locus-tag	class	description
DMI73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI73_RS00010	COG1131	(ABC) transporter
DMI73_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMI73_RS00035	COG0564	pseudouridine synthase activity
DMI73_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMI73_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMI73_RS00065	COG0513	Belongs to the DEAD box helicase family
DMI73_RS00075	COG0673	inositol 2-dehydrogenase activity
DMI73_RS00095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DMI73_RS00110	COG1971	Probably functions as a manganese efflux pump
DMI73_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI73_RS00160	COG0442	prolyl-tRNA aminoacylation
DMI73_RS00190	COG0531	amino acid
DMI73_RS00195	COG2066	Belongs to the glutaminase family
DMI73_RS00205	COG1115	amino acid carrier protein
DMI73_RS00215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI73_RS00220	COG2890	protein-(glutamine-N5) methyltransferase activity
DMI73_RS00225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMI73_RS00230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMI73_RS00245	COG2226	methyltransferase
DMI73_RS00250	COG0534	Mate efflux family protein
DMI73_RS00310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI73_RS00315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMI73_RS00320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS00335	COG1121	(ABC) transporter
DMI73_RS00340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMI73_RS00345	COG3880	PFAM UvrB UvrC protein
DMI73_RS00350	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMI73_RS00355	COG0542	response to heat
DMI73_RS00370	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMI73_RS00375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI73_RS00390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMI73_RS00390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI73_RS00405	COG0180	Tryptophanyl-tRNA synthetase
DMI73_RS00415	COG1692	metallophosphoesterase
DMI73_RS00420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMI73_RS00435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMI73_RS00440	COG2816	NAD+ diphosphatase activity
DMI73_RS00445	COG0156	8-amino-7-oxononanoate synthase activity
DMI73_RS00465	COG0515	serine threonine protein kinase
DMI73_RS00465	COG3266	domain, Protein
DMI73_RS00655	COG1598	PFAM Uncharacterised protein family UPF0150
DMI73_RS00725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMI73_RS00745	COG0732	type I restriction modification DNA specificity domain
DMI73_RS00750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMI73_RS00755	COG3189	MarR family transcriptional regulator
DMI73_RS00760	COG0181	hydroxymethylbilane synthase activity
DMI73_RS00765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMI73_RS00775	COG1469	GTP cyclohydrolase I activity
DMI73_RS00780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMI73_RS00785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMI73_RS00795	COG1940	carbohydrate kinase activity
DMI73_RS00810	COG0494	nUDIX hydrolase
DMI73_RS00815	COG1566	PFAM secretion protein HlyD family protein
DMI73_RS00820	COG0577	efflux transmembrane transporter activity
DMI73_RS00820	COG1136	(ABC) transporter
DMI73_RS00825	COG1136	(ABC) transporter
DMI73_RS00825	COG0577	efflux transmembrane transporter activity
DMI73_RS00830	COG1538	Outer membrane efflux protein
DMI73_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI73_RS00855	COG1720	tRNA m6t6A37 methyltransferase activity
DMI73_RS00860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMI73_RS00865	COG0540	Belongs to the ATCase OTCase family
DMI73_RS00870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMI73_RS00885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DMI73_RS00890	COG2957	Belongs to the agmatine deiminase family
DMI73_RS00900	COG0750	zinc metalloprotease
DMI73_RS00910	COG3119	arylsulfatase activity
DMI73_RS00920	COG1918	ferrous iron import across plasma membrane
DMI73_RS00920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI73_RS00970	COG1475	DNA binding
DMI73_RS01015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMI73_RS01020	COG0601	transmembrane transport
DMI73_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMI73_RS01080	COG1132	(ABC) transporter
DMI73_RS01085	COG1132	(ABC) transporter
DMI73_RS01100	COG1127	ABC transporter
DMI73_RS01105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DMI73_RS01135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMI73_RS01150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DMI73_RS01155	COG0504	CTP synthase activity
DMI73_RS01160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMI73_RS01185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI73_RS01195	COG1322	Protein conserved in bacteria
DMI73_RS01200	COG0546	phosphoglycolate phosphatase activity
DMI73_RS01205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI73_RS01215	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI73_RS01245	COG2755	lipolytic protein G-D-S-L family
DMI73_RS01245	COG0657	acetylesterase activity
DMI73_RS01250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMI73_RS01270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMI73_RS01290	COG0335	large ribosomal subunit rRNA binding
DMI73_RS01300	COG0346	lactoylglutathione lyase activity
DMI73_RS01315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMI73_RS01320	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DMI73_RS01325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DMI73_RS01325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DMI73_RS01330	COG0427	acetyl-CoA hydrolase
DMI73_RS01340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DMI73_RS01350	COG0205	6-phosphofructokinase activity
DMI73_RS01360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI73_RS01365	COG0028	Belongs to the TPP enzyme family
DMI73_RS01400	COG0471	metal ion transport
DMI73_RS01410	COG0351	phosphomethylpyrimidine kinase
DMI73_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
DMI73_RS01475	COG0242	peptide deformylase activity
DMI73_RS01480	COG1063	alcohol dehydrogenase
DMI73_RS01490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMI73_RS01495	COG1393	Belongs to the ArsC family
DMI73_RS01500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI73_RS01510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMI73_RS01520	COG1187	pseudouridine synthase activity
DMI73_RS01530	COG0336	Belongs to the RNA methyltransferase TrmD family
DMI73_RS01545	COG0539	negative regulation of cytoplasmic translation
DMI73_RS01590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMI73_RS01595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMI73_RS01600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMI73_RS01605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI73_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI73_RS01665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMI73_RS01665	COG0662	Cupin 2, conserved barrel domain protein
DMI73_RS01680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMI73_RS01690	COG0537	adenosine 5'-monophosphoramidase activity
DMI73_RS01695	COG0009	L-threonylcarbamoyladenylate synthase
DMI73_RS01700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMI73_RS01705	COG0228	four-way junction DNA binding
DMI73_RS01725	COG1862	Preprotein translocase
DMI73_RS01730	COG0343	queuine tRNA-ribosyltransferase activity
DMI73_RS01735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMI73_RS01745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DMI73_RS01750	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMI73_RS01755	COG0776	regulation of translation
DMI73_RS01785	COG0811	peptide transport
DMI73_RS01800	COG3250	beta-galactosidase activity
DMI73_RS01805	COG0525	valine-tRNA ligase activity
DMI73_RS01820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMI73_RS01825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMI73_RS01830	COG0255	Belongs to the universal ribosomal protein uL29 family
DMI73_RS01835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMI73_RS01840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMI73_RS01845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMI73_RS01855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMI73_RS01860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMI73_RS01865	COG0089	rRNA binding
DMI73_RS01870	COG0088	Forms part of the polypeptide exit tunnel
DMI73_RS01875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMI73_RS01880	COG0051	transcription antitermination factor activity, RNA binding
DMI73_RS01885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMI73_RS01890	COG0049	tRNA binding
DMI73_RS01895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMI73_RS01910	COG3852	Histidine kinase
DMI73_RS01915	COG2204	response regulator
DMI73_RS01925	COG1722	exodeoxyribonuclease VII activity
DMI73_RS01930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI73_RS01945	COG0795	lipopolysaccharide-transporting ATPase activity
DMI73_RS01950	COG1160	GTP binding
DMI73_RS01955	COG0444	Belongs to the ABC transporter superfamily
DMI73_RS01975	COG0577	efflux transmembrane transporter activity
DMI73_RS01975	COG1136	(ABC) transporter
DMI73_RS01985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI73_RS02030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMI73_RS02035	COG0799	negative regulation of ribosome biogenesis
DMI73_RS02040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMI73_RS02090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DMI73_RS02105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DMI73_RS02115	COG0300	oxidoreductase activity
DMI73_RS02140	COG0038	chloride channel
DMI73_RS02150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS02170	COG0076	glutamate decarboxylase activity
DMI73_RS02185	COG0167	dihydroorotate dehydrogenase activity
DMI73_RS02190	COG0352	thiamine-phosphate diphosphorylase activity
DMI73_RS02210	COG1253	flavin adenine dinucleotide binding
DMI73_RS02215	COG1253	flavin adenine dinucleotide binding
DMI73_RS02220	COG1185	polyribonucleotide nucleotidyltransferase activity
DMI73_RS02225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMI73_RS02230	COG0110	maltose O-acetyltransferase activity
DMI73_RS02255	COG0101	tRNA pseudouridine synthase activity
DMI73_RS02260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMI73_RS02275	COG4968	Prepilin-type N-terminal cleavage methylation domain
DMI73_RS02290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS02295	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMI73_RS02315	COG1136	(ABC) transporter
DMI73_RS02320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMI73_RS02330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI73_RS02355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS02360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DMI73_RS02365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DMI73_RS02375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMI73_RS02380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMI73_RS02405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI73_RS02410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI73_RS02410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI73_RS02415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMI73_RS02420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMI73_RS02425	COG0552	protein localization to endoplasmic reticulum
DMI73_RS02430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMI73_RS02450	COG1058	Belongs to the CinA family
DMI73_RS02450	COG1546	Belongs to the CinA family
DMI73_RS02460	COG0456	acetyltransferase
DMI73_RS02485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMI73_RS02490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMI73_RS02495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMI73_RS02500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI73_RS02515	COG0758	DNA mediated transformation
DMI73_RS02520	COG1686	Belongs to the peptidase S11 family
DMI73_RS02525	COG0012	GTP binding
DMI73_RS02530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMI73_RS02540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI73_RS02540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI73_RS02555	COG3119	arylsulfatase activity
DMI73_RS02580	COG2259	Doxx family
DMI73_RS02585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMI73_RS02615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI73_RS02635	COG2326	polyphosphate kinase activity
DMI73_RS02640	COG1349	DNA-binding transcription factor activity
DMI73_RS02655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI73_RS02660	COG1162	GTPase activity
DMI73_RS02675	COG0742	ribosomal rna small subunit methyltransferase
DMI73_RS02690	COG2326	polyphosphate kinase activity
DMI73_RS02700	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI73_RS02710	COG1073	alpha beta
DMI73_RS02715	COG0802	atpase or kinase
DMI73_RS02720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMI73_RS02725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMI73_RS02730	COG0735	belongs to the Fur family
DMI73_RS02735	COG0396	ATPase activity
DMI73_RS02740	COG0719	Fe-S assembly protein
DMI73_RS02745	COG0719	Fe-S assembly protein
DMI73_RS02760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMI73_RS02800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI73_RS02820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMI73_RS02825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMI73_RS02830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMI73_RS02835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMI73_RS02840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMI73_RS02845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMI73_RS02855	COG0356	it plays a direct role in the translocation of protons across the membrane
DMI73_RS02905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMI73_RS02930	COG1045	serine acetyltransferase
DMI73_RS02935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMI73_RS02940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMI73_RS02945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMI73_RS02955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMI73_RS02965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMI73_RS02970	COG0047	phosphoribosylformylglycinamidine synthase activity
DMI73_RS02980	COG1363	Peptidase, m42
DMI73_RS02995	COG1077	Cell shape determining protein MreB Mrl
DMI73_RS03000	COG1530	ribonuclease E activity
DMI73_RS03020	COG0848	biopolymer transport protein
DMI73_RS03035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMI73_RS03050	COG0134	indole-3-glycerol-phosphate synthase activity
DMI73_RS03055	COG0792	nuclease activity
DMI73_RS03065	COG1253	flavin adenine dinucleotide binding
DMI73_RS03075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMI73_RS03080	COG0137	argininosuccinate synthase activity
DMI73_RS03095	COG0149	triose-phosphate isomerase activity
DMI73_RS03130	COG1040	competence protein
DMI73_RS03140	COG3956	TIGRFAM MazG family protein
DMI73_RS03160	COG1663	tetraacyldisaccharide 4'-kinase activity
DMI73_RS03170	COG0612	Peptidase, M16
DMI73_RS03185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI73_RS03215	COG0673	inositol 2-dehydrogenase activity
DMI73_RS03220	COG3034	peptidoglycan biosynthetic process
DMI73_RS03240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMI73_RS03245	COG0424	maF-like protein
DMI73_RS03250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMI73_RS03255	COG2815	serine threonine protein kinase
DMI73_RS03255	COG0515	serine threonine protein kinase
DMI73_RS03280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMI73_RS03290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMI73_RS03300	COG0571	ribonuclease III activity
DMI73_RS03320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMI73_RS03335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMI73_RS03355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI73_RS03370	COG2226	methyltransferase
DMI73_RS03380	COG2076	Multidrug Resistance protein
DMI73_RS03615	COG2255	four-way junction helicase activity
DMI73_RS03620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMI73_RS03625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI73_RS03630	COG1215	transferase activity, transferring glycosyl groups
DMI73_RS03635	COG0463	Glycosyl transferase, family 2
DMI73_RS03635	COG1216	Glycosyl transferase, family 2
DMI73_RS03660	COG0438	transferase activity, transferring glycosyl groups
DMI73_RS03670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI73_RS03680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMI73_RS03690	COG0482	sulfurtransferase activity
DMI73_RS03695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMI73_RS03705	COG2860	membrane
DMI73_RS03710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI73_RS03715	COG2001	Belongs to the MraZ family
DMI73_RS03720	COG0275	rRNA processing
DMI73_RS03730	COG0768	penicillin binding
DMI73_RS03735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMI73_RS03740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMI73_RS03745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMI73_RS03750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMI73_RS03760	COG0772	Belongs to the SEDS family
DMI73_RS03765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI73_RS03770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI73_RS03775	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI73_RS03785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMI73_RS03790	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI73_RS03795	COG0321	lipoyl(octanoyl) transferase activity
DMI73_RS03800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMI73_RS03805	COG0066	3-isopropylmalate dehydratase activity
DMI73_RS03815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI73_RS03830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI73_RS03835	COG4608	Belongs to the ABC transporter superfamily
DMI73_RS03840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMI73_RS03845	COG0052	Belongs to the universal ribosomal protein uS2 family
DMI73_RS03855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DMI73_RS03870	COG1137	ATPase activity
DMI73_RS03880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI73_RS03905	COG0017	Asparaginyl-tRNA synthetase
DMI73_RS03915	COG3118	belongs to the thioredoxin family
DMI73_RS03965	COG0583	DNA-binding transcription factor activity
DMI73_RS03970	COG2855	membrane
DMI73_RS03975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI73_RS03985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMI73_RS03995	COG0602	queuosine metabolic process
DMI73_RS04000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI73_RS04005	COG0217	transcriptional regulatory protein
DMI73_RS04010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMI73_RS04015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI73_RS04015	COG4651	solute:proton antiporter activity
DMI73_RS04025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMI73_RS04030	COG4864	UPF0365 protein
DMI73_RS04040	COG2022	thiamine diphosphate biosynthetic process
DMI73_RS04045	COG0531	amino acid
DMI73_RS04055	COG0628	permease
DMI73_RS04060	COG0019	diaminopimelate decarboxylase activity
DMI73_RS04065	COG0191	fructose-bisphosphate aldolase activity
DMI73_RS04070	COG1217	gtp-binding protein TYPA
DMI73_RS04100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMI73_RS04130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI73_RS04135	COG0517	IMP dehydrogenase activity
DMI73_RS04135	COG0516	GMP reductase activity
DMI73_RS04140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI73_RS04140	COG0519	Catalyzes the synthesis of GMP from XMP
DMI73_RS04150	COG0546	phosphoglycolate phosphatase activity
DMI73_RS04170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMI73_RS04185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMI73_RS04190	COG0196	riboflavin kinase activity
DMI73_RS04195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMI73_RS04210	COG1408	metallophosphoesterase
DMI73_RS04220	COG1442	glycosyl transferase family 8
DMI73_RS04220	COG1216	Glycosyl transferase, family 2
DMI73_RS04230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI73_RS04235	COG1216	Glycosyl transferase, family 2
DMI73_RS04255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI73_RS04255	COG2755	lipolytic protein G-D-S-L family
DMI73_RS04270	COG0490	domain, Protein
DMI73_RS04270	COG0471	metal ion transport
DMI73_RS04305	COG0588	phosphoglycerate mutase activity
DMI73_RS04310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMI73_RS04320	COG0477	Major facilitator Superfamily
DMI73_RS04325	COG1607	acyl-coa hydrolase
DMI73_RS04340	COG1525	nuclease
DMI73_RS04355	COG1475	DNA binding
DMI73_RS04360	COG3969	phosphoadenosine phosphosulfate
DMI73_RS04445	COG3015	lipoprotein NlpE involved in copper resistance
DMI73_RS04515	COG0305	Participates in initiation and elongation during chromosome replication
DMI73_RS04610	COG0473	3-isopropylmalate dehydrogenase activity
DMI73_RS04640	COG2873	o-acetylhomoserine
DMI73_RS04645	COG0535	radical SAM domain protein
DMI73_RS04650	COG0535	radical SAM domain protein
DMI73_RS04665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI73_RS04670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMI73_RS04680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMI73_RS04690	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMI73_RS04690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DMI73_RS04690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMI73_RS04690	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMI73_RS04700	COG1733	regulation of RNA biosynthetic process
DMI73_RS04710	COG0107	imidazoleglycerol-phosphate synthase activity
DMI73_RS04720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI73_RS04730	COG1643	Atp-dependent helicase
DMI73_RS04735	COG0440	acetolactate synthase activity
DMI73_RS04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI73_RS04750	COG0445	tRNA wobble uridine modification
DMI73_RS04755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI73_RS04755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI73_RS04760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMI73_RS04770	COG0592	DNA-directed DNA polymerase activity
DMI73_RS04795	COG0791	NLP P60 protein
DMI73_RS04795	COG1388	LysM domain
DMI73_RS04800	COG0084	hydrolase, TatD family'
DMI73_RS04810	COG3250	beta-galactosidase activity
DMI73_RS04825	COG2205	protein histidine kinase activity
DMI73_RS04830	COG0745	RESPONSE REGULATOR receiver
DMI73_RS04840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI73_RS04850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI73_RS04870	COG0542	response to heat
DMI73_RS04915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMI73_RS04925	COG0659	secondary active sulfate transmembrane transporter activity
DMI73_RS04930	COG0165	Argininosuccinate lyase
DMI73_RS04945	COG0148	phosphopyruvate hydratase activity
DMI73_RS04950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMI73_RS04960	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMI73_RS04970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI73_RS04975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMI73_RS05025	COG2985	domain, Protein
DMI73_RS05025	COG0490	domain, Protein
DMI73_RS05040	COG0471	metal ion transport
DMI73_RS05075	COG1592	Rubrerythrin
DMI73_RS05085	COG1363	Peptidase, m42
DMI73_RS05090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS05100	COG1785	Belongs to the alkaline phosphatase family
DMI73_RS05105	COG1970	mechanosensitive ion channel activity
DMI73_RS05110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMI73_RS05130	COG2217	Heavy metal translocating P-type atpase
DMI73_RS05135	COG0497	DNA recombination
DMI73_RS05140	COG0321	lipoyl(octanoyl) transferase activity
DMI73_RS05140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI73_RS05145	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMI73_RS05175	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI73_RS05180	COG0022	dehydrogenase e1 component
DMI73_RS05185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI73_RS05190	COG0789	Transcriptional regulator
DMI73_RS05195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI73_RS05200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI73_RS05205	COG3210	domain, Protein
DMI73_RS05255	COG3409	Peptidoglycan-binding domain 1 protein
DMI73_RS05255	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI73_RS05260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMI73_RS05285	COG1690	Belongs to the RtcB family
DMI73_RS05295	COG2814	Major facilitator Superfamily
DMI73_RS05305	COG2096	Adenosyltransferase
DMI73_RS05315	COG0557	exoribonuclease II activity
DMI73_RS05330	COG0826	peptidase U32
DMI73_RS05335	COG0285	dihydrofolate synthase activity
DMI73_RS05350	COG0673	inositol 2-dehydrogenase activity
DMI73_RS05355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI73_RS05360	COG0737	Belongs to the 5'-nucleotidase family
DMI73_RS05370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI73_RS05375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMI73_RS05390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMI73_RS05395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMI73_RS05400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMI73_RS05405	COG0200	Binds to the 23S rRNA
DMI73_RS05410	COG0201	protein transport
DMI73_RS05415	COG0563	adenylate kinase activity
DMI73_RS05420	COG0024	Methionine aminopeptidase
DMI73_RS05435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMI73_RS05440	COG1442	glycosyl transferase family 8
DMI73_RS05450	COG1216	Glycosyl transferase, family 2
DMI73_RS05460	COG1216	Glycosyl transferase, family 2
DMI73_RS05475	COG1216	Glycosyl transferase, family 2
DMI73_RS05480	COG0693	protein deglycase activity
DMI73_RS05485	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI73_RS05490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMI73_RS05495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI73_RS05505	COG1966	Carbon starvation protein
DMI73_RS05525	COG3119	arylsulfatase activity
DMI73_RS05530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMI73_RS05535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMI73_RS05540	COG0195	Participates in both transcription termination and antitermination
DMI73_RS05545	COG0708	Exodeoxyribonuclease III
DMI73_RS05550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMI73_RS05555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMI73_RS05560	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DMI73_RS05570	COG1131	(ABC) transporter
DMI73_RS05570	COG0842	Transport permease protein
DMI73_RS05570	COG1716	ATPase activity
DMI73_RS05590	COG0724	RNA recognition motif
DMI73_RS05595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI73_RS05615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMI73_RS05620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI73_RS05625	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DMI73_RS05630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMI73_RS05645	COG1490	D-aminoacyl-tRNA deacylase activity
DMI73_RS05660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMI73_RS05665	COG1053	succinate dehydrogenase
DMI73_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
DMI73_RS05720	COG0488	(ABC) transporter
DMI73_RS05730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMI73_RS05740	COG1253	flavin adenine dinucleotide binding
DMI73_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
DMI73_RS05755	COG1073	alpha beta
DMI73_RS05765	COG0667	Aldo Keto reductase
DMI73_RS05820	COG2267	carboxylic ester hydrolase activity
DMI73_RS05825	COG2095	MarC family integral membrane protein
DMI73_RS05865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI73_RS05870	COG0488	(ABC) transporter
DMI73_RS05880	COG0697	spore germination
DMI73_RS05890	COG0215	cysteine-tRNA ligase activity
DMI73_RS05900	COG3119	arylsulfatase activity
DMI73_RS05915	COG0481	GTPase activity
DMI73_RS05935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMI73_RS05940	COG0085	RNA polymerase activity
DMI73_RS05945	COG0222	ribosome binding
DMI73_RS05950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMI73_RS05955	COG0081	regulation of translation
DMI73_RS05960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMI73_RS05965	COG0250	Participates in transcription elongation, termination and antitermination
DMI73_RS05980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMI73_RS06000	COG0740	serine-type endopeptidase activity
DMI73_RS06005	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMI73_RS06020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMI73_RS06040	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI73_RS06080	COG2226	methyltransferase
DMI73_RS06085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMI73_RS06090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMI73_RS06105	COG1902	pentaerythritol trinitrate reductase activity
DMI73_RS06105	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMI73_RS06115	COG3119	arylsulfatase activity
DMI73_RS06120	COG0514	ATP-dependent DNA helicase (RecQ)
DMI73_RS06145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMI73_RS06150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMI73_RS06205	COG1858	cytochrome C peroxidase
DMI73_RS06210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMI73_RS06215	COG0590	tRNA wobble adenosine to inosine editing
DMI73_RS06220	COG1940	carbohydrate kinase activity
DMI73_RS06225	COG2217	Heavy metal translocating P-type atpase
DMI73_RS06230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI73_RS06235	COG0237	dephospho-CoA kinase activity
DMI73_RS06265	COG1363	Peptidase, m42
DMI73_RS06270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMI73_RS06280	COG0006	proline dipeptidase activity
DMI73_RS06285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMI73_RS06295	COG5002	protein histidine kinase activity
DMI73_RS06300	COG0745	RESPONSE REGULATOR receiver
DMI73_RS06305	COG0129	dihydroxy-acid dehydratase activity
DMI73_RS06330	COG1368	sulfuric ester hydrolase activity
DMI73_RS06365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI73_RS06390	COG0534	Mate efflux family protein
DMI73_RS06395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI73_RS06410	COG1876	peptidase activity
DMI73_RS06455	COG3209	COG3209 Rhs family protein
DMI73_RS06505	COG3209	COG3209 Rhs family protein
DMI73_RS06555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI73_RS06560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DMI73_RS06565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI73_RS06570	COG2205	protein histidine kinase activity
DMI73_RS06575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI73_RS06585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI73_RS06600	COG0667	Aldo Keto reductase
DMI73_RS06605	COG0789	Transcriptional regulator
DMI73_RS06650	COG0714	Associated with various cellular activities
DMI73_RS06655	COG2311	Membrane
DMI73_RS06675	COG1090	epimerase
DMI73_RS06685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMI73_RS06690	COG1119	ATPase activity
DMI73_RS06695	COG2186	Transcriptional regulator
DMI73_RS06715	COG0148	phosphopyruvate hydratase activity
DMI73_RS06720	COG0436	Aminotransferase
DMI73_RS06725	COG1477	protein flavinylation
DMI73_RS06740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMI73_RS06750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMI73_RS06770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMI73_RS06780	COG1199	ATP-dependent helicase activity
DMI73_RS06785	COG1122	ATPase activity
DMI73_RS06810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI73_RS06815	COG0598	Magnesium transport protein CorA
DMI73_RS06820	COG0359	binds to the 23S rRNA
DMI73_RS06825	COG0138	bifunctional purine biosynthesis protein purh
DMI73_RS06830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DMI73_RS06835	COG0736	holo-[acyl-carrier-protein] synthase activity
DMI73_RS06845	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMI73_RS06850	COG3409	Peptidoglycan-binding domain 1 protein
DMI73_RS06850	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI73_RS06855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMI73_RS06865	COG0437	4 iron, 4 sulfur cluster binding
DMI73_RS06885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI73_RS06940	COG0284	orotidine-5'-phosphate decarboxylase activity
DMI73_RS06960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMI73_RS06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMI73_RS06985	COG2003	Belongs to the UPF0758 family
DMI73_RS06990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DMI73_RS06990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMI73_RS06995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMI73_RS07000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMI73_RS07005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMI73_RS07010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMI73_RS07015	COG0322	excinuclease ABC activity
DMI73_RS07020	COG0811	peptide transport
DMI73_RS07025	COG0848	biopolymer transport protein
DMI73_RS07035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI73_RS07040	COG0483	inositol monophosphate 1-phosphatase activity
DMI73_RS07045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI73_RS07055	COG1482	cell wall glycoprotein biosynthetic process
DMI73_RS07065	COG1757	Na H antiporter
DMI73_RS07070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI73_RS07075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DMI73_RS07080	COG0505	Belongs to the CarA family
DMI73_RS07085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI73_RS07095	COG0069	glutamate synthase activity
DMI73_RS07095	COG0070	glutamate synthase
DMI73_RS07095	COG0067	glutamate synthase
DMI73_RS07105	COG0706	membrane insertase activity
DMI73_RS07110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMI73_RS07120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMI73_RS07135	COG2755	lipolytic protein G-D-S-L family
DMI73_RS07135	COG0657	acetylesterase activity
DMI73_RS07145	COG0676	glucose-6-phosphate 1-epimerase activity
DMI73_RS07150	COG0259	pyridoxamine-phosphate oxidase activity
DMI73_RS07165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMI73_RS07180	COG1760	l-serine dehydratase
DMI73_RS07185	COG3118	belongs to the thioredoxin family
DMI73_RS07185	COG0492	ferredoxin-NADP+ reductase activity
DMI73_RS07235	COG1408	metallophosphoesterase
DMI73_RS07245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMI73_RS07250	COG0545	Peptidyl-prolyl cis-trans isomerase
DMI73_RS07265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMI73_RS07275	COG0826	peptidase U32
DMI73_RS07285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI73_RS07315	COG0581	inorganic phosphate transmembrane transporter activity
DMI73_RS07320	COG0573	inorganic phosphate transmembrane transporter activity
DMI73_RS07330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMI73_RS07340	COG2017	converts alpha-aldose to the beta-anomer
DMI73_RS07355	COG0612	Peptidase, M16
DMI73_RS07385	COG0233	cytoplasmic translational termination
DMI73_RS07390	COG0528	UMP kinase activity
DMI73_RS07395	COG0668	transmembrane transport
DMI73_RS07400	COG0450	alkyl hydroperoxide reductase
DMI73_RS07405	COG0733	neurotransmitter:sodium symporter activity
DMI73_RS07420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMI73_RS07430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMI73_RS07435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMI73_RS07440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMI73_RS07465	COG0842	Transport permease protein
DMI73_RS07470	COG0842	Transport permease protein
DMI73_RS07475	COG1131	(ABC) transporter
DMI73_RS07485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMI73_RS07490	COG1183	phosphatidylcholine synthase activity
DMI73_RS07500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMI73_RS07510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMI73_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
DMI73_RS07535	COG0156	8-amino-7-oxononanoate synthase activity
DMI73_RS07555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMI73_RS07560	COG0124	histidyl-tRNA synthetase
DMI73_RS07565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMI73_RS07570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DMI73_RS07575	COG0298	carbon dioxide binding
DMI73_RS07600	COG0438	transferase activity, transferring glycosyl groups
DMI73_RS07605	COG0443	Heat shock 70 kDa protein
DMI73_RS07610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMI73_RS07615	COG0459	protein refolding
DMI73_RS07670	COG0632	four-way junction helicase activity
DMI73_RS07680	COG0126	phosphoglycerate kinase activity
DMI73_RS07690	COG1082	Xylose isomerase domain protein TIM barrel
DMI73_RS07695	COG2815	serine threonine protein kinase
DMI73_RS07695	COG0515	serine threonine protein kinase
DMI73_RS07700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMI73_RS07710	COG2271	Major facilitator Superfamily
DMI73_RS07725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMI73_RS07735	COG0037	tRNA processing
DMI73_RS07740	COG0254	rRNA binding
DMI73_RS07775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DMI73_RS07780	COG0039	L-malate dehydrogenase activity
DMI73_RS08015	COG0778	Nitroreductase
DMI73_RS08020	COG0564	pseudouridine synthase activity
DMI73_RS08040	COG1126	abc transporter atp-binding protein
DMI73_RS08045	COG0765	amino acid transport
DMI73_RS08055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMI73_RS08060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMI73_RS08080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI73_RS08105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMI73_RS08110	COG1872	DUF167
DMI73_RS08115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMI73_RS08120	COG0484	heat shock protein binding
DMI73_RS08125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMI73_RS08135	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI73_RS08150	COG0277	FAD linked oxidase domain protein
DMI73_RS08175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMI73_RS08180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMI73_RS08190	COG0131	Imidazoleglycerol-phosphate dehydratase
DMI73_RS08195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMI73_RS08200	COG0360	Binds together with S18 to 16S ribosomal RNA
DMI73_RS08205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DMI73_RS08220	COG1686	Belongs to the peptidase S11 family
DMI73_RS08225	COG0205	6-phosphofructokinase activity
DMI73_RS08235	COG0428	transporter
DMI73_RS08240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI73_RS08260	COG3977	Valine--pyruvate aminotransferase
DMI73_RS08265	COG1561	YicC-like family, N-terminal region
DMI73_RS08275	COG3273	potassium ion transport
DMI73_RS08275	COG0471	metal ion transport
DMI73_RS08280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI73_RS08295	COG1575	Belongs to the MenA family. Type 1 subfamily
DMI73_RS08330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI73_RS08330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI73_RS08350	COG0202	RNA polymerase activity
DMI73_RS08355	COG0203	ribosomal protein L17
DMI73_RS08360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DMI73_RS08365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI73_RS08380	COG2885	chlorophyll binding
DMI73_RS08450	COG0667	Aldo Keto reductase
DMI73_RS08455	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DMI73_RS08470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI73_RS08475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI73_RS08480	COG0134	indole-3-glycerol-phosphate synthase activity
DMI73_RS08485	COG0135	phosphoribosylanthranilate isomerase activity
DMI73_RS08495	COG0159	tryptophan synthase activity
DMI73_RS08510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMI73_RS08515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMI73_RS08525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMI73_RS08560	COG0561	phosphatase activity
DMI73_RS08565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI73_RS08570	COG2223	nitrite transmembrane transporter activity
DMI73_RS08575	COG1111	helicase
DMI73_RS08575	COG1205	dead DEAH box helicase
DMI73_RS08580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI73_RS08615	COG0556	nucleotide-excision repair
DMI73_RS08620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMI73_RS08625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMI73_RS08630	COG0750	zinc metalloprotease
DMI73_RS08645	COG1074	ATP-dependent DNA helicase activity
DMI73_RS08655	COG0697	spore germination
DMI73_RS08665	COG1002	Type II restriction enzyme, methylase subunits
DMI73_RS08670	COG1061	Type III restriction enzyme res subunit
DMI73_RS08675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMI73_RS08680	COG2373	Large extracellular alpha-helical protein
DMI73_RS08685	COG1979	alcohol dehydrogenase
DMI73_RS08695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMI73_RS08720	COG0372	Belongs to the citrate synthase family
DMI73_RS08735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMI73_RS08745	COG1187	pseudouridine synthase activity
DMI73_RS08755	COG0105	UTP biosynthetic process
DMI73_RS08760	COG1215	transferase activity, transferring glycosyl groups
DMI73_RS08765	COG0463	Glycosyl transferase, family 2
DMI73_RS08775	COG1459	type II secretion system
DMI73_RS08780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI73_RS08785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI73_RS08790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI73_RS08805	COG0728	peptidoglycan biosynthetic process
DMI73_RS08810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI73_RS08810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI73_RS08820	COG1649	PFAM Uncharacterised BCR, COG1649
DMI73_RS08825	COG1691	(AIR) carboxylase
DMI73_RS08830	COG0037	tRNA processing
DMI73_RS08835	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMI73_RS08840	COG0142	geranyltranstransferase activity
DMI73_RS08855	COG2151	metal-sulfur cluster biosynthetic enzyme
DMI73_RS08875	COG1007	ATP synthesis coupled electron transport
DMI73_RS08880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI73_RS08890	COG0713	ATP synthesis coupled electron transport
DMI73_RS08895	COG0839	Belongs to the complex I subunit 6 family
DMI73_RS08905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DMI73_RS08910	COG1034	ATP synthesis coupled electron transport
DMI73_RS08915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMI73_RS08920	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DMI73_RS08935	COG0726	polysaccharide deacetylase
DMI73_RS08945	COG0307	riboflavin synthase, alpha
DMI73_RS08950	COG2264	protein methyltransferase activity
DMI73_RS08960	COG3210	domain, Protein
DMI73_RS08965	COG1640	4-alpha-glucanotransferase
DMI73_RS08975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI73_RS08980	COG1030	water channel activity
DMI73_RS08985	COG0358	DNA primase activity
DMI73_RS08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMI73_RS08995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DMI73_RS09010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMI73_RS09015	COG0793	Belongs to the peptidase S41A family
DMI73_RS09030	COG1643	Atp-dependent helicase
DMI73_RS09055	COG1450	Type ii and iii secretion system protein
DMI73_RS09070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMI73_RS09090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI73_RS09095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMI73_RS09105	COG0268	Binds directly to 16S ribosomal RNA
DMI73_RS09110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI73_RS09115	COG0028	Belongs to the TPP enzyme family
DMI73_RS09125	COG0688	phosphatidylethanolamine metabolic process
DMI73_RS09130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMI73_RS09135	COG0495	leucyl-tRNA aminoacylation
DMI73_RS09140	COG3119	arylsulfatase activity
DMI73_RS09155	COG1166	arginine decarboxylase activity
DMI73_RS09165	COG3250	beta-galactosidase activity
DMI73_RS09170	COG3250	beta-galactosidase activity
DMI73_RS09175	COG3250	beta-galactosidase activity
DMI73_RS09180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMI73_RS09185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS09195	COG0205	6-phosphofructokinase activity
DMI73_RS09230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DMI73_RS09235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DMI73_RS09240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DMI73_RS09250	COG4771	TonB-dependent receptor
DMI73_RS09270	COG0402	S-adenosylhomocysteine deaminase activity
DMI73_RS09275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMI73_RS09295	COG1196	nuclear chromosome segregation
DMI73_RS09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI73_RS09340	COG1294	oxidase, subunit
DMI73_RS09345	COG1271	oxidase subunit
DMI73_RS09370	COG1846	Transcriptional regulator
DMI73_RS09400	COG2949	membrane
DMI73_RS09425	COG0514	ATP-dependent DNA helicase (RecQ)
DMI73_RS09440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMI73_RS09445	COG0045	succinate-CoA ligase (ADP-forming) activity
DMI73_RS09450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMI73_RS09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI73_RS09515	COG2205	protein histidine kinase activity
DMI73_RS09530	COG0113	porphobilinogen synthase activity
DMI73_RS09540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMI73_RS09545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMI73_RS09560	COG0732	type I restriction modification DNA specificity domain
DMI73_RS09575	COG0732	type I restriction modification DNA specificity domain
DMI73_RS09585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMI73_RS09610	COG4106	trans-aconitate 2-methyltransferase activity
DMI73_RS09625	COG3475	LICD family
DMI73_RS09630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI73_RS09640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI73_RS09645	COG3475	LICD family
DMI73_RS09650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMI73_RS09660	COG2166	iron-sulfur cluster assembly
DMI73_RS09665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMI73_RS09675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI73_RS09680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMI73_RS09685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMI73_RS09690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMI73_RS09695	COG1131	(ABC) transporter
DMI73_RS09725	COG1215	transferase activity, transferring glycosyl groups
DMI73_RS09735	COG2967	ApaG domain
DMI73_RS09745	COG1522	sequence-specific DNA binding
DMI73_RS09750	COG0436	Aminotransferase
DMI73_RS09765	COG0423	glycine-tRNA ligase activity
DMI73_RS09770	COG0656	L-ascorbic acid biosynthetic process
DMI73_RS09785	COG2304	oxidoreductase activity
DMI73_RS09805	COG0714	Associated with various cellular activities
DMI73_RS09810	COG0154	amidase activity
DMI73_RS09815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI73_RS09855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI73_RS09865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI73_RS09865	COG2755	lipolytic protein G-D-S-L family
DMI73_RS09885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI73_RS09895	COG0656	L-ascorbic acid biosynthetic process
DMI73_RS09905	COG0667	Aldo Keto reductase
DMI73_RS09910	COG1408	metallophosphoesterase
DMI73_RS09930	COG2249	NAD(P)H dehydrogenase (quinone) activity
DMI73_RS09935	COG0789	Transcriptional regulator
DMI73_RS09950	COG0534	Mate efflux family protein
DMI73_RS09970	COG1091	dTDP-4-dehydrorhamnose reductase activity
DMI73_RS09985	COG1837	Belongs to the UPF0109 family
DMI73_RS09990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI73_RS09995	COG0363	glucosamine-6-phosphate deaminase activity
DMI73_RS10015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DMI73_RS10025	COG1741	Belongs to the pirin family
DMI73_RS10040	COG1070	Carbohydrate kinase
DMI73_RS10055	COG0738	Major facilitator superfamily
DMI73_RS10070	COG1595	DNA-templated transcription, initiation
DMI73_RS10090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMI73_RS10110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI73_RS10120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DMI73_RS10125	COG2132	Multicopper oxidase
DMI73_RS10130	COG0697	spore germination
DMI73_RS10135	COG3586	endonuclease activity
DMI73_RS10145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI73_RS10150	COG4608	Belongs to the ABC transporter superfamily
DMI73_RS10155	COG0444	Belongs to the ABC transporter superfamily
DMI73_RS10160	COG4166	transmembrane transport
DMI73_RS10165	COG4239	(ABC) transporter, permease
DMI73_RS10170	COG0601	transmembrane transport
DMI73_RS10190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMI73_RS10195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMI73_RS10200	COG3738	Protein conserved in bacteria
DMI73_RS10205	COG0151	Belongs to the GarS family
DMI73_RS10220	COG0811	peptide transport
DMI73_RS10230	COG0242	peptide deformylase activity
DMI73_RS10265	COG2010	Cytochrome c
DMI73_RS10275	COG3258	Cytochrome c
DMI73_RS10290	COG3274	enterobacterial common antigen metabolic process
DMI73_RS10295	COG0538	isocitrate dehydrogenase activity
DMI73_RS10310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI73_RS10315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMI73_RS10320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMI73_RS10330	COG0668	transmembrane transport
DMI73_RS10335	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DMI73_RS10335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI73_RS10340	COG0805	protein transport
DMI73_RS10345	COG1968	undecaprenyl-diphosphatase activity
DMI73_RS10365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMI73_RS10380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMI73_RS10390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMI73_RS10400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI73_RS10410	COG1408	metallophosphoesterase
DMI73_RS10435	COG4974	Belongs to the 'phage' integrase family
DMI73_RS10455	COG1454	alcohol dehydrogenase
DMI73_RS10460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMI73_RS10470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DMI73_RS10470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMI73_RS10475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DMI73_RS10525	COG4607	ABC-type enterochelin transport system periplasmic component
DMI73_RS10530	COG4604	ABC transporter, ATP-binding protein
DMI73_RS10535	COG4605	iron ion homeostasis
DMI73_RS10540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMI73_RS10575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI73_RS10575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI73_RS10590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMI73_RS10595	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMI73_RS10615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI73_RS10635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI73_RS10660	COG0519	Catalyzes the synthesis of GMP from XMP
DMI73_RS10660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI73_RS10665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMI73_RS10700	COG2966	Psort location CytoplasmicMembrane, score
DMI73_RS10705	COG3610	response to peptide
DMI73_RS10715	COG0460	homoserine dehydrogenase
DMI73_RS10720	COG0527	aspartate kinase activity
DMI73_RS10730	COG5522	Integral membrane protein (intg_mem_TP0381)
DMI73_RS10740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMI73_RS10745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMI73_RS10750	COG1194	a g-specific adenine glycosylase
DMI73_RS10755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DMI73_RS10760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI73_RS10760	COG0574	Belongs to the PEP-utilizing enzyme family
DMI73_RS10765	COG0166	Belongs to the GPI family
DMI73_RS10775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI73_RS10800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI73_RS10800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI73_RS10835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMI73_RS10840	COG2818	Glycosylase
DMI73_RS10860	COG3033	Beta-eliminating lyase
DMI73_RS10875	COG0072	phenylalanine-tRNA ligase activity
DMI73_RS10875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI73_RS10890	COG3059	membrane
DMI73_RS10900	COG0326	Molecular chaperone. Has ATPase activity
DMI73_RS10925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI73_RS10930	COG1959	2 iron, 2 sulfur cluster binding
DMI73_RS10945	COG0352	thiamine-phosphate diphosphorylase activity
DMI73_RS10950	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMI73_RS10965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS10975	COG1703	isobutyryl-CoA mutase activity
DMI73_RS10995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMI73_RS11005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI73_RS11010	COG0418	dihydroorotase activity
DMI73_RS11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI73_RS11045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMI73_RS11075	COG0534	Mate efflux family protein
DMI73_RS11080	COG0489	protein tyrosine kinase activity
DMI73_RS11090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI73_RS11100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI73_RS11110	COG1538	Outer membrane efflux protein
DMI73_RS11130	COG4112	unkown
DMI73_RS11145	COG0038	chloride channel
DMI73_RS11170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMI73_RS11180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI73_RS11185	COG0586	Pfam SNARE associated Golgi protein
DMI73_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
DMI73_RS11270	COG0753	catalase activity
DMI73_RS11280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI73_RS11285	COG1592	Rubrerythrin
DMI73_RS11290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMI73_RS11310	COG0489	protein tyrosine kinase activity
DMI73_RS11320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI73_RS11330	COG2244	polysaccharide biosynthetic process
DMI73_RS11335	COG1216	Glycosyl transferase, family 2
DMI73_RS11345	COG1216	Glycosyl transferase, family 2
DMI73_RS11355	COG0438	transferase activity, transferring glycosyl groups
DMI73_RS11360	COG0438	transferase activity, transferring glycosyl groups
DMI73_RS11390	COG1216	Glycosyl transferase, family 2
DMI73_RS11435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI73_RS11440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI73_RS11445	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMI73_RS11455	COG0280	phosphate acetyltransferase
DMI73_RS11455	COG0281	malic enzyme
DMI73_RS11470	COG1472	Belongs to the glycosyl hydrolase 3 family
DMI73_RS11475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMI73_RS11490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMI73_RS11505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMI73_RS11510	COG1063	alcohol dehydrogenase
DMI73_RS11525	COG0714	Associated with various cellular activities
DMI73_RS11535	COG0193	aminoacyl-tRNA hydrolase activity
DMI73_RS11540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI73_RS11555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMI73_RS11580	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DMI73_RS11595	COG0375	protein maturation
DMI73_RS11620	COG0778	Nitroreductase
DMI73_RS11625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI73_RS11645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI73_RS11645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI73_RS11660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI73_RS11660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI73_RS11680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI73_RS11685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMI73_RS11690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMI73_RS11750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI73_RS11755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI73_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
DMI73_RS11800	COG0339	signal peptide processing
DMI73_RS11810	COG0018	arginyl-trna synthetase
DMI73_RS11855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI73_RS11860	COG0653	protein targeting
DMI73_RS11875	COG0494	nUDIX hydrolase
DMI73_RS11885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DMI73_RS11895	COG2814	Major facilitator Superfamily
DMI73_RS11905	COG0471	metal ion transport
DMI73_RS11905	COG0490	domain, Protein
DMI73_RS11930	COG1882	Formate acetyltransferase
DMI73_RS11960	COG2217	Heavy metal translocating P-type atpase