locus-tag	class	description
DMI74_RS00040	COG0534	Mate efflux family protein
DMI74_RS00045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI74_RS00060	COG1876	peptidase activity
DMI74_RS00105	COG3209	COG3209 Rhs family protein
DMI74_RS00155	COG3209	COG3209 Rhs family protein
DMI74_RS00205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI74_RS00210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DMI74_RS00215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI74_RS00220	COG2205	protein histidine kinase activity
DMI74_RS00225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI74_RS00235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI74_RS00250	COG0667	Aldo Keto reductase
DMI74_RS00255	COG0789	Transcriptional regulator
DMI74_RS00300	COG0714	Associated with various cellular activities
DMI74_RS00305	COG2311	Membrane
DMI74_RS00325	COG1090	epimerase
DMI74_RS00335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMI74_RS00340	COG1119	ATPase activity
DMI74_RS00345	COG2186	Transcriptional regulator
DMI74_RS00365	COG0148	phosphopyruvate hydratase activity
DMI74_RS00370	COG0436	Aminotransferase
DMI74_RS00375	COG1477	protein flavinylation
DMI74_RS00390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMI74_RS00400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMI74_RS00420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMI74_RS00430	COG1199	ATP-dependent helicase activity
DMI74_RS00435	COG1122	ATPase activity
DMI74_RS00460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI74_RS00465	COG0598	Magnesium transport protein CorA
DMI74_RS00470	COG0359	binds to the 23S rRNA
DMI74_RS00475	COG0138	bifunctional purine biosynthesis protein purh
DMI74_RS00480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DMI74_RS00485	COG0736	holo-[acyl-carrier-protein] synthase activity
DMI74_RS00495	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMI74_RS00500	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI74_RS00500	COG3409	Peptidoglycan-binding domain 1 protein
DMI74_RS00505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMI74_RS00515	COG0437	4 iron, 4 sulfur cluster binding
DMI74_RS00535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI74_RS00585	COG0284	orotidine-5'-phosphate decarboxylase activity
DMI74_RS00605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMI74_RS00610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMI74_RS00630	COG2003	Belongs to the UPF0758 family
DMI74_RS00635	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DMI74_RS00635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMI74_RS00640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMI74_RS00645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMI74_RS00650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMI74_RS00655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMI74_RS00660	COG0322	excinuclease ABC activity
DMI74_RS00665	COG0811	peptide transport
DMI74_RS00670	COG0848	biopolymer transport protein
DMI74_RS00680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI74_RS00685	COG0483	inositol monophosphate 1-phosphatase activity
DMI74_RS00690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI74_RS00700	COG1482	cell wall glycoprotein biosynthetic process
DMI74_RS00710	COG1757	Na H antiporter
DMI74_RS00715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI74_RS00720	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DMI74_RS00725	COG0505	Belongs to the CarA family
DMI74_RS00730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI74_RS00740	COG0067	glutamate synthase
DMI74_RS00740	COG0070	glutamate synthase
DMI74_RS00740	COG0069	glutamate synthase activity
DMI74_RS00750	COG0706	membrane insertase activity
DMI74_RS00755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMI74_RS00765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMI74_RS00780	COG2755	lipolytic protein G-D-S-L family
DMI74_RS00780	COG0657	acetylesterase activity
DMI74_RS00790	COG0676	glucose-6-phosphate 1-epimerase activity
DMI74_RS00795	COG0259	pyridoxamine-phosphate oxidase activity
DMI74_RS00810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMI74_RS00825	COG1760	l-serine dehydratase
DMI74_RS00830	COG3118	belongs to the thioredoxin family
DMI74_RS00830	COG0492	ferredoxin-NADP+ reductase activity
DMI74_RS00880	COG1408	metallophosphoesterase
DMI74_RS00890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMI74_RS00895	COG0545	Peptidyl-prolyl cis-trans isomerase
DMI74_RS00910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMI74_RS00920	COG0826	peptidase U32
DMI74_RS00930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI74_RS00960	COG0581	inorganic phosphate transmembrane transporter activity
DMI74_RS00965	COG0573	inorganic phosphate transmembrane transporter activity
DMI74_RS00975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMI74_RS00985	COG2017	converts alpha-aldose to the beta-anomer
DMI74_RS01000	COG0612	Peptidase, M16
DMI74_RS01030	COG0233	cytoplasmic translational termination
DMI74_RS01035	COG0528	UMP kinase activity
DMI74_RS01040	COG0668	transmembrane transport
DMI74_RS01045	COG0450	alkyl hydroperoxide reductase
DMI74_RS01050	COG0733	neurotransmitter:sodium symporter activity
DMI74_RS01065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMI74_RS01075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMI74_RS01080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMI74_RS01085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMI74_RS01105	COG0842	Transport permease protein
DMI74_RS01110	COG0842	Transport permease protein
DMI74_RS01115	COG1131	(ABC) transporter
DMI74_RS01125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMI74_RS01130	COG1183	phosphatidylcholine synthase activity
DMI74_RS01140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMI74_RS01150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMI74_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
DMI74_RS01175	COG0156	8-amino-7-oxononanoate synthase activity
DMI74_RS01195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMI74_RS01200	COG0124	histidyl-tRNA synthetase
DMI74_RS01205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMI74_RS01210	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DMI74_RS01215	COG0298	carbon dioxide binding
DMI74_RS01240	COG0438	transferase activity, transferring glycosyl groups
DMI74_RS01245	COG0443	Heat shock 70 kDa protein
DMI74_RS01250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMI74_RS01255	COG0459	protein refolding
DMI74_RS01305	COG0632	four-way junction helicase activity
DMI74_RS01315	COG0126	phosphoglycerate kinase activity
DMI74_RS01325	COG1082	Xylose isomerase domain protein TIM barrel
DMI74_RS01330	COG0515	serine threonine protein kinase
DMI74_RS01330	COG2815	serine threonine protein kinase
DMI74_RS01335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMI74_RS01345	COG2271	Major facilitator Superfamily
DMI74_RS01360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMI74_RS01370	COG0037	tRNA processing
DMI74_RS01375	COG0254	rRNA binding
DMI74_RS01410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DMI74_RS01415	COG0039	L-malate dehydrogenase activity
DMI74_RS01650	COG0778	Nitroreductase
DMI74_RS01655	COG0564	pseudouridine synthase activity
DMI74_RS01675	COG1126	abc transporter atp-binding protein
DMI74_RS01680	COG0765	amino acid transport
DMI74_RS01690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMI74_RS01695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMI74_RS01715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI74_RS01740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMI74_RS01745	COG1872	DUF167
DMI74_RS01750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMI74_RS01755	COG0484	heat shock protein binding
DMI74_RS01760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMI74_RS01770	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI74_RS01785	COG0277	FAD linked oxidase domain protein
DMI74_RS01810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMI74_RS01815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMI74_RS01825	COG0131	Imidazoleglycerol-phosphate dehydratase
DMI74_RS01830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMI74_RS01835	COG0360	Binds together with S18 to 16S ribosomal RNA
DMI74_RS01840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DMI74_RS01855	COG1686	Belongs to the peptidase S11 family
DMI74_RS01860	COG0205	6-phosphofructokinase activity
DMI74_RS01870	COG0428	transporter
DMI74_RS01875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI74_RS01895	COG3977	Valine--pyruvate aminotransferase
DMI74_RS01900	COG1561	YicC-like family, N-terminal region
DMI74_RS01910	COG3273	potassium ion transport
DMI74_RS01910	COG0471	metal ion transport
DMI74_RS01915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI74_RS01930	COG1575	Belongs to the MenA family. Type 1 subfamily
DMI74_RS01965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI74_RS01965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI74_RS01985	COG0202	RNA polymerase activity
DMI74_RS01990	COG0203	ribosomal protein L17
DMI74_RS01995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DMI74_RS02000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI74_RS02015	COG2885	chlorophyll binding
DMI74_RS02085	COG0667	Aldo Keto reductase
DMI74_RS02090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DMI74_RS02105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI74_RS02110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI74_RS02115	COG0134	indole-3-glycerol-phosphate synthase activity
DMI74_RS02120	COG0135	phosphoribosylanthranilate isomerase activity
DMI74_RS02130	COG0159	tryptophan synthase activity
DMI74_RS02145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMI74_RS02150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMI74_RS02160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMI74_RS02195	COG0561	phosphatase activity
DMI74_RS02200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI74_RS02205	COG2223	nitrite transmembrane transporter activity
DMI74_RS02210	COG1205	dead DEAH box helicase
DMI74_RS02210	COG1111	helicase
DMI74_RS02215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI74_RS02250	COG0556	nucleotide-excision repair
DMI74_RS02255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMI74_RS02260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMI74_RS02265	COG0750	zinc metalloprotease
DMI74_RS02280	COG1074	ATP-dependent DNA helicase activity
DMI74_RS02290	COG0697	spore germination
DMI74_RS02300	COG1002	Type II restriction enzyme, methylase subunits
DMI74_RS02305	COG1061	Type III restriction enzyme res subunit
DMI74_RS02310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMI74_RS02315	COG2373	Large extracellular alpha-helical protein
DMI74_RS02320	COG1979	alcohol dehydrogenase
DMI74_RS02330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMI74_RS02355	COG0372	Belongs to the citrate synthase family
DMI74_RS02370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMI74_RS02380	COG1187	pseudouridine synthase activity
DMI74_RS02390	COG0105	UTP biosynthetic process
DMI74_RS02395	COG1215	transferase activity, transferring glycosyl groups
DMI74_RS02400	COG0463	Glycosyl transferase, family 2
DMI74_RS02410	COG1459	type II secretion system
DMI74_RS02415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI74_RS02420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI74_RS02425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI74_RS02440	COG0728	peptidoglycan biosynthetic process
DMI74_RS02445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI74_RS02445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI74_RS02455	COG1649	PFAM Uncharacterised BCR, COG1649
DMI74_RS02460	COG1691	(AIR) carboxylase
DMI74_RS02465	COG0037	tRNA processing
DMI74_RS02470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMI74_RS02475	COG0142	geranyltranstransferase activity
DMI74_RS02490	COG2151	metal-sulfur cluster biosynthetic enzyme
DMI74_RS02510	COG1007	ATP synthesis coupled electron transport
DMI74_RS02515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI74_RS02525	COG0713	ATP synthesis coupled electron transport
DMI74_RS02530	COG0839	Belongs to the complex I subunit 6 family
DMI74_RS02540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DMI74_RS02545	COG1034	ATP synthesis coupled electron transport
DMI74_RS02550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMI74_RS02555	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DMI74_RS02560	COG0649	NAD binding
DMI74_RS02570	COG0726	polysaccharide deacetylase
DMI74_RS02580	COG0307	riboflavin synthase, alpha
DMI74_RS02585	COG2264	protein methyltransferase activity
DMI74_RS02590	COG3210	domain, Protein
DMI74_RS02595	COG1640	4-alpha-glucanotransferase
DMI74_RS02605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI74_RS02610	COG1030	water channel activity
DMI74_RS02615	COG0358	DNA primase activity
DMI74_RS02620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMI74_RS02625	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DMI74_RS02640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMI74_RS02645	COG0793	Belongs to the peptidase S41A family
DMI74_RS02660	COG1643	Atp-dependent helicase
DMI74_RS02685	COG1450	Type ii and iii secretion system protein
DMI74_RS02700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMI74_RS02720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI74_RS02725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMI74_RS02735	COG0268	Binds directly to 16S ribosomal RNA
DMI74_RS02740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI74_RS02745	COG0028	Belongs to the TPP enzyme family
DMI74_RS02755	COG0688	phosphatidylethanolamine metabolic process
DMI74_RS02760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMI74_RS02765	COG0495	leucyl-tRNA aminoacylation
DMI74_RS02770	COG3119	arylsulfatase activity
DMI74_RS02785	COG1166	arginine decarboxylase activity
DMI74_RS02795	COG3250	beta-galactosidase activity
DMI74_RS02800	COG3250	beta-galactosidase activity
DMI74_RS02805	COG3250	beta-galactosidase activity
DMI74_RS02810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMI74_RS02815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS02825	COG0205	6-phosphofructokinase activity
DMI74_RS02860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DMI74_RS02865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DMI74_RS02870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DMI74_RS02880	COG4771	TonB-dependent receptor
DMI74_RS02900	COG0402	S-adenosylhomocysteine deaminase activity
DMI74_RS02905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMI74_RS02925	COG1196	nuclear chromosome segregation
DMI74_RS02965	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI74_RS02975	COG1294	oxidase, subunit
DMI74_RS02980	COG1271	oxidase subunit
DMI74_RS02990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI74_RS03010	COG1846	Transcriptional regulator
DMI74_RS03040	COG2949	membrane
DMI74_RS03065	COG0514	ATP-dependent DNA helicase (RecQ)
DMI74_RS03080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMI74_RS03085	COG0045	succinate-CoA ligase (ADP-forming) activity
DMI74_RS03090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMI74_RS03150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI74_RS03155	COG2205	protein histidine kinase activity
DMI74_RS03170	COG0113	porphobilinogen synthase activity
DMI74_RS03180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMI74_RS03185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMI74_RS03200	COG0732	type I restriction modification DNA specificity domain
DMI74_RS03215	COG0732	type I restriction modification DNA specificity domain
DMI74_RS03225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMI74_RS03250	COG4106	trans-aconitate 2-methyltransferase activity
DMI74_RS03265	COG3475	LICD family
DMI74_RS03270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI74_RS03280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI74_RS03285	COG3475	LICD family
DMI74_RS03290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMI74_RS03300	COG2166	iron-sulfur cluster assembly
DMI74_RS03305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMI74_RS03315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI74_RS03320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMI74_RS03325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMI74_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMI74_RS03335	COG1131	(ABC) transporter
DMI74_RS03350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMI74_RS03365	COG1215	transferase activity, transferring glycosyl groups
DMI74_RS03375	COG2967	ApaG domain
DMI74_RS03385	COG1522	sequence-specific DNA binding
DMI74_RS03390	COG0436	Aminotransferase
DMI74_RS03405	COG0423	glycine-tRNA ligase activity
DMI74_RS03410	COG0656	L-ascorbic acid biosynthetic process
DMI74_RS03425	COG2304	oxidoreductase activity
DMI74_RS03440	COG0714	Associated with various cellular activities
DMI74_RS03445	COG0154	amidase activity
DMI74_RS03450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI74_RS03490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI74_RS03500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI74_RS03500	COG2755	lipolytic protein G-D-S-L family
DMI74_RS03520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI74_RS03530	COG0656	L-ascorbic acid biosynthetic process
DMI74_RS03540	COG0667	Aldo Keto reductase
DMI74_RS03545	COG1408	metallophosphoesterase
DMI74_RS03565	COG2249	NAD(P)H dehydrogenase (quinone) activity
DMI74_RS03570	COG0789	Transcriptional regulator
DMI74_RS03585	COG0534	Mate efflux family protein
DMI74_RS03605	COG1091	dTDP-4-dehydrorhamnose reductase activity
DMI74_RS03620	COG1837	Belongs to the UPF0109 family
DMI74_RS03625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI74_RS03630	COG0363	glucosamine-6-phosphate deaminase activity
DMI74_RS03650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DMI74_RS03660	COG1741	Belongs to the pirin family
DMI74_RS03675	COG1070	Carbohydrate kinase
DMI74_RS03690	COG0738	Major facilitator superfamily
DMI74_RS03705	COG1595	DNA-templated transcription, initiation
DMI74_RS03725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMI74_RS03745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI74_RS03760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DMI74_RS03765	COG2132	Multicopper oxidase
DMI74_RS03770	COG0697	spore germination
DMI74_RS03775	COG3586	endonuclease activity
DMI74_RS03785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI74_RS03790	COG4608	Belongs to the ABC transporter superfamily
DMI74_RS03795	COG0444	Belongs to the ABC transporter superfamily
DMI74_RS03800	COG4166	transmembrane transport
DMI74_RS03805	COG4239	(ABC) transporter, permease
DMI74_RS03810	COG0601	transmembrane transport
DMI74_RS03830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMI74_RS03835	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMI74_RS03840	COG3738	Protein conserved in bacteria
DMI74_RS03845	COG0151	Belongs to the GarS family
DMI74_RS03860	COG0811	peptide transport
DMI74_RS03870	COG0242	peptide deformylase activity
DMI74_RS03905	COG2010	Cytochrome c
DMI74_RS03915	COG3258	Cytochrome c
DMI74_RS03930	COG3274	enterobacterial common antigen metabolic process
DMI74_RS03935	COG0538	isocitrate dehydrogenase activity
DMI74_RS03950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI74_RS03955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMI74_RS03960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMI74_RS03970	COG0668	transmembrane transport
DMI74_RS03975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI74_RS03975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DMI74_RS03980	COG0805	protein transport
DMI74_RS03985	COG1968	undecaprenyl-diphosphatase activity
DMI74_RS04005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMI74_RS04020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMI74_RS04030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMI74_RS04040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI74_RS04050	COG1408	metallophosphoesterase
DMI74_RS04075	COG4974	Belongs to the 'phage' integrase family
DMI74_RS04095	COG1454	alcohol dehydrogenase
DMI74_RS04100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMI74_RS04110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMI74_RS04110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DMI74_RS04115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DMI74_RS04155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI74_RS04165	COG4607	ABC-type enterochelin transport system periplasmic component
DMI74_RS04170	COG4604	ABC transporter, ATP-binding protein
DMI74_RS04175	COG4605	iron ion homeostasis
DMI74_RS04180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMI74_RS04215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI74_RS04215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI74_RS04230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMI74_RS04235	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMI74_RS04255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI74_RS04275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI74_RS04300	COG0519	Catalyzes the synthesis of GMP from XMP
DMI74_RS04300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI74_RS04305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMI74_RS04335	COG1410	methionine synthase
DMI74_RS04335	COG0646	methionine synthase
DMI74_RS04340	COG2966	Psort location CytoplasmicMembrane, score
DMI74_RS04345	COG3610	response to peptide
DMI74_RS04355	COG0460	homoserine dehydrogenase
DMI74_RS04360	COG0527	aspartate kinase activity
DMI74_RS04370	COG5522	Integral membrane protein (intg_mem_TP0381)
DMI74_RS04380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMI74_RS04385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMI74_RS04390	COG1194	a g-specific adenine glycosylase
DMI74_RS04395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DMI74_RS04400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI74_RS04400	COG0574	Belongs to the PEP-utilizing enzyme family
DMI74_RS04405	COG0166	Belongs to the GPI family
DMI74_RS04415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI74_RS04440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI74_RS04440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI74_RS04475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMI74_RS04480	COG2818	Glycosylase
DMI74_RS04500	COG3033	Beta-eliminating lyase
DMI74_RS04515	COG0072	phenylalanine-tRNA ligase activity
DMI74_RS04515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI74_RS04530	COG3059	membrane
DMI74_RS04540	COG0326	Molecular chaperone. Has ATPase activity
DMI74_RS04565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI74_RS04570	COG1959	2 iron, 2 sulfur cluster binding
DMI74_RS04585	COG0352	thiamine-phosphate diphosphorylase activity
DMI74_RS04590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMI74_RS04605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS04615	COG1703	isobutyryl-CoA mutase activity
DMI74_RS04635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMI74_RS04645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI74_RS04650	COG0418	dihydroorotase activity
DMI74_RS04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI74_RS04685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMI74_RS04715	COG0534	Mate efflux family protein
DMI74_RS04720	COG0489	protein tyrosine kinase activity
DMI74_RS04730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI74_RS04740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI74_RS04750	COG1538	Outer membrane efflux protein
DMI74_RS04770	COG4112	unkown
DMI74_RS04785	COG0038	chloride channel
DMI74_RS04810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMI74_RS04820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI74_RS04825	COG0586	Pfam SNARE associated Golgi protein
DMI74_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
DMI74_RS04910	COG0753	catalase activity
DMI74_RS04920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI74_RS04925	COG1592	Rubrerythrin
DMI74_RS04930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMI74_RS04950	COG0489	protein tyrosine kinase activity
DMI74_RS04960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI74_RS04970	COG2244	polysaccharide biosynthetic process
DMI74_RS04975	COG1216	Glycosyl transferase, family 2
DMI74_RS04985	COG1216	Glycosyl transferase, family 2
DMI74_RS04995	COG0438	transferase activity, transferring glycosyl groups
DMI74_RS05000	COG0438	transferase activity, transferring glycosyl groups
DMI74_RS05030	COG1216	Glycosyl transferase, family 2
DMI74_RS05080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI74_RS05085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI74_RS05090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMI74_RS05100	COG0281	malic enzyme
DMI74_RS05100	COG0280	phosphate acetyltransferase
DMI74_RS05115	COG1472	Belongs to the glycosyl hydrolase 3 family
DMI74_RS05120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMI74_RS05135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMI74_RS05150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMI74_RS05155	COG1063	alcohol dehydrogenase
DMI74_RS05170	COG0714	Associated with various cellular activities
DMI74_RS05180	COG0193	aminoacyl-tRNA hydrolase activity
DMI74_RS05185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI74_RS05200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMI74_RS05225	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DMI74_RS05240	COG0375	protein maturation
DMI74_RS05265	COG0778	Nitroreductase
DMI74_RS05270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI74_RS05290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI74_RS05290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI74_RS05305	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI74_RS05305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI74_RS05325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS05330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMI74_RS05335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMI74_RS05395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI74_RS05400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI74_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
DMI74_RS05440	COG0339	signal peptide processing
DMI74_RS05450	COG0018	arginyl-trna synthetase
DMI74_RS05495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI74_RS05500	COG0653	protein targeting
DMI74_RS05515	COG0494	nUDIX hydrolase
DMI74_RS05520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI74_RS05525	COG1131	(ABC) transporter
DMI74_RS05545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMI74_RS05550	COG0564	pseudouridine synthase activity
DMI74_RS05565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMI74_RS05570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMI74_RS05580	COG0513	Belongs to the DEAD box helicase family
DMI74_RS05590	COG0673	inositol 2-dehydrogenase activity
DMI74_RS05610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DMI74_RS05625	COG1971	Probably functions as a manganese efflux pump
DMI74_RS05650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI74_RS05675	COG0442	prolyl-tRNA aminoacylation
DMI74_RS05705	COG0531	amino acid
DMI74_RS05710	COG2066	Belongs to the glutaminase family
DMI74_RS05720	COG1115	amino acid carrier protein
DMI74_RS05730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI74_RS05735	COG2890	protein-(glutamine-N5) methyltransferase activity
DMI74_RS05740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMI74_RS05745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMI74_RS05760	COG2226	methyltransferase
DMI74_RS05765	COG0534	Mate efflux family protein
DMI74_RS05825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI74_RS05830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMI74_RS05835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS05850	COG1121	(ABC) transporter
DMI74_RS05855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMI74_RS05860	COG3880	PFAM UvrB UvrC protein
DMI74_RS05865	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMI74_RS05870	COG0542	response to heat
DMI74_RS05885	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMI74_RS05890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI74_RS05905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI74_RS05905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMI74_RS05920	COG0180	Tryptophanyl-tRNA synthetase
DMI74_RS05930	COG1692	metallophosphoesterase
DMI74_RS05935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMI74_RS05950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMI74_RS05955	COG2816	NAD+ diphosphatase activity
DMI74_RS05960	COG0156	8-amino-7-oxononanoate synthase activity
DMI74_RS05975	COG0515	serine threonine protein kinase
DMI74_RS05975	COG3266	domain, Protein
DMI74_RS06165	COG1598	PFAM Uncharacterised protein family UPF0150
DMI74_RS06230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMI74_RS06250	COG0732	type I restriction modification DNA specificity domain
DMI74_RS06255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMI74_RS06260	COG3189	MarR family transcriptional regulator
DMI74_RS06270	COG0181	hydroxymethylbilane synthase activity
DMI74_RS06275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMI74_RS06285	COG1469	GTP cyclohydrolase I activity
DMI74_RS06290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMI74_RS06295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMI74_RS06305	COG1940	carbohydrate kinase activity
DMI74_RS06320	COG0494	nUDIX hydrolase
DMI74_RS06325	COG1566	PFAM secretion protein HlyD family protein
DMI74_RS06330	COG1136	(ABC) transporter
DMI74_RS06330	COG0577	efflux transmembrane transporter activity
DMI74_RS06335	COG0577	efflux transmembrane transporter activity
DMI74_RS06335	COG1136	(ABC) transporter
DMI74_RS06340	COG1538	Outer membrane efflux protein
DMI74_RS06355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI74_RS06365	COG1720	tRNA m6t6A37 methyltransferase activity
DMI74_RS06370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMI74_RS06375	COG0540	Belongs to the ATCase OTCase family
DMI74_RS06380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMI74_RS06395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DMI74_RS06400	COG2957	Belongs to the agmatine deiminase family
DMI74_RS06410	COG0750	zinc metalloprotease
DMI74_RS06420	COG3119	arylsulfatase activity
DMI74_RS06430	COG1918	ferrous iron import across plasma membrane
DMI74_RS06430	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI74_RS06480	COG1475	DNA binding
DMI74_RS06515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMI74_RS06525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMI74_RS06530	COG0601	transmembrane transport
DMI74_RS06585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMI74_RS06590	COG1132	(ABC) transporter
DMI74_RS06595	COG1132	(ABC) transporter
DMI74_RS06610	COG1127	ABC transporter
DMI74_RS06615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DMI74_RS06645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMI74_RS06660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DMI74_RS06665	COG0504	CTP synthase activity
DMI74_RS06670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMI74_RS06695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI74_RS06705	COG1322	Protein conserved in bacteria
DMI74_RS06710	COG0546	phosphoglycolate phosphatase activity
DMI74_RS06715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI74_RS06725	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI74_RS06755	COG2755	lipolytic protein G-D-S-L family
DMI74_RS06755	COG0657	acetylesterase activity
DMI74_RS06760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMI74_RS06780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMI74_RS06800	COG0335	large ribosomal subunit rRNA binding
DMI74_RS06810	COG0346	lactoylglutathione lyase activity
DMI74_RS06825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMI74_RS06830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DMI74_RS06835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DMI74_RS06835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DMI74_RS06840	COG0427	acetyl-CoA hydrolase
DMI74_RS06850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DMI74_RS06860	COG0205	6-phosphofructokinase activity
DMI74_RS06870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI74_RS06875	COG0028	Belongs to the TPP enzyme family
DMI74_RS06895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DMI74_RS06910	COG0471	metal ion transport
DMI74_RS06920	COG0351	phosphomethylpyrimidine kinase
DMI74_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
DMI74_RS06990	COG0242	peptide deformylase activity
DMI74_RS06995	COG1063	alcohol dehydrogenase
DMI74_RS07005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMI74_RS07010	COG1393	Belongs to the ArsC family
DMI74_RS07015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI74_RS07020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMI74_RS07030	COG1187	pseudouridine synthase activity
DMI74_RS07040	COG0336	Belongs to the RNA methyltransferase TrmD family
DMI74_RS07055	COG0539	negative regulation of cytoplasmic translation
DMI74_RS07100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMI74_RS07105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMI74_RS07110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMI74_RS07115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI74_RS07155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI74_RS07175	COG0662	Cupin 2, conserved barrel domain protein
DMI74_RS07175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMI74_RS07185	COG0416	fatty acid biosynthetic process
DMI74_RS07190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMI74_RS07200	COG0537	adenosine 5'-monophosphoramidase activity
DMI74_RS07205	COG0009	L-threonylcarbamoyladenylate synthase
DMI74_RS07210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMI74_RS07215	COG0228	four-way junction DNA binding
DMI74_RS07235	COG1862	Preprotein translocase
DMI74_RS07240	COG0343	queuine tRNA-ribosyltransferase activity
DMI74_RS07245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMI74_RS07255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DMI74_RS07260	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMI74_RS07265	COG0776	regulation of translation
DMI74_RS07295	COG0811	peptide transport
DMI74_RS07310	COG3250	beta-galactosidase activity
DMI74_RS07315	COG0525	valine-tRNA ligase activity
DMI74_RS07330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMI74_RS07335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMI74_RS07340	COG0255	Belongs to the universal ribosomal protein uL29 family
DMI74_RS07345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMI74_RS07350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMI74_RS07355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMI74_RS07365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMI74_RS07370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMI74_RS07375	COG0089	rRNA binding
DMI74_RS07380	COG0088	Forms part of the polypeptide exit tunnel
DMI74_RS07385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMI74_RS07390	COG0051	transcription antitermination factor activity, RNA binding
DMI74_RS07395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMI74_RS07400	COG0049	tRNA binding
DMI74_RS07405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMI74_RS07410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMI74_RS07420	COG3852	Histidine kinase
DMI74_RS07425	COG2204	response regulator
DMI74_RS07435	COG1722	exodeoxyribonuclease VII activity
DMI74_RS07440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI74_RS07455	COG0795	lipopolysaccharide-transporting ATPase activity
DMI74_RS07460	COG1160	GTP binding
DMI74_RS07465	COG0444	Belongs to the ABC transporter superfamily
DMI74_RS07485	COG1136	(ABC) transporter
DMI74_RS07485	COG0577	efflux transmembrane transporter activity
DMI74_RS07495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI74_RS07540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMI74_RS07545	COG0799	negative regulation of ribosome biogenesis
DMI74_RS07550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMI74_RS07600	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DMI74_RS07615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DMI74_RS07625	COG0300	oxidoreductase activity
DMI74_RS07645	COG0038	chloride channel
DMI74_RS07655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS07670	COG0076	glutamate decarboxylase activity
DMI74_RS07685	COG0167	dihydroorotate dehydrogenase activity
DMI74_RS07690	COG0352	thiamine-phosphate diphosphorylase activity
DMI74_RS07710	COG1253	flavin adenine dinucleotide binding
DMI74_RS07715	COG1253	flavin adenine dinucleotide binding
DMI74_RS07720	COG1185	polyribonucleotide nucleotidyltransferase activity
DMI74_RS07725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMI74_RS07730	COG0110	maltose O-acetyltransferase activity
DMI74_RS07755	COG0101	tRNA pseudouridine synthase activity
DMI74_RS07760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMI74_RS07775	COG4968	Prepilin-type N-terminal cleavage methylation domain
DMI74_RS07790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS07795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMI74_RS07815	COG1136	(ABC) transporter
DMI74_RS07820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMI74_RS07830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI74_RS07855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS07860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DMI74_RS07865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DMI74_RS07875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMI74_RS07880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMI74_RS07900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI74_RS07905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI74_RS07905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI74_RS07910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMI74_RS07915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMI74_RS07920	COG0552	protein localization to endoplasmic reticulum
DMI74_RS07925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMI74_RS07945	COG1546	Belongs to the CinA family
DMI74_RS07945	COG1058	Belongs to the CinA family
DMI74_RS07955	COG0456	acetyltransferase
DMI74_RS07980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMI74_RS07985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMI74_RS07990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMI74_RS07995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI74_RS08010	COG0758	DNA mediated transformation
DMI74_RS08015	COG1686	Belongs to the peptidase S11 family
DMI74_RS08020	COG0012	GTP binding
DMI74_RS08025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMI74_RS08035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI74_RS08035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI74_RS08050	COG3119	arylsulfatase activity
DMI74_RS08075	COG2259	Doxx family
DMI74_RS08080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMI74_RS08110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI74_RS08130	COG2326	polyphosphate kinase activity
DMI74_RS08135	COG1349	DNA-binding transcription factor activity
DMI74_RS08150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI74_RS08155	COG1162	GTPase activity
DMI74_RS08170	COG0742	ribosomal rna small subunit methyltransferase
DMI74_RS08185	COG2326	polyphosphate kinase activity
DMI74_RS08195	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI74_RS08205	COG1073	alpha beta
DMI74_RS08210	COG0802	atpase or kinase
DMI74_RS08215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMI74_RS08220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMI74_RS08225	COG0735	belongs to the Fur family
DMI74_RS08230	COG0396	ATPase activity
DMI74_RS08235	COG0719	Fe-S assembly protein
DMI74_RS08240	COG0719	Fe-S assembly protein
DMI74_RS08255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMI74_RS08295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI74_RS08315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMI74_RS08320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMI74_RS08325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMI74_RS08330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMI74_RS08335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMI74_RS08340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMI74_RS08350	COG0356	it plays a direct role in the translocation of protons across the membrane
DMI74_RS08400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMI74_RS08425	COG1045	serine acetyltransferase
DMI74_RS08430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMI74_RS08435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMI74_RS08440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMI74_RS08450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMI74_RS08460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMI74_RS08465	COG0047	phosphoribosylformylglycinamidine synthase activity
DMI74_RS08475	COG1363	Peptidase, m42
DMI74_RS08490	COG1077	Cell shape determining protein MreB Mrl
DMI74_RS08495	COG1530	ribonuclease E activity
DMI74_RS08515	COG0848	biopolymer transport protein
DMI74_RS08535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMI74_RS08550	COG0134	indole-3-glycerol-phosphate synthase activity
DMI74_RS08555	COG0792	nuclease activity
DMI74_RS08565	COG1253	flavin adenine dinucleotide binding
DMI74_RS08575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMI74_RS08580	COG0137	argininosuccinate synthase activity
DMI74_RS08595	COG0149	triose-phosphate isomerase activity
DMI74_RS08630	COG1040	competence protein
DMI74_RS08640	COG3956	TIGRFAM MazG family protein
DMI74_RS08660	COG1663	tetraacyldisaccharide 4'-kinase activity
DMI74_RS08670	COG0612	Peptidase, M16
DMI74_RS08685	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI74_RS08690	COG0583	DNA-binding transcription factor activity
DMI74_RS08715	COG0673	inositol 2-dehydrogenase activity
DMI74_RS08720	COG3034	peptidoglycan biosynthetic process
DMI74_RS08740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMI74_RS08745	COG0424	maF-like protein
DMI74_RS08750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMI74_RS08755	COG2815	serine threonine protein kinase
DMI74_RS08755	COG0515	serine threonine protein kinase
DMI74_RS08780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMI74_RS08790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMI74_RS08800	COG0571	ribonuclease III activity
DMI74_RS08820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMI74_RS08835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMI74_RS08855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI74_RS08870	COG2226	methyltransferase
DMI74_RS08880	COG2076	Multidrug Resistance protein
DMI74_RS09110	COG2255	four-way junction helicase activity
DMI74_RS09115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMI74_RS09120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI74_RS09125	COG1215	transferase activity, transferring glycosyl groups
DMI74_RS09130	COG1216	Glycosyl transferase, family 2
DMI74_RS09130	COG0463	Glycosyl transferase, family 2
DMI74_RS09155	COG0438	transferase activity, transferring glycosyl groups
DMI74_RS09165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI74_RS09175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMI74_RS09185	COG0482	sulfurtransferase activity
DMI74_RS09190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMI74_RS09200	COG2860	membrane
DMI74_RS09205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI74_RS09210	COG2001	Belongs to the MraZ family
DMI74_RS09215	COG0275	rRNA processing
DMI74_RS09225	COG0768	penicillin binding
DMI74_RS09230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMI74_RS09235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMI74_RS09240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMI74_RS09245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMI74_RS09255	COG0772	Belongs to the SEDS family
DMI74_RS09260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI74_RS09265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI74_RS09270	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI74_RS09280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMI74_RS09285	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI74_RS09290	COG0321	lipoyl(octanoyl) transferase activity
DMI74_RS09295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMI74_RS09300	COG0066	3-isopropylmalate dehydratase activity
DMI74_RS09310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI74_RS09320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI74_RS09325	COG4608	Belongs to the ABC transporter superfamily
DMI74_RS09330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMI74_RS09335	COG0052	Belongs to the universal ribosomal protein uS2 family
DMI74_RS09345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DMI74_RS09360	COG1137	ATPase activity
DMI74_RS09370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI74_RS09395	COG0017	Asparaginyl-tRNA synthetase
DMI74_RS09405	COG3118	belongs to the thioredoxin family
DMI74_RS09455	COG0583	DNA-binding transcription factor activity
DMI74_RS09460	COG2855	membrane
DMI74_RS09465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI74_RS09475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMI74_RS09485	COG0602	queuosine metabolic process
DMI74_RS09490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI74_RS09495	COG0217	transcriptional regulatory protein
DMI74_RS09500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMI74_RS09505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI74_RS09505	COG4651	solute:proton antiporter activity
DMI74_RS09515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMI74_RS09520	COG4864	UPF0365 protein
DMI74_RS09530	COG2022	thiamine diphosphate biosynthetic process
DMI74_RS09535	COG0531	amino acid
DMI74_RS09545	COG0628	permease
DMI74_RS09550	COG0019	diaminopimelate decarboxylase activity
DMI74_RS09555	COG0191	fructose-bisphosphate aldolase activity
DMI74_RS09560	COG1217	gtp-binding protein TYPA
DMI74_RS09590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMI74_RS09620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI74_RS09625	COG0516	GMP reductase activity
DMI74_RS09625	COG0517	IMP dehydrogenase activity
DMI74_RS09630	COG0519	Catalyzes the synthesis of GMP from XMP
DMI74_RS09630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI74_RS09640	COG0546	phosphoglycolate phosphatase activity
DMI74_RS09660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMI74_RS09675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMI74_RS09680	COG0196	riboflavin kinase activity
DMI74_RS09685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMI74_RS09700	COG1408	metallophosphoesterase
DMI74_RS09710	COG1216	Glycosyl transferase, family 2
DMI74_RS09710	COG1442	glycosyl transferase family 8
DMI74_RS09720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI74_RS09725	COG1216	Glycosyl transferase, family 2
DMI74_RS09745	COG2755	lipolytic protein G-D-S-L family
DMI74_RS09745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI74_RS09760	COG0471	metal ion transport
DMI74_RS09760	COG0490	domain, Protein
DMI74_RS09795	COG0588	phosphoglycerate mutase activity
DMI74_RS09800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMI74_RS09810	COG0477	Major facilitator Superfamily
DMI74_RS09815	COG1607	acyl-coa hydrolase
DMI74_RS09830	COG1525	nuclease
DMI74_RS09845	COG1475	DNA binding
DMI74_RS09850	COG3969	phosphoadenosine phosphosulfate
DMI74_RS09935	COG3015	lipoprotein NlpE involved in copper resistance
DMI74_RS10005	COG0305	Participates in initiation and elongation during chromosome replication
DMI74_RS10100	COG0473	3-isopropylmalate dehydrogenase activity
DMI74_RS10125	COG2873	o-acetylhomoserine
DMI74_RS10130	COG0535	radical SAM domain protein
DMI74_RS10135	COG0535	radical SAM domain protein
DMI74_RS10150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI74_RS10155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMI74_RS10165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMI74_RS10175	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMI74_RS10175	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMI74_RS10175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DMI74_RS10175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMI74_RS10185	COG1733	regulation of RNA biosynthetic process
DMI74_RS10195	COG0107	imidazoleglycerol-phosphate synthase activity
DMI74_RS10205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI74_RS10215	COG1643	Atp-dependent helicase
DMI74_RS10220	COG0440	acetolactate synthase activity
DMI74_RS10225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI74_RS10235	COG0445	tRNA wobble uridine modification
DMI74_RS10240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI74_RS10240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI74_RS10245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMI74_RS10255	COG0592	DNA-directed DNA polymerase activity
DMI74_RS10280	COG0791	NLP P60 protein
DMI74_RS10280	COG1388	LysM domain
DMI74_RS10285	COG0084	hydrolase, TatD family'
DMI74_RS10295	COG3250	beta-galactosidase activity
DMI74_RS10310	COG2205	protein histidine kinase activity
DMI74_RS10315	COG0745	RESPONSE REGULATOR receiver
DMI74_RS10325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI74_RS10335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI74_RS10355	COG0542	response to heat
DMI74_RS10400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMI74_RS10410	COG0659	secondary active sulfate transmembrane transporter activity
DMI74_RS10415	COG0165	Argininosuccinate lyase
DMI74_RS10430	COG0148	phosphopyruvate hydratase activity
DMI74_RS10435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMI74_RS10445	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMI74_RS10455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI74_RS10460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMI74_RS10510	COG2985	domain, Protein
DMI74_RS10510	COG0490	domain, Protein
DMI74_RS10525	COG0471	metal ion transport
DMI74_RS10550	COG2194	sulfuric ester hydrolase activity
DMI74_RS10555	COG1592	Rubrerythrin
DMI74_RS10565	COG1363	Peptidase, m42
DMI74_RS10570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI74_RS10580	COG1785	Belongs to the alkaline phosphatase family
DMI74_RS10585	COG1970	mechanosensitive ion channel activity
DMI74_RS10590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMI74_RS10600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMI74_RS10610	COG2217	Heavy metal translocating P-type atpase
DMI74_RS10615	COG0497	DNA recombination
DMI74_RS10620	COG0321	lipoyl(octanoyl) transferase activity
DMI74_RS10620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI74_RS10625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMI74_RS10655	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI74_RS10660	COG0022	dehydrogenase e1 component
DMI74_RS10665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI74_RS10670	COG0789	Transcriptional regulator
DMI74_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI74_RS10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI74_RS10685	COG3210	domain, Protein
DMI74_RS10735	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI74_RS10735	COG3409	Peptidoglycan-binding domain 1 protein
DMI74_RS10740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMI74_RS10765	COG1690	Belongs to the RtcB family
DMI74_RS10775	COG2814	Major facilitator Superfamily
DMI74_RS10785	COG2096	Adenosyltransferase
DMI74_RS10795	COG0557	exoribonuclease II activity
DMI74_RS10810	COG0826	peptidase U32
DMI74_RS10815	COG0285	dihydrofolate synthase activity
DMI74_RS10830	COG0673	inositol 2-dehydrogenase activity
DMI74_RS10835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI74_RS10840	COG0737	Belongs to the 5'-nucleotidase family
DMI74_RS10850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI74_RS10855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMI74_RS10870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMI74_RS10875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMI74_RS10880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMI74_RS10885	COG0200	Binds to the 23S rRNA
DMI74_RS10890	COG0201	protein transport
DMI74_RS10895	COG0563	adenylate kinase activity
DMI74_RS10900	COG0024	Methionine aminopeptidase
DMI74_RS10915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMI74_RS10920	COG1442	glycosyl transferase family 8
DMI74_RS10930	COG1216	Glycosyl transferase, family 2
DMI74_RS10940	COG1216	Glycosyl transferase, family 2
DMI74_RS10955	COG1216	Glycosyl transferase, family 2
DMI74_RS10960	COG0693	protein deglycase activity
DMI74_RS10965	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI74_RS10970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMI74_RS10975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI74_RS10985	COG1966	Carbon starvation protein
DMI74_RS11000	COG3119	arylsulfatase activity
DMI74_RS11010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMI74_RS11015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMI74_RS11020	COG0195	Participates in both transcription termination and antitermination
DMI74_RS11025	COG0708	Exodeoxyribonuclease III
DMI74_RS11030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMI74_RS11035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMI74_RS11040	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DMI74_RS11050	COG1131	(ABC) transporter
DMI74_RS11050	COG0842	Transport permease protein
DMI74_RS11050	COG1716	ATPase activity
DMI74_RS11070	COG0724	RNA recognition motif
DMI74_RS11075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI74_RS11095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMI74_RS11105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DMI74_RS11110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMI74_RS11125	COG1490	D-aminoacyl-tRNA deacylase activity
DMI74_RS11140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMI74_RS11145	COG1053	succinate dehydrogenase
DMI74_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
DMI74_RS11200	COG0488	(ABC) transporter
DMI74_RS11210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMI74_RS11220	COG1253	flavin adenine dinucleotide binding
DMI74_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
DMI74_RS11235	COG1073	alpha beta
DMI74_RS11245	COG0667	Aldo Keto reductase
DMI74_RS11300	COG2267	carboxylic ester hydrolase activity
DMI74_RS11305	COG2095	MarC family integral membrane protein
DMI74_RS11345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI74_RS11350	COG0488	(ABC) transporter
DMI74_RS11360	COG0697	spore germination
DMI74_RS11370	COG0215	cysteine-tRNA ligase activity
DMI74_RS11380	COG3119	arylsulfatase activity
DMI74_RS11395	COG0481	GTPase activity
DMI74_RS11410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMI74_RS11415	COG0085	RNA polymerase activity
DMI74_RS11420	COG0222	ribosome binding
DMI74_RS11425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMI74_RS11430	COG0081	regulation of translation
DMI74_RS11435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMI74_RS11440	COG0250	Participates in transcription elongation, termination and antitermination
DMI74_RS11455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMI74_RS11475	COG0740	serine-type endopeptidase activity
DMI74_RS11480	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMI74_RS11495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMI74_RS11515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI74_RS11555	COG2226	methyltransferase
DMI74_RS11560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMI74_RS11565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMI74_RS11580	COG1902	pentaerythritol trinitrate reductase activity
DMI74_RS11580	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMI74_RS11590	COG3119	arylsulfatase activity
DMI74_RS11595	COG0514	ATP-dependent DNA helicase (RecQ)
DMI74_RS11615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMI74_RS11620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMI74_RS11675	COG1858	cytochrome C peroxidase
DMI74_RS11680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMI74_RS11685	COG0590	tRNA wobble adenosine to inosine editing
DMI74_RS11690	COG1940	carbohydrate kinase activity
DMI74_RS11695	COG2217	Heavy metal translocating P-type atpase
DMI74_RS11700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI74_RS11705	COG0237	dephospho-CoA kinase activity
DMI74_RS11735	COG1363	Peptidase, m42
DMI74_RS11740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMI74_RS11750	COG0006	proline dipeptidase activity
DMI74_RS11755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMI74_RS11765	COG5002	protein histidine kinase activity
DMI74_RS11770	COG0745	RESPONSE REGULATOR receiver
DMI74_RS11775	COG0129	dihydroxy-acid dehydratase activity
DMI74_RS11800	COG1368	sulfuric ester hydrolase activity
DMI74_RS11835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI74_RS11840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMI74_RS11860	COG0534	Mate efflux family protein
DMI74_RS11865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI74_RS11880	COG1876	peptidase activity
DMI74_RS11940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI74_RS11945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI74_RS11990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DMI74_RS12005	COG2814	Major facilitator Superfamily