locus-tag	class	description
A4V05_RS00055	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4V05_RS00055	COG3409	Peptidoglycan-binding domain 1 protein
A4V05_RS00060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4V05_RS00085	COG1690	Belongs to the RtcB family
A4V05_RS00095	COG2814	Major facilitator Superfamily
A4V05_RS00105	COG2096	Adenosyltransferase
A4V05_RS00115	COG0557	exoribonuclease II activity
A4V05_RS00120	COG0826	peptidase U32
A4V05_RS00125	COG0285	dihydrofolate synthase activity
A4V05_RS00140	COG0673	inositol 2-dehydrogenase activity
A4V05_RS00145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V05_RS00150	COG0737	Belongs to the 5'-nucleotidase family
A4V05_RS00160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V05_RS00165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4V05_RS00180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V05_RS00185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4V05_RS00190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V05_RS00195	COG0200	Binds to the 23S rRNA
A4V05_RS00200	COG0201	protein transport
A4V05_RS00205	COG0563	adenylate kinase activity
A4V05_RS00210	COG0024	Methionine aminopeptidase
A4V05_RS00225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V05_RS00230	COG1442	glycosyl transferase family 8
A4V05_RS00240	COG1216	Glycosyl transferase, family 2
A4V05_RS00250	COG1216	Glycosyl transferase, family 2
A4V05_RS00265	COG1216	Glycosyl transferase, family 2
A4V05_RS00270	COG0693	protein deglycase activity
A4V05_RS00275	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4V05_RS00280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V05_RS00285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V05_RS00295	COG1966	Carbon starvation protein
A4V05_RS00310	COG3119	arylsulfatase activity
A4V05_RS00315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V05_RS00320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V05_RS00325	COG0195	Participates in both transcription termination and antitermination
A4V05_RS00330	COG0708	Exodeoxyribonuclease III
A4V05_RS00335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V05_RS00340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4V05_RS00345	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V05_RS00360	COG0842	Transport permease protein
A4V05_RS00360	COG1131	(ABC) transporter
A4V05_RS00360	COG1716	ATPase activity
A4V05_RS00380	COG0724	RNA recognition motif
A4V05_RS00385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V05_RS00395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V05_RS00415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4V05_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V05_RS00430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V05_RS00445	COG1490	D-aminoacyl-tRNA deacylase activity
A4V05_RS00475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4V05_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
A4V05_RS00540	COG0488	(ABC) transporter
A4V05_RS00550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4V05_RS00560	COG1253	flavin adenine dinucleotide binding
A4V05_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
A4V05_RS00575	COG1073	alpha beta
A4V05_RS00585	COG0667	Aldo Keto reductase
A4V05_RS00640	COG2267	carboxylic ester hydrolase activity
A4V05_RS00645	COG2095	MarC family integral membrane protein
A4V05_RS00685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V05_RS00690	COG0488	(ABC) transporter
A4V05_RS00700	COG0697	spore germination
A4V05_RS00710	COG0215	cysteine-tRNA ligase activity
A4V05_RS00720	COG3119	arylsulfatase activity
A4V05_RS00735	COG0481	GTPase activity
A4V05_RS00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V05_RS00760	COG0085	RNA polymerase activity
A4V05_RS00765	COG0222	ribosome binding
A4V05_RS00770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4V05_RS00775	COG0081	regulation of translation
A4V05_RS00780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4V05_RS00785	COG0250	Participates in transcription elongation, termination and antitermination
A4V05_RS00800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V05_RS00810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V05_RS00820	COG0740	serine-type endopeptidase activity
A4V05_RS00825	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V05_RS00840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V05_RS00860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V05_RS00905	COG2226	methyltransferase
A4V05_RS00910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V05_RS00915	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4V05_RS00935	COG1902	pentaerythritol trinitrate reductase activity
A4V05_RS00935	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V05_RS00945	COG3119	arylsulfatase activity
A4V05_RS00950	COG0514	ATP-dependent DNA helicase (RecQ)
A4V05_RS00970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4V05_RS00975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V05_RS01025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V05_RS01040	COG1858	cytochrome C peroxidase
A4V05_RS01045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4V05_RS01050	COG0590	tRNA wobble adenosine to inosine editing
A4V05_RS01055	COG1940	carbohydrate kinase activity
A4V05_RS01060	COG2217	Heavy metal translocating P-type atpase
A4V05_RS01065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4V05_RS01070	COG0237	dephospho-CoA kinase activity
A4V05_RS01100	COG1363	Peptidase, m42
A4V05_RS01105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4V05_RS01115	COG0006	proline dipeptidase activity
A4V05_RS01120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V05_RS01135	COG5002	protein histidine kinase activity
A4V05_RS01140	COG0745	RESPONSE REGULATOR receiver
A4V05_RS01145	COG0129	dihydroxy-acid dehydratase activity
A4V05_RS01170	COG1368	sulfuric ester hydrolase activity
A4V05_RS01205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V05_RS01210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V05_RS01230	COG0534	Mate efflux family protein
A4V05_RS01235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V05_RS01250	COG1876	peptidase activity
A4V05_RS01320	COG3209	COG3209 Rhs family protein
A4V05_RS01365	COG3209	COG3209 Rhs family protein
A4V05_RS01395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4V05_RS01400	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4V05_RS01405	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4V05_RS01410	COG2205	protein histidine kinase activity
A4V05_RS01420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4V05_RS01430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V05_RS01445	COG0667	Aldo Keto reductase
A4V05_RS01450	COG0789	Transcriptional regulator
A4V05_RS01500	COG0714	Associated with various cellular activities
A4V05_RS01530	COG1090	epimerase
A4V05_RS01545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V05_RS01550	COG1119	ATPase activity
A4V05_RS01555	COG2186	Transcriptional regulator
A4V05_RS01580	COG0148	phosphopyruvate hydratase activity
A4V05_RS01585	COG0436	Aminotransferase
A4V05_RS01590	COG1477	protein flavinylation
A4V05_RS01605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V05_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4V05_RS01640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V05_RS01650	COG1199	ATP-dependent helicase activity
A4V05_RS01655	COG1122	ATPase activity
A4V05_RS01680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V05_RS01685	COG0598	Magnesium transport protein CorA
A4V05_RS01690	COG0359	binds to the 23S rRNA
A4V05_RS01695	COG0138	bifunctional purine biosynthesis protein purh
A4V05_RS01700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4V05_RS01705	COG0736	holo-[acyl-carrier-protein] synthase activity
A4V05_RS01715	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4V05_RS01720	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4V05_RS01720	COG3409	Peptidoglycan-binding domain 1 protein
A4V05_RS01725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V05_RS01735	COG0437	4 iron, 4 sulfur cluster binding
A4V05_RS01755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V05_RS01810	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V05_RS01830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4V05_RS01835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V05_RS01855	COG2003	Belongs to the UPF0758 family
A4V05_RS01860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V05_RS01860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V05_RS01865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V05_RS01870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4V05_RS01875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4V05_RS01880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V05_RS01885	COG0322	excinuclease ABC activity
A4V05_RS01890	COG0811	peptide transport
A4V05_RS01895	COG0848	biopolymer transport protein
A4V05_RS01905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4V05_RS01910	COG0483	inositol monophosphate 1-phosphatase activity
A4V05_RS01915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V05_RS01925	COG1482	cell wall glycoprotein biosynthetic process
A4V05_RS01935	COG1757	Na H antiporter
A4V05_RS01940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V05_RS01945	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4V05_RS01950	COG0505	Belongs to the CarA family
A4V05_RS01955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V05_RS01965	COG0067	glutamate synthase
A4V05_RS01965	COG0069	glutamate synthase activity
A4V05_RS01965	COG0070	glutamate synthase
A4V05_RS01975	COG0706	membrane insertase activity
A4V05_RS01980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4V05_RS01985	COG0594	ribonuclease P activity
A4V05_RS01990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V05_RS02000	COG2755	lipolytic protein G-D-S-L family
A4V05_RS02000	COG0657	acetylesterase activity
A4V05_RS02015	COG0259	pyridoxamine-phosphate oxidase activity
A4V05_RS02030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4V05_RS02050	COG1760	l-serine dehydratase
A4V05_RS02055	COG3118	belongs to the thioredoxin family
A4V05_RS02055	COG0492	ferredoxin-NADP+ reductase activity
A4V05_RS02115	COG1408	metallophosphoesterase
A4V05_RS02125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V05_RS02130	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V05_RS02150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V05_RS02160	COG0826	peptidase U32
A4V05_RS02165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4V05_RS02195	COG0581	inorganic phosphate transmembrane transporter activity
A4V05_RS02200	COG0573	inorganic phosphate transmembrane transporter activity
A4V05_RS02210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V05_RS02220	COG2017	converts alpha-aldose to the beta-anomer
A4V05_RS02235	COG0612	Peptidase, M16
A4V05_RS02245	COG0110	maltose O-acetyltransferase activity
A4V05_RS02295	COG0233	cytoplasmic translational termination
A4V05_RS02300	COG0528	UMP kinase activity
A4V05_RS02305	COG0668	transmembrane transport
A4V05_RS02310	COG0450	alkyl hydroperoxide reductase
A4V05_RS02315	COG0733	neurotransmitter:sodium symporter activity
A4V05_RS02330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V05_RS02340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V05_RS02345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4V05_RS02350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V05_RS02375	COG0842	Transport permease protein
A4V05_RS02380	COG0842	Transport permease protein
A4V05_RS02385	COG1131	(ABC) transporter
A4V05_RS02395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V05_RS02400	COG1183	phosphatidylcholine synthase activity
A4V05_RS02410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V05_RS02420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V05_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
A4V05_RS02450	COG0156	8-amino-7-oxononanoate synthase activity
A4V05_RS02475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V05_RS02480	COG0124	histidyl-tRNA synthetase
A4V05_RS02485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4V05_RS02490	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4V05_RS02495	COG0298	carbon dioxide binding
A4V05_RS02520	COG0438	transferase activity, transferring glycosyl groups
A4V05_RS02525	COG0443	Heat shock 70 kDa protein
A4V05_RS02530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V05_RS02535	COG0459	protein refolding
A4V05_RS02585	COG0632	four-way junction helicase activity
A4V05_RS02595	COG0126	phosphoglycerate kinase activity
A4V05_RS02610	COG1082	Xylose isomerase domain protein TIM barrel
A4V05_RS02615	COG3064	Membrane
A4V05_RS02615	COG0515	serine threonine protein kinase
A4V05_RS02615	COG4991	sh3 domain protein
A4V05_RS02620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V05_RS02630	COG2271	Major facilitator Superfamily
A4V05_RS02645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V05_RS02655	COG0037	tRNA processing
A4V05_RS02660	COG0254	rRNA binding
A4V05_RS02695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4V05_RS02700	COG0039	L-malate dehydrogenase activity
A4V05_RS02725	COG0778	Nitroreductase
A4V05_RS02730	COG0564	pseudouridine synthase activity
A4V05_RS02760	COG1126	abc transporter atp-binding protein
A4V05_RS02765	COG0765	amino acid transport
A4V05_RS02775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V05_RS02780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4V05_RS02805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V05_RS02830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4V05_RS02835	COG1872	DUF167
A4V05_RS02840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V05_RS02845	COG0484	heat shock protein binding
A4V05_RS02850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4V05_RS02860	COG5434	Belongs to the glycosyl hydrolase 28 family
A4V05_RS02875	COG0277	FAD linked oxidase domain protein
A4V05_RS02900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V05_RS02905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4V05_RS02915	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V05_RS02920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V05_RS02925	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V05_RS02930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4V05_RS02945	COG1686	Belongs to the peptidase S11 family
A4V05_RS02950	COG0205	6-phosphofructokinase activity
A4V05_RS02960	COG0428	transporter
A4V05_RS02965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V05_RS02980	COG3977	Valine--pyruvate aminotransferase
A4V05_RS02985	COG1561	YicC-like family, N-terminal region
A4V05_RS02995	COG3273	potassium ion transport
A4V05_RS02995	COG0471	metal ion transport
A4V05_RS03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V05_RS03015	COG1575	Belongs to the MenA family. Type 1 subfamily
A4V05_RS03020	COG0710	3-dehydroquinate dehydratase activity
A4V05_RS03055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V05_RS03055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V05_RS03075	COG0202	RNA polymerase activity
A4V05_RS03080	COG0203	ribosomal protein L17
A4V05_RS03085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V05_RS03095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V05_RS03110	COG2885	chlorophyll binding
A4V05_RS03150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V05_RS03190	COG0667	Aldo Keto reductase
A4V05_RS03195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A4V05_RS03215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4V05_RS03220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4V05_RS03225	COG0134	indole-3-glycerol-phosphate synthase activity
A4V05_RS03230	COG0135	phosphoribosylanthranilate isomerase activity
A4V05_RS03240	COG0159	tryptophan synthase activity
A4V05_RS03260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4V05_RS03265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V05_RS03275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V05_RS03310	COG0561	phosphatase activity
A4V05_RS03315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V05_RS03320	COG2223	nitrite transmembrane transporter activity
A4V05_RS03340	COG0556	nucleotide-excision repair
A4V05_RS03350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4V05_RS03355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4V05_RS03360	COG0750	zinc metalloprotease
A4V05_RS03375	COG1074	ATP-dependent DNA helicase activity
A4V05_RS03390	COG0697	spore germination
A4V05_RS03395	COG2373	Large extracellular alpha-helical protein
A4V05_RS03400	COG1979	alcohol dehydrogenase
A4V05_RS03410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4V05_RS03435	COG0372	Belongs to the citrate synthase family
A4V05_RS03455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V05_RS03465	COG1187	pseudouridine synthase activity
A4V05_RS03475	COG0105	UTP biosynthetic process
A4V05_RS03480	COG1215	transferase activity, transferring glycosyl groups
A4V05_RS03485	COG0463	Glycosyl transferase, family 2
A4V05_RS03495	COG1459	type II secretion system
A4V05_RS03500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4V05_RS03505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4V05_RS03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V05_RS03525	COG0728	peptidoglycan biosynthetic process
A4V05_RS03530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V05_RS03530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4V05_RS03545	COG1649	PFAM Uncharacterised BCR, COG1649
A4V05_RS03550	COG1691	(AIR) carboxylase
A4V05_RS03555	COG0037	tRNA processing
A4V05_RS03560	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A4V05_RS03565	COG0142	geranyltranstransferase activity
A4V05_RS03580	COG2151	metal-sulfur cluster biosynthetic enzyme
A4V05_RS03595	COG1007	ATP synthesis coupled electron transport
A4V05_RS03600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V05_RS03610	COG0713	ATP synthesis coupled electron transport
A4V05_RS03615	COG0839	Belongs to the complex I subunit 6 family
A4V05_RS03625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4V05_RS03630	COG1034	ATP synthesis coupled electron transport
A4V05_RS03635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4V05_RS03640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A4V05_RS03645	COG0649	NAD binding
A4V05_RS03655	COG0726	polysaccharide deacetylase
A4V05_RS03665	COG0307	riboflavin synthase, alpha
A4V05_RS03675	COG2264	protein methyltransferase activity
A4V05_RS03685	COG3210	domain, Protein
A4V05_RS03690	COG1640	4-alpha-glucanotransferase
A4V05_RS03705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V05_RS03710	COG1030	water channel activity
A4V05_RS03715	COG0358	DNA primase activity
A4V05_RS03720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V05_RS03725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4V05_RS03740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4V05_RS03745	COG0793	Belongs to the peptidase S41A family
A4V05_RS03760	COG1643	Atp-dependent helicase
A4V05_RS03785	COG1450	Type ii and iii secretion system protein
A4V05_RS03800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V05_RS03820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V05_RS03825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V05_RS03835	COG0268	Binds directly to 16S ribosomal RNA
A4V05_RS03840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V05_RS03845	COG0028	Belongs to the TPP enzyme family
A4V05_RS03850	COG0688	phosphatidylethanolamine metabolic process
A4V05_RS03855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V05_RS03860	COG0495	leucyl-tRNA aminoacylation
A4V05_RS03865	COG3119	arylsulfatase activity
A4V05_RS03880	COG1166	arginine decarboxylase activity
A4V05_RS03890	COG3250	beta-galactosidase activity
A4V05_RS03895	COG3250	beta-galactosidase activity
A4V05_RS03900	COG3250	beta-galactosidase activity
A4V05_RS03905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V05_RS03910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS03925	COG0205	6-phosphofructokinase activity
A4V05_RS03960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4V05_RS03965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A4V05_RS03970	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4V05_RS03985	COG4771	TonB-dependent receptor
A4V05_RS04010	COG0402	S-adenosylhomocysteine deaminase activity
A4V05_RS04015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V05_RS04040	COG1294	oxidase, subunit
A4V05_RS04045	COG1271	oxidase subunit
A4V05_RS04055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V05_RS04075	COG1846	Transcriptional regulator
A4V05_RS04200	COG0305	Participates in initiation and elongation during chromosome replication
A4V05_RS04325	COG2949	membrane
A4V05_RS04355	COG0514	ATP-dependent DNA helicase (RecQ)
A4V05_RS04370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4V05_RS04375	COG0045	succinate-CoA ligase (ADP-forming) activity
A4V05_RS04380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V05_RS04445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V05_RS04450	COG2205	protein histidine kinase activity
A4V05_RS04465	COG0113	porphobilinogen synthase activity
A4V05_RS04480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V05_RS04500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V05_RS04525	COG4106	trans-aconitate 2-methyltransferase activity
A4V05_RS04540	COG3475	LICD family
A4V05_RS04545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V05_RS04555	COG3475	LICD family
A4V05_RS04560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V05_RS04570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V05_RS04575	COG3475	LICD family
A4V05_RS04580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V05_RS04590	COG2166	iron-sulfur cluster assembly
A4V05_RS04595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V05_RS04605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V05_RS04610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V05_RS04615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4V05_RS04620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V05_RS04625	COG1131	(ABC) transporter
A4V05_RS04640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V05_RS04655	COG1215	transferase activity, transferring glycosyl groups
A4V05_RS04665	COG2967	ApaG domain
A4V05_RS04675	COG1522	sequence-specific DNA binding
A4V05_RS04680	COG0436	Aminotransferase
A4V05_RS04695	COG0423	glycine-tRNA ligase activity
A4V05_RS04705	COG0656	L-ascorbic acid biosynthetic process
A4V05_RS04720	COG2304	oxidoreductase activity
A4V05_RS04735	COG0714	Associated with various cellular activities
A4V05_RS04740	COG0154	amidase activity
A4V05_RS04745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4V05_RS04785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS04790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS04800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4V05_RS04800	COG2755	lipolytic protein G-D-S-L family
A4V05_RS04830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V05_RS04840	COG0656	L-ascorbic acid biosynthetic process
A4V05_RS04850	COG0667	Aldo Keto reductase
A4V05_RS04855	COG1408	metallophosphoesterase
A4V05_RS04875	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4V05_RS04880	COG0789	Transcriptional regulator
A4V05_RS04900	COG0534	Mate efflux family protein
A4V05_RS04920	COG1091	dTDP-4-dehydrorhamnose reductase activity
A4V05_RS04935	COG1837	Belongs to the UPF0109 family
A4V05_RS04945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V05_RS04950	COG0363	glucosamine-6-phosphate deaminase activity
A4V05_RS04965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4V05_RS04975	COG1741	Belongs to the pirin family
A4V05_RS04995	COG1070	Carbohydrate kinase
A4V05_RS05010	COG0738	Major facilitator superfamily
A4V05_RS05025	COG1595	DNA-templated transcription, initiation
A4V05_RS05045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4V05_RS05070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS05080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V05_RS05085	COG2132	Multicopper oxidase
A4V05_RS05090	COG0697	spore germination
A4V05_RS05095	COG3586	endonuclease activity
A4V05_RS05110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V05_RS05115	COG4608	Belongs to the ABC transporter superfamily
A4V05_RS05120	COG0444	Belongs to the ABC transporter superfamily
A4V05_RS05125	COG4166	transmembrane transport
A4V05_RS05130	COG4239	(ABC) transporter, permease
A4V05_RS05135	COG0601	transmembrane transport
A4V05_RS05150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4V05_RS05155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V05_RS05160	COG3738	Protein conserved in bacteria
A4V05_RS05165	COG0151	Belongs to the GarS family
A4V05_RS05180	COG0811	peptide transport
A4V05_RS05190	COG0242	peptide deformylase activity
A4V05_RS05230	COG2010	Cytochrome c
A4V05_RS05240	COG3258	Cytochrome c
A4V05_RS05250	COG3274	enterobacterial common antigen metabolic process
A4V05_RS05255	COG0538	isocitrate dehydrogenase activity
A4V05_RS05275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4V05_RS05280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4V05_RS05285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4V05_RS05295	COG0668	transmembrane transport
A4V05_RS05300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V05_RS05300	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A4V05_RS05305	COG0805	protein transport
A4V05_RS05310	COG1968	undecaprenyl-diphosphatase activity
A4V05_RS05330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4V05_RS05340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V05_RS05350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4V05_RS05360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4V05_RS05370	COG1408	metallophosphoesterase
A4V05_RS05395	COG4974	Belongs to the 'phage' integrase family
A4V05_RS05415	COG1454	alcohol dehydrogenase
A4V05_RS05420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4V05_RS05435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V05_RS05435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4V05_RS05440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4V05_RS05480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V05_RS05490	COG4607	ABC-type enterochelin transport system periplasmic component
A4V05_RS05495	COG4604	ABC transporter, ATP-binding protein
A4V05_RS05500	COG4605	iron ion homeostasis
A4V05_RS05505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V05_RS05550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V05_RS05550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V05_RS05565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4V05_RS05575	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V05_RS05595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V05_RS05610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4V05_RS05635	COG0519	Catalyzes the synthesis of GMP from XMP
A4V05_RS05635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4V05_RS05640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V05_RS05675	COG0646	methionine synthase
A4V05_RS05675	COG1410	methionine synthase
A4V05_RS05680	COG2966	Psort location CytoplasmicMembrane, score
A4V05_RS05685	COG3610	response to peptide
A4V05_RS05695	COG0460	homoserine dehydrogenase
A4V05_RS05700	COG0527	aspartate kinase activity
A4V05_RS05710	COG5522	Integral membrane protein (intg_mem_TP0381)
A4V05_RS05725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V05_RS05735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V05_RS05740	COG1194	a g-specific adenine glycosylase
A4V05_RS05745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A4V05_RS05750	COG0574	Belongs to the PEP-utilizing enzyme family
A4V05_RS05750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V05_RS05760	COG0166	Belongs to the GPI family
A4V05_RS05770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V05_RS05780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V05_RS05780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V05_RS05815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V05_RS05820	COG2818	Glycosylase
A4V05_RS05840	COG3033	Beta-eliminating lyase
A4V05_RS05855	COG0072	phenylalanine-tRNA ligase activity
A4V05_RS05855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V05_RS05875	COG0326	Molecular chaperone. Has ATPase activity
A4V05_RS05880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V05_RS05885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V05_RS05890	COG1959	2 iron, 2 sulfur cluster binding
A4V05_RS05905	COG0352	thiamine-phosphate diphosphorylase activity
A4V05_RS05910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4V05_RS05935	COG1703	isobutyryl-CoA mutase activity
A4V05_RS05955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4V05_RS05965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V05_RS05970	COG0418	dihydroorotase activity
A4V05_RS05985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V05_RS06005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V05_RS06020	COG0534	Mate efflux family protein
A4V05_RS06025	COG0489	protein tyrosine kinase activity
A4V05_RS06040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V05_RS06045	COG0339	signal peptide processing
A4V05_RS06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V05_RS06060	COG1538	Outer membrane efflux protein
A4V05_RS06080	COG4112	unkown
A4V05_RS06095	COG0038	chloride channel
A4V05_RS06110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V05_RS06115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V05_RS06120	COG0586	Pfam SNARE associated Golgi protein
A4V05_RS06195	COG1518	maintenance of DNA repeat elements
A4V05_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
A4V05_RS06250	COG0753	catalase activity
A4V05_RS06270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V05_RS06275	COG1592	Rubrerythrin
A4V05_RS06280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V05_RS06300	COG0489	protein tyrosine kinase activity
A4V05_RS06310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V05_RS06320	COG0438	transferase activity, transferring glycosyl groups
A4V05_RS06330	COG0438	transferase activity, transferring glycosyl groups
A4V05_RS06370	COG0110	maltose O-acetyltransferase activity
A4V05_RS06380	COG1216	Glycosyl transferase, family 2
A4V05_RS06385	COG1216	Glycosyl transferase, family 2
A4V05_RS06430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V05_RS06440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V05_RS06440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V05_RS06445	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4V05_RS06465	COG0281	malic enzyme
A4V05_RS06465	COG0280	phosphate acetyltransferase
A4V05_RS06480	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V05_RS06485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V05_RS06500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V05_RS06535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V05_RS06545	COG1063	alcohol dehydrogenase
A4V05_RS06560	COG0714	Associated with various cellular activities
A4V05_RS06570	COG0193	aminoacyl-tRNA hydrolase activity
A4V05_RS06575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4V05_RS06590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V05_RS06630	COG0375	protein maturation
A4V05_RS06655	COG0778	Nitroreductase
A4V05_RS06660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V05_RS06680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V05_RS06680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V05_RS06690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V05_RS06690	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V05_RS06710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS06715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V05_RS06720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4V05_RS06755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V05_RS06760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V05_RS06775	COG0318	PFAM AMP-dependent synthetase and ligase
A4V05_RS06800	COG0339	signal peptide processing
A4V05_RS06810	COG0018	arginyl-trna synthetase
A4V05_RS06850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V05_RS06855	COG0653	protein targeting
A4V05_RS07055	COG0494	nUDIX hydrolase
A4V05_RS07060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V05_RS07065	COG1131	(ABC) transporter
A4V05_RS07085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4V05_RS07090	COG0564	pseudouridine synthase activity
A4V05_RS07105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V05_RS07110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V05_RS07120	COG0513	Belongs to the DEAD box helicase family
A4V05_RS07135	COG0673	inositol 2-dehydrogenase activity
A4V05_RS07155	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4V05_RS07175	COG1971	Probably functions as a manganese efflux pump
A4V05_RS07205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V05_RS07230	COG0442	prolyl-tRNA aminoacylation
A4V05_RS07260	COG0531	amino acid
A4V05_RS07265	COG2066	Belongs to the glutaminase family
A4V05_RS07280	COG1115	amino acid carrier protein
A4V05_RS07290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V05_RS07295	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V05_RS07300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V05_RS07305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V05_RS07325	COG2226	methyltransferase
A4V05_RS07330	COG0534	Mate efflux family protein
A4V05_RS07345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V05_RS07350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V05_RS07355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS07375	COG1121	(ABC) transporter
A4V05_RS07380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4V05_RS07385	COG3880	PFAM UvrB UvrC protein
A4V05_RS07390	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A4V05_RS07395	COG0542	response to heat
A4V05_RS07410	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V05_RS07415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V05_RS07430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V05_RS07430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V05_RS07445	COG0180	Tryptophanyl-tRNA synthetase
A4V05_RS07455	COG1692	metallophosphoesterase
A4V05_RS07465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V05_RS07480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V05_RS07490	COG2816	NAD+ diphosphatase activity
A4V05_RS07500	COG0156	8-amino-7-oxononanoate synthase activity
A4V05_RS07520	COG0515	serine threonine protein kinase
A4V05_RS07520	COG3266	domain, Protein
A4V05_RS07565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4V05_RS07575	COG3189	MarR family transcriptional regulator
A4V05_RS07585	COG0181	hydroxymethylbilane synthase activity
A4V05_RS07590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4V05_RS07600	COG1469	GTP cyclohydrolase I activity
A4V05_RS07605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V05_RS07610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4V05_RS07615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4V05_RS07620	COG1940	carbohydrate kinase activity
A4V05_RS07635	COG0494	nUDIX hydrolase
A4V05_RS07640	COG1566	PFAM secretion protein HlyD family protein
A4V05_RS07645	COG0577	efflux transmembrane transporter activity
A4V05_RS07645	COG1136	(ABC) transporter
A4V05_RS07650	COG0577	efflux transmembrane transporter activity
A4V05_RS07650	COG1136	(ABC) transporter
A4V05_RS07655	COG1538	Outer membrane efflux protein
A4V05_RS07670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V05_RS07680	COG1720	tRNA m6t6A37 methyltransferase activity
A4V05_RS07685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V05_RS07690	COG0540	Belongs to the ATCase OTCase family
A4V05_RS07695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4V05_RS07715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V05_RS07720	COG2957	Belongs to the agmatine deiminase family
A4V05_RS07730	COG0750	zinc metalloprotease
A4V05_RS07740	COG3119	arylsulfatase activity
A4V05_RS07750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V05_RS07750	COG1918	ferrous iron import across plasma membrane
A4V05_RS07810	COG1475	DNA binding
A4V05_RS07845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4V05_RS07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V05_RS07865	COG0601	transmembrane transport
A4V05_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V05_RS07920	COG1132	(ABC) transporter
A4V05_RS07925	COG1132	(ABC) transporter
A4V05_RS07940	COG1127	ABC transporter
A4V05_RS07945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4V05_RS07975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4V05_RS07990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4V05_RS07995	COG0504	CTP synthase activity
A4V05_RS08000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4V05_RS08025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS08035	COG1322	Protein conserved in bacteria
A4V05_RS08040	COG0546	phosphoglycolate phosphatase activity
A4V05_RS08045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V05_RS08055	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4V05_RS08080	COG2234	aminopeptidase activity
A4V05_RS08085	COG2755	lipolytic protein G-D-S-L family
A4V05_RS08085	COG0657	acetylesterase activity
A4V05_RS08090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V05_RS08110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4V05_RS08130	COG0335	large ribosomal subunit rRNA binding
A4V05_RS08140	COG0346	lactoylglutathione lyase activity
A4V05_RS08155	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4V05_RS08160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V05_RS08165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4V05_RS08165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4V05_RS08170	COG0427	acetyl-CoA hydrolase
A4V05_RS08180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4V05_RS08190	COG0205	6-phosphofructokinase activity
A4V05_RS08200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4V05_RS08205	COG0028	Belongs to the TPP enzyme family
A4V05_RS08220	COG1204	response to ionizing radiation
A4V05_RS08275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V05_RS08290	COG0471	metal ion transport
A4V05_RS08300	COG0351	phosphomethylpyrimidine kinase
A4V05_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
A4V05_RS08365	COG0242	peptide deformylase activity
A4V05_RS08370	COG1063	alcohol dehydrogenase
A4V05_RS08380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V05_RS08385	COG1393	Belongs to the ArsC family
A4V05_RS08390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4V05_RS08400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4V05_RS08410	COG1187	pseudouridine synthase activity
A4V05_RS08415	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V05_RS08420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4V05_RS08430	COG0539	negative regulation of cytoplasmic translation
A4V05_RS08480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V05_RS08485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4V05_RS08490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V05_RS08495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V05_RS08535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V05_RS08560	COG0662	Cupin 2, conserved barrel domain protein
A4V05_RS08560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4V05_RS08570	COG0416	fatty acid biosynthetic process
A4V05_RS08575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4V05_RS08585	COG0537	adenosine 5'-monophosphoramidase activity
A4V05_RS08590	COG0009	L-threonylcarbamoyladenylate synthase
A4V05_RS08595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V05_RS08600	COG0228	four-way junction DNA binding
A4V05_RS08625	COG1862	Preprotein translocase
A4V05_RS08630	COG0343	queuine tRNA-ribosyltransferase activity
A4V05_RS08635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V05_RS08645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4V05_RS08650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V05_RS08655	COG0776	regulation of translation
A4V05_RS08690	COG0811	peptide transport
A4V05_RS08710	COG3250	beta-galactosidase activity
A4V05_RS08715	COG0525	valine-tRNA ligase activity
A4V05_RS08730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4V05_RS08735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V05_RS08740	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V05_RS08745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V05_RS08750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4V05_RS08755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V05_RS08765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4V05_RS08770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V05_RS08775	COG0089	rRNA binding
A4V05_RS08780	COG0088	Forms part of the polypeptide exit tunnel
A4V05_RS08785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V05_RS08790	COG0051	transcription antitermination factor activity, RNA binding
A4V05_RS08795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V05_RS08800	COG0049	tRNA binding
A4V05_RS08805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V05_RS08810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V05_RS08820	COG3852	Histidine kinase
A4V05_RS08825	COG2204	response regulator
A4V05_RS08835	COG1722	exodeoxyribonuclease VII activity
A4V05_RS08840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V05_RS08855	COG0795	lipopolysaccharide-transporting ATPase activity
A4V05_RS08860	COG1160	GTP binding
A4V05_RS08865	COG0444	Belongs to the ABC transporter superfamily
A4V05_RS08885	COG0577	efflux transmembrane transporter activity
A4V05_RS08885	COG1136	(ABC) transporter
A4V05_RS08895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V05_RS08940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V05_RS08950	COG0799	negative regulation of ribosome biogenesis
A4V05_RS08955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V05_RS09015	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A4V05_RS09030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4V05_RS09040	COG0300	oxidoreductase activity
A4V05_RS09060	COG0038	chloride channel
A4V05_RS09070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS09085	COG0076	glutamate decarboxylase activity
A4V05_RS09100	COG0167	dihydroorotate dehydrogenase activity
A4V05_RS09105	COG0352	thiamine-phosphate diphosphorylase activity
A4V05_RS09125	COG1253	flavin adenine dinucleotide binding
A4V05_RS09130	COG1253	flavin adenine dinucleotide binding
A4V05_RS09140	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V05_RS09145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V05_RS09150	COG0110	maltose O-acetyltransferase activity
A4V05_RS09175	COG0101	tRNA pseudouridine synthase activity
A4V05_RS09180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V05_RS09215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS09220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4V05_RS09240	COG1136	(ABC) transporter
A4V05_RS09245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4V05_RS09255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V05_RS09280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS09285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4V05_RS09290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4V05_RS09305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V05_RS09310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4V05_RS09325	COG2814	Major facilitator Superfamily
A4V05_RS09340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V05_RS09345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4V05_RS09345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4V05_RS09350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4V05_RS09355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V05_RS09360	COG0552	protein localization to endoplasmic reticulum
A4V05_RS09365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V05_RS09385	COG1546	Belongs to the CinA family
A4V05_RS09385	COG1058	Belongs to the CinA family
A4V05_RS09395	COG0456	acetyltransferase
A4V05_RS09420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V05_RS09425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V05_RS09430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V05_RS09435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V05_RS09450	COG0758	DNA mediated transformation
A4V05_RS09455	COG1686	Belongs to the peptidase S11 family
A4V05_RS09460	COG0012	GTP binding
A4V05_RS09465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4V05_RS09475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V05_RS09475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V05_RS09490	COG3119	arylsulfatase activity
A4V05_RS09515	COG2259	Doxx family
A4V05_RS09520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V05_RS09550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V05_RS09570	COG2326	polyphosphate kinase activity
A4V05_RS09575	COG1349	DNA-binding transcription factor activity
A4V05_RS09590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V05_RS09595	COG1162	GTPase activity
A4V05_RS09610	COG0742	ribosomal rna small subunit methyltransferase
A4V05_RS09625	COG2326	polyphosphate kinase activity
A4V05_RS09640	COG5434	Belongs to the glycosyl hydrolase 28 family
A4V05_RS09650	COG1073	alpha beta
A4V05_RS09655	COG0802	atpase or kinase
A4V05_RS09660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4V05_RS09665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V05_RS09670	COG0735	belongs to the Fur family
A4V05_RS09675	COG0396	ATPase activity
A4V05_RS09680	COG0719	Fe-S assembly protein
A4V05_RS09685	COG0719	Fe-S assembly protein
A4V05_RS09700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V05_RS09740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V05_RS09760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V05_RS09765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V05_RS09770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V05_RS09775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V05_RS09780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V05_RS09785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4V05_RS09795	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V05_RS09865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V05_RS09895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V05_RS09900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4V05_RS09910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V05_RS09920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V05_RS09930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V05_RS09935	COG0047	phosphoribosylformylglycinamidine synthase activity
A4V05_RS09945	COG1363	Peptidase, m42
A4V05_RS09965	COG1077	Cell shape determining protein MreB Mrl
A4V05_RS09970	COG1530	ribonuclease E activity
A4V05_RS10000	COG0848	biopolymer transport protein
A4V05_RS10015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V05_RS10035	COG0134	indole-3-glycerol-phosphate synthase activity
A4V05_RS10040	COG0792	nuclease activity
A4V05_RS10050	COG1253	flavin adenine dinucleotide binding
A4V05_RS10060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V05_RS10075	COG0137	argininosuccinate synthase activity
A4V05_RS10090	COG0149	triose-phosphate isomerase activity
A4V05_RS10125	COG1040	competence protein
A4V05_RS10135	COG3956	TIGRFAM MazG family protein
A4V05_RS10160	COG1663	tetraacyldisaccharide 4'-kinase activity
A4V05_RS10170	COG0612	Peptidase, M16
A4V05_RS10190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V05_RS10215	COG0673	inositol 2-dehydrogenase activity
A4V05_RS10220	COG3034	peptidoglycan biosynthetic process
A4V05_RS10240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V05_RS10245	COG0424	maF-like protein
A4V05_RS10250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V05_RS10280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4V05_RS10290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V05_RS10300	COG0571	ribonuclease III activity
A4V05_RS10310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4V05_RS10345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V05_RS10360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V05_RS10380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V05_RS10395	COG2226	methyltransferase
A4V05_RS10405	COG2076	Multidrug Resistance protein
A4V05_RS10455	COG3152	Membrane
A4V05_RS10485	COG2255	four-way junction helicase activity
A4V05_RS10490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V05_RS10495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4V05_RS10500	COG1215	transferase activity, transferring glycosyl groups
A4V05_RS10505	COG1216	Glycosyl transferase, family 2
A4V05_RS10505	COG0463	Glycosyl transferase, family 2
A4V05_RS10530	COG0438	transferase activity, transferring glycosyl groups
A4V05_RS10540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4V05_RS10550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V05_RS10555	COG0482	sulfurtransferase activity
A4V05_RS10560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V05_RS10570	COG2860	membrane
A4V05_RS10575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4V05_RS10580	COG2001	Belongs to the MraZ family
A4V05_RS10585	COG0275	rRNA processing
A4V05_RS10595	COG0768	penicillin binding
A4V05_RS10600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V05_RS10605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V05_RS10610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V05_RS10615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V05_RS10625	COG0772	Belongs to the SEDS family
A4V05_RS10630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V05_RS10635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V05_RS10640	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4V05_RS10650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V05_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V05_RS10660	COG0321	lipoyl(octanoyl) transferase activity
A4V05_RS10665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V05_RS10670	COG0066	3-isopropylmalate dehydratase activity
A4V05_RS10680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS10690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V05_RS10700	COG4608	Belongs to the ABC transporter superfamily
A4V05_RS10710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V05_RS10715	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V05_RS10725	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4V05_RS10740	COG1137	ATPase activity
A4V05_RS10750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V05_RS10765	COG1733	regulation of RNA biosynthetic process
A4V05_RS10775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V05_RS10790	COG0017	Asparaginyl-tRNA synthetase
A4V05_RS10800	COG3118	belongs to the thioredoxin family
A4V05_RS10850	COG0583	DNA-binding transcription factor activity
A4V05_RS10855	COG2855	membrane
A4V05_RS10860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4V05_RS10875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V05_RS10885	COG0602	queuosine metabolic process
A4V05_RS10890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4V05_RS10895	COG0217	transcriptional regulatory protein
A4V05_RS10900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4V05_RS10905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V05_RS10905	COG4651	solute:proton antiporter activity
A4V05_RS10915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V05_RS10920	COG4864	UPF0365 protein
A4V05_RS10930	COG2022	thiamine diphosphate biosynthetic process
A4V05_RS10935	COG0531	amino acid
A4V05_RS10945	COG0628	permease
A4V05_RS10950	COG0019	diaminopimelate decarboxylase activity
A4V05_RS10955	COG0191	fructose-bisphosphate aldolase activity
A4V05_RS10960	COG1217	gtp-binding protein TYPA
A4V05_RS10990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V05_RS11045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V05_RS11050	COG0517	IMP dehydrogenase activity
A4V05_RS11050	COG0516	GMP reductase activity
A4V05_RS11055	COG0519	Catalyzes the synthesis of GMP from XMP
A4V05_RS11055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4V05_RS11065	COG0546	phosphoglycolate phosphatase activity
A4V05_RS11080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4V05_RS11095	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4V05_RS11100	COG0196	riboflavin kinase activity
A4V05_RS11105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V05_RS11120	COG1408	metallophosphoesterase
A4V05_RS11130	COG1216	Glycosyl transferase, family 2
A4V05_RS11130	COG1442	glycosyl transferase family 8
A4V05_RS11140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V05_RS11145	COG1216	Glycosyl transferase, family 2
A4V05_RS11170	COG2755	lipolytic protein G-D-S-L family
A4V05_RS11170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4V05_RS11185	COG0490	domain, Protein
A4V05_RS11185	COG0471	metal ion transport
A4V05_RS11230	COG0588	phosphoglycerate mutase activity
A4V05_RS11235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V05_RS11245	COG0477	Major facilitator Superfamily
A4V05_RS11250	COG1607	acyl-coa hydrolase
A4V05_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
A4V05_RS11270	COG1525	nuclease
A4V05_RS11285	COG1475	DNA binding
A4V05_RS11290	COG3969	phosphoadenosine phosphosulfate
A4V05_RS11305	COG3645	SOS response
A4V05_RS11435	COG0305	Participates in initiation and elongation during chromosome replication
A4V05_RS11520	COG0473	3-isopropylmalate dehydrogenase activity
A4V05_RS11545	COG2873	o-acetylhomoserine
A4V05_RS11550	COG0535	radical SAM domain protein
A4V05_RS11555	COG0535	radical SAM domain protein
A4V05_RS11570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V05_RS11575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4V05_RS11585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V05_RS11595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V05_RS11595	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V05_RS11595	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V05_RS11595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V05_RS11605	COG1733	regulation of RNA biosynthetic process
A4V05_RS11615	COG0107	imidazoleglycerol-phosphate synthase activity
A4V05_RS11625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V05_RS11635	COG1643	Atp-dependent helicase
A4V05_RS11640	COG0440	acetolactate synthase activity
A4V05_RS11645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V05_RS11660	COG0445	tRNA wobble uridine modification
A4V05_RS11670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V05_RS11670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V05_RS11675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4V05_RS11685	COG0592	DNA-directed DNA polymerase activity
A4V05_RS11710	COG0791	NLP P60 protein
A4V05_RS11710	COG1388	LysM domain
A4V05_RS11715	COG0084	hydrolase, TatD family'
A4V05_RS11725	COG3250	beta-galactosidase activity
A4V05_RS11745	COG2205	protein histidine kinase activity
A4V05_RS11750	COG0745	RESPONSE REGULATOR receiver
A4V05_RS11760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4V05_RS11770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4V05_RS11790	COG0542	response to heat
A4V05_RS11835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V05_RS11845	COG0659	secondary active sulfate transmembrane transporter activity
A4V05_RS11850	COG0165	Argininosuccinate lyase
A4V05_RS11865	COG0148	phosphopyruvate hydratase activity
A4V05_RS11870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4V05_RS11880	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4V05_RS11890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V05_RS11895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V05_RS11925	COG2985	domain, Protein
A4V05_RS11925	COG0490	domain, Protein
A4V05_RS11940	COG0471	metal ion transport
A4V05_RS11965	COG2194	sulfuric ester hydrolase activity
A4V05_RS11975	COG1592	Rubrerythrin
A4V05_RS11985	COG1363	Peptidase, m42
A4V05_RS11990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V05_RS12000	COG1785	Belongs to the alkaline phosphatase family
A4V05_RS12005	COG1970	mechanosensitive ion channel activity
A4V05_RS12010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V05_RS12020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4V05_RS12030	COG2217	Heavy metal translocating P-type atpase
A4V05_RS12035	COG0497	DNA recombination
A4V05_RS12040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V05_RS12040	COG0321	lipoyl(octanoyl) transferase activity
A4V05_RS12045	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A4V05_RS12075	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4V05_RS12080	COG0022	dehydrogenase e1 component
A4V05_RS12085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V05_RS12095	COG0789	Transcriptional regulator
A4V05_RS12100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V05_RS12105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family