locus-tag	class	description
D3M96_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3M96_RS00010	COG0592	DNA-directed DNA polymerase activity
D3M96_RS00050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS00070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3M96_RS00075	COG0583	DNA-binding transcription factor activity
D3M96_RS00085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3M96_RS00095	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS00110	COG0318	PFAM AMP-dependent synthetase and ligase
D3M96_RS00120	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3M96_RS00120	COG0596	Alpha beta hydrolase
D3M96_RS00125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS00140	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS00150	COG0697	spore germination
D3M96_RS00155	COG0583	DNA-binding transcription factor activity
D3M96_RS00165	COG3842	ATPase activity
D3M96_RS00175	COG0436	Aminotransferase
D3M96_RS00185	COG0523	cobalamin synthesis protein
D3M96_RS00245	COG1846	Transcriptional regulator
D3M96_RS00265	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3M96_RS00270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3M96_RS00275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D3M96_RS00285	COG4638	Rieske (2fe-2S)
D3M96_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS00365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3M96_RS00385	COG4608	Belongs to the ABC transporter superfamily
D3M96_RS00390	COG0444	Belongs to the ABC transporter superfamily
D3M96_RS00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3M96_RS00400	COG0601	transmembrane transport
D3M96_RS00405	COG0747	negative chemotaxis
D3M96_RS00410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3M96_RS00415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3M96_RS00460	COG4149	molybdate abc transporter
D3M96_RS00475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3M96_RS00485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3M96_RS00495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS00510	COG0028	Belongs to the TPP enzyme family
D3M96_RS00515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS00540	COG0551	DNA topoisomerase type I activity
D3M96_RS00540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3M96_RS00550	COG2922	Belongs to the Smg family
D3M96_RS00565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3M96_RS00570	COG0183	Belongs to the thiolase family
D3M96_RS00575	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D3M96_RS00580	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3M96_RS00610	COG0018	arginyl-trna synthetase
D3M96_RS00640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3M96_RS00650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3M96_RS00655	COG4774	siderophore transport
D3M96_RS00675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3M96_RS00680	COG1280	lysine exporter protein (LysE YggA)
D3M96_RS00685	COG0513	Belongs to the DEAD box helicase family
D3M96_RS00695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D3M96_RS00710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3M96_RS00725	COG0154	amidase activity
D3M96_RS00770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3M96_RS00775	COG1127	ABC transporter
D3M96_RS00795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3M96_RS00800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS00810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS00850	COG0583	DNA-binding transcription factor activity
D3M96_RS00880	COG1254	Belongs to the acylphosphatase family
D3M96_RS00890	COG2358	TRAP transporter, solute receptor (TAXI family
D3M96_RS00900	COG0564	pseudouridine synthase activity
D3M96_RS00905	COG0252	asparaginase activity
D3M96_RS00930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3M96_RS00935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3M96_RS00940	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS00960	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS00985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS01000	COG0758	DNA mediated transformation
D3M96_RS01005	COG0242	peptide deformylase activity
D3M96_RS01010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3M96_RS01015	COG0697	spore germination
D3M96_RS01030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS01045	COG4336	lyase activity
D3M96_RS01050	COG0583	DNA-binding transcription factor activity
D3M96_RS01055	COG0859	PFAM glycosyl transferase family 9
D3M96_RS01065	COG1278	Cold shock
D3M96_RS01070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3M96_RS01075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3M96_RS01080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3M96_RS01080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3M96_RS01090	COG1686	Belongs to the peptidase S11 family
D3M96_RS01100	COG2921	Belongs to the UPF0250 family
D3M96_RS01105	COG0321	lipoyl(octanoyl) transferase activity
D3M96_RS01110	COG1024	Enoyl-CoA hydratase
D3M96_RS01115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3M96_RS01125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3M96_RS01170	COG0826	peptidase U32
D3M96_RS01180	COG3154	lipid carrier protein
D3M96_RS01205	COG0134	indole-3-glycerol-phosphate synthase activity
D3M96_RS01210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3M96_RS01215	COG0512	Glutamine amidotransferase of anthranilate synthase
D3M96_RS01225	COG0546	phosphoglycolate phosphatase activity
D3M96_RS01235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3M96_RS01240	COG2967	ApaG domain
D3M96_RS01250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3M96_RS01255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3M96_RS01265	COG0840	transmembrane signaling receptor activity
D3M96_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS01280	COG1535	isochorismatase
D3M96_RS01280	COG3433	isochorismatase activity
D3M96_RS01285	COG1169	isochorismate synthase
D3M96_RS01300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3M96_RS01305	COG3433	isochorismatase activity
D3M96_RS01305	COG1535	isochorismatase
D3M96_RS01310	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3M96_RS01325	COG0411	ABC transporter
D3M96_RS01340	COG0683	leucine binding
D3M96_RS01355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3M96_RS01390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3M96_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3M96_RS01400	COG2819	hydrolase of the alpha beta superfamily
D3M96_RS01405	COG0513	Belongs to the DEAD box helicase family
D3M96_RS01410	COG2814	Major facilitator Superfamily
D3M96_RS01420	COG0583	DNA-binding transcription factor activity
D3M96_RS01430	COG1253	flavin adenine dinucleotide binding
D3M96_RS01455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3M96_RS01460	COG2311	Membrane
D3M96_RS01485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3M96_RS01505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3M96_RS01510	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3M96_RS01520	COG0583	DNA-binding transcription factor activity
D3M96_RS01525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS01530	COG1126	abc transporter atp-binding protein
D3M96_RS01535	COG0765	amino acid transport
D3M96_RS01540	COG0765	amino acid transport
D3M96_RS01545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3M96_RS01550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3M96_RS01565	COG3391	amine dehydrogenase activity
D3M96_RS01575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3M96_RS01600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D3M96_RS01605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3M96_RS01610	COG0210	DNA helicase
D3M96_RS01630	COG0070	glutamate synthase
D3M96_RS01630	COG0069	glutamate synthase activity
D3M96_RS01630	COG0067	glutamate synthase
D3M96_RS01635	COG1024	Enoyl-CoA hydratase
D3M96_RS01645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3M96_RS01650	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3M96_RS01675	COG2918	glutathione biosynthetic process
D3M96_RS01685	COG2197	response regulator
D3M96_RS01690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3M96_RS01700	COG2223	nitrite transmembrane transporter activity
D3M96_RS01705	COG2860	membrane
D3M96_RS01710	COG1346	cytolysis
D3M96_RS01725	COG0251	oxidation-reduction process
D3M96_RS01745	COG0745	RESPONSE REGULATOR receiver
D3M96_RS01760	COG1280	lysine exporter protein (LysE YggA)
D3M96_RS01770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3M96_RS01785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3M96_RS01800	COG2096	Adenosyltransferase
D3M96_RS01815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3M96_RS01820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D3M96_RS01825	COG0583	DNA-binding transcription factor activity
D3M96_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS01845	COG0523	cobalamin synthesis protein
D3M96_RS01850	COG0735	belongs to the Fur family
D3M96_RS01860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3M96_RS01865	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3M96_RS01870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D3M96_RS01880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3M96_RS01885	COG1560	Kdo2-lipid A biosynthetic process
D3M96_RS01895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3M96_RS01900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3M96_RS01905	COG1950	PFAM Membrane protein of
D3M96_RS01940	COG0275	rRNA processing
D3M96_RS01945	COG0730	response to heat
D3M96_RS01950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3M96_RS01955	COG0129	dihydroxy-acid dehydratase activity
D3M96_RS01965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS01975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS01990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3M96_RS02010	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS02020	COG0628	permease
D3M96_RS02165	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS02170	COG1846	Transcriptional regulator
D3M96_RS02185	COG4774	siderophore transport
D3M96_RS02190	COG4607	ABC-type enterochelin transport system periplasmic component
D3M96_RS02195	COG4604	ABC transporter, ATP-binding protein
D3M96_RS02200	COG4605	iron ion homeostasis
D3M96_RS02205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3M96_RS02215	COG2375	cellular response to nickel ion
D3M96_RS02215	COG1132	(ABC) transporter
D3M96_RS02220	COG0277	FAD linked oxidase domain protein
D3M96_RS02225	COG1304	FMN binding
D3M96_RS02230	COG2186	Transcriptional regulator
D3M96_RS02245	COG2188	Transcriptional regulator
D3M96_RS02250	COG1522	sequence-specific DNA binding
D3M96_RS02255	COG3844	kynureninase activity
D3M96_RS02260	COG1113	amino acid transport
D3M96_RS02265	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3M96_RS02270	COG1349	DNA-binding transcription factor activity
D3M96_RS02290	COG0395	ABC-type sugar transport system, permease component
D3M96_RS02305	COG0861	Integral membrane protein TerC family
D3M96_RS02310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS02325	COG1671	Belongs to the UPF0178 family
D3M96_RS02335	COG1418	mRNA catabolic process
D3M96_RS02345	COG4948	Mandelate Racemase Muconate Lactonizing
D3M96_RS02370	COG0154	amidase activity
D3M96_RS02380	COG0583	DNA-binding transcription factor activity
D3M96_RS02405	COG0326	Molecular chaperone. Has ATPase activity
D3M96_RS02425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3M96_RS02440	COG3328	transposase activity
D3M96_RS02445	COG1652	LysM domain
D3M96_RS02460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3M96_RS02470	COG0582	viral genome integration into host DNA
D3M96_RS02485	COG0583	DNA-binding transcription factor activity
D3M96_RS02525	COG1459	type II secretion system
D3M96_RS02565	COG2165	general secretion pathway protein
D3M96_RS02620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS02690	COG0667	Aldo Keto reductase
D3M96_RS02775	COG2003	Belongs to the UPF0758 family
D3M96_RS02830	COG3177	Filamentation induced by cAMP protein fic
D3M96_RS02975	COG0270	DNA (cytosine-5-)-methyltransferase activity
D3M96_RS02985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3M96_RS03005	COG0629	single-stranded DNA binding
D3M96_RS03040	COG1192	Involved in chromosome partitioning
D3M96_RS03055	COG0582	viral genome integration into host DNA
D3M96_RS03105	COG0629	single-stranded DNA binding
D3M96_RS03110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3M96_RS03300	COG2003	Belongs to the UPF0758 family
D3M96_RS03355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3M96_RS03360	COG0542	response to heat
D3M96_RS03410	COG3177	Filamentation induced by cAMP protein fic
D3M96_RS03455	COG0583	DNA-binding transcription factor activity
D3M96_RS03500	COG0583	DNA-binding transcription factor activity
D3M96_RS03505	COG0387	Pfam Sodium calcium exchanger
D3M96_RS03520	COG0477	Major facilitator Superfamily
D3M96_RS03525	COG0235	Class ii aldolase
D3M96_RS03535	COG3391	amine dehydrogenase activity
D3M96_RS03540	COG0590	tRNA wobble adenosine to inosine editing
D3M96_RS03550	COG3257	ureidoglycine aminohydrolase activity
D3M96_RS03555	COG0583	DNA-binding transcription factor activity
D3M96_RS03560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D3M96_RS03575	COG0489	protein tyrosine kinase activity
D3M96_RS03600	COG2081	HI0933 family
D3M96_RS03605	COG0509	glycine decarboxylation via glycine cleavage system
D3M96_RS03615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D3M96_RS03620	COG1765	OsmC-like protein
D3M96_RS03625	COG3278	Belongs to the heme-copper respiratory oxidase family
D3M96_RS03650	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3M96_RS03655	COG0469	pyruvate kinase activity
D3M96_RS03660	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D3M96_RS03670	COG2084	Dehydrogenase
D3M96_RS03675	COG3622	Belongs to the hyi family
D3M96_RS03680	COG3960	tartronate-semialdehyde synthase activity
D3M96_RS03685	COG0583	DNA-binding transcription factor activity
D3M96_RS03695	COG2233	PERMEase
D3M96_RS03700	COG1942	4-Oxalocrotonate Tautomerase
D3M96_RS03705	COG0235	Class ii aldolase
D3M96_RS03715	COG3648	Uricase
D3M96_RS03715	COG3195	allantoin biosynthetic process
D3M96_RS03725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3M96_RS03730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3M96_RS03745	COG0438	transferase activity, transferring glycosyl groups
D3M96_RS03755	COG0438	transferase activity, transferring glycosyl groups
D3M96_RS03765	COG0277	FAD linked oxidase domain protein
D3M96_RS03775	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3M96_RS03780	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D3M96_RS03790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3M96_RS03800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3M96_RS03810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D3M96_RS03825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3M96_RS03830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3M96_RS03835	COG0193	aminoacyl-tRNA hydrolase activity
D3M96_RS03845	COG0012	GTP binding
D3M96_RS03890	COG0488	(ABC) transporter
D3M96_RS03905	COG0288	reversible hydration of carbon dioxide
D3M96_RS03910	COG0583	DNA-binding transcription factor activity
D3M96_RS03930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3M96_RS03940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3M96_RS03950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3M96_RS03955	COG3088	subunit of a heme lyase
D3M96_RS03960	COG4235	cytochrome complex assembly
D3M96_RS03965	COG0785	Cytochrome C biogenesis protein
D3M96_RS03975	COG2169	Transcriptional regulator
D3M96_RS03975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3M96_RS03995	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS04005	COG0411	ABC transporter
D3M96_RS04015	COG1858	cytochrome C peroxidase
D3M96_RS04020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3M96_RS04025	COG1959	2 iron, 2 sulfur cluster binding
D3M96_RS04030	COG2346	COG2346, Truncated hemoglobins
D3M96_RS04035	COG0463	Glycosyl transferase, family 2
D3M96_RS04070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3M96_RS04075	COG3383	formate dehydrogenase (NAD+) activity
D3M96_RS04090	COG1910	domain protein
D3M96_RS04095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3M96_RS04105	COG0303	'Molybdopterin
D3M96_RS04110	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3M96_RS04115	COG0314	molybdopterin synthase activity
D3M96_RS04125	COG0315	cyclic pyranopterin monophosphate synthase activity
D3M96_RS04155	COG0678	peroxiredoxin activity
D3M96_RS04165	COG0697	spore germination
D3M96_RS04170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3M96_RS04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3M96_RS04235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3M96_RS04240	COG4535	Mg2 and Co2 transporter CorC
D3M96_RS04245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3M96_RS04250	COG1702	phosphate starvation-inducible protein PhoH
D3M96_RS04255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3M96_RS04270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3M96_RS04275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3M96_RS04280	COG1862	Preprotein translocase
D3M96_RS04285	COG0343	queuine tRNA-ribosyltransferase activity
D3M96_RS04290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3M96_RS04295	COG2027	D-alanyl-D-alanine carboxypeptidase
D3M96_RS04300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3M96_RS04310	COG4575	ribosome binding
D3M96_RS04325	COG0583	DNA-binding transcription factor activity
D3M96_RS04340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3M96_RS04365	COG0477	Major facilitator Superfamily
D3M96_RS04390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3M96_RS04400	COG0436	Aminotransferase
D3M96_RS04410	COG0281	malic enzyme
D3M96_RS04410	COG0280	phosphate acetyltransferase
D3M96_RS04420	COG2732	(Barnase) inhibitor
D3M96_RS04425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3M96_RS04430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3M96_RS04435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3M96_RS04440	COG0126	phosphoglycerate kinase activity
D3M96_RS04465	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3M96_RS04475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3M96_RS04480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3M96_RS04485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3M96_RS04490	COG0009	L-threonylcarbamoyladenylate synthase
D3M96_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS04500	COG2030	dehydratase
D3M96_RS04505	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS04515	COG0405	Gamma-glutamyltransferase
D3M96_RS04525	COG0579	oxidoreductase
D3M96_RS04530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3M96_RS04535	COG0259	pyridoxamine-phosphate oxidase activity
D3M96_RS04545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D3M96_RS04560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3M96_RS04565	COG1215	transferase activity, transferring glycosyl groups
D3M96_RS04575	COG0488	(ABC) transporter
D3M96_RS04595	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3M96_RS04600	COG2894	cell division
D3M96_RS04610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3M96_RS04620	COG1294	oxidase, subunit
D3M96_RS04625	COG0038	chloride channel
D3M96_RS04635	COG0514	ATP-dependent DNA helicase (RecQ)
D3M96_RS04640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3M96_RS04645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3M96_RS04650	COG0633	Ferredoxin
D3M96_RS04655	COG0488	(ABC) transporter
D3M96_RS04665	COG2001	Belongs to the MraZ family
D3M96_RS04670	COG0275	rRNA processing
D3M96_RS04675	COG3116	cell division
D3M96_RS04685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3M96_RS04690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3M96_RS04705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3M96_RS04710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3M96_RS04715	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3M96_RS04720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3M96_RS04735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D3M96_RS04745	COG0741	lytic transglycosylase activity
D3M96_RS04745	COG1196	nuclear chromosome segregation
D3M96_RS04745	COG0739	heme binding
D3M96_RS04750	COG0653	protein targeting
D3M96_RS04760	COG2239	Acts as a magnesium transporter
D3M96_RS04770	COG1473	amidohydrolase
D3M96_RS04775	COG0318	PFAM AMP-dependent synthetase and ligase
D3M96_RS04785	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3M96_RS04785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3M96_RS04800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3M96_RS04805	COG2011	ABC-type metal ion transport system permease component
D3M96_RS04815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS04820	COG0765	amino acid transport
D3M96_RS04825	COG1126	abc transporter atp-binding protein
D3M96_RS04835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3M96_RS04850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS04855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3M96_RS04860	COG0700	Nucleoside recognition
D3M96_RS04875	COG0204	Acyl-transferase
D3M96_RS04880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3M96_RS04885	COG0751	glycine-tRNA ligase activity
D3M96_RS04890	COG0752	glycyl-tRNA synthetase alpha subunit
D3M96_RS04910	COG1309	transcriptional regulator
D3M96_RS04930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3M96_RS04935	COG0617	tRNA 3'-terminal CCA addition
D3M96_RS04945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3M96_RS04950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3M96_RS04955	COG1953	Uracil, thiamine, allantoin
D3M96_RS04960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3M96_RS04965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3M96_RS04970	COG0586	Pfam SNARE associated Golgi protein
D3M96_RS04975	COG1477	protein flavinylation
D3M96_RS04995	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3M96_RS05000	COG0802	atpase or kinase
D3M96_RS05010	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS05015	COG0280	phosphate acetyltransferase
D3M96_RS05015	COG0281	malic enzyme
D3M96_RS05020	COG0583	DNA-binding transcription factor activity
D3M96_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS05030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3M96_RS05050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS05070	COG1733	regulation of RNA biosynthetic process
D3M96_RS05075	COG2910	NAD(P)H-binding
D3M96_RS05085	COG2223	nitrite transmembrane transporter activity
D3M96_RS05095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3M96_RS05100	COG4974	Belongs to the 'phage' integrase family
D3M96_RS05105	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3M96_RS05110	COG4149	molybdate abc transporter
D3M96_RS05115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3M96_RS05130	COG1074	ATP-dependent DNA helicase activity
D3M96_RS05165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3M96_RS05185	COG3391	amine dehydrogenase activity
D3M96_RS05190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3M96_RS05195	COG0505	Belongs to the CarA family
D3M96_RS05200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3M96_RS05220	COG2233	PERMEase
D3M96_RS05225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3M96_RS05230	COG1534	Rna-binding protein
D3M96_RS05235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D3M96_RS05240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3M96_RS05245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3M96_RS05250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3M96_RS05265	COG0248	Ppx GppA phosphatase
D3M96_RS05270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3M96_RS05290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3M96_RS05300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3M96_RS05355	COG1368	sulfuric ester hydrolase activity
D3M96_RS05385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3M96_RS05405	COG3328	transposase activity
D3M96_RS05425	COG3327	negative regulation of DNA-templated transcription, initiation
D3M96_RS05430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3M96_RS05445	COG0009	L-threonylcarbamoyladenylate synthase
D3M96_RS05450	COG1994	Peptidase M50
D3M96_RS05455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3M96_RS05460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D3M96_RS05475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3M96_RS05485	COG0156	8-amino-7-oxononanoate synthase activity
D3M96_RS05490	COG2124	cytochrome p450
D3M96_RS05495	COG3135	benzoate transporter
D3M96_RS05500	COG2850	peptidyl-arginine hydroxylation
D3M96_RS05505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3M96_RS05510	COG0582	viral genome integration into host DNA
D3M96_RS05545	COG0477	Major facilitator Superfamily
D3M96_RS05550	COG2003	Belongs to the UPF0758 family
D3M96_RS05600	COG0811	peptide transport
D3M96_RS05630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS05650	COG0431	NADPH-dependent FMN reductase
D3M96_RS05655	COG0798	PFAM Bile acid sodium symporter
D3M96_RS05660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3M96_RS05665	COG0640	Transcriptional regulator
D3M96_RS05670	COG2003	Belongs to the UPF0758 family
D3M96_RS05675	COG0653	protein targeting
D3M96_RS05695	COG0530	calcium, potassium:sodium antiporter activity
D3M96_RS05710	COG1475	DNA binding
D3M96_RS05780	COG3620	sequence-specific DNA binding
D3M96_RS05800	COG3609	addiction module antidote protein, CC2985 family
D3M96_RS05840	COG4962	Type ii secretion system protein e
D3M96_RS05855	COG3451	type IV secretory pathway VirB4
D3M96_RS05885	COG2948	multi-organism process
D3M96_RS05965	COG3391	amine dehydrogenase activity
D3M96_RS06020	COG1538	Outer membrane efflux protein
D3M96_RS06025	COG0363	glucosamine-6-phosphate deaminase activity
D3M96_RS06030	COG1132	(ABC) transporter
D3M96_RS06050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3M96_RS06060	COG0668	transmembrane transport
D3M96_RS06105	COG0154	amidase activity
D3M96_RS06110	COG2031	fatty acid transporter
D3M96_RS06125	COG0483	inositol monophosphate 1-phosphatase activity
D3M96_RS06130	COG1253	flavin adenine dinucleotide binding
D3M96_RS06135	COG1968	undecaprenyl-diphosphatase activity
D3M96_RS06165	COG0215	cysteine-tRNA ligase activity
D3M96_RS06175	COG0825	malonyl-CoA metabolic process
D3M96_RS06180	COG0037	tRNA processing
D3M96_RS06200	COG0330	HflC and HflK could
D3M96_RS06215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3M96_RS06240	COG4208	sulfate ABC transporter
D3M96_RS06245	COG3842	ATPase activity
D3M96_RS06255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3M96_RS06280	COG1304	FMN binding
D3M96_RS06285	COG0435	Glutathione S-transferase
D3M96_RS06290	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3M96_RS06305	COG2094	Belongs to the DNA glycosylase MPG family
D3M96_RS06310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3M96_RS06315	COG2363	Small membrane protein
D3M96_RS06320	COG0598	Magnesium transport protein CorA
D3M96_RS06325	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS06335	COG0747	negative chemotaxis
D3M96_RS06345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3M96_RS06350	COG4172	Belongs to the ABC transporter superfamily
D3M96_RS06360	COG3284	Transcriptional regulator
D3M96_RS06365	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS06370	COG1454	alcohol dehydrogenase
D3M96_RS06375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3M96_RS06400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3M96_RS06430	COG3829	transcription factor binding
D3M96_RS06435	COG0477	Major facilitator Superfamily
D3M96_RS06445	COG0039	L-malate dehydrogenase activity
D3M96_RS06450	COG2188	Transcriptional regulator
D3M96_RS06455	COG2009	succinate dehydrogenase
D3M96_RS06465	COG1053	succinate dehydrogenase
D3M96_RS06470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3M96_RS06475	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D3M96_RS06480	COG0372	Belongs to the citrate synthase family
D3M96_RS06485	COG2186	Transcriptional regulator
D3M96_RS06490	COG1620	l-lactate permease
D3M96_RS06495	COG0281	malic enzyme
D3M96_RS06495	COG0280	phosphate acetyltransferase
D3M96_RS06500	COG0567	Dehydrogenase, E1 component
D3M96_RS06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3M96_RS06510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3M96_RS06515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3M96_RS06535	COG2183	response to ionizing radiation
D3M96_RS06540	COG1199	ATP-dependent helicase activity
D3M96_RS06545	COG0659	secondary active sulfate transmembrane transporter activity
D3M96_RS06560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS06585	COG0564	pseudouridine synthase activity
D3M96_RS06595	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3M96_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS06605	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D3M96_RS06630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3M96_RS06635	COG1187	pseudouridine synthase activity
D3M96_RS06640	COG0779	Required for maturation of 30S ribosomal subunits
D3M96_RS06645	COG0195	Participates in both transcription termination and antitermination
D3M96_RS06645	COG2251	uridine kinase activity
D3M96_RS06655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3M96_RS06660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3M96_RS06665	COG1217	gtp-binding protein TYPA
D3M96_RS06670	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3M96_RS06680	COG4160	amino acid transport
D3M96_RS06685	COG4215	(ABC) transporter
D3M96_RS06695	COG1611	Belongs to the LOG family
D3M96_RS06705	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3M96_RS06710	COG0501	Belongs to the peptidase M48B family
D3M96_RS06725	COG1722	exodeoxyribonuclease VII activity
D3M96_RS06730	COG0142	geranyltranstransferase activity
D3M96_RS06735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3M96_RS06740	COG1469	GTP cyclohydrolase I activity
D3M96_RS06745	COG0360	Binds together with S18 to 16S ribosomal RNA
D3M96_RS06750	COG2965	DNA replication, synthesis of RNA primer
D3M96_RS06755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3M96_RS06760	COG0359	binds to the 23S rRNA
D3M96_RS06765	COG0305	Participates in initiation and elongation during chromosome replication
D3M96_RS06775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3M96_RS06780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D3M96_RS06785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3M96_RS06795	COG0436	Aminotransferase
D3M96_RS06815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3M96_RS06820	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D3M96_RS06825	COG1562	ergosterol biosynthetic process
D3M96_RS06830	COG1562	ergosterol biosynthetic process
D3M96_RS06835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3M96_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS06865	COG3842	ATPase activity
D3M96_RS06870	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3M96_RS06875	COG1177	transmembrane transport
D3M96_RS06880	COG1393	Belongs to the ArsC family
D3M96_RS06885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D3M96_RS06890	COG0704	Plays a role in the regulation of phosphate uptake
D3M96_RS06895	COG3706	GGDEF domain
D3M96_RS06895	COG4251	negative regulation of phosphorylation
D3M96_RS06895	COG5001	Diguanylate cyclase
D3M96_RS06895	COG2203	Gaf domain
D3M96_RS06900	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D3M96_RS06905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3M96_RS06905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3M96_RS06910	COG1643	Atp-dependent helicase
D3M96_RS06920	COG0438	transferase activity, transferring glycosyl groups
D3M96_RS06925	COG0726	polysaccharide deacetylase
D3M96_RS06940	COG0297	glycogen (starch) synthase activity
D3M96_RS06965	COG1132	(ABC) transporter
D3M96_RS06985	COG3328	transposase activity
D3M96_RS07030	COG2186	Transcriptional regulator
D3M96_RS07035	COG0277	FAD linked oxidase domain protein
D3M96_RS07040	COG0277	FAD linked oxidase domain protein
D3M96_RS07045	COG0247	lactate metabolic process
D3M96_RS07075	COG2159	amidohydrolase
D3M96_RS07090	COG0583	DNA-binding transcription factor activity
D3M96_RS07095	COG0477	Major facilitator Superfamily
D3M96_RS07145	COG0628	permease
D3M96_RS07150	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3M96_RS07165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3M96_RS07175	COG0697	spore germination
D3M96_RS07195	COG3094	Invasion gene expression up-regulator, SirB
D3M96_RS07205	COG0640	Transcriptional regulator
D3M96_RS07230	COG0659	secondary active sulfate transmembrane transporter activity
D3M96_RS07240	COG2314	TM2 domain
D3M96_RS07245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3M96_RS07250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3M96_RS07255	COG1388	LysM domain
D3M96_RS07255	COG0791	NLP P60 protein
D3M96_RS07275	COG1360	Flagellar Motor Protein
D3M96_RS07285	COG0835	chemotaxis
D3M96_RS07290	COG0840	transmembrane signaling receptor activity
D3M96_RS07295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3M96_RS07305	COG0745	RESPONSE REGULATOR receiver
D3M96_RS07310	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D3M96_RS07315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3M96_RS07320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3M96_RS07330	COG3550	peptidyl-serine autophosphorylation
D3M96_RS07345	COG2747	anti-sigma28 factor FlgM
D3M96_RS07355	COG1815	bacterial-type flagellum-dependent cell motility
D3M96_RS07360	COG1558	bacterial-type flagellum-dependent cell motility
D3M96_RS07365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3M96_RS07405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3M96_RS07420	COG0840	transmembrane signaling receptor activity
D3M96_RS07440	COG1987	bacterial-type flagellum assembly
D3M96_RS07455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3M96_RS07480	COG1157	protein secretion by the type III secretion system
D3M96_RS07495	COG1766	The M ring may be actively involved in energy transduction
D3M96_RS07500	COG1677	Flagellar hook-basal body complex protein FliE
D3M96_RS07505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3M96_RS07530	COG1334	flagellar protein FlaG
D3M96_RS07535	COG1191	sigma factor activity
D3M96_RS07590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3M96_RS07610	COG2733	membrane
D3M96_RS07615	COG0840	transmembrane signaling receptor activity
D3M96_RS07620	COG0840	transmembrane signaling receptor activity
D3M96_RS07645	COG2610	gluconate transmembrane transporter activity
D3M96_RS07665	COG4974	Belongs to the 'phage' integrase family
D3M96_RS07695	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS07730	COG2824	Alkylphosphonate utilization operon protein PhnA
D3M96_RS07745	COG4771	TonB-dependent receptor
D3M96_RS07750	COG1858	cytochrome C peroxidase
D3M96_RS07755	COG1454	alcohol dehydrogenase
D3M96_RS07775	COG0668	transmembrane transport
D3M96_RS07780	COG1113	amino acid transport
D3M96_RS07785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3M96_RS07835	COG3846	protein secretion by the type IV secretion system
D3M96_RS07850	COG3451	type IV secretory pathway VirB4
D3M96_RS07860	COG3838	Conjugal transfer protein Trbc
D3M96_RS07865	COG4962	Type ii secretion system protein e
D3M96_RS07885	COG0583	DNA-binding transcription factor activity
D3M96_RS07900	COG0667	Aldo Keto reductase
D3M96_RS07920	COG4959	Type IV secretory pathway protease TraF
D3M96_RS07935	COG1192	Involved in chromosome partitioning
D3M96_RS07965	COG1396	sequence-specific DNA binding
D3M96_RS08005	COG0515	serine threonine protein kinase
D3M96_RS08010	COG2815	serine threonine protein kinase
D3M96_RS08010	COG0515	serine threonine protein kinase
D3M96_RS08015	COG2003	Belongs to the UPF0758 family
D3M96_RS08030	COG4804	nuclease activity
D3M96_RS08065	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3M96_RS08090	COG1278	Cold shock
D3M96_RS08095	COG0642	Histidine kinase
D3M96_RS08105	COG3278	Belongs to the heme-copper respiratory oxidase family
D3M96_RS08115	COG2863	cytochrome
D3M96_RS08120	COG3258	Cytochrome c
D3M96_RS08125	COG3328	transposase activity
D3M96_RS08130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3M96_RS08135	COG4774	siderophore transport
D3M96_RS08170	COG0025	NhaP-type Na H and K H
D3M96_RS08185	COG1289	transmembrane transporter activity
D3M96_RS08190	COG2252	PERMEase
D3M96_RS08210	COG1999	signal sequence binding
D3M96_RS08220	COG0069	glutamate synthase activity
D3M96_RS08230	COG1846	Transcriptional regulator
D3M96_RS08235	COG1058	Belongs to the CinA family
D3M96_RS08235	COG1546	Belongs to the CinA family
D3M96_RS08240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3M96_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS08305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3M96_RS08315	COG1511	domain protein
D3M96_RS08315	COG3264	Mechanosensitive ion channel
D3M96_RS08320	COG1511	domain protein
D3M96_RS08320	COG3264	Mechanosensitive ion channel
D3M96_RS08325	COG0477	Major facilitator Superfamily
D3M96_RS08340	COG1396	sequence-specific DNA binding
D3M96_RS08345	COG3437	response regulator, receiver
D3M96_RS08350	COG2198	Histidine kinase
D3M96_RS08350	COG0784	Response regulator, receiver
D3M96_RS08350	COG2205	protein histidine kinase activity
D3M96_RS08355	COG2239	Acts as a magnesium transporter
D3M96_RS08365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3M96_RS08370	COG1490	D-aminoacyl-tRNA deacylase activity
D3M96_RS08385	COG0456	acetyltransferase
D3M96_RS08390	COG3012	SEC-C Motif Domain Protein
D3M96_RS08395	COG0501	Belongs to the peptidase M48B family
D3M96_RS08465	COG3706	GGDEF domain
D3M96_RS08480	COG1522	sequence-specific DNA binding
D3M96_RS08485	COG0626	cystathionine gamma-synthase activity
D3M96_RS08495	COG0494	nUDIX hydrolase
D3M96_RS08500	COG2832	Protein of unknown function (DUF454)
D3M96_RS08510	COG0137	argininosuccinate synthase activity
D3M96_RS08520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3M96_RS08545	COG1609	Transcriptional regulator
D3M96_RS08550	COG0519	Catalyzes the synthesis of GMP from XMP
D3M96_RS08550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3M96_RS08560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3M96_RS08570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3M96_RS08575	COG2205	protein histidine kinase activity
D3M96_RS08580	COG0745	RESPONSE REGULATOR receiver
D3M96_RS08585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3M96_RS08595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3M96_RS08600	COG0268	Binds directly to 16S ribosomal RNA
D3M96_RS08605	COG0728	peptidoglycan biosynthetic process
D3M96_RS08615	COG0563	adenylate kinase activity
D3M96_RS08620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3M96_RS08625	COG2835	tetraacyldisaccharide 4'-kinase activity
D3M96_RS08630	COG1663	tetraacyldisaccharide 4'-kinase activity
D3M96_RS08635	COG0848	biopolymer transport protein
D3M96_RS08640	COG0811	peptide transport
D3M96_RS08645	COG1570	exodeoxyribonuclease VII activity
D3M96_RS08650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3M96_RS08660	COG0183	Belongs to the thiolase family
D3M96_RS08670	COG1278	Cold shock
D3M96_RS08675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3M96_RS08680	COG0542	response to heat
D3M96_RS08685	COG2995	paraquat-inducible protein a
D3M96_RS08690	COG3008	intermembrane lipid transfer
D3M96_RS08690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3M96_RS08710	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS08760	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D3M96_RS08765	COG0756	dUTP diphosphatase activity
D3M96_RS08775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3M96_RS08780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3M96_RS08785	COG0196	riboflavin kinase activity
D3M96_RS08790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3M96_RS08795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3M96_RS08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3M96_RS08805	COG0210	DNA helicase
D3M96_RS08830	COG0488	(ABC) transporter
D3M96_RS08835	COG2890	protein-(glutamine-N5) methyltransferase activity
D3M96_RS08840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3M96_RS08845	COG2171	N-acyltransferase activity
D3M96_RS08855	COG2207	Transcriptional regulator
D3M96_RS08865	COG0471	metal ion transport
D3M96_RS08865	COG3273	potassium ion transport
D3M96_RS08910	COG0789	Transcriptional regulator
D3M96_RS08925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3M96_RS08930	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3M96_RS08935	COG0740	serine-type endopeptidase activity
D3M96_RS08945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3M96_RS08955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3M96_RS08965	COG0556	nucleotide-excision repair
D3M96_RS08970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3M96_RS08980	COG1104	cysteine desulfurase activity
D3M96_RS08990	COG0316	Belongs to the HesB IscA family
D3M96_RS09005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3M96_RS09010	COG4221	oxidoreductase activity
D3M96_RS09020	COG0840	transmembrane signaling receptor activity
D3M96_RS09025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3M96_RS09030	COG0697	spore germination
D3M96_RS09035	COG0385	Bile acid
D3M96_RS09045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3M96_RS09060	COG1136	(ABC) transporter
D3M96_RS09065	COG0084	hydrolase, TatD family'
D3M96_RS09080	COG0613	PHP domain protein
D3M96_RS09090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3M96_RS09090	COG0047	phosphoribosylformylglycinamidine synthase activity
D3M96_RS09105	COG0519	Catalyzes the synthesis of GMP from XMP
D3M96_RS09105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3M96_RS09120	COG1002	Type II restriction enzyme, methylase subunits
D3M96_RS09130	COG1061	Type III restriction enzyme res subunit
D3M96_RS09135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3M96_RS09155	COG0583	DNA-binding transcription factor activity
D3M96_RS09170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3M96_RS09180	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS09195	COG2378	regulation of single-species biofilm formation
D3M96_RS09200	COG0523	cobalamin synthesis protein
D3M96_RS09205	COG1469	GTP cyclohydrolase I activity
D3M96_RS09210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3M96_RS09220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3M96_RS09225	COG0735	belongs to the Fur family
D3M96_RS09230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3M96_RS09245	COG1942	4-Oxalocrotonate Tautomerase
D3M96_RS09260	COG2070	2-Nitropropane dioxygenase
D3M96_RS09265	COG0583	DNA-binding transcription factor activity
D3M96_RS09290	COG0625	glutathione transferase activity
D3M96_RS09295	COG0583	DNA-binding transcription factor activity
D3M96_RS09315	COG0494	nUDIX hydrolase
D3M96_RS09320	COG0625	glutathione transferase activity
D3M96_RS09325	COG0740	serine-type endopeptidase activity
D3M96_RS09375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3M96_RS09385	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS09405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3M96_RS09410	COG0640	Transcriptional regulator
D3M96_RS09435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3M96_RS09460	COG3485	protocatechuate 3,4-dioxygenase
D3M96_RS09470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D3M96_RS09475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3M96_RS09485	COG3135	benzoate transporter
D3M96_RS09490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3M96_RS09495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D3M96_RS09505	COG4555	ABC transporter
D3M96_RS09515	COG2197	response regulator
D3M96_RS09520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3M96_RS09550	COG1846	Transcriptional regulator
D3M96_RS09555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3M96_RS09560	COG2271	Major facilitator Superfamily
D3M96_RS09570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3M96_RS09580	COG0697	spore germination
D3M96_RS09610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3M96_RS09615	COG0667	Aldo Keto reductase
D3M96_RS09645	COG0456	acetyltransferase
D3M96_RS09650	COG1272	protein, Hemolysin III
D3M96_RS09655	COG3422	double-strand break repair
D3M96_RS09665	COG0477	Major facilitator Superfamily
D3M96_RS09670	COG0154	amidase activity
D3M96_RS09695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS09700	COG0765	amino acid transport
D3M96_RS09705	COG0765	amino acid transport
D3M96_RS09710	COG1126	abc transporter atp-binding protein
D3M96_RS09760	COG2871	sodium ion transport
D3M96_RS09800	COG2814	Major facilitator Superfamily
D3M96_RS09810	COG1280	lysine exporter protein (LysE YggA)
D3M96_RS09820	COG1609	Transcriptional regulator
D3M96_RS09830	COG0402	S-adenosylhomocysteine deaminase activity
D3M96_RS09850	COG0330	HflC and HflK could
D3M96_RS09855	COG1585	Membrane protein implicated in regulation of membrane protease activity
D3M96_RS09860	COG2226	methyltransferase
D3M96_RS09870	COG3042	response to heat
D3M96_RS09880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3M96_RS09890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3M96_RS09895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3M96_RS09910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3M96_RS09915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3M96_RS09950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3M96_RS09955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3M96_RS09960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3M96_RS09965	COG0072	phenylalanine-tRNA ligase activity
D3M96_RS09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3M96_RS09980	COG2833	Protein of unknown function (DUF455)
D3M96_RS09990	COG5265	(ABC) transporter
D3M96_RS09995	COG1959	2 iron, 2 sulfur cluster binding
D3M96_RS10000	COG0719	Fe-S assembly protein
D3M96_RS10005	COG0396	ATPase activity
D3M96_RS10010	COG0719	Fe-S assembly protein
D3M96_RS10020	COG0822	iron-sulfur transferase activity
D3M96_RS10025	COG2151	metal-sulfur cluster biosynthetic enzyme
D3M96_RS10060	COG1215	transferase activity, transferring glycosyl groups
D3M96_RS10065	COG0726	polysaccharide deacetylase
D3M96_RS10065	COG1649	PFAM Uncharacterised BCR, COG1649
D3M96_RS10070	COG0457	Tetratricopeptide repeat
D3M96_RS10085	COG1278	Cold shock
D3M96_RS10100	COG4372	Transposase
D3M96_RS10150	COG0747	negative chemotaxis
D3M96_RS10155	COG0601	transmembrane transport
D3M96_RS10160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3M96_RS10165	COG4172	Belongs to the ABC transporter superfamily
D3M96_RS10175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3M96_RS10235	COG3949	Membrane
D3M96_RS10245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3M96_RS10260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3M96_RS10265	COG0569	domain protein
D3M96_RS10270	COG1902	pentaerythritol trinitrate reductase activity
D3M96_RS10280	COG1610	YqeY-like protein
D3M96_RS10285	COG0587	DNA-directed DNA polymerase activity
D3M96_RS10320	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS10325	COG0583	DNA-binding transcription factor activity
D3M96_RS10330	COG1686	Belongs to the peptidase S11 family
D3M96_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS10360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3M96_RS10365	COG4221	oxidoreductase activity
D3M96_RS10370	COG0307	riboflavin synthase, alpha
D3M96_RS10385	COG1301	dicarboxylic acid transport
D3M96_RS10390	COG4191	Histidine kinase
D3M96_RS10400	COG0583	DNA-binding transcription factor activity
D3M96_RS10405	COG1053	succinate dehydrogenase
D3M96_RS10455	COG2233	PERMEase
D3M96_RS10460	COG0071	Belongs to the small heat shock protein (HSP20) family
D3M96_RS10465	COG1473	amidohydrolase
D3M96_RS10475	COG2814	Major facilitator Superfamily
D3M96_RS10505	COG2816	NAD+ diphosphatase activity
D3M96_RS10510	COG1561	YicC-like family, N-terminal region
D3M96_RS10525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3M96_RS10530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3M96_RS10535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3M96_RS10540	COG0174	glutamine synthetase
D3M96_RS10545	COG2153	protein acetylation
D3M96_RS10555	COG3842	ATPase activity
D3M96_RS10560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3M96_RS10565	COG1840	ABC-type Fe3 transport system, periplasmic component
D3M96_RS10580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3M96_RS10590	COG0783	Belongs to the Dps family
D3M96_RS10600	COG3842	ATPase activity
D3M96_RS10605	COG0395	ABC-type sugar transport system, permease component
D3M96_RS10610	COG1175	transmembrane transport
D3M96_RS10615	COG1653	transport
D3M96_RS10630	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS10655	COG0625	glutathione transferase activity
D3M96_RS10665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3M96_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS10675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3M96_RS10680	COG0114	fumarate hydratase activity
D3M96_RS10685	COG2133	pyrroloquinoline quinone binding
D3M96_RS10690	COG0589	response to stress
D3M96_RS10700	COG2807	transmembrane transport
D3M96_RS10710	COG0583	DNA-binding transcription factor activity
D3M96_RS10740	COG0583	DNA-binding transcription factor activity
D3M96_RS10745	COG4974	Belongs to the 'phage' integrase family
D3M96_RS10755	COG2132	Multicopper oxidase
D3M96_RS10760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3M96_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS10890	COG3038	cytochrome b561
D3M96_RS10900	COG2353	YceI-like domain
D3M96_RS10905	COG1393	Belongs to the ArsC family
D3M96_RS10910	COG0625	glutathione transferase activity
D3M96_RS10935	COG0084	hydrolase, TatD family'
D3M96_RS10940	COG0470	DNA polymerase III
D3M96_RS10950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3M96_RS10955	COG0354	folic acid binding
D3M96_RS10970	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS10975	COG2914	Belongs to the UPF0125 (RnfH) family
D3M96_RS10980	COG2867	negative regulation of translational initiation
D3M96_RS10985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3M96_RS10990	COG1252	NADH dehydrogenase
D3M96_RS11015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3M96_RS11020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3M96_RS11025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3M96_RS11035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3M96_RS11040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3M96_RS11050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3M96_RS11060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3M96_RS11065	COG0575	Belongs to the CDS family
D3M96_RS11070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3M96_RS11075	COG0233	cytoplasmic translational termination
D3M96_RS11080	COG0528	UMP kinase activity
D3M96_RS11085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3M96_RS11090	COG0052	Belongs to the universal ribosomal protein uS2 family
D3M96_RS11095	COG0024	Methionine aminopeptidase
D3M96_RS11100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3M96_RS11125	COG1286	toxin biosynthetic process
D3M96_RS11135	COG0285	dihydrofolate synthase activity
D3M96_RS11140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3M96_RS11145	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3M96_RS11150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3M96_RS11165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3M96_RS11175	COG1999	signal sequence binding
D3M96_RS11180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3M96_RS11190	COG0640	Transcriptional regulator
D3M96_RS11210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3M96_RS11220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3M96_RS11225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3M96_RS11230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D3M96_RS11250	COG0183	Belongs to the thiolase family
D3M96_RS11255	COG0183	Belongs to the thiolase family
D3M96_RS11265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3M96_RS11295	COG0194	GDP metabolic process
D3M96_RS11300	COG1758	RNA polymerase activity
D3M96_RS11305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3M96_RS11315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3M96_RS11320	COG0739	heme binding
D3M96_RS11325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS11330	COG0584	glycerophosphoryl diester phosphodiesterase
D3M96_RS11335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3M96_RS11340	COG1187	pseudouridine synthase activity
D3M96_RS11345	COG3161	chorismate lyase activity
D3M96_RS11350	COG2814	Major facilitator Superfamily
D3M96_RS11355	COG0656	L-ascorbic acid biosynthetic process
D3M96_RS11365	COG0668	transmembrane transport
D3M96_RS11370	COG0165	Argininosuccinate lyase
D3M96_RS11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3M96_RS11395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3M96_RS11405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3M96_RS11410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D3M96_RS11415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3M96_RS11420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3M96_RS11425	COG2252	PERMEase
D3M96_RS11430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3M96_RS11450	COG0488	(ABC) transporter
D3M96_RS11455	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3M96_RS11460	COG0590	tRNA wobble adenosine to inosine editing
D3M96_RS11465	COG1131	(ABC) transporter
D3M96_RS11470	COG0842	Transport permease protein
D3M96_RS11475	COG0840	transmembrane signaling receptor activity
D3M96_RS11480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS11480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3M96_RS11485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3M96_RS11490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3M96_RS11495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3M96_RS11505	COG2022	thiamine diphosphate biosynthetic process
D3M96_RS11525	COG1414	Transcriptional regulator
D3M96_RS11535	COG0730	response to heat
D3M96_RS11545	COG1666	GTP binding
D3M96_RS11550	COG0318	PFAM AMP-dependent synthetase and ligase
D3M96_RS11555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3M96_RS11560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3M96_RS11560	COG0519	Catalyzes the synthesis of GMP from XMP
D3M96_RS11565	COG2207	Transcriptional regulator
D3M96_RS11580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3M96_RS11585	COG0135	phosphoribosylanthranilate isomerase activity
D3M96_RS11590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS11600	COG0101	tRNA pseudouridine synthase activity
D3M96_RS11610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3M96_RS11615	COG0473	3-isopropylmalate dehydrogenase activity
D3M96_RS11630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3M96_RS11640	COG4566	intracellular signal transduction
D3M96_RS11655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3M96_RS11660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D3M96_RS11670	COG1295	ribonuclease BN
D3M96_RS11680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3M96_RS11715	COG4964	Belongs to the GSP D family
D3M96_RS11755	COG3712	iron ion homeostasis
D3M96_RS11760	COG1595	DNA-templated transcription, initiation
D3M96_RS11770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3M96_RS11780	COG2959	enzyme of heme biosynthesis
D3M96_RS11790	COG0181	hydroxymethylbilane synthase activity
D3M96_RS11795	COG0861	Integral membrane protein TerC family
D3M96_RS11800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3M96_RS11805	COG0045	succinate-CoA ligase (ADP-forming) activity
D3M96_RS11815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3M96_RS11820	COG0583	DNA-binding transcription factor activity
D3M96_RS11825	COG2137	regulation of response to DNA damage stimulus
D3M96_RS11845	COG0477	Major facilitator Superfamily
D3M96_RS11860	COG0318	PFAM AMP-dependent synthetase and ligase
D3M96_RS11865	COG1024	Enoyl-CoA hydratase
D3M96_RS11870	COG3162	membrane
D3M96_RS11885	COG0540	Belongs to the ATCase OTCase family
D3M96_RS11900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3M96_RS11915	COG2070	2-Nitropropane dioxygenase
D3M96_RS11920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3M96_RS11925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3M96_RS11925	COG2111	Na H antiporter
D3M96_RS11930	COG1006	Multisubunit Na H antiporter MnhC subunit
D3M96_RS11935	COG0651	ATP synthesis coupled electron transport
D3M96_RS11945	COG2212	antiporter activity
D3M96_RS11960	COG3158	transport of potassium into the cell
D3M96_RS11965	COG0642	Histidine kinase
D3M96_RS11990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3M96_RS11995	COG4208	sulfate ABC transporter
D3M96_RS12000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3M96_RS12005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3M96_RS12025	COG1278	Cold shock
D3M96_RS12055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3M96_RS12055	COG1648	precorrin-2 dehydrogenase activity
D3M96_RS12060	COG2010	Cytochrome c
D3M96_RS12070	COG1522	sequence-specific DNA binding
D3M96_RS12085	COG0535	radical SAM domain protein
D3M96_RS12090	COG1648	precorrin-2 dehydrogenase activity
D3M96_RS12090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3M96_RS12100	COG2010	Cytochrome c
D3M96_RS12105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS12115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3M96_RS12120	COG0557	exoribonuclease II activity
D3M96_RS12135	COG0076	glutamate decarboxylase activity
D3M96_RS12140	COG0531	amino acid
D3M96_RS12170	COG2375	cellular response to nickel ion
D3M96_RS12200	COG0583	DNA-binding transcription factor activity
D3M96_RS12205	COG3842	ATPase activity
D3M96_RS12215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3M96_RS12220	COG1840	ABC-type Fe3 transport system, periplasmic component
D3M96_RS12230	COG1247	-acetyltransferase
D3M96_RS12245	COG3530	Putative quorum-sensing-regulated virulence factor
D3M96_RS12250	COG0625	glutathione transferase activity
D3M96_RS12260	COG1741	Belongs to the pirin family
D3M96_RS12270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3M96_RS12275	COG2814	Major facilitator Superfamily
D3M96_RS12280	COG2807	transmembrane transport
D3M96_RS12285	COG2207	Transcriptional regulator
D3M96_RS12290	COG3135	benzoate transporter
D3M96_RS12315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3M96_RS12325	COG0402	S-adenosylhomocysteine deaminase activity
D3M96_RS12335	COG0745	RESPONSE REGULATOR receiver
D3M96_RS12340	COG2205	protein histidine kinase activity
D3M96_RS12355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3M96_RS12360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3M96_RS12365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3M96_RS12375	COG0330	HflC and HflK could
D3M96_RS12380	COG0330	HflC and HflK could
D3M96_RS12385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3M96_RS12390	COG1923	regulation of RNA biosynthetic process
D3M96_RS12400	COG1160	GTP binding
D3M96_RS12405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3M96_RS12410	COG2976	Protein conserved in bacteria
D3M96_RS12430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3M96_RS12435	COG0105	UTP biosynthetic process
D3M96_RS12445	COG0336	Belongs to the RNA methyltransferase TrmD family
D3M96_RS12455	COG0228	four-way junction DNA binding
D3M96_RS12460	COG0425	Belongs to the sulfur carrier protein TusA family
D3M96_RS12465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3M96_RS12480	COG2351	hydroxyisourate hydrolase activity
D3M96_RS12515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3M96_RS12540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3M96_RS12545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3M96_RS12560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3M96_RS12565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3M96_RS12570	COG0542	response to heat
D3M96_RS12575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3M96_RS12610	COG3278	Belongs to the heme-copper respiratory oxidase family
D3M96_RS12620	COG2217	Heavy metal translocating P-type atpase
D3M96_RS12630	COG2224	Isocitrate lyase
D3M96_RS12635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3M96_RS12635	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3M96_RS12660	COG1472	Belongs to the glycosyl hydrolase 3 family
D3M96_RS12665	COG0736	holo-[acyl-carrier-protein] synthase activity
D3M96_RS12675	COG2050	protein possibly involved in aromatic compounds catabolism
D3M96_RS12680	COG1024	Enoyl-CoA hydratase
D3M96_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS12690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3M96_RS12695	COG2151	metal-sulfur cluster biosynthetic enzyme
D3M96_RS12700	COG3396	Phenylacetate-CoA oxygenase
D3M96_RS12705	COG3460	Phenylacetate-CoA oxygenase
D3M96_RS12710	COG3396	Phenylacetate-CoA oxygenase
D3M96_RS12715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D3M96_RS12720	COG0501	Belongs to the peptidase M48B family
D3M96_RS12725	COG1162	GTPase activity
D3M96_RS12735	COG0335	large ribosomal subunit rRNA binding
D3M96_RS12750	COG0450	alkyl hydroperoxide reductase
D3M96_RS12755	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS12775	COG2951	lytic endotransglycosylase activity
D3M96_RS12790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3M96_RS12795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3M96_RS12800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D3M96_RS12820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3M96_RS12825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D3M96_RS12830	COG0287	Prephenate dehydrogenase
D3M96_RS12840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3M96_RS12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3M96_RS12875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3M96_RS12885	COG4771	TonB-dependent receptor
D3M96_RS12900	COG0753	catalase activity
D3M96_RS12910	COG4335	DNA alkylation repair
D3M96_RS12915	COG1846	Transcriptional regulator
D3M96_RS12920	COG0436	Aminotransferase
D3M96_RS12925	COG1309	transcriptional regulator
D3M96_RS12960	COG0625	glutathione transferase activity
D3M96_RS12970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D3M96_RS12975	COG1280	lysine exporter protein (LysE YggA)
D3M96_RS12995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3M96_RS13005	COG2198	Histidine kinase
D3M96_RS13005	COG2205	protein histidine kinase activity
D3M96_RS13005	COG0784	Response regulator, receiver
D3M96_RS13015	COG2046	Belongs to the sulfate adenylyltransferase family
D3M96_RS13030	COG0583	DNA-binding transcription factor activity
D3M96_RS13035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3M96_RS13050	COG0840	transmembrane signaling receptor activity
D3M96_RS13055	COG2119	membrane
D3M96_RS13070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3M96_RS13080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3M96_RS13095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3M96_RS13100	COG2321	neutral zinc metallopeptidase
D3M96_RS13110	COG0347	Belongs to the P(II) protein family
D3M96_RS13115	COG0004	ammonium transporteR
D3M96_RS13120	COG3909	cytochrome
D3M96_RS13130	COG0625	glutathione transferase activity
D3M96_RS13140	COG0657	acetylesterase activity
D3M96_RS13145	COG0730	response to heat
D3M96_RS13150	COG0482	sulfurtransferase activity
D3M96_RS13155	COG0277	FAD linked oxidase domain protein
D3M96_RS13160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3M96_RS13165	COG2879	small protein
D3M96_RS13170	COG1966	Carbon starvation protein
D3M96_RS13175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS13180	COG0765	amino acid transport
D3M96_RS13185	COG0765	amino acid transport
D3M96_RS13190	COG1126	abc transporter atp-binding protein
D3M96_RS13195	COG0028	Belongs to the TPP enzyme family
D3M96_RS13205	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D3M96_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS13220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3M96_RS13225	COG1116	anion transmembrane transporter activity
D3M96_RS13240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3M96_RS13245	COG1414	Transcriptional regulator
D3M96_RS13255	COG5285	phytanoyl-CoA dioxygenase
D3M96_RS13260	COG0662	Cupin 2, conserved barrel domain protein
D3M96_RS13270	COG0456	acetyltransferase
D3M96_RS13275	COG1846	Transcriptional regulator
D3M96_RS13285	COG0312	modulator of DNA gyrase
D3M96_RS13300	COG0308	aminopeptidase N
D3M96_RS13305	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D3M96_RS13320	COG0473	3-isopropylmalate dehydrogenase activity
D3M96_RS13330	COG0433	COG0433 Predicted ATPase
D3M96_RS13335	COG0217	transcriptional regulatory protein
D3M96_RS13340	COG0151	Belongs to the GarS family
D3M96_RS13350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3M96_RS13355	COG0799	negative regulation of ribosome biogenesis
D3M96_RS13360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3M96_RS13365	COG0424	maF-like protein
D3M96_RS13385	COG0023	Translation Initiation Factor
D3M96_RS13395	COG2084	Dehydrogenase
D3M96_RS13400	COG0625	glutathione transferase activity
D3M96_RS13405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3M96_RS13410	COG1047	Peptidyl-prolyl cis-trans
D3M96_RS13415	COG2003	Belongs to the UPF0758 family
D3M96_RS13430	COG0534	Mate efflux family protein
D3M96_RS13435	COG4175	Glycine betaine
D3M96_RS13440	COG4176	ABC-type proline glycine betaine transport system permease component
D3M96_RS13450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3M96_RS13455	COG2814	Major facilitator Superfamily
D3M96_RS13460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3M96_RS13465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3M96_RS13470	COG0495	leucyl-tRNA aminoacylation
D3M96_RS13485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3M96_RS13490	COG1981	membrane
D3M96_RS13505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3M96_RS13515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3M96_RS13520	COG0148	phosphopyruvate hydratase activity
D3M96_RS13530	COG2814	Major facilitator Superfamily
D3M96_RS13545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D3M96_RS13550	COG0504	CTP synthase activity
D3M96_RS13585	COG0697	spore germination
D3M96_RS13590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3M96_RS13600	COG0791	NLP P60 protein
D3M96_RS13610	COG0583	DNA-binding transcription factor activity
D3M96_RS13620	COG0583	DNA-binding transcription factor activity
D3M96_RS13625	COG4774	siderophore transport
D3M96_RS13635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3M96_RS13640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3M96_RS13650	COG1309	transcriptional regulator
D3M96_RS13660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3M96_RS13680	COG1045	serine acetyltransferase
D3M96_RS13695	COG1381	Involved in DNA repair and RecF pathway recombination
D3M96_RS13700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3M96_RS13705	COG0571	ribonuclease III activity
D3M96_RS13720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3M96_RS13745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3M96_RS13750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3M96_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS13760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3M96_RS13765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3M96_RS13775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3M96_RS13780	COG1399	metal-binding, possibly nucleic acid-binding protein
D3M96_RS13785	COG0424	maF-like protein
D3M96_RS13795	COG3023	N-Acetylmuramoyl-L-alanine amidase
D3M96_RS13800	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3M96_RS13805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3M96_RS13810	COG0546	phosphoglycolate phosphatase activity
D3M96_RS13815	COG0564	pseudouridine synthase activity
D3M96_RS13820	COG1530	ribonuclease E activity
D3M96_RS13825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3M96_RS13830	COG0159	tryptophan synthase activity
D3M96_RS13835	COG0133	tryptophan synthase activity
D3M96_RS13840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3M96_RS13850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D3M96_RS13855	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3M96_RS13865	COG2878	Part of a membrane complex involved in electron transport
D3M96_RS13870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3M96_RS13875	COG1129	ABC transporter
D3M96_RS13880	COG3047	cAMP biosynthetic process
D3M96_RS13905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3M96_RS13910	COG2917	probably involved in intracellular septation
D3M96_RS13920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3M96_RS13925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3M96_RS13935	COG1196	nuclear chromosome segregation
D3M96_RS13940	COG0477	Major facilitator Superfamily
D3M96_RS13945	COG1573	uracil-dna glycosylase
D3M96_RS13950	COG1214	PFAM Peptidase M22, glycoprotease
D3M96_RS13965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3M96_RS13975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3M96_RS13980	COG0560	Phosphoserine phosphatase
D3M96_RS13995	COG1007	ATP synthesis coupled electron transport
D3M96_RS14010	COG0713	ATP synthesis coupled electron transport
D3M96_RS14020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3M96_RS14025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3M96_RS14030	COG1034	ATP synthesis coupled electron transport
D3M96_RS14045	COG0649	NAD binding
D3M96_RS14050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3M96_RS14055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3M96_RS14060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3M96_RS14070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3M96_RS14085	COG0149	triose-phosphate isomerase activity
D3M96_RS14090	COG0604	alcohol dehydrogenase
D3M96_RS14105	COG1185	polyribonucleotide nucleotidyltransferase activity
D3M96_RS14110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3M96_RS14115	COG1183	phosphatidylcholine synthase activity
D3M96_RS14120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3M96_RS14125	COG0440	acetolactate synthase activity
D3M96_RS14130	COG0028	Belongs to the TPP enzyme family
D3M96_RS14135	COG1289	transmembrane transporter activity
D3M96_RS14140	COG3022	response to hydroperoxide
D3M96_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS14185	COG0582	viral genome integration into host DNA
D3M96_RS14205	COG3299	homolog of phage Mu protein gp47
D3M96_RS14250	COG4386	tail sheath protein
D3M96_RS14290	COG0616	signal peptide processing
D3M96_RS14300	COG1802	Transcriptional regulator
D3M96_RS14300	COG4626	Terminase
D3M96_RS14325	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D3M96_RS14465	COG0582	viral genome integration into host DNA
D3M96_RS14490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3M96_RS14495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3M96_RS14500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D3M96_RS14505	COG1674	ftsk spoiiie
D3M96_RS14510	COG0492	ferredoxin-NADP+ reductase activity
D3M96_RS14530	COG0477	Major facilitator Superfamily
D3M96_RS14550	COG2272	Belongs to the type-B carboxylesterase lipase family
D3M96_RS14555	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS14580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3M96_RS14605	COG0612	Peptidase, M16
D3M96_RS14610	COG0484	heat shock protein binding
D3M96_RS14615	COG0443	Heat shock 70 kDa protein
D3M96_RS14620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3M96_RS14625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3M96_RS14630	COG1420	regulation of RNA biosynthetic process
D3M96_RS14640	COG0497	DNA recombination
D3M96_RS14645	COG0735	belongs to the Fur family
D3M96_RS14650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3M96_RS14665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3M96_RS14685	COG3300	MHYT domain
D3M96_RS14685	COG5001	Diguanylate cyclase
D3M96_RS14700	COG2814	Major facilitator Superfamily
D3M96_RS14715	COG2819	hydrolase of the alpha beta superfamily
D3M96_RS14730	COG0506	proline dehydrogenase activity
D3M96_RS14730	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3M96_RS14730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3M96_RS14745	COG2423	ornithine cyclodeaminase activity
D3M96_RS14750	COG0477	Major facilitator Superfamily
D3M96_RS14755	COG0513	Belongs to the DEAD box helicase family
D3M96_RS14760	COG3657	addiction module killer protein
D3M96_RS14765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3M96_RS14770	COG0583	DNA-binding transcription factor activity
D3M96_RS14775	COG4638	Rieske (2fe-2S)
D3M96_RS14795	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3M96_RS14815	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D3M96_RS14820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3M96_RS14825	COG2814	Major facilitator Superfamily
D3M96_RS14830	COG0166	Belongs to the GPI family
D3M96_RS14850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS14855	COG2814	Major facilitator Superfamily
D3M96_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS14895	COG0842	Transport permease protein
D3M96_RS14900	COG1129	ABC transporter
D3M96_RS14900	COG0842	Transport permease protein
D3M96_RS14905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3M96_RS14910	COG1538	Outer membrane efflux protein
D3M96_RS14915	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3M96_RS14920	COG1309	transcriptional regulator
D3M96_RS14925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D3M96_RS14930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3M96_RS14935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3M96_RS14950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3M96_RS14965	COG0505	Belongs to the CarA family
D3M96_RS14970	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3M96_RS14980	COG0789	Transcriptional regulator
D3M96_RS14995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3M96_RS15040	COG3278	Belongs to the heme-copper respiratory oxidase family
D3M96_RS15045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS15065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3M96_RS15165	COG0517	IMP dehydrogenase activity
D3M96_RS15165	COG0516	GMP reductase activity
D3M96_RS15180	COG1027	Aspartate ammonia-lyase
D3M96_RS15185	COG1846	Transcriptional regulator
D3M96_RS15195	COG0494	nUDIX hydrolase
D3M96_RS15200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3M96_RS15205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3M96_RS15220	COG1414	Transcriptional regulator
D3M96_RS15240	COG0513	Belongs to the DEAD box helicase family
D3M96_RS15260	COG0429	hydrolase of the alpha beta-hydrolase fold
D3M96_RS15285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3M96_RS15295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D3M96_RS15305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3M96_RS15310	COG0632	four-way junction helicase activity
D3M96_RS15320	COG2255	four-way junction helicase activity
D3M96_RS15330	COG0418	dihydroorotase activity
D3M96_RS15340	COG0415	Belongs to the DNA photolyase family
D3M96_RS15360	COG4372	Transposase
D3M96_RS15370	COG3328	transposase activity
D3M96_RS15445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3M96_RS15490	COG1177	transmembrane transport
D3M96_RS15495	COG3842	ATPase activity
D3M96_RS15500	COG1840	ABC-type Fe3 transport system, periplasmic component
D3M96_RS15505	COG2084	Dehydrogenase
D3M96_RS15520	COG0494	nUDIX hydrolase
D3M96_RS15525	COG0442	prolyl-tRNA aminoacylation
D3M96_RS15530	COG0824	Thioesterase
D3M96_RS15535	COG0811	peptide transport
D3M96_RS15550	COG0823	Involved in the tonB-independent uptake of proteins
D3M96_RS15590	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS15595	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3M96_RS15600	COG3845	ABC transporter
D3M96_RS15620	COG0427	acetyl-CoA hydrolase
D3M96_RS15625	COG0583	DNA-binding transcription factor activity
D3M96_RS15650	COG3634	alkyl hydroperoxide reductase activity
D3M96_RS15665	COG0697	spore germination
D3M96_RS15670	COG0175	sulfate reduction
D3M96_RS15680	COG2895	sulfate adenylyltransferase (ATP) activity
D3M96_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
D3M96_RS15695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3M96_RS15700	COG5383	Protein conserved in bacteria
D3M96_RS15710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3M96_RS15725	COG0583	DNA-binding transcription factor activity
D3M96_RS15730	COG1741	Belongs to the pirin family
D3M96_RS15735	COG3706	GGDEF domain
D3M96_RS15740	COG0154	amidase activity
D3M96_RS15750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3M96_RS15765	COG0284	orotidine-5'-phosphate decarboxylase activity
D3M96_RS15785	COG1414	Transcriptional regulator
D3M96_RS15790	COG1546	Belongs to the CinA family
D3M96_RS15795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3M96_RS15805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3M96_RS15810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3M96_RS15835	COG0742	ribosomal rna small subunit methyltransferase
D3M96_RS15840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3M96_RS15845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3M96_RS15875	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D3M96_RS15890	COG1335	isochorismatase
D3M96_RS15895	COG2309	aminopeptidase activity
D3M96_RS15900	COG0596	Alpha beta hydrolase
D3M96_RS15905	COG2010	Cytochrome c
D3M96_RS15905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3M96_RS15910	COG2080	2 iron, 2 sulfur cluster binding
D3M96_RS15915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3M96_RS15915	COG2010	Cytochrome c
D3M96_RS15925	COG0410	ABC transporter
D3M96_RS15930	COG0411	ABC transporter
D3M96_RS15940	COG0683	leucine binding
D3M96_RS15950	COG3706	GGDEF domain
D3M96_RS15965	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS15970	COG3328	transposase activity
D3M96_RS15980	COG1234	tRNA 3'-trailer cleavage
D3M96_RS15985	COG2188	Transcriptional regulator
D3M96_RS15995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3M96_RS16010	COG3608	succinylglutamate desuccinylase aspartoacylase
D3M96_RS16010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3M96_RS16015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3M96_RS16040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3M96_RS16070	COG1335	isochorismatase
D3M96_RS16075	COG2309	aminopeptidase activity
D3M96_RS16080	COG0596	Alpha beta hydrolase
D3M96_RS16095	COG1120	ATPase activity
D3M96_RS16100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3M96_RS16115	COG2031	fatty acid transporter
D3M96_RS16135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3M96_RS16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3M96_RS16145	COG0328	RNA-DNA hybrid ribonuclease activity
D3M96_RS16150	COG2226	methyltransferase
D3M96_RS16155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3M96_RS16160	COG1388	LysM domain
D3M96_RS16160	COG0741	lytic transglycosylase activity
D3M96_RS16170	COG2204	response regulator
D3M96_RS16175	COG4191	Histidine kinase
D3M96_RS16180	COG1301	dicarboxylic acid transport
D3M96_RS16190	COG1054	Belongs to the UPF0176 family
D3M96_RS16210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3M96_RS16235	COG0604	alcohol dehydrogenase
D3M96_RS16245	COG1024	Enoyl-CoA hydratase
D3M96_RS16265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D3M96_RS16315	COG1393	Belongs to the ArsC family
D3M96_RS16320	COG0431	NADPH-dependent FMN reductase
D3M96_RS16325	COG0745	RESPONSE REGULATOR receiver
D3M96_RS16330	COG0642	Histidine kinase
D3M96_RS16415	COG2948	multi-organism process
D3M96_RS16450	COG0433	COG0433 Predicted ATPase
D3M96_RS16515	COG4974	Belongs to the 'phage' integrase family
D3M96_RS16520	COG3344	reverse transcriptase
D3M96_RS16560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3M96_RS16565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3M96_RS16585	COG0582	viral genome integration into host DNA
D3M96_RS16595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3M96_RS16595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3M96_RS16600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3M96_RS16605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3M96_RS16610	COG1881	PFAM PEBP family protein
D3M96_RS16615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3M96_RS16620	COG0739	heme binding
D3M96_RS16625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3M96_RS16630	COG0316	Belongs to the HesB IscA family
D3M96_RS16640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3M96_RS16645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3M96_RS16650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3M96_RS16655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3M96_RS16660	COG0312	modulator of DNA gyrase
D3M96_RS16665	COG3028	Belongs to the UPF0307 family
D3M96_RS16695	COG2205	protein histidine kinase activity
D3M96_RS16695	COG4191	Histidine kinase
D3M96_RS16695	COG0745	RESPONSE REGULATOR receiver
D3M96_RS16715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3M96_RS16745	COG0762	integral membrane protein
D3M96_RS16750	COG2169	Transcriptional regulator
D3M96_RS16750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3M96_RS16755	COG3133	Outer membrane lipoprotein
D3M96_RS16760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3M96_RS16775	COG0439	Biotin carboxylase
D3M96_RS16780	COG0511	ligase activity, forming carbon-carbon bonds
D3M96_RS16785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3M96_RS16790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3M96_RS16795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3M96_RS16800	COG3150	esterase
D3M96_RS16815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3M96_RS16820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3M96_RS16830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3M96_RS16845	COG1678	Uncharacterized ACR, COG1678
D3M96_RS16860	COG0352	thiamine-phosphate diphosphorylase activity
D3M96_RS16865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3M96_RS16880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3M96_RS16890	COG3237	CsbD-like
D3M96_RS16895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3M96_RS16900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3M96_RS16905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3M96_RS16910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3M96_RS16935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3M96_RS16940	COG3328	transposase activity
D3M96_RS16960	COG1126	abc transporter atp-binding protein
D3M96_RS16965	COG0765	amino acid transport
D3M96_RS16970	COG4597	amino acid ABC transporter
D3M96_RS16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3M96_RS16980	COG2884	Cell division ATP-binding protein ftsE
D3M96_RS16985	COG2177	Part of the ABC transporter FtsEX involved in
D3M96_RS16995	COG0772	Belongs to the SEDS family
D3M96_RS17000	COG0768	penicillin binding
D3M96_RS17010	COG1792	Involved in formation and maintenance of cell shape
D3M96_RS17015	COG1077	Cell shape determining protein MreB Mrl
D3M96_RS17020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3M96_RS17025	COG0154	amidase activity
D3M96_RS17030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3M96_RS17035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3M96_RS17040	COG0583	DNA-binding transcription factor activity
D3M96_RS17045	COG2259	Doxx family
D3M96_RS17050	COG3384	dioxygenase
D3M96_RS17070	COG1846	Transcriptional regulator
D3M96_RS17075	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS17080	COG2814	Major facilitator Superfamily
D3M96_RS17090	COG1024	Enoyl-CoA hydratase
D3M96_RS17100	COG3604	Transcriptional regulator
D3M96_RS17120	COG1309	transcriptional regulator
D3M96_RS17135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3M96_RS17160	COG1090	epimerase
D3M96_RS17165	COG0786	glutamate:sodium symporter activity
D3M96_RS17170	COG0142	geranyltranstransferase activity
D3M96_RS17180	COG0494	nUDIX hydrolase
D3M96_RS17185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3M96_RS17210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D3M96_RS17215	COG0237	dephospho-CoA kinase activity
D3M96_RS17225	COG2197	response regulator
D3M96_RS17230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3M96_RS17235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3M96_RS17245	COG0477	Major facilitator Superfamily
D3M96_RS17275	COG4206	TonB-dependent receptor
D3M96_RS17280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3M96_RS17295	COG1595	DNA-templated transcription, initiation
D3M96_RS17310	COG2022	thiamine diphosphate biosynthetic process
D3M96_RS17315	COG0351	phosphomethylpyrimidine kinase
D3M96_RS17320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3M96_RS17325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3M96_RS17330	COG1538	Outer membrane efflux protein
D3M96_RS17335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3M96_RS17345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3M96_RS17360	COG2226	methyltransferase
D3M96_RS17365	COG0745	RESPONSE REGULATOR receiver
D3M96_RS17370	COG5002	protein histidine kinase activity
D3M96_RS17380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3M96_RS17385	COG1984	allophanate hydrolase subunit 2
D3M96_RS17390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3M96_RS17395	COG1238	metal cluster binding
D3M96_RS17425	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D3M96_RS17430	COG4988	ABC transporter
D3M96_RS17440	COG1294	oxidase, subunit
D3M96_RS17445	COG1271	oxidase subunit
D3M96_RS17460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D3M96_RS17475	COG1137	ATPase activity
D3M96_RS17485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3M96_RS17490	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D3M96_RS17495	COG1660	Displays ATPase and GTPase activities
D3M96_RS17505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3M96_RS17510	COG0792	nuclease activity
D3M96_RS17515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3M96_RS17530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3M96_RS17540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3M96_RS17545	COG0793	Belongs to the peptidase S41A family
D3M96_RS17550	COG4942	peptidase
D3M96_RS17555	COG0588	phosphoglycerate mutase activity
D3M96_RS17560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3M96_RS17570	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3M96_RS17575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3M96_RS17580	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS17585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3M96_RS17590	COG1040	competence protein
D3M96_RS17595	COG2226	methyltransferase
D3M96_RS17605	COG2204	response regulator
D3M96_RS17625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3M96_RS17635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3M96_RS17640	COG3473	Maleate cis-trans isomerase
D3M96_RS17660	COG3971	2-oxopent-4-enoate hydratase activity
D3M96_RS17670	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3M96_RS17700	COG1086	Polysaccharide biosynthesis protein
D3M96_RS17725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3M96_RS17740	COG3307	-O-antigen
D3M96_RS17755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3M96_RS17765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3M96_RS17775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3M96_RS17780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3M96_RS17785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3M96_RS17800	COG0356	it plays a direct role in the translocation of protons across the membrane
D3M96_RS17810	COG1024	Enoyl-CoA hydratase
D3M96_RS17825	COG0037	tRNA processing
D3M96_RS17830	COG0163	prenyltransferase activity
D3M96_RS17835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3M96_RS17840	COG2890	protein-(glutamine-N5) methyltransferase activity
D3M96_RS17860	COG0582	viral genome integration into host DNA
D3M96_RS17890	COG0582	viral genome integration into host DNA
D3M96_RS17900	COG0210	DNA helicase
D3M96_RS17940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3M96_RS17945	COG2264	protein methyltransferase activity
D3M96_RS17960	COG3180	Ammonia monooxygenase
D3M96_RS17980	COG5002	protein histidine kinase activity
D3M96_RS17995	COG0477	Major facilitator Superfamily
D3M96_RS18000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3M96_RS18020	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3M96_RS18045	COG0243	molybdopterin cofactor binding
D3M96_RS18045	COG3383	formate dehydrogenase (NAD+) activity
D3M96_RS18050	COG3383	formate dehydrogenase (NAD+) activity
D3M96_RS18050	COG0243	molybdopterin cofactor binding
D3M96_RS18055	COG0437	4 iron, 4 sulfur cluster binding
D3M96_RS18060	COG2864	formate dehydrogenase
D3M96_RS18070	COG1921	L-seryl-tRNASec selenium transferase activity
D3M96_RS18075	COG3276	selenocysteine insertion sequence binding
D3M96_RS18085	COG1476	TRANSCRIPTIONal
D3M96_RS18090	COG0235	Class ii aldolase
D3M96_RS18100	COG3181	Tripartite tricarboxylate transporter family receptor
D3M96_RS18115	COG0709	Synthesizes selenophosphate from selenide and ATP
D3M96_RS18120	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D3M96_RS18125	COG0348	domain, Protein
D3M96_RS18125	COG3901	Regulator of nitric oxide reductase transcription
D3M96_RS18130	COG4263	nitrous-oxide reductase activity
D3M96_RS18145	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3M96_RS18160	COG0166	Belongs to the GPI family
D3M96_RS18190	COG2233	PERMEase
D3M96_RS18195	COG0697	spore germination
D3M96_RS18200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS18205	COG0697	spore germination
D3M96_RS18230	COG2885	chlorophyll binding
D3M96_RS18325	COG0183	Belongs to the thiolase family
D3M96_RS18330	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3M96_RS18330	COG1024	Enoyl-CoA hydratase
D3M96_RS18345	COG1127	ABC transporter
D3M96_RS18350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3M96_RS18355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3M96_RS18370	COG1131	(ABC) transporter
D3M96_RS18375	COG0842	Transport permease protein
D3M96_RS18385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3M96_RS18395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3M96_RS18400	COG0131	Imidazoleglycerol-phosphate dehydratase
D3M96_RS18410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3M96_RS18415	COG0107	imidazoleglycerol-phosphate synthase activity
D3M96_RS18425	COG0140	phosphoribosyl-ATP diphosphatase activity
D3M96_RS18430	COG0537	adenosine 5'-monophosphoramidase activity
D3M96_RS18435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3M96_RS18440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3M96_RS18450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3M96_RS18460	COG1970	mechanosensitive ion channel activity
D3M96_RS18465	COG0723	plastoquinol--plastocyanin reductase activity
D3M96_RS18470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3M96_RS18475	COG2857	Cytochrome c1
D3M96_RS18480	COG0625	glutathione transferase activity
D3M96_RS18485	COG2969	positive regulation of protein catabolic process
D3M96_RS18490	COG4208	sulfate ABC transporter
D3M96_RS18495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3M96_RS18500	COG4150	thiosulfate binding
D3M96_RS18520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3M96_RS18540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3M96_RS18545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3M96_RS18550	COG3622	Belongs to the hyi family
D3M96_RS18560	COG0129	dihydroxy-acid dehydratase activity
D3M96_RS18565	COG1802	Transcriptional regulator
D3M96_RS18570	COG1522	sequence-specific DNA binding
D3M96_RS18575	COG3483	tryptophan 2,3-dioxygenase activity
D3M96_RS18595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3M96_RS18600	COG0656	L-ascorbic acid biosynthetic process
D3M96_RS18610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3M96_RS18615	COG3706	GGDEF domain
D3M96_RS18620	COG2226	methyltransferase
D3M96_RS18630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3M96_RS18645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D3M96_RS18650	COG0583	DNA-binding transcription factor activity
D3M96_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
D3M96_RS18660	COG1335	isochorismatase
D3M96_RS18680	COG2823	Periplasmic or secreted lipoprotein
D3M96_RS18690	COG3284	Transcriptional regulator
D3M96_RS18695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3M96_RS18715	COG4172	Belongs to the ABC transporter superfamily
D3M96_RS18725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3M96_RS18765	COG3712	iron ion homeostasis
D3M96_RS18770	COG1595	DNA-templated transcription, initiation
D3M96_RS18785	COG1522	sequence-specific DNA binding
D3M96_RS18795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3M96_RS18815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3M96_RS18850	COG0109	protoheme IX farnesyltransferase activity
D3M96_RS18855	COG4753	response regulator
D3M96_RS18855	COG2207	Transcriptional regulator
D3M96_RS18900	COG3568	Endonuclease Exonuclease Phosphatase
D3M96_RS18905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3M96_RS18930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3M96_RS18940	COG1228	amidohydrolase
D3M96_RS18960	COG2986	histidine ammonia-lyase
D3M96_RS18965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3M96_RS18990	COG0789	Transcriptional regulator
D3M96_RS19010	COG0625	glutathione transferase activity
D3M96_RS19040	COG2365	Tyrosine phosphatase family
D3M96_RS19045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3M96_RS19065	COG2423	ornithine cyclodeaminase activity
D3M96_RS19115	COG3069	C4-dicarboxylate transmembrane transporter activity
D3M96_RS19125	COG1802	Transcriptional regulator
D3M96_RS19130	COG1309	transcriptional regulator
D3M96_RS19135	COG2814	Major facilitator Superfamily
D3M96_RS19150	COG2814	Major facilitator Superfamily
D3M96_RS19155	COG3344	reverse transcriptase
D3M96_RS19165	COG2814	Major facilitator Superfamily
D3M96_RS19175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3M96_RS19180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3M96_RS19185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3M96_RS19205	COG5001	Diguanylate cyclase
D3M96_RS19205	COG5002	protein histidine kinase activity
D3M96_RS19210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3M96_RS19215	COG1333	cytochrome c biogenesis protein
D3M96_RS19225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3M96_RS19235	COG4232	protein-disulfide reductase activity
D3M96_RS19255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3M96_RS19260	COG0203	ribosomal protein L17
D3M96_RS19265	COG0202	RNA polymerase activity
D3M96_RS19270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3M96_RS19275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3M96_RS19280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3M96_RS19285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3M96_RS19295	COG0201	protein transport
D3M96_RS19300	COG0200	Binds to the 23S rRNA
D3M96_RS19305	COG1841	ribosomal large subunit assembly
D3M96_RS19310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3M96_RS19315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D3M96_RS19320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3M96_RS19325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3M96_RS19330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3M96_RS19335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3M96_RS19340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3M96_RS19345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3M96_RS19400	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS19405	COG0183	Belongs to the thiolase family
D3M96_RS19430	COG0318	PFAM AMP-dependent synthetase and ligase
D3M96_RS19435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3M96_RS19440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3M96_RS19445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3M96_RS19445	COG1648	precorrin-2 dehydrogenase activity
D3M96_RS19460	COG1960	acyl-CoA dehydrogenase activity
D3M96_RS19475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3M96_RS19480	COG0255	Belongs to the universal ribosomal protein uL29 family
D3M96_RS19485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3M96_RS19490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3M96_RS19495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3M96_RS19500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3M96_RS19505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3M96_RS19510	COG0089	rRNA binding
D3M96_RS19515	COG0088	Forms part of the polypeptide exit tunnel
D3M96_RS19520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3M96_RS19525	COG4175	Glycine betaine
D3M96_RS19530	COG4176	ABC-type proline glycine betaine transport system permease component
D3M96_RS19535	COG0051	transcription antitermination factor activity, RNA binding
D3M96_RS19540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3M96_RS19545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3M96_RS19550	COG0049	tRNA binding
D3M96_RS19555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D3M96_RS19570	COG2205	protein histidine kinase activity
D3M96_RS19585	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D3M96_RS19590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3M96_RS19595	COG0085	RNA polymerase activity
D3M96_RS19600	COG0222	ribosome binding
D3M96_RS19605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3M96_RS19610	COG0081	regulation of translation
D3M96_RS19635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3M96_RS19655	COG1475	DNA binding
D3M96_RS19660	COG1192	Involved in chromosome partitioning
D3M96_RS19665	COG0357	Ribosomal RNA small subunit methyltransferase G
D3M96_RS19670	COG0445	tRNA wobble uridine modification
D3M96_RS19675	COG0436	Aminotransferase
D3M96_RS19685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3M96_RS19690	COG3706	GGDEF domain
D3M96_RS19695	COG0688	phosphatidylethanolamine metabolic process
D3M96_RS19705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3M96_RS19750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3M96_RS19795	COG0753	catalase activity
D3M96_RS19800	COG0706	membrane insertase activity
D3M96_RS19805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3M96_RS19810	COG0594	ribonuclease P activity
D3M96_RS19815	COG0230	Belongs to the bacterial ribosomal protein bL34 family