locus-tag	class	description
DMI78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI78_RS00010	COG1131	(ABC) transporter
DMI78_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMI78_RS00035	COG0564	pseudouridine synthase activity
DMI78_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMI78_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMI78_RS00065	COG0513	Belongs to the DEAD box helicase family
DMI78_RS00075	COG0673	inositol 2-dehydrogenase activity
DMI78_RS00095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DMI78_RS00110	COG1971	Probably functions as a manganese efflux pump
DMI78_RS00135	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DMI78_RS00330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI78_RS00355	COG0442	prolyl-tRNA aminoacylation
DMI78_RS00390	COG0531	amino acid
DMI78_RS00395	COG2066	Belongs to the glutaminase family
DMI78_RS00405	COG1115	amino acid carrier protein
DMI78_RS00415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMI78_RS00420	COG2890	protein-(glutamine-N5) methyltransferase activity
DMI78_RS00425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMI78_RS00430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DMI78_RS00445	COG2226	methyltransferase
DMI78_RS00450	COG0534	Mate efflux family protein
DMI78_RS00460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI78_RS00465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMI78_RS00470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS00485	COG1121	(ABC) transporter
DMI78_RS00490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMI78_RS00495	COG3880	PFAM UvrB UvrC protein
DMI78_RS00500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMI78_RS00505	COG0542	response to heat
DMI78_RS00520	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMI78_RS00525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI78_RS00540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMI78_RS00540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI78_RS00555	COG0180	Tryptophanyl-tRNA synthetase
DMI78_RS00565	COG1692	metallophosphoesterase
DMI78_RS00570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMI78_RS00585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMI78_RS00590	COG2816	NAD+ diphosphatase activity
DMI78_RS00595	COG0156	8-amino-7-oxononanoate synthase activity
DMI78_RS00610	COG0515	serine threonine protein kinase
DMI78_RS00610	COG3266	domain, Protein
DMI78_RS00650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMI78_RS00660	COG3189	MarR family transcriptional regulator
DMI78_RS00665	COG0181	hydroxymethylbilane synthase activity
DMI78_RS00670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMI78_RS00680	COG1469	GTP cyclohydrolase I activity
DMI78_RS00685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMI78_RS00690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMI78_RS00700	COG1940	carbohydrate kinase activity
DMI78_RS00715	COG0494	nUDIX hydrolase
DMI78_RS00720	COG1566	PFAM secretion protein HlyD family protein
DMI78_RS00725	COG0577	efflux transmembrane transporter activity
DMI78_RS00725	COG1136	(ABC) transporter
DMI78_RS00730	COG0577	efflux transmembrane transporter activity
DMI78_RS00730	COG1136	(ABC) transporter
DMI78_RS00735	COG1538	Outer membrane efflux protein
DMI78_RS00745	COG1720	tRNA m6t6A37 methyltransferase activity
DMI78_RS00750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMI78_RS00755	COG0540	Belongs to the ATCase OTCase family
DMI78_RS00760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMI78_RS00775	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DMI78_RS00780	COG2957	Belongs to the agmatine deiminase family
DMI78_RS00790	COG0750	zinc metalloprotease
DMI78_RS00800	COG3119	arylsulfatase activity
DMI78_RS00810	COG1918	ferrous iron import across plasma membrane
DMI78_RS00810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI78_RS00860	COG1475	DNA binding
DMI78_RS00895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMI78_RS00905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMI78_RS00910	COG0601	transmembrane transport
DMI78_RS00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMI78_RS00970	COG1132	(ABC) transporter
DMI78_RS00975	COG1132	(ABC) transporter
DMI78_RS00990	COG1127	ABC transporter
DMI78_RS00995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DMI78_RS01025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMI78_RS01040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DMI78_RS01045	COG0504	CTP synthase activity
DMI78_RS01050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMI78_RS01075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI78_RS01085	COG1322	Protein conserved in bacteria
DMI78_RS01090	COG0546	phosphoglycolate phosphatase activity
DMI78_RS01095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI78_RS01105	COG4591	ABC-type transport system involved in lipoprotein release permease component
DMI78_RS01135	COG2755	lipolytic protein G-D-S-L family
DMI78_RS01135	COG0657	acetylesterase activity
DMI78_RS01140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMI78_RS01160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMI78_RS01165	COG2267	carboxylic ester hydrolase activity
DMI78_RS01175	COG0335	large ribosomal subunit rRNA binding
DMI78_RS01185	COG0346	lactoylglutathione lyase activity
DMI78_RS01200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DMI78_RS01205	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DMI78_RS01210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DMI78_RS01210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DMI78_RS01215	COG0427	acetyl-CoA hydrolase
DMI78_RS01225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DMI78_RS01235	COG0205	6-phosphofructokinase activity
DMI78_RS01245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI78_RS01250	COG0028	Belongs to the TPP enzyme family
DMI78_RS01270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DMI78_RS01285	COG0471	metal ion transport
DMI78_RS01295	COG0351	phosphomethylpyrimidine kinase
DMI78_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
DMI78_RS01355	COG0242	peptide deformylase activity
DMI78_RS01360	COG1063	alcohol dehydrogenase
DMI78_RS01370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMI78_RS01375	COG1393	Belongs to the ArsC family
DMI78_RS01380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI78_RS01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DMI78_RS01395	COG1187	pseudouridine synthase activity
DMI78_RS01405	COG0336	Belongs to the RNA methyltransferase TrmD family
DMI78_RS01420	COG0539	negative regulation of cytoplasmic translation
DMI78_RS01465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMI78_RS01470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMI78_RS01475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMI78_RS01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI78_RS01520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI78_RS01600	COG3015	lipoprotein NlpE involved in copper resistance
DMI78_RS01680	COG0305	Participates in initiation and elongation during chromosome replication
DMI78_RS01740	COG3645	SOS response
DMI78_RS01785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMI78_RS01785	COG0662	Cupin 2, conserved barrel domain protein
DMI78_RS01795	COG0416	fatty acid biosynthetic process
DMI78_RS01800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMI78_RS01810	COG0537	adenosine 5'-monophosphoramidase activity
DMI78_RS01815	COG0009	L-threonylcarbamoyladenylate synthase
DMI78_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMI78_RS01825	COG0228	four-way junction DNA binding
DMI78_RS01845	COG1862	Preprotein translocase
DMI78_RS01850	COG0343	queuine tRNA-ribosyltransferase activity
DMI78_RS01855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMI78_RS01865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DMI78_RS01870	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMI78_RS01875	COG0776	regulation of translation
DMI78_RS01905	COG0811	peptide transport
DMI78_RS01920	COG3250	beta-galactosidase activity
DMI78_RS01925	COG0525	valine-tRNA ligase activity
DMI78_RS01935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMI78_RS01940	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMI78_RS01945	COG0255	Belongs to the universal ribosomal protein uL29 family
DMI78_RS01950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMI78_RS01955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMI78_RS01960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMI78_RS01970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMI78_RS01975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMI78_RS01980	COG0089	rRNA binding
DMI78_RS01985	COG0088	Forms part of the polypeptide exit tunnel
DMI78_RS01990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMI78_RS01995	COG0051	transcription antitermination factor activity, RNA binding
DMI78_RS02000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMI78_RS02005	COG0049	tRNA binding
DMI78_RS02010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMI78_RS02015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMI78_RS02025	COG3852	Histidine kinase
DMI78_RS02030	COG2204	response regulator
DMI78_RS02040	COG1722	exodeoxyribonuclease VII activity
DMI78_RS02045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI78_RS02060	COG0795	lipopolysaccharide-transporting ATPase activity
DMI78_RS02065	COG1160	GTP binding
DMI78_RS02070	COG0444	Belongs to the ABC transporter superfamily
DMI78_RS02090	COG1136	(ABC) transporter
DMI78_RS02090	COG0577	efflux transmembrane transporter activity
DMI78_RS02100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI78_RS02220	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI78_RS02305	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DMI78_RS02345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMI78_RS02350	COG0799	negative regulation of ribosome biogenesis
DMI78_RS02355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMI78_RS02405	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DMI78_RS02420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DMI78_RS02430	COG0300	oxidoreductase activity
DMI78_RS02450	COG0038	chloride channel
DMI78_RS02460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS02475	COG0076	glutamate decarboxylase activity
DMI78_RS02490	COG0167	dihydroorotate dehydrogenase activity
DMI78_RS02495	COG0352	thiamine-phosphate diphosphorylase activity
DMI78_RS02515	COG1253	flavin adenine dinucleotide binding
DMI78_RS02520	COG1253	flavin adenine dinucleotide binding
DMI78_RS02525	COG1185	polyribonucleotide nucleotidyltransferase activity
DMI78_RS02530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMI78_RS02535	COG0110	maltose O-acetyltransferase activity
DMI78_RS02560	COG0101	tRNA pseudouridine synthase activity
DMI78_RS02565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMI78_RS02585	COG4968	Prepilin-type N-terminal cleavage methylation domain
DMI78_RS02600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS02610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMI78_RS02630	COG1136	(ABC) transporter
DMI78_RS02635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMI78_RS02645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI78_RS02670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS02675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DMI78_RS02680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DMI78_RS02690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMI78_RS02695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMI78_RS02705	COG2814	Major facilitator Superfamily
DMI78_RS02720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI78_RS02720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMI78_RS02725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMI78_RS02730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMI78_RS02735	COG0552	protein localization to endoplasmic reticulum
DMI78_RS02740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMI78_RS02760	COG1546	Belongs to the CinA family
DMI78_RS02760	COG1058	Belongs to the CinA family
DMI78_RS02770	COG0456	acetyltransferase
DMI78_RS02795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMI78_RS02800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMI78_RS02805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMI78_RS02810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMI78_RS02825	COG0758	DNA mediated transformation
DMI78_RS02830	COG1686	Belongs to the peptidase S11 family
DMI78_RS02835	COG0012	GTP binding
DMI78_RS02840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMI78_RS02850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI78_RS02850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMI78_RS02865	COG3119	arylsulfatase activity
DMI78_RS02890	COG2259	Doxx family
DMI78_RS02895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMI78_RS02925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI78_RS02945	COG2326	polyphosphate kinase activity
DMI78_RS02950	COG1349	DNA-binding transcription factor activity
DMI78_RS02965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMI78_RS02970	COG1162	GTPase activity
DMI78_RS02985	COG0742	ribosomal rna small subunit methyltransferase
DMI78_RS03000	COG2326	polyphosphate kinase activity
DMI78_RS03010	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI78_RS03020	COG1073	alpha beta
DMI78_RS03025	COG0802	atpase or kinase
DMI78_RS03030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMI78_RS03035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMI78_RS03040	COG0735	belongs to the Fur family
DMI78_RS03045	COG0396	ATPase activity
DMI78_RS03050	COG0719	Fe-S assembly protein
DMI78_RS03055	COG0719	Fe-S assembly protein
DMI78_RS03075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMI78_RS03115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMI78_RS03135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMI78_RS03140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMI78_RS03145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMI78_RS03150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMI78_RS03155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMI78_RS03160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMI78_RS03170	COG0356	it plays a direct role in the translocation of protons across the membrane
DMI78_RS03230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMI78_RS03260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DMI78_RS03265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DMI78_RS03270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMI78_RS03280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMI78_RS03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMI78_RS03295	COG0047	phosphoribosylformylglycinamidine synthase activity
DMI78_RS03305	COG1363	Peptidase, m42
DMI78_RS03320	COG1077	Cell shape determining protein MreB Mrl
DMI78_RS03325	COG1530	ribonuclease E activity
DMI78_RS03345	COG0848	biopolymer transport protein
DMI78_RS03360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMI78_RS03375	COG0134	indole-3-glycerol-phosphate synthase activity
DMI78_RS03390	COG1253	flavin adenine dinucleotide binding
DMI78_RS03400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMI78_RS03405	COG0137	argininosuccinate synthase activity
DMI78_RS03425	COG0149	triose-phosphate isomerase activity
DMI78_RS03460	COG1040	competence protein
DMI78_RS03470	COG3956	TIGRFAM MazG family protein
DMI78_RS03490	COG1663	tetraacyldisaccharide 4'-kinase activity
DMI78_RS03495	COG0612	Peptidase, M16
DMI78_RS03520	COG0673	inositol 2-dehydrogenase activity
DMI78_RS03525	COG3034	peptidoglycan biosynthetic process
DMI78_RS03545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMI78_RS03550	COG0424	maF-like protein
DMI78_RS03555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMI78_RS03560	COG2815	serine threonine protein kinase
DMI78_RS03560	COG0515	serine threonine protein kinase
DMI78_RS03585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMI78_RS03595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMI78_RS03605	COG0571	ribonuclease III activity
DMI78_RS03625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMI78_RS03640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DMI78_RS03660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI78_RS03685	COG2076	Multidrug Resistance protein
DMI78_RS03760	COG1431	PFAM Stem cell self-renewal protein Piwi
DMI78_RS03770	COG2255	four-way junction helicase activity
DMI78_RS03775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMI78_RS03780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI78_RS03785	COG1215	transferase activity, transferring glycosyl groups
DMI78_RS03790	COG1216	Glycosyl transferase, family 2
DMI78_RS03815	COG0438	transferase activity, transferring glycosyl groups
DMI78_RS03825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI78_RS03835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMI78_RS03840	COG0482	sulfurtransferase activity
DMI78_RS03845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMI78_RS03855	COG2860	membrane
DMI78_RS03860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI78_RS03865	COG2001	Belongs to the MraZ family
DMI78_RS03870	COG0275	rRNA processing
DMI78_RS03880	COG0768	penicillin binding
DMI78_RS03885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMI78_RS03890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMI78_RS03895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMI78_RS03900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMI78_RS03910	COG0772	Belongs to the SEDS family
DMI78_RS03915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMI78_RS03920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI78_RS03925	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMI78_RS03935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMI78_RS03940	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI78_RS03945	COG0321	lipoyl(octanoyl) transferase activity
DMI78_RS03950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMI78_RS03955	COG0066	3-isopropylmalate dehydratase activity
DMI78_RS03965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI78_RS03975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI78_RS03980	COG4608	Belongs to the ABC transporter superfamily
DMI78_RS03985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMI78_RS03990	COG0052	Belongs to the universal ribosomal protein uS2 family
DMI78_RS04000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DMI78_RS04015	COG1137	ATPase activity
DMI78_RS04025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMI78_RS04050	COG0017	Asparaginyl-tRNA synthetase
DMI78_RS04060	COG3118	belongs to the thioredoxin family
DMI78_RS04110	COG0583	DNA-binding transcription factor activity
DMI78_RS04115	COG2855	membrane
DMI78_RS04120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMI78_RS04130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMI78_RS04140	COG0602	queuosine metabolic process
DMI78_RS04145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI78_RS04150	COG0217	transcriptional regulatory protein
DMI78_RS04165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMI78_RS04170	COG4651	solute:proton antiporter activity
DMI78_RS04170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI78_RS04180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMI78_RS04185	COG4864	UPF0365 protein
DMI78_RS04195	COG2022	thiamine diphosphate biosynthetic process
DMI78_RS04200	COG0531	amino acid
DMI78_RS04210	COG0628	permease
DMI78_RS04215	COG0019	diaminopimelate decarboxylase activity
DMI78_RS04220	COG0191	fructose-bisphosphate aldolase activity
DMI78_RS04225	COG1217	gtp-binding protein TYPA
DMI78_RS04250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMI78_RS04280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI78_RS04285	COG0516	GMP reductase activity
DMI78_RS04285	COG0517	IMP dehydrogenase activity
DMI78_RS04290	COG0519	Catalyzes the synthesis of GMP from XMP
DMI78_RS04290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI78_RS04315	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DMI78_RS04345	COG0546	phosphoglycolate phosphatase activity
DMI78_RS04365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DMI78_RS04380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMI78_RS04385	COG0196	riboflavin kinase activity
DMI78_RS04390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMI78_RS04405	COG1408	metallophosphoesterase
DMI78_RS04415	COG1442	glycosyl transferase family 8
DMI78_RS04415	COG1216	Glycosyl transferase, family 2
DMI78_RS04425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI78_RS04430	COG1216	Glycosyl transferase, family 2
DMI78_RS04450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI78_RS04450	COG2755	lipolytic protein G-D-S-L family
DMI78_RS04465	COG0490	domain, Protein
DMI78_RS04465	COG0471	metal ion transport
DMI78_RS04500	COG0588	phosphoglycerate mutase activity
DMI78_RS04505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMI78_RS04515	COG0477	Major facilitator Superfamily
DMI78_RS04520	COG1607	acyl-coa hydrolase
DMI78_RS04535	COG1525	nuclease
DMI78_RS04550	COG1475	DNA binding
DMI78_RS04555	COG3969	phosphoadenosine phosphosulfate
DMI78_RS04575	COG0473	3-isopropylmalate dehydrogenase activity
DMI78_RS04600	COG2873	o-acetylhomoserine
DMI78_RS04605	COG0535	radical SAM domain protein
DMI78_RS04610	COG0535	radical SAM domain protein
DMI78_RS04625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMI78_RS04630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMI78_RS04640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMI78_RS04645	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMI78_RS04645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMI78_RS04645	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DMI78_RS04645	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMI78_RS04655	COG1733	regulation of RNA biosynthetic process
DMI78_RS04665	COG0107	imidazoleglycerol-phosphate synthase activity
DMI78_RS04675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI78_RS04685	COG1643	Atp-dependent helicase
DMI78_RS04690	COG0440	acetolactate synthase activity
DMI78_RS04695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI78_RS04705	COG0445	tRNA wobble uridine modification
DMI78_RS04710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI78_RS04710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMI78_RS04715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMI78_RS04725	COG0592	DNA-directed DNA polymerase activity
DMI78_RS04750	COG1388	LysM domain
DMI78_RS04750	COG0791	NLP P60 protein
DMI78_RS04755	COG0084	hydrolase, TatD family'
DMI78_RS04765	COG3250	beta-galactosidase activity
DMI78_RS04780	COG2205	protein histidine kinase activity
DMI78_RS04785	COG0745	RESPONSE REGULATOR receiver
DMI78_RS04795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI78_RS04805	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI78_RS04820	COG0542	response to heat
DMI78_RS04865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMI78_RS04875	COG0659	secondary active sulfate transmembrane transporter activity
DMI78_RS04880	COG0165	Argininosuccinate lyase
DMI78_RS04895	COG0148	phosphopyruvate hydratase activity
DMI78_RS04900	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMI78_RS04910	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMI78_RS04920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI78_RS04925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMI78_RS04955	COG2985	domain, Protein
DMI78_RS04955	COG0490	domain, Protein
DMI78_RS04970	COG0471	metal ion transport
DMI78_RS04995	COG2194	sulfuric ester hydrolase activity
DMI78_RS05000	COG1592	Rubrerythrin
DMI78_RS05010	COG1363	Peptidase, m42
DMI78_RS05015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS05025	COG1785	Belongs to the alkaline phosphatase family
DMI78_RS05030	COG1970	mechanosensitive ion channel activity
DMI78_RS05035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMI78_RS05045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMI78_RS05065	COG2217	Heavy metal translocating P-type atpase
DMI78_RS05070	COG0497	DNA recombination
DMI78_RS05075	COG0321	lipoyl(octanoyl) transferase activity
DMI78_RS05075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMI78_RS05080	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMI78_RS05110	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI78_RS05115	COG0022	dehydrogenase e1 component
DMI78_RS05120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DMI78_RS05130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI78_RS05135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI78_RS05195	COG3409	Peptidoglycan-binding domain 1 protein
DMI78_RS05195	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI78_RS05200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMI78_RS05225	COG1690	Belongs to the RtcB family
DMI78_RS05235	COG2814	Major facilitator Superfamily
DMI78_RS05245	COG2096	Adenosyltransferase
DMI78_RS05255	COG0557	exoribonuclease II activity
DMI78_RS05270	COG0826	peptidase U32
DMI78_RS05275	COG0285	dihydrofolate synthase activity
DMI78_RS05290	COG0673	inositol 2-dehydrogenase activity
DMI78_RS05295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DMI78_RS05300	COG0737	Belongs to the 5'-nucleotidase family
DMI78_RS05310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMI78_RS05315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMI78_RS05330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMI78_RS05335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMI78_RS05340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMI78_RS05345	COG0200	Binds to the 23S rRNA
DMI78_RS05350	COG0201	protein transport
DMI78_RS05355	COG0563	adenylate kinase activity
DMI78_RS05360	COG0024	Methionine aminopeptidase
DMI78_RS05375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMI78_RS05380	COG1442	glycosyl transferase family 8
DMI78_RS05390	COG1216	Glycosyl transferase, family 2
DMI78_RS05400	COG1216	Glycosyl transferase, family 2
DMI78_RS05415	COG1216	Glycosyl transferase, family 2
DMI78_RS05420	COG0693	protein deglycase activity
DMI78_RS05425	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMI78_RS05430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMI78_RS05435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI78_RS05445	COG1966	Carbon starvation protein
DMI78_RS05455	COG3119	arylsulfatase activity
DMI78_RS05460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMI78_RS05465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMI78_RS05470	COG0195	Participates in both transcription termination and antitermination
DMI78_RS05475	COG0708	Exodeoxyribonuclease III
DMI78_RS05480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMI78_RS05485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMI78_RS05490	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DMI78_RS05500	COG0842	Transport permease protein
DMI78_RS05500	COG1716	ATPase activity
DMI78_RS05500	COG1131	(ABC) transporter
DMI78_RS05520	COG0724	RNA recognition motif
DMI78_RS05525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI78_RS05545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMI78_RS05555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DMI78_RS05560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMI78_RS05575	COG1490	D-aminoacyl-tRNA deacylase activity
DMI78_RS05590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMI78_RS05595	COG1053	succinate dehydrogenase
DMI78_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
DMI78_RS05650	COG0488	(ABC) transporter
DMI78_RS05660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMI78_RS05670	COG1253	flavin adenine dinucleotide binding
DMI78_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
DMI78_RS05685	COG1073	alpha beta
DMI78_RS05695	COG0667	Aldo Keto reductase
DMI78_RS05750	COG2267	carboxylic ester hydrolase activity
DMI78_RS05755	COG2095	MarC family integral membrane protein
DMI78_RS05795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMI78_RS05800	COG0488	(ABC) transporter
DMI78_RS05810	COG0697	spore germination
DMI78_RS05820	COG0215	cysteine-tRNA ligase activity
DMI78_RS05830	COG3119	arylsulfatase activity
DMI78_RS05845	COG0481	GTPase activity
DMI78_RS05860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMI78_RS05865	COG0085	RNA polymerase activity
DMI78_RS05870	COG0222	ribosome binding
DMI78_RS05875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMI78_RS05880	COG0081	regulation of translation
DMI78_RS05885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMI78_RS05890	COG0250	Participates in transcription elongation, termination and antitermination
DMI78_RS05905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMI78_RS05915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DMI78_RS05925	COG0740	serine-type endopeptidase activity
DMI78_RS05930	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMI78_RS05945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMI78_RS05965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMI78_RS06005	COG2226	methyltransferase
DMI78_RS06010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMI78_RS06015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DMI78_RS06030	COG1902	pentaerythritol trinitrate reductase activity
DMI78_RS06030	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMI78_RS06040	COG3119	arylsulfatase activity
DMI78_RS06045	COG0514	ATP-dependent DNA helicase (RecQ)
DMI78_RS06065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DMI78_RS06070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMI78_RS06110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DMI78_RS06125	COG1858	cytochrome C peroxidase
DMI78_RS06130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMI78_RS06135	COG0590	tRNA wobble adenosine to inosine editing
DMI78_RS06140	COG1940	carbohydrate kinase activity
DMI78_RS06145	COG2217	Heavy metal translocating P-type atpase
DMI78_RS06150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMI78_RS06155	COG0237	dephospho-CoA kinase activity
DMI78_RS06185	COG1363	Peptidase, m42
DMI78_RS06190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMI78_RS06200	COG0006	proline dipeptidase activity
DMI78_RS06205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMI78_RS06215	COG5002	protein histidine kinase activity
DMI78_RS06220	COG0745	RESPONSE REGULATOR receiver
DMI78_RS06225	COG0129	dihydroxy-acid dehydratase activity
DMI78_RS06250	COG1368	sulfuric ester hydrolase activity
DMI78_RS06285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMI78_RS06290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMI78_RS06310	COG0534	Mate efflux family protein
DMI78_RS06315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMI78_RS06330	COG1876	peptidase activity
DMI78_RS06375	COG3209	COG3209 Rhs family protein
DMI78_RS06405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DMI78_RS06410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DMI78_RS06415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DMI78_RS06420	COG2205	protein histidine kinase activity
DMI78_RS06425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI78_RS06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI78_RS06445	COG0515	serine threonine protein kinase
DMI78_RS06450	COG0667	Aldo Keto reductase
DMI78_RS06455	COG0789	Transcriptional regulator
DMI78_RS06500	COG0714	Associated with various cellular activities
DMI78_RS06505	COG2311	Membrane
DMI78_RS06525	COG1090	epimerase
DMI78_RS06535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMI78_RS06540	COG1119	ATPase activity
DMI78_RS06545	COG2186	Transcriptional regulator
DMI78_RS06555	COG3119	arylsulfatase activity
DMI78_RS06565	COG0148	phosphopyruvate hydratase activity
DMI78_RS06570	COG0436	Aminotransferase
DMI78_RS06575	COG1477	protein flavinylation
DMI78_RS06590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMI78_RS06600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMI78_RS06620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMI78_RS06630	COG1199	ATP-dependent helicase activity
DMI78_RS06635	COG1122	ATPase activity
DMI78_RS06660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMI78_RS06665	COG0598	Magnesium transport protein CorA
DMI78_RS06670	COG0359	binds to the 23S rRNA
DMI78_RS06675	COG0138	bifunctional purine biosynthesis protein purh
DMI78_RS06680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DMI78_RS06685	COG0736	holo-[acyl-carrier-protein] synthase activity
DMI78_RS06695	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DMI78_RS06700	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMI78_RS06700	COG3409	Peptidoglycan-binding domain 1 protein
DMI78_RS06705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMI78_RS06715	COG0437	4 iron, 4 sulfur cluster binding
DMI78_RS06735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMI78_RS06790	COG0284	orotidine-5'-phosphate decarboxylase activity
DMI78_RS06810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMI78_RS06815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMI78_RS06835	COG2003	Belongs to the UPF0758 family
DMI78_RS06840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DMI78_RS06840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMI78_RS06845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMI78_RS06850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMI78_RS06855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMI78_RS06860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMI78_RS06865	COG0322	excinuclease ABC activity
DMI78_RS06870	COG0811	peptide transport
DMI78_RS06875	COG0848	biopolymer transport protein
DMI78_RS06885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DMI78_RS06890	COG0483	inositol monophosphate 1-phosphatase activity
DMI78_RS06895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DMI78_RS06905	COG1482	cell wall glycoprotein biosynthetic process
DMI78_RS06915	COG1757	Na H antiporter
DMI78_RS06920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI78_RS06925	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DMI78_RS06930	COG0505	Belongs to the CarA family
DMI78_RS06935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMI78_RS06945	COG0067	glutamate synthase
DMI78_RS06945	COG0070	glutamate synthase
DMI78_RS06945	COG0069	glutamate synthase activity
DMI78_RS06955	COG0706	membrane insertase activity
DMI78_RS06960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMI78_RS06970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DMI78_RS06980	COG0657	acetylesterase activity
DMI78_RS06980	COG2755	lipolytic protein G-D-S-L family
DMI78_RS06990	COG0676	glucose-6-phosphate 1-epimerase activity
DMI78_RS06995	COG0259	pyridoxamine-phosphate oxidase activity
DMI78_RS07010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMI78_RS07065	COG1760	l-serine dehydratase
DMI78_RS07070	COG0492	ferredoxin-NADP+ reductase activity
DMI78_RS07070	COG3118	belongs to the thioredoxin family
DMI78_RS07120	COG1408	metallophosphoesterase
DMI78_RS07130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMI78_RS07135	COG0545	Peptidyl-prolyl cis-trans isomerase
DMI78_RS07150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMI78_RS07160	COG0826	peptidase U32
DMI78_RS07165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DMI78_RS07195	COG0581	inorganic phosphate transmembrane transporter activity
DMI78_RS07200	COG0573	inorganic phosphate transmembrane transporter activity
DMI78_RS07210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMI78_RS07220	COG2017	converts alpha-aldose to the beta-anomer
DMI78_RS07235	COG0612	Peptidase, M16
DMI78_RS07285	COG0233	cytoplasmic translational termination
DMI78_RS07290	COG0528	UMP kinase activity
DMI78_RS07295	COG0668	transmembrane transport
DMI78_RS07300	COG0450	alkyl hydroperoxide reductase
DMI78_RS07305	COG0733	neurotransmitter:sodium symporter activity
DMI78_RS07320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMI78_RS07330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DMI78_RS07335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMI78_RS07340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMI78_RS07360	COG0842	Transport permease protein
DMI78_RS07365	COG0842	Transport permease protein
DMI78_RS07370	COG1131	(ABC) transporter
DMI78_RS07380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMI78_RS07385	COG1183	phosphatidylcholine synthase activity
DMI78_RS07395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMI78_RS07405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DMI78_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
DMI78_RS07430	COG0156	8-amino-7-oxononanoate synthase activity
DMI78_RS07450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMI78_RS07455	COG0124	histidyl-tRNA synthetase
DMI78_RS07460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMI78_RS07465	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DMI78_RS07470	COG0298	carbon dioxide binding
DMI78_RS07495	COG0438	transferase activity, transferring glycosyl groups
DMI78_RS07500	COG0443	Heat shock 70 kDa protein
DMI78_RS07505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMI78_RS07510	COG0459	protein refolding
DMI78_RS07560	COG0632	four-way junction helicase activity
DMI78_RS07570	COG0126	phosphoglycerate kinase activity
DMI78_RS07580	COG1082	Xylose isomerase domain protein TIM barrel
DMI78_RS07585	COG3064	Membrane
DMI78_RS07585	COG4991	sh3 domain protein
DMI78_RS07585	COG0515	serine threonine protein kinase
DMI78_RS07590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMI78_RS07600	COG2271	Major facilitator Superfamily
DMI78_RS07615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMI78_RS07625	COG0037	tRNA processing
DMI78_RS07630	COG0254	rRNA binding
DMI78_RS07665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DMI78_RS07670	COG0039	L-malate dehydrogenase activity
DMI78_RS07690	COG0778	Nitroreductase
DMI78_RS07695	COG0564	pseudouridine synthase activity
DMI78_RS07715	COG1126	abc transporter atp-binding protein
DMI78_RS07720	COG0765	amino acid transport
DMI78_RS07730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMI78_RS07735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMI78_RS07760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI78_RS07785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMI78_RS07790	COG1872	DUF167
DMI78_RS07795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMI78_RS07800	COG0484	heat shock protein binding
DMI78_RS07805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMI78_RS07815	COG5434	Belongs to the glycosyl hydrolase 28 family
DMI78_RS07830	COG0277	FAD linked oxidase domain protein
DMI78_RS07855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMI78_RS07860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMI78_RS07870	COG0131	Imidazoleglycerol-phosphate dehydratase
DMI78_RS07875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMI78_RS07880	COG0360	Binds together with S18 to 16S ribosomal RNA
DMI78_RS07885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DMI78_RS07900	COG1686	Belongs to the peptidase S11 family
DMI78_RS07905	COG0205	6-phosphofructokinase activity
DMI78_RS07915	COG0428	transporter
DMI78_RS07920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMI78_RS07940	COG3977	Valine--pyruvate aminotransferase
DMI78_RS07945	COG1561	YicC-like family, N-terminal region
DMI78_RS07955	COG0471	metal ion transport
DMI78_RS07955	COG3273	potassium ion transport
DMI78_RS07960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI78_RS07975	COG1575	Belongs to the MenA family. Type 1 subfamily
DMI78_RS08010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI78_RS08010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMI78_RS08030	COG0202	RNA polymerase activity
DMI78_RS08035	COG0203	ribosomal protein L17
DMI78_RS08040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DMI78_RS08045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI78_RS08060	COG2885	chlorophyll binding
DMI78_RS08115	COG0667	Aldo Keto reductase
DMI78_RS08120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DMI78_RS08135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI78_RS08140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMI78_RS08145	COG0134	indole-3-glycerol-phosphate synthase activity
DMI78_RS08150	COG0135	phosphoribosylanthranilate isomerase activity
DMI78_RS08160	COG0159	tryptophan synthase activity
DMI78_RS08175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMI78_RS08180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMI78_RS08190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMI78_RS08220	COG0561	phosphatase activity
DMI78_RS08225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI78_RS08230	COG2223	nitrite transmembrane transporter activity
DMI78_RS08245	COG0556	nucleotide-excision repair
DMI78_RS08250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMI78_RS08255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMI78_RS08275	COG1074	ATP-dependent DNA helicase activity
DMI78_RS08285	COG0697	spore germination
DMI78_RS08295	COG1002	Type II restriction enzyme, methylase subunits
DMI78_RS08300	COG1061	Type III restriction enzyme res subunit
DMI78_RS08305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMI78_RS08310	COG2373	Large extracellular alpha-helical protein
DMI78_RS08315	COG1979	alcohol dehydrogenase
DMI78_RS08325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMI78_RS08350	COG0372	Belongs to the citrate synthase family
DMI78_RS08365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMI78_RS08375	COG1187	pseudouridine synthase activity
DMI78_RS08385	COG0105	UTP biosynthetic process
DMI78_RS08390	COG1215	transferase activity, transferring glycosyl groups
DMI78_RS08395	COG0463	Glycosyl transferase, family 2
DMI78_RS08405	COG1459	type II secretion system
DMI78_RS08410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI78_RS08415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMI78_RS08420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI78_RS08435	COG0728	peptidoglycan biosynthetic process
DMI78_RS08440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI78_RS08440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DMI78_RS08450	COG1649	PFAM Uncharacterised BCR, COG1649
DMI78_RS08455	COG1691	(AIR) carboxylase
DMI78_RS08460	COG0482	sulfurtransferase activity
DMI78_RS08465	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMI78_RS08470	COG0142	geranyltranstransferase activity
DMI78_RS08485	COG2151	metal-sulfur cluster biosynthetic enzyme
DMI78_RS08505	COG1007	ATP synthesis coupled electron transport
DMI78_RS08510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI78_RS08520	COG0713	ATP synthesis coupled electron transport
DMI78_RS08525	COG0839	Belongs to the complex I subunit 6 family
DMI78_RS08535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DMI78_RS08540	COG1034	ATP synthesis coupled electron transport
DMI78_RS08545	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DMI78_RS08550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DMI78_RS08555	COG0649	NAD binding
DMI78_RS08565	COG0726	polysaccharide deacetylase
DMI78_RS08575	COG0307	riboflavin synthase, alpha
DMI78_RS08580	COG2264	protein methyltransferase activity
DMI78_RS08585	COG3210	domain, Protein
DMI78_RS08590	COG1640	4-alpha-glucanotransferase
DMI78_RS08600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMI78_RS08605	COG1030	water channel activity
DMI78_RS08610	COG0358	DNA primase activity
DMI78_RS08615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMI78_RS08620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DMI78_RS08635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMI78_RS08640	COG0793	Belongs to the peptidase S41A family
DMI78_RS08650	COG1643	Atp-dependent helicase
DMI78_RS08675	COG1450	Type ii and iii secretion system protein
DMI78_RS08690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMI78_RS08710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMI78_RS08715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DMI78_RS08725	COG0268	Binds directly to 16S ribosomal RNA
DMI78_RS08730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMI78_RS08735	COG0028	Belongs to the TPP enzyme family
DMI78_RS08740	COG0305	Participates in initiation and elongation during chromosome replication
DMI78_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMI78_RS09140	COG0688	phosphatidylethanolamine metabolic process
DMI78_RS09145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMI78_RS09150	COG0495	leucyl-tRNA aminoacylation
DMI78_RS09155	COG3119	arylsulfatase activity
DMI78_RS09170	COG1166	arginine decarboxylase activity
DMI78_RS09180	COG3250	beta-galactosidase activity
DMI78_RS09185	COG3250	beta-galactosidase activity
DMI78_RS09190	COG3250	beta-galactosidase activity
DMI78_RS09195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMI78_RS09200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS09210	COG0205	6-phosphofructokinase activity
DMI78_RS09245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DMI78_RS09250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DMI78_RS09255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DMI78_RS09265	COG4771	TonB-dependent receptor
DMI78_RS09285	COG0402	S-adenosylhomocysteine deaminase activity
DMI78_RS09290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMI78_RS09315	COG1294	oxidase, subunit
DMI78_RS09320	COG1271	oxidase subunit
DMI78_RS09330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMI78_RS09350	COG1846	Transcriptional regulator
DMI78_RS09375	COG2949	membrane
DMI78_RS09405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMI78_RS09585	COG0514	ATP-dependent DNA helicase (RecQ)
DMI78_RS09760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMI78_RS09765	COG0045	succinate-CoA ligase (ADP-forming) activity
DMI78_RS09770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMI78_RS09830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMI78_RS09835	COG2205	protein histidine kinase activity
DMI78_RS09850	COG0113	porphobilinogen synthase activity
DMI78_RS09860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMI78_RS09880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DMI78_RS09920	COG3475	LICD family
DMI78_RS09925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMI78_RS09935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI78_RS09940	COG3475	LICD family
DMI78_RS09945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DMI78_RS09955	COG2166	iron-sulfur cluster assembly
DMI78_RS09960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMI78_RS09970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI78_RS09975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMI78_RS09980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMI78_RS09985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMI78_RS09990	COG1131	(ABC) transporter
DMI78_RS10005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMI78_RS10020	COG1215	transferase activity, transferring glycosyl groups
DMI78_RS10030	COG2967	ApaG domain
DMI78_RS10040	COG1522	sequence-specific DNA binding
DMI78_RS10045	COG0436	Aminotransferase
DMI78_RS10060	COG0423	glycine-tRNA ligase activity
DMI78_RS10065	COG0656	L-ascorbic acid biosynthetic process
DMI78_RS10080	COG2304	oxidoreductase activity
DMI78_RS10095	COG0714	Associated with various cellular activities
DMI78_RS10100	COG0154	amidase activity
DMI78_RS10105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMI78_RS10145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI78_RS10155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI78_RS10155	COG2755	lipolytic protein G-D-S-L family
DMI78_RS10175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI78_RS10185	COG0656	L-ascorbic acid biosynthetic process
DMI78_RS10195	COG0667	Aldo Keto reductase
DMI78_RS10200	COG1408	metallophosphoesterase
DMI78_RS10220	COG2249	NAD(P)H dehydrogenase (quinone) activity
DMI78_RS10225	COG0789	Transcriptional regulator
DMI78_RS10240	COG0534	Mate efflux family protein
DMI78_RS10260	COG1091	dTDP-4-dehydrorhamnose reductase activity
DMI78_RS10275	COG1837	Belongs to the UPF0109 family
DMI78_RS10280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI78_RS10285	COG0363	glucosamine-6-phosphate deaminase activity
DMI78_RS10305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DMI78_RS10315	COG1741	Belongs to the pirin family
DMI78_RS10330	COG1070	Carbohydrate kinase
DMI78_RS10345	COG0738	Major facilitator superfamily
DMI78_RS10360	COG1595	DNA-templated transcription, initiation
DMI78_RS10375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMI78_RS10400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMI78_RS10410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DMI78_RS10415	COG2132	Multicopper oxidase
DMI78_RS10420	COG0697	spore germination
DMI78_RS10425	COG3586	endonuclease activity
DMI78_RS10435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI78_RS10440	COG4608	Belongs to the ABC transporter superfamily
DMI78_RS10445	COG0444	Belongs to the ABC transporter superfamily
DMI78_RS10450	COG4166	transmembrane transport
DMI78_RS10455	COG4239	(ABC) transporter, permease
DMI78_RS10460	COG0601	transmembrane transport
DMI78_RS10480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMI78_RS10485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMI78_RS10490	COG3738	Protein conserved in bacteria
DMI78_RS10495	COG0151	Belongs to the GarS family
DMI78_RS10510	COG0811	peptide transport
DMI78_RS10520	COG0242	peptide deformylase activity
DMI78_RS10555	COG2010	Cytochrome c
DMI78_RS10565	COG3258	Cytochrome c
DMI78_RS10580	COG3274	enterobacterial common antigen metabolic process
DMI78_RS10585	COG0538	isocitrate dehydrogenase activity
DMI78_RS10600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DMI78_RS10605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMI78_RS10610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMI78_RS10620	COG0668	transmembrane transport
DMI78_RS10625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMI78_RS10625	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DMI78_RS10630	COG0805	protein transport
DMI78_RS10635	COG1968	undecaprenyl-diphosphatase activity
DMI78_RS10655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMI78_RS10665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMI78_RS10675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMI78_RS10685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMI78_RS10695	COG1408	metallophosphoesterase
DMI78_RS10720	COG4974	Belongs to the 'phage' integrase family
DMI78_RS10740	COG1454	alcohol dehydrogenase
DMI78_RS10745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMI78_RS10755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DMI78_RS10755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMI78_RS10760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DMI78_RS10800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI78_RS10810	COG4607	ABC-type enterochelin transport system periplasmic component
DMI78_RS10815	COG4604	ABC transporter, ATP-binding protein
DMI78_RS10820	COG4605	iron ion homeostasis
DMI78_RS10825	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMI78_RS10860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI78_RS10860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMI78_RS10875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMI78_RS10880	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMI78_RS10900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMI78_RS10920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMI78_RS10945	COG0519	Catalyzes the synthesis of GMP from XMP
DMI78_RS10945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMI78_RS10950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMI78_RS10980	COG0646	methionine synthase
DMI78_RS10980	COG1410	methionine synthase
DMI78_RS10985	COG2966	Psort location CytoplasmicMembrane, score
DMI78_RS10990	COG3610	response to peptide
DMI78_RS10995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DMI78_RS11015	COG3177	Filamentation induced by cAMP protein fic
DMI78_RS11020	COG4974	Belongs to the 'phage' integrase family
DMI78_RS11030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMI78_RS11040	COG0460	homoserine dehydrogenase
DMI78_RS11045	COG0527	aspartate kinase activity
DMI78_RS11055	COG5522	Integral membrane protein (intg_mem_TP0381)
DMI78_RS11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMI78_RS11075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMI78_RS11080	COG1194	a g-specific adenine glycosylase
DMI78_RS11085	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DMI78_RS11090	COG0574	Belongs to the PEP-utilizing enzyme family
DMI78_RS11090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMI78_RS11095	COG0166	Belongs to the GPI family
DMI78_RS11105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMI78_RS11115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI78_RS11115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DMI78_RS11150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMI78_RS11155	COG2818	Glycosylase
DMI78_RS11175	COG3033	Beta-eliminating lyase
DMI78_RS11190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI78_RS11190	COG0072	phenylalanine-tRNA ligase activity
DMI78_RS11210	COG0326	Molecular chaperone. Has ATPase activity
DMI78_RS11215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMI78_RS11225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMI78_RS11230	COG1959	2 iron, 2 sulfur cluster binding
DMI78_RS11245	COG0352	thiamine-phosphate diphosphorylase activity
DMI78_RS11250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMI78_RS11275	COG1703	isobutyryl-CoA mutase activity
DMI78_RS11295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DMI78_RS11305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMI78_RS11310	COG0418	dihydroorotase activity
DMI78_RS11325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI78_RS11345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMI78_RS11360	COG0534	Mate efflux family protein
DMI78_RS11365	COG0489	protein tyrosine kinase activity
DMI78_RS11375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMI78_RS11380	COG0339	signal peptide processing
DMI78_RS11385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMI78_RS11395	COG1538	Outer membrane efflux protein
DMI78_RS11410	COG4112	unkown
DMI78_RS11425	COG0038	chloride channel
DMI78_RS11445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DMI78_RS11450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DMI78_RS11455	COG0586	Pfam SNARE associated Golgi protein
DMI78_RS11520	COG1518	maintenance of DNA repeat elements
DMI78_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
DMI78_RS11570	COG0753	catalase activity
DMI78_RS11580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMI78_RS11585	COG1592	Rubrerythrin
DMI78_RS11590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMI78_RS11610	COG0489	protein tyrosine kinase activity
DMI78_RS11620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMI78_RS11630	COG2244	polysaccharide biosynthetic process
DMI78_RS11635	COG1215	transferase activity, transferring glycosyl groups
DMI78_RS11645	COG1216	Glycosyl transferase, family 2
DMI78_RS11655	COG0438	transferase activity, transferring glycosyl groups
DMI78_RS11660	COG0438	transferase activity, transferring glycosyl groups
DMI78_RS11690	COG1216	Glycosyl transferase, family 2
DMI78_RS11710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMI78_RS11710	COG2755	lipolytic protein G-D-S-L family
DMI78_RS11730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DMI78_RS11735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI78_RS11735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMI78_RS11740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMI78_RS11750	COG0281	malic enzyme
DMI78_RS11750	COG0280	phosphate acetyltransferase
DMI78_RS11765	COG1472	Belongs to the glycosyl hydrolase 3 family
DMI78_RS11770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMI78_RS11785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMI78_RS11795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMI78_RS11800	COG1063	alcohol dehydrogenase
DMI78_RS11815	COG0714	Associated with various cellular activities
DMI78_RS11825	COG0193	aminoacyl-tRNA hydrolase activity
DMI78_RS11830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMI78_RS11850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMI78_RS11870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DMI78_RS11885	COG0375	protein maturation
DMI78_RS11910	COG0778	Nitroreductase
DMI78_RS11915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMI78_RS11940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI78_RS11940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DMI78_RS11960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DMI78_RS11965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMI78_RS11970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DMI78_RS12015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI78_RS12020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DMI78_RS12035	COG0318	PFAM AMP-dependent synthetase and ligase
DMI78_RS12060	COG0339	signal peptide processing
DMI78_RS12070	COG0018	arginyl-trna synthetase
DMI78_RS12115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMI78_RS12120	COG0653	protein targeting
DMI78_RS12135	COG0494	nUDIX hydrolase
DMI78_RS12140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters