locus-tag	class	description
DFS30_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DFS30_RS00010	COG1131	(ABC) transporter
DFS30_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DFS30_RS00035	COG0564	pseudouridine synthase activity
DFS30_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DFS30_RS00055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DFS30_RS00065	COG0513	Belongs to the DEAD box helicase family
DFS30_RS00075	COG0673	inositol 2-dehydrogenase activity
DFS30_RS00110	COG1971	Probably functions as a manganese efflux pump
DFS30_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFS30_RS00160	COG0442	prolyl-tRNA aminoacylation
DFS30_RS00205	COG0531	amino acid
DFS30_RS00210	COG2066	Belongs to the glutaminase family
DFS30_RS00225	COG1115	amino acid carrier protein
DFS30_RS00235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DFS30_RS00240	COG2890	protein-(glutamine-N5) methyltransferase activity
DFS30_RS00245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DFS30_RS00250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DFS30_RS00265	COG2226	methyltransferase
DFS30_RS00270	COG0534	Mate efflux family protein
DFS30_RS00310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFS30_RS00315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DFS30_RS00320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS00335	COG1121	(ABC) transporter
DFS30_RS00340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DFS30_RS00345	COG3880	PFAM UvrB UvrC protein
DFS30_RS00350	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DFS30_RS00355	COG0542	response to heat
DFS30_RS00365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DFS30_RS00370	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFS30_RS00375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFS30_RS00390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DFS30_RS00390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DFS30_RS00400	COG0180	Tryptophanyl-tRNA synthetase
DFS30_RS00410	COG1692	metallophosphoesterase
DFS30_RS00415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DFS30_RS00475	COG0515	serine threonine protein kinase
DFS30_RS00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFS30_RS00585	COG2816	NAD+ diphosphatase activity
DFS30_RS00590	COG0156	8-amino-7-oxononanoate synthase activity
DFS30_RS00605	COG0515	serine threonine protein kinase
DFS30_RS00605	COG3266	domain, Protein
DFS30_RS00645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DFS30_RS00655	COG3189	MarR family transcriptional regulator
DFS30_RS00665	COG0181	hydroxymethylbilane synthase activity
DFS30_RS00670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DFS30_RS00680	COG1469	GTP cyclohydrolase I activity
DFS30_RS00685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DFS30_RS00690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DFS30_RS00700	COG1940	carbohydrate kinase activity
DFS30_RS00715	COG0494	nUDIX hydrolase
DFS30_RS00720	COG1566	PFAM secretion protein HlyD family protein
DFS30_RS00725	COG1136	(ABC) transporter
DFS30_RS00725	COG0577	efflux transmembrane transporter activity
DFS30_RS00730	COG1136	(ABC) transporter
DFS30_RS00730	COG0577	efflux transmembrane transporter activity
DFS30_RS00735	COG1538	Outer membrane efflux protein
DFS30_RS00750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DFS30_RS00790	COG1720	tRNA m6t6A37 methyltransferase activity
DFS30_RS00795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DFS30_RS00800	COG0540	Belongs to the ATCase OTCase family
DFS30_RS00805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DFS30_RS00820	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DFS30_RS00825	COG2957	Belongs to the agmatine deiminase family
DFS30_RS00835	COG0750	zinc metalloprotease
DFS30_RS00845	COG3119	arylsulfatase activity
DFS30_RS00855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DFS30_RS00855	COG1918	ferrous iron import across plasma membrane
DFS30_RS00905	COG1475	DNA binding
DFS30_RS00940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DFS30_RS00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFS30_RS00960	COG0601	transmembrane transport
DFS30_RS01010	COG0849	cell division
DFS30_RS01020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DFS30_RS01025	COG1132	(ABC) transporter
DFS30_RS01030	COG1132	(ABC) transporter
DFS30_RS01045	COG1127	ABC transporter
DFS30_RS01050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DFS30_RS01080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DFS30_RS01095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DFS30_RS01100	COG0504	CTP synthase activity
DFS30_RS01105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DFS30_RS01130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DFS30_RS01140	COG1322	Protein conserved in bacteria
DFS30_RS01145	COG0546	phosphoglycolate phosphatase activity
DFS30_RS01150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DFS30_RS01160	COG4591	ABC-type transport system involved in lipoprotein release permease component
DFS30_RS01160	COG4591	ABC-type transport system involved in lipoprotein release permease component
DFS30_RS01165	COG3209	COG3209 Rhs family protein
DFS30_RS01165	COG4104	PAAR repeat-containing protein
DFS30_RS01180	COG3209	COG3209 Rhs family protein
DFS30_RS01190	COG3209	COG3209 Rhs family protein
DFS30_RS01230	COG2234	aminopeptidase activity
DFS30_RS01235	COG2755	lipolytic protein G-D-S-L family
DFS30_RS01235	COG0657	acetylesterase activity
DFS30_RS01240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DFS30_RS01260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DFS30_RS01275	COG0335	large ribosomal subunit rRNA binding
DFS30_RS01285	COG0346	lactoylglutathione lyase activity
DFS30_RS01300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DFS30_RS01305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DFS30_RS01315	COG0427	acetyl-CoA hydrolase
DFS30_RS01325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DFS30_RS01335	COG0205	6-phosphofructokinase activity
DFS30_RS01345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFS30_RS01350	COG0028	Belongs to the TPP enzyme family
DFS30_RS01370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DFS30_RS01385	COG0471	metal ion transport
DFS30_RS01395	COG0351	phosphomethylpyrimidine kinase
DFS30_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
DFS30_RS01455	COG0242	peptide deformylase activity
DFS30_RS01460	COG1063	alcohol dehydrogenase
DFS30_RS01470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DFS30_RS01475	COG1393	Belongs to the ArsC family
DFS30_RS01480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFS30_RS01490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DFS30_RS01500	COG1187	pseudouridine synthase activity
DFS30_RS01510	COG0336	Belongs to the RNA methyltransferase TrmD family
DFS30_RS01525	COG0539	negative regulation of cytoplasmic translation
DFS30_RS01570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DFS30_RS01575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DFS30_RS01580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DFS30_RS01585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFS30_RS01620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DFS30_RS01640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DFS30_RS01640	COG0662	Cupin 2, conserved barrel domain protein
DFS30_RS01650	COG0416	fatty acid biosynthetic process
DFS30_RS01655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DFS30_RS01665	COG0537	adenosine 5'-monophosphoramidase activity
DFS30_RS01670	COG0009	L-threonylcarbamoyladenylate synthase
DFS30_RS01675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DFS30_RS01680	COG0228	four-way junction DNA binding
DFS30_RS01705	COG1862	Preprotein translocase
DFS30_RS01710	COG0343	queuine tRNA-ribosyltransferase activity
DFS30_RS01715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DFS30_RS01725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DFS30_RS01730	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DFS30_RS01735	COG0776	regulation of translation
DFS30_RS01765	COG0811	peptide transport
DFS30_RS01780	COG3250	beta-galactosidase activity
DFS30_RS01785	COG0525	valine-tRNA ligase activity
DFS30_RS01795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DFS30_RS01800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DFS30_RS01805	COG0255	Belongs to the universal ribosomal protein uL29 family
DFS30_RS01810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DFS30_RS01815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DFS30_RS01820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DFS30_RS01830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DFS30_RS01835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DFS30_RS01840	COG0089	rRNA binding
DFS30_RS01845	COG0088	Forms part of the polypeptide exit tunnel
DFS30_RS01850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DFS30_RS01855	COG0051	transcription antitermination factor activity, RNA binding
DFS30_RS01860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DFS30_RS01865	COG0049	tRNA binding
DFS30_RS01870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DFS30_RS01875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DFS30_RS01885	COG3852	Histidine kinase
DFS30_RS01890	COG2204	response regulator
DFS30_RS01900	COG1722	exodeoxyribonuclease VII activity
DFS30_RS01905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DFS30_RS01920	COG0795	lipopolysaccharide-transporting ATPase activity
DFS30_RS01925	COG1160	GTP binding
DFS30_RS01930	COG0444	Belongs to the ABC transporter superfamily
DFS30_RS01945	COG1136	(ABC) transporter
DFS30_RS01945	COG0577	efflux transmembrane transporter activity
DFS30_RS01955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DFS30_RS02000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DFS30_RS02005	COG0799	negative regulation of ribosome biogenesis
DFS30_RS02010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFS30_RS02060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DFS30_RS02075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DFS30_RS02085	COG4221	oxidoreductase activity
DFS30_RS02105	COG0038	chloride channel
DFS30_RS02115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS02130	COG0076	glutamate decarboxylase activity
DFS30_RS02145	COG0167	dihydroorotate dehydrogenase activity
DFS30_RS02150	COG0352	thiamine-phosphate diphosphorylase activity
DFS30_RS02170	COG1253	flavin adenine dinucleotide binding
DFS30_RS02175	COG1253	flavin adenine dinucleotide binding
DFS30_RS02180	COG1185	polyribonucleotide nucleotidyltransferase activity
DFS30_RS02185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DFS30_RS02215	COG0101	tRNA pseudouridine synthase activity
DFS30_RS02220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DFS30_RS02235	COG4968	Prepilin-type N-terminal cleavage methylation domain
DFS30_RS02250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS02255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DFS30_RS02275	COG1136	(ABC) transporter
DFS30_RS02280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DFS30_RS02290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DFS30_RS02300	COG1116	anion transmembrane transporter activity
DFS30_RS02315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS02325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DFS30_RS02330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DFS30_RS02340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DFS30_RS02345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFS30_RS02355	COG2814	Major facilitator Superfamily
DFS30_RS02365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DFS30_RS02370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFS30_RS02370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFS30_RS02375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DFS30_RS02380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DFS30_RS02385	COG0552	protein localization to endoplasmic reticulum
DFS30_RS02390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DFS30_RS02410	COG1546	Belongs to the CinA family
DFS30_RS02410	COG1058	Belongs to the CinA family
DFS30_RS02420	COG0456	acetyltransferase
DFS30_RS02445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DFS30_RS02450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DFS30_RS02455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFS30_RS02460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DFS30_RS02475	COG0758	DNA mediated transformation
DFS30_RS02480	COG1686	Belongs to the peptidase S11 family
DFS30_RS02485	COG0012	GTP binding
DFS30_RS02490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DFS30_RS02500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFS30_RS02500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFS30_RS02515	COG3119	arylsulfatase activity
DFS30_RS02540	COG2259	Doxx family
DFS30_RS02545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DFS30_RS02575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFS30_RS02595	COG2326	polyphosphate kinase activity
DFS30_RS02600	COG1349	DNA-binding transcription factor activity
DFS30_RS02625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFS30_RS02630	COG1162	GTPase activity
DFS30_RS02645	COG0742	ribosomal rna small subunit methyltransferase
DFS30_RS02660	COG2326	polyphosphate kinase activity
DFS30_RS02670	COG5434	Belongs to the glycosyl hydrolase 28 family
DFS30_RS02680	COG1073	alpha beta
DFS30_RS02685	COG0802	atpase or kinase
DFS30_RS02690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DFS30_RS02695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DFS30_RS02700	COG0735	belongs to the Fur family
DFS30_RS02705	COG0396	ATPase activity
DFS30_RS02710	COG0719	Fe-S assembly protein
DFS30_RS02715	COG0719	Fe-S assembly protein
DFS30_RS02730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFS30_RS02775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DFS30_RS02795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DFS30_RS02800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DFS30_RS02805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DFS30_RS02810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DFS30_RS02815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DFS30_RS02820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DFS30_RS02830	COG0356	it plays a direct role in the translocation of protons across the membrane
DFS30_RS02885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DFS30_RS02920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DFS30_RS02925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DFS30_RS02930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DFS30_RS02940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DFS30_RS02950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DFS30_RS02955	COG0047	phosphoribosylformylglycinamidine synthase activity
DFS30_RS02965	COG1363	Peptidase, m42
DFS30_RS02980	COG1077	Cell shape determining protein MreB Mrl
DFS30_RS02985	COG1530	ribonuclease E activity
DFS30_RS03005	COG0848	biopolymer transport protein
DFS30_RS03020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DFS30_RS03035	COG0134	indole-3-glycerol-phosphate synthase activity
DFS30_RS03040	COG0792	nuclease activity
DFS30_RS03050	COG1253	flavin adenine dinucleotide binding
DFS30_RS03060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DFS30_RS03065	COG0137	argininosuccinate synthase activity
DFS30_RS03080	COG0149	triose-phosphate isomerase activity
DFS30_RS03115	COG1040	competence protein
DFS30_RS03125	COG3956	TIGRFAM MazG family protein
DFS30_RS03145	COG1663	tetraacyldisaccharide 4'-kinase activity
DFS30_RS03155	COG0612	Peptidase, M16
DFS30_RS03170	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DFS30_RS03200	COG0673	inositol 2-dehydrogenase activity
DFS30_RS03205	COG3034	peptidoglycan biosynthetic process
DFS30_RS03225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DFS30_RS03230	COG0424	maF-like protein
DFS30_RS03235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DFS30_RS03265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DFS30_RS03275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFS30_RS03285	COG0571	ribonuclease III activity
DFS30_RS03305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DFS30_RS03320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DFS30_RS03340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DFS30_RS03350	COG2226	methyltransferase
DFS30_RS03360	COG2076	Multidrug Resistance protein
DFS30_RS03385	COG2255	four-way junction helicase activity
DFS30_RS03390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFS30_RS03395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DFS30_RS03400	COG1215	transferase activity, transferring glycosyl groups
DFS30_RS03405	COG0463	Glycosyl transferase, family 2
DFS30_RS03405	COG1216	Glycosyl transferase, family 2
DFS30_RS03430	COG0438	transferase activity, transferring glycosyl groups
DFS30_RS03440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DFS30_RS03450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DFS30_RS03460	COG0482	sulfurtransferase activity
DFS30_RS03465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DFS30_RS03475	COG2860	membrane
DFS30_RS03480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFS30_RS03485	COG2001	Belongs to the MraZ family
DFS30_RS03490	COG0275	rRNA processing
DFS30_RS03500	COG0768	penicillin binding
DFS30_RS03505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DFS30_RS03510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DFS30_RS03515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DFS30_RS03520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DFS30_RS03530	COG0772	Belongs to the SEDS family
DFS30_RS03535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DFS30_RS03540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DFS30_RS03545	COG1181	Belongs to the D-alanine--D-alanine ligase family
DFS30_RS03555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DFS30_RS03560	COG0860	N-Acetylmuramoyl-L-alanine amidase
DFS30_RS03565	COG0321	lipoyl(octanoyl) transferase activity
DFS30_RS03570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DFS30_RS03575	COG0066	3-isopropylmalate dehydratase activity
DFS30_RS03585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DFS30_RS03595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFS30_RS03600	COG4608	Belongs to the ABC transporter superfamily
DFS30_RS03605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DFS30_RS03610	COG0052	Belongs to the universal ribosomal protein uS2 family
DFS30_RS03620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DFS30_RS03635	COG1137	ATPase activity
DFS30_RS03645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DFS30_RS03660	COG1733	regulation of RNA biosynthetic process
DFS30_RS03670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DFS30_RS03715	COG0017	Asparaginyl-tRNA synthetase
DFS30_RS03725	COG3118	belongs to the thioredoxin family
DFS30_RS03770	COG0583	DNA-binding transcription factor activity
DFS30_RS03775	COG2855	membrane
DFS30_RS03780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DFS30_RS03790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DFS30_RS03800	COG0602	queuosine metabolic process
DFS30_RS03805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DFS30_RS03810	COG0217	transcriptional regulatory protein
DFS30_RS03815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DFS30_RS03820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DFS30_RS03820	COG4651	solute:proton antiporter activity
DFS30_RS03835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DFS30_RS03840	COG4864	UPF0365 protein
DFS30_RS03850	COG2022	thiamine diphosphate biosynthetic process
DFS30_RS03855	COG0531	amino acid
DFS30_RS03865	COG0628	permease
DFS30_RS03870	COG0019	diaminopimelate decarboxylase activity
DFS30_RS03875	COG0191	fructose-bisphosphate aldolase activity
DFS30_RS03880	COG1217	gtp-binding protein TYPA
DFS30_RS03910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFS30_RS03950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DFS30_RS03955	COG0516	GMP reductase activity
DFS30_RS03955	COG0517	IMP dehydrogenase activity
DFS30_RS03960	COG0519	Catalyzes the synthesis of GMP from XMP
DFS30_RS03960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFS30_RS03965	COG1196	nuclear chromosome segregation
DFS30_RS03975	COG0546	phosphoglycolate phosphatase activity
DFS30_RS04000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DFS30_RS04015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DFS30_RS04020	COG0196	riboflavin kinase activity
DFS30_RS04025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFS30_RS04040	COG1408	metallophosphoesterase
DFS30_RS04050	COG1216	Glycosyl transferase, family 2
DFS30_RS04050	COG1442	glycosyl transferase family 8
DFS30_RS04060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFS30_RS04065	COG1216	Glycosyl transferase, family 2
DFS30_RS04085	COG2755	lipolytic protein G-D-S-L family
DFS30_RS04085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DFS30_RS04100	COG0490	domain, Protein
DFS30_RS04100	COG0471	metal ion transport
DFS30_RS04135	COG0588	phosphoglycerate mutase activity
DFS30_RS04140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFS30_RS04150	COG0477	Major facilitator Superfamily
DFS30_RS04155	COG1607	acyl-coa hydrolase
DFS30_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
DFS30_RS04175	COG1525	nuclease
DFS30_RS04190	COG1475	DNA binding
DFS30_RS04195	COG3969	phosphoadenosine phosphosulfate
DFS30_RS04210	COG0473	3-isopropylmalate dehydrogenase activity
DFS30_RS04235	COG2873	o-acetylhomoserine
DFS30_RS04240	COG0535	radical SAM domain protein
DFS30_RS04245	COG0535	radical SAM domain protein
DFS30_RS04260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DFS30_RS04265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DFS30_RS04275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DFS30_RS04280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFS30_RS04280	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFS30_RS04280	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFS30_RS04280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DFS30_RS04290	COG1733	regulation of RNA biosynthetic process
DFS30_RS04300	COG0107	imidazoleglycerol-phosphate synthase activity
DFS30_RS04305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DFS30_RS04315	COG1643	Atp-dependent helicase
DFS30_RS04320	COG0440	acetolactate synthase activity
DFS30_RS04325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DFS30_RS04335	COG0445	tRNA wobble uridine modification
DFS30_RS04340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFS30_RS04340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFS30_RS04345	COG0592	DNA-directed DNA polymerase activity
DFS30_RS04370	COG1388	LysM domain
DFS30_RS04370	COG0791	NLP P60 protein
DFS30_RS04375	COG0084	hydrolase, TatD family'
DFS30_RS04385	COG3250	beta-galactosidase activity
DFS30_RS04400	COG2205	protein histidine kinase activity
DFS30_RS04405	COG0745	RESPONSE REGULATOR receiver
DFS30_RS04415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DFS30_RS04440	COG0542	response to heat
DFS30_RS04485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DFS30_RS04495	COG0659	secondary active sulfate transmembrane transporter activity
DFS30_RS04500	COG0165	Argininosuccinate lyase
DFS30_RS04515	COG0148	phosphopyruvate hydratase activity
DFS30_RS04520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DFS30_RS04535	COG3481	metal-dependent phosphohydrolase, HD sub domain
DFS30_RS04545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFS30_RS04550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DFS30_RS04595	COG3345	alpha-galactosidase
DFS30_RS04620	COG0490	domain, Protein
DFS30_RS04620	COG2985	domain, Protein
DFS30_RS04635	COG0471	metal ion transport
DFS30_RS04660	COG2194	sulfuric ester hydrolase activity
DFS30_RS04665	COG1592	Rubrerythrin
DFS30_RS04675	COG1363	Peptidase, m42
DFS30_RS04680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS04690	COG1785	Belongs to the alkaline phosphatase family
DFS30_RS04695	COG1970	mechanosensitive ion channel activity
DFS30_RS04700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFS30_RS04710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DFS30_RS04720	COG2217	Heavy metal translocating P-type atpase
DFS30_RS04725	COG0497	DNA recombination
DFS30_RS04730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DFS30_RS04730	COG0321	lipoyl(octanoyl) transferase activity
DFS30_RS04735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DFS30_RS04765	COG0508	dehydrogenase complex catalyzes the overall conversion of
DFS30_RS04770	COG0022	dehydrogenase e1 component
DFS30_RS04775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DFS30_RS04780	COG0789	Transcriptional regulator
DFS30_RS04785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DFS30_RS04790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DFS30_RS04795	COG3210	domain, Protein
DFS30_RS04845	COG3409	Peptidoglycan-binding domain 1 protein
DFS30_RS04845	COG5632	N-Acetylmuramoyl-L-alanine amidase
DFS30_RS04850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DFS30_RS04875	COG1690	Belongs to the RtcB family
DFS30_RS04885	COG2814	Major facilitator Superfamily
DFS30_RS04895	COG2096	Adenosyltransferase
DFS30_RS04905	COG0557	exoribonuclease II activity
DFS30_RS04930	COG0826	peptidase U32
DFS30_RS04935	COG0285	dihydrofolate synthase activity
DFS30_RS04950	COG0673	inositol 2-dehydrogenase activity
DFS30_RS04955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFS30_RS04960	COG0737	Belongs to the 5'-nucleotidase family
DFS30_RS04970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DFS30_RS04975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DFS30_RS04990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DFS30_RS04995	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DFS30_RS05000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DFS30_RS05005	COG0200	Binds to the 23S rRNA
DFS30_RS05010	COG0201	protein transport
DFS30_RS05015	COG0563	adenylate kinase activity
DFS30_RS05020	COG0024	Methionine aminopeptidase
DFS30_RS05035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DFS30_RS05040	COG1442	glycosyl transferase family 8
DFS30_RS05050	COG1216	Glycosyl transferase, family 2
DFS30_RS05060	COG1216	Glycosyl transferase, family 2
DFS30_RS05070	COG1216	Glycosyl transferase, family 2
DFS30_RS05075	COG0693	protein deglycase activity
DFS30_RS05080	COG0508	dehydrogenase complex catalyzes the overall conversion of
DFS30_RS05085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DFS30_RS05090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DFS30_RS05100	COG1966	Carbon starvation protein
DFS30_RS05110	COG3119	arylsulfatase activity
DFS30_RS05115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DFS30_RS05120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DFS30_RS05125	COG0195	Participates in both transcription termination and antitermination
DFS30_RS05130	COG0708	Exodeoxyribonuclease III
DFS30_RS05135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DFS30_RS05140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DFS30_RS05145	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DFS30_RS05155	COG1131	(ABC) transporter
DFS30_RS05155	COG0842	Transport permease protein
DFS30_RS05155	COG1716	ATPase activity
DFS30_RS05175	COG0724	RNA recognition motif
DFS30_RS05180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DFS30_RS05200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DFS30_RS05210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DFS30_RS05215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DFS30_RS05230	COG1490	D-aminoacyl-tRNA deacylase activity
DFS30_RS05240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DFS30_RS05245	COG1053	succinate dehydrogenase
DFS30_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
DFS30_RS05300	COG0488	(ABC) transporter
DFS30_RS05310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DFS30_RS05320	COG1253	flavin adenine dinucleotide binding
DFS30_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
DFS30_RS05335	COG1073	alpha beta
DFS30_RS05345	COG0667	Aldo Keto reductase
DFS30_RS05400	COG2267	carboxylic ester hydrolase activity
DFS30_RS05405	COG2095	MarC family integral membrane protein
DFS30_RS05435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DFS30_RS05440	COG0488	(ABC) transporter
DFS30_RS05510	COG0215	cysteine-tRNA ligase activity
DFS30_RS05520	COG3119	arylsulfatase activity
DFS30_RS05535	COG0481	GTPase activity
DFS30_RS05555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFS30_RS05560	COG0085	RNA polymerase activity
DFS30_RS05565	COG0222	ribosome binding
DFS30_RS05570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DFS30_RS05575	COG0081	regulation of translation
DFS30_RS05580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DFS30_RS05585	COG0250	Participates in transcription elongation, termination and antitermination
DFS30_RS05600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DFS30_RS05610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DFS30_RS05620	COG0740	serine-type endopeptidase activity
DFS30_RS05625	COG0544	peptidyl-prolyl cis-trans isomerase activity
DFS30_RS05640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DFS30_RS05660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DFS30_RS05705	COG2226	methyltransferase
DFS30_RS05710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DFS30_RS05715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DFS30_RS05730	COG1902	pentaerythritol trinitrate reductase activity
DFS30_RS05730	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFS30_RS05740	COG3119	arylsulfatase activity
DFS30_RS05745	COG0514	ATP-dependent DNA helicase (RecQ)
DFS30_RS05765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DFS30_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DFS30_RS05825	COG1858	cytochrome C peroxidase
DFS30_RS05830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DFS30_RS05835	COG0590	tRNA wobble adenosine to inosine editing
DFS30_RS05840	COG1940	carbohydrate kinase activity
DFS30_RS05845	COG2217	Heavy metal translocating P-type atpase
DFS30_RS05850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DFS30_RS05880	COG1363	Peptidase, m42
DFS30_RS05885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DFS30_RS05895	COG0006	proline dipeptidase activity
DFS30_RS05900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DFS30_RS05925	COG5002	protein histidine kinase activity
DFS30_RS05930	COG0745	RESPONSE REGULATOR receiver
DFS30_RS05935	COG0129	dihydroxy-acid dehydratase activity
DFS30_RS05960	COG1368	sulfuric ester hydrolase activity
DFS30_RS05990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DFS30_RS05995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DFS30_RS06015	COG0534	Mate efflux family protein
DFS30_RS06020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DFS30_RS06035	COG1876	peptidase activity
DFS30_RS06175	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DFS30_RS06180	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DFS30_RS06185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DFS30_RS06190	COG2205	protein histidine kinase activity
DFS30_RS06195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DFS30_RS06205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFS30_RS06220	COG0667	Aldo Keto reductase
DFS30_RS06225	COG0789	Transcriptional regulator
DFS30_RS06270	COG0714	Associated with various cellular activities
DFS30_RS06275	COG2311	Membrane
DFS30_RS06295	COG1090	epimerase
DFS30_RS06305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DFS30_RS06310	COG1119	ATPase activity
DFS30_RS06315	COG2186	Transcriptional regulator
DFS30_RS06345	COG0148	phosphopyruvate hydratase activity
DFS30_RS06350	COG0436	Aminotransferase
DFS30_RS06355	COG1477	protein flavinylation
DFS30_RS06370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DFS30_RS06380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DFS30_RS06400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DFS30_RS06410	COG1199	ATP-dependent helicase activity
DFS30_RS06415	COG1122	ATPase activity
DFS30_RS06440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DFS30_RS06445	COG0598	Magnesium transport protein CorA
DFS30_RS06450	COG0359	binds to the 23S rRNA
DFS30_RS06455	COG0138	bifunctional purine biosynthesis protein purh
DFS30_RS06460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DFS30_RS06465	COG0736	holo-[acyl-carrier-protein] synthase activity
DFS30_RS06475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DFS30_RS06480	COG3409	Peptidoglycan-binding domain 1 protein
DFS30_RS06480	COG5632	N-Acetylmuramoyl-L-alanine amidase
DFS30_RS06485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFS30_RS06495	COG0437	4 iron, 4 sulfur cluster binding
DFS30_RS06515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFS30_RS06565	COG0284	orotidine-5'-phosphate decarboxylase activity
DFS30_RS06585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DFS30_RS06590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DFS30_RS06610	COG2003	Belongs to the UPF0758 family
DFS30_RS06615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DFS30_RS06615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DFS30_RS06620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DFS30_RS06625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DFS30_RS06630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DFS30_RS06635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DFS30_RS06640	COG0322	excinuclease ABC activity
DFS30_RS06645	COG0811	peptide transport
DFS30_RS06650	COG0848	biopolymer transport protein
DFS30_RS06660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DFS30_RS06665	COG0483	inositol monophosphate 1-phosphatase activity
DFS30_RS06670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DFS30_RS06680	COG1482	cell wall glycoprotein biosynthetic process
DFS30_RS06690	COG1757	Na H antiporter
DFS30_RS06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFS30_RS06700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DFS30_RS06705	COG0505	Belongs to the CarA family
DFS30_RS06710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DFS30_RS06720	COG0070	glutamate synthase
DFS30_RS06720	COG0069	glutamate synthase activity
DFS30_RS06720	COG0067	glutamate synthase
DFS30_RS06725	COG0706	membrane insertase activity
DFS30_RS06730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DFS30_RS06740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DFS30_RS06750	COG2755	lipolytic protein G-D-S-L family
DFS30_RS06750	COG0657	acetylesterase activity
DFS30_RS06760	COG0676	glucose-6-phosphate 1-epimerase activity
DFS30_RS06765	COG0259	pyridoxamine-phosphate oxidase activity
DFS30_RS06780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DFS30_RS06795	COG1760	l-serine dehydratase
DFS30_RS06800	COG0492	ferredoxin-NADP+ reductase activity
DFS30_RS06800	COG3118	belongs to the thioredoxin family
DFS30_RS06850	COG1408	metallophosphoesterase
DFS30_RS06860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DFS30_RS06865	COG0545	Peptidyl-prolyl cis-trans isomerase
DFS30_RS06880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DFS30_RS06890	COG0826	peptidase U32
DFS30_RS06895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DFS30_RS06915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DFS30_RS06935	COG0529	Catalyzes the synthesis of activated sulfate
DFS30_RS06935	COG2895	sulfate adenylyltransferase (ATP) activity
DFS30_RS06940	COG0175	sulfate reduction
DFS30_RS06945	COG0175	sulfate reduction
DFS30_RS06965	COG0581	inorganic phosphate transmembrane transporter activity
DFS30_RS06970	COG0573	inorganic phosphate transmembrane transporter activity
DFS30_RS06980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DFS30_RS06990	COG2017	converts alpha-aldose to the beta-anomer
DFS30_RS07005	COG0612	Peptidase, M16
DFS30_RS07045	COG0233	cytoplasmic translational termination
DFS30_RS07050	COG0528	UMP kinase activity
DFS30_RS07055	COG0668	transmembrane transport
DFS30_RS07060	COG0450	alkyl hydroperoxide reductase
DFS30_RS07065	COG0733	neurotransmitter:sodium symporter activity
DFS30_RS07080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DFS30_RS07090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DFS30_RS07095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DFS30_RS07100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DFS30_RS07120	COG0842	Transport permease protein
DFS30_RS07125	COG0842	Transport permease protein
DFS30_RS07130	COG1131	(ABC) transporter
DFS30_RS07140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFS30_RS07145	COG1183	phosphatidylcholine synthase activity
DFS30_RS07155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DFS30_RS07165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DFS30_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
DFS30_RS07190	COG0156	8-amino-7-oxononanoate synthase activity
DFS30_RS07210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DFS30_RS07215	COG0124	histidyl-tRNA synthetase
DFS30_RS07220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DFS30_RS07225	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DFS30_RS07230	COG0298	carbon dioxide binding
DFS30_RS07255	COG0438	transferase activity, transferring glycosyl groups
DFS30_RS07260	COG0443	Heat shock 70 kDa protein
DFS30_RS07265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DFS30_RS07270	COG0459	protein refolding
DFS30_RS07320	COG0632	four-way junction helicase activity
DFS30_RS07330	COG0126	phosphoglycerate kinase activity
DFS30_RS07340	COG1082	Xylose isomerase domain protein TIM barrel
DFS30_RS07350	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DFS30_RS07360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DFS30_RS07370	COG2271	Major facilitator Superfamily
DFS30_RS07385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DFS30_RS07395	COG0037	tRNA processing
DFS30_RS07400	COG0254	rRNA binding
DFS30_RS07440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DFS30_RS07445	COG0039	L-malate dehydrogenase activity
DFS30_RS07465	COG0778	Nitroreductase
DFS30_RS07470	COG0564	pseudouridine synthase activity
DFS30_RS07495	COG1126	abc transporter atp-binding protein
DFS30_RS07500	COG0765	amino acid transport
DFS30_RS07510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DFS30_RS07515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DFS30_RS07565	COG1872	DUF167
DFS30_RS07570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DFS30_RS07575	COG0484	heat shock protein binding
DFS30_RS07580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DFS30_RS07590	COG5434	Belongs to the glycosyl hydrolase 28 family
DFS30_RS07605	COG0277	FAD linked oxidase domain protein
DFS30_RS07630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DFS30_RS07635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DFS30_RS07645	COG0131	Imidazoleglycerol-phosphate dehydratase
DFS30_RS07650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DFS30_RS07655	COG0360	Binds together with S18 to 16S ribosomal RNA
DFS30_RS07660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DFS30_RS07675	COG1686	Belongs to the peptidase S11 family
DFS30_RS07680	COG0205	6-phosphofructokinase activity
DFS30_RS07690	COG0428	transporter
DFS30_RS07695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DFS30_RS07715	COG3977	Valine--pyruvate aminotransferase
DFS30_RS07720	COG1561	YicC-like family, N-terminal region
DFS30_RS07730	COG0471	metal ion transport
DFS30_RS07730	COG3273	potassium ion transport
DFS30_RS07735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DFS30_RS07750	COG1575	Belongs to the MenA family. Type 1 subfamily
DFS30_RS07785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DFS30_RS07785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DFS30_RS07805	COG0202	RNA polymerase activity
DFS30_RS07810	COG0203	ribosomal protein L17
DFS30_RS07815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DFS30_RS07825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DFS30_RS07840	COG2885	chlorophyll binding
DFS30_RS07895	COG0667	Aldo Keto reductase
DFS30_RS07900	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DFS30_RS07915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFS30_RS07920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DFS30_RS07925	COG0134	indole-3-glycerol-phosphate synthase activity
DFS30_RS07930	COG0135	phosphoribosylanthranilate isomerase activity
DFS30_RS07935	COG0133	tryptophan synthase activity
DFS30_RS07940	COG0159	tryptophan synthase activity
DFS30_RS07955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DFS30_RS07960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DFS30_RS07970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DFS30_RS08005	COG0561	phosphatase activity
DFS30_RS08010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFS30_RS08015	COG2223	nitrite transmembrane transporter activity
DFS30_RS08030	COG0556	nucleotide-excision repair
DFS30_RS08035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DFS30_RS08040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DFS30_RS08060	COG1074	ATP-dependent DNA helicase activity
DFS30_RS08070	COG0697	spore germination
DFS30_RS08075	COG2373	Large extracellular alpha-helical protein
DFS30_RS08080	COG1979	alcohol dehydrogenase
DFS30_RS08090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DFS30_RS08115	COG0372	Belongs to the citrate synthase family
DFS30_RS08135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DFS30_RS08145	COG1187	pseudouridine synthase activity
DFS30_RS08155	COG0105	UTP biosynthetic process
DFS30_RS08160	COG1215	transferase activity, transferring glycosyl groups
DFS30_RS08165	COG0463	Glycosyl transferase, family 2
DFS30_RS08175	COG1459	type II secretion system
DFS30_RS08180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DFS30_RS08185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DFS30_RS08190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DFS30_RS08205	COG0728	peptidoglycan biosynthetic process
DFS30_RS08210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFS30_RS08210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DFS30_RS08220	COG1649	PFAM Uncharacterised BCR, COG1649
DFS30_RS08225	COG1691	(AIR) carboxylase
DFS30_RS08230	COG1606	tRNA processing
DFS30_RS08235	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DFS30_RS08240	COG0142	geranyltranstransferase activity
DFS30_RS08255	COG2151	metal-sulfur cluster biosynthetic enzyme
DFS30_RS08275	COG1007	ATP synthesis coupled electron transport
DFS30_RS08280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFS30_RS08290	COG0713	ATP synthesis coupled electron transport
DFS30_RS08295	COG0839	Belongs to the complex I subunit 6 family
DFS30_RS08305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DFS30_RS08310	COG1034	ATP synthesis coupled electron transport
DFS30_RS08315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DFS30_RS08320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DFS30_RS08325	COG0649	NAD binding
DFS30_RS08335	COG0726	polysaccharide deacetylase
DFS30_RS08345	COG0307	riboflavin synthase, alpha
DFS30_RS08350	COG2264	protein methyltransferase activity
DFS30_RS08355	COG3210	domain, Protein
DFS30_RS08365	COG1640	4-alpha-glucanotransferase
DFS30_RS08375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFS30_RS08380	COG1030	water channel activity
DFS30_RS08385	COG0358	DNA primase activity
DFS30_RS08390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DFS30_RS08395	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DFS30_RS08410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DFS30_RS08415	COG0793	Belongs to the peptidase S41A family
DFS30_RS08425	COG1643	Atp-dependent helicase
DFS30_RS08450	COG1450	Type ii and iii secretion system protein
DFS30_RS08465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DFS30_RS08485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DFS30_RS08490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DFS30_RS08500	COG0268	Binds directly to 16S ribosomal RNA
DFS30_RS08505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DFS30_RS08510	COG0028	Belongs to the TPP enzyme family
DFS30_RS08520	COG0688	phosphatidylethanolamine metabolic process
DFS30_RS08525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DFS30_RS08530	COG0495	leucyl-tRNA aminoacylation
DFS30_RS08535	COG3119	arylsulfatase activity
DFS30_RS08550	COG1166	arginine decarboxylase activity
DFS30_RS08560	COG3250	beta-galactosidase activity
DFS30_RS08565	COG3250	beta-galactosidase activity
DFS30_RS08570	COG3250	beta-galactosidase activity
DFS30_RS08575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFS30_RS08580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS08590	COG0205	6-phosphofructokinase activity
DFS30_RS08610	COG0535	radical SAM domain protein
DFS30_RS08650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DFS30_RS08655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DFS30_RS08660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DFS30_RS08670	COG4771	TonB-dependent receptor
DFS30_RS08690	COG0402	S-adenosylhomocysteine deaminase activity
DFS30_RS08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFS30_RS08715	COG1294	oxidase, subunit
DFS30_RS08720	COG1271	oxidase subunit
DFS30_RS08730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DFS30_RS08750	COG1846	Transcriptional regulator
DFS30_RS08780	COG2949	membrane
DFS30_RS08805	COG0514	ATP-dependent DNA helicase (RecQ)
DFS30_RS08820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DFS30_RS08825	COG0045	succinate-CoA ligase (ADP-forming) activity
DFS30_RS08830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DFS30_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFS30_RS08900	COG2205	protein histidine kinase activity
DFS30_RS08915	COG0113	porphobilinogen synthase activity
DFS30_RS08925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFS30_RS08945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DFS30_RS08970	COG4106	trans-aconitate 2-methyltransferase activity
DFS30_RS08985	COG3475	LICD family
DFS30_RS08990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFS30_RS09000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFS30_RS09005	COG3475	LICD family
DFS30_RS09010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DFS30_RS09020	COG2166	iron-sulfur cluster assembly
DFS30_RS09025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DFS30_RS09035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFS30_RS09040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DFS30_RS09045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DFS30_RS09050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFS30_RS09055	COG1131	(ABC) transporter
DFS30_RS09070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DFS30_RS09085	COG1215	transferase activity, transferring glycosyl groups
DFS30_RS09100	COG1401	restriction endodeoxyribonuclease activity
DFS30_RS09100	COG1401	restriction endodeoxyribonuclease activity
DFS30_RS09115	COG1522	sequence-specific DNA binding
DFS30_RS09120	COG0436	Aminotransferase
DFS30_RS09135	COG0423	glycine-tRNA ligase activity
DFS30_RS09140	COG0656	L-ascorbic acid biosynthetic process
DFS30_RS09155	COG2304	oxidoreductase activity
DFS30_RS09170	COG0714	Associated with various cellular activities
DFS30_RS09175	COG0154	amidase activity
DFS30_RS09180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFS30_RS09220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DFS30_RS09255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DFS30_RS09265	COG0656	L-ascorbic acid biosynthetic process
DFS30_RS09275	COG0667	Aldo Keto reductase
DFS30_RS09280	COG1408	metallophosphoesterase
DFS30_RS09300	COG2249	NAD(P)H dehydrogenase (quinone) activity
DFS30_RS09305	COG0789	Transcriptional regulator
DFS30_RS09320	COG0534	Mate efflux family protein
DFS30_RS09340	COG1091	dTDP-4-dehydrorhamnose reductase activity
DFS30_RS09355	COG1837	Belongs to the UPF0109 family
DFS30_RS09360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DFS30_RS09365	COG0363	glucosamine-6-phosphate deaminase activity
DFS30_RS09385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DFS30_RS09410	COG1070	Carbohydrate kinase
DFS30_RS09425	COG0738	Major facilitator superfamily
DFS30_RS09440	COG1595	DNA-templated transcription, initiation
DFS30_RS09460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DFS30_RS09480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DFS30_RS09485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DFS30_RS09490	COG0697	spore germination
DFS30_RS09495	COG3586	endonuclease activity
DFS30_RS09505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DFS30_RS09510	COG4608	Belongs to the ABC transporter superfamily
DFS30_RS09515	COG0444	Belongs to the ABC transporter superfamily
DFS30_RS09520	COG4166	transmembrane transport
DFS30_RS09525	COG4239	(ABC) transporter, permease
DFS30_RS09530	COG0601	transmembrane transport
DFS30_RS09545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DFS30_RS09550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DFS30_RS09555	COG3738	Protein conserved in bacteria
DFS30_RS09560	COG0151	Belongs to the GarS family
DFS30_RS09575	COG0811	peptide transport
DFS30_RS09585	COG0242	peptide deformylase activity
DFS30_RS09620	COG2010	Cytochrome c
DFS30_RS09630	COG3258	Cytochrome c
DFS30_RS09645	COG3274	enterobacterial common antigen metabolic process
DFS30_RS09650	COG0538	isocitrate dehydrogenase activity
DFS30_RS09665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFS30_RS09670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFS30_RS09675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFS30_RS09685	COG0668	transmembrane transport
DFS30_RS09690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DFS30_RS09690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DFS30_RS09695	COG0805	protein transport
DFS30_RS09700	COG1968	undecaprenyl-diphosphatase activity
DFS30_RS09720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DFS30_RS09730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DFS30_RS09740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DFS30_RS09750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DFS30_RS09760	COG1408	metallophosphoesterase
DFS30_RS09785	COG4974	Belongs to the 'phage' integrase family
DFS30_RS09805	COG1454	alcohol dehydrogenase
DFS30_RS09810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DFS30_RS09820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DFS30_RS09820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DFS30_RS09825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DFS30_RS09865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DFS30_RS09875	COG4607	ABC-type enterochelin transport system periplasmic component
DFS30_RS09880	COG4604	ABC transporter, ATP-binding protein
DFS30_RS09885	COG4605	iron ion homeostasis
DFS30_RS09890	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DFS30_RS09925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFS30_RS09925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFS30_RS09940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DFS30_RS09945	COG2195	Cleaves the N-terminal amino acid of tripeptides
DFS30_RS09965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFS30_RS09980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFS30_RS10005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DFS30_RS10040	COG0646	methionine synthase
DFS30_RS10040	COG1410	methionine synthase
DFS30_RS10045	COG2966	Psort location CytoplasmicMembrane, score
DFS30_RS10050	COG3610	response to peptide
DFS30_RS10065	COG0460	homoserine dehydrogenase
DFS30_RS10070	COG0527	aspartate kinase activity
DFS30_RS10080	COG5522	Integral membrane protein (intg_mem_TP0381)
DFS30_RS10090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DFS30_RS10095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DFS30_RS10105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DFS30_RS10110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFS30_RS10110	COG0574	Belongs to the PEP-utilizing enzyme family
DFS30_RS10125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DFS30_RS10135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFS30_RS10135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFS30_RS10170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DFS30_RS10175	COG2818	Glycosylase
DFS30_RS10195	COG3033	Beta-eliminating lyase
DFS30_RS10210	COG0072	phenylalanine-tRNA ligase activity
DFS30_RS10210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFS30_RS10230	COG0326	Molecular chaperone. Has ATPase activity
DFS30_RS10255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DFS30_RS10260	COG1959	2 iron, 2 sulfur cluster binding
DFS30_RS10275	COG0352	thiamine-phosphate diphosphorylase activity
DFS30_RS10280	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DFS30_RS10295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS10305	COG1703	isobutyryl-CoA mutase activity
DFS30_RS10325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DFS30_RS10335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFS30_RS10340	COG0418	dihydroorotase activity
DFS30_RS10355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DFS30_RS10375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DFS30_RS10390	COG0534	Mate efflux family protein
DFS30_RS10395	COG0489	protein tyrosine kinase activity
DFS30_RS10405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFS30_RS10410	COG0339	signal peptide processing
DFS30_RS10420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DFS30_RS10430	COG1538	Outer membrane efflux protein
DFS30_RS10445	COG4112	unkown
DFS30_RS10460	COG0038	chloride channel
DFS30_RS10470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DFS30_RS10475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DFS30_RS10480	COG0586	Pfam SNARE associated Golgi protein
DFS30_RS10745	COG1518	maintenance of DNA repeat elements
DFS30_RS10780	COG1012	belongs to the aldehyde dehydrogenase family
DFS30_RS10795	COG0753	catalase activity
DFS30_RS10805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DFS30_RS10810	COG1592	Rubrerythrin
DFS30_RS10815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DFS30_RS10850	COG0489	protein tyrosine kinase activity
DFS30_RS10860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DFS30_RS10870	COG2244	polysaccharide biosynthetic process
DFS30_RS10875	COG1215	transferase activity, transferring glycosyl groups
DFS30_RS10885	COG1216	Glycosyl transferase, family 2
DFS30_RS10900	COG0438	transferase activity, transferring glycosyl groups
DFS30_RS10930	COG1216	Glycosyl transferase, family 2
DFS30_RS10950	COG2755	lipolytic protein G-D-S-L family
DFS30_RS10950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DFS30_RS10970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DFS30_RS10975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFS30_RS10980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DFS30_RS10985	COG0281	malic enzyme
DFS30_RS10985	COG0280	phosphate acetyltransferase
DFS30_RS11000	COG1472	Belongs to the glycosyl hydrolase 3 family
DFS30_RS11005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DFS30_RS11020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DFS30_RS11060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DFS30_RS11065	COG1063	alcohol dehydrogenase
DFS30_RS11080	COG0714	Associated with various cellular activities
DFS30_RS11090	COG0193	aminoacyl-tRNA hydrolase activity
DFS30_RS11095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DFS30_RS11110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DFS30_RS11130	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DFS30_RS11145	COG0375	protein maturation
DFS30_RS11170	COG0778	Nitroreductase
DFS30_RS11175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFS30_RS11195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DFS30_RS11205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DFS30_RS11205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DFS30_RS11225	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DFS30_RS11245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DFS30_RS11250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DFS30_RS11255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DFS30_RS11305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFS30_RS11310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFS30_RS11325	COG0318	PFAM AMP-dependent synthetase and ligase
DFS30_RS11350	COG0339	signal peptide processing
DFS30_RS11360	COG0018	arginyl-trna synthetase
DFS30_RS11400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DFS30_RS11405	COG0653	protein targeting
DFS30_RS11420	COG0494	nUDIX hydrolase
DFS30_RS11425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DFS30_RS11510	COG1979	alcohol dehydrogenase
DFS30_RS11515	COG1979	alcohol dehydrogenase