locus-tag	class	description
I6H81_RS00015	COG1074	ATP-dependent DNA helicase activity
I6H81_RS00030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H81_RS00035	COG4149	molybdate abc transporter
I6H81_RS00040	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H81_RS00045	COG4974	Belongs to the 'phage' integrase family
I6H81_RS00050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H81_RS00055	COG2223	nitrite transmembrane transporter activity
I6H81_RS00065	COG2910	NAD(P)H-binding
I6H81_RS00070	COG1733	regulation of RNA biosynthetic process
I6H81_RS00100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS00120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H81_RS00125	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS00130	COG0583	DNA-binding transcription factor activity
I6H81_RS00135	COG0280	phosphate acetyltransferase
I6H81_RS00135	COG0281	malic enzyme
I6H81_RS00140	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS00150	COG0802	atpase or kinase
I6H81_RS00155	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H81_RS00160	COG0586	Pfam SNARE associated Golgi protein
I6H81_RS00165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H81_RS00170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H81_RS00175	COG1953	Uracil, thiamine, allantoin
I6H81_RS00180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H81_RS00185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H81_RS00195	COG0617	tRNA 3'-terminal CCA addition
I6H81_RS00200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H81_RS00205	COG1573	uracil-dna glycosylase
I6H81_RS00220	COG2814	Major facilitator Superfamily
I6H81_RS00230	COG1309	transcriptional regulator
I6H81_RS00240	COG1024	Enoyl-CoA hydratase
I6H81_RS00250	COG0752	glycyl-tRNA synthetase alpha subunit
I6H81_RS00255	COG0751	glycine-tRNA ligase activity
I6H81_RS00260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H81_RS00265	COG0204	Acyl-transferase
I6H81_RS00280	COG0700	Nucleoside recognition
I6H81_RS00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H81_RS00290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H81_RS00305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6H81_RS00315	COG1126	abc transporter atp-binding protein
I6H81_RS00320	COG0765	amino acid transport
I6H81_RS00325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS00335	COG2011	ABC-type metal ion transport system permease component
I6H81_RS00340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H81_RS00355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS00355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H81_RS00365	COG0318	PFAM AMP-dependent synthetase and ligase
I6H81_RS00370	COG1473	amidohydrolase
I6H81_RS00380	COG2239	Acts as a magnesium transporter
I6H81_RS00390	COG0653	protein targeting
I6H81_RS00395	COG1196	nuclear chromosome segregation
I6H81_RS00395	COG0739	heme binding
I6H81_RS00395	COG0741	lytic transglycosylase activity
I6H81_RS00405	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6H81_RS00420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H81_RS00425	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H81_RS00430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H81_RS00435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H81_RS00445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H81_RS00450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H81_RS00455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H81_RS00465	COG3116	cell division
I6H81_RS00470	COG0275	rRNA processing
I6H81_RS00475	COG2001	Belongs to the MraZ family
I6H81_RS00485	COG0488	(ABC) transporter
I6H81_RS00490	COG0633	Ferredoxin
I6H81_RS00495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H81_RS00500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H81_RS00505	COG0514	ATP-dependent DNA helicase (RecQ)
I6H81_RS00515	COG0038	chloride channel
I6H81_RS00520	COG1294	oxidase, subunit
I6H81_RS00525	COG1271	oxidase subunit
I6H81_RS00530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H81_RS00540	COG2894	cell division
I6H81_RS00545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6H81_RS00565	COG0488	(ABC) transporter
I6H81_RS00575	COG1215	transferase activity, transferring glycosyl groups
I6H81_RS00580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H81_RS00595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H81_RS00605	COG0259	pyridoxamine-phosphate oxidase activity
I6H81_RS00610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H81_RS00615	COG0579	oxidoreductase
I6H81_RS00625	COG0405	Gamma-glutamyltransferase
I6H81_RS00635	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS00640	COG2030	dehydratase
I6H81_RS00640	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS00645	COG0596	Alpha beta hydrolase
I6H81_RS00650	COG0009	L-threonylcarbamoyladenylate synthase
I6H81_RS00655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H81_RS00660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H81_RS00665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H81_RS00675	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H81_RS00700	COG0126	phosphoglycerate kinase activity
I6H81_RS00705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H81_RS00710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H81_RS00715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H81_RS00720	COG2732	(Barnase) inhibitor
I6H81_RS00730	COG0280	phosphate acetyltransferase
I6H81_RS00730	COG0281	malic enzyme
I6H81_RS00740	COG0436	Aminotransferase
I6H81_RS00750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6H81_RS00765	COG0477	Major facilitator Superfamily
I6H81_RS00775	COG0154	amidase activity
I6H81_RS00790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H81_RS00805	COG0583	DNA-binding transcription factor activity
I6H81_RS00820	COG4575	ribosome binding
I6H81_RS00830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H81_RS00835	COG2027	D-alanyl-D-alanine carboxypeptidase
I6H81_RS00840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H81_RS00845	COG0343	queuine tRNA-ribosyltransferase activity
I6H81_RS00850	COG1862	Preprotein translocase
I6H81_RS00855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H81_RS00860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H81_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H81_RS00880	COG1702	phosphate starvation-inducible protein PhoH
I6H81_RS00885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H81_RS00890	COG4535	Mg2 and Co2 transporter CorC
I6H81_RS00895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6H81_RS00975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H81_RS00980	COG0697	spore germination
I6H81_RS00995	COG0678	peroxiredoxin activity
I6H81_RS01025	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H81_RS01035	COG0314	molybdopterin synthase activity
I6H81_RS01040	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H81_RS01045	COG0303	'Molybdopterin
I6H81_RS01055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H81_RS01060	COG1910	domain protein
I6H81_RS01075	COG3383	formate dehydrogenase (NAD+) activity
I6H81_RS01080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H81_RS01120	COG0463	Glycosyl transferase, family 2
I6H81_RS01125	COG2346	COG2346, Truncated hemoglobins
I6H81_RS01130	COG1959	2 iron, 2 sulfur cluster binding
I6H81_RS01135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H81_RS01140	COG1858	cytochrome C peroxidase
I6H81_RS01150	COG0411	ABC transporter
I6H81_RS01160	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS01180	COG2169	Transcriptional regulator
I6H81_RS01180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H81_RS01190	COG0785	Cytochrome C biogenesis protein
I6H81_RS01195	COG4235	cytochrome complex assembly
I6H81_RS01200	COG3088	subunit of a heme lyase
I6H81_RS01205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H81_RS01215	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6H81_RS01245	COG0583	DNA-binding transcription factor activity
I6H81_RS01250	COG0288	reversible hydration of carbon dioxide
I6H81_RS01265	COG0488	(ABC) transporter
I6H81_RS01280	COG0367	asparagine synthase
I6H81_RS01285	COG1024	Enoyl-CoA hydratase
I6H81_RS01305	COG0012	GTP binding
I6H81_RS01315	COG0193	aminoacyl-tRNA hydrolase activity
I6H81_RS01320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H81_RS01325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H81_RS01340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H81_RS01350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H81_RS01360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H81_RS01370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6H81_RS01375	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H81_RS01385	COG0277	FAD linked oxidase domain protein
I6H81_RS01395	COG0438	transferase activity, transferring glycosyl groups
I6H81_RS01405	COG0438	transferase activity, transferring glycosyl groups
I6H81_RS01420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H81_RS01425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H81_RS01435	COG3648	Uricase
I6H81_RS01435	COG3195	allantoin biosynthetic process
I6H81_RS01445	COG0235	Class ii aldolase
I6H81_RS01450	COG1942	4-Oxalocrotonate Tautomerase
I6H81_RS01455	COG2233	PERMEase
I6H81_RS01465	COG0583	DNA-binding transcription factor activity
I6H81_RS01470	COG3960	tartronate-semialdehyde synthase activity
I6H81_RS01475	COG3622	Belongs to the hyi family
I6H81_RS01480	COG2084	Dehydrogenase
I6H81_RS01490	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6H81_RS01495	COG0469	pyruvate kinase activity
I6H81_RS01500	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6H81_RS01525	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H81_RS01530	COG1765	OsmC-like protein
I6H81_RS01535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H81_RS01545	COG0509	glycine decarboxylation via glycine cleavage system
I6H81_RS01550	COG2081	HI0933 family
I6H81_RS01575	COG0489	protein tyrosine kinase activity
I6H81_RS01585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H81_RS01585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H81_RS01590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H81_RS01595	COG0583	DNA-binding transcription factor activity
I6H81_RS01600	COG3257	ureidoglycine aminohydrolase activity
I6H81_RS01605	COG0590	tRNA wobble adenosine to inosine editing
I6H81_RS01610	COG3391	amine dehydrogenase activity
I6H81_RS01620	COG0235	Class ii aldolase
I6H81_RS01625	COG0477	Major facilitator Superfamily
I6H81_RS01640	COG0387	Pfam Sodium calcium exchanger
I6H81_RS01645	COG0583	DNA-binding transcription factor activity
I6H81_RS01670	COG3433	isochorismatase activity
I6H81_RS01670	COG1535	isochorismatase
I6H81_RS01695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H81_RS01710	COG1652	LysM domain
I6H81_RS01715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H81_RS01730	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H81_RS01740	COG3128	pkhd-type hydroxylase
I6H81_RS01750	COG0326	Molecular chaperone. Has ATPase activity
I6H81_RS01775	COG0583	DNA-binding transcription factor activity
I6H81_RS01785	COG0154	amidase activity
I6H81_RS01800	COG0477	Major facilitator Superfamily
I6H81_RS01810	COG4948	Mandelate Racemase Muconate Lactonizing
I6H81_RS01820	COG1418	mRNA catabolic process
I6H81_RS01830	COG1671	Belongs to the UPF0178 family
I6H81_RS01840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H81_RS01845	COG0861	Integral membrane protein TerC family
I6H81_RS01870	COG0395	ABC-type sugar transport system, permease component
I6H81_RS01885	COG3842	ATPase activity
I6H81_RS01890	COG1349	DNA-binding transcription factor activity
I6H81_RS01895	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS01925	COG1113	amino acid transport
I6H81_RS01930	COG3844	kynureninase activity
I6H81_RS01935	COG1522	sequence-specific DNA binding
I6H81_RS01940	COG1609	Transcriptional regulator
I6H81_RS01960	COG2186	Transcriptional regulator
I6H81_RS01965	COG1304	FMN binding
I6H81_RS01970	COG0277	FAD linked oxidase domain protein
I6H81_RS01975	COG2375	cellular response to nickel ion
I6H81_RS01975	COG1132	(ABC) transporter
I6H81_RS01980	COG1132	(ABC) transporter
I6H81_RS01985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H81_RS01990	COG4605	iron ion homeostasis
I6H81_RS01995	COG4604	ABC transporter, ATP-binding protein
I6H81_RS02000	COG4607	ABC-type enterochelin transport system periplasmic component
I6H81_RS02005	COG4774	siderophore transport
I6H81_RS02020	COG1846	Transcriptional regulator
I6H81_RS02040	COG3685	Protein conserved in bacteria
I6H81_RS02050	COG0583	DNA-binding transcription factor activity
I6H81_RS02055	COG2814	Major facilitator Superfamily
I6H81_RS02060	COG0656	L-ascorbic acid biosynthetic process
I6H81_RS02070	COG2814	Major facilitator Superfamily
I6H81_RS02085	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H81_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS02125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS02140	COG0628	permease
I6H81_RS02150	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS02170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H81_RS02175	COG0129	dihydroxy-acid dehydratase activity
I6H81_RS02180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6H81_RS02185	COG0730	response to heat
I6H81_RS02190	COG0275	rRNA processing
I6H81_RS02225	COG1950	PFAM Membrane protein of
I6H81_RS02230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6H81_RS02235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H81_RS02245	COG1560	Kdo2-lipid A biosynthetic process
I6H81_RS02250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H81_RS02260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6H81_RS02265	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H81_RS02270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H81_RS02285	COG0735	belongs to the Fur family
I6H81_RS02290	COG0523	cobalamin synthesis protein
I6H81_RS02300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6H81_RS02305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6H81_RS02320	COG2096	Adenosyltransferase
I6H81_RS02335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H81_RS02350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H81_RS02360	COG1280	lysine exporter protein (LysE YggA)
I6H81_RS02375	COG5295	Hep Hag repeat protein
I6H81_RS02390	COG0251	oxidation-reduction process
I6H81_RS02405	COG1346	cytolysis
I6H81_RS02410	COG2860	membrane
I6H81_RS02415	COG2223	nitrite transmembrane transporter activity
I6H81_RS02425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H81_RS02430	COG2197	response regulator
I6H81_RS02440	COG2918	glutathione biosynthetic process
I6H81_RS02470	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H81_RS02475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS02485	COG1024	Enoyl-CoA hydratase
I6H81_RS02490	COG0069	glutamate synthase activity
I6H81_RS02490	COG0067	glutamate synthase
I6H81_RS02490	COG0070	glutamate synthase
I6H81_RS02505	COG0210	DNA helicase
I6H81_RS02510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H81_RS02515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H81_RS02540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H81_RS02550	COG3391	amine dehydrogenase activity
I6H81_RS02565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H81_RS02575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H81_RS02580	COG0765	amino acid transport
I6H81_RS02585	COG0765	amino acid transport
I6H81_RS02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS02600	COG0583	DNA-binding transcription factor activity
I6H81_RS02610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6H81_RS02615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H81_RS02635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H81_RS02655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H81_RS02690	COG1253	flavin adenine dinucleotide binding
I6H81_RS02700	COG0583	DNA-binding transcription factor activity
I6H81_RS02710	COG2814	Major facilitator Superfamily
I6H81_RS02715	COG0513	Belongs to the DEAD box helicase family
I6H81_RS02720	COG2819	hydrolase of the alpha beta superfamily
I6H81_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H81_RS02730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H81_RS02765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H81_RS02780	COG0683	leucine binding
I6H81_RS02810	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H81_RS02815	COG1535	isochorismatase
I6H81_RS02815	COG3433	isochorismatase activity
I6H81_RS02820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H81_RS02820	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6H81_RS02835	COG1169	isochorismate synthase
I6H81_RS02840	COG3433	isochorismatase activity
I6H81_RS02840	COG1535	isochorismatase
I6H81_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS02855	COG0840	transmembrane signaling receptor activity
I6H81_RS02865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H81_RS02870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H81_RS02875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6H81_RS02880	COG2967	ApaG domain
I6H81_RS02885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H81_RS02895	COG0546	phosphoglycolate phosphatase activity
I6H81_RS02905	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H81_RS02910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H81_RS02915	COG0134	indole-3-glycerol-phosphate synthase activity
I6H81_RS02940	COG3154	lipid carrier protein
I6H81_RS02950	COG0826	peptidase U32
I6H81_RS02995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H81_RS03005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H81_RS03010	COG1024	Enoyl-CoA hydratase
I6H81_RS03015	COG0321	lipoyl(octanoyl) transferase activity
I6H81_RS03020	COG2921	Belongs to the UPF0250 family
I6H81_RS03030	COG1686	Belongs to the peptidase S11 family
I6H81_RS03040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H81_RS03040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H81_RS03045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H81_RS03050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H81_RS03055	COG1278	Cold shock
I6H81_RS03065	COG0859	PFAM glycosyl transferase family 9
I6H81_RS03070	COG0583	DNA-binding transcription factor activity
I6H81_RS03075	COG4336	lyase activity
I6H81_RS03090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS03105	COG0697	spore germination
I6H81_RS03110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H81_RS03115	COG0242	peptide deformylase activity
I6H81_RS03120	COG0758	DNA mediated transformation
I6H81_RS03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS03160	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS03180	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS03185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H81_RS03190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H81_RS03215	COG0252	asparaginase activity
I6H81_RS03220	COG0564	pseudouridine synthase activity
I6H81_RS03230	COG2358	TRAP transporter, solute receptor (TAXI family
I6H81_RS03255	COG3093	addiction module antidote protein HigA
I6H81_RS03275	COG0583	DNA-binding transcription factor activity
I6H81_RS03305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS03315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H81_RS03335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H81_RS03335	COG3218	ABC-type transport auxiliary lipoprotein component
I6H81_RS03340	COG1127	ABC transporter
I6H81_RS03345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H81_RS03375	COG0583	DNA-binding transcription factor activity
I6H81_RS03390	COG0154	amidase activity
I6H81_RS03405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H81_RS03420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6H81_RS03430	COG0513	Belongs to the DEAD box helicase family
I6H81_RS03435	COG1280	lysine exporter protein (LysE YggA)
I6H81_RS03440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H81_RS03460	COG0583	DNA-binding transcription factor activity
I6H81_RS03465	COG1335	isochorismatase
I6H81_RS03470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS03480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H81_RS03480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS03485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H81_RS03495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H81_RS03500	COG0066	3-isopropylmalate dehydratase activity
I6H81_RS03505	COG4774	siderophore transport
I6H81_RS03510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6H81_RS03525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H81_RS03550	COG0018	arginyl-trna synthetase
I6H81_RS03560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H81_RS03580	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS03585	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6H81_RS03590	COG0183	Belongs to the thiolase family
I6H81_RS03595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H81_RS03610	COG2922	Belongs to the Smg family
I6H81_RS03640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS03645	COG0028	Belongs to the TPP enzyme family
I6H81_RS03665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS03675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H81_RS03680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6H81_RS03690	COG4149	molybdate abc transporter
I6H81_RS03725	COG0431	NADPH-dependent FMN reductase
I6H81_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H81_RS03750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H81_RS03760	COG1464	Belongs to the NlpA lipoprotein family
I6H81_RS03785	COG2011	ABC-type metal ion transport system permease component
I6H81_RS03790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H81_RS03795	COG1464	Belongs to the NlpA lipoprotein family
I6H81_RS03800	COG1464	Belongs to the NlpA lipoprotein family
I6H81_RS03815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H81_RS03820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H81_RS03825	COG4774	siderophore transport
I6H81_RS03830	COG3712	iron ion homeostasis
I6H81_RS03835	COG1595	DNA-templated transcription, initiation
I6H81_RS03840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H81_RS03850	COG0601	transmembrane transport
I6H81_RS03855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H81_RS03860	COG0444	Belongs to the ABC transporter superfamily
I6H81_RS03865	COG4608	Belongs to the ABC transporter superfamily
I6H81_RS03870	COG1595	DNA-templated transcription, initiation
I6H81_RS03900	COG2207	Transcriptional regulator
I6H81_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS03975	COG4638	Rieske (2fe-2S)
I6H81_RS03985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6H81_RS03990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H81_RS03995	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H81_RS04015	COG1846	Transcriptional regulator
I6H81_RS04075	COG0523	cobalamin synthesis protein
I6H81_RS04085	COG0436	Aminotransferase
I6H81_RS04095	COG3842	ATPase activity
I6H81_RS04105	COG0583	DNA-binding transcription factor activity
I6H81_RS04110	COG0697	spore germination
I6H81_RS04120	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS04135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS04140	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H81_RS04140	COG0596	Alpha beta hydrolase
I6H81_RS04150	COG0318	PFAM AMP-dependent synthetase and ligase
I6H81_RS04165	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS04175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS04185	COG0583	DNA-binding transcription factor activity
I6H81_RS04190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H81_RS04210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS04220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS04230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS04240	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS04250	COG2070	2-Nitropropane dioxygenase
I6H81_RS04270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H81_RS04295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS04325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS04340	COG1187	pseudouridine synthase activity
I6H81_RS04350	COG0592	DNA-directed DNA polymerase activity
I6H81_RS04355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H81_RS04360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H81_RS04365	COG0594	ribonuclease P activity
I6H81_RS04370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H81_RS04375	COG0706	membrane insertase activity
I6H81_RS04380	COG0753	catalase activity
I6H81_RS04405	COG1335	isochorismatase
I6H81_RS04410	COG2309	aminopeptidase activity
I6H81_RS04415	COG0596	Alpha beta hydrolase
I6H81_RS04435	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS04470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H81_RS04475	COG3645	SOS response
I6H81_RS04515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H81_RS04525	COG0688	phosphatidylethanolamine metabolic process
I6H81_RS04530	COG3706	GGDEF domain
I6H81_RS04540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H81_RS04545	COG0436	Aminotransferase
I6H81_RS04550	COG0445	tRNA wobble uridine modification
I6H81_RS04555	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H81_RS04560	COG1192	Involved in chromosome partitioning
I6H81_RS04565	COG1475	DNA binding
I6H81_RS04585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H81_RS04610	COG0081	regulation of translation
I6H81_RS04615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H81_RS04620	COG0222	ribosome binding
I6H81_RS04625	COG0085	RNA polymerase activity
I6H81_RS04630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H81_RS04635	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6H81_RS04660	COG0745	RESPONSE REGULATOR receiver
I6H81_RS04665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H81_RS04670	COG0049	tRNA binding
I6H81_RS04675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H81_RS04680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H81_RS04685	COG0051	transcription antitermination factor activity, RNA binding
I6H81_RS04690	COG4176	ABC-type proline glycine betaine transport system permease component
I6H81_RS04695	COG4175	Glycine betaine
I6H81_RS04700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H81_RS04705	COG0088	Forms part of the polypeptide exit tunnel
I6H81_RS04710	COG0089	rRNA binding
I6H81_RS04715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H81_RS04720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H81_RS04725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H81_RS04730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H81_RS04735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H81_RS04740	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H81_RS04745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H81_RS04765	COG1116	anion transmembrane transporter activity
I6H81_RS04780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H81_RS04780	COG1648	precorrin-2 dehydrogenase activity
I6H81_RS04785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H81_RS04790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6H81_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
I6H81_RS04810	COG2067	long-chain fatty acid transport protein
I6H81_RS04820	COG0183	Belongs to the thiolase family
I6H81_RS04825	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS04840	COG1538	Outer membrane efflux protein
I6H81_RS04880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H81_RS04885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H81_RS04890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H81_RS04895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H81_RS04900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H81_RS04905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H81_RS04910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H81_RS04915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H81_RS04920	COG1841	ribosomal large subunit assembly
I6H81_RS04925	COG0200	Binds to the 23S rRNA
I6H81_RS04930	COG0201	protein transport
I6H81_RS04940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H81_RS04945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H81_RS04950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H81_RS04955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H81_RS04960	COG0202	RNA polymerase activity
I6H81_RS04965	COG0203	ribosomal protein L17
I6H81_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H81_RS04990	COG4232	protein-disulfide reductase activity
I6H81_RS04995	COG0113	porphobilinogen synthase activity
I6H81_RS05000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H81_RS05010	COG1333	cytochrome c biogenesis protein
I6H81_RS05015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H81_RS05030	COG5002	protein histidine kinase activity
I6H81_RS05030	COG5001	Diguanylate cyclase
I6H81_RS05050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H81_RS05055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H81_RS05060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6H81_RS05070	COG2814	Major facilitator Superfamily
I6H81_RS05080	COG2186	Transcriptional regulator
I6H81_RS05085	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H81_RS05090	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS05095	COG0251	oxidation-reduction process
I6H81_RS05100	COG2814	Major facilitator Superfamily
I6H81_RS05115	COG2814	Major facilitator Superfamily
I6H81_RS05125	COG1802	Transcriptional regulator
I6H81_RS05135	COG3069	C4-dicarboxylate transmembrane transporter activity
I6H81_RS05185	COG2423	ornithine cyclodeaminase activity
I6H81_RS05205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6H81_RS05210	COG2365	Tyrosine phosphatase family
I6H81_RS05230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H81_RS05230	COG1017	nitric oxide dioxygenase activity
I6H81_RS05240	COG0625	glutathione transferase activity
I6H81_RS05270	COG0789	Transcriptional regulator
I6H81_RS05280	COG2814	Major facilitator Superfamily
I6H81_RS05310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H81_RS05315	COG2986	histidine ammonia-lyase
I6H81_RS05335	COG1228	amidohydrolase
I6H81_RS05345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS05370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H81_RS05375	COG3568	Endonuclease Exonuclease Phosphatase
I6H81_RS05390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H81_RS05395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H81_RS05415	COG0109	protoheme IX farnesyltransferase activity
I6H81_RS05450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H81_RS05470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H81_RS05480	COG1522	sequence-specific DNA binding
I6H81_RS05490	COG1595	DNA-templated transcription, initiation
I6H81_RS05520	COG3284	Transcriptional regulator
I6H81_RS05530	COG2823	Periplasmic or secreted lipoprotein
I6H81_RS05550	COG1335	isochorismatase
I6H81_RS05555	COG1335	isochorismatase
I6H81_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS05570	COG0477	Major facilitator Superfamily
I6H81_RS05575	COG0583	DNA-binding transcription factor activity
I6H81_RS05580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6H81_RS05595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H81_RS05605	COG2226	methyltransferase
I6H81_RS05610	COG3706	GGDEF domain
I6H81_RS05615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H81_RS05625	COG0656	L-ascorbic acid biosynthetic process
I6H81_RS05630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6H81_RS05650	COG3483	tryptophan 2,3-dioxygenase activity
I6H81_RS05660	COG1522	sequence-specific DNA binding
I6H81_RS05665	COG1802	Transcriptional regulator
I6H81_RS05670	COG0129	dihydroxy-acid dehydratase activity
I6H81_RS05680	COG3622	Belongs to the hyi family
I6H81_RS05685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H81_RS05690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS05710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H81_RS05725	COG4150	thiosulfate binding
I6H81_RS05730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H81_RS05735	COG4208	sulfate ABC transporter
I6H81_RS05740	COG2969	positive regulation of protein catabolic process
I6H81_RS05745	COG0625	glutathione transferase activity
I6H81_RS05750	COG2857	Cytochrome c1
I6H81_RS05755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6H81_RS05760	COG0723	plastoquinol--plastocyanin reductase activity
I6H81_RS05765	COG1970	mechanosensitive ion channel activity
I6H81_RS05775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H81_RS05785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H81_RS05790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H81_RS05795	COG0537	adenosine 5'-monophosphoramidase activity
I6H81_RS05800	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H81_RS05810	COG0107	imidazoleglycerol-phosphate synthase activity
I6H81_RS05815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6H81_RS05825	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H81_RS05830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H81_RS05840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H81_RS05850	COG0842	Transport permease protein
I6H81_RS05855	COG1131	(ABC) transporter
I6H81_RS05870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H81_RS05875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H81_RS05880	COG1127	ABC transporter
I6H81_RS05895	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H81_RS05895	COG1024	Enoyl-CoA hydratase
I6H81_RS05900	COG0183	Belongs to the thiolase family
I6H81_RS05995	COG2885	chlorophyll binding
I6H81_RS06015	COG0697	spore germination
I6H81_RS06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS06025	COG0697	spore germination
I6H81_RS06030	COG2233	PERMEase
I6H81_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS06040	COG0604	alcohol dehydrogenase
I6H81_RS06040	COG3321	synthase
I6H81_RS06045	COG0156	8-amino-7-oxononanoate synthase activity
I6H81_RS06080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H81_RS06125	COG1215	transferase activity, transferring glycosyl groups
I6H81_RS06150	COG0166	Belongs to the GPI family
I6H81_RS06165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6H81_RS06180	COG4263	nitrous-oxide reductase activity
I6H81_RS06185	COG0348	domain, Protein
I6H81_RS06185	COG3901	Regulator of nitric oxide reductase transcription
I6H81_RS06190	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6H81_RS06195	COG0583	DNA-binding transcription factor activity
I6H81_RS06210	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H81_RS06230	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS06245	COG1476	TRANSCRIPTIONal
I6H81_RS06255	COG3276	selenocysteine insertion sequence binding
I6H81_RS06260	COG1921	L-seryl-tRNASec selenium transferase activity
I6H81_RS06270	COG2864	formate dehydrogenase
I6H81_RS06275	COG0437	4 iron, 4 sulfur cluster binding
I6H81_RS06305	COG1116	anion transmembrane transporter activity
I6H81_RS06325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H81_RS06330	COG0477	Major facilitator Superfamily
I6H81_RS06345	COG5002	protein histidine kinase activity
I6H81_RS06365	COG3180	Ammonia monooxygenase
I6H81_RS06390	COG4773	Receptor
I6H81_RS06395	COG2264	protein methyltransferase activity
I6H81_RS06400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H81_RS06440	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H81_RS06445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6H81_RS06450	COG0163	prenyltransferase activity
I6H81_RS06455	COG0037	tRNA processing
I6H81_RS06470	COG1024	Enoyl-CoA hydratase
I6H81_RS06480	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H81_RS06495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H81_RS06500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H81_RS06505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H81_RS06515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H81_RS06590	COG3039	Transposase
I6H81_RS06600	COG1216	Glycosyl transferase, family 2
I6H81_RS06605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H81_RS06615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H81_RS06615	COG2755	lipolytic protein G-D-S-L family
I6H81_RS06630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6H81_RS06645	COG3473	Maleate cis-trans isomerase
I6H81_RS06650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H81_RS06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H81_RS06680	COG2204	response regulator
I6H81_RS06695	COG0745	RESPONSE REGULATOR receiver
I6H81_RS06700	COG4771	TonB-dependent receptor
I6H81_RS06705	COG2226	methyltransferase
I6H81_RS06710	COG1040	competence protein
I6H81_RS06715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H81_RS06720	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS06725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H81_RS06730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6H81_RS06740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H81_RS06745	COG0588	phosphoglycerate mutase activity
I6H81_RS06755	COG0793	Belongs to the peptidase S41A family
I6H81_RS06760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H81_RS06780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H81_RS06795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6H81_RS06800	COG0792	nuclease activity
I6H81_RS06805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H81_RS06815	COG1660	Displays ATPase and GTPase activities
I6H81_RS06820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H81_RS06825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H81_RS06835	COG1137	ATPase activity
I6H81_RS06850	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6H81_RS06865	COG1271	oxidase subunit
I6H81_RS06870	COG1294	oxidase, subunit
I6H81_RS06880	COG4988	ABC transporter
I6H81_RS06885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H81_RS06920	COG1238	metal cluster binding
I6H81_RS06925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H81_RS06930	COG1984	allophanate hydrolase subunit 2
I6H81_RS06935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6H81_RS06950	COG0745	RESPONSE REGULATOR receiver
I6H81_RS06955	COG2226	methyltransferase
I6H81_RS06970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6H81_RS06980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H81_RS06985	COG1538	Outer membrane efflux protein
I6H81_RS06990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H81_RS06995	COG3344	reverse transcriptase
I6H81_RS07000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H81_RS07005	COG0351	phosphomethylpyrimidine kinase
I6H81_RS07010	COG2022	thiamine diphosphate biosynthetic process
I6H81_RS07025	COG0598	Magnesium transport protein CorA
I6H81_RS07045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS07055	COG1595	DNA-templated transcription, initiation
I6H81_RS07070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H81_RS07075	COG4206	TonB-dependent receptor
I6H81_RS07125	COG0259	pyridoxamine-phosphate oxidase activity
I6H81_RS07130	COG0477	Major facilitator Superfamily
I6H81_RS07140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H81_RS07145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H81_RS07160	COG0237	dephospho-CoA kinase activity
I6H81_RS07165	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6H81_RS07190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H81_RS07195	COG0494	nUDIX hydrolase
I6H81_RS07205	COG0142	geranyltranstransferase activity
I6H81_RS07210	COG0786	glutamate:sodium symporter activity
I6H81_RS07225	COG3604	Transcriptional regulator
I6H81_RS07240	COG3245	cytochrome
I6H81_RS07250	COG3384	dioxygenase
I6H81_RS07255	COG2259	Doxx family
I6H81_RS07260	COG0583	DNA-binding transcription factor activity
I6H81_RS07265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H81_RS07270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H81_RS07275	COG0154	amidase activity
I6H81_RS07280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H81_RS07285	COG1077	Cell shape determining protein MreB Mrl
I6H81_RS07290	COG1792	Involved in formation and maintenance of cell shape
I6H81_RS07300	COG0768	penicillin binding
I6H81_RS07305	COG0772	Belongs to the SEDS family
I6H81_RS07315	COG2177	Part of the ABC transporter FtsEX involved in
I6H81_RS07320	COG2884	Cell division ATP-binding protein ftsE
I6H81_RS07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS07330	COG4597	amino acid ABC transporter
I6H81_RS07335	COG0765	amino acid transport
I6H81_RS07340	COG1126	abc transporter atp-binding protein
I6H81_RS07360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H81_RS07385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H81_RS07390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H81_RS07395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H81_RS07400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H81_RS07405	COG3237	CsbD-like
I6H81_RS07415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H81_RS07430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H81_RS07435	COG0352	thiamine-phosphate diphosphorylase activity
I6H81_RS07450	COG1678	Uncharacterized ACR, COG1678
I6H81_RS07465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H81_RS07475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H81_RS07480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H81_RS07495	COG3150	esterase
I6H81_RS07500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H81_RS07505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H81_RS07510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H81_RS07515	COG0511	ligase activity, forming carbon-carbon bonds
I6H81_RS07520	COG0439	Biotin carboxylase
I6H81_RS07535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H81_RS07545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H81_RS07545	COG2169	Transcriptional regulator
I6H81_RS07555	COG0762	integral membrane protein
I6H81_RS07580	COG4681	YaeQ
I6H81_RS07585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H81_RS07590	COG4566	intracellular signal transduction
I6H81_RS07620	COG3028	Belongs to the UPF0307 family
I6H81_RS07625	COG0312	modulator of DNA gyrase
I6H81_RS07630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS07635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H81_RS07640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H81_RS07645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H81_RS07655	COG0316	Belongs to the HesB IscA family
I6H81_RS07660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6H81_RS07665	COG0739	heme binding
I6H81_RS07670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H81_RS07675	COG1881	PFAM PEBP family protein
I6H81_RS07680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H81_RS07685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H81_RS07690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H81_RS07690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H81_RS07705	COG0642	Histidine kinase
I6H81_RS07710	COG0745	RESPONSE REGULATOR receiver
I6H81_RS07715	COG0431	NADPH-dependent FMN reductase
I6H81_RS07720	COG1393	Belongs to the ArsC family
I6H81_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS07770	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6H81_RS07790	COG1024	Enoyl-CoA hydratase
I6H81_RS07800	COG0604	alcohol dehydrogenase
I6H81_RS07835	COG1877	trehalose-phosphatase activity
I6H81_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS07855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H81_RS07875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H81_RS07900	COG1054	Belongs to the UPF0176 family
I6H81_RS07910	COG1301	dicarboxylic acid transport
I6H81_RS07915	COG4191	Histidine kinase
I6H81_RS07920	COG2204	response regulator
I6H81_RS07945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6H81_RS07965	COG1388	LysM domain
I6H81_RS07965	COG0741	lytic transglycosylase activity
I6H81_RS07970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H81_RS07975	COG2226	methyltransferase
I6H81_RS07980	COG0328	RNA-DNA hybrid ribonuclease activity
I6H81_RS07985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H81_RS07990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H81_RS08005	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS08010	COG0402	S-adenosylhomocysteine deaminase activity
I6H81_RS08015	COG0583	DNA-binding transcription factor activity
I6H81_RS08020	COG2031	fatty acid transporter
I6H81_RS08025	COG4206	TonB-dependent receptor
I6H81_RS08035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H81_RS08040	COG1120	ATPase activity
I6H81_RS08055	COG0596	Alpha beta hydrolase
I6H81_RS08060	COG2309	aminopeptidase activity
I6H81_RS08065	COG1335	isochorismatase
I6H81_RS08100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS08125	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6H81_RS08130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H81_RS08140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS08145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H81_RS08145	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H81_RS08150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H81_RS08150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H81_RS08160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H81_RS08170	COG2188	Transcriptional regulator
I6H81_RS08175	COG1234	tRNA 3'-trailer cleavage
I6H81_RS08195	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS08235	COG0411	ABC transporter
I6H81_RS08240	COG0410	ABC transporter
I6H81_RS08250	COG2010	Cytochrome c
I6H81_RS08250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H81_RS08255	COG2080	2 iron, 2 sulfur cluster binding
I6H81_RS08260	COG2010	Cytochrome c
I6H81_RS08260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H81_RS08265	COG0596	Alpha beta hydrolase
I6H81_RS08270	COG2309	aminopeptidase activity
I6H81_RS08275	COG1335	isochorismatase
I6H81_RS08300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6H81_RS08330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H81_RS08335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H81_RS08340	COG0742	ribosomal rna small subunit methyltransferase
I6H81_RS08365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H81_RS08370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H81_RS08380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H81_RS08390	COG1414	Transcriptional regulator
I6H81_RS08405	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H81_RS08410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H81_RS08420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H81_RS08435	COG0154	amidase activity
I6H81_RS08440	COG3706	GGDEF domain
I6H81_RS08450	COG1741	Belongs to the pirin family
I6H81_RS08455	COG0583	DNA-binding transcription factor activity
I6H81_RS08470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H81_RS08480	COG5383	Protein conserved in bacteria
I6H81_RS08485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS08490	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS08510	COG0697	spore germination
I6H81_RS08525	COG3634	alkyl hydroperoxide reductase activity
I6H81_RS08535	COG0583	DNA-binding transcription factor activity
I6H81_RS08540	COG0427	acetyl-CoA hydrolase
I6H81_RS08560	COG3845	ABC transporter
I6H81_RS08565	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS08570	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS08595	COG0596	Alpha beta hydrolase
I6H81_RS08610	COG0823	Involved in the tonB-independent uptake of proteins
I6H81_RS08625	COG0811	peptide transport
I6H81_RS08630	COG0824	Thioesterase
I6H81_RS08635	COG0442	prolyl-tRNA aminoacylation
I6H81_RS08640	COG0494	nUDIX hydrolase
I6H81_RS08655	COG2084	Dehydrogenase
I6H81_RS08660	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H81_RS08665	COG3842	ATPase activity
I6H81_RS08670	COG1177	transmembrane transport
I6H81_RS08710	COG4654	Cytochrome c, class I
I6H81_RS08715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H81_RS08780	COG0415	Belongs to the DNA photolyase family
I6H81_RS08790	COG0418	dihydroorotase activity
I6H81_RS08800	COG2255	four-way junction helicase activity
I6H81_RS08810	COG0632	four-way junction helicase activity
I6H81_RS08815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H81_RS08825	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6H81_RS08835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H81_RS08860	COG0429	hydrolase of the alpha beta-hydrolase fold
I6H81_RS08880	COG0513	Belongs to the DEAD box helicase family
I6H81_RS08900	COG1414	Transcriptional regulator
I6H81_RS08915	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6H81_RS08920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6H81_RS08935	COG1846	Transcriptional regulator
I6H81_RS08940	COG1027	Aspartate ammonia-lyase
I6H81_RS08955	COG0516	GMP reductase activity
I6H81_RS08955	COG0517	IMP dehydrogenase activity
I6H81_RS09020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H81_RS09065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H81_RS09085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS09090	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H81_RS09135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H81_RS09145	COG0789	Transcriptional regulator
I6H81_RS09155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6H81_RS09160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H81_RS09175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H81_RS09190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H81_RS09195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H81_RS09200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6H81_RS09210	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6H81_RS09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H81_RS09225	COG0842	Transport permease protein
I6H81_RS09225	COG1129	ABC transporter
I6H81_RS09230	COG0842	Transport permease protein
I6H81_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS09265	COG2814	Major facilitator Superfamily
I6H81_RS09270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS09275	COG0154	amidase activity
I6H81_RS09290	COG2814	Major facilitator Superfamily
I6H81_RS09295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H81_RS09300	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6H81_RS09305	COG3971	2-oxopent-4-enoate hydratase activity
I6H81_RS09320	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H81_RS09335	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6H81_RS09340	COG4638	Rieske (2fe-2S)
I6H81_RS09345	COG0583	DNA-binding transcription factor activity
I6H81_RS09350	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H81_RS09355	COG3657	addiction module killer protein
I6H81_RS09360	COG0513	Belongs to the DEAD box helicase family
I6H81_RS09365	COG1414	Transcriptional regulator
I6H81_RS09390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H81_RS09400	COG1454	alcohol dehydrogenase
I6H81_RS09420	COG2819	hydrolase of the alpha beta superfamily
I6H81_RS09430	COG2814	Major facilitator Superfamily
I6H81_RS09455	COG2271	Major facilitator Superfamily
I6H81_RS09475	COG1538	Outer membrane efflux protein
I6H81_RS09505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H81_RS09515	COG3039	Transposase
I6H81_RS09525	COG3122	Protein conserved in bacteria
I6H81_RS09550	COG0477	Major facilitator Superfamily
I6H81_RS09575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H81_RS09580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H81_RS09585	COG0735	belongs to the Fur family
I6H81_RS09590	COG0497	DNA recombination
I6H81_RS09600	COG1420	regulation of RNA biosynthetic process
I6H81_RS09605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H81_RS09610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H81_RS09615	COG0443	Heat shock 70 kDa protein
I6H81_RS09620	COG0484	heat shock protein binding
I6H81_RS09625	COG0612	Peptidase, M16
I6H81_RS09685	COG4964	Belongs to the GSP D family
I6H81_RS09725	COG2204	response regulator
I6H81_RS09745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H81_RS09770	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS09775	COG2272	Belongs to the type-B carboxylesterase lipase family
I6H81_RS09795	COG0477	Major facilitator Superfamily
I6H81_RS09815	COG0492	ferredoxin-NADP+ reductase activity
I6H81_RS09820	COG1674	ftsk spoiiie
I6H81_RS09825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6H81_RS09830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H81_RS09835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H81_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS09900	COG3022	response to hydroperoxide
I6H81_RS09905	COG1289	transmembrane transporter activity
I6H81_RS09910	COG0028	Belongs to the TPP enzyme family
I6H81_RS09915	COG0440	acetolactate synthase activity
I6H81_RS09920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H81_RS09925	COG1183	phosphatidylcholine synthase activity
I6H81_RS09930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H81_RS09935	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H81_RS09960	COG0604	alcohol dehydrogenase
I6H81_RS09965	COG0149	triose-phosphate isomerase activity
I6H81_RS09980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS09985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H81_RS09990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H81_RS09995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H81_RS10000	COG0649	NAD binding
I6H81_RS10015	COG1034	ATP synthesis coupled electron transport
I6H81_RS10020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6H81_RS10025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H81_RS10035	COG0713	ATP synthesis coupled electron transport
I6H81_RS10050	COG1007	ATP synthesis coupled electron transport
I6H81_RS10065	COG0560	Phosphoserine phosphatase
I6H81_RS10070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H81_RS10075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H81_RS10080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H81_RS10095	COG1214	PFAM Peptidase M22, glycoprotease
I6H81_RS10100	COG1573	uracil-dna glycosylase
I6H81_RS10110	COG1196	nuclear chromosome segregation
I6H81_RS10120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H81_RS10125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H81_RS10135	COG2917	probably involved in intracellular septation
I6H81_RS10140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H81_RS10165	COG3047	cAMP biosynthetic process
I6H81_RS10170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H81_RS10175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H81_RS10180	COG2878	Part of a membrane complex involved in electron transport
I6H81_RS10190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6H81_RS10195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H81_RS10205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H81_RS10210	COG0133	tryptophan synthase activity
I6H81_RS10215	COG0159	tryptophan synthase activity
I6H81_RS10220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H81_RS10225	COG1530	ribonuclease E activity
I6H81_RS10230	COG0564	pseudouridine synthase activity
I6H81_RS10235	COG0546	phosphoglycolate phosphatase activity
I6H81_RS10240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6H81_RS10245	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H81_RS10250	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H81_RS10260	COG0424	maF-like protein
I6H81_RS10265	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H81_RS10270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H81_RS10280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H81_RS10285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H81_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS10295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H81_RS10300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H81_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H81_RS10335	COG0571	ribonuclease III activity
I6H81_RS10340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H81_RS10345	COG1381	Involved in DNA repair and RecF pathway recombination
I6H81_RS10360	COG1045	serine acetyltransferase
I6H81_RS10375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H81_RS10385	COG0583	DNA-binding transcription factor activity
I6H81_RS10395	COG0583	DNA-binding transcription factor activity
I6H81_RS10405	COG0791	NLP P60 protein
I6H81_RS10415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H81_RS10450	COG0504	CTP synthase activity
I6H81_RS10460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6H81_RS10475	COG2814	Major facilitator Superfamily
I6H81_RS10485	COG0148	phosphopyruvate hydratase activity
I6H81_RS10490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6H81_RS10500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H81_RS10515	COG1981	membrane
I6H81_RS10520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H81_RS10525	COG1466	dna polymerase III delta subunit
I6H81_RS10535	COG0495	leucyl-tRNA aminoacylation
I6H81_RS10540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H81_RS10545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H81_RS10550	COG2814	Major facilitator Superfamily
I6H81_RS10555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H81_RS10565	COG4176	ABC-type proline glycine betaine transport system permease component
I6H81_RS10570	COG4175	Glycine betaine
I6H81_RS10575	COG0534	Mate efflux family protein
I6H81_RS10590	COG2271	Major facilitator Superfamily
I6H81_RS10600	COG0477	Major facilitator Superfamily
I6H81_RS10605	COG1737	Transcriptional regulator
I6H81_RS10610	COG2003	Belongs to the UPF0758 family
I6H81_RS10615	COG1047	Peptidyl-prolyl cis-trans
I6H81_RS10620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H81_RS10625	COG0625	glutathione transferase activity
I6H81_RS10630	COG2084	Dehydrogenase
I6H81_RS10640	COG0023	Translation Initiation Factor
I6H81_RS10660	COG0424	maF-like protein
I6H81_RS10665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6H81_RS10670	COG0799	negative regulation of ribosome biogenesis
I6H81_RS10675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H81_RS10685	COG0151	Belongs to the GarS family
I6H81_RS10690	COG0217	transcriptional regulatory protein
I6H81_RS10695	COG0433	COG0433 Predicted ATPase
I6H81_RS10705	COG0473	3-isopropylmalate dehydrogenase activity
I6H81_RS10720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6H81_RS10725	COG0308	aminopeptidase N
I6H81_RS10740	COG0312	modulator of DNA gyrase
I6H81_RS10750	COG1846	Transcriptional regulator
I6H81_RS10755	COG0456	acetyltransferase
I6H81_RS10765	COG0662	Cupin 2, conserved barrel domain protein
I6H81_RS10770	COG5285	phytanoyl-CoA dioxygenase
I6H81_RS10785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS10800	COG1116	anion transmembrane transporter activity
I6H81_RS10805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H81_RS10810	COG2226	methyltransferase
I6H81_RS10810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H81_RS10810	COG0596	Alpha beta hydrolase
I6H81_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS10820	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6H81_RS10825	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS10830	COG0028	Belongs to the TPP enzyme family
I6H81_RS10835	COG1126	abc transporter atp-binding protein
I6H81_RS10840	COG0765	amino acid transport
I6H81_RS10845	COG0765	amino acid transport
I6H81_RS10850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS10855	COG1966	Carbon starvation protein
I6H81_RS10860	COG2879	small protein
I6H81_RS10865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H81_RS10870	COG0277	FAD linked oxidase domain protein
I6H81_RS10875	COG0482	sulfurtransferase activity
I6H81_RS10880	COG0730	response to heat
I6H81_RS10885	COG0625	glutathione transferase activity
I6H81_RS10895	COG3909	cytochrome
I6H81_RS10900	COG0004	ammonium transporteR
I6H81_RS10905	COG0347	Belongs to the P(II) protein family
I6H81_RS10910	COG1846	Transcriptional regulator
I6H81_RS10915	COG2175	clavaminate synthase activity
I6H81_RS10920	COG2271	Major facilitator Superfamily
I6H81_RS10930	COG2321	neutral zinc metallopeptidase
I6H81_RS10935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6H81_RS10950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H81_RS10955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H81_RS10970	COG2119	membrane
I6H81_RS10975	COG0840	transmembrane signaling receptor activity
I6H81_RS10985	COG0642	Histidine kinase
I6H81_RS10990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H81_RS10995	COG2046	Belongs to the sulfate adenylyltransferase family
I6H81_RS11000	COG2205	protein histidine kinase activity
I6H81_RS11000	COG2198	Histidine kinase
I6H81_RS11000	COG0784	Response regulator, receiver
I6H81_RS11010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H81_RS11030	COG1280	lysine exporter protein (LysE YggA)
I6H81_RS11035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H81_RS11045	COG0625	glutathione transferase activity
I6H81_RS11100	COG1309	transcriptional regulator
I6H81_RS11105	COG0251	oxidation-reduction process
I6H81_RS11115	COG0436	Aminotransferase
I6H81_RS11125	COG4335	DNA alkylation repair
I6H81_RS11135	COG0753	catalase activity
I6H81_RS11150	COG4771	TonB-dependent receptor
I6H81_RS11160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6H81_RS11180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6H81_RS11195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H81_RS11205	COG0287	Prephenate dehydrogenase
I6H81_RS11210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H81_RS11215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H81_RS11235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6H81_RS11240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6H81_RS11245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H81_RS11250	COG1596	polysaccharide export
I6H81_RS11250	COG1555	photosystem II stabilization
I6H81_RS11260	COG2951	lytic endotransglycosylase activity
I6H81_RS11265	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6H81_RS11280	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS11285	COG0450	alkyl hydroperoxide reductase
I6H81_RS11305	COG0335	large ribosomal subunit rRNA binding
I6H81_RS11315	COG1162	GTPase activity
I6H81_RS11320	COG0501	Belongs to the peptidase M48B family
I6H81_RS11325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H81_RS11330	COG3396	Phenylacetate-CoA oxygenase
I6H81_RS11335	COG3460	Phenylacetate-CoA oxygenase
I6H81_RS11340	COG3396	Phenylacetate-CoA oxygenase
I6H81_RS11345	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H81_RS11350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H81_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS11360	COG1024	Enoyl-CoA hydratase
I6H81_RS11365	COG2050	protein possibly involved in aromatic compounds catabolism
I6H81_RS11375	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H81_RS11380	COG1472	Belongs to the glycosyl hydrolase 3 family
I6H81_RS11400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H81_RS11400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H81_RS11405	COG2224	Isocitrate lyase
I6H81_RS11410	COG2217	Heavy metal translocating P-type atpase
I6H81_RS11420	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H81_RS11440	COG0348	domain, Protein
I6H81_RS11455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H81_RS11460	COG0542	response to heat
I6H81_RS11465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H81_RS11470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H81_RS11500	COG0601	transmembrane transport
I6H81_RS11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H81_RS11530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H81_RS11535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H81_RS11560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS11595	COG2351	hydroxyisourate hydrolase activity
I6H81_RS11610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H81_RS11615	COG0425	Belongs to the sulfur carrier protein TusA family
I6H81_RS11620	COG0228	four-way junction DNA binding
I6H81_RS11630	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H81_RS11640	COG0105	UTP biosynthetic process
I6H81_RS11645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H81_RS11665	COG2976	Protein conserved in bacteria
I6H81_RS11670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H81_RS11675	COG1160	GTP binding
I6H81_RS11685	COG1923	regulation of RNA biosynthetic process
I6H81_RS11690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H81_RS11695	COG0330	HflC and HflK could
I6H81_RS11700	COG0330	HflC and HflK could
I6H81_RS11710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H81_RS11715	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6H81_RS11720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H81_RS11735	COG2205	protein histidine kinase activity
I6H81_RS11740	COG0745	RESPONSE REGULATOR receiver
I6H81_RS11750	COG0402	S-adenosylhomocysteine deaminase activity
I6H81_RS11760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H81_RS11785	COG3135	benzoate transporter
I6H81_RS11790	COG2207	Transcriptional regulator
I6H81_RS11795	COG2807	transmembrane transport
I6H81_RS11800	COG2814	Major facilitator Superfamily
I6H81_RS11805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H81_RS11815	COG1741	Belongs to the pirin family
I6H81_RS11820	COG0625	glutathione transferase activity
I6H81_RS11825	COG3530	Putative quorum-sensing-regulated virulence factor
I6H81_RS11830	COG0412	Dienelactone hydrolase
I6H81_RS11850	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H81_RS11855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H81_RS11860	COG1175	transmembrane transport
I6H81_RS11865	COG3842	ATPase activity
I6H81_RS11870	COG0583	DNA-binding transcription factor activity
I6H81_RS11900	COG2375	cellular response to nickel ion
I6H81_RS11920	COG1850	ribulose-bisphosphate carboxylase activity
I6H81_RS11935	COG1126	abc transporter atp-binding protein
I6H81_RS11940	COG0765	amino acid transport
I6H81_RS11945	COG0765	amino acid transport
I6H81_RS11965	COG0557	exoribonuclease II activity
I6H81_RS11970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H81_RS11975	COG0626	cystathionine gamma-synthase activity
I6H81_RS11980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H81_RS11985	COG2010	Cytochrome c
I6H81_RS11995	COG1648	precorrin-2 dehydrogenase activity
I6H81_RS11995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H81_RS12000	COG0535	radical SAM domain protein
I6H81_RS12020	COG3391	amine dehydrogenase activity
I6H81_RS12030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H81_RS12030	COG1648	precorrin-2 dehydrogenase activity
I6H81_RS12135	COG1396	sequence-specific DNA binding
I6H81_RS12230	COG0740	serine-type endopeptidase activity
I6H81_RS12340	COG1278	Cold shock
I6H81_RS12355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6H81_RS12360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H81_RS12365	COG4208	sulfate ABC transporter
I6H81_RS12370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H81_RS12395	COG0642	Histidine kinase
I6H81_RS12400	COG3158	transport of potassium into the cell
I6H81_RS12425	COG0477	Major facilitator Superfamily
I6H81_RS12440	COG2212	antiporter activity
I6H81_RS12450	COG0651	ATP synthesis coupled electron transport
I6H81_RS12455	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H81_RS12460	COG2111	Na H antiporter
I6H81_RS12460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H81_RS12470	COG2070	2-Nitropropane dioxygenase
I6H81_RS12485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H81_RS12500	COG0540	Belongs to the ATCase OTCase family
I6H81_RS12515	COG3162	membrane
I6H81_RS12520	COG1024	Enoyl-CoA hydratase
I6H81_RS12525	COG0318	PFAM AMP-dependent synthetase and ligase
I6H81_RS12540	COG0477	Major facilitator Superfamily
I6H81_RS12555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H81_RS12560	COG2137	regulation of response to DNA damage stimulus
I6H81_RS12565	COG0583	DNA-binding transcription factor activity
I6H81_RS12570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H81_RS12580	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H81_RS12585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6H81_RS12590	COG0861	Integral membrane protein TerC family
I6H81_RS12595	COG0181	hydroxymethylbilane synthase activity
I6H81_RS12605	COG2959	enzyme of heme biosynthesis
I6H81_RS12650	COG4964	Belongs to the GSP D family
I6H81_RS12685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H81_RS12695	COG1295	ribonuclease BN
I6H81_RS12705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H81_RS12710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H81_RS12725	COG4566	intracellular signal transduction
I6H81_RS12735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H81_RS12760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H81_RS12770	COG0101	tRNA pseudouridine synthase activity
I6H81_RS12780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS12785	COG0135	phosphoribosylanthranilate isomerase activity
I6H81_RS12790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H81_RS12800	COG2207	Transcriptional regulator
I6H81_RS12805	COG0519	Catalyzes the synthesis of GMP from XMP
I6H81_RS12805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H81_RS12810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H81_RS12815	COG0318	PFAM AMP-dependent synthetase and ligase
I6H81_RS12820	COG1666	GTP binding
I6H81_RS12830	COG0842	Transport permease protein
I6H81_RS12835	COG1131	(ABC) transporter
I6H81_RS12840	COG0590	tRNA wobble adenosine to inosine editing
I6H81_RS12845	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H81_RS12850	COG0488	(ABC) transporter
I6H81_RS12870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H81_RS12875	COG2252	PERMEase
I6H81_RS12880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H81_RS12885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H81_RS12890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6H81_RS12895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H81_RS12905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H81_RS12915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS12930	COG0165	Argininosuccinate lyase
I6H81_RS12935	COG0668	transmembrane transport
I6H81_RS12945	COG0656	L-ascorbic acid biosynthetic process
I6H81_RS12950	COG2814	Major facilitator Superfamily
I6H81_RS12955	COG3161	chorismate lyase activity
I6H81_RS12960	COG1187	pseudouridine synthase activity
I6H81_RS12965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H81_RS12970	COG0584	glycerophosphoryl diester phosphodiesterase
I6H81_RS12975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H81_RS12980	COG0739	heme binding
I6H81_RS12985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H81_RS12995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H81_RS13000	COG1758	RNA polymerase activity
I6H81_RS13005	COG0194	GDP metabolic process
I6H81_RS13040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6H81_RS13050	COG0183	Belongs to the thiolase family
I6H81_RS13075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6H81_RS13080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H81_RS13085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H81_RS13095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6H81_RS13115	COG0183	Belongs to the thiolase family
I6H81_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS13145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H81_RS13150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS13155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H81_RS13160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS13175	COG0640	Transcriptional regulator
I6H81_RS13185	COG1999	signal sequence binding
I6H81_RS13195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H81_RS13210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H81_RS13215	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H81_RS13220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H81_RS13225	COG0285	dihydrofolate synthase activity
I6H81_RS13235	COG1286	toxin biosynthetic process
I6H81_RS13260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6H81_RS13265	COG0024	Methionine aminopeptidase
I6H81_RS13270	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H81_RS13275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H81_RS13280	COG0528	UMP kinase activity
I6H81_RS13285	COG0233	cytoplasmic translational termination
I6H81_RS13290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H81_RS13295	COG0575	Belongs to the CDS family
I6H81_RS13300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H81_RS13310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H81_RS13320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H81_RS13325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H81_RS13335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H81_RS13340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H81_RS13345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H81_RS13370	COG1252	NADH dehydrogenase
I6H81_RS13375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H81_RS13380	COG2867	negative regulation of translational initiation
I6H81_RS13385	COG2914	Belongs to the UPF0125 (RnfH) family
I6H81_RS13390	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS13410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H81_RS13420	COG0470	DNA polymerase III
I6H81_RS13425	COG0084	hydrolase, TatD family'
I6H81_RS13445	COG0625	glutathione transferase activity
I6H81_RS13450	COG1393	Belongs to the ArsC family
I6H81_RS13455	COG2353	YceI-like domain
I6H81_RS13465	COG3038	cytochrome b561
I6H81_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS13510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6H81_RS13515	COG2132	Multicopper oxidase
I6H81_RS13525	COG4974	Belongs to the 'phage' integrase family
I6H81_RS13530	COG0583	DNA-binding transcription factor activity
I6H81_RS13560	COG0583	DNA-binding transcription factor activity
I6H81_RS13570	COG2807	transmembrane transport
I6H81_RS13575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H81_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS13590	COG0235	Class ii aldolase
I6H81_RS13595	COG2207	Transcriptional regulator
I6H81_RS13600	COG4654	Cytochrome c, class I
I6H81_RS13605	COG0589	response to stress
I6H81_RS13610	COG2226	methyltransferase
I6H81_RS13615	COG2133	pyrroloquinoline quinone binding
I6H81_RS13620	COG0114	fumarate hydratase activity
I6H81_RS13625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H81_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS13635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H81_RS13645	COG0625	glutathione transferase activity
I6H81_RS13665	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H81_RS13680	COG1653	transport
I6H81_RS13685	COG1175	transmembrane transport
I6H81_RS13690	COG0395	ABC-type sugar transport system, permease component
I6H81_RS13695	COG3842	ATPase activity
I6H81_RS13705	COG0783	Belongs to the Dps family
I6H81_RS13715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H81_RS13730	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H81_RS13735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H81_RS13740	COG3842	ATPase activity
I6H81_RS13760	COG2153	protein acetylation
I6H81_RS13765	COG0174	glutamine synthetase
I6H81_RS13770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H81_RS13775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H81_RS13780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6H81_RS13795	COG1561	YicC-like family, N-terminal region
I6H81_RS13800	COG2816	NAD+ diphosphatase activity
I6H81_RS13830	COG2814	Major facilitator Superfamily
I6H81_RS13840	COG1473	amidohydrolase
I6H81_RS13845	COG0071	Belongs to the small heat shock protein (HSP20) family
I6H81_RS13850	COG2233	PERMEase
I6H81_RS13895	COG4191	Histidine kinase
I6H81_RS13900	COG1301	dicarboxylic acid transport
I6H81_RS13915	COG0307	riboflavin synthase, alpha
I6H81_RS13925	COG4221	oxidoreductase activity
I6H81_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS13945	COG1360	Flagellar Motor Protein
I6H81_RS13960	COG1686	Belongs to the peptidase S11 family
I6H81_RS13965	COG0583	DNA-binding transcription factor activity
I6H81_RS13970	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS14005	COG0587	DNA-directed DNA polymerase activity
I6H81_RS14010	COG1610	YqeY-like protein
I6H81_RS14020	COG1902	pentaerythritol trinitrate reductase activity
I6H81_RS14025	COG0569	domain protein
I6H81_RS14030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H81_RS14045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H81_RS14060	COG3949	Membrane
I6H81_RS14075	COG3258	Cytochrome c
I6H81_RS14080	COG3048	D-serine ammonia-lyase activity
I6H81_RS14130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H81_RS14145	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H81_RS14150	COG0822	iron-sulfur transferase activity
I6H81_RS14160	COG0719	Fe-S assembly protein
I6H81_RS14165	COG0396	ATPase activity
I6H81_RS14170	COG0719	Fe-S assembly protein
I6H81_RS14175	COG1959	2 iron, 2 sulfur cluster binding
I6H81_RS14180	COG5265	(ABC) transporter
I6H81_RS14195	COG2833	Protein of unknown function (DUF455)
I6H81_RS14210	COG0072	phenylalanine-tRNA ligase activity
I6H81_RS14210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H81_RS14215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H81_RS14220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H81_RS14225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H81_RS14255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H81_RS14260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H81_RS14275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H81_RS14280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H81_RS14300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H81_RS14310	COG3042	response to heat
I6H81_RS14320	COG2226	methyltransferase
I6H81_RS14325	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6H81_RS14330	COG0330	HflC and HflK could
I6H81_RS14355	COG0402	S-adenosylhomocysteine deaminase activity
I6H81_RS14375	COG1280	lysine exporter protein (LysE YggA)
I6H81_RS14380	COG2814	Major facilitator Superfamily
I6H81_RS14410	COG2871	sodium ion transport
I6H81_RS14460	COG1126	abc transporter atp-binding protein
I6H81_RS14465	COG0765	amino acid transport
I6H81_RS14470	COG0765	amino acid transport
I6H81_RS14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H81_RS14495	COG3422	double-strand break repair
I6H81_RS14500	COG1272	protein, Hemolysin III
I6H81_RS14520	COG2135	peptidase activity
I6H81_RS14530	COG1335	isochorismatase
I6H81_RS14535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6H81_RS14610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H81_RS14835	COG0629	single-stranded DNA binding
I6H81_RS14880	COG0582	viral genome integration into host DNA
I6H81_RS14895	COG0667	Aldo Keto reductase
I6H81_RS14900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H81_RS14925	COG0697	spore germination
I6H81_RS14935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H81_RS14945	COG2271	Major facilitator Superfamily
I6H81_RS14950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H81_RS14955	COG1846	Transcriptional regulator
I6H81_RS14980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H81_RS14985	COG2197	response regulator
I6H81_RS14995	COG4555	ABC transporter
I6H81_RS15010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6H81_RS15015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H81_RS15020	COG3135	benzoate transporter
I6H81_RS15030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H81_RS15035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H81_RS15045	COG3485	protocatechuate 3,4-dioxygenase
I6H81_RS15075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H81_RS15100	COG0640	Transcriptional regulator
I6H81_RS15125	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS15135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS15185	COG0740	serine-type endopeptidase activity
I6H81_RS15190	COG0625	glutathione transferase activity
I6H81_RS15210	COG0583	DNA-binding transcription factor activity
I6H81_RS15215	COG0625	glutathione transferase activity
I6H81_RS15230	COG1309	transcriptional regulator
I6H81_RS15255	COG2070	2-Nitropropane dioxygenase
I6H81_RS15265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H81_RS15270	COG3162	membrane
I6H81_RS15285	COG1942	4-Oxalocrotonate Tautomerase
I6H81_RS15295	COG1566	PFAM secretion protein HlyD family protein
I6H81_RS15305	COG1289	transmembrane transporter activity
I6H81_RS15310	COG0583	DNA-binding transcription factor activity
I6H81_RS15330	COG2207	Transcriptional regulator
I6H81_RS15335	COG0745	RESPONSE REGULATOR receiver
I6H81_RS15355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H81_RS15360	COG0735	belongs to the Fur family
I6H81_RS15365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H81_RS15375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H81_RS15380	COG1469	GTP cyclohydrolase I activity
I6H81_RS15385	COG0523	cobalamin synthesis protein
I6H81_RS15390	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS15400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H81_RS15415	COG0583	DNA-binding transcription factor activity
I6H81_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS15425	COG2076	Multidrug Resistance protein
I6H81_RS15440	COG3311	Transcriptional regulator
I6H81_RS15450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H81_RS15455	COG0519	Catalyzes the synthesis of GMP from XMP
I6H81_RS15455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H81_RS15480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H81_RS15480	COG0047	phosphoribosylformylglycinamidine synthase activity
I6H81_RS15490	COG0613	PHP domain protein
I6H81_RS15505	COG0084	hydrolase, TatD family'
I6H81_RS15510	COG1136	(ABC) transporter
I6H81_RS15525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H81_RS15535	COG0385	Bile acid
I6H81_RS15540	COG0697	spore germination
I6H81_RS15545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H81_RS15550	COG0840	transmembrane signaling receptor activity
I6H81_RS15560	COG4221	oxidoreductase activity
I6H81_RS15565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H81_RS15580	COG0316	Belongs to the HesB IscA family
I6H81_RS15590	COG1104	cysteine desulfurase activity
I6H81_RS15600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H81_RS15605	COG0556	nucleotide-excision repair
I6H81_RS15615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H81_RS15625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H81_RS15635	COG0740	serine-type endopeptidase activity
I6H81_RS15640	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H81_RS15645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H81_RS15665	COG0789	Transcriptional regulator
I6H81_RS15710	COG0471	metal ion transport
I6H81_RS15710	COG3273	potassium ion transport
I6H81_RS15720	COG2207	Transcriptional regulator
I6H81_RS15730	COG2171	N-acyltransferase activity
I6H81_RS15735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H81_RS15740	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H81_RS15745	COG0488	(ABC) transporter
I6H81_RS15800	COG0210	DNA helicase
I6H81_RS15810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H81_RS15810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H81_RS15815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H81_RS15820	COG0196	riboflavin kinase activity
I6H81_RS15825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H81_RS15830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H81_RS15840	COG0756	dUTP diphosphatase activity
I6H81_RS15845	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6H81_RS15850	COG0693	protein deglycase activity
I6H81_RS15900	COG3008	intermembrane lipid transfer
I6H81_RS15900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H81_RS15905	COG2995	paraquat-inducible protein a
I6H81_RS15910	COG0542	response to heat
I6H81_RS15915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H81_RS15920	COG1278	Cold shock
I6H81_RS15930	COG0183	Belongs to the thiolase family
I6H81_RS15940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H81_RS15945	COG1570	exodeoxyribonuclease VII activity
I6H81_RS15950	COG0811	peptide transport
I6H81_RS15955	COG0848	biopolymer transport protein
I6H81_RS15965	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H81_RS15970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6H81_RS15975	COG0563	adenylate kinase activity
I6H81_RS15985	COG0728	peptidoglycan biosynthetic process
I6H81_RS15990	COG0268	Binds directly to 16S ribosomal RNA
I6H81_RS15995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H81_RS16005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H81_RS16010	COG0745	RESPONSE REGULATOR receiver
I6H81_RS16015	COG2205	protein histidine kinase activity
I6H81_RS16020	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6H81_RS16030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6H81_RS16040	COG1609	Transcriptional regulator
I6H81_RS16060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H81_RS16065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H81_RS16070	COG0137	argininosuccinate synthase activity
I6H81_RS16080	COG2832	Protein of unknown function (DUF454)
I6H81_RS16085	COG0494	nUDIX hydrolase
I6H81_RS16095	COG0626	cystathionine gamma-synthase activity
I6H81_RS16100	COG1522	sequence-specific DNA binding
I6H81_RS16115	COG3706	GGDEF domain
I6H81_RS16175	COG2814	Major facilitator Superfamily
I6H81_RS16180	COG0501	Belongs to the peptidase M48B family
I6H81_RS16190	COG0456	acetyltransferase
I6H81_RS16205	COG1490	D-aminoacyl-tRNA deacylase activity
I6H81_RS16210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H81_RS16220	COG2239	Acts as a magnesium transporter
I6H81_RS16225	COG0784	Response regulator, receiver
I6H81_RS16225	COG2198	Histidine kinase
I6H81_RS16225	COG2205	protein histidine kinase activity
I6H81_RS16230	COG3437	response regulator, receiver
I6H81_RS16235	COG1396	sequence-specific DNA binding
I6H81_RS16250	COG0477	Major facilitator Superfamily
I6H81_RS16255	COG3264	Mechanosensitive ion channel
I6H81_RS16255	COG1511	domain protein
I6H81_RS16260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H81_RS16260	COG3264	Mechanosensitive ion channel
I6H81_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS16310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H81_RS16320	COG1846	Transcriptional regulator
I6H81_RS16330	COG0069	glutamate synthase activity
I6H81_RS16340	COG1999	signal sequence binding
I6H81_RS16360	COG2252	PERMEase
I6H81_RS16365	COG1289	transmembrane transporter activity
I6H81_RS16380	COG0025	NhaP-type Na H and K H
I6H81_RS16435	COG3258	Cytochrome c
I6H81_RS16440	COG2863	cytochrome
I6H81_RS16450	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H81_RS16460	COG0642	Histidine kinase
I6H81_RS16465	COG1278	Cold shock
I6H81_RS16490	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H81_RS16525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H81_RS16530	COG3755	Protein conserved in bacteria
I6H81_RS16535	COG0583	DNA-binding transcription factor activity
I6H81_RS16555	COG1113	amino acid transport
I6H81_RS16565	COG1192	Involved in chromosome partitioning
I6H81_RS16595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS16605	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H81_RS16610	COG0583	DNA-binding transcription factor activity
I6H81_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS16620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H81_RS16625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6H81_RS16630	COG4521	taurine ABC transporter
I6H81_RS16635	COG1538	Outer membrane efflux protein
I6H81_RS16680	COG4128	Pfam Zonular occludens toxin
I6H81_RS16740	COG4974	Belongs to the 'phage' integrase family
I6H81_RS16765	COG2610	gluconate transmembrane transporter activity
I6H81_RS16790	COG0840	transmembrane signaling receptor activity
I6H81_RS16795	COG0840	transmembrane signaling receptor activity
I6H81_RS16800	COG2733	membrane
I6H81_RS16820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H81_RS16890	COG0582	viral genome integration into host DNA
I6H81_RS16915	COG1191	sigma factor activity
I6H81_RS16920	COG1334	flagellar protein FlaG
I6H81_RS16945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H81_RS16950	COG1677	Flagellar hook-basal body complex protein FliE
I6H81_RS16955	COG1766	The M ring may be actively involved in energy transduction
I6H81_RS16970	COG1157	protein secretion by the type III secretion system
I6H81_RS16995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6H81_RS17010	COG1987	bacterial-type flagellum assembly
I6H81_RS17020	COG2176	DNA-directed DNA polymerase activity
I6H81_RS17045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6H81_RS17085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6H81_RS17090	COG1558	bacterial-type flagellum-dependent cell motility
I6H81_RS17095	COG1815	bacterial-type flagellum-dependent cell motility
I6H81_RS17120	COG3550	peptidyl-serine autophosphorylation
I6H81_RS17130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H81_RS17140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6H81_RS17145	COG0745	RESPONSE REGULATOR receiver
I6H81_RS17155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6H81_RS17160	COG0840	transmembrane signaling receptor activity
I6H81_RS17165	COG0835	chemotaxis
I6H81_RS17175	COG1360	Flagellar Motor Protein
I6H81_RS17195	COG0791	NLP P60 protein
I6H81_RS17200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H81_RS17205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H81_RS17210	COG2314	TM2 domain
I6H81_RS17220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H81_RS17225	COG0659	secondary active sulfate transmembrane transporter activity
I6H81_RS17250	COG0640	Transcriptional regulator
I6H81_RS17260	COG3094	Invasion gene expression up-regulator, SirB
I6H81_RS17280	COG0697	spore germination
I6H81_RS17290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H81_RS17305	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H81_RS17310	COG0628	permease
I6H81_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS17360	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS17385	COG0247	lactate metabolic process
I6H81_RS17390	COG0277	FAD linked oxidase domain protein
I6H81_RS17395	COG0277	FAD linked oxidase domain protein
I6H81_RS17400	COG2186	Transcriptional regulator
I6H81_RS17450	COG1132	(ABC) transporter
I6H81_RS17475	COG0438	transferase activity, transferring glycosyl groups
I6H81_RS17490	COG0726	polysaccharide deacetylase
I6H81_RS17495	COG0438	transferase activity, transferring glycosyl groups
I6H81_RS17505	COG1643	Atp-dependent helicase
I6H81_RS17510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6H81_RS17510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H81_RS17515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6H81_RS17520	COG0659	secondary active sulfate transmembrane transporter activity
I6H81_RS17525	COG4251	negative regulation of phosphorylation
I6H81_RS17525	COG3706	GGDEF domain
I6H81_RS17525	COG2203	Gaf domain
I6H81_RS17525	COG5001	Diguanylate cyclase
I6H81_RS17530	COG0704	Plays a role in the regulation of phosphate uptake
I6H81_RS17535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H81_RS17540	COG1393	Belongs to the ArsC family
I6H81_RS17545	COG1177	transmembrane transport
I6H81_RS17550	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H81_RS17555	COG3842	ATPase activity
I6H81_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS17585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H81_RS17590	COG1562	ergosterol biosynthetic process
I6H81_RS17595	COG1562	ergosterol biosynthetic process
I6H81_RS17600	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6H81_RS17605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H81_RS17620	COG0436	Aminotransferase
I6H81_RS17630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H81_RS17635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6H81_RS17640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6H81_RS17650	COG0305	Participates in initiation and elongation during chromosome replication
I6H81_RS17660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H81_RS17665	COG2965	DNA replication, synthesis of RNA primer
I6H81_RS17670	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H81_RS17675	COG1469	GTP cyclohydrolase I activity
I6H81_RS17685	COG0142	geranyltranstransferase activity
I6H81_RS17690	COG1722	exodeoxyribonuclease VII activity
I6H81_RS17705	COG0501	Belongs to the peptidase M48B family
I6H81_RS17720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H81_RS17730	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H81_RS17750	COG4215	(ABC) transporter
I6H81_RS17755	COG4160	amino acid transport
I6H81_RS17765	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H81_RS17770	COG1217	gtp-binding protein TYPA
I6H81_RS17775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H81_RS17780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H81_RS17790	COG0195	Participates in both transcription termination and antitermination
I6H81_RS17790	COG2251	uridine kinase activity
I6H81_RS17795	COG0779	Required for maturation of 30S ribosomal subunits
I6H81_RS17800	COG1187	pseudouridine synthase activity
I6H81_RS17805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H81_RS17830	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6H81_RS17835	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS17840	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6H81_RS17850	COG0564	pseudouridine synthase activity
I6H81_RS17865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H81_RS17865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H81_RS17875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H81_RS17880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H81_RS17880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H81_RS17895	COG1733	regulation of RNA biosynthetic process
I6H81_RS17905	COG1199	ATP-dependent helicase activity
I6H81_RS17910	COG2183	response to ionizing radiation
I6H81_RS17930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6H81_RS17935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H81_RS17940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H81_RS17945	COG0567	Dehydrogenase, E1 component
I6H81_RS17950	COG0281	malic enzyme
I6H81_RS17950	COG0280	phosphate acetyltransferase
I6H81_RS17955	COG1620	l-lactate permease
I6H81_RS17960	COG2186	Transcriptional regulator
I6H81_RS17965	COG0372	Belongs to the citrate synthase family
I6H81_RS17970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6H81_RS17975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H81_RS17980	COG1053	succinate dehydrogenase
I6H81_RS17990	COG2009	succinate dehydrogenase
I6H81_RS17995	COG2188	Transcriptional regulator
I6H81_RS18000	COG0039	L-malate dehydrogenase activity
I6H81_RS18010	COG0477	Major facilitator Superfamily
I6H81_RS18015	COG3829	transcription factor binding
I6H81_RS18045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H81_RS18070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H81_RS18075	COG1454	alcohol dehydrogenase
I6H81_RS18080	COG1012	belongs to the aldehyde dehydrogenase family
I6H81_RS18085	COG3284	Transcriptional regulator
I6H81_RS18095	COG4172	Belongs to the ABC transporter superfamily
I6H81_RS18100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H81_RS18110	COG0747	negative chemotaxis
I6H81_RS18120	COG1960	acyl-CoA dehydrogenase activity
I6H81_RS18125	COG0598	Magnesium transport protein CorA
I6H81_RS18130	COG2363	Small membrane protein
I6H81_RS18135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H81_RS18155	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6H81_RS18160	COG0435	Glutathione S-transferase
I6H81_RS18165	COG1304	FMN binding
I6H81_RS18195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6H81_RS18205	COG3842	ATPase activity
I6H81_RS18210	COG4208	sulfate ABC transporter
I6H81_RS18230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H81_RS18245	COG0330	HflC and HflK could
I6H81_RS18270	COG0037	tRNA processing
I6H81_RS18275	COG0825	malonyl-CoA metabolic process
I6H81_RS18285	COG0215	cysteine-tRNA ligase activity
I6H81_RS18305	COG1968	undecaprenyl-diphosphatase activity
I6H81_RS18310	COG1253	flavin adenine dinucleotide binding
I6H81_RS18315	COG0483	inositol monophosphate 1-phosphatase activity
I6H81_RS18330	COG2031	fatty acid transporter
I6H81_RS18335	COG0154	amidase activity
I6H81_RS18370	COG3321	synthase
I6H81_RS18370	COG1028	Short-chain dehydrogenase reductase Sdr
I6H81_RS18370	COG0604	alcohol dehydrogenase
I6H81_RS18380	COG0668	transmembrane transport
I6H81_RS18390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H81_RS18400	COG3181	Tripartite tricarboxylate transporter family receptor
I6H81_RS18410	COG1132	(ABC) transporter
I6H81_RS18415	COG0363	glucosamine-6-phosphate deaminase activity
I6H81_RS18420	COG1538	Outer membrane efflux protein
I6H81_RS18425	COG1136	(ABC) transporter
I6H81_RS18425	COG0577	efflux transmembrane transporter activity
I6H81_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H81_RS18440	COG3391	amine dehydrogenase activity
I6H81_RS18445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H81_RS18450	COG2850	peptidyl-arginine hydroxylation
I6H81_RS18460	COG3135	benzoate transporter
I6H81_RS18465	COG2124	cytochrome p450
I6H81_RS18470	COG0156	8-amino-7-oxononanoate synthase activity
I6H81_RS18480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6H81_RS18495	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6H81_RS18500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H81_RS18505	COG1994	Peptidase M50
I6H81_RS18510	COG0009	L-threonylcarbamoyladenylate synthase
I6H81_RS18525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H81_RS18530	COG3327	negative regulation of DNA-templated transcription, initiation
I6H81_RS18535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H81_RS18565	COG1368	sulfuric ester hydrolase activity
I6H81_RS18575	COG2323	membrane
I6H81_RS18580	COG2010	Cytochrome c
I6H81_RS18585	COG1231	oxidoreductase activity
I6H81_RS18635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H81_RS18640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H81_RS18660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6H81_RS18665	COG0248	Ppx GppA phosphatase
I6H81_RS18675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H81_RS18685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H81_RS18690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6H81_RS18695	COG1534	Rna-binding protein
I6H81_RS18700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H81_RS18705	COG2233	PERMEase
I6H81_RS18725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H81_RS18730	COG0505	Belongs to the CarA family
I6H81_RS18735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H81_RS18740	COG3391	amine dehydrogenase activity
I6H81_RS18750	COG3712	iron ion homeostasis
I6H81_RS18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component