89_RS01000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CUB89_RS01015	COG1137	ATPase activity
CUB89_RS01025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUB89_RS01055	COG0017	Asparaginyl-tRNA synthetase
CUB89_RS01065	COG3118	belongs to the thioredoxin family
CUB89_RS01110	COG0583	DNA-binding transcription factor activity
CUB89_RS01115	COG2855	membrane
CUB89_RS01120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CUB89_RS01135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUB89_RS01145	COG0602	queuosine metabolic process
CUB89_RS01150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUB89_RS01155	COG0217	transcriptional regulatory protein
CUB89_RS01160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CUB89_RS01165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUB89_RS01165	COG4651	solute:proton antiporter activity
CUB89_RS01175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUB89_RS01180	COG4864	UPF0365 protein
CUB89_RS01190	COG2022	thiamine diphosphate biosynthetic process
CUB89_RS01195	COG0531	amino acid
CUB89_RS01205	COG0628	permease
CUB89_RS01210	COG0019	diaminopimelate decarboxylase activity
CUB89_RS01215	COG0191	fructose-bisphosphate aldolase activity
CUB89_RS01220	COG1217	gtp-binding protein TYPA
CUB89_RS01255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUB89_RS01310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUB89_RS01315	COG0516	GMP reductase activity
CUB89_RS01315	COG0517	IMP dehydrogenase activity
CUB89_RS01320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUB89_RS01320	COG0519	Catalyzes the synthesis of GMP from XMP
CUB89_RS01345	COG0546	phosphoglycolate phosphatase activity
CUB89_RS01365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CUB89_RS01380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CUB89_RS01385	COG0196	riboflavin kinase activity
CUB89_RS01390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUB89_RS01405	COG1408	metallophosphoesterase
CUB89_RS01415	COG1442	glycosyl transferase family 8
CUB89_RS01415	COG1216	Glycosyl transferase, family 2
CUB89_RS01425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB89_RS01430	COG1216	Glycosyl transferase, family 2
CUB89_RS01450	COG2755	lipolytic protein G-D-S-L family
CUB89_RS01450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB89_RS01470	COG0471	metal ion transport
CUB89_RS01470	COG0490	domain, Protein
CUB89_RS01510	COG0588	phosphoglycerate mutase activity
CUB89_RS01515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CUB89_RS01525	COG0477	Major facilitator Superfamily
CUB89_RS01530	COG1607	acyl-coa hydrolase
CUB89_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
CUB89_RS01550	COG1525	nuclease
CUB89_RS01560	COG1475	DNA binding
CUB89_RS01565	COG3969	phosphoadenosine phosphosulfate
CUB89_RS01700	COG1373	ATPase (AAA superfamily
CUB89_RS01715	COG0473	3-isopropylmalate dehydrogenase activity
CUB89_RS01740	COG2873	o-acetylhomoserine
CUB89_RS01745	COG0535	radical SAM domain protein
CUB89_RS01750	COG0535	radical SAM domain protein
CUB89_RS01765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUB89_RS01770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CUB89_RS01780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUB89_RS01790	COG0674	pyruvate-flavodoxin oxidoreductase activity
CUB89_RS01790	COG1013	pyruvate-flavodoxin oxidoreductase activity
CUB89_RS01790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CUB89_RS01790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CUB89_RS01805	COG1733	regulation of RNA biosynthetic process
CUB89_RS01815	COG0107	imidazoleglycerol-phosphate synthase activity
CUB89_RS01825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUB89_RS01835	COG1643	Atp-dependent helicase
CUB89_RS01840	COG0440	acetolactate synthase activity
CUB89_RS01845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS01855	COG0445	tRNA wobble uridine modification
CUB89_RS01860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB89_RS01860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB89_RS01865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CUB89_RS01875	COG0592	DNA-directed DNA polymerase activity
CUB89_RS01900	COG1388	LysM domain
CUB89_RS01900	COG0791	NLP P60 protein
CUB89_RS01905	COG0084	hydrolase, TatD family'
CUB89_RS01915	COG3250	beta-galactosidase activity
CUB89_RS01930	COG2205	protein histidine kinase activity
CUB89_RS01935	COG0745	RESPONSE REGULATOR receiver
CUB89_RS01945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CUB89_RS01970	COG0542	response to heat
CUB89_RS02020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUB89_RS02030	COG0659	secondary active sulfate transmembrane transporter activity
CUB89_RS02035	COG0165	Argininosuccinate lyase
CUB89_RS02050	COG0148	phosphopyruvate hydratase activity
CUB89_RS02055	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CUB89_RS02065	COG3481	metal-dependent phosphohydrolase, HD sub domain
CUB89_RS02075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB89_RS02080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUB89_RS02145	COG2985	domain, Protein
CUB89_RS02145	COG0490	domain, Protein
CUB89_RS02160	COG0471	metal ion transport
CUB89_RS02185	COG2194	sulfuric ester hydrolase activity
CUB89_RS02195	COG1592	Rubrerythrin
CUB89_RS02205	COG1363	Peptidase, m42
CUB89_RS02210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS02220	COG1785	Belongs to the alkaline phosphatase family
CUB89_RS02225	COG1970	mechanosensitive ion channel activity
CUB89_RS02230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CUB89_RS02240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CUB89_RS02250	COG2217	Heavy metal translocating P-type atpase
CUB89_RS02255	COG0497	DNA recombination
CUB89_RS02260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CUB89_RS02260	COG0321	lipoyl(octanoyl) transferase activity
CUB89_RS02295	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUB89_RS02300	COG0022	dehydrogenase e1 component
CUB89_RS02305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUB89_RS02310	COG0789	Transcriptional regulator
CUB89_RS02315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB89_RS02320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUB89_RS02380	COG3409	Peptidoglycan-binding domain 1 protein
CUB89_RS02380	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUB89_RS02385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CUB89_RS02410	COG1690	Belongs to the RtcB family
CUB89_RS02420	COG2814	Major facilitator Superfamily
CUB89_RS02430	COG2096	Adenosyltransferase
CUB89_RS02440	COG0557	exoribonuclease II activity
CUB89_RS02445	COG0557	exoribonuclease II activity
CUB89_RS02470	COG0826	peptidase U32
CUB89_RS02475	COG0285	dihydrofolate synthase activity
CUB89_RS02490	COG0673	inositol 2-dehydrogenase activity
CUB89_RS02495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUB89_RS02500	COG0737	Belongs to the 5'-nucleotidase family
CUB89_RS02510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUB89_RS02515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUB89_RS02530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUB89_RS02535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUB89_RS02540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUB89_RS02545	COG0200	Binds to the 23S rRNA
CUB89_RS02550	COG0201	protein transport
CUB89_RS02555	COG0563	adenylate kinase activity
CUB89_RS02560	COG0024	Methionine aminopeptidase
CUB89_RS02575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CUB89_RS02580	COG1442	glycosyl transferase family 8
CUB89_RS02590	COG1216	Glycosyl transferase, family 2
CUB89_RS02600	COG1216	Glycosyl transferase, family 2
CUB89_RS02615	COG1216	Glycosyl transferase, family 2
CUB89_RS02620	COG0693	protein deglycase activity
CUB89_RS02625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUB89_RS02630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CUB89_RS02635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUB89_RS02645	COG1966	Carbon starvation protein
CUB89_RS02660	COG3119	arylsulfatase activity
CUB89_RS02665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUB89_RS02670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUB89_RS02675	COG0195	Participates in both transcription termination and antitermination
CUB89_RS02680	COG0708	Exodeoxyribonuclease III
CUB89_RS02685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUB89_RS02690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CUB89_RS02695	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CUB89_RS02705	COG1716	ATPase activity
CUB89_RS02705	COG0842	Transport permease protein
CUB89_RS02705	COG1131	(ABC) transporter
CUB89_RS02725	COG0724	RNA recognition motif
CUB89_RS02730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB89_RS02750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUB89_RS02760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CUB89_RS02765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUB89_RS02780	COG1490	D-aminoacyl-tRNA deacylase activity
CUB89_RS02810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUB89_RS02815	COG1053	succinate dehydrogenase
CUB89_RS02855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUB89_RS02865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB89_RS02875	COG0438	transferase activity, transferring glycosyl groups
CUB89_RS02900	COG1216	Glycosyl transferase, family 2
CUB89_RS02900	COG0463	Glycosyl transferase, family 2
CUB89_RS02905	COG1215	transferase activity, transferring glycosyl groups
CUB89_RS02910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUB89_RS02915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUB89_RS02920	COG2255	four-way junction helicase activity
CUB89_RS02990	COG2076	Multidrug Resistance protein
CUB89_RS03000	COG2226	methyltransferase
CUB89_RS03015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUB89_RS03035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CUB89_RS03050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CUB89_RS03110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CUB89_RS03120	COG0571	ribonuclease III activity
CUB89_RS03130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUB89_RS03140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUB89_RS03170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUB89_RS03175	COG0424	maF-like protein
CUB89_RS03180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CUB89_RS03205	COG3034	peptidoglycan biosynthetic process
CUB89_RS03210	COG0673	inositol 2-dehydrogenase activity
CUB89_RS03240	COG0583	DNA-binding transcription factor activity
CUB89_RS03245	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUB89_RS03250	COG0612	Peptidase, M16
CUB89_RS03260	COG1663	tetraacyldisaccharide 4'-kinase activity
CUB89_RS03285	COG3956	TIGRFAM MazG family protein
CUB89_RS03295	COG1040	competence protein
CUB89_RS03330	COG0149	triose-phosphate isomerase activity
CUB89_RS03345	COG0137	argininosuccinate synthase activity
CUB89_RS03365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CUB89_RS03375	COG1253	flavin adenine dinucleotide binding
CUB89_RS03385	COG0792	nuclease activity
CUB89_RS03395	COG0134	indole-3-glycerol-phosphate synthase activity
CUB89_RS03420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUB89_RS03435	COG0848	biopolymer transport protein
CUB89_RS03465	COG1530	ribonuclease E activity
CUB89_RS03470	COG1077	Cell shape determining protein MreB Mrl
CUB89_RS03485	COG1363	Peptidase, m42
CUB89_RS03495	COG0047	phosphoribosylformylglycinamidine synthase activity
CUB89_RS03500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUB89_RS03510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUB89_RS03525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CUB89_RS03530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CUB89_RS03535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CUB89_RS03570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CUB89_RS03620	COG0356	it plays a direct role in the translocation of protons across the membrane
CUB89_RS03630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CUB89_RS03635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUB89_RS03640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CUB89_RS03645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUB89_RS03650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUB89_RS03655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CUB89_RS03675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUB89_RS03720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CUB89_RS03735	COG0719	Fe-S assembly protein
CUB89_RS03740	COG0719	Fe-S assembly protein
CUB89_RS03745	COG0396	ATPase activity
CUB89_RS03750	COG0735	belongs to the Fur family
CUB89_RS03755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUB89_RS03760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CUB89_RS03765	COG0802	atpase or kinase
CUB89_RS03770	COG1073	alpha beta
CUB89_RS03780	COG5434	Belongs to the glycosyl hydrolase 28 family
CUB89_RS03790	COG2326	polyphosphate kinase activity
CUB89_RS03805	COG0742	ribosomal rna small subunit methyltransferase
CUB89_RS03820	COG1162	GTPase activity
CUB89_RS03825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUB89_RS03845	COG1349	DNA-binding transcription factor activity
CUB89_RS03850	COG2326	polyphosphate kinase activity
CUB89_RS03870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUB89_RS03900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CUB89_RS03905	COG2259	Doxx family
CUB89_RS03935	COG3119	arylsulfatase activity
CUB89_RS03950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB89_RS03950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB89_RS03960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CUB89_RS03965	COG0012	GTP binding
CUB89_RS03970	COG1686	Belongs to the peptidase S11 family
CUB89_RS03975	COG0758	DNA mediated transformation
CUB89_RS03990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUB89_RS03995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CUB89_RS04000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CUB89_RS04005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUB89_RS04030	COG0456	acetyltransferase
CUB89_RS04040	COG1546	Belongs to the CinA family
CUB89_RS04040	COG1058	Belongs to the CinA family
CUB89_RS04060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUB89_RS04065	COG0552	protein localization to endoplasmic reticulum
CUB89_RS04070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUB89_RS04075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CUB89_RS04080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUB89_RS04080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUB89_RS04095	COG2814	Major facilitator Superfamily
CUB89_RS04110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CUB89_RS04115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CUB89_RS04130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CUB89_RS04135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CUB89_RS04140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS04165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB89_RS04175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CUB89_RS04180	COG1136	(ABC) transporter
CUB89_RS04200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CUB89_RS04205	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS04220	COG4968	Prepilin-type N-terminal cleavage methylation domain
CUB89_RS04235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUB89_RS04240	COG0101	tRNA pseudouridine synthase activity
CUB89_RS04275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUB89_RS04280	COG1185	polyribonucleotide nucleotidyltransferase activity
CUB89_RS04290	COG1253	flavin adenine dinucleotide binding
CUB89_RS04295	COG1253	flavin adenine dinucleotide binding
CUB89_RS04315	COG0352	thiamine-phosphate diphosphorylase activity
CUB89_RS04320	COG0167	dihydroorotate dehydrogenase activity
CUB89_RS04335	COG0076	glutamate decarboxylase activity
CUB89_RS04350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS04360	COG0038	chloride channel
CUB89_RS04380	COG4221	oxidoreductase activity
CUB89_RS04390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CUB89_RS04405	COG1136	(ABC) transporter
CUB89_RS04405	COG0577	efflux transmembrane transporter activity
CUB89_RS04460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUB89_RS04465	COG0799	negative regulation of ribosome biogenesis
CUB89_RS04470	COG1674	ftsk spoiiie
CUB89_RS04530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUB89_RS04575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUB89_RS04585	COG0577	efflux transmembrane transporter activity
CUB89_RS04585	COG1136	(ABC) transporter
CUB89_RS04605	COG0444	Belongs to the ABC transporter superfamily
CUB89_RS04610	COG1160	GTP binding
CUB89_RS04615	COG0795	lipopolysaccharide-transporting ATPase activity
CUB89_RS04630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUB89_RS04635	COG1722	exodeoxyribonuclease VII activity
CUB89_RS04645	COG2204	response regulator
CUB89_RS04650	COG3852	Histidine kinase
CUB89_RS04660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUB89_RS04665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUB89_RS04670	COG0049	tRNA binding
CUB89_RS04675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUB89_RS04680	COG0051	transcription antitermination factor activity, RNA binding
CUB89_RS04685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUB89_RS04690	COG0088	Forms part of the polypeptide exit tunnel
CUB89_RS04695	COG0089	rRNA binding
CUB89_RS04700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUB89_RS04705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUB89_RS04715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CUB89_RS04720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CUB89_RS04725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CUB89_RS04730	COG0255	Belongs to the universal ribosomal protein uL29 family
CUB89_RS04735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUB89_RS04740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUB89_RS04760	COG0525	valine-tRNA ligase activity
CUB89_RS04765	COG3250	beta-galactosidase activity
CUB89_RS04785	COG0811	peptide transport
CUB89_RS04820	COG0776	regulation of translation
CUB89_RS04825	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUB89_RS04830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CUB89_RS04840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CUB89_RS04845	COG0343	queuine tRNA-ribosyltransferase activity
CUB89_RS04850	COG1862	Preprotein translocase
CUB89_RS04875	COG0228	four-way junction DNA binding
CUB89_RS04880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUB89_RS04885	COG0009	L-threonylcarbamoyladenylate synthase
CUB89_RS04890	COG0537	adenosine 5'-monophosphoramidase activity
CUB89_RS04900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CUB89_RS04905	COG0416	fatty acid biosynthetic process
CUB89_RS04915	COG0662	Cupin 2, conserved barrel domain protein
CUB89_RS04915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUB89_RS04955	COG2856	Zn peptidase
CUB89_RS05035	COG0305	Participates in initiation and elongation during chromosome replication
CUB89_RS05200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB89_RS05235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUB89_RS05240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUB89_RS05245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUB89_RS05250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CUB89_RS05295	COG0539	negative regulation of cytoplasmic translation
CUB89_RS05305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CUB89_RS05310	COG0336	Belongs to the RNA methyltransferase TrmD family
CUB89_RS05320	COG1187	pseudouridine synthase activity
CUB89_RS05330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CUB89_RS05340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB89_RS05345	COG1393	Belongs to the ArsC family
CUB89_RS05350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUB89_RS05360	COG1063	alcohol dehydrogenase
CUB89_RS05365	COG0242	peptide deformylase activity
CUB89_RS05430	COG0351	phosphomethylpyrimidine kinase
CUB89_RS05445	COG0471	metal ion transport
CUB89_RS05460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CUB89_RS05480	COG0028	Belongs to the TPP enzyme family
CUB89_RS05485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUB89_RS05495	COG0205	6-phosphofructokinase activity
CUB89_RS05505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CUB89_RS05520	COG0427	acetyl-CoA hydrolase
CUB89_RS05530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CUB89_RS05535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CUB89_RS05550	COG0346	lactoylglutathione lyase activity
CUB89_RS05560	COG0335	large ribosomal subunit rRNA binding
CUB89_RS05580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CUB89_RS05600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CUB89_RS05605	COG2755	lipolytic protein G-D-S-L family
CUB89_RS05605	COG0657	acetylesterase activity
CUB89_RS05610	COG2234	aminopeptidase activity
CUB89_RS05650	COG3209	COG3209 Rhs family protein
CUB89_RS05660	COG3209	COG3209 Rhs family protein
CUB89_RS05680	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUB89_RS05680	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUB89_RS05690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB89_RS05695	COG0546	phosphoglycolate phosphatase activity
CUB89_RS05700	COG1322	Protein conserved in bacteria
CUB89_RS05710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS05745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUB89_RS05750	COG0504	CTP synthase activity
CUB89_RS05755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CUB89_RS05770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUB89_RS05800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CUB89_RS05805	COG1127	ABC transporter
CUB89_RS05820	COG1132	(ABC) transporter
CUB89_RS05825	COG1132	(ABC) transporter
CUB89_RS05830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUB89_RS05885	COG0601	transmembrane transport
CUB89_RS05890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUB89_RS05905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CUB89_RS05940	COG1475	DNA binding
CUB89_RS06000	COG1918	ferrous iron import across plasma membrane
CUB89_RS06000	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUB89_RS06010	COG3119	arylsulfatase activity
CUB89_RS06020	COG0750	zinc metalloprotease
CUB89_RS06030	COG2957	Belongs to the agmatine deiminase family
CUB89_RS06035	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CUB89_RS06050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CUB89_RS06055	COG0540	Belongs to the ATCase OTCase family
CUB89_RS06060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CUB89_RS06065	COG1720	tRNA m6t6A37 methyltransferase activity
CUB89_RS06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB89_RS06090	COG1538	Outer membrane efflux protein
CUB89_RS06095	COG1136	(ABC) transporter
CUB89_RS06095	COG0577	efflux transmembrane transporter activity
CUB89_RS06100	COG0577	efflux transmembrane transporter activity
CUB89_RS06100	COG1136	(ABC) transporter
CUB89_RS06105	COG1566	PFAM secretion protein HlyD family protein
CUB89_RS06110	COG0494	nUDIX hydrolase
CUB89_RS06125	COG1940	carbohydrate kinase activity
CUB89_RS06130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CUB89_RS06135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUB89_RS06140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CUB89_RS06145	COG1469	GTP cyclohydrolase I activity
CUB89_RS06155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CUB89_RS06160	COG0181	hydroxymethylbilane synthase activity
CUB89_RS06170	COG3189	MarR family transcriptional regulator
CUB89_RS06185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUB89_RS06240	COG0156	8-amino-7-oxononanoate synthase activity
CUB89_RS06245	COG2816	NAD+ diphosphatase activity
CUB89_RS06250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUB89_RS06270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUB89_RS06320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUB89_RS06325	COG1692	metallophosphoesterase
CUB89_RS06335	COG0180	Tryptophanyl-tRNA synthetase
CUB89_RS06345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUB89_RS06345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CUB89_RS06360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB89_RS06365	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUB89_RS06370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CUB89_RS06400	COG0542	response to heat
CUB89_RS06405	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CUB89_RS06410	COG3880	PFAM UvrB UvrC protein
CUB89_RS06415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CUB89_RS06420	COG1121	(ABC) transporter
CUB89_RS06435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS06445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CUB89_RS06450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB89_RS06490	COG0534	Mate efflux family protein
CUB89_RS06495	COG2226	methyltransferase
CUB89_RS06515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CUB89_RS06520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CUB89_RS06525	COG2890	protein-(glutamine-N5) methyltransferase activity
CUB89_RS06530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CUB89_RS06540	COG1115	amino acid carrier protein
CUB89_RS06555	COG2066	Belongs to the glutaminase family
CUB89_RS06560	COG0531	amino acid
CUB89_RS06605	COG0442	prolyl-tRNA aminoacylation
CUB89_RS06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB89_RS06655	COG1971	Probably functions as a manganese efflux pump
CUB89_RS06690	COG0673	inositol 2-dehydrogenase activity
CUB89_RS06720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CUB89_RS06725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CUB89_RS06730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUB89_RS06750	COG0564	pseudouridine synthase activity
CUB89_RS06755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUB89_RS06775	COG1131	(ABC) transporter
CUB89_RS06780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUB89_RS06785	COG0494	nUDIX hydrolase
CUB89_RS06800	COG0653	protein targeting
CUB89_RS06805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUB89_RS06840	COG0018	arginyl-trna synthetase
CUB89_RS06850	COG0339	signal peptide processing
CUB89_RS06880	COG0318	PFAM AMP-dependent synthetase and ligase
CUB89_RS06895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB89_RS06900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB89_RS06910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CUB89_RS06915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUB89_RS06920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS06940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB89_RS06940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB89_RS06950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB89_RS06950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB89_RS06970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUB89_RS06975	COG0778	Nitroreductase
CUB89_RS07005	COG0375	protein maturation
CUB89_RS07020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CUB89_RS07045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUB89_RS07060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUB89_RS07065	COG0193	aminoacyl-tRNA hydrolase activity
CUB89_RS07075	COG0714	Associated with various cellular activities
CUB89_RS07090	COG1063	alcohol dehydrogenase
CUB89_RS07095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUB89_RS07130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUB89_RS07145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CUB89_RS07170	COG0280	phosphate acetyltransferase
CUB89_RS07170	COG0281	malic enzyme
CUB89_RS07175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CUB89_RS07180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB89_RS07180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB89_RS07185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUB89_RS07230	COG1216	Glycosyl transferase, family 2
CUB89_RS07260	COG0438	transferase activity, transferring glycosyl groups
CUB89_RS07275	COG1216	Glycosyl transferase, family 2
CUB89_RS07285	COG1215	transferase activity, transferring glycosyl groups
CUB89_RS07290	COG2244	polysaccharide biosynthetic process
CUB89_RS07300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB89_RS07310	COG0489	protein tyrosine kinase activity
CUB89_RS07330	COG1674	ftsk spoiiie
CUB89_RS07340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUB89_RS07345	COG1592	Rubrerythrin
CUB89_RS07350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUB89_RS07365	COG0753	catalase activity
CUB89_RS07385	COG1012	belongs to the aldehyde dehydrogenase family
CUB89_RS07460	COG0586	Pfam SNARE associated Golgi protein
CUB89_RS07465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB89_RS07475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CUB89_RS07490	COG0038	chloride channel
CUB89_RS07510	COG4112	unkown
CUB89_RS07530	COG1538	Outer membrane efflux protein
CUB89_RS07540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB89_RS07545	COG0339	signal peptide processing
CUB89_RS07550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUB89_RS07565	COG0489	protein tyrosine kinase activity
CUB89_RS07570	COG0534	Mate efflux family protein
CUB89_RS07600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUB89_RS07620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB89_RS07635	COG0418	dihydroorotase activity
CUB89_RS07640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUB89_RS07650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CUB89_RS07670	COG1703	isobutyryl-CoA mutase activity
CUB89_RS07695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CUB89_RS07700	COG0352	thiamine-phosphate diphosphorylase activity
CUB89_RS07715	COG1959	2 iron, 2 sulfur cluster binding
CUB89_RS07720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUB89_RS07735	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CUB89_RS07760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CUB89_RS07765	COG0326	Molecular chaperone. Has ATPase activity
CUB89_RS07800	COG3033	Beta-eliminating lyase
CUB89_RS07820	COG2818	Glycosylase
CUB89_RS07825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CUB89_RS07860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUB89_RS07860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CUB89_RS07870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUB89_RS07890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUB89_RS07890	COG0574	Belongs to the PEP-utilizing enzyme family
CUB89_RS07905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUB89_RS07910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUB89_RS07920	COG5522	Integral membrane protein (intg_mem_TP0381)
CUB89_RS07930	COG0527	aspartate kinase activity
CUB89_RS07935	COG0460	homoserine dehydrogenase
CUB89_RS07945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUB89_RS07950	COG0732	type I restriction modification DNA specificity domain
CUB89_RS07955	COG4974	Belongs to the 'phage' integrase family
CUB89_RS07975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CUB89_RS07980	COG3610	response to peptide
CUB89_RS07985	COG2966	Psort location CytoplasmicMembrane, score
CUB89_RS07990	COG0646	methionine synthase
CUB89_RS07990	COG1410	methionine synthase
CUB89_RS08030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CUB89_RS08035	COG0519	Catalyzes the synthesis of GMP from XMP
CUB89_RS08035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUB89_RS08060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUB89_RS08075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUB89_RS08095	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUB89_RS08100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CUB89_RS08115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB89_RS08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB89_RS08150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUB89_RS08155	COG4605	iron ion homeostasis
CUB89_RS08160	COG4604	ABC transporter, ATP-binding protein
CUB89_RS08165	COG4607	ABC-type enterochelin transport system periplasmic component
CUB89_RS08175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUB89_RS08215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CUB89_RS08220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CUB89_RS08220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUB89_RS08235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUB89_RS08240	COG1454	alcohol dehydrogenase
CUB89_RS08260	COG4974	Belongs to the 'phage' integrase family
CUB89_RS08285	COG1408	metallophosphoesterase
CUB89_RS08295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUB89_RS08315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUB89_RS08325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUB89_RS08345	COG1968	undecaprenyl-diphosphatase activity
CUB89_RS08350	COG0805	protein transport
CUB89_RS08355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB89_RS08355	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CUB89_RS08360	COG0668	transmembrane transport
CUB89_RS08370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUB89_RS08375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUB89_RS08380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CUB89_RS08395	COG0538	isocitrate dehydrogenase activity
CUB89_RS08400	COG3274	enterobacterial common antigen metabolic process
CUB89_RS08410	COG3258	Cytochrome c
CUB89_RS08450	COG0242	peptide deformylase activity
CUB89_RS08460	COG0811	peptide transport
CUB89_RS08475	COG0151	Belongs to the GarS family
CUB89_RS08480	COG3738	Protein conserved in bacteria
CUB89_RS08485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CUB89_RS08490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CUB89_RS08505	COG0601	transmembrane transport
CUB89_RS08510	COG4239	(ABC) transporter, permease
CUB89_RS08515	COG4166	transmembrane transport
CUB89_RS08520	COG0444	Belongs to the ABC transporter superfamily
CUB89_RS08525	COG4608	Belongs to the ABC transporter superfamily
CUB89_RS08530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUB89_RS08540	COG0697	spore germination
CUB89_RS08545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CUB89_RS08550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS08570	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CUB89_RS08590	COG1595	DNA-templated transcription, initiation
CUB89_RS08605	COG0738	Major facilitator superfamily
CUB89_RS08620	COG1070	Carbohydrate kinase
CUB89_RS08655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CUB89_RS08670	COG0363	glucosamine-6-phosphate deaminase activity
CUB89_RS08675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUB89_RS08685	COG1837	Belongs to the UPF0109 family
CUB89_RS08700	COG1091	dTDP-4-dehydrorhamnose reductase activity
CUB89_RS08725	COG0534	Mate efflux family protein
CUB89_RS08745	COG0789	Transcriptional regulator
CUB89_RS08765	COG1408	metallophosphoesterase
CUB89_RS08770	COG0667	Aldo Keto reductase
CUB89_RS08780	COG0656	L-ascorbic acid biosynthetic process
CUB89_RS08790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUB89_RS08810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB89_RS08810	COG2755	lipolytic protein G-D-S-L family
CUB89_RS08820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS08825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB89_RS08865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUB89_RS08870	COG0154	amidase activity
CUB89_RS08875	COG0714	Associated with various cellular activities
CUB89_RS08890	COG2304	oxidoreductase activity
CUB89_RS08905	COG0656	L-ascorbic acid biosynthetic process
CUB89_RS08910	COG0423	glycine-tRNA ligase activity
CUB89_RS08925	COG0436	Aminotransferase
CUB89_RS08930	COG1522	sequence-specific DNA binding
CUB89_RS08945	COG1401	restriction endodeoxyribonuclease activity
CUB89_RS08945	COG1401	restriction endodeoxyribonuclease activity
CUB89_RS08960	COG1215	transferase activity, transferring glycosyl groups
CUB89_RS08975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUB89_RS08990	COG1131	(ABC) transporter
CUB89_RS08995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUB89_RS09000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CUB89_RS09005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUB89_RS09010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUB89_RS09020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CUB89_RS09025	COG2166	iron-sulfur cluster assembly
CUB89_RS09035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CUB89_RS09040	COG3475	LICD family
CUB89_RS09055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUB89_RS09060	COG3475	LICD family
CUB89_RS09070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUB89_RS09075	COG3475	LICD family
CUB89_RS09090	COG4106	trans-aconitate 2-methyltransferase activity
CUB89_RS09120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CUB89_RS09135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CUB89_RS09140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUB89_RS09150	COG0113	porphobilinogen synthase activity
CUB89_RS09165	COG2205	protein histidine kinase activity
CUB89_RS09170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB89_RS09230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CUB89_RS09235	COG0045	succinate-CoA ligase (ADP-forming) activity
CUB89_RS09240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUB89_RS09255	COG0514	ATP-dependent DNA helicase (RecQ)
CUB89_RS09275	COG2949	membrane
CUB89_RS09305	COG1846	Transcriptional regulator
CUB89_RS09325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUB89_RS09335	COG1271	oxidase subunit
CUB89_RS09340	COG1294	oxidase, subunit
CUB89_RS09360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUB89_RS09365	COG0402	S-adenosylhomocysteine deaminase activity
CUB89_RS09385	COG4771	TonB-dependent receptor
CUB89_RS09400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CUB89_RS09405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CUB89_RS09410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CUB89_RS09455	COG0205	6-phosphofructokinase activity
CUB89_RS09475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CUB89_RS09480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUB89_RS09485	COG3250	beta-galactosidase activity
CUB89_RS09490	COG3250	beta-galactosidase activity
CUB89_RS09495	COG3250	beta-galactosidase activity
CUB89_RS09505	COG1166	arginine decarboxylase activity
CUB89_RS09520	COG3119	arylsulfatase activity
CUB89_RS09525	COG0495	leucyl-tRNA aminoacylation
CUB89_RS09530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUB89_RS09535	COG0688	phosphatidylethanolamine metabolic process
CUB89_RS09545	COG0028	Belongs to the TPP enzyme family
CUB89_RS09550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB89_RS09555	COG0268	Binds directly to 16S ribosomal RNA
CUB89_RS09565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CUB89_RS09570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUB89_RS09590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CUB89_RS09605	COG1450	Type ii and iii secretion system protein
CUB89_RS09615	COG0617	tRNA 3'-terminal CCA addition
CUB89_RS09630	COG1643	Atp-dependent helicase
CUB89_RS09645	COG0793	Belongs to the peptidase S41A family
CUB89_RS09650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUB89_RS09665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CUB89_RS09670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUB89_RS09675	COG0358	DNA primase activity
CUB89_RS09680	COG1030	water channel activity
CUB89_RS09685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB89_RS09700	COG1640	4-alpha-glucanotransferase
CUB89_RS09705	COG3210	domain, Protein
CUB89_RS09715	COG2264	protein methyltransferase activity
CUB89_RS09725	COG0307	riboflavin synthase, alpha
CUB89_RS09735	COG0726	polysaccharide deacetylase
CUB89_RS09750	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CUB89_RS09755	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CUB89_RS09760	COG1034	ATP synthesis coupled electron transport
CUB89_RS09765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CUB89_RS09775	COG0839	Belongs to the complex I subunit 6 family
CUB89_RS09780	COG0713	ATP synthesis coupled electron transport
CUB89_RS09795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB89_RS09800	COG1007	ATP synthesis coupled electron transport
CUB89_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
CUB89_RS09830	COG0142	geranyltranstransferase activity
CUB89_RS09835	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CUB89_RS09840	COG0037	tRNA processing
CUB89_RS09845	COG1691	(AIR) carboxylase
CUB89_RS09850	COG1649	PFAM Uncharacterised BCR, COG1649
CUB89_RS09860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CUB89_RS09860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUB89_RS09865	COG0728	peptidoglycan biosynthetic process
CUB89_RS09880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUB89_RS09885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUB89_RS09890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUB89_RS09895	COG1459	type II secretion system
CUB89_RS09905	COG0463	Glycosyl transferase, family 2
CUB89_RS09910	COG1215	transferase activity, transferring glycosyl groups
CUB89_RS09915	COG0105	UTP biosynthetic process
CUB89_RS09925	COG1187	pseudouridine synthase activity
CUB89_RS09935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CUB89_RS09950	COG0372	Belongs to the citrate synthase family
CUB89_RS09975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUB89_RS09990	COG1979	alcohol dehydrogenase
CUB89_RS09995	COG2373	Large extracellular alpha-helical protein
CUB89_RS10000	COG0697	spore germination
CUB89_RS10010	COG1074	ATP-dependent DNA helicase activity
CUB89_RS10030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUB89_RS10035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CUB89_RS10040	COG0556	nucleotide-excision repair
CUB89_RS10055	COG2223	nitrite transmembrane transporter activity
CUB89_RS10060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB89_RS10065	COG0561	phosphatase activity
CUB89_RS10090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CUB89_RS10100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CUB89_RS10105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CUB89_RS10130	COG0159	tryptophan synthase activity
CUB89_RS10140	COG0135	phosphoribosylanthranilate isomerase activity
CUB89_RS10145	COG0134	indole-3-glycerol-phosphate synthase activity
CUB89_RS10150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUB89_RS10155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUB89_RS10170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CUB89_RS10175	COG0667	Aldo Keto reductase
CUB89_RS10235	COG2885	chlorophyll binding
CUB89_RS10250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB89_RS10260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CUB89_RS10265	COG0203	ribosomal protein L17
CUB89_RS10270	COG0202	RNA polymerase activity
CUB89_RS10290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB89_RS10290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB89_RS10330	COG1575	Belongs to the MenA family. Type 1 subfamily
CUB89_RS10345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB89_RS10350	COG3273	potassium ion transport
CUB89_RS10350	COG0471	metal ion transport
CUB89_RS10360	COG1561	YicC-like family, N-terminal region
CUB89_RS10365	COG3977	Valine--pyruvate aminotransferase
CUB89_RS10380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB89_RS10385	COG0428	transporter
CUB89_RS10395	COG0205	6-phosphofructokinase activity
CUB89_RS10400	COG1686	Belongs to the peptidase S11 family
CUB89_RS10415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CUB89_RS10420	COG0360	Binds together with S18 to 16S ribosomal RNA
CUB89_RS10425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CUB89_RS10430	COG0131	Imidazoleglycerol-phosphate dehydratase
CUB89_RS10440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUB89_RS10445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUB89_RS10470	COG0277	FAD linked oxidase domain protein
CUB89_RS10485	COG5434	Belongs to the glycosyl hydrolase 28 family
CUB89_RS10495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CUB89_RS10500	COG0484	heat shock protein binding
CUB89_RS10505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CUB89_RS10510	COG1872	DUF167
CUB89_RS10515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CUB89_RS10535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUB89_RS10555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CUB89_RS10560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CUB89_RS10570	COG0765	amino acid transport
CUB89_RS10575	COG1126	abc transporter atp-binding protein
CUB89_RS10600	COG0564	pseudouridine synthase activity
CUB89_RS10605	COG0778	Nitroreductase
CUB89_RS10630	COG0039	L-malate dehydrogenase activity
CUB89_RS10635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CUB89_RS10670	COG0254	rRNA binding
CUB89_RS10675	COG0037	tRNA processing
CUB89_RS10685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CUB89_RS10700	COG2271	Major facilitator Superfamily
CUB89_RS10710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUB89_RS10720	COG0515	serine threonine protein kinase
CUB89_RS10720	COG2815	serine threonine protein kinase
CUB89_RS10725	COG1082	Xylose isomerase domain protein TIM barrel
CUB89_RS10735	COG0126	phosphoglycerate kinase activity
CUB89_RS10745	COG0632	four-way junction helicase activity
CUB89_RS10800	COG0459	protein refolding
CUB89_RS10805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CUB89_RS10810	COG0443	Heat shock 70 kDa protein
CUB89_RS10815	COG0438	transferase activity, transferring glycosyl groups
CUB89_RS10840	COG0298	carbon dioxide binding
CUB89_RS10845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CUB89_RS10855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CUB89_RS10860	COG0124	histidyl-tRNA synthetase
CUB89_RS10865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUB89_RS10890	COG0156	8-amino-7-oxononanoate synthase activity
CUB89_RS10915	COG1028	Short-chain dehydrogenase reductase Sdr
CUB89_RS10920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CUB89_RS10930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CUB89_RS10940	COG1183	phosphatidylcholine synthase activity
CUB89_RS10945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUB89_RS10955	COG1131	(ABC) transporter
CUB89_RS10960	COG0842	Transport permease protein
CUB89_RS10965	COG0842	Transport permease protein
CUB89_RS11015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CUB89_RS11020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUB89_RS11025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CUB89_RS11035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CUB89_RS11050	COG0733	neurotransmitter:sodium symporter activity
CUB89_RS11055	COG0450	alkyl hydroperoxide reductase
CUB89_RS11060	COG0668	transmembrane transport
CUB89_RS11065	COG0528	UMP kinase activity
CUB89_RS11070	COG0233	cytoplasmic translational termination
CUB89_RS11110	COG0612	Peptidase, M16
CUB89_RS11125	COG2017	converts alpha-aldose to the beta-anomer
CUB89_RS11135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CUB89_RS11145	COG0573	inorganic phosphate transmembrane transporter activity
CUB89_RS11150	COG0581	inorganic phosphate transmembrane transporter activity
CUB89_RS11170	COG0175	sulfate reduction
CUB89_RS11175	COG0175	sulfate reduction
CUB89_RS11180	COG2895	sulfate adenylyltransferase (ATP) activity
CUB89_RS11180	COG0529	Catalyzes the synthesis of activated sulfate
CUB89_RS11200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CUB89_RS11220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUB89_RS11225	COG0826	peptidase U32
CUB89_RS11235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CUB89_RS11255	COG0545	Peptidyl-prolyl cis-trans isomerase
CUB89_RS11260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CUB89_RS11270	COG1408	metallophosphoesterase
CUB89_RS11320	COG3118	belongs to the thioredoxin family
CUB89_RS11320	COG0492	ferredoxin-NADP+ reductase activity
CUB89_RS11325	COG1760	l-serine dehydratase
CUB89_RS11340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CUB89_RS11355	COG0259	pyridoxamine-phosphate oxidase activity
CUB89_RS11360	COG0676	glucose-6-phosphate 1-epimerase activity
CUB89_RS11370	COG0657	acetylesterase activity
CUB89_RS11370	COG2755	lipolytic protein G-D-S-L family
CUB89_RS11385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CUB89_RS11395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUB89_RS11400	COG0706	membrane insertase activity
CUB89_RS11410	COG0069	glutamate synthase activity
CUB89_RS11410	COG0067	glutamate synthase
CUB89_RS11410	COG0070	glutamate synthase
CUB89_RS11420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUB89_RS11425	COG0505	Belongs to the CarA family
CUB89_RS11430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CUB89_RS11435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB89_RS11440	COG1757	Na H antiporter
CUB89_RS11450	COG1482	cell wall glycoprotein biosynthetic process
CUB89_RS11460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUB89_RS11465	COG0483	inositol monophosphate 1-phosphatase activity
CUB89_RS11470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CUB89_RS11480	COG0848	biopolymer transport protein
CUB89_RS11485	COG0811	peptide transport
CUB89_RS11490	COG0322	excinuclease ABC activity
CUB89_RS11495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUB89_RS11500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUB89_RS11505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUB89_RS11510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUB89_RS11515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUB89_RS11515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CUB89_RS11520	COG2003	Belongs to the UPF0758 family
CUB89_RS11540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CUB89_RS11545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CUB89_RS11565	COG0284	orotidine-5'-phosphate decarboxylase activity
CUB89_RS11620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUB89_RS11645	COG0437	4 iron, 4 sulfur cluster binding
CUB89_RS11655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CUB89_RS11660	COG3409	Peptidoglycan-binding domain 1 protein
CUB89_RS11660	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUB89_RS11675	COG0736	holo-[acyl-carrier-protein] synthase activity
CUB89_RS11680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CUB89_RS11685	COG0138	bifunctional purine biosynthesis protein purh
CUB89_RS11690	COG0359	binds to the 23S rRNA
CUB89_RS11695	COG0598	Magnesium transport protein CorA
CUB89_RS11700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CUB89_RS11725	COG1122	ATPase activity
CUB89_RS11730	COG1199	ATP-dependent helicase activity
CUB89_RS11740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CUB89_RS11760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUB89_RS11770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUB89_RS11785	COG1477	protein flavinylation
CUB89_RS11790	COG0436	Aminotransferase
CUB89_RS11800	COG0148	phosphopyruvate hydratase activity
CUB89_RS11825	COG2186	Transcriptional regulator
CUB89_RS11830	COG1119	ATPase activity
CUB89_RS11835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CUB89_RS11850	COG1090	epimerase
CUB89_RS11875	COG2311	Membrane
CUB89_RS11880	COG0714	Associated with various cellular activities
CUB89_RS11930	COG0789	Transcriptional regulator
CUB89_RS11935	COG0667	Aldo Keto reductase
CUB89_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUB89_RS11960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUB89_RS11970	COG2205	protein histidine kinase activity
CUB89_RS11975	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CUB89_RS11980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CUB89_RS11985	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CUB89_RS12055	COG3209	COG3209 Rhs family protein