locus-tag	class	description
C5N96_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5N96_RS00010	COG1131	(ABC) transporter
C5N96_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5N96_RS00035	COG0564	pseudouridine synthase activity
C5N96_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5N96_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5N96_RS00065	COG0513	Belongs to the DEAD box helicase family
C5N96_RS00075	COG0673	inositol 2-dehydrogenase activity
C5N96_RS00110	COG1971	Probably functions as a manganese efflux pump
C5N96_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5N96_RS00160	COG0442	prolyl-tRNA aminoacylation
C5N96_RS00175	COG2963	transposase activity
C5N96_RS00210	COG0531	amino acid
C5N96_RS00215	COG2066	Belongs to the glutaminase family
C5N96_RS00225	COG1115	amino acid carrier protein
C5N96_RS00235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5N96_RS00240	COG2890	protein-(glutamine-N5) methyltransferase activity
C5N96_RS00245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5N96_RS00250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5N96_RS00265	COG2226	methyltransferase
C5N96_RS00270	COG0534	Mate efflux family protein
C5N96_RS00315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5N96_RS00320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS00340	COG1121	(ABC) transporter
C5N96_RS00345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5N96_RS00350	COG3880	PFAM UvrB UvrC protein
C5N96_RS00355	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5N96_RS00360	COG0542	response to heat
C5N96_RS00370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5N96_RS00375	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5N96_RS00380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5N96_RS00395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5N96_RS00395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5N96_RS00405	COG0180	Tryptophanyl-tRNA synthetase
C5N96_RS00415	COG1692	metallophosphoesterase
C5N96_RS00420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5N96_RS00480	COG0515	serine threonine protein kinase
C5N96_RS00575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5N96_RS00580	COG2816	NAD+ diphosphatase activity
C5N96_RS00585	COG0156	8-amino-7-oxononanoate synthase activity
C5N96_RS00600	COG0515	serine threonine protein kinase
C5N96_RS00600	COG3266	domain, Protein
C5N96_RS00640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5N96_RS00660	COG0732	type I restriction modification DNA specificity domain
C5N96_RS00665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5N96_RS00670	COG3189	MarR family transcriptional regulator
C5N96_RS00680	COG0181	hydroxymethylbilane synthase activity
C5N96_RS00685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5N96_RS00695	COG1469	GTP cyclohydrolase I activity
C5N96_RS00700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5N96_RS00705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5N96_RS00715	COG1940	carbohydrate kinase activity
C5N96_RS00730	COG0494	nUDIX hydrolase
C5N96_RS00735	COG1566	PFAM secretion protein HlyD family protein
C5N96_RS00740	COG1136	(ABC) transporter
C5N96_RS00740	COG0577	efflux transmembrane transporter activity
C5N96_RS00745	COG1136	(ABC) transporter
C5N96_RS00745	COG0577	efflux transmembrane transporter activity
C5N96_RS00750	COG1538	Outer membrane efflux protein
C5N96_RS00765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5N96_RS00805	COG1720	tRNA m6t6A37 methyltransferase activity
C5N96_RS00810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5N96_RS00815	COG0540	Belongs to the ATCase OTCase family
C5N96_RS00820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5N96_RS00835	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C5N96_RS00840	COG2957	Belongs to the agmatine deiminase family
C5N96_RS00850	COG0750	zinc metalloprotease
C5N96_RS00860	COG3119	arylsulfatase activity
C5N96_RS00870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5N96_RS00870	COG1918	ferrous iron import across plasma membrane
C5N96_RS00930	COG1475	DNA binding
C5N96_RS00965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5N96_RS00980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5N96_RS00985	COG0601	transmembrane transport
C5N96_RS01035	COG0849	cell division
C5N96_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5N96_RS01050	COG1132	(ABC) transporter
C5N96_RS01055	COG1132	(ABC) transporter
C5N96_RS01070	COG1127	ABC transporter
C5N96_RS01075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5N96_RS01105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5N96_RS01120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5N96_RS01125	COG0504	CTP synthase activity
C5N96_RS01130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5N96_RS01155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N96_RS01165	COG1322	Protein conserved in bacteria
C5N96_RS01170	COG0546	phosphoglycolate phosphatase activity
C5N96_RS01175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5N96_RS01185	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5N96_RS01185	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5N96_RS01190	COG3209	COG3209 Rhs family protein
C5N96_RS01230	COG2234	aminopeptidase activity
C5N96_RS01235	COG0657	acetylesterase activity
C5N96_RS01235	COG2755	lipolytic protein G-D-S-L family
C5N96_RS01240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5N96_RS01260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5N96_RS01280	COG0335	large ribosomal subunit rRNA binding
C5N96_RS01290	COG0346	lactoylglutathione lyase activity
C5N96_RS01305	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5N96_RS01310	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C5N96_RS01320	COG0427	acetyl-CoA hydrolase
C5N96_RS01335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5N96_RS01345	COG0205	6-phosphofructokinase activity
C5N96_RS01355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5N96_RS01360	COG0028	Belongs to the TPP enzyme family
C5N96_RS01380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5N96_RS01395	COG0471	metal ion transport
C5N96_RS01405	COG0351	phosphomethylpyrimidine kinase
C5N96_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
C5N96_RS01465	COG0242	peptide deformylase activity
C5N96_RS01470	COG1063	alcohol dehydrogenase
C5N96_RS01480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5N96_RS01485	COG1393	Belongs to the ArsC family
C5N96_RS01490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5N96_RS01500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5N96_RS01510	COG1187	pseudouridine synthase activity
C5N96_RS01520	COG0336	Belongs to the RNA methyltransferase TrmD family
C5N96_RS01535	COG0539	negative regulation of cytoplasmic translation
C5N96_RS01580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5N96_RS01585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5N96_RS01590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5N96_RS01595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5N96_RS01630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5N96_RS01710	COG3015	lipoprotein NlpE involved in copper resistance
C5N96_RS01785	COG0305	Participates in initiation and elongation during chromosome replication
C5N96_RS01880	COG0662	Cupin 2, conserved barrel domain protein
C5N96_RS01880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5N96_RS01890	COG0416	fatty acid biosynthetic process
C5N96_RS01895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5N96_RS01905	COG0537	adenosine 5'-monophosphoramidase activity
C5N96_RS01910	COG0009	L-threonylcarbamoyladenylate synthase
C5N96_RS01915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5N96_RS01920	COG0228	four-way junction DNA binding
C5N96_RS01950	COG1862	Preprotein translocase
C5N96_RS01955	COG0343	queuine tRNA-ribosyltransferase activity
C5N96_RS01960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5N96_RS01970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5N96_RS01975	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5N96_RS01980	COG0776	regulation of translation
C5N96_RS02010	COG0811	peptide transport
C5N96_RS02025	COG3250	beta-galactosidase activity
C5N96_RS02040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5N96_RS02045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5N96_RS02050	COG0255	Belongs to the universal ribosomal protein uL29 family
C5N96_RS02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5N96_RS02060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5N96_RS02065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5N96_RS02075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5N96_RS02080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5N96_RS02085	COG0089	rRNA binding
C5N96_RS02090	COG0088	Forms part of the polypeptide exit tunnel
C5N96_RS02095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5N96_RS02100	COG0051	transcription antitermination factor activity, RNA binding
C5N96_RS02105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5N96_RS02110	COG0049	tRNA binding
C5N96_RS02115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5N96_RS02120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5N96_RS02130	COG3852	Histidine kinase
C5N96_RS02135	COG2204	response regulator
C5N96_RS02145	COG1722	exodeoxyribonuclease VII activity
C5N96_RS02150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5N96_RS02165	COG0795	lipopolysaccharide-transporting ATPase activity
C5N96_RS02170	COG1160	GTP binding
C5N96_RS02175	COG0444	Belongs to the ABC transporter superfamily
C5N96_RS02190	COG1136	(ABC) transporter
C5N96_RS02190	COG0577	efflux transmembrane transporter activity
C5N96_RS02200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5N96_RS02245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5N96_RS02250	COG0799	negative regulation of ribosome biogenesis
C5N96_RS02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5N96_RS02305	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C5N96_RS02320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5N96_RS02330	COG4221	oxidoreductase activity
C5N96_RS02355	COG0038	chloride channel
C5N96_RS02365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS02380	COG0076	glutamate decarboxylase activity
C5N96_RS02395	COG0167	dihydroorotate dehydrogenase activity
C5N96_RS02400	COG0352	thiamine-phosphate diphosphorylase activity
C5N96_RS02420	COG1253	flavin adenine dinucleotide binding
C5N96_RS02425	COG1253	flavin adenine dinucleotide binding
C5N96_RS02430	COG1185	polyribonucleotide nucleotidyltransferase activity
C5N96_RS02435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5N96_RS02465	COG0101	tRNA pseudouridine synthase activity
C5N96_RS02470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5N96_RS02485	COG4968	Prepilin-type N-terminal cleavage methylation domain
C5N96_RS02500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS02505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5N96_RS02525	COG1136	(ABC) transporter
C5N96_RS02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5N96_RS02540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5N96_RS02565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS02570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5N96_RS02575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5N96_RS02585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5N96_RS02590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5N96_RS02600	COG2814	Major facilitator Superfamily
C5N96_RS02610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5N96_RS02615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5N96_RS02615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5N96_RS02620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5N96_RS02625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5N96_RS02630	COG0552	protein localization to endoplasmic reticulum
C5N96_RS02635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5N96_RS02655	COG1058	Belongs to the CinA family
C5N96_RS02655	COG1546	Belongs to the CinA family
C5N96_RS02665	COG0456	acetyltransferase
C5N96_RS02690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5N96_RS02695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5N96_RS02700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5N96_RS02705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5N96_RS02720	COG0758	DNA mediated transformation
C5N96_RS02725	COG1686	Belongs to the peptidase S11 family
C5N96_RS02730	COG0012	GTP binding
C5N96_RS02735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5N96_RS02745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5N96_RS02745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5N96_RS02765	COG3119	arylsulfatase activity
C5N96_RS02790	COG2259	Doxx family
C5N96_RS02795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5N96_RS02825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5N96_RS02845	COG2326	polyphosphate kinase activity
C5N96_RS02850	COG1349	DNA-binding transcription factor activity
C5N96_RS02875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5N96_RS02880	COG1162	GTPase activity
C5N96_RS02895	COG0742	ribosomal rna small subunit methyltransferase
C5N96_RS02910	COG2326	polyphosphate kinase activity
C5N96_RS02920	COG5434	Belongs to the glycosyl hydrolase 28 family
C5N96_RS02930	COG1073	alpha beta
C5N96_RS02935	COG0802	atpase or kinase
C5N96_RS02940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5N96_RS02945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5N96_RS02950	COG0735	belongs to the Fur family
C5N96_RS02955	COG0396	ATPase activity
C5N96_RS02960	COG0719	Fe-S assembly protein
C5N96_RS02965	COG0719	Fe-S assembly protein
C5N96_RS02980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5N96_RS03025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5N96_RS03045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5N96_RS03050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5N96_RS03055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5N96_RS03060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5N96_RS03065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5N96_RS03070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5N96_RS03080	COG0356	it plays a direct role in the translocation of protons across the membrane
C5N96_RS03130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5N96_RS03165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5N96_RS03170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5N96_RS03175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5N96_RS03185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5N96_RS03195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5N96_RS03200	COG0047	phosphoribosylformylglycinamidine synthase activity
C5N96_RS03210	COG1363	Peptidase, m42
C5N96_RS03225	COG1077	Cell shape determining protein MreB Mrl
C5N96_RS03230	COG1530	ribonuclease E activity
C5N96_RS03250	COG0848	biopolymer transport protein
C5N96_RS03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5N96_RS03280	COG0134	indole-3-glycerol-phosphate synthase activity
C5N96_RS03285	COG0792	nuclease activity
C5N96_RS03295	COG1253	flavin adenine dinucleotide binding
C5N96_RS03305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5N96_RS03310	COG0137	argininosuccinate synthase activity
C5N96_RS03325	COG0149	triose-phosphate isomerase activity
C5N96_RS03360	COG1040	competence protein
C5N96_RS03370	COG3956	TIGRFAM MazG family protein
C5N96_RS03390	COG1663	tetraacyldisaccharide 4'-kinase activity
C5N96_RS03400	COG0612	Peptidase, M16
C5N96_RS03415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5N96_RS03445	COG0673	inositol 2-dehydrogenase activity
C5N96_RS03450	COG3034	peptidoglycan biosynthetic process
C5N96_RS03470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5N96_RS03475	COG0424	maF-like protein
C5N96_RS03480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5N96_RS03510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5N96_RS03520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5N96_RS03530	COG0571	ribonuclease III activity
C5N96_RS03550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5N96_RS03565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5N96_RS03585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5N96_RS03595	COG2226	methyltransferase
C5N96_RS03635	COG2801	Transposase and inactivated derivatives
C5N96_RS03645	COG4115	mRNA cleavage
C5N96_RS03650	COG2161	toxin-antitoxin pair type II binding
C5N96_RS03660	COG2255	four-way junction helicase activity
C5N96_RS03665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5N96_RS03670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5N96_RS03675	COG1215	transferase activity, transferring glycosyl groups
C5N96_RS03700	COG0438	transferase activity, transferring glycosyl groups
C5N96_RS03710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5N96_RS03720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5N96_RS03730	COG0482	sulfurtransferase activity
C5N96_RS03735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5N96_RS03745	COG2860	membrane
C5N96_RS03750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5N96_RS03755	COG2001	Belongs to the MraZ family
C5N96_RS03760	COG0275	rRNA processing
C5N96_RS03770	COG0768	penicillin binding
C5N96_RS03775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5N96_RS03780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5N96_RS03785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5N96_RS03790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5N96_RS03800	COG0772	Belongs to the SEDS family
C5N96_RS03805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5N96_RS03810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5N96_RS03815	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5N96_RS03825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5N96_RS03830	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5N96_RS03835	COG0321	lipoyl(octanoyl) transferase activity
C5N96_RS03840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5N96_RS03845	COG0066	3-isopropylmalate dehydratase activity
C5N96_RS03855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N96_RS03865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5N96_RS03870	COG4608	Belongs to the ABC transporter superfamily
C5N96_RS03880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5N96_RS03885	COG0052	Belongs to the universal ribosomal protein uS2 family
C5N96_RS03895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C5N96_RS03910	COG1137	ATPase activity
C5N96_RS03920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5N96_RS03945	COG0017	Asparaginyl-tRNA synthetase
C5N96_RS03955	COG3118	belongs to the thioredoxin family
C5N96_RS04000	COG0583	DNA-binding transcription factor activity
C5N96_RS04005	COG2855	membrane
C5N96_RS04010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5N96_RS04020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5N96_RS04030	COG0602	queuosine metabolic process
C5N96_RS04035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5N96_RS04040	COG0217	transcriptional regulatory protein
C5N96_RS04045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5N96_RS04050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5N96_RS04050	COG4651	solute:proton antiporter activity
C5N96_RS04060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5N96_RS04065	COG4864	UPF0365 protein
C5N96_RS04075	COG2022	thiamine diphosphate biosynthetic process
C5N96_RS04080	COG0531	amino acid
C5N96_RS04090	COG0628	permease
C5N96_RS04095	COG0019	diaminopimelate decarboxylase activity
C5N96_RS04100	COG0191	fructose-bisphosphate aldolase activity
C5N96_RS04105	COG1217	gtp-binding protein TYPA
C5N96_RS04135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5N96_RS04145	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5N96_RS04165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5N96_RS04170	COG0516	GMP reductase activity
C5N96_RS04170	COG0517	IMP dehydrogenase activity
C5N96_RS04175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5N96_RS04175	COG0519	Catalyzes the synthesis of GMP from XMP
C5N96_RS04185	COG0546	phosphoglycolate phosphatase activity
C5N96_RS04210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5N96_RS04225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5N96_RS04230	COG0196	riboflavin kinase activity
C5N96_RS04235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5N96_RS04250	COG1408	metallophosphoesterase
C5N96_RS04260	COG1442	glycosyl transferase family 8
C5N96_RS04260	COG1216	Glycosyl transferase, family 2
C5N96_RS04270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5N96_RS04275	COG1216	Glycosyl transferase, family 2
C5N96_RS04295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5N96_RS04295	COG2755	lipolytic protein G-D-S-L family
C5N96_RS04310	COG0490	domain, Protein
C5N96_RS04310	COG0471	metal ion transport
C5N96_RS04345	COG0588	phosphoglycerate mutase activity
C5N96_RS04350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5N96_RS04360	COG0477	Major facilitator Superfamily
C5N96_RS04365	COG1607	acyl-coa hydrolase
C5N96_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
C5N96_RS04385	COG1525	nuclease
C5N96_RS04400	COG1475	DNA binding
C5N96_RS04405	COG3969	phosphoadenosine phosphosulfate
C5N96_RS04420	COG0473	3-isopropylmalate dehydrogenase activity
C5N96_RS04445	COG2873	o-acetylhomoserine
C5N96_RS04450	COG0535	radical SAM domain protein
C5N96_RS04455	COG0535	radical SAM domain protein
C5N96_RS04470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5N96_RS04475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5N96_RS04485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5N96_RS04490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5N96_RS04490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5N96_RS04490	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5N96_RS04490	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5N96_RS04500	COG1733	regulation of RNA biosynthetic process
C5N96_RS04510	COG0107	imidazoleglycerol-phosphate synthase activity
C5N96_RS04520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5N96_RS04530	COG1643	Atp-dependent helicase
C5N96_RS04535	COG0440	acetolactate synthase activity
C5N96_RS04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N96_RS04550	COG0445	tRNA wobble uridine modification
C5N96_RS04555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5N96_RS04555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5N96_RS04560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5N96_RS04580	COG2963	transposase activity
C5N96_RS04600	COG0592	DNA-directed DNA polymerase activity
C5N96_RS04625	COG1388	LysM domain
C5N96_RS04625	COG0791	NLP P60 protein
C5N96_RS04630	COG0084	hydrolase, TatD family'
C5N96_RS04640	COG3250	beta-galactosidase activity
C5N96_RS04655	COG2205	protein histidine kinase activity
C5N96_RS04660	COG0745	RESPONSE REGULATOR receiver
C5N96_RS04670	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5N96_RS04695	COG0542	response to heat
C5N96_RS04740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5N96_RS04750	COG0659	secondary active sulfate transmembrane transporter activity
C5N96_RS04755	COG0165	Argininosuccinate lyase
C5N96_RS04770	COG0148	phosphopyruvate hydratase activity
C5N96_RS04775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5N96_RS04785	COG3481	metal-dependent phosphohydrolase, HD sub domain
C5N96_RS04795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5N96_RS04800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5N96_RS04820	COG0732	type I restriction modification DNA specificity domain
C5N96_RS04845	COG3345	alpha-galactosidase
C5N96_RS04875	COG2985	domain, Protein
C5N96_RS04875	COG0490	domain, Protein
C5N96_RS04890	COG0471	metal ion transport
C5N96_RS04915	COG2194	sulfuric ester hydrolase activity
C5N96_RS04920	COG1592	Rubrerythrin
C5N96_RS04930	COG1363	Peptidase, m42
C5N96_RS04935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS04945	COG1785	Belongs to the alkaline phosphatase family
C5N96_RS04950	COG1970	mechanosensitive ion channel activity
C5N96_RS04955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5N96_RS04965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5N96_RS04975	COG2217	Heavy metal translocating P-type atpase
C5N96_RS04980	COG0497	DNA recombination
C5N96_RS04985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5N96_RS04985	COG0321	lipoyl(octanoyl) transferase activity
C5N96_RS04990	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C5N96_RS05020	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5N96_RS05025	COG0022	dehydrogenase e1 component
C5N96_RS05030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5N96_RS05040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5N96_RS05045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5N96_RS05100	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5N96_RS05100	COG3409	Peptidoglycan-binding domain 1 protein
C5N96_RS05105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5N96_RS05135	COG1690	Belongs to the RtcB family
C5N96_RS05145	COG2814	Major facilitator Superfamily
C5N96_RS05155	COG2096	Adenosyltransferase
C5N96_RS05165	COG0557	exoribonuclease II activity
C5N96_RS05195	COG0826	peptidase U32
C5N96_RS05200	COG0285	dihydrofolate synthase activity
C5N96_RS05215	COG0673	inositol 2-dehydrogenase activity
C5N96_RS05220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5N96_RS05225	COG0737	Belongs to the 5'-nucleotidase family
C5N96_RS05235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5N96_RS05240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5N96_RS05255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5N96_RS05260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5N96_RS05265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5N96_RS05270	COG0200	Binds to the 23S rRNA
C5N96_RS05275	COG0201	protein transport
C5N96_RS05280	COG0563	adenylate kinase activity
C5N96_RS05285	COG0024	Methionine aminopeptidase
C5N96_RS05300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5N96_RS05305	COG1442	glycosyl transferase family 8
C5N96_RS05315	COG1216	Glycosyl transferase, family 2
C5N96_RS05325	COG1216	Glycosyl transferase, family 2
C5N96_RS05340	COG1216	Glycosyl transferase, family 2
C5N96_RS05345	COG0693	protein deglycase activity
C5N96_RS05350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5N96_RS05355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5N96_RS05360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5N96_RS05370	COG1966	Carbon starvation protein
C5N96_RS05380	COG3119	arylsulfatase activity
C5N96_RS05385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5N96_RS05390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5N96_RS05395	COG0195	Participates in both transcription termination and antitermination
C5N96_RS05400	COG0708	Exodeoxyribonuclease III
C5N96_RS05405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5N96_RS05410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C5N96_RS05415	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5N96_RS05425	COG1131	(ABC) transporter
C5N96_RS05425	COG1716	ATPase activity
C5N96_RS05425	COG0842	Transport permease protein
C5N96_RS05445	COG0724	RNA recognition motif
C5N96_RS05450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5N96_RS05470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5N96_RS05480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5N96_RS05485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5N96_RS05500	COG1490	D-aminoacyl-tRNA deacylase activity
C5N96_RS05510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5N96_RS05515	COG1053	succinate dehydrogenase
C5N96_RS05560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5N96_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
C5N96_RS05575	COG0488	(ABC) transporter
C5N96_RS05585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5N96_RS05595	COG1253	flavin adenine dinucleotide binding
C5N96_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
C5N96_RS05610	COG1073	alpha beta
C5N96_RS05620	COG0667	Aldo Keto reductase
C5N96_RS05675	COG2267	carboxylic ester hydrolase activity
C5N96_RS05680	COG2095	MarC family integral membrane protein
C5N96_RS05710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5N96_RS05715	COG0488	(ABC) transporter
C5N96_RS05720	COG0697	spore germination
C5N96_RS05730	COG0215	cysteine-tRNA ligase activity
C5N96_RS05740	COG3119	arylsulfatase activity
C5N96_RS05755	COG0481	GTPase activity
C5N96_RS05775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5N96_RS05780	COG0085	RNA polymerase activity
C5N96_RS05785	COG0222	ribosome binding
C5N96_RS05790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5N96_RS05795	COG0081	regulation of translation
C5N96_RS05800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5N96_RS05805	COG0250	Participates in transcription elongation, termination and antitermination
C5N96_RS05820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5N96_RS05830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5N96_RS05840	COG0740	serine-type endopeptidase activity
C5N96_RS05845	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5N96_RS05860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5N96_RS05880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5N96_RS05925	COG2226	methyltransferase
C5N96_RS05930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5N96_RS05935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5N96_RS05950	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5N96_RS05950	COG1902	pentaerythritol trinitrate reductase activity
C5N96_RS05960	COG3119	arylsulfatase activity
C5N96_RS05965	COG0514	ATP-dependent DNA helicase (RecQ)
C5N96_RS05985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5N96_RS05990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5N96_RS06045	COG1858	cytochrome C peroxidase
C5N96_RS06050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5N96_RS06055	COG0590	tRNA wobble adenosine to inosine editing
C5N96_RS06060	COG1940	carbohydrate kinase activity
C5N96_RS06065	COG2217	Heavy metal translocating P-type atpase
C5N96_RS06070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5N96_RS06100	COG1363	Peptidase, m42
C5N96_RS06105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5N96_RS06115	COG0006	proline dipeptidase activity
C5N96_RS06120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5N96_RS06145	COG5002	protein histidine kinase activity
C5N96_RS06150	COG0745	RESPONSE REGULATOR receiver
C5N96_RS06155	COG0129	dihydroxy-acid dehydratase activity
C5N96_RS06250	COG1368	sulfuric ester hydrolase activity
C5N96_RS06285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5N96_RS06290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5N96_RS06310	COG0534	Mate efflux family protein
C5N96_RS06315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5N96_RS06330	COG1876	peptidase activity
C5N96_RS06465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5N96_RS06470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5N96_RS06475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5N96_RS06480	COG2205	protein histidine kinase activity
C5N96_RS06485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5N96_RS06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5N96_RS06510	COG0667	Aldo Keto reductase
C5N96_RS06515	COG0789	Transcriptional regulator
C5N96_RS06560	COG0714	Associated with various cellular activities
C5N96_RS06565	COG2311	Membrane
C5N96_RS06585	COG1090	epimerase
C5N96_RS06595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5N96_RS06600	COG1119	ATPase activity
C5N96_RS06605	COG2186	Transcriptional regulator
C5N96_RS06630	COG0148	phosphopyruvate hydratase activity
C5N96_RS06635	COG0436	Aminotransferase
C5N96_RS06640	COG1477	protein flavinylation
C5N96_RS06655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5N96_RS06665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5N96_RS06685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5N96_RS06695	COG1199	ATP-dependent helicase activity
C5N96_RS06700	COG1122	ATPase activity
C5N96_RS06725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5N96_RS06730	COG0598	Magnesium transport protein CorA
C5N96_RS06735	COG0359	binds to the 23S rRNA
C5N96_RS06740	COG0138	bifunctional purine biosynthesis protein purh
C5N96_RS06745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5N96_RS06750	COG0736	holo-[acyl-carrier-protein] synthase activity
C5N96_RS06760	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C5N96_RS06765	COG3409	Peptidoglycan-binding domain 1 protein
C5N96_RS06765	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5N96_RS06770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5N96_RS06780	COG0437	4 iron, 4 sulfur cluster binding
C5N96_RS06800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5N96_RS06850	COG0284	orotidine-5'-phosphate decarboxylase activity
C5N96_RS06870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5N96_RS06875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5N96_RS06895	COG2003	Belongs to the UPF0758 family
C5N96_RS06900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5N96_RS06900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5N96_RS06905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5N96_RS06910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5N96_RS06915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5N96_RS06920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5N96_RS06925	COG0322	excinuclease ABC activity
C5N96_RS06930	COG0811	peptide transport
C5N96_RS06935	COG0848	biopolymer transport protein
C5N96_RS06945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5N96_RS06950	COG0483	inositol monophosphate 1-phosphatase activity
C5N96_RS06955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5N96_RS06965	COG1482	cell wall glycoprotein biosynthetic process
C5N96_RS06975	COG1757	Na H antiporter
C5N96_RS06980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5N96_RS06985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5N96_RS06990	COG0505	Belongs to the CarA family
C5N96_RS06995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5N96_RS07010	COG0069	glutamate synthase activity
C5N96_RS07010	COG0070	glutamate synthase
C5N96_RS07010	COG0067	glutamate synthase
C5N96_RS07015	COG0706	membrane insertase activity
C5N96_RS07020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5N96_RS07030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5N96_RS07045	COG2755	lipolytic protein G-D-S-L family
C5N96_RS07045	COG0657	acetylesterase activity
C5N96_RS07055	COG0676	glucose-6-phosphate 1-epimerase activity
C5N96_RS07060	COG0259	pyridoxamine-phosphate oxidase activity
C5N96_RS07075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5N96_RS07090	COG1760	l-serine dehydratase
C5N96_RS07095	COG0492	ferredoxin-NADP+ reductase activity
C5N96_RS07095	COG3118	belongs to the thioredoxin family
C5N96_RS07145	COG1408	metallophosphoesterase
C5N96_RS07155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5N96_RS07160	COG0545	Peptidyl-prolyl cis-trans isomerase
C5N96_RS07175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5N96_RS07185	COG0826	peptidase U32
C5N96_RS07190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5N96_RS07210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5N96_RS07230	COG2895	sulfate adenylyltransferase (ATP) activity
C5N96_RS07230	COG0529	Catalyzes the synthesis of activated sulfate
C5N96_RS07235	COG0175	sulfate reduction
C5N96_RS07240	COG0175	sulfate reduction
C5N96_RS07260	COG0581	inorganic phosphate transmembrane transporter activity
C5N96_RS07265	COG0573	inorganic phosphate transmembrane transporter activity
C5N96_RS07275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5N96_RS07285	COG2017	converts alpha-aldose to the beta-anomer
C5N96_RS07300	COG0612	Peptidase, M16
C5N96_RS07340	COG0233	cytoplasmic translational termination
C5N96_RS07345	COG0528	UMP kinase activity
C5N96_RS07350	COG0668	transmembrane transport
C5N96_RS07355	COG0450	alkyl hydroperoxide reductase
C5N96_RS07360	COG0733	neurotransmitter:sodium symporter activity
C5N96_RS07375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5N96_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5N96_RS07390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5N96_RS07395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5N96_RS07415	COG0842	Transport permease protein
C5N96_RS07420	COG0842	Transport permease protein
C5N96_RS07425	COG1131	(ABC) transporter
C5N96_RS07435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5N96_RS07440	COG1183	phosphatidylcholine synthase activity
C5N96_RS07450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5N96_RS07460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5N96_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
C5N96_RS07485	COG0156	8-amino-7-oxononanoate synthase activity
C5N96_RS07510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5N96_RS07515	COG0124	histidyl-tRNA synthetase
C5N96_RS07520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5N96_RS07525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5N96_RS07530	COG0298	carbon dioxide binding
C5N96_RS07550	COG0438	transferase activity, transferring glycosyl groups
C5N96_RS07555	COG0443	Heat shock 70 kDa protein
C5N96_RS07560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5N96_RS07565	COG0459	protein refolding
C5N96_RS07615	COG0632	four-way junction helicase activity
C5N96_RS07625	COG0126	phosphoglycerate kinase activity
C5N96_RS07635	COG1082	Xylose isomerase domain protein TIM barrel
C5N96_RS07645	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C5N96_RS07655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5N96_RS07665	COG2271	Major facilitator Superfamily
C5N96_RS07680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5N96_RS07690	COG0037	tRNA processing
C5N96_RS07695	COG0254	rRNA binding
C5N96_RS07735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5N96_RS07740	COG0039	L-malate dehydrogenase activity
C5N96_RS07760	COG0778	Nitroreductase
C5N96_RS07765	COG0564	pseudouridine synthase activity
C5N96_RS07790	COG1126	abc transporter atp-binding protein
C5N96_RS07795	COG0765	amino acid transport
C5N96_RS07805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5N96_RS07810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5N96_RS07860	COG1872	DUF167
C5N96_RS07865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5N96_RS07870	COG0484	heat shock protein binding
C5N96_RS07875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5N96_RS07885	COG5434	Belongs to the glycosyl hydrolase 28 family
C5N96_RS07900	COG0277	FAD linked oxidase domain protein
C5N96_RS07925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5N96_RS07930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5N96_RS07940	COG0131	Imidazoleglycerol-phosphate dehydratase
C5N96_RS07945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5N96_RS07950	COG0360	Binds together with S18 to 16S ribosomal RNA
C5N96_RS07955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5N96_RS07970	COG1686	Belongs to the peptidase S11 family
C5N96_RS07975	COG0205	6-phosphofructokinase activity
C5N96_RS07985	COG0428	transporter
C5N96_RS07990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5N96_RS08010	COG3977	Valine--pyruvate aminotransferase
C5N96_RS08015	COG1561	YicC-like family, N-terminal region
C5N96_RS08025	COG3273	potassium ion transport
C5N96_RS08025	COG0471	metal ion transport
C5N96_RS08030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5N96_RS08045	COG1575	Belongs to the MenA family. Type 1 subfamily
C5N96_RS08080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5N96_RS08080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5N96_RS08100	COG0202	RNA polymerase activity
C5N96_RS08105	COG0203	ribosomal protein L17
C5N96_RS08110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5N96_RS08120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5N96_RS08135	COG2885	chlorophyll binding
C5N96_RS08190	COG0667	Aldo Keto reductase
C5N96_RS08195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5N96_RS08210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5N96_RS08215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5N96_RS08220	COG0134	indole-3-glycerol-phosphate synthase activity
C5N96_RS08225	COG0135	phosphoribosylanthranilate isomerase activity
C5N96_RS08230	COG0133	tryptophan synthase activity
C5N96_RS08235	COG0159	tryptophan synthase activity
C5N96_RS08250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5N96_RS08255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5N96_RS08265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5N96_RS08305	COG0561	phosphatase activity
C5N96_RS08310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5N96_RS08315	COG2223	nitrite transmembrane transporter activity
C5N96_RS08330	COG0556	nucleotide-excision repair
C5N96_RS08335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5N96_RS08340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5N96_RS08360	COG1074	ATP-dependent DNA helicase activity
C5N96_RS08370	COG0697	spore germination
C5N96_RS08375	COG2373	Large extracellular alpha-helical protein
C5N96_RS08380	COG1979	alcohol dehydrogenase
C5N96_RS08390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5N96_RS08415	COG0372	Belongs to the citrate synthase family
C5N96_RS08435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5N96_RS08445	COG1187	pseudouridine synthase activity
C5N96_RS08455	COG0105	UTP biosynthetic process
C5N96_RS08460	COG1215	transferase activity, transferring glycosyl groups
C5N96_RS08465	COG0463	Glycosyl transferase, family 2
C5N96_RS08475	COG1459	type II secretion system
C5N96_RS08480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5N96_RS08485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5N96_RS08490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5N96_RS08505	COG0728	peptidoglycan biosynthetic process
C5N96_RS08510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5N96_RS08510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5N96_RS08520	COG1649	PFAM Uncharacterised BCR, COG1649
C5N96_RS08525	COG1691	(AIR) carboxylase
C5N96_RS08530	COG1606	tRNA processing
C5N96_RS08535	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C5N96_RS08540	COG0142	geranyltranstransferase activity
C5N96_RS08555	COG2151	metal-sulfur cluster biosynthetic enzyme
C5N96_RS08575	COG1007	ATP synthesis coupled electron transport
C5N96_RS08580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5N96_RS08590	COG0713	ATP synthesis coupled electron transport
C5N96_RS08595	COG0839	Belongs to the complex I subunit 6 family
C5N96_RS08605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5N96_RS08610	COG1034	ATP synthesis coupled electron transport
C5N96_RS08615	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5N96_RS08620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C5N96_RS08625	COG0649	NAD binding
C5N96_RS08635	COG0726	polysaccharide deacetylase
C5N96_RS08645	COG0307	riboflavin synthase, alpha
C5N96_RS08650	COG2264	protein methyltransferase activity
C5N96_RS08660	COG3210	domain, Protein
C5N96_RS08665	COG1640	4-alpha-glucanotransferase
C5N96_RS08675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5N96_RS08680	COG1030	water channel activity
C5N96_RS08685	COG0358	DNA primase activity
C5N96_RS08690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5N96_RS08695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C5N96_RS08710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5N96_RS08715	COG0793	Belongs to the peptidase S41A family
C5N96_RS08730	COG1643	Atp-dependent helicase
C5N96_RS08755	COG1450	Type ii and iii secretion system protein
C5N96_RS08770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5N96_RS08790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5N96_RS08795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5N96_RS08805	COG0268	Binds directly to 16S ribosomal RNA
C5N96_RS08810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5N96_RS08815	COG0028	Belongs to the TPP enzyme family
C5N96_RS08825	COG0688	phosphatidylethanolamine metabolic process
C5N96_RS08830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5N96_RS08835	COG0495	leucyl-tRNA aminoacylation
C5N96_RS08840	COG3119	arylsulfatase activity
C5N96_RS08855	COG1166	arginine decarboxylase activity
C5N96_RS08865	COG3250	beta-galactosidase activity
C5N96_RS08870	COG3250	beta-galactosidase activity
C5N96_RS08875	COG3250	beta-galactosidase activity
C5N96_RS08880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5N96_RS08885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS08895	COG0205	6-phosphofructokinase activity
C5N96_RS08915	COG0535	radical SAM domain protein
C5N96_RS08960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5N96_RS08965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C5N96_RS08975	COG4771	TonB-dependent receptor
C5N96_RS08995	COG0402	S-adenosylhomocysteine deaminase activity
C5N96_RS09000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5N96_RS09020	COG1294	oxidase, subunit
C5N96_RS09025	COG1271	oxidase subunit
C5N96_RS09035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5N96_RS09055	COG1846	Transcriptional regulator
C5N96_RS09085	COG2949	membrane
C5N96_RS09110	COG0514	ATP-dependent DNA helicase (RecQ)
C5N96_RS09125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5N96_RS09130	COG0045	succinate-CoA ligase (ADP-forming) activity
C5N96_RS09135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5N96_RS09190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5N96_RS09195	COG2205	protein histidine kinase activity
C5N96_RS09210	COG0113	porphobilinogen synthase activity
C5N96_RS09220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5N96_RS09225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5N96_RS09255	COG0732	type I restriction modification DNA specificity domain
C5N96_RS09265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5N96_RS09290	COG4106	trans-aconitate 2-methyltransferase activity
C5N96_RS09305	COG3475	LICD family
C5N96_RS09310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5N96_RS09320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5N96_RS09325	COG3475	LICD family
C5N96_RS09330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5N96_RS09340	COG2166	iron-sulfur cluster assembly
C5N96_RS09345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5N96_RS09355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5N96_RS09360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5N96_RS09365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5N96_RS09370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5N96_RS09375	COG1131	(ABC) transporter
C5N96_RS09390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5N96_RS09405	COG1215	transferase activity, transferring glycosyl groups
C5N96_RS09420	COG1401	restriction endodeoxyribonuclease activity
C5N96_RS09420	COG1401	restriction endodeoxyribonuclease activity
C5N96_RS09430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5N96_RS09435	COG1522	sequence-specific DNA binding
C5N96_RS09440	COG0436	Aminotransferase
C5N96_RS09455	COG0423	glycine-tRNA ligase activity
C5N96_RS09460	COG0656	L-ascorbic acid biosynthetic process
C5N96_RS09475	COG2304	oxidoreductase activity
C5N96_RS09490	COG0714	Associated with various cellular activities
C5N96_RS09495	COG0154	amidase activity
C5N96_RS09500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5N96_RS09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N96_RS09550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5N96_RS09550	COG2755	lipolytic protein G-D-S-L family
C5N96_RS09570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5N96_RS09580	COG0656	L-ascorbic acid biosynthetic process
C5N96_RS09590	COG0667	Aldo Keto reductase
C5N96_RS09595	COG1408	metallophosphoesterase
C5N96_RS09615	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5N96_RS09620	COG0789	Transcriptional regulator
C5N96_RS09635	COG0534	Mate efflux family protein
C5N96_RS09655	COG1091	dTDP-4-dehydrorhamnose reductase activity
C5N96_RS09670	COG1837	Belongs to the UPF0109 family
C5N96_RS09675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5N96_RS09680	COG0363	glucosamine-6-phosphate deaminase activity
C5N96_RS09700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C5N96_RS09725	COG1070	Carbohydrate kinase
C5N96_RS09740	COG0738	Major facilitator superfamily
C5N96_RS09755	COG1595	DNA-templated transcription, initiation
C5N96_RS09770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5N96_RS09790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5N96_RS09795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5N96_RS09800	COG0697	spore germination
C5N96_RS09805	COG3586	endonuclease activity
C5N96_RS09815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5N96_RS09820	COG4608	Belongs to the ABC transporter superfamily
C5N96_RS09825	COG0444	Belongs to the ABC transporter superfamily
C5N96_RS09830	COG4166	transmembrane transport
C5N96_RS09835	COG4239	(ABC) transporter, permease
C5N96_RS09840	COG0601	transmembrane transport
C5N96_RS09855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5N96_RS09860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C5N96_RS09865	COG3738	Protein conserved in bacteria
C5N96_RS09870	COG0151	Belongs to the GarS family
C5N96_RS09885	COG0811	peptide transport
C5N96_RS09895	COG0242	peptide deformylase activity
C5N96_RS09905	COG0297	glycogen (starch) synthase activity
C5N96_RS09940	COG3258	Cytochrome c
C5N96_RS09955	COG3274	enterobacterial common antigen metabolic process
C5N96_RS09960	COG0538	isocitrate dehydrogenase activity
C5N96_RS09975	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5N96_RS09980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5N96_RS09985	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5N96_RS09995	COG0668	transmembrane transport
C5N96_RS10000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5N96_RS10000	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5N96_RS10005	COG0805	protein transport
C5N96_RS10010	COG1968	undecaprenyl-diphosphatase activity
C5N96_RS10030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5N96_RS10040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5N96_RS10050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5N96_RS10060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5N96_RS10070	COG1408	metallophosphoesterase
C5N96_RS10095	COG4974	Belongs to the 'phage' integrase family
C5N96_RS10115	COG1454	alcohol dehydrogenase
C5N96_RS10120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5N96_RS10130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C5N96_RS10130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5N96_RS10135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5N96_RS10175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5N96_RS10185	COG4607	ABC-type enterochelin transport system periplasmic component
C5N96_RS10190	COG4604	ABC transporter, ATP-binding protein
C5N96_RS10195	COG4605	iron ion homeostasis
C5N96_RS10200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5N96_RS10235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5N96_RS10235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5N96_RS10250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5N96_RS10255	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5N96_RS10275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5N96_RS10290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5N96_RS10315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5N96_RS10350	COG0646	methionine synthase
C5N96_RS10350	COG1410	methionine synthase
C5N96_RS10355	COG2966	Psort location CytoplasmicMembrane, score
C5N96_RS10360	COG3610	response to peptide
C5N96_RS10375	COG0460	homoserine dehydrogenase
C5N96_RS10380	COG0527	aspartate kinase activity
C5N96_RS10390	COG5522	Integral membrane protein (intg_mem_TP0381)
C5N96_RS10400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5N96_RS10405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5N96_RS10415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C5N96_RS10420	COG0574	Belongs to the PEP-utilizing enzyme family
C5N96_RS10420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5N96_RS10425	COG0166	Belongs to the GPI family
C5N96_RS10435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5N96_RS10445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5N96_RS10445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5N96_RS10480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5N96_RS10485	COG2818	Glycosylase
C5N96_RS10505	COG3033	Beta-eliminating lyase
C5N96_RS10520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N96_RS10520	COG0072	phenylalanine-tRNA ligase activity
C5N96_RS10540	COG0326	Molecular chaperone. Has ATPase activity
C5N96_RS10565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5N96_RS10570	COG1959	2 iron, 2 sulfur cluster binding
C5N96_RS10585	COG0352	thiamine-phosphate diphosphorylase activity
C5N96_RS10590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C5N96_RS10605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS10615	COG1703	isobutyryl-CoA mutase activity
C5N96_RS10635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5N96_RS10645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5N96_RS10650	COG0418	dihydroorotase activity
C5N96_RS10665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5N96_RS10685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5N96_RS10700	COG0534	Mate efflux family protein
C5N96_RS10705	COG0489	protein tyrosine kinase activity
C5N96_RS10715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5N96_RS10720	COG0339	signal peptide processing
C5N96_RS10725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5N96_RS10735	COG1538	Outer membrane efflux protein
C5N96_RS10750	COG4112	unkown
C5N96_RS10765	COG0038	chloride channel
C5N96_RS10775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5N96_RS10780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5N96_RS10785	COG0586	Pfam SNARE associated Golgi protein
C5N96_RS10855	COG1012	belongs to the aldehyde dehydrogenase family
C5N96_RS10870	COG0753	catalase activity
C5N96_RS10880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5N96_RS10885	COG1592	Rubrerythrin
C5N96_RS10890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5N96_RS10925	COG0489	protein tyrosine kinase activity
C5N96_RS10935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5N96_RS10945	COG2244	polysaccharide biosynthetic process
C5N96_RS10950	COG1215	transferase activity, transferring glycosyl groups
C5N96_RS10960	COG1216	Glycosyl transferase, family 2
C5N96_RS10975	COG0438	transferase activity, transferring glycosyl groups
C5N96_RS11005	COG1216	Glycosyl transferase, family 2
C5N96_RS11030	COG2755	lipolytic protein G-D-S-L family
C5N96_RS11030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5N96_RS11050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5N96_RS11055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N96_RS11055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5N96_RS11060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C5N96_RS11065	COG0281	malic enzyme
C5N96_RS11065	COG0280	phosphate acetyltransferase
C5N96_RS11080	COG1472	Belongs to the glycosyl hydrolase 3 family
C5N96_RS11085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5N96_RS11100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5N96_RS11140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5N96_RS11145	COG1063	alcohol dehydrogenase
C5N96_RS11160	COG0714	Associated with various cellular activities
C5N96_RS11170	COG0193	aminoacyl-tRNA hydrolase activity
C5N96_RS11175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5N96_RS11190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5N96_RS11215	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5N96_RS11230	COG0375	protein maturation
C5N96_RS11255	COG0778	Nitroreductase
C5N96_RS11260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5N96_RS11295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5N96_RS11295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5N96_RS11315	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C5N96_RS11335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5N96_RS11340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5N96_RS11345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5N96_RS11395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5N96_RS11400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5N96_RS11415	COG0318	PFAM AMP-dependent synthetase and ligase
C5N96_RS11435	COG0339	signal peptide processing
C5N96_RS11445	COG0018	arginyl-trna synthetase
C5N96_RS11490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5N96_RS11495	COG0653	protein targeting
C5N96_RS11510	COG0494	nUDIX hydrolase
C5N96_RS11515	COG1715	Restriction endonuclease
C5N96_RS11525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5N96_RS11575	COG0732	type I restriction modification DNA specificity domain