locus-tag	class	description
CPY64_RS00010	COG4336	lyase activity
CPY64_RS00015	COG0583	DNA-binding transcription factor activity
CPY64_RS00020	COG0859	PFAM glycosyl transferase family 9
CPY64_RS00030	COG1278	Cold shock
CPY64_RS00035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPY64_RS00040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CPY64_RS00045	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CPY64_RS00045	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CPY64_RS00055	COG1686	Belongs to the peptidase S11 family
CPY64_RS00065	COG2921	Belongs to the UPF0250 family
CPY64_RS00070	COG0321	lipoyl(octanoyl) transferase activity
CPY64_RS00075	COG1024	Enoyl-CoA hydratase
CPY64_RS00080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CPY64_RS00090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPY64_RS00135	COG0826	peptidase U32
CPY64_RS00145	COG3154	lipid carrier protein
CPY64_RS00170	COG0134	indole-3-glycerol-phosphate synthase activity
CPY64_RS00175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CPY64_RS00180	COG0512	Glutamine amidotransferase of anthranilate synthase
CPY64_RS00190	COG0546	phosphoglycolate phosphatase activity
CPY64_RS00200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPY64_RS00205	COG2967	ApaG domain
CPY64_RS00210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CPY64_RS00215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPY64_RS00220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPY64_RS00230	COG0840	transmembrane signaling receptor activity
CPY64_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS00245	COG3433	isochorismatase activity
CPY64_RS00245	COG1535	isochorismatase
CPY64_RS00250	COG1169	isochorismate synthase
CPY64_RS00265	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CPY64_RS00265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CPY64_RS00270	COG3433	isochorismatase activity
CPY64_RS00270	COG1535	isochorismatase
CPY64_RS00275	COG1021	2,3-dihydroxybenzoate-AMP ligase
CPY64_RS00305	COG0683	leucine binding
CPY64_RS00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS00355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPY64_RS00360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPY64_RS00365	COG2819	hydrolase of the alpha beta superfamily
CPY64_RS00370	COG0513	Belongs to the DEAD box helicase family
CPY64_RS00375	COG2814	Major facilitator Superfamily
CPY64_RS00385	COG0583	DNA-binding transcription factor activity
CPY64_RS00395	COG1253	flavin adenine dinucleotide binding
CPY64_RS00430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPY64_RS00450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CPY64_RS00470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS00475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CPY64_RS00485	COG0583	DNA-binding transcription factor activity
CPY64_RS00490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS00500	COG0765	amino acid transport
CPY64_RS00505	COG0765	amino acid transport
CPY64_RS00510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPY64_RS00525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPY64_RS00540	COG3391	amine dehydrogenase activity
CPY64_RS00550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CPY64_RS00575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CPY64_RS00580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPY64_RS00585	COG0210	DNA helicase
CPY64_RS00600	COG0070	glutamate synthase
CPY64_RS00600	COG0069	glutamate synthase activity
CPY64_RS00600	COG0067	glutamate synthase
CPY64_RS00605	COG1024	Enoyl-CoA hydratase
CPY64_RS00615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS00620	COG1250	3-hydroxyacyl-CoA dehydrogenase
CPY64_RS00650	COG2918	glutathione biosynthetic process
CPY64_RS00660	COG2197	response regulator
CPY64_RS00665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPY64_RS00675	COG2223	nitrite transmembrane transporter activity
CPY64_RS00680	COG2860	membrane
CPY64_RS00685	COG1346	cytolysis
CPY64_RS00700	COG0251	oxidation-reduction process
CPY64_RS00715	COG5295	Hep Hag repeat protein
CPY64_RS00735	COG1280	lysine exporter protein (LysE YggA)
CPY64_RS00745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPY64_RS00760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPY64_RS00775	COG2096	Adenosyltransferase
CPY64_RS00790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CPY64_RS00795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CPY64_RS00805	COG0523	cobalamin synthesis protein
CPY64_RS00810	COG0735	belongs to the Fur family
CPY64_RS00820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPY64_RS00825	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPY64_RS00830	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CPY64_RS00840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPY64_RS00845	COG1560	Kdo2-lipid A biosynthetic process
CPY64_RS00855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPY64_RS00860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CPY64_RS00865	COG1950	PFAM Membrane protein of
CPY64_RS00900	COG0275	rRNA processing
CPY64_RS00905	COG0730	response to heat
CPY64_RS00910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CPY64_RS00915	COG0129	dihydroxy-acid dehydratase activity
CPY64_RS00920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPY64_RS00940	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS00950	COG0628	permease
CPY64_RS00965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS01005	COG1021	2,3-dihydroxybenzoate-AMP ligase
CPY64_RS01020	COG2814	Major facilitator Superfamily
CPY64_RS01030	COG0656	L-ascorbic acid biosynthetic process
CPY64_RS01035	COG2814	Major facilitator Superfamily
CPY64_RS01040	COG0583	DNA-binding transcription factor activity
CPY64_RS01050	COG3685	Protein conserved in bacteria
CPY64_RS01070	COG1846	Transcriptional regulator
CPY64_RS01085	COG4774	siderophore transport
CPY64_RS01090	COG4607	ABC-type enterochelin transport system periplasmic component
CPY64_RS01095	COG4604	ABC transporter, ATP-binding protein
CPY64_RS01100	COG4605	iron ion homeostasis
CPY64_RS01105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPY64_RS01110	COG1132	(ABC) transporter
CPY64_RS01115	COG1132	(ABC) transporter
CPY64_RS01115	COG2375	cellular response to nickel ion
CPY64_RS01120	COG0277	FAD linked oxidase domain protein
CPY64_RS01125	COG1304	FMN binding
CPY64_RS01130	COG2186	Transcriptional regulator
CPY64_RS01150	COG1609	Transcriptional regulator
CPY64_RS01155	COG1522	sequence-specific DNA binding
CPY64_RS01160	COG3844	kynureninase activity
CPY64_RS01165	COG1113	amino acid transport
CPY64_RS01195	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS01200	COG1349	DNA-binding transcription factor activity
CPY64_RS01205	COG3842	ATPase activity
CPY64_RS01220	COG0395	ABC-type sugar transport system, permease component
CPY64_RS01245	COG0861	Integral membrane protein TerC family
CPY64_RS01250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPY64_RS01260	COG1671	Belongs to the UPF0178 family
CPY64_RS01270	COG1418	mRNA catabolic process
CPY64_RS01280	COG4948	Mandelate Racemase Muconate Lactonizing
CPY64_RS01290	COG0477	Major facilitator Superfamily
CPY64_RS01305	COG0154	amidase activity
CPY64_RS01315	COG0583	DNA-binding transcription factor activity
CPY64_RS01340	COG0326	Molecular chaperone. Has ATPase activity
CPY64_RS01350	COG3128	pkhd-type hydroxylase
CPY64_RS01360	COG3023	N-Acetylmuramoyl-L-alanine amidase
CPY64_RS01375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CPY64_RS01380	COG1652	LysM domain
CPY64_RS01395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPY64_RS01420	COG3433	isochorismatase activity
CPY64_RS01420	COG1535	isochorismatase
CPY64_RS01445	COG0583	DNA-binding transcription factor activity
CPY64_RS01450	COG0387	Pfam Sodium calcium exchanger
CPY64_RS01465	COG0477	Major facilitator Superfamily
CPY64_RS01470	COG0235	Class ii aldolase
CPY64_RS01480	COG3391	amine dehydrogenase activity
CPY64_RS01485	COG0590	tRNA wobble adenosine to inosine editing
CPY64_RS01490	COG3257	ureidoglycine aminohydrolase activity
CPY64_RS01495	COG0583	DNA-binding transcription factor activity
CPY64_RS01500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CPY64_RS01505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPY64_RS01505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPY64_RS01515	COG0489	protein tyrosine kinase activity
CPY64_RS01540	COG2081	HI0933 family
CPY64_RS01545	COG0509	glycine decarboxylation via glycine cleavage system
CPY64_RS01555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CPY64_RS01560	COG1765	OsmC-like protein
CPY64_RS01565	COG3278	Belongs to the heme-copper respiratory oxidase family
CPY64_RS01590	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CPY64_RS01595	COG0469	pyruvate kinase activity
CPY64_RS01600	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CPY64_RS01610	COG2084	Dehydrogenase
CPY64_RS01615	COG3622	Belongs to the hyi family
CPY64_RS01620	COG3960	tartronate-semialdehyde synthase activity
CPY64_RS01625	COG0583	DNA-binding transcription factor activity
CPY64_RS01635	COG2233	PERMEase
CPY64_RS01640	COG1942	4-Oxalocrotonate Tautomerase
CPY64_RS01645	COG0235	Class ii aldolase
CPY64_RS01655	COG3648	Uricase
CPY64_RS01655	COG3195	allantoin biosynthetic process
CPY64_RS01665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPY64_RS01670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CPY64_RS01685	COG0438	transferase activity, transferring glycosyl groups
CPY64_RS01695	COG0438	transferase activity, transferring glycosyl groups
CPY64_RS01705	COG0277	FAD linked oxidase domain protein
CPY64_RS01715	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPY64_RS01720	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CPY64_RS01730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPY64_RS01740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPY64_RS01750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CPY64_RS01765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPY64_RS01770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CPY64_RS01775	COG0193	aminoacyl-tRNA hydrolase activity
CPY64_RS01785	COG0012	GTP binding
CPY64_RS01805	COG1024	Enoyl-CoA hydratase
CPY64_RS01810	COG0367	asparagine synthase
CPY64_RS01825	COG0488	(ABC) transporter
CPY64_RS01840	COG0288	reversible hydration of carbon dioxide
CPY64_RS01845	COG0583	DNA-binding transcription factor activity
CPY64_RS01875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CPY64_RS01885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPY64_RS01890	COG3088	subunit of a heme lyase
CPY64_RS01895	COG4235	cytochrome complex assembly
CPY64_RS01900	COG0785	Cytochrome C biogenesis protein
CPY64_RS01910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPY64_RS01910	COG2169	Transcriptional regulator
CPY64_RS01930	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS01940	COG0411	ABC transporter
CPY64_RS01950	COG1858	cytochrome C peroxidase
CPY64_RS01955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CPY64_RS01960	COG1959	2 iron, 2 sulfur cluster binding
CPY64_RS01965	COG2346	COG2346, Truncated hemoglobins
CPY64_RS01970	COG0463	Glycosyl transferase, family 2
CPY64_RS02010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CPY64_RS02015	COG3383	formate dehydrogenase (NAD+) activity
CPY64_RS02030	COG1910	domain protein
CPY64_RS02035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPY64_RS02045	COG0303	'Molybdopterin
CPY64_RS02050	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPY64_RS02055	COG0314	molybdopterin synthase activity
CPY64_RS02065	COG0315	cyclic pyranopterin monophosphate synthase activity
CPY64_RS02095	COG0678	peroxiredoxin activity
CPY64_RS02110	COG0697	spore germination
CPY64_RS02115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPY64_RS02195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CPY64_RS02200	COG4535	Mg2 and Co2 transporter CorC
CPY64_RS02205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CPY64_RS02210	COG1702	phosphate starvation-inducible protein PhoH
CPY64_RS02215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPY64_RS02230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPY64_RS02235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPY64_RS02240	COG1862	Preprotein translocase
CPY64_RS02245	COG0343	queuine tRNA-ribosyltransferase activity
CPY64_RS02250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CPY64_RS02255	COG2027	D-alanyl-D-alanine carboxypeptidase
CPY64_RS02260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CPY64_RS02270	COG4575	ribosome binding
CPY64_RS02285	COG0583	DNA-binding transcription factor activity
CPY64_RS02300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPY64_RS02315	COG0154	amidase activity
CPY64_RS02325	COG0477	Major facilitator Superfamily
CPY64_RS02340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CPY64_RS02350	COG0436	Aminotransferase
CPY64_RS02360	COG0280	phosphate acetyltransferase
CPY64_RS02360	COG0281	malic enzyme
CPY64_RS02370	COG2732	(Barnase) inhibitor
CPY64_RS02375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CPY64_RS02380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPY64_RS02385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPY64_RS02390	COG0126	phosphoglycerate kinase activity
CPY64_RS02415	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPY64_RS02425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CPY64_RS02430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CPY64_RS02435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CPY64_RS02440	COG0009	L-threonylcarbamoyladenylate synthase
CPY64_RS02445	COG0596	Alpha beta hydrolase
CPY64_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS02450	COG2030	dehydratase
CPY64_RS02455	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS02465	COG0405	Gamma-glutamyltransferase
CPY64_RS02475	COG0579	oxidoreductase
CPY64_RS02480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CPY64_RS02485	COG0259	pyridoxamine-phosphate oxidase activity
CPY64_RS02495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CPY64_RS02510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPY64_RS02515	COG1215	transferase activity, transferring glycosyl groups
CPY64_RS02525	COG0488	(ABC) transporter
CPY64_RS02545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CPY64_RS02550	COG2894	cell division
CPY64_RS02560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPY64_RS02565	COG1271	oxidase subunit
CPY64_RS02570	COG1294	oxidase, subunit
CPY64_RS02575	COG0038	chloride channel
CPY64_RS02585	COG0514	ATP-dependent DNA helicase (RecQ)
CPY64_RS02590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPY64_RS02595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPY64_RS02600	COG0633	Ferredoxin
CPY64_RS02605	COG0488	(ABC) transporter
CPY64_RS02615	COG2001	Belongs to the MraZ family
CPY64_RS02620	COG0275	rRNA processing
CPY64_RS02625	COG3116	cell division
CPY64_RS02635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPY64_RS02640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPY64_RS02645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPY64_RS02655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPY64_RS02660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPY64_RS02665	COG1181	Belongs to the D-alanine--D-alanine ligase family
CPY64_RS02670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPY64_RS02685	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CPY64_RS02695	COG0739	heme binding
CPY64_RS02695	COG0741	lytic transglycosylase activity
CPY64_RS02695	COG1196	nuclear chromosome segregation
CPY64_RS02700	COG0653	protein targeting
CPY64_RS02710	COG2239	Acts as a magnesium transporter
CPY64_RS02720	COG1473	amidohydrolase
CPY64_RS02725	COG0318	PFAM AMP-dependent synthetase and ligase
CPY64_RS02735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CPY64_RS02735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS02750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPY64_RS02755	COG2011	ABC-type metal ion transport system permease component
CPY64_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS02770	COG0765	amino acid transport
CPY64_RS02775	COG1126	abc transporter atp-binding protein
CPY64_RS02785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CPY64_RS02800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPY64_RS02805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPY64_RS02810	COG0700	Nucleoside recognition
CPY64_RS02825	COG0204	Acyl-transferase
CPY64_RS02830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CPY64_RS02835	COG0751	glycine-tRNA ligase activity
CPY64_RS02840	COG0752	glycyl-tRNA synthetase alpha subunit
CPY64_RS02845	COG1024	Enoyl-CoA hydratase
CPY64_RS02855	COG1309	transcriptional regulator
CPY64_RS02865	COG2814	Major facilitator Superfamily
CPY64_RS02880	COG1573	uracil-dna glycosylase
CPY64_RS02885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CPY64_RS02890	COG0617	tRNA 3'-terminal CCA addition
CPY64_RS02900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPY64_RS02905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CPY64_RS02910	COG1953	Uracil, thiamine, allantoin
CPY64_RS02915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CPY64_RS02920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CPY64_RS02925	COG0586	Pfam SNARE associated Golgi protein
CPY64_RS02930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPY64_RS02935	COG0802	atpase or kinase
CPY64_RS02945	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS02950	COG0281	malic enzyme
CPY64_RS02950	COG0280	phosphate acetyltransferase
CPY64_RS02955	COG0583	DNA-binding transcription factor activity
CPY64_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS02965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPY64_RS02985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS03010	COG1733	regulation of RNA biosynthetic process
CPY64_RS03015	COG2910	NAD(P)H-binding
CPY64_RS03025	COG2223	nitrite transmembrane transporter activity
CPY64_RS03030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPY64_RS03035	COG4974	Belongs to the 'phage' integrase family
CPY64_RS03040	COG0725	ABC transporter, periplasmic molybdate-binding protein
CPY64_RS03045	COG4149	molybdate abc transporter
CPY64_RS03050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CPY64_RS03065	COG1074	ATP-dependent DNA helicase activity
CPY64_RS03100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS03110	COG3712	iron ion homeostasis
CPY64_RS03120	COG3391	amine dehydrogenase activity
CPY64_RS03125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPY64_RS03130	COG0505	Belongs to the CarA family
CPY64_RS03135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPY64_RS03155	COG2233	PERMEase
CPY64_RS03160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPY64_RS03165	COG1534	Rna-binding protein
CPY64_RS03170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CPY64_RS03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPY64_RS03180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPY64_RS03185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPY64_RS03195	COG0248	Ppx GppA phosphatase
CPY64_RS03200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CPY64_RS03220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPY64_RS03225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPY64_RS03275	COG1231	oxidoreductase activity
CPY64_RS03280	COG2010	Cytochrome c
CPY64_RS03285	COG2323	membrane
CPY64_RS03295	COG1368	sulfuric ester hydrolase activity
CPY64_RS03325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPY64_RS03335	COG3327	negative regulation of DNA-templated transcription, initiation
CPY64_RS03340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPY64_RS03355	COG0009	L-threonylcarbamoyladenylate synthase
CPY64_RS03360	COG1994	Peptidase M50
CPY64_RS03365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPY64_RS03370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CPY64_RS03385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CPY64_RS03395	COG0156	8-amino-7-oxononanoate synthase activity
CPY64_RS03400	COG2124	cytochrome p450
CPY64_RS03405	COG3135	benzoate transporter
CPY64_RS03415	COG2850	peptidyl-arginine hydroxylation
CPY64_RS03420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPY64_RS03425	COG3391	amine dehydrogenase activity
CPY64_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPY64_RS03440	COG1136	(ABC) transporter
CPY64_RS03440	COG0577	efflux transmembrane transporter activity
CPY64_RS03445	COG1538	Outer membrane efflux protein
CPY64_RS03450	COG0363	glucosamine-6-phosphate deaminase activity
CPY64_RS03455	COG1132	(ABC) transporter
CPY64_RS03465	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS03475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPY64_RS03485	COG0668	transmembrane transport
CPY64_RS03495	COG0604	alcohol dehydrogenase
CPY64_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS03495	COG3321	synthase
CPY64_RS03530	COG0154	amidase activity
CPY64_RS03535	COG2031	fatty acid transporter
CPY64_RS03550	COG0483	inositol monophosphate 1-phosphatase activity
CPY64_RS03555	COG1253	flavin adenine dinucleotide binding
CPY64_RS03560	COG1968	undecaprenyl-diphosphatase activity
CPY64_RS03580	COG0215	cysteine-tRNA ligase activity
CPY64_RS03590	COG0825	malonyl-CoA metabolic process
CPY64_RS03595	COG0037	tRNA processing
CPY64_RS03615	COG0330	HflC and HflK could
CPY64_RS03630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPY64_RS03650	COG4208	sulfate ABC transporter
CPY64_RS03655	COG3842	ATPase activity
CPY64_RS03665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CPY64_RS03695	COG1304	FMN binding
CPY64_RS03700	COG0435	Glutathione S-transferase
CPY64_RS03705	COG0655	NAD(P)H dehydrogenase (quinone) activity
CPY64_RS03725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CPY64_RS03730	COG2363	Small membrane protein
CPY64_RS03735	COG0598	Magnesium transport protein CorA
CPY64_RS03740	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS03750	COG0747	negative chemotaxis
CPY64_RS03760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPY64_RS03765	COG4172	Belongs to the ABC transporter superfamily
CPY64_RS03775	COG3284	Transcriptional regulator
CPY64_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS03785	COG1454	alcohol dehydrogenase
CPY64_RS03790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPY64_RS03815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CPY64_RS03845	COG3829	transcription factor binding
CPY64_RS03850	COG0477	Major facilitator Superfamily
CPY64_RS03860	COG0039	L-malate dehydrogenase activity
CPY64_RS03865	COG2188	Transcriptional regulator
CPY64_RS03870	COG2009	succinate dehydrogenase
CPY64_RS03880	COG1053	succinate dehydrogenase
CPY64_RS03885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPY64_RS03890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CPY64_RS03895	COG0372	Belongs to the citrate synthase family
CPY64_RS03900	COG2186	Transcriptional regulator
CPY64_RS03905	COG1620	l-lactate permease
CPY64_RS03910	COG0280	phosphate acetyltransferase
CPY64_RS03910	COG0281	malic enzyme
CPY64_RS03920	COG0567	Dehydrogenase, E1 component
CPY64_RS03925	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPY64_RS03930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPY64_RS03935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CPY64_RS03955	COG2183	response to ionizing radiation
CPY64_RS03960	COG1199	ATP-dependent helicase activity
CPY64_RS03970	COG1733	regulation of RNA biosynthetic process
CPY64_RS03985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS03985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CPY64_RS03990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS04000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CPY64_RS04000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS04015	COG0564	pseudouridine synthase activity
CPY64_RS04025	COG3243	poly(R)-hydroxyalkanoic acid synthase
CPY64_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS04035	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CPY64_RS04065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPY64_RS04070	COG1187	pseudouridine synthase activity
CPY64_RS04075	COG0779	Required for maturation of 30S ribosomal subunits
CPY64_RS04080	COG0195	Participates in both transcription termination and antitermination
CPY64_RS04080	COG2251	uridine kinase activity
CPY64_RS04090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPY64_RS04095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPY64_RS04100	COG1217	gtp-binding protein TYPA
CPY64_RS04105	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPY64_RS04115	COG4160	amino acid transport
CPY64_RS04120	COG4215	(ABC) transporter
CPY64_RS04140	COG1283	sodium-dependent phosphate transmembrane transporter activity
CPY64_RS04150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPY64_RS04165	COG0501	Belongs to the peptidase M48B family
CPY64_RS04180	COG1722	exodeoxyribonuclease VII activity
CPY64_RS04185	COG0142	geranyltranstransferase activity
CPY64_RS04195	COG1469	GTP cyclohydrolase I activity
CPY64_RS04200	COG0360	Binds together with S18 to 16S ribosomal RNA
CPY64_RS04205	COG2965	DNA replication, synthesis of RNA primer
CPY64_RS04210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPY64_RS04220	COG0305	Participates in initiation and elongation during chromosome replication
CPY64_RS04230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CPY64_RS04235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CPY64_RS04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CPY64_RS04250	COG0436	Aminotransferase
CPY64_RS04265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPY64_RS04270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CPY64_RS04275	COG1562	ergosterol biosynthetic process
CPY64_RS04280	COG1562	ergosterol biosynthetic process
CPY64_RS04285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPY64_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS04315	COG3842	ATPase activity
CPY64_RS04320	COG1176	ABC-type spermidine putrescine transport system, permease component I
CPY64_RS04325	COG1177	transmembrane transport
CPY64_RS04330	COG1393	Belongs to the ArsC family
CPY64_RS04335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CPY64_RS04340	COG0704	Plays a role in the regulation of phosphate uptake
CPY64_RS04345	COG4251	negative regulation of phosphorylation
CPY64_RS04345	COG5001	Diguanylate cyclase
CPY64_RS04345	COG3706	GGDEF domain
CPY64_RS04345	COG2203	Gaf domain
CPY64_RS04350	COG0659	secondary active sulfate transmembrane transporter activity
CPY64_RS04355	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CPY64_RS04360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CPY64_RS04360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CPY64_RS04365	COG1643	Atp-dependent helicase
CPY64_RS04375	COG0438	transferase activity, transferring glycosyl groups
CPY64_RS04380	COG0726	polysaccharide deacetylase
CPY64_RS04395	COG0438	transferase activity, transferring glycosyl groups
CPY64_RS04420	COG1132	(ABC) transporter
CPY64_RS04475	COG2186	Transcriptional regulator
CPY64_RS04480	COG0277	FAD linked oxidase domain protein
CPY64_RS04485	COG0277	FAD linked oxidase domain protein
CPY64_RS04490	COG0247	lactate metabolic process
CPY64_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS04565	COG0628	permease
CPY64_RS04570	COG1283	sodium-dependent phosphate transmembrane transporter activity
CPY64_RS04585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS04595	COG0697	spore germination
CPY64_RS04615	COG3094	Invasion gene expression up-regulator, SirB
CPY64_RS04625	COG0640	Transcriptional regulator
CPY64_RS04650	COG0659	secondary active sulfate transmembrane transporter activity
CPY64_RS04655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CPY64_RS04665	COG2314	TM2 domain
CPY64_RS04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPY64_RS04675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CPY64_RS04680	COG0791	NLP P60 protein
CPY64_RS04700	COG1360	Flagellar Motor Protein
CPY64_RS04710	COG0835	chemotaxis
CPY64_RS04715	COG0840	transmembrane signaling receptor activity
CPY64_RS04720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CPY64_RS04730	COG0745	RESPONSE REGULATOR receiver
CPY64_RS04735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CPY64_RS04745	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CPY64_RS04755	COG3550	peptidyl-serine autophosphorylation
CPY64_RS04780	COG1815	bacterial-type flagellum-dependent cell motility
CPY64_RS04785	COG1558	bacterial-type flagellum-dependent cell motility
CPY64_RS04790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CPY64_RS04830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CPY64_RS04855	COG2176	DNA-directed DNA polymerase activity
CPY64_RS04865	COG1987	bacterial-type flagellum assembly
CPY64_RS04880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CPY64_RS04905	COG1157	protein secretion by the type III secretion system
CPY64_RS04920	COG1766	The M ring may be actively involved in energy transduction
CPY64_RS04925	COG1677	Flagellar hook-basal body complex protein FliE
CPY64_RS04930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CPY64_RS04955	COG1334	flagellar protein FlaG
CPY64_RS04960	COG1191	sigma factor activity
CPY64_RS04985	COG0582	viral genome integration into host DNA
CPY64_RS05060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CPY64_RS05080	COG2733	membrane
CPY64_RS05085	COG0840	transmembrane signaling receptor activity
CPY64_RS05090	COG0840	transmembrane signaling receptor activity
CPY64_RS05115	COG2610	gluconate transmembrane transporter activity
CPY64_RS05140	COG4974	Belongs to the 'phage' integrase family
CPY64_RS05200	COG4128	Pfam Zonular occludens toxin
CPY64_RS05245	COG1538	Outer membrane efflux protein
CPY64_RS05250	COG4521	taurine ABC transporter
CPY64_RS05255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CPY64_RS05260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS05270	COG0583	DNA-binding transcription factor activity
CPY64_RS05275	COG2824	Alkylphosphonate utilization operon protein PhnA
CPY64_RS05285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS05315	COG1192	Involved in chromosome partitioning
CPY64_RS05325	COG1113	amino acid transport
CPY64_RS05345	COG0583	DNA-binding transcription factor activity
CPY64_RS05350	COG3755	Protein conserved in bacteria
CPY64_RS05355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPY64_RS05390	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPY64_RS05415	COG1278	Cold shock
CPY64_RS05420	COG0642	Histidine kinase
CPY64_RS05430	COG3278	Belongs to the heme-copper respiratory oxidase family
CPY64_RS05440	COG2863	cytochrome
CPY64_RS05445	COG3258	Cytochrome c
CPY64_RS05500	COG0025	NhaP-type Na H and K H
CPY64_RS05515	COG1289	transmembrane transporter activity
CPY64_RS05520	COG2252	PERMEase
CPY64_RS05540	COG1999	signal sequence binding
CPY64_RS05550	COG0069	glutamate synthase activity
CPY64_RS05560	COG1846	Transcriptional regulator
CPY64_RS05570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CPY64_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS05620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CPY64_RS05620	COG3264	Mechanosensitive ion channel
CPY64_RS05625	COG3264	Mechanosensitive ion channel
CPY64_RS05625	COG1511	domain protein
CPY64_RS05630	COG0477	Major facilitator Superfamily
CPY64_RS05645	COG1396	sequence-specific DNA binding
CPY64_RS05650	COG3437	response regulator, receiver
CPY64_RS05655	COG0784	Response regulator, receiver
CPY64_RS05655	COG2198	Histidine kinase
CPY64_RS05655	COG2205	protein histidine kinase activity
CPY64_RS05660	COG2239	Acts as a magnesium transporter
CPY64_RS05670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPY64_RS05675	COG1490	D-aminoacyl-tRNA deacylase activity
CPY64_RS05690	COG0456	acetyltransferase
CPY64_RS05700	COG0501	Belongs to the peptidase M48B family
CPY64_RS05705	COG2814	Major facilitator Superfamily
CPY64_RS05775	COG3706	GGDEF domain
CPY64_RS05790	COG1522	sequence-specific DNA binding
CPY64_RS05795	COG0626	cystathionine gamma-synthase activity
CPY64_RS05805	COG0494	nUDIX hydrolase
CPY64_RS05810	COG2832	Protein of unknown function (DUF454)
CPY64_RS05820	COG0137	argininosuccinate synthase activity
CPY64_RS05825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CPY64_RS05830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CPY64_RS05850	COG1609	Transcriptional regulator
CPY64_RS05860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CPY64_RS05870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CPY64_RS05875	COG2205	protein histidine kinase activity
CPY64_RS05880	COG0745	RESPONSE REGULATOR receiver
CPY64_RS05885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPY64_RS05895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPY64_RS05900	COG0268	Binds directly to 16S ribosomal RNA
CPY64_RS05905	COG0728	peptidoglycan biosynthetic process
CPY64_RS05915	COG0563	adenylate kinase activity
CPY64_RS05920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CPY64_RS05925	COG2835	tetraacyldisaccharide 4'-kinase activity
CPY64_RS05935	COG0848	biopolymer transport protein
CPY64_RS05940	COG0811	peptide transport
CPY64_RS05945	COG1570	exodeoxyribonuclease VII activity
CPY64_RS05950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CPY64_RS05960	COG0183	Belongs to the thiolase family
CPY64_RS05970	COG1278	Cold shock
CPY64_RS05975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CPY64_RS05980	COG0542	response to heat
CPY64_RS05985	COG2995	paraquat-inducible protein a
CPY64_RS05990	COG3008	intermembrane lipid transfer
CPY64_RS05990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CPY64_RS06040	COG0693	protein deglycase activity
CPY64_RS06045	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CPY64_RS06050	COG0756	dUTP diphosphatase activity
CPY64_RS06060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CPY64_RS06065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPY64_RS06070	COG0196	riboflavin kinase activity
CPY64_RS06075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPY64_RS06080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPY64_RS06080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPY64_RS06090	COG0210	DNA helicase
CPY64_RS06145	COG0488	(ABC) transporter
CPY64_RS06150	COG2890	protein-(glutamine-N5) methyltransferase activity
CPY64_RS06155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPY64_RS06160	COG2171	N-acyltransferase activity
CPY64_RS06170	COG2207	Transcriptional regulator
CPY64_RS06180	COG3273	potassium ion transport
CPY64_RS06180	COG0471	metal ion transport
CPY64_RS06225	COG0789	Transcriptional regulator
CPY64_RS06250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS06255	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPY64_RS06260	COG0740	serine-type endopeptidase activity
CPY64_RS06270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CPY64_RS06280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPY64_RS06290	COG0556	nucleotide-excision repair
CPY64_RS06295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPY64_RS06305	COG1104	cysteine desulfurase activity
CPY64_RS06315	COG0316	Belongs to the HesB IscA family
CPY64_RS06330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CPY64_RS06335	COG4221	oxidoreductase activity
CPY64_RS06345	COG0840	transmembrane signaling receptor activity
CPY64_RS06350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPY64_RS06355	COG0697	spore germination
CPY64_RS06360	COG0385	Bile acid
CPY64_RS06370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CPY64_RS06385	COG1136	(ABC) transporter
CPY64_RS06390	COG0084	hydrolase, TatD family'
CPY64_RS06405	COG0613	PHP domain protein
CPY64_RS06415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPY64_RS06415	COG0047	phosphoribosylformylglycinamidine synthase activity
CPY64_RS06440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CPY64_RS06440	COG0519	Catalyzes the synthesis of GMP from XMP
CPY64_RS06445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CPY64_RS06455	COG3311	Transcriptional regulator
CPY64_RS06470	COG2076	Multidrug Resistance protein
CPY64_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS06480	COG0583	DNA-binding transcription factor activity
CPY64_RS06495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CPY64_RS06505	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS06510	COG0523	cobalamin synthesis protein
CPY64_RS06515	COG1469	GTP cyclohydrolase I activity
CPY64_RS06520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPY64_RS06530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPY64_RS06535	COG0735	belongs to the Fur family
CPY64_RS06540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CPY64_RS06560	COG0745	RESPONSE REGULATOR receiver
CPY64_RS06565	COG2207	Transcriptional regulator
CPY64_RS06585	COG0583	DNA-binding transcription factor activity
CPY64_RS06590	COG1289	transmembrane transporter activity
CPY64_RS06600	COG1566	PFAM secretion protein HlyD family protein
CPY64_RS06610	COG1942	4-Oxalocrotonate Tautomerase
CPY64_RS06625	COG3162	membrane
CPY64_RS06630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPY64_RS06640	COG2070	2-Nitropropane dioxygenase
CPY64_RS06665	COG1309	transcriptional regulator
CPY64_RS06680	COG0625	glutathione transferase activity
CPY64_RS06685	COG0583	DNA-binding transcription factor activity
CPY64_RS06705	COG0625	glutathione transferase activity
CPY64_RS06710	COG0740	serine-type endopeptidase activity
CPY64_RS06765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS06775	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS06795	COG0640	Transcriptional regulator
CPY64_RS06820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPY64_RS06850	COG3485	protocatechuate 3,4-dioxygenase
CPY64_RS06860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CPY64_RS06865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPY64_RS06875	COG3135	benzoate transporter
CPY64_RS06880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CPY64_RS06885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CPY64_RS06900	COG4555	ABC transporter
CPY64_RS06910	COG2197	response regulator
CPY64_RS06915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CPY64_RS06940	COG1846	Transcriptional regulator
CPY64_RS06945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPY64_RS06950	COG2271	Major facilitator Superfamily
CPY64_RS06960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPY64_RS06970	COG0697	spore germination
CPY64_RS07000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CPY64_RS07005	COG0667	Aldo Keto reductase
CPY64_RS07020	COG0582	viral genome integration into host DNA
CPY64_RS07310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CPY64_RS07385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CPY64_RS07390	COG1335	isochorismatase
CPY64_RS07405	COG2135	peptidase activity
CPY64_RS07420	COG1272	protein, Hemolysin III
CPY64_RS07425	COG3422	double-strand break repair
CPY64_RS07445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS07450	COG0765	amino acid transport
CPY64_RS07455	COG0765	amino acid transport
CPY64_RS07460	COG1126	abc transporter atp-binding protein
CPY64_RS07515	COG2871	sodium ion transport
CPY64_RS07545	COG2814	Major facilitator Superfamily
CPY64_RS07550	COG1280	lysine exporter protein (LysE YggA)
CPY64_RS07570	COG0402	S-adenosylhomocysteine deaminase activity
CPY64_RS07595	COG0330	HflC and HflK could
CPY64_RS07600	COG1585	Membrane protein implicated in regulation of membrane protease activity
CPY64_RS07605	COG2226	methyltransferase
CPY64_RS07615	COG3042	response to heat
CPY64_RS07625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPY64_RS07640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPY64_RS07645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPY64_RS07660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPY64_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPY64_RS07695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPY64_RS07700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPY64_RS07705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CPY64_RS07710	COG0072	phenylalanine-tRNA ligase activity
CPY64_RS07710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPY64_RS07725	COG2833	Protein of unknown function (DUF455)
CPY64_RS07740	COG5265	(ABC) transporter
CPY64_RS07745	COG1959	2 iron, 2 sulfur cluster binding
CPY64_RS07750	COG0719	Fe-S assembly protein
CPY64_RS07755	COG0396	ATPase activity
CPY64_RS07760	COG0719	Fe-S assembly protein
CPY64_RS07770	COG0822	iron-sulfur transferase activity
CPY64_RS07775	COG2151	metal-sulfur cluster biosynthetic enzyme
CPY64_RS07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPY64_RS07845	COG3048	D-serine ammonia-lyase activity
CPY64_RS07850	COG3258	Cytochrome c
CPY64_RS07865	COG3949	Membrane
CPY64_RS07880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CPY64_RS07895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPY64_RS07900	COG0569	domain protein
CPY64_RS07905	COG1902	pentaerythritol trinitrate reductase activity
CPY64_RS07915	COG1610	YqeY-like protein
CPY64_RS07920	COG0587	DNA-directed DNA polymerase activity
CPY64_RS07955	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS07960	COG0583	DNA-binding transcription factor activity
CPY64_RS07965	COG1686	Belongs to the peptidase S11 family
CPY64_RS07980	COG1360	Flagellar Motor Protein
CPY64_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS08000	COG4221	oxidoreductase activity
CPY64_RS08005	COG0307	riboflavin synthase, alpha
CPY64_RS08020	COG1301	dicarboxylic acid transport
CPY64_RS08025	COG4191	Histidine kinase
CPY64_RS08070	COG2233	PERMEase
CPY64_RS08075	COG0071	Belongs to the small heat shock protein (HSP20) family
CPY64_RS08080	COG1473	amidohydrolase
CPY64_RS08090	COG2814	Major facilitator Superfamily
CPY64_RS08120	COG2816	NAD+ diphosphatase activity
CPY64_RS08125	COG1561	YicC-like family, N-terminal region
CPY64_RS08140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CPY64_RS08145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CPY64_RS08150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPY64_RS08155	COG0174	glutamine synthetase
CPY64_RS08160	COG2153	protein acetylation
CPY64_RS08180	COG3842	ATPase activity
CPY64_RS08185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CPY64_RS08190	COG1840	ABC-type Fe3 transport system, periplasmic component
CPY64_RS08205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPY64_RS08215	COG0783	Belongs to the Dps family
CPY64_RS08225	COG3842	ATPase activity
CPY64_RS08230	COG0395	ABC-type sugar transport system, permease component
CPY64_RS08235	COG1175	transmembrane transport
CPY64_RS08240	COG1653	transport
CPY64_RS08255	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS08275	COG0625	glutathione transferase activity
CPY64_RS08285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPY64_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS08295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPY64_RS08300	COG0114	fumarate hydratase activity
CPY64_RS08305	COG2133	pyrroloquinoline quinone binding
CPY64_RS08310	COG2226	methyltransferase
CPY64_RS08315	COG0589	response to stress
CPY64_RS08320	COG4654	Cytochrome c, class I
CPY64_RS08325	COG2207	Transcriptional regulator
CPY64_RS08330	COG0235	Class ii aldolase
CPY64_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS08345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPY64_RS08350	COG2807	transmembrane transport
CPY64_RS08360	COG0583	DNA-binding transcription factor activity
CPY64_RS08390	COG0583	DNA-binding transcription factor activity
CPY64_RS08395	COG4974	Belongs to the 'phage' integrase family
CPY64_RS08405	COG2132	Multicopper oxidase
CPY64_RS08410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CPY64_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS08455	COG3038	cytochrome b561
CPY64_RS08465	COG2353	YceI-like domain
CPY64_RS08470	COG1393	Belongs to the ArsC family
CPY64_RS08475	COG0625	glutathione transferase activity
CPY64_RS08495	COG0084	hydrolase, TatD family'
CPY64_RS08500	COG0470	DNA polymerase III
CPY64_RS08510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPY64_RS08530	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS08535	COG2914	Belongs to the UPF0125 (RnfH) family
CPY64_RS08540	COG2867	negative regulation of translational initiation
CPY64_RS08545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPY64_RS08550	COG1252	NADH dehydrogenase
CPY64_RS08575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPY64_RS08580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPY64_RS08585	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CPY64_RS08595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CPY64_RS08600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CPY64_RS08610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CPY64_RS08620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CPY64_RS08625	COG0575	Belongs to the CDS family
CPY64_RS08630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPY64_RS08635	COG0233	cytoplasmic translational termination
CPY64_RS08640	COG0528	UMP kinase activity
CPY64_RS08645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPY64_RS08650	COG0052	Belongs to the universal ribosomal protein uS2 family
CPY64_RS08655	COG0024	Methionine aminopeptidase
CPY64_RS08660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPY64_RS08685	COG1286	toxin biosynthetic process
CPY64_RS08695	COG0285	dihydrofolate synthase activity
CPY64_RS08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPY64_RS08705	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPY64_RS08710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CPY64_RS08725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPY64_RS08735	COG1999	signal sequence binding
CPY64_RS08745	COG0640	Transcriptional regulator
CPY64_RS08760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS08765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CPY64_RS08770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS08775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPY64_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS08805	COG0183	Belongs to the thiolase family
CPY64_RS08825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CPY64_RS08835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CPY64_RS08840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPY64_RS08845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CPY64_RS08870	COG0183	Belongs to the thiolase family
CPY64_RS08880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CPY64_RS08910	COG0194	GDP metabolic process
CPY64_RS08915	COG1758	RNA polymerase activity
CPY64_RS08920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPY64_RS08930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CPY64_RS08935	COG0739	heme binding
CPY64_RS08940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPY64_RS08945	COG0584	glycerophosphoryl diester phosphodiesterase
CPY64_RS08950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CPY64_RS08955	COG1187	pseudouridine synthase activity
CPY64_RS08960	COG3161	chorismate lyase activity
CPY64_RS08965	COG2814	Major facilitator Superfamily
CPY64_RS08970	COG0656	L-ascorbic acid biosynthetic process
CPY64_RS08980	COG0668	transmembrane transport
CPY64_RS08985	COG0165	Argininosuccinate lyase
CPY64_RS09000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS09010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CPY64_RS09020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CPY64_RS09025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CPY64_RS09030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CPY64_RS09035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CPY64_RS09040	COG2252	PERMEase
CPY64_RS09045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPY64_RS09065	COG0488	(ABC) transporter
CPY64_RS09070	COG1619	proteins homologs of microcin C7 resistance protein MccF
CPY64_RS09080	COG1131	(ABC) transporter
CPY64_RS09085	COG0842	Transport permease protein
CPY64_RS09095	COG1666	GTP binding
CPY64_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
CPY64_RS09105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPY64_RS09110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CPY64_RS09110	COG0519	Catalyzes the synthesis of GMP from XMP
CPY64_RS09115	COG2207	Transcriptional regulator
CPY64_RS09125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPY64_RS09130	COG0135	phosphoribosylanthranilate isomerase activity
CPY64_RS09135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS09145	COG0101	tRNA pseudouridine synthase activity
CPY64_RS09155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPY64_RS09180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPY64_RS09190	COG4566	intracellular signal transduction
CPY64_RS09205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPY64_RS09210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPY64_RS09220	COG1295	ribonuclease BN
CPY64_RS09230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CPY64_RS09265	COG4964	Belongs to the GSP D family
CPY64_RS09310	COG2959	enzyme of heme biosynthesis
CPY64_RS09320	COG0181	hydroxymethylbilane synthase activity
CPY64_RS09325	COG0861	Integral membrane protein TerC family
CPY64_RS09330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CPY64_RS09335	COG0045	succinate-CoA ligase (ADP-forming) activity
CPY64_RS09345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CPY64_RS09350	COG0583	DNA-binding transcription factor activity
CPY64_RS09355	COG2137	regulation of response to DNA damage stimulus
CPY64_RS09360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPY64_RS09375	COG0477	Major facilitator Superfamily
CPY64_RS09390	COG0318	PFAM AMP-dependent synthetase and ligase
CPY64_RS09395	COG1024	Enoyl-CoA hydratase
CPY64_RS09400	COG3162	membrane
CPY64_RS09415	COG0540	Belongs to the ATCase OTCase family
CPY64_RS09430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPY64_RS09445	COG2070	2-Nitropropane dioxygenase
CPY64_RS09455	COG2111	Na H antiporter
CPY64_RS09455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPY64_RS09460	COG1006	Multisubunit Na H antiporter MnhC subunit
CPY64_RS09465	COG0651	ATP synthesis coupled electron transport
CPY64_RS09475	COG2212	antiporter activity
CPY64_RS09490	COG0477	Major facilitator Superfamily
CPY64_RS09515	COG3158	transport of potassium into the cell
CPY64_RS09520	COG0642	Histidine kinase
CPY64_RS09545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CPY64_RS09550	COG4208	sulfate ABC transporter
CPY64_RS09555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CPY64_RS09560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CPY64_RS09575	COG1278	Cold shock
CPY64_RS09690	COG0740	serine-type endopeptidase activity
CPY64_RS09790	COG1396	sequence-specific DNA binding
CPY64_RS09900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPY64_RS09900	COG1648	precorrin-2 dehydrogenase activity
CPY64_RS09910	COG3391	amine dehydrogenase activity
CPY64_RS09930	COG0535	radical SAM domain protein
CPY64_RS09935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPY64_RS09935	COG1648	precorrin-2 dehydrogenase activity
CPY64_RS09945	COG2010	Cytochrome c
CPY64_RS09950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS09955	COG0626	cystathionine gamma-synthase activity
CPY64_RS09960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPY64_RS09965	COG0557	exoribonuclease II activity
CPY64_RS09985	COG0765	amino acid transport
CPY64_RS09990	COG0765	amino acid transport
CPY64_RS09995	COG1126	abc transporter atp-binding protein
CPY64_RS10010	COG1850	ribulose-bisphosphate carboxylase activity
CPY64_RS10030	COG2375	cellular response to nickel ion
CPY64_RS10060	COG0583	DNA-binding transcription factor activity
CPY64_RS10065	COG3842	ATPase activity
CPY64_RS10070	COG1175	transmembrane transport
CPY64_RS10075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CPY64_RS10080	COG1840	ABC-type Fe3 transport system, periplasmic component
CPY64_RS10100	COG0412	Dienelactone hydrolase
CPY64_RS10105	COG3530	Putative quorum-sensing-regulated virulence factor
CPY64_RS10110	COG0625	glutathione transferase activity
CPY64_RS10115	COG1741	Belongs to the pirin family
CPY64_RS10125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPY64_RS10130	COG2814	Major facilitator Superfamily
CPY64_RS10135	COG2807	transmembrane transport
CPY64_RS10140	COG2207	Transcriptional regulator
CPY64_RS10145	COG3135	benzoate transporter
CPY64_RS10170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPY64_RS10180	COG0402	S-adenosylhomocysteine deaminase activity
CPY64_RS10190	COG0745	RESPONSE REGULATOR receiver
CPY64_RS10195	COG2205	protein histidine kinase activity
CPY64_RS10210	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CPY64_RS10215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPY64_RS10220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CPY64_RS10230	COG0330	HflC and HflK could
CPY64_RS10235	COG0330	HflC and HflK could
CPY64_RS10240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPY64_RS10245	COG1923	regulation of RNA biosynthetic process
CPY64_RS10255	COG1160	GTP binding
CPY64_RS10260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CPY64_RS10265	COG2976	Protein conserved in bacteria
CPY64_RS10285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CPY64_RS10290	COG0105	UTP biosynthetic process
CPY64_RS10300	COG0336	Belongs to the RNA methyltransferase TrmD family
CPY64_RS10310	COG0228	four-way junction DNA binding
CPY64_RS10315	COG0425	Belongs to the sulfur carrier protein TusA family
CPY64_RS10320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPY64_RS10335	COG2351	hydroxyisourate hydrolase activity
CPY64_RS10370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS10395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CPY64_RS10400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPY64_RS10425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPY64_RS10430	COG0601	transmembrane transport
CPY64_RS10460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CPY64_RS10465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPY64_RS10470	COG0542	response to heat
CPY64_RS10475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPY64_RS10490	COG0348	domain, Protein
CPY64_RS10510	COG3278	Belongs to the heme-copper respiratory oxidase family
CPY64_RS10520	COG2217	Heavy metal translocating P-type atpase
CPY64_RS10525	COG2224	Isocitrate lyase
CPY64_RS10530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CPY64_RS10530	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CPY64_RS10550	COG1472	Belongs to the glycosyl hydrolase 3 family
CPY64_RS10555	COG0736	holo-[acyl-carrier-protein] synthase activity
CPY64_RS10565	COG2050	protein possibly involved in aromatic compounds catabolism
CPY64_RS10570	COG1024	Enoyl-CoA hydratase
CPY64_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS10580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CPY64_RS10585	COG2151	metal-sulfur cluster biosynthetic enzyme
CPY64_RS10590	COG3396	Phenylacetate-CoA oxygenase
CPY64_RS10595	COG3460	Phenylacetate-CoA oxygenase
CPY64_RS10600	COG3396	Phenylacetate-CoA oxygenase
CPY64_RS10605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CPY64_RS10610	COG0501	Belongs to the peptidase M48B family
CPY64_RS10615	COG1162	GTPase activity
CPY64_RS10625	COG0335	large ribosomal subunit rRNA binding
CPY64_RS10645	COG0450	alkyl hydroperoxide reductase
CPY64_RS10650	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS10670	COG2951	lytic endotransglycosylase activity
CPY64_RS10680	COG1596	polysaccharide export
CPY64_RS10680	COG1555	photosystem II stabilization
CPY64_RS10685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPY64_RS10690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CPY64_RS10695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CPY64_RS10715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPY64_RS10720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPY64_RS10725	COG0287	Prephenate dehydrogenase
CPY64_RS10735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CPY64_RS10750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPY64_RS10770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CPY64_RS10780	COG4771	TonB-dependent receptor
CPY64_RS10795	COG0753	catalase activity
CPY64_RS10805	COG4335	DNA alkylation repair
CPY64_RS10815	COG0436	Aminotransferase
CPY64_RS10825	COG0251	oxidation-reduction process
CPY64_RS10830	COG1309	transcriptional regulator
CPY64_RS10885	COG0625	glutathione transferase activity
CPY64_RS10895	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPY64_RS10900	COG1280	lysine exporter protein (LysE YggA)
CPY64_RS10920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPY64_RS10930	COG0784	Response regulator, receiver
CPY64_RS10930	COG2205	protein histidine kinase activity
CPY64_RS10930	COG2198	Histidine kinase
CPY64_RS10940	COG2046	Belongs to the sulfate adenylyltransferase family
CPY64_RS10945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CPY64_RS10950	COG0642	Histidine kinase
CPY64_RS10960	COG0840	transmembrane signaling receptor activity
CPY64_RS10965	COG2119	membrane
CPY64_RS10980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CPY64_RS10985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPY64_RS11000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CPY64_RS11005	COG2321	neutral zinc metallopeptidase
CPY64_RS11015	COG2271	Major facilitator Superfamily
CPY64_RS11020	COG2175	clavaminate synthase activity
CPY64_RS11025	COG1846	Transcriptional regulator
CPY64_RS11035	COG0347	Belongs to the P(II) protein family
CPY64_RS11040	COG0004	ammonium transporteR
CPY64_RS11045	COG3909	cytochrome
CPY64_RS11055	COG0625	glutathione transferase activity
CPY64_RS11060	COG0730	response to heat
CPY64_RS11065	COG0482	sulfurtransferase activity
CPY64_RS11070	COG0277	FAD linked oxidase domain protein
CPY64_RS11075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CPY64_RS11080	COG2879	small protein
CPY64_RS11085	COG1966	Carbon starvation protein
CPY64_RS11090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS11095	COG0765	amino acid transport
CPY64_RS11100	COG0765	amino acid transport
CPY64_RS11105	COG1126	abc transporter atp-binding protein
CPY64_RS11110	COG0028	Belongs to the TPP enzyme family
CPY64_RS11115	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS11120	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CPY64_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS11130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPY64_RS11130	COG0596	Alpha beta hydrolase
CPY64_RS11130	COG2226	methyltransferase
CPY64_RS11135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS11140	COG1116	anion transmembrane transporter activity
CPY64_RS11155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS11170	COG5285	phytanoyl-CoA dioxygenase
CPY64_RS11175	COG0662	Cupin 2, conserved barrel domain protein
CPY64_RS11185	COG0456	acetyltransferase
CPY64_RS11190	COG1846	Transcriptional regulator
CPY64_RS11200	COG0312	modulator of DNA gyrase
CPY64_RS11215	COG0308	aminopeptidase N
CPY64_RS11220	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CPY64_RS11235	COG0473	3-isopropylmalate dehydrogenase activity
CPY64_RS11245	COG0433	COG0433 Predicted ATPase
CPY64_RS11250	COG0217	transcriptional regulatory protein
CPY64_RS11255	COG0151	Belongs to the GarS family
CPY64_RS11265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPY64_RS11270	COG0799	negative regulation of ribosome biogenesis
CPY64_RS11275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CPY64_RS11280	COG0424	maF-like protein
CPY64_RS11300	COG0023	Translation Initiation Factor
CPY64_RS11310	COG2084	Dehydrogenase
CPY64_RS11315	COG0625	glutathione transferase activity
CPY64_RS11320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CPY64_RS11325	COG1047	Peptidyl-prolyl cis-trans
CPY64_RS11330	COG2003	Belongs to the UPF0758 family
CPY64_RS11335	COG1737	Transcriptional regulator
CPY64_RS11340	COG0477	Major facilitator Superfamily
CPY64_RS11350	COG2271	Major facilitator Superfamily
CPY64_RS11365	COG0534	Mate efflux family protein
CPY64_RS11370	COG4175	Glycine betaine
CPY64_RS11375	COG4176	ABC-type proline glycine betaine transport system permease component
CPY64_RS11385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CPY64_RS11395	COG2814	Major facilitator Superfamily
CPY64_RS11400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CPY64_RS11405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPY64_RS11410	COG0495	leucyl-tRNA aminoacylation
CPY64_RS11420	COG1466	dna polymerase III delta subunit
CPY64_RS11425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CPY64_RS11430	COG1981	membrane
CPY64_RS11445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CPY64_RS11455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CPY64_RS11460	COG0148	phosphopyruvate hydratase activity
CPY64_RS11470	COG2814	Major facilitator Superfamily
CPY64_RS11485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CPY64_RS11495	COG0504	CTP synthase activity
CPY64_RS11530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPY64_RS11540	COG0791	NLP P60 protein
CPY64_RS11550	COG0583	DNA-binding transcription factor activity
CPY64_RS11560	COG0583	DNA-binding transcription factor activity
CPY64_RS11570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CPY64_RS11585	COG1045	serine acetyltransferase
CPY64_RS11600	COG1381	Involved in DNA repair and RecF pathway recombination
CPY64_RS11605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CPY64_RS11610	COG0571	ribonuclease III activity
CPY64_RS11625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPY64_RS11650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPY64_RS11655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPY64_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS11665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPY64_RS11670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPY64_RS11680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPY64_RS11685	COG1399	metal-binding, possibly nucleic acid-binding protein
CPY64_RS11690	COG0424	maF-like protein
CPY64_RS11700	COG3023	N-Acetylmuramoyl-L-alanine amidase
CPY64_RS11705	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CPY64_RS11710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CPY64_RS11715	COG0546	phosphoglycolate phosphatase activity
CPY64_RS11720	COG0564	pseudouridine synthase activity
CPY64_RS11725	COG1530	ribonuclease E activity
CPY64_RS11730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CPY64_RS11735	COG0159	tryptophan synthase activity
CPY64_RS11740	COG0133	tryptophan synthase activity
CPY64_RS11745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPY64_RS11755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPY64_RS11760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CPY64_RS11770	COG2878	Part of a membrane complex involved in electron transport
CPY64_RS11775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CPY64_RS11780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CPY64_RS11785	COG3047	cAMP biosynthetic process
CPY64_RS11810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPY64_RS11815	COG2917	probably involved in intracellular septation
CPY64_RS11825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPY64_RS11830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CPY64_RS11840	COG1196	nuclear chromosome segregation
CPY64_RS11850	COG1573	uracil-dna glycosylase
CPY64_RS11855	COG1214	PFAM Peptidase M22, glycoprotease
CPY64_RS11870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CPY64_RS11875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CPY64_RS11880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CPY64_RS11885	COG0560	Phosphoserine phosphatase
CPY64_RS11900	COG1007	ATP synthesis coupled electron transport
CPY64_RS11915	COG0713	ATP synthesis coupled electron transport
CPY64_RS11925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPY64_RS11930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CPY64_RS11935	COG1034	ATP synthesis coupled electron transport
CPY64_RS11950	COG0649	NAD binding
CPY64_RS11955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPY64_RS11960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPY64_RS11965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPY64_RS11970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS11985	COG0149	triose-phosphate isomerase activity
CPY64_RS11990	COG0604	alcohol dehydrogenase
CPY64_RS12015	COG1185	polyribonucleotide nucleotidyltransferase activity
CPY64_RS12020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPY64_RS12025	COG1183	phosphatidylcholine synthase activity
CPY64_RS12030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPY64_RS12035	COG0440	acetolactate synthase activity
CPY64_RS12040	COG0028	Belongs to the TPP enzyme family
CPY64_RS12045	COG1289	transmembrane transporter activity
CPY64_RS12050	COG3022	response to hydroperoxide
CPY64_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS12125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CPY64_RS12130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPY64_RS12135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CPY64_RS12140	COG1674	ftsk spoiiie
CPY64_RS12145	COG0492	ferredoxin-NADP+ reductase activity
CPY64_RS12165	COG0477	Major facilitator Superfamily
CPY64_RS12185	COG2272	Belongs to the type-B carboxylesterase lipase family
CPY64_RS12190	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS12215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPY64_RS12235	COG2204	response regulator
CPY64_RS12275	COG4964	Belongs to the GSP D family
CPY64_RS12335	COG0612	Peptidase, M16
CPY64_RS12340	COG0484	heat shock protein binding
CPY64_RS12345	COG0443	Heat shock 70 kDa protein
CPY64_RS12350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPY64_RS12355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CPY64_RS12360	COG1420	regulation of RNA biosynthetic process
CPY64_RS12370	COG0497	DNA recombination
CPY64_RS12375	COG0735	belongs to the Fur family
CPY64_RS12380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CPY64_RS12385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CPY64_RS12410	COG0477	Major facilitator Superfamily
CPY64_RS12435	COG3122	Protein conserved in bacteria
CPY64_RS12445	COG3039	Transposase
CPY64_RS12455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CPY64_RS12485	COG1538	Outer membrane efflux protein
CPY64_RS12505	COG2271	Major facilitator Superfamily
CPY64_RS12525	COG2814	Major facilitator Superfamily
CPY64_RS12540	COG2819	hydrolase of the alpha beta superfamily
CPY64_RS12560	COG1454	alcohol dehydrogenase
CPY64_RS12570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPY64_RS12595	COG1414	Transcriptional regulator
CPY64_RS12600	COG0513	Belongs to the DEAD box helicase family
CPY64_RS12605	COG3657	addiction module killer protein
CPY64_RS12610	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPY64_RS12615	COG0583	DNA-binding transcription factor activity
CPY64_RS12620	COG4638	Rieske (2fe-2S)
CPY64_RS12625	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CPY64_RS12640	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPY64_RS12655	COG3971	2-oxopent-4-enoate hydratase activity
CPY64_RS12660	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CPY64_RS12665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPY64_RS12670	COG2814	Major facilitator Superfamily
CPY64_RS12685	COG0154	amidase activity
CPY64_RS12690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS12695	COG2814	Major facilitator Superfamily
CPY64_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS12730	COG0842	Transport permease protein
CPY64_RS12735	COG0842	Transport permease protein
CPY64_RS12735	COG1129	ABC transporter
CPY64_RS12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPY64_RS12750	COG3243	poly(R)-hydroxyalkanoic acid synthase
CPY64_RS12760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CPY64_RS12765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CPY64_RS12770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPY64_RS12785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPY64_RS12800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CPY64_RS12805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CPY64_RS12815	COG0789	Transcriptional regulator
CPY64_RS12825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CPY64_RS12875	COG3278	Belongs to the heme-copper respiratory oxidase family
CPY64_RS12880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS12900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CPY64_RS12945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPY64_RS13010	COG0517	IMP dehydrogenase activity
CPY64_RS13010	COG0516	GMP reductase activity
CPY64_RS13025	COG1027	Aspartate ammonia-lyase
CPY64_RS13030	COG1846	Transcriptional regulator
CPY64_RS13045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CPY64_RS13050	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CPY64_RS13070	COG1414	Transcriptional regulator
CPY64_RS13090	COG0513	Belongs to the DEAD box helicase family
CPY64_RS13110	COG0429	hydrolase of the alpha beta-hydrolase fold
CPY64_RS13135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPY64_RS13145	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CPY64_RS13155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CPY64_RS13160	COG0632	four-way junction helicase activity
CPY64_RS13170	COG2255	four-way junction helicase activity
CPY64_RS13180	COG0418	dihydroorotase activity
CPY64_RS13190	COG0415	Belongs to the DNA photolyase family
CPY64_RS13250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPY64_RS13255	COG4654	Cytochrome c, class I
CPY64_RS13295	COG1177	transmembrane transport
CPY64_RS13300	COG3842	ATPase activity
CPY64_RS13305	COG1840	ABC-type Fe3 transport system, periplasmic component
CPY64_RS13310	COG2084	Dehydrogenase
CPY64_RS13325	COG0494	nUDIX hydrolase
CPY64_RS13330	COG0442	prolyl-tRNA aminoacylation
CPY64_RS13335	COG0824	Thioesterase
CPY64_RS13340	COG0811	peptide transport
CPY64_RS13355	COG0823	Involved in the tonB-independent uptake of proteins
CPY64_RS13370	COG0596	Alpha beta hydrolase
CPY64_RS13395	COG1079	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS13400	COG4603	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS13405	COG3845	ABC transporter
CPY64_RS13425	COG0427	acetyl-CoA hydrolase
CPY64_RS13430	COG0583	DNA-binding transcription factor activity
CPY64_RS13440	COG3634	alkyl hydroperoxide reductase activity
CPY64_RS13455	COG0697	spore germination
CPY64_RS13460	COG0175	sulfate reduction
CPY64_RS13480	COG1012	belongs to the aldehyde dehydrogenase family
CPY64_RS13485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS13490	COG5383	Protein conserved in bacteria
CPY64_RS13500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPY64_RS13515	COG0583	DNA-binding transcription factor activity
CPY64_RS13520	COG1741	Belongs to the pirin family
CPY64_RS13530	COG3706	GGDEF domain
CPY64_RS13535	COG0154	amidase activity
CPY64_RS13550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CPY64_RS13560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CPY64_RS13565	COG0284	orotidine-5'-phosphate decarboxylase activity
CPY64_RS13580	COG1414	Transcriptional regulator
CPY64_RS13590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CPY64_RS13600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPY64_RS13605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPY64_RS13630	COG0742	ribosomal rna small subunit methyltransferase
CPY64_RS13635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CPY64_RS13640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CPY64_RS13670	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CPY64_RS13695	COG1335	isochorismatase
CPY64_RS13700	COG2309	aminopeptidase activity
CPY64_RS13705	COG0596	Alpha beta hydrolase
CPY64_RS13710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPY64_RS13710	COG2010	Cytochrome c
CPY64_RS13715	COG2080	2 iron, 2 sulfur cluster binding
CPY64_RS13720	COG2010	Cytochrome c
CPY64_RS13720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPY64_RS13730	COG0410	ABC transporter
CPY64_RS13735	COG0411	ABC transporter
CPY64_RS13775	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS13795	COG1234	tRNA 3'-trailer cleavage
CPY64_RS13800	COG2188	Transcriptional regulator
CPY64_RS13810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPY64_RS13820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPY64_RS13820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPY64_RS13825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CPY64_RS13825	COG3608	succinylglutamate desuccinylase aspartoacylase
CPY64_RS13830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS13840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPY64_RS13845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CPY64_RS13905	COG1335	isochorismatase
CPY64_RS13910	COG2309	aminopeptidase activity
CPY64_RS13915	COG0596	Alpha beta hydrolase
CPY64_RS13930	COG1120	ATPase activity
CPY64_RS13935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPY64_RS13945	COG4206	TonB-dependent receptor
CPY64_RS13950	COG2031	fatty acid transporter
CPY64_RS13955	COG0583	DNA-binding transcription factor activity
CPY64_RS13960	COG0402	S-adenosylhomocysteine deaminase activity
CPY64_RS13965	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS13980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CPY64_RS13985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPY64_RS13990	COG0328	RNA-DNA hybrid ribonuclease activity
CPY64_RS13995	COG2226	methyltransferase
CPY64_RS14000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPY64_RS14005	COG1388	LysM domain
CPY64_RS14005	COG0741	lytic transglycosylase activity
CPY64_RS14025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CPY64_RS14050	COG2204	response regulator
CPY64_RS14055	COG4191	Histidine kinase
CPY64_RS14060	COG1301	dicarboxylic acid transport
CPY64_RS14070	COG1054	Belongs to the UPF0176 family
CPY64_RS14095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPY64_RS14115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CPY64_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS14135	COG1877	trehalose-phosphatase activity
CPY64_RS14170	COG0604	alcohol dehydrogenase
CPY64_RS14180	COG1024	Enoyl-CoA hydratase
CPY64_RS14200	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CPY64_RS14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS14250	COG1393	Belongs to the ArsC family
CPY64_RS14255	COG0431	NADPH-dependent FMN reductase
CPY64_RS14260	COG0745	RESPONSE REGULATOR receiver
CPY64_RS14265	COG0642	Histidine kinase
CPY64_RS14280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPY64_RS14280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPY64_RS14285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPY64_RS14290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPY64_RS14295	COG1881	PFAM PEBP family protein
CPY64_RS14300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CPY64_RS14305	COG0739	heme binding
CPY64_RS14310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CPY64_RS14315	COG0316	Belongs to the HesB IscA family
CPY64_RS14325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPY64_RS14330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPY64_RS14335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CPY64_RS14340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CPY64_RS14345	COG0312	modulator of DNA gyrase
CPY64_RS14350	COG3028	Belongs to the UPF0307 family
CPY64_RS14375	COG4566	intracellular signal transduction
CPY64_RS14380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPY64_RS14385	COG4681	YaeQ
CPY64_RS14410	COG0762	integral membrane protein
CPY64_RS14425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPY64_RS14440	COG0439	Biotin carboxylase
CPY64_RS14445	COG0511	ligase activity, forming carbon-carbon bonds
CPY64_RS14450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPY64_RS14455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPY64_RS14460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPY64_RS14465	COG3150	esterase
CPY64_RS14480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPY64_RS14485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPY64_RS14495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CPY64_RS14510	COG1678	Uncharacterized ACR, COG1678
CPY64_RS14525	COG0352	thiamine-phosphate diphosphorylase activity
CPY64_RS14530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CPY64_RS14545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CPY64_RS14555	COG3237	CsbD-like
CPY64_RS14560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPY64_RS14565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPY64_RS14570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CPY64_RS14575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CPY64_RS14600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CPY64_RS14620	COG1126	abc transporter atp-binding protein
CPY64_RS14625	COG0765	amino acid transport
CPY64_RS14630	COG4597	amino acid ABC transporter
CPY64_RS14635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS14640	COG2884	Cell division ATP-binding protein ftsE
CPY64_RS14645	COG2177	Part of the ABC transporter FtsEX involved in
CPY64_RS14655	COG0772	Belongs to the SEDS family
CPY64_RS14660	COG0768	penicillin binding
CPY64_RS14670	COG1792	Involved in formation and maintenance of cell shape
CPY64_RS14675	COG1077	Cell shape determining protein MreB Mrl
CPY64_RS14680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPY64_RS14685	COG0154	amidase activity
CPY64_RS14690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPY64_RS14695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPY64_RS14700	COG0583	DNA-binding transcription factor activity
CPY64_RS14705	COG2259	Doxx family
CPY64_RS14710	COG3384	dioxygenase
CPY64_RS14720	COG3245	cytochrome
CPY64_RS14735	COG3604	Transcriptional regulator
CPY64_RS14750	COG0786	glutamate:sodium symporter activity
CPY64_RS14755	COG0142	geranyltranstransferase activity
CPY64_RS14765	COG0494	nUDIX hydrolase
CPY64_RS14770	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CPY64_RS14795	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CPY64_RS14800	COG0237	dephospho-CoA kinase activity
CPY64_RS14815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPY64_RS14820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPY64_RS14830	COG0477	Major facilitator Superfamily
CPY64_RS14835	COG0259	pyridoxamine-phosphate oxidase activity
CPY64_RS14885	COG4206	TonB-dependent receptor
CPY64_RS14890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPY64_RS14905	COG1595	DNA-templated transcription, initiation
CPY64_RS14915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS14935	COG0598	Magnesium transport protein CorA
CPY64_RS14950	COG2022	thiamine diphosphate biosynthetic process
CPY64_RS14955	COG0351	phosphomethylpyrimidine kinase
CPY64_RS14960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPY64_RS14965	COG3344	reverse transcriptase
CPY64_RS14970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CPY64_RS14975	COG1538	Outer membrane efflux protein
CPY64_RS14980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPY64_RS14990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CPY64_RS15005	COG2226	methyltransferase
CPY64_RS15010	COG0745	RESPONSE REGULATOR receiver
CPY64_RS15025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CPY64_RS15030	COG1984	allophanate hydrolase subunit 2
CPY64_RS15035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPY64_RS15040	COG1238	metal cluster binding
CPY64_RS15075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CPY64_RS15080	COG4988	ABC transporter
CPY64_RS15090	COG1294	oxidase, subunit
CPY64_RS15095	COG1271	oxidase subunit
CPY64_RS15110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CPY64_RS15125	COG1137	ATPase activity
CPY64_RS15135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPY64_RS15140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CPY64_RS15145	COG1660	Displays ATPase and GTPase activities
CPY64_RS15155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CPY64_RS15160	COG0792	nuclease activity
CPY64_RS15165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CPY64_RS15180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CPY64_RS15200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CPY64_RS15205	COG0793	Belongs to the peptidase S41A family
CPY64_RS15215	COG0588	phosphoglycerate mutase activity
CPY64_RS15220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPY64_RS15230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CPY64_RS15235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPY64_RS15240	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS15245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CPY64_RS15250	COG1040	competence protein
CPY64_RS15255	COG2226	methyltransferase
CPY64_RS15260	COG4771	TonB-dependent receptor
CPY64_RS15265	COG0745	RESPONSE REGULATOR receiver
CPY64_RS15280	COG2204	response regulator
CPY64_RS15300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPY64_RS15310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPY64_RS15315	COG3473	Maleate cis-trans isomerase
CPY64_RS15330	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CPY64_RS15345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPY64_RS15345	COG2755	lipolytic protein G-D-S-L family
CPY64_RS15355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPY64_RS15360	COG1216	Glycosyl transferase, family 2
CPY64_RS15370	COG3039	Transposase
CPY64_RS15445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CPY64_RS15455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPY64_RS15460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CPY64_RS15465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPY64_RS15480	COG0356	it plays a direct role in the translocation of protons across the membrane
CPY64_RS15490	COG1024	Enoyl-CoA hydratase
CPY64_RS15505	COG0037	tRNA processing
CPY64_RS15510	COG0163	prenyltransferase activity
CPY64_RS15515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CPY64_RS15520	COG2890	protein-(glutamine-N5) methyltransferase activity
CPY64_RS15560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPY64_RS15565	COG2264	protein methyltransferase activity
CPY64_RS15570	COG4773	Receptor
CPY64_RS15595	COG3180	Ammonia monooxygenase
CPY64_RS15615	COG5002	protein histidine kinase activity
CPY64_RS15630	COG0477	Major facilitator Superfamily
CPY64_RS15635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPY64_RS15655	COG1116	anion transmembrane transporter activity
CPY64_RS15680	COG3383	formate dehydrogenase (NAD+) activity
CPY64_RS15680	COG0243	molybdopterin cofactor binding
CPY64_RS15685	COG0243	molybdopterin cofactor binding
CPY64_RS15685	COG3383	formate dehydrogenase (NAD+) activity
CPY64_RS15690	COG0437	4 iron, 4 sulfur cluster binding
CPY64_RS15695	COG2864	formate dehydrogenase
CPY64_RS15705	COG1921	L-seryl-tRNASec selenium transferase activity
CPY64_RS15710	COG3276	selenocysteine insertion sequence binding
CPY64_RS15720	COG1476	TRANSCRIPTIONal
CPY64_RS15735	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS15755	COG0709	Synthesizes selenophosphate from selenide and ATP
CPY64_RS15770	COG0583	DNA-binding transcription factor activity
CPY64_RS15775	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CPY64_RS15780	COG0348	domain, Protein
CPY64_RS15780	COG3901	Regulator of nitric oxide reductase transcription
CPY64_RS15785	COG4263	nitrous-oxide reductase activity
CPY64_RS15800	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CPY64_RS15815	COG0166	Belongs to the GPI family
CPY64_RS15840	COG1215	transferase activity, transferring glycosyl groups
CPY64_RS15880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CPY64_RS15915	COG0156	8-amino-7-oxononanoate synthase activity
CPY64_RS15920	COG3321	synthase
CPY64_RS15920	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS15920	COG0604	alcohol dehydrogenase
CPY64_RS15930	COG2233	PERMEase
CPY64_RS15935	COG0697	spore germination
CPY64_RS15940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS15945	COG0697	spore germination
CPY64_RS15965	COG2885	chlorophyll binding
CPY64_RS16060	COG0183	Belongs to the thiolase family
CPY64_RS16065	COG1024	Enoyl-CoA hydratase
CPY64_RS16065	COG1250	3-hydroxyacyl-CoA dehydrogenase
CPY64_RS16080	COG1127	ABC transporter
CPY64_RS16085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CPY64_RS16090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CPY64_RS16105	COG1131	(ABC) transporter
CPY64_RS16110	COG0842	Transport permease protein
CPY64_RS16120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPY64_RS16130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CPY64_RS16135	COG0131	Imidazoleglycerol-phosphate dehydratase
CPY64_RS16145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CPY64_RS16150	COG0107	imidazoleglycerol-phosphate synthase activity
CPY64_RS16160	COG0140	phosphoribosyl-ATP diphosphatase activity
CPY64_RS16165	COG0537	adenosine 5'-monophosphoramidase activity
CPY64_RS16170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CPY64_RS16175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CPY64_RS16185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPY64_RS16195	COG1970	mechanosensitive ion channel activity
CPY64_RS16200	COG0723	plastoquinol--plastocyanin reductase activity
CPY64_RS16205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CPY64_RS16210	COG2857	Cytochrome c1
CPY64_RS16215	COG0625	glutathione transferase activity
CPY64_RS16220	COG2969	positive regulation of protein catabolic process
CPY64_RS16225	COG4208	sulfate ABC transporter
CPY64_RS16230	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CPY64_RS16235	COG4150	thiosulfate binding
CPY64_RS16250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPY64_RS16270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CPY64_RS16275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPY64_RS16280	COG3622	Belongs to the hyi family
CPY64_RS16290	COG0129	dihydroxy-acid dehydratase activity
CPY64_RS16295	COG1802	Transcriptional regulator
CPY64_RS16300	COG1522	sequence-specific DNA binding
CPY64_RS16305	COG3483	tryptophan 2,3-dioxygenase activity
CPY64_RS16325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CPY64_RS16330	COG0656	L-ascorbic acid biosynthetic process
CPY64_RS16340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CPY64_RS16345	COG3706	GGDEF domain
CPY64_RS16350	COG2226	methyltransferase
CPY64_RS16360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPY64_RS16375	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CPY64_RS16380	COG0583	DNA-binding transcription factor activity
CPY64_RS16385	COG0477	Major facilitator Superfamily
CPY64_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS16400	COG1335	isochorismatase
CPY64_RS16405	COG1335	isochorismatase
CPY64_RS16425	COG2823	Periplasmic or secreted lipoprotein
CPY64_RS16435	COG3284	Transcriptional regulator
CPY64_RS16465	COG1595	DNA-templated transcription, initiation
CPY64_RS16475	COG1522	sequence-specific DNA binding
CPY64_RS16485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPY64_RS16505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CPY64_RS16540	COG0109	protoheme IX farnesyltransferase activity
CPY64_RS16560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPY64_RS16565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPY64_RS16580	COG3568	Endonuclease Exonuclease Phosphatase
CPY64_RS16585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPY64_RS16610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS16620	COG1228	amidohydrolase
CPY64_RS16640	COG2986	histidine ammonia-lyase
CPY64_RS16645	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CPY64_RS16675	COG2814	Major facilitator Superfamily
CPY64_RS16685	COG0789	Transcriptional regulator
CPY64_RS16715	COG0625	glutathione transferase activity
CPY64_RS16725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CPY64_RS16725	COG1017	nitric oxide dioxygenase activity
CPY64_RS16745	COG2365	Tyrosine phosphatase family
CPY64_RS16750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CPY64_RS16770	COG2423	ornithine cyclodeaminase activity
CPY64_RS16820	COG3069	C4-dicarboxylate transmembrane transporter activity
CPY64_RS16830	COG1802	Transcriptional regulator
CPY64_RS16840	COG2814	Major facilitator Superfamily
CPY64_RS16855	COG2814	Major facilitator Superfamily
CPY64_RS16860	COG0251	oxidation-reduction process
CPY64_RS16865	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS16870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPY64_RS16875	COG2186	Transcriptional regulator
CPY64_RS16885	COG2814	Major facilitator Superfamily
CPY64_RS16895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CPY64_RS16900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CPY64_RS16905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CPY64_RS16925	COG5002	protein histidine kinase activity
CPY64_RS16925	COG5001	Diguanylate cyclase
CPY64_RS16945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPY64_RS16950	COG1333	cytochrome c biogenesis protein
CPY64_RS16960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CPY64_RS16965	COG0113	porphobilinogen synthase activity
CPY64_RS16970	COG4232	protein-disulfide reductase activity
CPY64_RS16990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPY64_RS16995	COG0203	ribosomal protein L17
CPY64_RS17000	COG0202	RNA polymerase activity
CPY64_RS17005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPY64_RS17010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CPY64_RS17015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CPY64_RS17020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CPY64_RS17030	COG0201	protein transport
CPY64_RS17035	COG0200	Binds to the 23S rRNA
CPY64_RS17040	COG1841	ribosomal large subunit assembly
CPY64_RS17045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPY64_RS17050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPY64_RS17055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CPY64_RS17060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CPY64_RS17065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPY64_RS17070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CPY64_RS17075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPY64_RS17080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPY64_RS17120	COG1538	Outer membrane efflux protein
CPY64_RS17125	COG3039	Transposase
CPY64_RS17140	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS17145	COG0183	Belongs to the thiolase family
CPY64_RS17155	COG2067	long-chain fatty acid transport protein
CPY64_RS17170	COG0318	PFAM AMP-dependent synthetase and ligase
CPY64_RS17175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CPY64_RS17180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CPY64_RS17185	COG1648	precorrin-2 dehydrogenase activity
CPY64_RS17185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPY64_RS17200	COG1116	anion transmembrane transporter activity
CPY64_RS17220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CPY64_RS17225	COG0255	Belongs to the universal ribosomal protein uL29 family
CPY64_RS17230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPY64_RS17235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPY64_RS17240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPY64_RS17245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPY64_RS17250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPY64_RS17255	COG0089	rRNA binding
CPY64_RS17260	COG0088	Forms part of the polypeptide exit tunnel
CPY64_RS17265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CPY64_RS17270	COG4175	Glycine betaine
CPY64_RS17275	COG4176	ABC-type proline glycine betaine transport system permease component
CPY64_RS17285	COG0051	transcription antitermination factor activity, RNA binding
CPY64_RS17290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPY64_RS17295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPY64_RS17300	COG0049	tRNA binding
CPY64_RS17305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CPY64_RS17310	COG0745	RESPONSE REGULATOR receiver
CPY64_RS17335	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CPY64_RS17340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPY64_RS17345	COG0085	RNA polymerase activity
CPY64_RS17350	COG0222	ribosome binding
CPY64_RS17355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CPY64_RS17365	COG0081	regulation of translation
CPY64_RS17390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPY64_RS17415	COG1475	DNA binding
CPY64_RS17420	COG1192	Involved in chromosome partitioning
CPY64_RS17425	COG0357	Ribosomal RNA small subunit methyltransferase G
CPY64_RS17430	COG0445	tRNA wobble uridine modification
CPY64_RS17435	COG0436	Aminotransferase
CPY64_RS17440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CPY64_RS17445	COG3706	GGDEF domain
CPY64_RS17450	COG0688	phosphatidylethanolamine metabolic process
CPY64_RS17460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPY64_RS17465	COG3039	Transposase
CPY64_RS17505	COG3645	SOS response
CPY64_RS17510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPY64_RS17555	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS17575	COG0596	Alpha beta hydrolase
CPY64_RS17580	COG2309	aminopeptidase activity
CPY64_RS17585	COG1335	isochorismatase
CPY64_RS17610	COG0753	catalase activity
CPY64_RS17615	COG0706	membrane insertase activity
CPY64_RS17620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPY64_RS17625	COG0594	ribonuclease P activity
CPY64_RS17630	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CPY64_RS17635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPY64_RS17640	COG0592	DNA-directed DNA polymerase activity
CPY64_RS17650	COG1187	pseudouridine synthase activity
CPY64_RS17665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS17695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CPY64_RS17700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPY64_RS17720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPY64_RS17740	COG2070	2-Nitropropane dioxygenase
CPY64_RS17750	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS17760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS17770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS17780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS17800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPY64_RS17805	COG0583	DNA-binding transcription factor activity
CPY64_RS17815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CPY64_RS17825	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS17840	COG0318	PFAM AMP-dependent synthetase and ligase
CPY64_RS17850	COG0596	Alpha beta hydrolase
CPY64_RS17850	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPY64_RS17855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPY64_RS17870	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS17880	COG0697	spore germination
CPY64_RS17885	COG0583	DNA-binding transcription factor activity
CPY64_RS17895	COG3842	ATPase activity
CPY64_RS17905	COG0436	Aminotransferase
CPY64_RS17915	COG0523	cobalamin synthesis protein
CPY64_RS17975	COG1846	Transcriptional regulator
CPY64_RS17995	COG0179	Fumarylacetoacetate (FAA) hydrolase
CPY64_RS18000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPY64_RS18005	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CPY64_RS18015	COG4638	Rieske (2fe-2S)
CPY64_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
CPY64_RS18090	COG2207	Transcriptional regulator
CPY64_RS18125	COG1595	DNA-templated transcription, initiation
CPY64_RS18130	COG4608	Belongs to the ABC transporter superfamily
CPY64_RS18135	COG0444	Belongs to the ABC transporter superfamily
CPY64_RS18140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPY64_RS18145	COG0601	transmembrane transport
CPY64_RS18155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPY64_RS18160	COG1595	DNA-templated transcription, initiation
CPY64_RS18165	COG3712	iron ion homeostasis
CPY64_RS18170	COG4774	siderophore transport
CPY64_RS18175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CPY64_RS18180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPY64_RS18195	COG1464	Belongs to the NlpA lipoprotein family
CPY64_RS18200	COG1464	Belongs to the NlpA lipoprotein family
CPY64_RS18205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPY64_RS18210	COG2011	ABC-type metal ion transport system permease component
CPY64_RS18235	COG1464	Belongs to the NlpA lipoprotein family
CPY64_RS18245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPY64_RS18265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPY64_RS18270	COG0431	NADPH-dependent FMN reductase
CPY64_RS18305	COG4149	molybdate abc transporter
CPY64_RS18315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CPY64_RS18320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPY64_RS18330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS18350	COG0028	Belongs to the TPP enzyme family
CPY64_RS18355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS18385	COG2922	Belongs to the Smg family
CPY64_RS18400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CPY64_RS18405	COG0183	Belongs to the thiolase family
CPY64_RS18410	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CPY64_RS18415	COG1960	acyl-CoA dehydrogenase activity
CPY64_RS18440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPY64_RS18450	COG0018	arginyl-trna synthetase
CPY64_RS18475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPY64_RS18485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CPY64_RS18490	COG4774	siderophore transport
CPY64_RS18495	COG0066	3-isopropylmalate dehydratase activity
CPY64_RS18500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPY64_RS18505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPY64_RS18510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CPY64_RS18515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CPY64_RS18515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS18525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CPY64_RS18530	COG1335	isochorismatase
CPY64_RS18535	COG0583	DNA-binding transcription factor activity
CPY64_RS18555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPY64_RS18560	COG1280	lysine exporter protein (LysE YggA)
CPY64_RS18565	COG0513	Belongs to the DEAD box helicase family
CPY64_RS18575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CPY64_RS18590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPY64_RS18605	COG0154	amidase activity
CPY64_RS18620	COG0583	DNA-binding transcription factor activity
CPY64_RS18650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CPY64_RS18655	COG1127	ABC transporter
CPY64_RS18660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CPY64_RS18660	COG3218	ABC-type transport auxiliary lipoprotein component
CPY64_RS18675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CPY64_RS18680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CPY64_RS18690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CPY64_RS18720	COG0583	DNA-binding transcription factor activity
CPY64_RS18740	COG3093	addiction module antidote protein HigA
CPY64_RS18765	COG2358	TRAP transporter, solute receptor (TAXI family
CPY64_RS18775	COG0564	pseudouridine synthase activity
CPY64_RS18780	COG0252	asparaginase activity
CPY64_RS18805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPY64_RS18810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPY64_RS18815	COG3181	Tripartite tricarboxylate transporter family receptor
CPY64_RS18835	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPY64_RS18860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPY64_RS18875	COG0758	DNA mediated transformation
CPY64_RS18880	COG0242	peptide deformylase activity
CPY64_RS18885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPY64_RS18890	COG0697	spore germination
CPY64_RS18905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component