locus-tag	class	description
C1O37_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1O37_RS00010	COG1131	(ABC) transporter
C1O37_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1O37_RS00035	COG0564	pseudouridine synthase activity
C1O37_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1O37_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1O37_RS00065	COG0513	Belongs to the DEAD box helicase family
C1O37_RS00075	COG0673	inositol 2-dehydrogenase activity
C1O37_RS00110	COG1971	Probably functions as a manganese efflux pump
C1O37_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O37_RS00160	COG0442	prolyl-tRNA aminoacylation
C1O37_RS00175	COG2963	transposase activity
C1O37_RS00210	COG0531	amino acid
C1O37_RS00215	COG2066	Belongs to the glutaminase family
C1O37_RS00225	COG1115	amino acid carrier protein
C1O37_RS00235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1O37_RS00240	COG2890	protein-(glutamine-N5) methyltransferase activity
C1O37_RS00245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1O37_RS00250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1O37_RS00265	COG2226	methyltransferase
C1O37_RS00270	COG0534	Mate efflux family protein
C1O37_RS00310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1O37_RS00315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS00330	COG1121	(ABC) transporter
C1O37_RS00335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1O37_RS00340	COG3880	PFAM UvrB UvrC protein
C1O37_RS00345	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C1O37_RS00350	COG0542	response to heat
C1O37_RS00360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O37_RS00365	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O37_RS00370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O37_RS00385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O37_RS00385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1O37_RS00395	COG0180	Tryptophanyl-tRNA synthetase
C1O37_RS00405	COG1692	metallophosphoesterase
C1O37_RS00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1O37_RS00470	COG0515	serine threonine protein kinase
C1O37_RS00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O37_RS00560	COG2816	NAD+ diphosphatase activity
C1O37_RS00565	COG0156	8-amino-7-oxononanoate synthase activity
C1O37_RS00580	COG0515	serine threonine protein kinase
C1O37_RS00580	COG3266	domain, Protein
C1O37_RS00620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1O37_RS00630	COG3189	MarR family transcriptional regulator
C1O37_RS00635	COG0181	hydroxymethylbilane synthase activity
C1O37_RS00640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1O37_RS00650	COG1469	GTP cyclohydrolase I activity
C1O37_RS00655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1O37_RS00660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1O37_RS00665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O37_RS00670	COG1940	carbohydrate kinase activity
C1O37_RS00685	COG0494	nUDIX hydrolase
C1O37_RS00690	COG1566	PFAM secretion protein HlyD family protein
C1O37_RS00695	COG1136	(ABC) transporter
C1O37_RS00695	COG0577	efflux transmembrane transporter activity
C1O37_RS00700	COG1136	(ABC) transporter
C1O37_RS00700	COG0577	efflux transmembrane transporter activity
C1O37_RS00705	COG1538	Outer membrane efflux protein
C1O37_RS00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O37_RS00760	COG1720	tRNA m6t6A37 methyltransferase activity
C1O37_RS00765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1O37_RS00770	COG0540	Belongs to the ATCase OTCase family
C1O37_RS00775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1O37_RS00790	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1O37_RS00795	COG2957	Belongs to the agmatine deiminase family
C1O37_RS00805	COG0750	zinc metalloprotease
C1O37_RS00815	COG3119	arylsulfatase activity
C1O37_RS00825	COG1918	ferrous iron import across plasma membrane
C1O37_RS00825	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1O37_RS00875	COG1475	DNA binding
C1O37_RS00910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1O37_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O37_RS00930	COG0601	transmembrane transport
C1O37_RS00980	COG0849	cell division
C1O37_RS00990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1O37_RS00995	COG1132	(ABC) transporter
C1O37_RS01000	COG1132	(ABC) transporter
C1O37_RS01015	COG1127	ABC transporter
C1O37_RS01020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1O37_RS01050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O37_RS01065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1O37_RS01070	COG0504	CTP synthase activity
C1O37_RS01075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1O37_RS01100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS01110	COG1322	Protein conserved in bacteria
C1O37_RS01115	COG0546	phosphoglycolate phosphatase activity
C1O37_RS01120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O37_RS01130	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O37_RS01130	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O37_RS01145	COG3209	COG3209 Rhs family protein
C1O37_RS01150	COG4104	PAAR repeat-containing protein
C1O37_RS01150	COG3209	COG3209 Rhs family protein
C1O37_RS01170	COG3209	COG3209 Rhs family protein
C1O37_RS01210	COG2234	aminopeptidase activity
C1O37_RS01215	COG0657	acetylesterase activity
C1O37_RS01215	COG2755	lipolytic protein G-D-S-L family
C1O37_RS01220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1O37_RS01240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1O37_RS01260	COG0335	large ribosomal subunit rRNA binding
C1O37_RS01270	COG0346	lactoylglutathione lyase activity
C1O37_RS01285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1O37_RS01290	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1O37_RS01300	COG0427	acetyl-CoA hydrolase
C1O37_RS01315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1O37_RS01325	COG0205	6-phosphofructokinase activity
C1O37_RS01335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1O37_RS01340	COG0028	Belongs to the TPP enzyme family
C1O37_RS01360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1O37_RS01375	COG0471	metal ion transport
C1O37_RS01385	COG0351	phosphomethylpyrimidine kinase
C1O37_RS01445	COG0242	peptide deformylase activity
C1O37_RS01450	COG1063	alcohol dehydrogenase
C1O37_RS01460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1O37_RS01465	COG1393	Belongs to the ArsC family
C1O37_RS01470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O37_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1O37_RS01490	COG1187	pseudouridine synthase activity
C1O37_RS01500	COG0336	Belongs to the RNA methyltransferase TrmD family
C1O37_RS01505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1O37_RS01515	COG0539	negative regulation of cytoplasmic translation
C1O37_RS01560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1O37_RS01565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1O37_RS01570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1O37_RS01575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O37_RS01610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O37_RS01685	COG3015	lipoprotein NlpE involved in copper resistance
C1O37_RS01755	COG0305	Participates in initiation and elongation during chromosome replication
C1O37_RS01855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1O37_RS01855	COG0662	Cupin 2, conserved barrel domain protein
C1O37_RS01865	COG0416	fatty acid biosynthetic process
C1O37_RS01870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1O37_RS01880	COG0537	adenosine 5'-monophosphoramidase activity
C1O37_RS01885	COG0009	L-threonylcarbamoyladenylate synthase
C1O37_RS01890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1O37_RS01895	COG0228	four-way junction DNA binding
C1O37_RS01925	COG1862	Preprotein translocase
C1O37_RS01930	COG0343	queuine tRNA-ribosyltransferase activity
C1O37_RS01935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1O37_RS01945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1O37_RS01950	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1O37_RS01955	COG0776	regulation of translation
C1O37_RS01985	COG0811	peptide transport
C1O37_RS02000	COG3250	beta-galactosidase activity
C1O37_RS02005	COG0525	valine-tRNA ligase activity
C1O37_RS02015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1O37_RS02020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1O37_RS02025	COG0255	Belongs to the universal ribosomal protein uL29 family
C1O37_RS02030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1O37_RS02035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1O37_RS02040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1O37_RS02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1O37_RS02055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1O37_RS02060	COG0089	rRNA binding
C1O37_RS02065	COG0088	Forms part of the polypeptide exit tunnel
C1O37_RS02070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1O37_RS02075	COG0051	transcription antitermination factor activity, RNA binding
C1O37_RS02080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1O37_RS02085	COG0049	tRNA binding
C1O37_RS02090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1O37_RS02095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1O37_RS02105	COG3852	Histidine kinase
C1O37_RS02110	COG2204	response regulator
C1O37_RS02120	COG1722	exodeoxyribonuclease VII activity
C1O37_RS02125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O37_RS02140	COG0795	lipopolysaccharide-transporting ATPase activity
C1O37_RS02145	COG1160	GTP binding
C1O37_RS02150	COG0444	Belongs to the ABC transporter superfamily
C1O37_RS02165	COG1136	(ABC) transporter
C1O37_RS02165	COG0577	efflux transmembrane transporter activity
C1O37_RS02175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O37_RS02220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1O37_RS02225	COG0799	negative regulation of ribosome biogenesis
C1O37_RS02230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1O37_RS02280	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1O37_RS02295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1O37_RS02305	COG4221	oxidoreductase activity
C1O37_RS02325	COG0038	chloride channel
C1O37_RS02335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS02350	COG0076	glutamate decarboxylase activity
C1O37_RS02365	COG0167	dihydroorotate dehydrogenase activity
C1O37_RS02370	COG0352	thiamine-phosphate diphosphorylase activity
C1O37_RS02390	COG1253	flavin adenine dinucleotide binding
C1O37_RS02395	COG1253	flavin adenine dinucleotide binding
C1O37_RS02400	COG1185	polyribonucleotide nucleotidyltransferase activity
C1O37_RS02405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1O37_RS02435	COG0101	tRNA pseudouridine synthase activity
C1O37_RS02440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1O37_RS02455	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1O37_RS02470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS02475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1O37_RS02490	COG1136	(ABC) transporter
C1O37_RS02495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1O37_RS02505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O37_RS02515	COG1116	anion transmembrane transporter activity
C1O37_RS02530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS02535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1O37_RS02540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O37_RS02550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1O37_RS02555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1O37_RS02565	COG2814	Major facilitator Superfamily
C1O37_RS02575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O37_RS02580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O37_RS02580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O37_RS02585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1O37_RS02590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1O37_RS02595	COG0552	protein localization to endoplasmic reticulum
C1O37_RS02600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1O37_RS02620	COG1546	Belongs to the CinA family
C1O37_RS02620	COG1058	Belongs to the CinA family
C1O37_RS02630	COG0456	acetyltransferase
C1O37_RS02655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1O37_RS02660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1O37_RS02665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1O37_RS02670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O37_RS02685	COG0758	DNA mediated transformation
C1O37_RS02690	COG1686	Belongs to the peptidase S11 family
C1O37_RS02695	COG0012	GTP binding
C1O37_RS02700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1O37_RS02710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O37_RS02710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O37_RS02725	COG3119	arylsulfatase activity
C1O37_RS02750	COG2259	Doxx family
C1O37_RS02755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1O37_RS02785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O37_RS02805	COG2326	polyphosphate kinase activity
C1O37_RS02810	COG1349	DNA-binding transcription factor activity
C1O37_RS02830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O37_RS02835	COG1162	GTPase activity
C1O37_RS02850	COG0742	ribosomal rna small subunit methyltransferase
C1O37_RS02865	COG2326	polyphosphate kinase activity
C1O37_RS02875	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O37_RS02885	COG1073	alpha beta
C1O37_RS02890	COG0802	atpase or kinase
C1O37_RS02895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1O37_RS02900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1O37_RS02905	COG0735	belongs to the Fur family
C1O37_RS02910	COG0396	ATPase activity
C1O37_RS02915	COG0719	Fe-S assembly protein
C1O37_RS02920	COG0719	Fe-S assembly protein
C1O37_RS02935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1O37_RS02980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1O37_RS03000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1O37_RS03005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1O37_RS03010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1O37_RS03015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1O37_RS03020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1O37_RS03025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1O37_RS03035	COG0356	it plays a direct role in the translocation of protons across the membrane
C1O37_RS03085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1O37_RS03120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1O37_RS03125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1O37_RS03130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1O37_RS03140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1O37_RS03150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1O37_RS03155	COG0047	phosphoribosylformylglycinamidine synthase activity
C1O37_RS03165	COG1363	Peptidase, m42
C1O37_RS03180	COG1077	Cell shape determining protein MreB Mrl
C1O37_RS03185	COG1530	ribonuclease E activity
C1O37_RS03205	COG0848	biopolymer transport protein
C1O37_RS03220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1O37_RS03235	COG0134	indole-3-glycerol-phosphate synthase activity
C1O37_RS03240	COG0792	nuclease activity
C1O37_RS03250	COG1253	flavin adenine dinucleotide binding
C1O37_RS03260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1O37_RS03265	COG0137	argininosuccinate synthase activity
C1O37_RS03280	COG0149	triose-phosphate isomerase activity
C1O37_RS03315	COG1040	competence protein
C1O37_RS03325	COG3956	TIGRFAM MazG family protein
C1O37_RS03345	COG1663	tetraacyldisaccharide 4'-kinase activity
C1O37_RS03355	COG0612	Peptidase, M16
C1O37_RS03370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O37_RS03400	COG0673	inositol 2-dehydrogenase activity
C1O37_RS03405	COG3034	peptidoglycan biosynthetic process
C1O37_RS03425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1O37_RS03430	COG0424	maF-like protein
C1O37_RS03435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1O37_RS03465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1O37_RS03475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1O37_RS03485	COG0571	ribonuclease III activity
C1O37_RS03505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1O37_RS03520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1O37_RS03540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O37_RS03550	COG2226	methyltransferase
C1O37_RS03560	COG2076	Multidrug Resistance protein
C1O37_RS03630	COG2255	four-way junction helicase activity
C1O37_RS03635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O37_RS03640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O37_RS03645	COG1215	transferase activity, transferring glycosyl groups
C1O37_RS03650	COG1216	Glycosyl transferase, family 2
C1O37_RS03650	COG0463	Glycosyl transferase, family 2
C1O37_RS03675	COG0438	transferase activity, transferring glycosyl groups
C1O37_RS03685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O37_RS03695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1O37_RS03705	COG0482	sulfurtransferase activity
C1O37_RS03710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1O37_RS03720	COG2860	membrane
C1O37_RS03725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O37_RS03730	COG2001	Belongs to the MraZ family
C1O37_RS03735	COG0275	rRNA processing
C1O37_RS03745	COG0768	penicillin binding
C1O37_RS03750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1O37_RS03755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1O37_RS03760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1O37_RS03765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1O37_RS03775	COG0772	Belongs to the SEDS family
C1O37_RS03780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1O37_RS03785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O37_RS03790	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1O37_RS03800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1O37_RS03805	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1O37_RS03810	COG0321	lipoyl(octanoyl) transferase activity
C1O37_RS03815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1O37_RS03820	COG0066	3-isopropylmalate dehydratase activity
C1O37_RS03830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS03840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O37_RS03845	COG4608	Belongs to the ABC transporter superfamily
C1O37_RS03855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1O37_RS03860	COG0052	Belongs to the universal ribosomal protein uS2 family
C1O37_RS03870	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1O37_RS03885	COG1137	ATPase activity
C1O37_RS03895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O37_RS03920	COG0017	Asparaginyl-tRNA synthetase
C1O37_RS03930	COG3118	belongs to the thioredoxin family
C1O37_RS03975	COG0583	DNA-binding transcription factor activity
C1O37_RS03980	COG2855	membrane
C1O37_RS03985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1O37_RS03995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O37_RS04005	COG0602	queuosine metabolic process
C1O37_RS04010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O37_RS04015	COG0217	transcriptional regulatory protein
C1O37_RS04020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1O37_RS04025	COG4651	solute:proton antiporter activity
C1O37_RS04025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O37_RS04035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1O37_RS04040	COG4864	UPF0365 protein
C1O37_RS04050	COG2022	thiamine diphosphate biosynthetic process
C1O37_RS04055	COG0531	amino acid
C1O37_RS04065	COG0628	permease
C1O37_RS04070	COG0019	diaminopimelate decarboxylase activity
C1O37_RS04080	COG1217	gtp-binding protein TYPA
C1O37_RS04110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1O37_RS04160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O37_RS04165	COG0516	GMP reductase activity
C1O37_RS04165	COG0517	IMP dehydrogenase activity
C1O37_RS04170	COG0519	Catalyzes the synthesis of GMP from XMP
C1O37_RS04170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1O37_RS04195	COG0546	phosphoglycolate phosphatase activity
C1O37_RS04220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O37_RS04235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1O37_RS04240	COG0196	riboflavin kinase activity
C1O37_RS04245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1O37_RS04255	COG1408	metallophosphoesterase
C1O37_RS04265	COG1442	glycosyl transferase family 8
C1O37_RS04265	COG1216	Glycosyl transferase, family 2
C1O37_RS04275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O37_RS04280	COG1216	Glycosyl transferase, family 2
C1O37_RS04300	COG2755	lipolytic protein G-D-S-L family
C1O37_RS04300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O37_RS04315	COG0471	metal ion transport
C1O37_RS04315	COG0490	domain, Protein
C1O37_RS04350	COG0588	phosphoglycerate mutase activity
C1O37_RS04355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1O37_RS04365	COG0477	Major facilitator Superfamily
C1O37_RS04370	COG1607	acyl-coa hydrolase
C1O37_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
C1O37_RS04390	COG1525	nuclease
C1O37_RS04400	COG1475	DNA binding
C1O37_RS04405	COG3969	phosphoadenosine phosphosulfate
C1O37_RS04415	COG0473	3-isopropylmalate dehydrogenase activity
C1O37_RS04440	COG2873	o-acetylhomoserine
C1O37_RS04445	COG0535	radical SAM domain protein
C1O37_RS04450	COG0535	radical SAM domain protein
C1O37_RS04465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O37_RS04470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1O37_RS04480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1O37_RS04485	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1O37_RS04485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1O37_RS04485	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1O37_RS04485	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1O37_RS04495	COG1733	regulation of RNA biosynthetic process
C1O37_RS04505	COG0107	imidazoleglycerol-phosphate synthase activity
C1O37_RS04510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O37_RS04520	COG1643	Atp-dependent helicase
C1O37_RS04525	COG0440	acetolactate synthase activity
C1O37_RS04530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS04540	COG0445	tRNA wobble uridine modification
C1O37_RS04545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O37_RS04545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O37_RS04550	COG0592	DNA-directed DNA polymerase activity
C1O37_RS04575	COG1388	LysM domain
C1O37_RS04575	COG0791	NLP P60 protein
C1O37_RS04580	COG0084	hydrolase, TatD family'
C1O37_RS04590	COG3250	beta-galactosidase activity
C1O37_RS04605	COG2205	protein histidine kinase activity
C1O37_RS04610	COG0745	RESPONSE REGULATOR receiver
C1O37_RS04620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O37_RS04645	COG0542	response to heat
C1O37_RS04690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1O37_RS04700	COG0659	secondary active sulfate transmembrane transporter activity
C1O37_RS04705	COG0165	Argininosuccinate lyase
C1O37_RS04720	COG0148	phosphopyruvate hydratase activity
C1O37_RS04725	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1O37_RS04735	COG3481	metal-dependent phosphohydrolase, HD sub domain
C1O37_RS04745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O37_RS04750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O37_RS04815	COG0490	domain, Protein
C1O37_RS04815	COG2985	domain, Protein
C1O37_RS04830	COG0471	metal ion transport
C1O37_RS04855	COG2194	sulfuric ester hydrolase activity
C1O37_RS04860	COG1592	Rubrerythrin
C1O37_RS04870	COG1363	Peptidase, m42
C1O37_RS04875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS04885	COG1785	Belongs to the alkaline phosphatase family
C1O37_RS04890	COG1970	mechanosensitive ion channel activity
C1O37_RS04895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1O37_RS04905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1O37_RS04915	COG2217	Heavy metal translocating P-type atpase
C1O37_RS04920	COG0497	DNA recombination
C1O37_RS04925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1O37_RS04925	COG0321	lipoyl(octanoyl) transferase activity
C1O37_RS04930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C1O37_RS04955	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O37_RS04960	COG0022	dehydrogenase e1 component
C1O37_RS04965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O37_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O37_RS04980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O37_RS04985	COG3210	domain, Protein
C1O37_RS05035	COG3409	Peptidoglycan-binding domain 1 protein
C1O37_RS05035	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O37_RS05040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1O37_RS05065	COG1690	Belongs to the RtcB family
C1O37_RS05075	COG2814	Major facilitator Superfamily
C1O37_RS05085	COG2096	Adenosyltransferase
C1O37_RS05095	COG0557	exoribonuclease II activity
C1O37_RS05120	COG0826	peptidase U32
C1O37_RS05125	COG0285	dihydrofolate synthase activity
C1O37_RS05140	COG0673	inositol 2-dehydrogenase activity
C1O37_RS05145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1O37_RS05150	COG0737	Belongs to the 5'-nucleotidase family
C1O37_RS05160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1O37_RS05165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1O37_RS05180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1O37_RS05185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1O37_RS05190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1O37_RS05195	COG0200	Binds to the 23S rRNA
C1O37_RS05200	COG0201	protein transport
C1O37_RS05205	COG0563	adenylate kinase activity
C1O37_RS05210	COG0024	Methionine aminopeptidase
C1O37_RS05225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1O37_RS05230	COG1442	glycosyl transferase family 8
C1O37_RS05240	COG1216	Glycosyl transferase, family 2
C1O37_RS05250	COG1216	Glycosyl transferase, family 2
C1O37_RS05265	COG1216	Glycosyl transferase, family 2
C1O37_RS05270	COG0693	protein deglycase activity
C1O37_RS05275	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O37_RS05280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1O37_RS05285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O37_RS05295	COG1966	Carbon starvation protein
C1O37_RS05305	COG3119	arylsulfatase activity
C1O37_RS05310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1O37_RS05315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1O37_RS05320	COG0195	Participates in both transcription termination and antitermination
C1O37_RS05325	COG0708	Exodeoxyribonuclease III
C1O37_RS05330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1O37_RS05335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C1O37_RS05340	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O37_RS05350	COG1716	ATPase activity
C1O37_RS05350	COG1131	(ABC) transporter
C1O37_RS05350	COG0842	Transport permease protein
C1O37_RS05370	COG0724	RNA recognition motif
C1O37_RS05375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O37_RS05395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1O37_RS05405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1O37_RS05410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1O37_RS05425	COG1490	D-aminoacyl-tRNA deacylase activity
C1O37_RS05440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1O37_RS05445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1O37_RS05450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS05470	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O37_RS05490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O37_RS05490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O37_RS05505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O37_RS05520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O37_RS05525	COG0778	Nitroreductase
C1O37_RS05550	COG0375	protein maturation
C1O37_RS05565	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1O37_RS05590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1O37_RS05605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1O37_RS05610	COG0193	aminoacyl-tRNA hydrolase activity
C1O37_RS05620	COG0714	Associated with various cellular activities
C1O37_RS05635	COG1063	alcohol dehydrogenase
C1O37_RS05640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1O37_RS05675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1O37_RS05690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1O37_RS05695	COG1472	Belongs to the glycosyl hydrolase 3 family
C1O37_RS05710	COG0280	phosphate acetyltransferase
C1O37_RS05710	COG0281	malic enzyme
C1O37_RS05715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1O37_RS05720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O37_RS05725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O37_RS05745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O37_RS05745	COG2755	lipolytic protein G-D-S-L family
C1O37_RS05770	COG1216	Glycosyl transferase, family 2
C1O37_RS05800	COG0438	transferase activity, transferring glycosyl groups
C1O37_RS05815	COG1216	Glycosyl transferase, family 2
C1O37_RS05825	COG1215	transferase activity, transferring glycosyl groups
C1O37_RS05830	COG2244	polysaccharide biosynthetic process
C1O37_RS05840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O37_RS05850	COG0489	protein tyrosine kinase activity
C1O37_RS05880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O37_RS05885	COG1592	Rubrerythrin
C1O37_RS05890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O37_RS05900	COG0753	catalase activity
C1O37_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
C1O37_RS05950	COG1518	maintenance of DNA repeat elements
C1O37_RS06015	COG0586	Pfam SNARE associated Golgi protein
C1O37_RS06020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O37_RS06025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1O37_RS06035	COG0038	chloride channel
C1O37_RS06050	COG4112	unkown
C1O37_RS06065	COG1538	Outer membrane efflux protein
C1O37_RS06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O37_RS06090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O37_RS06100	COG0489	protein tyrosine kinase activity
C1O37_RS06105	COG0534	Mate efflux family protein
C1O37_RS06120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O37_RS06140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O37_RS06155	COG0418	dihydroorotase activity
C1O37_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O37_RS06170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1O37_RS06190	COG1703	isobutyryl-CoA mutase activity
C1O37_RS06200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS06215	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1O37_RS06220	COG0352	thiamine-phosphate diphosphorylase activity
C1O37_RS06235	COG1959	2 iron, 2 sulfur cluster binding
C1O37_RS06240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O37_RS06265	COG0326	Molecular chaperone. Has ATPase activity
C1O37_RS06285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O37_RS06285	COG0072	phenylalanine-tRNA ligase activity
C1O37_RS06300	COG3033	Beta-eliminating lyase
C1O37_RS06320	COG2818	Glycosylase
C1O37_RS06325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1O37_RS06360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O37_RS06360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1O37_RS06370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O37_RS06385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O37_RS06385	COG0574	Belongs to the PEP-utilizing enzyme family
C1O37_RS06390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1O37_RS06400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1O37_RS06405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1O37_RS06415	COG5522	Integral membrane protein (intg_mem_TP0381)
C1O37_RS06425	COG0527	aspartate kinase activity
C1O37_RS06430	COG0460	homoserine dehydrogenase
C1O37_RS06440	COG3610	response to peptide
C1O37_RS06445	COG2966	Psort location CytoplasmicMembrane, score
C1O37_RS06450	COG0646	methionine synthase
C1O37_RS06450	COG1410	methionine synthase
C1O37_RS06485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1O37_RS06510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O37_RS06525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O37_RS06545	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O37_RS06550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1O37_RS06565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O37_RS06565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O37_RS06600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O37_RS06605	COG4605	iron ion homeostasis
C1O37_RS06610	COG4604	ABC transporter, ATP-binding protein
C1O37_RS06615	COG4607	ABC-type enterochelin transport system periplasmic component
C1O37_RS06625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1O37_RS06665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1O37_RS06670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1O37_RS06670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1O37_RS06680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1O37_RS06685	COG1454	alcohol dehydrogenase
C1O37_RS06705	COG4974	Belongs to the 'phage' integrase family
C1O37_RS06730	COG1408	metallophosphoesterase
C1O37_RS06740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O37_RS06750	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1O37_RS06760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1O37_RS06775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1O37_RS06795	COG1968	undecaprenyl-diphosphatase activity
C1O37_RS06800	COG0805	protein transport
C1O37_RS06805	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1O37_RS06805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O37_RS06810	COG0668	transmembrane transport
C1O37_RS06820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1O37_RS06825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1O37_RS06830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1O37_RS06845	COG0538	isocitrate dehydrogenase activity
C1O37_RS06850	COG3274	enterobacterial common antigen metabolic process
C1O37_RS06865	COG3258	Cytochrome c
C1O37_RS06910	COG0242	peptide deformylase activity
C1O37_RS06920	COG0811	peptide transport
C1O37_RS06935	COG0151	Belongs to the GarS family
C1O37_RS06940	COG3738	Protein conserved in bacteria
C1O37_RS06945	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1O37_RS06950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1O37_RS06965	COG0601	transmembrane transport
C1O37_RS06970	COG4239	(ABC) transporter, permease
C1O37_RS06975	COG4166	transmembrane transport
C1O37_RS06980	COG0444	Belongs to the ABC transporter superfamily
C1O37_RS06985	COG4608	Belongs to the ABC transporter superfamily
C1O37_RS06990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O37_RS07000	COG3586	endonuclease activity
C1O37_RS07005	COG0697	spore germination
C1O37_RS07010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1O37_RS07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS07035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1O37_RS07050	COG1595	DNA-templated transcription, initiation
C1O37_RS07065	COG0738	Major facilitator superfamily
C1O37_RS07080	COG1070	Carbohydrate kinase
C1O37_RS07095	COG1741	Belongs to the pirin family
C1O37_RS07105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C1O37_RS07120	COG0363	glucosamine-6-phosphate deaminase activity
C1O37_RS07125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O37_RS07130	COG1837	Belongs to the UPF0109 family
C1O37_RS07145	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1O37_RS07165	COG0534	Mate efflux family protein
C1O37_RS07180	COG0789	Transcriptional regulator
C1O37_RS07185	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1O37_RS07205	COG1408	metallophosphoesterase
C1O37_RS07210	COG0667	Aldo Keto reductase
C1O37_RS07220	COG0656	L-ascorbic acid biosynthetic process
C1O37_RS07230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1O37_RS07250	COG2755	lipolytic protein G-D-S-L family
C1O37_RS07250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1O37_RS07260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS07265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O37_RS07300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1O37_RS07305	COG0154	amidase activity
C1O37_RS07310	COG0714	Associated with various cellular activities
C1O37_RS07325	COG2304	oxidoreductase activity
C1O37_RS07345	COG0656	L-ascorbic acid biosynthetic process
C1O37_RS07350	COG0423	glycine-tRNA ligase activity
C1O37_RS07365	COG0436	Aminotransferase
C1O37_RS07370	COG1522	sequence-specific DNA binding
C1O37_RS07385	COG1401	restriction endodeoxyribonuclease activity
C1O37_RS07385	COG1401	restriction endodeoxyribonuclease activity
C1O37_RS07390	COG2967	ApaG domain
C1O37_RS07400	COG1215	transferase activity, transferring glycosyl groups
C1O37_RS07430	COG1131	(ABC) transporter
C1O37_RS07435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O37_RS07440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C1O37_RS07445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O37_RS07450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O37_RS07460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1O37_RS07465	COG2166	iron-sulfur cluster assembly
C1O37_RS07475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1O37_RS07480	COG3475	LICD family
C1O37_RS07485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O37_RS07495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O37_RS07500	COG3475	LICD family
C1O37_RS07515	COG4106	trans-aconitate 2-methyltransferase activity
C1O37_RS07540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1O37_RS07550	COG0732	type I restriction modification DNA specificity domain
C1O37_RS07565	COG0732	type I restriction modification DNA specificity domain
C1O37_RS07580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1O37_RS07585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1O37_RS07595	COG0113	porphobilinogen synthase activity
C1O37_RS07610	COG2205	protein histidine kinase activity
C1O37_RS07615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O37_RS07670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1O37_RS07675	COG0045	succinate-CoA ligase (ADP-forming) activity
C1O37_RS07680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1O37_RS07695	COG0514	ATP-dependent DNA helicase (RecQ)
C1O37_RS07725	COG2949	membrane
C1O37_RS07750	COG1846	Transcriptional regulator
C1O37_RS07765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1O37_RS07775	COG1271	oxidase subunit
C1O37_RS07780	COG1294	oxidase, subunit
C1O37_RS07800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O37_RS07805	COG0402	S-adenosylhomocysteine deaminase activity
C1O37_RS07825	COG4771	TonB-dependent receptor
C1O37_RS07835	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1O37_RS07840	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1O37_RS07845	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1O37_RS07880	COG0535	radical SAM domain protein
C1O37_RS07900	COG0205	6-phosphofructokinase activity
C1O37_RS07910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1O37_RS07915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1O37_RS07920	COG3250	beta-galactosidase activity
C1O37_RS07925	COG3250	beta-galactosidase activity
C1O37_RS07930	COG3250	beta-galactosidase activity
C1O37_RS07940	COG1166	arginine decarboxylase activity
C1O37_RS07955	COG3119	arylsulfatase activity
C1O37_RS07960	COG0495	leucyl-tRNA aminoacylation
C1O37_RS07965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1O37_RS07970	COG0688	phosphatidylethanolamine metabolic process
C1O37_RS07980	COG0028	Belongs to the TPP enzyme family
C1O37_RS07985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O37_RS07990	COG0268	Binds directly to 16S ribosomal RNA
C1O37_RS08000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1O37_RS08005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O37_RS08025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1O37_RS08040	COG1450	Type ii and iii secretion system protein
C1O37_RS08065	COG1643	Atp-dependent helicase
C1O37_RS08080	COG0793	Belongs to the peptidase S41A family
C1O37_RS08085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1O37_RS08100	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C1O37_RS08105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1O37_RS08110	COG0358	DNA primase activity
C1O37_RS08115	COG1030	water channel activity
C1O37_RS08120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O37_RS08130	COG1640	4-alpha-glucanotransferase
C1O37_RS08135	COG3210	domain, Protein
C1O37_RS08145	COG2264	protein methyltransferase activity
C1O37_RS08150	COG0307	riboflavin synthase, alpha
C1O37_RS08160	COG0726	polysaccharide deacetylase
C1O37_RS08170	COG0649	NAD binding
C1O37_RS08175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C1O37_RS08180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1O37_RS08185	COG1034	ATP synthesis coupled electron transport
C1O37_RS08190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1O37_RS08200	COG0839	Belongs to the complex I subunit 6 family
C1O37_RS08205	COG0713	ATP synthesis coupled electron transport
C1O37_RS08215	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O37_RS08220	COG1007	ATP synthesis coupled electron transport
C1O37_RS08235	COG2151	metal-sulfur cluster biosynthetic enzyme
C1O37_RS08250	COG0142	geranyltranstransferase activity
C1O37_RS08255	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C1O37_RS08260	COG1606	tRNA processing
C1O37_RS08265	COG1691	(AIR) carboxylase
C1O37_RS08270	COG1649	PFAM Uncharacterised BCR, COG1649
C1O37_RS08280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1O37_RS08280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O37_RS08285	COG0728	peptidoglycan biosynthetic process
C1O37_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O37_RS08305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O37_RS08310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O37_RS08315	COG1459	type II secretion system
C1O37_RS08325	COG0463	Glycosyl transferase, family 2
C1O37_RS08330	COG1215	transferase activity, transferring glycosyl groups
C1O37_RS08335	COG0105	UTP biosynthetic process
C1O37_RS08345	COG1187	pseudouridine synthase activity
C1O37_RS08355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1O37_RS08375	COG0372	Belongs to the citrate synthase family
C1O37_RS08400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1O37_RS08410	COG1979	alcohol dehydrogenase
C1O37_RS08415	COG2373	Large extracellular alpha-helical protein
C1O37_RS08420	COG0697	spore germination
C1O37_RS08430	COG1074	ATP-dependent DNA helicase activity
C1O37_RS08450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1O37_RS08455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1O37_RS08460	COG0556	nucleotide-excision repair
C1O37_RS08475	COG2223	nitrite transmembrane transporter activity
C1O37_RS08480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O37_RS08485	COG0561	phosphatase activity
C1O37_RS08520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1O37_RS08530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1O37_RS08535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1O37_RS08550	COG0159	tryptophan synthase activity
C1O37_RS08555	COG0133	tryptophan synthase activity
C1O37_RS08560	COG0135	phosphoribosylanthranilate isomerase activity
C1O37_RS08565	COG0134	indole-3-glycerol-phosphate synthase activity
C1O37_RS08570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1O37_RS08575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O37_RS08590	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1O37_RS08595	COG0667	Aldo Keto reductase
C1O37_RS08650	COG2885	chlorophyll binding
C1O37_RS08665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O37_RS08675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1O37_RS08680	COG0203	ribosomal protein L17
C1O37_RS08685	COG0202	RNA polymerase activity
C1O37_RS08705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O37_RS08705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O37_RS08740	COG1575	Belongs to the MenA family. Type 1 subfamily
C1O37_RS08755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O37_RS08760	COG3273	potassium ion transport
C1O37_RS08760	COG0471	metal ion transport
C1O37_RS08770	COG1561	YicC-like family, N-terminal region
C1O37_RS08775	COG3977	Valine--pyruvate aminotransferase
C1O37_RS08790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1O37_RS08795	COG0428	transporter
C1O37_RS08805	COG0205	6-phosphofructokinase activity
C1O37_RS08810	COG1686	Belongs to the peptidase S11 family
C1O37_RS08825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1O37_RS08830	COG0360	Binds together with S18 to 16S ribosomal RNA
C1O37_RS08835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1O37_RS08840	COG0131	Imidazoleglycerol-phosphate dehydratase
C1O37_RS08850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1O37_RS08855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1O37_RS08880	COG0277	FAD linked oxidase domain protein
C1O37_RS08895	COG5434	Belongs to the glycosyl hydrolase 28 family
C1O37_RS08905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1O37_RS08910	COG0484	heat shock protein binding
C1O37_RS08915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1O37_RS08920	COG1872	DUF167
C1O37_RS08970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1O37_RS08975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1O37_RS08985	COG0765	amino acid transport
C1O37_RS08990	COG1126	abc transporter atp-binding protein
C1O37_RS09015	COG0564	pseudouridine synthase activity
C1O37_RS09020	COG0778	Nitroreductase
C1O37_RS09040	COG0039	L-malate dehydrogenase activity
C1O37_RS09045	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1O37_RS09080	COG0254	rRNA binding
C1O37_RS09085	COG0037	tRNA processing
C1O37_RS09095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1O37_RS09110	COG2271	Major facilitator Superfamily
C1O37_RS09120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1O37_RS09130	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C1O37_RS09140	COG1082	Xylose isomerase domain protein TIM barrel
C1O37_RS09150	COG0126	phosphoglycerate kinase activity
C1O37_RS09160	COG0632	four-way junction helicase activity
C1O37_RS09210	COG0459	protein refolding
C1O37_RS09215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1O37_RS09220	COG0443	Heat shock 70 kDa protein
C1O37_RS09225	COG0438	transferase activity, transferring glycosyl groups
C1O37_RS09245	COG0298	carbon dioxide binding
C1O37_RS09250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1O37_RS09255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1O37_RS09260	COG0124	histidyl-tRNA synthetase
C1O37_RS09265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1O37_RS09285	COG0156	8-amino-7-oxononanoate synthase activity
C1O37_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
C1O37_RS09310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1O37_RS09320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1O37_RS09330	COG1183	phosphatidylcholine synthase activity
C1O37_RS09335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1O37_RS09345	COG1131	(ABC) transporter
C1O37_RS09350	COG0842	Transport permease protein
C1O37_RS09355	COG0842	Transport permease protein
C1O37_RS09375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1O37_RS09380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1O37_RS09385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O37_RS09395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1O37_RS09410	COG0733	neurotransmitter:sodium symporter activity
C1O37_RS09415	COG0450	alkyl hydroperoxide reductase
C1O37_RS09420	COG0668	transmembrane transport
C1O37_RS09425	COG0528	UMP kinase activity
C1O37_RS09430	COG0233	cytoplasmic translational termination
C1O37_RS09475	COG0612	Peptidase, M16
C1O37_RS09490	COG2017	converts alpha-aldose to the beta-anomer
C1O37_RS09500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1O37_RS09510	COG0573	inorganic phosphate transmembrane transporter activity
C1O37_RS09515	COG0581	inorganic phosphate transmembrane transporter activity
C1O37_RS09535	COG0175	sulfate reduction
C1O37_RS09540	COG0175	sulfate reduction
C1O37_RS09545	COG2895	sulfate adenylyltransferase (ATP) activity
C1O37_RS09545	COG0529	Catalyzes the synthesis of activated sulfate
C1O37_RS09565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1O37_RS09585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1O37_RS09590	COG0826	peptidase U32
C1O37_RS09600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1O37_RS09620	COG0545	Peptidyl-prolyl cis-trans isomerase
C1O37_RS09625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1O37_RS09635	COG1408	metallophosphoesterase
C1O37_RS09685	COG3118	belongs to the thioredoxin family
C1O37_RS09685	COG0492	ferredoxin-NADP+ reductase activity
C1O37_RS09690	COG1760	l-serine dehydratase
C1O37_RS09705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1O37_RS09720	COG0259	pyridoxamine-phosphate oxidase activity
C1O37_RS09725	COG0676	glucose-6-phosphate 1-epimerase activity
C1O37_RS09735	COG2755	lipolytic protein G-D-S-L family
C1O37_RS09735	COG0657	acetylesterase activity
C1O37_RS09750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1O37_RS09760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1O37_RS09765	COG0706	membrane insertase activity
C1O37_RS09770	COG0070	glutamate synthase
C1O37_RS09770	COG0069	glutamate synthase activity
C1O37_RS09770	COG0067	glutamate synthase
C1O37_RS09780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O37_RS09785	COG0505	Belongs to the CarA family
C1O37_RS09790	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1O37_RS09795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O37_RS09800	COG1757	Na H antiporter
C1O37_RS09810	COG1482	cell wall glycoprotein biosynthetic process
C1O37_RS09820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O37_RS09825	COG0483	inositol monophosphate 1-phosphatase activity
C1O37_RS09830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1O37_RS09840	COG0848	biopolymer transport protein
C1O37_RS09845	COG0811	peptide transport
C1O37_RS09850	COG0322	excinuclease ABC activity
C1O37_RS09855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1O37_RS09860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1O37_RS09865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1O37_RS09870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1O37_RS09875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1O37_RS09875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1O37_RS09880	COG2003	Belongs to the UPF0758 family
C1O37_RS09900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1O37_RS09905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1O37_RS09925	COG0284	orotidine-5'-phosphate decarboxylase activity
C1O37_RS09975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O37_RS09995	COG0437	4 iron, 4 sulfur cluster binding
C1O37_RS10005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1O37_RS10010	COG3409	Peptidoglycan-binding domain 1 protein
C1O37_RS10010	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1O37_RS10015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1O37_RS10025	COG0736	holo-[acyl-carrier-protein] synthase activity
C1O37_RS10030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1O37_RS10035	COG0138	bifunctional purine biosynthesis protein purh
C1O37_RS10040	COG0359	binds to the 23S rRNA
C1O37_RS10045	COG0598	Magnesium transport protein CorA
C1O37_RS10050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1O37_RS10075	COG1122	ATPase activity
C1O37_RS10080	COG1199	ATP-dependent helicase activity
C1O37_RS10090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1O37_RS10110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1O37_RS10120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1O37_RS10135	COG1477	protein flavinylation
C1O37_RS10140	COG0436	Aminotransferase
C1O37_RS10145	COG0148	phosphopyruvate hydratase activity
C1O37_RS10170	COG2186	Transcriptional regulator
C1O37_RS10175	COG1119	ATPase activity
C1O37_RS10180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1O37_RS10190	COG1090	epimerase
C1O37_RS10210	COG2311	Membrane
C1O37_RS10215	COG0714	Associated with various cellular activities
C1O37_RS10260	COG0789	Transcriptional regulator
C1O37_RS10265	COG0667	Aldo Keto reductase
C1O37_RS10280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O37_RS10290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1O37_RS10295	COG2205	protein histidine kinase activity
C1O37_RS10300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1O37_RS10305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1O37_RS10310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O37_RS10445	COG1876	peptidase activity
C1O37_RS10460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O37_RS10465	COG0534	Mate efflux family protein
C1O37_RS10490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1O37_RS10495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1O37_RS10530	COG1368	sulfuric ester hydrolase activity
C1O37_RS10625	COG0129	dihydroxy-acid dehydratase activity
C1O37_RS10630	COG0745	RESPONSE REGULATOR receiver
C1O37_RS10635	COG5002	protein histidine kinase activity
C1O37_RS10660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1O37_RS10665	COG0006	proline dipeptidase activity
C1O37_RS10675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1O37_RS10680	COG1363	Peptidase, m42
C1O37_RS10710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O37_RS10715	COG2217	Heavy metal translocating P-type atpase
C1O37_RS10720	COG1940	carbohydrate kinase activity
C1O37_RS10725	COG0590	tRNA wobble adenosine to inosine editing
C1O37_RS10730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1O37_RS10735	COG1858	cytochrome C peroxidase
C1O37_RS10790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O37_RS10795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1O37_RS10815	COG0514	ATP-dependent DNA helicase (RecQ)
C1O37_RS10820	COG3119	arylsulfatase activity
C1O37_RS10830	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1O37_RS10830	COG1902	pentaerythritol trinitrate reductase activity
C1O37_RS10845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1O37_RS10850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1O37_RS10855	COG2226	methyltransferase
C1O37_RS10895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O37_RS10915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1O37_RS10930	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1O37_RS10935	COG0740	serine-type endopeptidase activity
C1O37_RS10945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1O37_RS10955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1O37_RS10970	COG0250	Participates in transcription elongation, termination and antitermination
C1O37_RS10975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1O37_RS10980	COG0081	regulation of translation
C1O37_RS10985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1O37_RS10990	COG0222	ribosome binding
C1O37_RS10995	COG0085	RNA polymerase activity
C1O37_RS11000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1O37_RS11020	COG0481	GTPase activity
C1O37_RS11035	COG3119	arylsulfatase activity
C1O37_RS11045	COG0215	cysteine-tRNA ligase activity
C1O37_RS11110	COG0488	(ABC) transporter
C1O37_RS11115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O37_RS11145	COG2095	MarC family integral membrane protein
C1O37_RS11150	COG2267	carboxylic ester hydrolase activity
C1O37_RS11205	COG0667	Aldo Keto reductase
C1O37_RS11215	COG1073	alpha beta
C1O37_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
C1O37_RS11230	COG1253	flavin adenine dinucleotide binding
C1O37_RS11240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1O37_RS11250	COG0488	(ABC) transporter
C1O37_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
C1O37_RS11305	COG1053	succinate dehydrogenase
C1O37_RS11310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1O37_RS11350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O37_RS11355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O37_RS11370	COG0318	PFAM AMP-dependent synthetase and ligase
C1O37_RS11390	COG0339	signal peptide processing
C1O37_RS11400	COG0018	arginyl-trna synthetase
C1O37_RS11435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O37_RS11440	COG0653	protein targeting
C1O37_RS11455	COG0494	nUDIX hydrolase