locus-tag	class	description
EGY22_RS00015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_RS00025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EGY22_RS00035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EGY22_RS00040	COG0632	four-way junction helicase activity
EGY22_RS00050	COG2255	four-way junction helicase activity
EGY22_RS00060	COG0418	dihydroorotase activity
EGY22_RS00070	COG0415	Belongs to the DNA photolyase family
EGY22_RS00130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY22_RS00135	COG4654	Cytochrome c, class I
EGY22_RS00175	COG1177	transmembrane transport
EGY22_RS00180	COG3842	ATPase activity
EGY22_RS00185	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_RS00190	COG2084	Dehydrogenase
EGY22_RS00205	COG0494	nUDIX hydrolase
EGY22_RS00210	COG0442	prolyl-tRNA aminoacylation
EGY22_RS00215	COG0824	Thioesterase
EGY22_RS00220	COG0811	peptide transport
EGY22_RS00235	COG0823	Involved in the tonB-independent uptake of proteins
EGY22_RS00250	COG0596	Alpha beta hydrolase
EGY22_RS00275	COG1079	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS00280	COG4603	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS00285	COG3845	ABC transporter
EGY22_RS00305	COG0427	acetyl-CoA hydrolase
EGY22_RS00310	COG0583	DNA-binding transcription factor activity
EGY22_RS00325	COG3634	alkyl hydroperoxide reductase activity
EGY22_RS00340	COG0697	spore germination
EGY22_RS00345	COG0175	sulfate reduction
EGY22_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS00370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS00375	COG5383	Protein conserved in bacteria
EGY22_RS00385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGY22_RS00400	COG0583	DNA-binding transcription factor activity
EGY22_RS00405	COG1741	Belongs to the pirin family
EGY22_RS00415	COG3706	GGDEF domain
EGY22_RS00420	COG0154	amidase activity
EGY22_RS00435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGY22_RS00445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EGY22_RS00450	COG0284	orotidine-5'-phosphate decarboxylase activity
EGY22_RS00465	COG1414	Transcriptional regulator
EGY22_RS00475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGY22_RS00485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY22_RS00490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGY22_RS00515	COG0742	ribosomal rna small subunit methyltransferase
EGY22_RS00520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGY22_RS00525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGY22_RS00555	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EGY22_RS00580	COG1335	isochorismatase
EGY22_RS00585	COG2309	aminopeptidase activity
EGY22_RS00590	COG0596	Alpha beta hydrolase
EGY22_RS00595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_RS00595	COG2010	Cytochrome c
EGY22_RS00600	COG2080	2 iron, 2 sulfur cluster binding
EGY22_RS00605	COG2010	Cytochrome c
EGY22_RS00605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_RS00615	COG0410	ABC transporter
EGY22_RS00620	COG0411	ABC transporter
EGY22_RS00660	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS00680	COG1234	tRNA 3'-trailer cleavage
EGY22_RS00685	COG2188	Transcriptional regulator
EGY22_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY22_RS00705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGY22_RS00705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGY22_RS00710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EGY22_RS00710	COG3608	succinylglutamate desuccinylase aspartoacylase
EGY22_RS00715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS00725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS00730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_RS00755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS00790	COG1335	isochorismatase
EGY22_RS00795	COG2309	aminopeptidase activity
EGY22_RS00800	COG0596	Alpha beta hydrolase
EGY22_RS00815	COG1120	ATPase activity
EGY22_RS00820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY22_RS00830	COG4206	TonB-dependent receptor
EGY22_RS00835	COG2031	fatty acid transporter
EGY22_RS00840	COG0583	DNA-binding transcription factor activity
EGY22_RS00845	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_RS00850	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS00865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_RS00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_RS00875	COG0328	RNA-DNA hybrid ribonuclease activity
EGY22_RS00880	COG2226	methyltransferase
EGY22_RS00885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGY22_RS00890	COG1388	LysM domain
EGY22_RS00890	COG0741	lytic transglycosylase activity
EGY22_RS00910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EGY22_RS00935	COG2204	response regulator
EGY22_RS00940	COG4191	Histidine kinase
EGY22_RS00945	COG1301	dicarboxylic acid transport
EGY22_RS00955	COG1054	Belongs to the UPF0176 family
EGY22_RS00980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY22_RS01000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EGY22_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS01020	COG1877	trehalose-phosphatase activity
EGY22_RS01055	COG0604	alcohol dehydrogenase
EGY22_RS01065	COG1024	Enoyl-CoA hydratase
EGY22_RS01085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EGY22_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS01135	COG1393	Belongs to the ArsC family
EGY22_RS01140	COG0431	NADPH-dependent FMN reductase
EGY22_RS01145	COG0745	RESPONSE REGULATOR receiver
EGY22_RS01150	COG0642	Histidine kinase
EGY22_RS01165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY22_RS01165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGY22_RS01170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGY22_RS01175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_RS01180	COG1881	PFAM PEBP family protein
EGY22_RS01185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGY22_RS01190	COG0739	heme binding
EGY22_RS01195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EGY22_RS01200	COG0316	Belongs to the HesB IscA family
EGY22_RS01210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EGY22_RS01215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGY22_RS01220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGY22_RS01225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS01230	COG0312	modulator of DNA gyrase
EGY22_RS01235	COG3028	Belongs to the UPF0307 family
EGY22_RS01265	COG4566	intracellular signal transduction
EGY22_RS01270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY22_RS01275	COG4681	YaeQ
EGY22_RS01300	COG0762	integral membrane protein
EGY22_RS01305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_RS01305	COG2169	Transcriptional regulator
EGY22_RS01315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY22_RS01330	COG0439	Biotin carboxylase
EGY22_RS01335	COG0511	ligase activity, forming carbon-carbon bonds
EGY22_RS01340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGY22_RS01345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_RS01350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY22_RS01355	COG3150	esterase
EGY22_RS01370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGY22_RS01375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGY22_RS01385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGY22_RS01400	COG1678	Uncharacterized ACR, COG1678
EGY22_RS01415	COG0352	thiamine-phosphate diphosphorylase activity
EGY22_RS01420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGY22_RS01435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGY22_RS01445	COG3237	CsbD-like
EGY22_RS01450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGY22_RS01455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGY22_RS01460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGY22_RS01465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGY22_RS01490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGY22_RS01510	COG1126	abc transporter atp-binding protein
EGY22_RS01515	COG0765	amino acid transport
EGY22_RS01520	COG4597	amino acid ABC transporter
EGY22_RS01525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS01530	COG2884	Cell division ATP-binding protein ftsE
EGY22_RS01535	COG2177	Part of the ABC transporter FtsEX involved in
EGY22_RS01545	COG0772	Belongs to the SEDS family
EGY22_RS01550	COG0768	penicillin binding
EGY22_RS01560	COG1792	Involved in formation and maintenance of cell shape
EGY22_RS01565	COG1077	Cell shape determining protein MreB Mrl
EGY22_RS01570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGY22_RS01575	COG0154	amidase activity
EGY22_RS01580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGY22_RS01585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EGY22_RS01590	COG0583	DNA-binding transcription factor activity
EGY22_RS01595	COG2259	Doxx family
EGY22_RS01600	COG3384	dioxygenase
EGY22_RS01610	COG3245	cytochrome
EGY22_RS01625	COG3604	Transcriptional regulator
EGY22_RS01640	COG0786	glutamate:sodium symporter activity
EGY22_RS01645	COG0142	geranyltranstransferase activity
EGY22_RS01655	COG0494	nUDIX hydrolase
EGY22_RS01660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EGY22_RS01685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EGY22_RS01690	COG0237	dephospho-CoA kinase activity
EGY22_RS01705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EGY22_RS01710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGY22_RS01720	COG0477	Major facilitator Superfamily
EGY22_RS01725	COG0259	pyridoxamine-phosphate oxidase activity
EGY22_RS01775	COG4206	TonB-dependent receptor
EGY22_RS01780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGY22_RS01795	COG1595	DNA-templated transcription, initiation
EGY22_RS01805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS01825	COG0598	Magnesium transport protein CorA
EGY22_RS01840	COG2022	thiamine diphosphate biosynthetic process
EGY22_RS01845	COG0351	phosphomethylpyrimidine kinase
EGY22_RS01850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY22_RS01855	COG3344	reverse transcriptase
EGY22_RS01860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGY22_RS01865	COG1538	Outer membrane efflux protein
EGY22_RS01870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGY22_RS01880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGY22_RS01895	COG2226	methyltransferase
EGY22_RS01900	COG0745	RESPONSE REGULATOR receiver
EGY22_RS01915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EGY22_RS01920	COG1984	allophanate hydrolase subunit 2
EGY22_RS01925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY22_RS01930	COG1238	metal cluster binding
EGY22_RS01965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGY22_RS01970	COG4988	ABC transporter
EGY22_RS01980	COG1294	oxidase, subunit
EGY22_RS01985	COG1271	oxidase subunit
EGY22_RS02000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EGY22_RS02015	COG1137	ATPase activity
EGY22_RS02025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY22_RS02030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGY22_RS02035	COG1660	Displays ATPase and GTPase activities
EGY22_RS02045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGY22_RS02050	COG0792	nuclease activity
EGY22_RS02055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGY22_RS02070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY22_RS02090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGY22_RS02095	COG0793	Belongs to the peptidase S41A family
EGY22_RS02105	COG0588	phosphoglycerate mutase activity
EGY22_RS02110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGY22_RS02120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EGY22_RS02125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGY22_RS02130	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS02135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGY22_RS02140	COG1040	competence protein
EGY22_RS02145	COG2226	methyltransferase
EGY22_RS02150	COG4771	TonB-dependent receptor
EGY22_RS02155	COG0745	RESPONSE REGULATOR receiver
EGY22_RS02170	COG2204	response regulator
EGY22_RS02190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGY22_RS02200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGY22_RS02205	COG3473	Maleate cis-trans isomerase
EGY22_RS02220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_RS02235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGY22_RS02235	COG2755	lipolytic protein G-D-S-L family
EGY22_RS02245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGY22_RS02250	COG1216	Glycosyl transferase, family 2
EGY22_RS02260	COG3039	Transposase
EGY22_RS02335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGY22_RS02345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGY22_RS02350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EGY22_RS02355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGY22_RS02370	COG0356	it plays a direct role in the translocation of protons across the membrane
EGY22_RS02380	COG1024	Enoyl-CoA hydratase
EGY22_RS02395	COG0037	tRNA processing
EGY22_RS02400	COG0163	prenyltransferase activity
EGY22_RS02405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EGY22_RS02410	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY22_RS02450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGY22_RS02455	COG2264	protein methyltransferase activity
EGY22_RS02460	COG4773	Receptor
EGY22_RS02485	COG3180	Ammonia monooxygenase
EGY22_RS02505	COG5002	protein histidine kinase activity
EGY22_RS02520	COG0477	Major facilitator Superfamily
EGY22_RS02525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_RS02545	COG1116	anion transmembrane transporter activity
EGY22_RS02570	COG3383	formate dehydrogenase (NAD+) activity
EGY22_RS02570	COG0243	molybdopterin cofactor binding
EGY22_RS02575	COG3383	formate dehydrogenase (NAD+) activity
EGY22_RS02575	COG0243	molybdopterin cofactor binding
EGY22_RS02580	COG0437	4 iron, 4 sulfur cluster binding
EGY22_RS02585	COG2864	formate dehydrogenase
EGY22_RS02595	COG1921	L-seryl-tRNASec selenium transferase activity
EGY22_RS02600	COG3276	selenocysteine insertion sequence binding
EGY22_RS02610	COG1476	TRANSCRIPTIONal
EGY22_RS02625	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS02645	COG0709	Synthesizes selenophosphate from selenide and ATP
EGY22_RS02660	COG0583	DNA-binding transcription factor activity
EGY22_RS02665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EGY22_RS02670	COG3901	Regulator of nitric oxide reductase transcription
EGY22_RS02670	COG0348	domain, Protein
EGY22_RS02675	COG4263	nitrous-oxide reductase activity
EGY22_RS02690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EGY22_RS02705	COG0166	Belongs to the GPI family
EGY22_RS02730	COG1215	transferase activity, transferring glycosyl groups
EGY22_RS02775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGY22_RS02810	COG0156	8-amino-7-oxononanoate synthase activity
EGY22_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS02815	COG0604	alcohol dehydrogenase
EGY22_RS02815	COG3321	synthase
EGY22_RS02825	COG2233	PERMEase
EGY22_RS02830	COG0697	spore germination
EGY22_RS02835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS02840	COG0697	spore germination
EGY22_RS02860	COG2885	chlorophyll binding
EGY22_RS02955	COG0183	Belongs to the thiolase family
EGY22_RS02960	COG1024	Enoyl-CoA hydratase
EGY22_RS02960	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY22_RS02975	COG1127	ABC transporter
EGY22_RS02980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGY22_RS02985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_RS03000	COG1131	(ABC) transporter
EGY22_RS03005	COG0842	Transport permease protein
EGY22_RS03015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGY22_RS03025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EGY22_RS03030	COG0131	Imidazoleglycerol-phosphate dehydratase
EGY22_RS03040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGY22_RS03045	COG0107	imidazoleglycerol-phosphate synthase activity
EGY22_RS03055	COG0140	phosphoribosyl-ATP diphosphatase activity
EGY22_RS03060	COG0537	adenosine 5'-monophosphoramidase activity
EGY22_RS03065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGY22_RS03070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGY22_RS03080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY22_RS03090	COG1970	mechanosensitive ion channel activity
EGY22_RS03095	COG0723	plastoquinol--plastocyanin reductase activity
EGY22_RS03100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EGY22_RS03105	COG2857	Cytochrome c1
EGY22_RS03110	COG0625	glutathione transferase activity
EGY22_RS03115	COG2969	positive regulation of protein catabolic process
EGY22_RS03120	COG4208	sulfate ABC transporter
EGY22_RS03125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_RS03130	COG4150	thiosulfate binding
EGY22_RS03145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_RS03165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS03170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_RS03175	COG3622	Belongs to the hyi family
EGY22_RS03185	COG0129	dihydroxy-acid dehydratase activity
EGY22_RS03190	COG1802	Transcriptional regulator
EGY22_RS03195	COG1522	sequence-specific DNA binding
EGY22_RS03205	COG3483	tryptophan 2,3-dioxygenase activity
EGY22_RS03225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EGY22_RS03230	COG0656	L-ascorbic acid biosynthetic process
EGY22_RS03240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGY22_RS03245	COG3706	GGDEF domain
EGY22_RS03250	COG2226	methyltransferase
EGY22_RS03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_RS03275	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGY22_RS03280	COG0583	DNA-binding transcription factor activity
EGY22_RS03285	COG0477	Major facilitator Superfamily
EGY22_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS03300	COG1335	isochorismatase
EGY22_RS03305	COG1335	isochorismatase
EGY22_RS03325	COG2823	Periplasmic or secreted lipoprotein
EGY22_RS03335	COG3284	Transcriptional regulator
EGY22_RS03365	COG1595	DNA-templated transcription, initiation
EGY22_RS03375	COG1522	sequence-specific DNA binding
EGY22_RS03385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGY22_RS03405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGY22_RS03440	COG0109	protoheme IX farnesyltransferase activity
EGY22_RS03460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGY22_RS03465	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGY22_RS03480	COG3568	Endonuclease Exonuclease Phosphatase
EGY22_RS03485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGY22_RS03510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS03520	COG1228	amidohydrolase
EGY22_RS03540	COG2986	histidine ammonia-lyase
EGY22_RS03545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EGY22_RS03575	COG2814	Major facilitator Superfamily
EGY22_RS03585	COG0789	Transcriptional regulator
EGY22_RS03615	COG0625	glutathione transferase activity
EGY22_RS03625	COG1017	nitric oxide dioxygenase activity
EGY22_RS03625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY22_RS03645	COG2365	Tyrosine phosphatase family
EGY22_RS03650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EGY22_RS03670	COG2423	ornithine cyclodeaminase activity
EGY22_RS03720	COG3069	C4-dicarboxylate transmembrane transporter activity
EGY22_RS03730	COG1802	Transcriptional regulator
EGY22_RS03740	COG2814	Major facilitator Superfamily
EGY22_RS03755	COG2814	Major facilitator Superfamily
EGY22_RS03760	COG0251	oxidation-reduction process
EGY22_RS03765	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS03770	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_RS03775	COG2186	Transcriptional regulator
EGY22_RS03785	COG2814	Major facilitator Superfamily
EGY22_RS03795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EGY22_RS03800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGY22_RS03805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGY22_RS03825	COG5001	Diguanylate cyclase
EGY22_RS03825	COG5002	protein histidine kinase activity
EGY22_RS03840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGY22_RS03845	COG1333	cytochrome c biogenesis protein
EGY22_RS03855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EGY22_RS03860	COG0113	porphobilinogen synthase activity
EGY22_RS03865	COG4232	protein-disulfide reductase activity
EGY22_RS03885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_RS03890	COG0203	ribosomal protein L17
EGY22_RS03895	COG0202	RNA polymerase activity
EGY22_RS03900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGY22_RS03905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGY22_RS03910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGY22_RS03915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGY22_RS03925	COG0201	protein transport
EGY22_RS03930	COG0200	Binds to the 23S rRNA
EGY22_RS03935	COG1841	ribosomal large subunit assembly
EGY22_RS03940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGY22_RS03945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGY22_RS03950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGY22_RS03955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EGY22_RS03960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGY22_RS03965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGY22_RS03970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGY22_RS03975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGY22_RS04015	COG1538	Outer membrane efflux protein
EGY22_RS04030	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS04035	COG0183	Belongs to the thiolase family
EGY22_RS04045	COG2067	long-chain fatty acid transport protein
EGY22_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_RS04065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGY22_RS04070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGY22_RS04075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_RS04075	COG1648	precorrin-2 dehydrogenase activity
EGY22_RS04090	COG1116	anion transmembrane transporter activity
EGY22_RS04110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EGY22_RS04115	COG0255	Belongs to the universal ribosomal protein uL29 family
EGY22_RS04120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGY22_RS04125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGY22_RS04130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGY22_RS04135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGY22_RS04140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGY22_RS04145	COG0089	rRNA binding
EGY22_RS04150	COG0088	Forms part of the polypeptide exit tunnel
EGY22_RS04155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGY22_RS04160	COG4175	Glycine betaine
EGY22_RS04165	COG4176	ABC-type proline glycine betaine transport system permease component
EGY22_RS04170	COG0051	transcription antitermination factor activity, RNA binding
EGY22_RS04175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY22_RS04180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGY22_RS04185	COG0049	tRNA binding
EGY22_RS04190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGY22_RS04195	COG0745	RESPONSE REGULATOR receiver
EGY22_RS04220	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EGY22_RS04225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGY22_RS04230	COG0085	RNA polymerase activity
EGY22_RS04235	COG0222	ribosome binding
EGY22_RS04240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGY22_RS04245	COG0081	regulation of translation
EGY22_RS04270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGY22_RS04290	COG1475	DNA binding
EGY22_RS04295	COG1192	Involved in chromosome partitioning
EGY22_RS04300	COG0357	Ribosomal RNA small subunit methyltransferase G
EGY22_RS04305	COG0445	tRNA wobble uridine modification
EGY22_RS04310	COG0436	Aminotransferase
EGY22_RS04315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGY22_RS04325	COG3706	GGDEF domain
EGY22_RS04330	COG0688	phosphatidylethanolamine metabolic process
EGY22_RS04340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGY22_RS04380	COG3645	SOS response
EGY22_RS04385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGY22_RS04420	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS04440	COG0596	Alpha beta hydrolase
EGY22_RS04445	COG2309	aminopeptidase activity
EGY22_RS04450	COG1335	isochorismatase
EGY22_RS04475	COG0753	catalase activity
EGY22_RS04480	COG0706	membrane insertase activity
EGY22_RS04485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGY22_RS04490	COG0594	ribonuclease P activity
EGY22_RS04495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EGY22_RS04500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGY22_RS04505	COG0592	DNA-directed DNA polymerase activity
EGY22_RS04515	COG1187	pseudouridine synthase activity
EGY22_RS04530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS04560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS04565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_RS04585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS04605	COG2070	2-Nitropropane dioxygenase
EGY22_RS04615	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS04625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS04635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS04645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS04665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGY22_RS04670	COG0583	DNA-binding transcription factor activity
EGY22_RS04680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS04690	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS04705	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_RS04715	COG0596	Alpha beta hydrolase
EGY22_RS04715	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_RS04720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS04735	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS04745	COG0697	spore germination
EGY22_RS04750	COG0583	DNA-binding transcription factor activity
EGY22_RS04760	COG3842	ATPase activity
EGY22_RS04770	COG0436	Aminotransferase
EGY22_RS04780	COG0523	cobalamin synthesis protein
EGY22_RS04840	COG1846	Transcriptional regulator
EGY22_RS04860	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_RS04865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_RS04870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EGY22_RS04880	COG4638	Rieske (2fe-2S)
EGY22_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS04955	COG2207	Transcriptional regulator
EGY22_RS04985	COG1595	DNA-templated transcription, initiation
EGY22_RS04990	COG4608	Belongs to the ABC transporter superfamily
EGY22_RS04995	COG0444	Belongs to the ABC transporter superfamily
EGY22_RS05000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY22_RS05005	COG0601	transmembrane transport
EGY22_RS05015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGY22_RS05020	COG1595	DNA-templated transcription, initiation
EGY22_RS05025	COG3712	iron ion homeostasis
EGY22_RS05030	COG4774	siderophore transport
EGY22_RS05035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGY22_RS05040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGY22_RS05055	COG1464	Belongs to the NlpA lipoprotein family
EGY22_RS05060	COG1464	Belongs to the NlpA lipoprotein family
EGY22_RS05065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_RS05070	COG2011	ABC-type metal ion transport system permease component
EGY22_RS05095	COG1464	Belongs to the NlpA lipoprotein family
EGY22_RS05105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGY22_RS05125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_RS05130	COG0431	NADPH-dependent FMN reductase
EGY22_RS05165	COG4149	molybdate abc transporter
EGY22_RS05175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EGY22_RS05180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGY22_RS05190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS05210	COG0028	Belongs to the TPP enzyme family
EGY22_RS05215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS05245	COG2922	Belongs to the Smg family
EGY22_RS05260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGY22_RS05265	COG0183	Belongs to the thiolase family
EGY22_RS05270	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EGY22_RS05275	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS05295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY22_RS05305	COG0018	arginyl-trna synthetase
EGY22_RS05330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_RS05340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EGY22_RS05345	COG4774	siderophore transport
EGY22_RS05350	COG0066	3-isopropylmalate dehydratase activity
EGY22_RS05355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGY22_RS05360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_RS05365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS05370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS05370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGY22_RS05380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS05385	COG1335	isochorismatase
EGY22_RS05390	COG0583	DNA-binding transcription factor activity
EGY22_RS05410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGY22_RS05415	COG1280	lysine exporter protein (LysE YggA)
EGY22_RS05420	COG0513	Belongs to the DEAD box helicase family
EGY22_RS05430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EGY22_RS05445	COG1160	GTP binding
EGY22_RS05460	COG0154	amidase activity
EGY22_RS05475	COG0583	DNA-binding transcription factor activity
EGY22_RS05505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGY22_RS05510	COG1127	ABC transporter
EGY22_RS05515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_RS05515	COG3218	ABC-type transport auxiliary lipoprotein component
EGY22_RS05530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY22_RS05535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS05545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS05575	COG0583	DNA-binding transcription factor activity
EGY22_RS05595	COG3093	addiction module antidote protein HigA
EGY22_RS05620	COG2358	TRAP transporter, solute receptor (TAXI family
EGY22_RS05630	COG0564	pseudouridine synthase activity
EGY22_RS05635	COG0252	asparaginase activity
EGY22_RS05660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGY22_RS05665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGY22_RS05670	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS05690	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS05715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS05730	COG0758	DNA mediated transformation
EGY22_RS05735	COG0242	peptide deformylase activity
EGY22_RS05740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGY22_RS05745	COG0697	spore germination
EGY22_RS05760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS05775	COG4336	lyase activity
EGY22_RS05780	COG0583	DNA-binding transcription factor activity
EGY22_RS05785	COG0859	PFAM glycosyl transferase family 9
EGY22_RS05795	COG1278	Cold shock
EGY22_RS05800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGY22_RS05805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EGY22_RS05810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EGY22_RS05810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EGY22_RS05820	COG1686	Belongs to the peptidase S11 family
EGY22_RS05830	COG2921	Belongs to the UPF0250 family
EGY22_RS05835	COG0321	lipoyl(octanoyl) transferase activity
EGY22_RS05840	COG1024	Enoyl-CoA hydratase
EGY22_RS05845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGY22_RS05855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGY22_RS05900	COG0826	peptidase U32
EGY22_RS05910	COG3154	lipid carrier protein
EGY22_RS05935	COG0134	indole-3-glycerol-phosphate synthase activity
EGY22_RS05940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGY22_RS05945	COG0512	Glutamine amidotransferase of anthranilate synthase
EGY22_RS05955	COG0546	phosphoglycolate phosphatase activity
EGY22_RS05965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGY22_RS05970	COG2967	ApaG domain
EGY22_RS05975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EGY22_RS05980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_RS05985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGY22_RS05995	COG0840	transmembrane signaling receptor activity
EGY22_RS06005	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS06010	COG1535	isochorismatase
EGY22_RS06010	COG3433	isochorismatase activity
EGY22_RS06015	COG1169	isochorismate synthase
EGY22_RS06030	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EGY22_RS06030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGY22_RS06035	COG1535	isochorismatase
EGY22_RS06035	COG3433	isochorismatase activity
EGY22_RS06040	COG1021	2,3-dihydroxybenzoate-AMP ligase
EGY22_RS06070	COG0683	leucine binding
EGY22_RS06085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS06120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EGY22_RS06125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY22_RS06130	COG2819	hydrolase of the alpha beta superfamily
EGY22_RS06135	COG0513	Belongs to the DEAD box helicase family
EGY22_RS06140	COG2814	Major facilitator Superfamily
EGY22_RS06150	COG0583	DNA-binding transcription factor activity
EGY22_RS06160	COG1253	flavin adenine dinucleotide binding
EGY22_RS06195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGY22_RS06215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY22_RS06235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS06240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_RS06250	COG0583	DNA-binding transcription factor activity
EGY22_RS06255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS06265	COG0765	amino acid transport
EGY22_RS06270	COG0765	amino acid transport
EGY22_RS06275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_RS06285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_RS06300	COG3391	amine dehydrogenase activity
EGY22_RS06310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGY22_RS06335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGY22_RS06340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGY22_RS06345	COG0210	DNA helicase
EGY22_RS06360	COG0067	glutamate synthase
EGY22_RS06360	COG0069	glutamate synthase activity
EGY22_RS06360	COG0070	glutamate synthase
EGY22_RS06365	COG1024	Enoyl-CoA hydratase
EGY22_RS06375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS06380	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGY22_RS06410	COG2918	glutathione biosynthetic process
EGY22_RS06420	COG2197	response regulator
EGY22_RS06425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_RS06435	COG2223	nitrite transmembrane transporter activity
EGY22_RS06440	COG2860	membrane
EGY22_RS06445	COG1346	cytolysis
EGY22_RS06460	COG0251	oxidation-reduction process
EGY22_RS06475	COG5295	Hep Hag repeat protein
EGY22_RS06490	COG1280	lysine exporter protein (LysE YggA)
EGY22_RS06500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY22_RS06515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGY22_RS06530	COG2096	Adenosyltransferase
EGY22_RS06545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EGY22_RS06550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EGY22_RS06560	COG0523	cobalamin synthesis protein
EGY22_RS06565	COG0735	belongs to the Fur family
EGY22_RS06575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGY22_RS06580	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGY22_RS06585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EGY22_RS06595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGY22_RS06600	COG1560	Kdo2-lipid A biosynthetic process
EGY22_RS06610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGY22_RS06615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGY22_RS06620	COG1950	PFAM Membrane protein of
EGY22_RS06655	COG0275	rRNA processing
EGY22_RS06660	COG0730	response to heat
EGY22_RS06665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGY22_RS06670	COG0129	dihydroxy-acid dehydratase activity
EGY22_RS06675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGY22_RS06695	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS06705	COG0628	permease
EGY22_RS06720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS06760	COG1021	2,3-dihydroxybenzoate-AMP ligase
EGY22_RS06775	COG2814	Major facilitator Superfamily
EGY22_RS06785	COG0656	L-ascorbic acid biosynthetic process
EGY22_RS06790	COG2814	Major facilitator Superfamily
EGY22_RS06795	COG0583	DNA-binding transcription factor activity
EGY22_RS06805	COG3685	Protein conserved in bacteria
EGY22_RS06825	COG1846	Transcriptional regulator
EGY22_RS06840	COG4774	siderophore transport
EGY22_RS06845	COG4607	ABC-type enterochelin transport system periplasmic component
EGY22_RS06850	COG4604	ABC transporter, ATP-binding protein
EGY22_RS06855	COG4605	iron ion homeostasis
EGY22_RS06860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGY22_RS06865	COG1132	(ABC) transporter
EGY22_RS06870	COG1132	(ABC) transporter
EGY22_RS06870	COG2375	cellular response to nickel ion
EGY22_RS06875	COG0277	FAD linked oxidase domain protein
EGY22_RS06880	COG1304	FMN binding
EGY22_RS06885	COG2186	Transcriptional regulator
EGY22_RS06905	COG1609	Transcriptional regulator
EGY22_RS06910	COG1522	sequence-specific DNA binding
EGY22_RS06915	COG3844	kynureninase activity
EGY22_RS06920	COG1113	amino acid transport
EGY22_RS06950	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS06955	COG1349	DNA-binding transcription factor activity
EGY22_RS06960	COG3842	ATPase activity
EGY22_RS06975	COG0395	ABC-type sugar transport system, permease component
EGY22_RS07000	COG0861	Integral membrane protein TerC family
EGY22_RS07005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_RS07015	COG1671	Belongs to the UPF0178 family
EGY22_RS07025	COG1418	mRNA catabolic process
EGY22_RS07035	COG4948	Mandelate Racemase Muconate Lactonizing
EGY22_RS07045	COG0477	Major facilitator Superfamily
EGY22_RS07060	COG0154	amidase activity
EGY22_RS07070	COG0583	DNA-binding transcription factor activity
EGY22_RS07095	COG0326	Molecular chaperone. Has ATPase activity
EGY22_RS07105	COG3128	pkhd-type hydroxylase
EGY22_RS07115	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY22_RS07130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGY22_RS07135	COG1652	LysM domain
EGY22_RS07150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGY22_RS07175	COG1535	isochorismatase
EGY22_RS07175	COG3433	isochorismatase activity
EGY22_RS07200	COG0583	DNA-binding transcription factor activity
EGY22_RS07205	COG0387	Pfam Sodium calcium exchanger
EGY22_RS07220	COG0477	Major facilitator Superfamily
EGY22_RS07225	COG0235	Class ii aldolase
EGY22_RS07235	COG3391	amine dehydrogenase activity
EGY22_RS07240	COG0590	tRNA wobble adenosine to inosine editing
EGY22_RS07245	COG3257	ureidoglycine aminohydrolase activity
EGY22_RS07250	COG0583	DNA-binding transcription factor activity
EGY22_RS07255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGY22_RS07260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_RS07260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_RS07270	COG0489	protein tyrosine kinase activity
EGY22_RS07295	COG2081	HI0933 family
EGY22_RS07300	COG0509	glycine decarboxylation via glycine cleavage system
EGY22_RS07310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGY22_RS07315	COG1765	OsmC-like protein
EGY22_RS07320	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_RS07345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EGY22_RS07350	COG0469	pyruvate kinase activity
EGY22_RS07355	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EGY22_RS07365	COG2084	Dehydrogenase
EGY22_RS07370	COG3622	Belongs to the hyi family
EGY22_RS07375	COG3960	tartronate-semialdehyde synthase activity
EGY22_RS07380	COG0583	DNA-binding transcription factor activity
EGY22_RS07390	COG2233	PERMEase
EGY22_RS07395	COG1942	4-Oxalocrotonate Tautomerase
EGY22_RS07400	COG0235	Class ii aldolase
EGY22_RS07410	COG3195	allantoin biosynthetic process
EGY22_RS07410	COG3648	Uricase
EGY22_RS07420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY22_RS07425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EGY22_RS07440	COG0438	transferase activity, transferring glycosyl groups
EGY22_RS07450	COG0438	transferase activity, transferring glycosyl groups
EGY22_RS07460	COG0277	FAD linked oxidase domain protein
EGY22_RS07470	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGY22_RS07475	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EGY22_RS07485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_RS07495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGY22_RS07505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EGY22_RS07520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGY22_RS07525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGY22_RS07530	COG0193	aminoacyl-tRNA hydrolase activity
EGY22_RS07540	COG0012	GTP binding
EGY22_RS07560	COG1024	Enoyl-CoA hydratase
EGY22_RS07565	COG0367	asparagine synthase
EGY22_RS07580	COG0488	(ABC) transporter
EGY22_RS07595	COG0288	reversible hydration of carbon dioxide
EGY22_RS07600	COG0583	DNA-binding transcription factor activity
EGY22_RS07630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EGY22_RS07640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_RS07645	COG3088	subunit of a heme lyase
EGY22_RS07650	COG4235	cytochrome complex assembly
EGY22_RS07655	COG0785	Cytochrome C biogenesis protein
EGY22_RS07665	COG2169	Transcriptional regulator
EGY22_RS07665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGY22_RS07685	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS07695	COG0411	ABC transporter
EGY22_RS07705	COG1858	cytochrome C peroxidase
EGY22_RS07710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGY22_RS07715	COG1959	2 iron, 2 sulfur cluster binding
EGY22_RS07720	COG2346	COG2346, Truncated hemoglobins
EGY22_RS07725	COG0463	Glycosyl transferase, family 2
EGY22_RS07765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EGY22_RS07770	COG3383	formate dehydrogenase (NAD+) activity
EGY22_RS07785	COG1910	domain protein
EGY22_RS07790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGY22_RS07800	COG0303	'Molybdopterin
EGY22_RS07805	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY22_RS07810	COG0314	molybdopterin synthase activity
EGY22_RS07820	COG0315	cyclic pyranopterin monophosphate synthase activity
EGY22_RS07850	COG0678	peroxiredoxin activity
EGY22_RS07865	COG0697	spore germination
EGY22_RS07870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGY22_RS07950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EGY22_RS07955	COG4535	Mg2 and Co2 transporter CorC
EGY22_RS07960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGY22_RS07965	COG1702	phosphate starvation-inducible protein PhoH
EGY22_RS07970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGY22_RS07985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY22_RS07990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGY22_RS07995	COG1862	Preprotein translocase
EGY22_RS08000	COG0343	queuine tRNA-ribosyltransferase activity
EGY22_RS08005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGY22_RS08010	COG2027	D-alanyl-D-alanine carboxypeptidase
EGY22_RS08015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGY22_RS08025	COG4575	ribosome binding
EGY22_RS08040	COG0583	DNA-binding transcription factor activity
EGY22_RS08055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_RS08070	COG0154	amidase activity
EGY22_RS08080	COG0477	Major facilitator Superfamily
EGY22_RS08095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EGY22_RS08105	COG0436	Aminotransferase
EGY22_RS08115	COG0281	malic enzyme
EGY22_RS08115	COG0280	phosphate acetyltransferase
EGY22_RS08125	COG2732	(Barnase) inhibitor
EGY22_RS08130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGY22_RS08135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EGY22_RS08140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY22_RS08145	COG0126	phosphoglycerate kinase activity
EGY22_RS08170	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGY22_RS08180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGY22_RS08185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGY22_RS08190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGY22_RS08195	COG0009	L-threonylcarbamoyladenylate synthase
EGY22_RS08200	COG0596	Alpha beta hydrolase
EGY22_RS08205	COG2030	dehydratase
EGY22_RS08205	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS08210	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS08220	COG0405	Gamma-glutamyltransferase
EGY22_RS08230	COG0579	oxidoreductase
EGY22_RS08235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGY22_RS08240	COG0259	pyridoxamine-phosphate oxidase activity
EGY22_RS08250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGY22_RS08265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGY22_RS08270	COG1215	transferase activity, transferring glycosyl groups
EGY22_RS08280	COG0488	(ABC) transporter
EGY22_RS08300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EGY22_RS08305	COG2894	cell division
EGY22_RS08315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGY22_RS08320	COG1271	oxidase subunit
EGY22_RS08325	COG1294	oxidase, subunit
EGY22_RS08330	COG0038	chloride channel
EGY22_RS08340	COG0514	ATP-dependent DNA helicase (RecQ)
EGY22_RS08345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGY22_RS08350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGY22_RS08355	COG0633	Ferredoxin
EGY22_RS08360	COG0488	(ABC) transporter
EGY22_RS08370	COG2001	Belongs to the MraZ family
EGY22_RS08375	COG0275	rRNA processing
EGY22_RS08380	COG3116	cell division
EGY22_RS08390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGY22_RS08395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGY22_RS08400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGY22_RS08410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGY22_RS08415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGY22_RS08420	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGY22_RS08425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGY22_RS08440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EGY22_RS08450	COG0741	lytic transglycosylase activity
EGY22_RS08450	COG1196	nuclear chromosome segregation
EGY22_RS08450	COG0739	heme binding
EGY22_RS08455	COG0653	protein targeting
EGY22_RS08465	COG2239	Acts as a magnesium transporter
EGY22_RS08475	COG1473	amidohydrolase
EGY22_RS08480	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_RS08490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS08490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGY22_RS08505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_RS08510	COG2011	ABC-type metal ion transport system permease component
EGY22_RS08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS08525	COG0765	amino acid transport
EGY22_RS08530	COG1126	abc transporter atp-binding protein
EGY22_RS08540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EGY22_RS08555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_RS08560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGY22_RS08565	COG0700	Nucleoside recognition
EGY22_RS08580	COG0204	Acyl-transferase
EGY22_RS08585	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EGY22_RS08590	COG0751	glycine-tRNA ligase activity
EGY22_RS08595	COG0752	glycyl-tRNA synthetase alpha subunit
EGY22_RS08600	COG1024	Enoyl-CoA hydratase
EGY22_RS08610	COG1309	transcriptional regulator
EGY22_RS08620	COG2814	Major facilitator Superfamily
EGY22_RS08635	COG1573	uracil-dna glycosylase
EGY22_RS08640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGY22_RS08645	COG0617	tRNA 3'-terminal CCA addition
EGY22_RS08655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGY22_RS08660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGY22_RS08665	COG1953	Uracil, thiamine, allantoin
EGY22_RS08670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGY22_RS08675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGY22_RS08680	COG0586	Pfam SNARE associated Golgi protein
EGY22_RS08685	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGY22_RS08690	COG0802	atpase or kinase
EGY22_RS08700	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS08705	COG0281	malic enzyme
EGY22_RS08705	COG0280	phosphate acetyltransferase
EGY22_RS08710	COG0583	DNA-binding transcription factor activity
EGY22_RS08715	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS08720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_RS08740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS08770	COG1733	regulation of RNA biosynthetic process
EGY22_RS08775	COG2910	NAD(P)H-binding
EGY22_RS08785	COG2223	nitrite transmembrane transporter activity
EGY22_RS08790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGY22_RS08795	COG4974	Belongs to the 'phage' integrase family
EGY22_RS08800	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGY22_RS08805	COG4149	molybdate abc transporter
EGY22_RS08810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_RS08825	COG1074	ATP-dependent DNA helicase activity
EGY22_RS08860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS08870	COG3712	iron ion homeostasis
EGY22_RS08880	COG3391	amine dehydrogenase activity
EGY22_RS08885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGY22_RS08890	COG0505	Belongs to the CarA family
EGY22_RS08895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGY22_RS08915	COG2233	PERMEase
EGY22_RS08920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGY22_RS08925	COG1534	Rna-binding protein
EGY22_RS08930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EGY22_RS08935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGY22_RS08940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGY22_RS08945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGY22_RS08955	COG0248	Ppx GppA phosphatase
EGY22_RS08960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGY22_RS08980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGY22_RS08985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGY22_RS09035	COG1231	oxidoreductase activity
EGY22_RS09040	COG2010	Cytochrome c
EGY22_RS09045	COG2323	membrane
EGY22_RS09055	COG1368	sulfuric ester hydrolase activity
EGY22_RS09085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_RS09090	COG3327	negative regulation of DNA-templated transcription, initiation
EGY22_RS09095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGY22_RS09110	COG0009	L-threonylcarbamoyladenylate synthase
EGY22_RS09115	COG1994	Peptidase M50
EGY22_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGY22_RS09125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EGY22_RS09140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EGY22_RS09150	COG0156	8-amino-7-oxononanoate synthase activity
EGY22_RS09155	COG2124	cytochrome p450
EGY22_RS09160	COG3135	benzoate transporter
EGY22_RS09170	COG2850	peptidyl-arginine hydroxylation
EGY22_RS09175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EGY22_RS09180	COG3391	amine dehydrogenase activity
EGY22_RS09190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_RS09195	COG1136	(ABC) transporter
EGY22_RS09195	COG0577	efflux transmembrane transporter activity
EGY22_RS09200	COG1538	Outer membrane efflux protein
EGY22_RS09205	COG0363	glucosamine-6-phosphate deaminase activity
EGY22_RS09210	COG1132	(ABC) transporter
EGY22_RS09220	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS09230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGY22_RS09240	COG0668	transmembrane transport
EGY22_RS09250	COG3321	synthase
EGY22_RS09250	COG0604	alcohol dehydrogenase
EGY22_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS09285	COG0154	amidase activity
EGY22_RS09290	COG2031	fatty acid transporter
EGY22_RS09305	COG0483	inositol monophosphate 1-phosphatase activity
EGY22_RS09310	COG1253	flavin adenine dinucleotide binding
EGY22_RS09315	COG1968	undecaprenyl-diphosphatase activity
EGY22_RS09335	COG0215	cysteine-tRNA ligase activity
EGY22_RS09345	COG0825	malonyl-CoA metabolic process
EGY22_RS09350	COG0037	tRNA processing
EGY22_RS09370	COG0330	HflC and HflK could
EGY22_RS09385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_RS09405	COG4208	sulfate ABC transporter
EGY22_RS09410	COG3842	ATPase activity
EGY22_RS09420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EGY22_RS09450	COG1304	FMN binding
EGY22_RS09455	COG0435	Glutathione S-transferase
EGY22_RS09460	COG0655	NAD(P)H dehydrogenase (quinone) activity
EGY22_RS09480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGY22_RS09485	COG2363	Small membrane protein
EGY22_RS09490	COG0598	Magnesium transport protein CorA
EGY22_RS09495	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS09505	COG0747	negative chemotaxis
EGY22_RS09515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY22_RS09520	COG4172	Belongs to the ABC transporter superfamily
EGY22_RS09530	COG3284	Transcriptional regulator
EGY22_RS09535	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS09540	COG1454	alcohol dehydrogenase
EGY22_RS09545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGY22_RS09570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EGY22_RS09600	COG3829	transcription factor binding
EGY22_RS09605	COG0477	Major facilitator Superfamily
EGY22_RS09615	COG0039	L-malate dehydrogenase activity
EGY22_RS09620	COG2188	Transcriptional regulator
EGY22_RS09625	COG2009	succinate dehydrogenase
EGY22_RS09635	COG1053	succinate dehydrogenase
EGY22_RS09640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGY22_RS09645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EGY22_RS09650	COG0372	Belongs to the citrate synthase family
EGY22_RS09655	COG2186	Transcriptional regulator
EGY22_RS09660	COG1620	l-lactate permease
EGY22_RS09665	COG0280	phosphate acetyltransferase
EGY22_RS09665	COG0281	malic enzyme
EGY22_RS09670	COG0567	Dehydrogenase, E1 component
EGY22_RS09675	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_RS09680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY22_RS09685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EGY22_RS09705	COG2183	response to ionizing radiation
EGY22_RS09710	COG1199	ATP-dependent helicase activity
EGY22_RS09720	COG1733	regulation of RNA biosynthetic process
EGY22_RS09740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS09740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGY22_RS09745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS09755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGY22_RS09755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS09770	COG0564	pseudouridine synthase activity
EGY22_RS09780	COG3243	poly(R)-hydroxyalkanoic acid synthase
EGY22_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS09790	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EGY22_RS09815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGY22_RS09820	COG1187	pseudouridine synthase activity
EGY22_RS09825	COG0779	Required for maturation of 30S ribosomal subunits
EGY22_RS09830	COG2251	uridine kinase activity
EGY22_RS09830	COG0195	Participates in both transcription termination and antitermination
EGY22_RS09840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGY22_RS09845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGY22_RS09850	COG1217	gtp-binding protein TYPA
EGY22_RS09855	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_RS09865	COG4160	amino acid transport
EGY22_RS09870	COG4215	(ABC) transporter
EGY22_RS09890	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGY22_RS09900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGY22_RS09915	COG0501	Belongs to the peptidase M48B family
EGY22_RS09930	COG1722	exodeoxyribonuclease VII activity
EGY22_RS09935	COG0142	geranyltranstransferase activity
EGY22_RS09945	COG1469	GTP cyclohydrolase I activity
EGY22_RS09950	COG0360	Binds together with S18 to 16S ribosomal RNA
EGY22_RS09955	COG2965	DNA replication, synthesis of RNA primer
EGY22_RS09960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGY22_RS09970	COG0305	Participates in initiation and elongation during chromosome replication
EGY22_RS09980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGY22_RS09985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EGY22_RS09990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGY22_RS10000	COG0436	Aminotransferase
EGY22_RS10015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY22_RS10020	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EGY22_RS10025	COG1562	ergosterol biosynthetic process
EGY22_RS10030	COG1562	ergosterol biosynthetic process
EGY22_RS10035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGY22_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS10065	COG3842	ATPase activity
EGY22_RS10070	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGY22_RS10075	COG1177	transmembrane transport
EGY22_RS10080	COG1393	Belongs to the ArsC family
EGY22_RS10085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EGY22_RS10090	COG0704	Plays a role in the regulation of phosphate uptake
EGY22_RS10095	COG2203	Gaf domain
EGY22_RS10095	COG3706	GGDEF domain
EGY22_RS10095	COG5001	Diguanylate cyclase
EGY22_RS10095	COG4251	negative regulation of phosphorylation
EGY22_RS10100	COG0659	secondary active sulfate transmembrane transporter activity
EGY22_RS10105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EGY22_RS10110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGY22_RS10110	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EGY22_RS10115	COG1643	Atp-dependent helicase
EGY22_RS10125	COG0438	transferase activity, transferring glycosyl groups
EGY22_RS10130	COG0726	polysaccharide deacetylase
EGY22_RS10145	COG0438	transferase activity, transferring glycosyl groups
EGY22_RS10170	COG1132	(ABC) transporter
EGY22_RS10225	COG2186	Transcriptional regulator
EGY22_RS10230	COG0277	FAD linked oxidase domain protein
EGY22_RS10235	COG0277	FAD linked oxidase domain protein
EGY22_RS10240	COG0247	lactate metabolic process
EGY22_RS10265	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS10315	COG0628	permease
EGY22_RS10320	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGY22_RS10335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS10345	COG0697	spore germination
EGY22_RS10365	COG3094	Invasion gene expression up-regulator, SirB
EGY22_RS10375	COG0640	Transcriptional regulator
EGY22_RS10400	COG0659	secondary active sulfate transmembrane transporter activity
EGY22_RS10405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_RS10415	COG2314	TM2 domain
EGY22_RS10420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGY22_RS10425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGY22_RS10430	COG0791	NLP P60 protein
EGY22_RS10450	COG1360	Flagellar Motor Protein
EGY22_RS10460	COG0835	chemotaxis
EGY22_RS10465	COG0840	transmembrane signaling receptor activity
EGY22_RS10470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EGY22_RS10480	COG0745	RESPONSE REGULATOR receiver
EGY22_RS10485	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EGY22_RS10495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY22_RS10505	COG3550	peptidyl-serine autophosphorylation
EGY22_RS10530	COG1815	bacterial-type flagellum-dependent cell motility
EGY22_RS10535	COG1558	bacterial-type flagellum-dependent cell motility
EGY22_RS10540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EGY22_RS10580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGY22_RS10605	COG2176	DNA-directed DNA polymerase activity
EGY22_RS10615	COG1987	bacterial-type flagellum assembly
EGY22_RS10630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGY22_RS10655	COG1157	protein secretion by the type III secretion system
EGY22_RS10670	COG1766	The M ring may be actively involved in energy transduction
EGY22_RS10675	COG1677	Flagellar hook-basal body complex protein FliE
EGY22_RS10680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGY22_RS10705	COG1334	flagellar protein FlaG
EGY22_RS10710	COG1191	sigma factor activity
EGY22_RS10735	COG0582	viral genome integration into host DNA
EGY22_RS10805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_RS10825	COG2733	membrane
EGY22_RS10830	COG0840	transmembrane signaling receptor activity
EGY22_RS10835	COG0840	transmembrane signaling receptor activity
EGY22_RS10860	COG2610	gluconate transmembrane transporter activity
EGY22_RS10885	COG4974	Belongs to the 'phage' integrase family
EGY22_RS10945	COG4128	Pfam Zonular occludens toxin
EGY22_RS10990	COG1538	Outer membrane efflux protein
EGY22_RS10995	COG4521	taurine ABC transporter
EGY22_RS11000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EGY22_RS11005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS11015	COG0583	DNA-binding transcription factor activity
EGY22_RS11020	COG2824	Alkylphosphonate utilization operon protein PhnA
EGY22_RS11030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS11060	COG1192	Involved in chromosome partitioning
EGY22_RS11070	COG1113	amino acid transport
EGY22_RS11090	COG0583	DNA-binding transcription factor activity
EGY22_RS11095	COG3755	Protein conserved in bacteria
EGY22_RS11100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGY22_RS11135	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_RS11160	COG1278	Cold shock
EGY22_RS11165	COG0642	Histidine kinase
EGY22_RS11175	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_RS11185	COG2863	cytochrome
EGY22_RS11190	COG3258	Cytochrome c
EGY22_RS11245	COG0025	NhaP-type Na H and K H
EGY22_RS11260	COG1289	transmembrane transporter activity
EGY22_RS11265	COG2252	PERMEase
EGY22_RS11285	COG1999	signal sequence binding
EGY22_RS11295	COG0069	glutamate synthase activity
EGY22_RS11305	COG1846	Transcriptional regulator
EGY22_RS11315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGY22_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS11365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EGY22_RS11365	COG3264	Mechanosensitive ion channel
EGY22_RS11370	COG1511	domain protein
EGY22_RS11370	COG3264	Mechanosensitive ion channel
EGY22_RS11375	COG0477	Major facilitator Superfamily
EGY22_RS11390	COG1396	sequence-specific DNA binding
EGY22_RS11395	COG3437	response regulator, receiver
EGY22_RS11400	COG2205	protein histidine kinase activity
EGY22_RS11400	COG2198	Histidine kinase
EGY22_RS11400	COG0784	Response regulator, receiver
EGY22_RS11405	COG2239	Acts as a magnesium transporter
EGY22_RS11415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EGY22_RS11420	COG1490	D-aminoacyl-tRNA deacylase activity
EGY22_RS11435	COG0456	acetyltransferase
EGY22_RS11445	COG0501	Belongs to the peptidase M48B family
EGY22_RS11450	COG2814	Major facilitator Superfamily
EGY22_RS11515	COG3706	GGDEF domain
EGY22_RS11530	COG1522	sequence-specific DNA binding
EGY22_RS11535	COG0626	cystathionine gamma-synthase activity
EGY22_RS11545	COG0494	nUDIX hydrolase
EGY22_RS11550	COG2832	Protein of unknown function (DUF454)
EGY22_RS11560	COG0137	argininosuccinate synthase activity
EGY22_RS11565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGY22_RS11570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_RS11590	COG1609	Transcriptional regulator
EGY22_RS11600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EGY22_RS11610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EGY22_RS11615	COG2205	protein histidine kinase activity
EGY22_RS11620	COG0745	RESPONSE REGULATOR receiver
EGY22_RS11625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGY22_RS11635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_RS11640	COG0268	Binds directly to 16S ribosomal RNA
EGY22_RS11645	COG0728	peptidoglycan biosynthetic process
EGY22_RS11655	COG0563	adenylate kinase activity
EGY22_RS11660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EGY22_RS11665	COG2835	tetraacyldisaccharide 4'-kinase activity
EGY22_RS11675	COG0848	biopolymer transport protein
EGY22_RS11680	COG0811	peptide transport
EGY22_RS11685	COG1570	exodeoxyribonuclease VII activity
EGY22_RS11690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGY22_RS11700	COG0183	Belongs to the thiolase family
EGY22_RS11710	COG1278	Cold shock
EGY22_RS11715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EGY22_RS11720	COG0542	response to heat
EGY22_RS11725	COG2995	paraquat-inducible protein a
EGY22_RS11730	COG3008	intermembrane lipid transfer
EGY22_RS11730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGY22_RS11780	COG0693	protein deglycase activity
EGY22_RS11785	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EGY22_RS11790	COG0756	dUTP diphosphatase activity
EGY22_RS11800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGY22_RS11805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGY22_RS11810	COG0196	riboflavin kinase activity
EGY22_RS11815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGY22_RS11820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGY22_RS11820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGY22_RS11830	COG0210	DNA helicase
EGY22_RS11885	COG0488	(ABC) transporter
EGY22_RS11890	COG2890	protein-(glutamine-N5) methyltransferase activity
EGY22_RS11895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGY22_RS11900	COG2171	N-acyltransferase activity
EGY22_RS11910	COG2207	Transcriptional regulator
EGY22_RS11920	COG3273	potassium ion transport
EGY22_RS11920	COG0471	metal ion transport
EGY22_RS11965	COG0789	Transcriptional regulator
EGY22_RS11985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS11990	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGY22_RS11995	COG0740	serine-type endopeptidase activity
EGY22_RS12005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGY22_RS12015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGY22_RS12025	COG0556	nucleotide-excision repair
EGY22_RS12030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGY22_RS12040	COG1104	cysteine desulfurase activity
EGY22_RS12050	COG0316	Belongs to the HesB IscA family
EGY22_RS12065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGY22_RS12070	COG4221	oxidoreductase activity
EGY22_RS12080	COG0840	transmembrane signaling receptor activity
EGY22_RS12085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGY22_RS12090	COG0697	spore germination
EGY22_RS12095	COG0385	Bile acid
EGY22_RS12105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGY22_RS12120	COG1136	(ABC) transporter
EGY22_RS12125	COG0084	hydrolase, TatD family'
EGY22_RS12140	COG0613	PHP domain protein
EGY22_RS12150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGY22_RS12150	COG0047	phosphoribosylformylglycinamidine synthase activity
EGY22_RS12175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY22_RS12175	COG0519	Catalyzes the synthesis of GMP from XMP
EGY22_RS12180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGY22_RS12190	COG3311	Transcriptional regulator
EGY22_RS12205	COG2076	Multidrug Resistance protein
EGY22_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS12215	COG0583	DNA-binding transcription factor activity
EGY22_RS12230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGY22_RS12240	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS12245	COG0523	cobalamin synthesis protein
EGY22_RS12250	COG1469	GTP cyclohydrolase I activity
EGY22_RS12255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGY22_RS12265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGY22_RS12270	COG0735	belongs to the Fur family
EGY22_RS12275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGY22_RS12295	COG0745	RESPONSE REGULATOR receiver
EGY22_RS12300	COG2207	Transcriptional regulator
EGY22_RS12320	COG0583	DNA-binding transcription factor activity
EGY22_RS12325	COG1289	transmembrane transporter activity
EGY22_RS12335	COG1566	PFAM secretion protein HlyD family protein
EGY22_RS12345	COG1942	4-Oxalocrotonate Tautomerase
EGY22_RS12360	COG3162	membrane
EGY22_RS12365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_RS12375	COG2070	2-Nitropropane dioxygenase
EGY22_RS12400	COG1309	transcriptional regulator
EGY22_RS12415	COG0625	glutathione transferase activity
EGY22_RS12420	COG0583	DNA-binding transcription factor activity
EGY22_RS12440	COG0625	glutathione transferase activity
EGY22_RS12445	COG0740	serine-type endopeptidase activity
EGY22_RS12495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGY22_RS12505	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS12525	COG0640	Transcriptional regulator
EGY22_RS12550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_RS12580	COG3485	protocatechuate 3,4-dioxygenase
EGY22_RS12590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EGY22_RS12595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_RS12605	COG3135	benzoate transporter
EGY22_RS12610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGY22_RS12615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EGY22_RS12625	COG4555	ABC transporter
EGY22_RS12635	COG2197	response regulator
EGY22_RS12640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGY22_RS12665	COG1846	Transcriptional regulator
EGY22_RS12670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_RS12675	COG2271	Major facilitator Superfamily
EGY22_RS12685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGY22_RS12695	COG0697	spore germination
EGY22_RS12725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGY22_RS12730	COG0667	Aldo Keto reductase
EGY22_RS12745	COG0582	viral genome integration into host DNA
EGY22_RS12785	COG0629	single-stranded DNA binding
EGY22_RS13020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EGY22_RS13095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGY22_RS13100	COG1335	isochorismatase
EGY22_RS13110	COG2135	peptidase activity
EGY22_RS13125	COG1272	protein, Hemolysin III
EGY22_RS13130	COG3422	double-strand break repair
EGY22_RS13150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS13155	COG0765	amino acid transport
EGY22_RS13160	COG0765	amino acid transport
EGY22_RS13165	COG1126	abc transporter atp-binding protein
EGY22_RS13220	COG2871	sodium ion transport
EGY22_RS13250	COG2814	Major facilitator Superfamily
EGY22_RS13255	COG1280	lysine exporter protein (LysE YggA)
EGY22_RS13275	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_RS13300	COG0330	HflC and HflK could
EGY22_RS13305	COG1585	Membrane protein implicated in regulation of membrane protease activity
EGY22_RS13310	COG2226	methyltransferase
EGY22_RS13320	COG3042	response to heat
EGY22_RS13330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGY22_RS13340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGY22_RS13345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EGY22_RS13360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGY22_RS13365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGY22_RS13395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGY22_RS13400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGY22_RS13405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGY22_RS13410	COG0072	phenylalanine-tRNA ligase activity
EGY22_RS13410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGY22_RS13425	COG2833	Protein of unknown function (DUF455)
EGY22_RS13440	COG5265	(ABC) transporter
EGY22_RS13445	COG1959	2 iron, 2 sulfur cluster binding
EGY22_RS13450	COG0719	Fe-S assembly protein
EGY22_RS13455	COG0396	ATPase activity
EGY22_RS13460	COG0719	Fe-S assembly protein
EGY22_RS13470	COG0822	iron-sulfur transferase activity
EGY22_RS13475	COG2151	metal-sulfur cluster biosynthetic enzyme
EGY22_RS13490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGY22_RS13545	COG3048	D-serine ammonia-lyase activity
EGY22_RS13550	COG3258	Cytochrome c
EGY22_RS13565	COG3949	Membrane
EGY22_RS13580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGY22_RS13595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGY22_RS13600	COG0569	domain protein
EGY22_RS13605	COG1902	pentaerythritol trinitrate reductase activity
EGY22_RS13615	COG1610	YqeY-like protein
EGY22_RS13620	COG0587	DNA-directed DNA polymerase activity
EGY22_RS13655	COG3181	Tripartite tricarboxylate transporter family receptor
EGY22_RS13660	COG0583	DNA-binding transcription factor activity
EGY22_RS13665	COG1686	Belongs to the peptidase S11 family
EGY22_RS13680	COG1360	Flagellar Motor Protein
EGY22_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS13700	COG4221	oxidoreductase activity
EGY22_RS13705	COG0307	riboflavin synthase, alpha
EGY22_RS13720	COG1301	dicarboxylic acid transport
EGY22_RS13725	COG4191	Histidine kinase
EGY22_RS13770	COG2233	PERMEase
EGY22_RS13775	COG0071	Belongs to the small heat shock protein (HSP20) family
EGY22_RS13780	COG1473	amidohydrolase
EGY22_RS13790	COG2814	Major facilitator Superfamily
EGY22_RS13820	COG2816	NAD+ diphosphatase activity
EGY22_RS13825	COG1561	YicC-like family, N-terminal region
EGY22_RS13840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGY22_RS13845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGY22_RS13850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGY22_RS13855	COG0174	glutamine synthetase
EGY22_RS13860	COG2153	protein acetylation
EGY22_RS13880	COG3842	ATPase activity
EGY22_RS13885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_RS13890	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_RS13905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGY22_RS13915	COG0783	Belongs to the Dps family
EGY22_RS13925	COG3842	ATPase activity
EGY22_RS13930	COG0395	ABC-type sugar transport system, permease component
EGY22_RS13935	COG1175	transmembrane transport
EGY22_RS13940	COG1653	transport
EGY22_RS13955	COG0559	Belongs to the binding-protein-dependent transport system permease family
EGY22_RS13975	COG0625	glutathione transferase activity
EGY22_RS13985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGY22_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS13995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGY22_RS14000	COG0114	fumarate hydratase activity
EGY22_RS14005	COG2133	pyrroloquinoline quinone binding
EGY22_RS14010	COG2226	methyltransferase
EGY22_RS14015	COG0589	response to stress
EGY22_RS14020	COG4654	Cytochrome c, class I
EGY22_RS14025	COG2207	Transcriptional regulator
EGY22_RS14030	COG0235	Class ii aldolase
EGY22_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS14045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGY22_RS14050	COG2807	transmembrane transport
EGY22_RS14060	COG0583	DNA-binding transcription factor activity
EGY22_RS14090	COG0583	DNA-binding transcription factor activity
EGY22_RS14095	COG4974	Belongs to the 'phage' integrase family
EGY22_RS14105	COG2132	Multicopper oxidase
EGY22_RS14110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EGY22_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS14155	COG3038	cytochrome b561
EGY22_RS14165	COG2353	YceI-like domain
EGY22_RS14170	COG1393	Belongs to the ArsC family
EGY22_RS14175	COG0625	glutathione transferase activity
EGY22_RS14195	COG0084	hydrolase, TatD family'
EGY22_RS14200	COG0470	DNA polymerase III
EGY22_RS14210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGY22_RS14230	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS14235	COG2914	Belongs to the UPF0125 (RnfH) family
EGY22_RS14240	COG2867	negative regulation of translational initiation
EGY22_RS14245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGY22_RS14250	COG1252	NADH dehydrogenase
EGY22_RS14275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY22_RS14280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGY22_RS14285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY22_RS14295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGY22_RS14300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGY22_RS14310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_RS14320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EGY22_RS14325	COG0575	Belongs to the CDS family
EGY22_RS14330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGY22_RS14335	COG0233	cytoplasmic translational termination
EGY22_RS14340	COG0528	UMP kinase activity
EGY22_RS14345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGY22_RS14350	COG0052	Belongs to the universal ribosomal protein uS2 family
EGY22_RS14355	COG0024	Methionine aminopeptidase
EGY22_RS14360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EGY22_RS14385	COG1286	toxin biosynthetic process
EGY22_RS14395	COG0285	dihydrofolate synthase activity
EGY22_RS14400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGY22_RS14405	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGY22_RS14410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGY22_RS14425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGY22_RS14435	COG1999	signal sequence binding
EGY22_RS14445	COG0640	Transcriptional regulator
EGY22_RS14460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS14465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGY22_RS14470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGY22_RS14475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGY22_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS14505	COG0183	Belongs to the thiolase family
EGY22_RS14525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGY22_RS14535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_RS14540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_RS14545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EGY22_RS14570	COG0183	Belongs to the thiolase family
EGY22_RS14580	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EGY22_RS14610	COG0194	GDP metabolic process
EGY22_RS14615	COG1758	RNA polymerase activity
EGY22_RS14620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY22_RS14630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EGY22_RS14635	COG0739	heme binding
EGY22_RS14640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_RS14645	COG0584	glycerophosphoryl diester phosphodiesterase
EGY22_RS14650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EGY22_RS14655	COG1187	pseudouridine synthase activity
EGY22_RS14660	COG3161	chorismate lyase activity
EGY22_RS14665	COG2814	Major facilitator Superfamily
EGY22_RS14670	COG0656	L-ascorbic acid biosynthetic process
EGY22_RS14680	COG0668	transmembrane transport
EGY22_RS14685	COG0165	Argininosuccinate lyase
EGY22_RS14700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS14710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGY22_RS14720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGY22_RS14725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EGY22_RS14730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGY22_RS14735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGY22_RS14740	COG2252	PERMEase
EGY22_RS14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_RS14765	COG0488	(ABC) transporter
EGY22_RS14770	COG1619	proteins homologs of microcin C7 resistance protein MccF
EGY22_RS14780	COG1131	(ABC) transporter
EGY22_RS14785	COG0842	Transport permease protein
EGY22_RS14795	COG1666	GTP binding
EGY22_RS14800	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_RS14805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGY22_RS14810	COG0519	Catalyzes the synthesis of GMP from XMP
EGY22_RS14810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGY22_RS14815	COG2207	Transcriptional regulator
EGY22_RS14825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGY22_RS14830	COG0135	phosphoribosylanthranilate isomerase activity
EGY22_RS14835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EGY22_RS14845	COG0101	tRNA pseudouridine synthase activity
EGY22_RS14855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGY22_RS14880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGY22_RS14890	COG4566	intracellular signal transduction
EGY22_RS14905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGY22_RS14910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGY22_RS14920	COG1295	ribonuclease BN
EGY22_RS14930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGY22_RS14965	COG4964	Belongs to the GSP D family
EGY22_RS15010	COG2959	enzyme of heme biosynthesis
EGY22_RS15020	COG0181	hydroxymethylbilane synthase activity
EGY22_RS15025	COG0861	Integral membrane protein TerC family
EGY22_RS15030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGY22_RS15035	COG0045	succinate-CoA ligase (ADP-forming) activity
EGY22_RS15045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGY22_RS15050	COG0583	DNA-binding transcription factor activity
EGY22_RS15055	COG2137	regulation of response to DNA damage stimulus
EGY22_RS15060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGY22_RS15075	COG0477	Major facilitator Superfamily
EGY22_RS15090	COG0318	PFAM AMP-dependent synthetase and ligase
EGY22_RS15095	COG1024	Enoyl-CoA hydratase
EGY22_RS15100	COG3162	membrane
EGY22_RS15115	COG0540	Belongs to the ATCase OTCase family
EGY22_RS15130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGY22_RS15145	COG2070	2-Nitropropane dioxygenase
EGY22_RS15155	COG2111	Na H antiporter
EGY22_RS15155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGY22_RS15160	COG1006	Multisubunit Na H antiporter MnhC subunit
EGY22_RS15165	COG0651	ATP synthesis coupled electron transport
EGY22_RS15175	COG2212	antiporter activity
EGY22_RS15190	COG0477	Major facilitator Superfamily
EGY22_RS15215	COG3158	transport of potassium into the cell
EGY22_RS15220	COG0642	Histidine kinase
EGY22_RS15245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGY22_RS15250	COG4208	sulfate ABC transporter
EGY22_RS15255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGY22_RS15260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGY22_RS15275	COG1278	Cold shock
EGY22_RS15395	COG0740	serine-type endopeptidase activity
EGY22_RS15495	COG1396	sequence-specific DNA binding
EGY22_RS15595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_RS15595	COG1648	precorrin-2 dehydrogenase activity
EGY22_RS15605	COG3391	amine dehydrogenase activity
EGY22_RS15625	COG0535	radical SAM domain protein
EGY22_RS15630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGY22_RS15630	COG1648	precorrin-2 dehydrogenase activity
EGY22_RS15640	COG2010	Cytochrome c
EGY22_RS15645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS15650	COG0626	cystathionine gamma-synthase activity
EGY22_RS15655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGY22_RS15660	COG0557	exoribonuclease II activity
EGY22_RS15680	COG0765	amino acid transport
EGY22_RS15685	COG0765	amino acid transport
EGY22_RS15690	COG1126	abc transporter atp-binding protein
EGY22_RS15705	COG1850	ribulose-bisphosphate carboxylase activity
EGY22_RS15725	COG2375	cellular response to nickel ion
EGY22_RS15755	COG0583	DNA-binding transcription factor activity
EGY22_RS15760	COG3842	ATPase activity
EGY22_RS15765	COG1175	transmembrane transport
EGY22_RS15770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGY22_RS15775	COG1840	ABC-type Fe3 transport system, periplasmic component
EGY22_RS15795	COG0412	Dienelactone hydrolase
EGY22_RS15800	COG3530	Putative quorum-sensing-regulated virulence factor
EGY22_RS15805	COG0625	glutathione transferase activity
EGY22_RS15810	COG1741	Belongs to the pirin family
EGY22_RS15820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGY22_RS15825	COG2814	Major facilitator Superfamily
EGY22_RS15830	COG2807	transmembrane transport
EGY22_RS15835	COG2207	Transcriptional regulator
EGY22_RS15840	COG3135	benzoate transporter
EGY22_RS15865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EGY22_RS15875	COG0402	S-adenosylhomocysteine deaminase activity
EGY22_RS15885	COG0745	RESPONSE REGULATOR receiver
EGY22_RS15890	COG2205	protein histidine kinase activity
EGY22_RS15905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EGY22_RS15910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EGY22_RS15915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGY22_RS15925	COG0330	HflC and HflK could
EGY22_RS15930	COG0330	HflC and HflK could
EGY22_RS15935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGY22_RS15940	COG1923	regulation of RNA biosynthetic process
EGY22_RS15950	COG1160	GTP binding
EGY22_RS15955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_RS15960	COG2976	Protein conserved in bacteria
EGY22_RS15980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGY22_RS15985	COG0105	UTP biosynthetic process
EGY22_RS15995	COG0336	Belongs to the RNA methyltransferase TrmD family
EGY22_RS16005	COG0228	four-way junction DNA binding
EGY22_RS16010	COG0425	Belongs to the sulfur carrier protein TusA family
EGY22_RS16015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGY22_RS16030	COG2351	hydroxyisourate hydrolase activity
EGY22_RS16065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGY22_RS16090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EGY22_RS16095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGY22_RS16120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGY22_RS16125	COG0601	transmembrane transport
EGY22_RS16155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EGY22_RS16160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGY22_RS16165	COG0542	response to heat
EGY22_RS16170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGY22_RS16185	COG0348	domain, Protein
EGY22_RS16205	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_RS16215	COG2217	Heavy metal translocating P-type atpase
EGY22_RS16220	COG2224	Isocitrate lyase
EGY22_RS16225	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY22_RS16225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGY22_RS16245	COG1472	Belongs to the glycosyl hydrolase 3 family
EGY22_RS16250	COG0736	holo-[acyl-carrier-protein] synthase activity
EGY22_RS16260	COG2050	protein possibly involved in aromatic compounds catabolism
EGY22_RS16265	COG1024	Enoyl-CoA hydratase
EGY22_RS16270	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS16275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGY22_RS16280	COG2151	metal-sulfur cluster biosynthetic enzyme
EGY22_RS16285	COG3396	Phenylacetate-CoA oxygenase
EGY22_RS16290	COG3460	Phenylacetate-CoA oxygenase
EGY22_RS16295	COG3396	Phenylacetate-CoA oxygenase
EGY22_RS16300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGY22_RS16305	COG0501	Belongs to the peptidase M48B family
EGY22_RS16310	COG1162	GTPase activity
EGY22_RS16320	COG0335	large ribosomal subunit rRNA binding
EGY22_RS16340	COG0450	alkyl hydroperoxide reductase
EGY22_RS16345	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS16365	COG2951	lytic endotransglycosylase activity
EGY22_RS16375	COG1596	polysaccharide export
EGY22_RS16375	COG1555	photosystem II stabilization
EGY22_RS16380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGY22_RS16385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGY22_RS16390	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EGY22_RS16410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGY22_RS16415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGY22_RS16420	COG0287	Prephenate dehydrogenase
EGY22_RS16430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EGY22_RS16445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGY22_RS16465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGY22_RS16475	COG4771	TonB-dependent receptor
EGY22_RS16490	COG0753	catalase activity
EGY22_RS16500	COG4335	DNA alkylation repair
EGY22_RS16510	COG0436	Aminotransferase
EGY22_RS16520	COG0251	oxidation-reduction process
EGY22_RS16525	COG1309	transcriptional regulator
EGY22_RS16580	COG0625	glutathione transferase activity
EGY22_RS16590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EGY22_RS16595	COG1280	lysine exporter protein (LysE YggA)
EGY22_RS16615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGY22_RS16625	COG2205	protein histidine kinase activity
EGY22_RS16625	COG2198	Histidine kinase
EGY22_RS16625	COG0784	Response regulator, receiver
EGY22_RS16630	COG2046	Belongs to the sulfate adenylyltransferase family
EGY22_RS16635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EGY22_RS16640	COG0642	Histidine kinase
EGY22_RS16650	COG0840	transmembrane signaling receptor activity
EGY22_RS16655	COG2119	membrane
EGY22_RS16670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGY22_RS16675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGY22_RS16690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGY22_RS16695	COG2321	neutral zinc metallopeptidase
EGY22_RS16705	COG2271	Major facilitator Superfamily
EGY22_RS16710	COG2175	clavaminate synthase activity
EGY22_RS16715	COG1846	Transcriptional regulator
EGY22_RS16720	COG0347	Belongs to the P(II) protein family
EGY22_RS16725	COG0004	ammonium transporteR
EGY22_RS16730	COG3909	cytochrome
EGY22_RS16740	COG0625	glutathione transferase activity
EGY22_RS16745	COG0730	response to heat
EGY22_RS16750	COG0482	sulfurtransferase activity
EGY22_RS16755	COG0277	FAD linked oxidase domain protein
EGY22_RS16760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGY22_RS16765	COG2879	small protein
EGY22_RS16770	COG1966	Carbon starvation protein
EGY22_RS16775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGY22_RS16780	COG0765	amino acid transport
EGY22_RS16785	COG0765	amino acid transport
EGY22_RS16790	COG1126	abc transporter atp-binding protein
EGY22_RS16795	COG0028	Belongs to the TPP enzyme family
EGY22_RS16800	COG1012	belongs to the aldehyde dehydrogenase family
EGY22_RS16805	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
EGY22_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS16815	COG2226	methyltransferase
EGY22_RS16815	COG0596	Alpha beta hydrolase
EGY22_RS16815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGY22_RS16820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGY22_RS16825	COG1116	anion transmembrane transporter activity
EGY22_RS16840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS16855	COG5285	phytanoyl-CoA dioxygenase
EGY22_RS16860	COG0662	Cupin 2, conserved barrel domain protein
EGY22_RS16870	COG0456	acetyltransferase
EGY22_RS16875	COG1846	Transcriptional regulator
EGY22_RS16885	COG0312	modulator of DNA gyrase
EGY22_RS16900	COG0308	aminopeptidase N
EGY22_RS16905	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EGY22_RS16920	COG0473	3-isopropylmalate dehydrogenase activity
EGY22_RS16930	COG0433	COG0433 Predicted ATPase
EGY22_RS16935	COG0217	transcriptional regulatory protein
EGY22_RS16940	COG0151	Belongs to the GarS family
EGY22_RS16950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGY22_RS16955	COG0799	negative regulation of ribosome biogenesis
EGY22_RS16960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGY22_RS16965	COG0424	maF-like protein
EGY22_RS16985	COG0023	Translation Initiation Factor
EGY22_RS16995	COG2084	Dehydrogenase
EGY22_RS17000	COG0625	glutathione transferase activity
EGY22_RS17005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EGY22_RS17010	COG1047	Peptidyl-prolyl cis-trans
EGY22_RS17015	COG2003	Belongs to the UPF0758 family
EGY22_RS17020	COG1737	Transcriptional regulator
EGY22_RS17025	COG0477	Major facilitator Superfamily
EGY22_RS17035	COG2271	Major facilitator Superfamily
EGY22_RS17050	COG0534	Mate efflux family protein
EGY22_RS17055	COG4175	Glycine betaine
EGY22_RS17060	COG4176	ABC-type proline glycine betaine transport system permease component
EGY22_RS17070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGY22_RS17075	COG2814	Major facilitator Superfamily
EGY22_RS17080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGY22_RS17085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGY22_RS17090	COG0495	leucyl-tRNA aminoacylation
EGY22_RS17100	COG1466	dna polymerase III delta subunit
EGY22_RS17105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGY22_RS17110	COG1981	membrane
EGY22_RS17130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGY22_RS17140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EGY22_RS17145	COG0148	phosphopyruvate hydratase activity
EGY22_RS17155	COG2814	Major facilitator Superfamily
EGY22_RS17170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EGY22_RS17180	COG0504	CTP synthase activity
EGY22_RS17215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGY22_RS17225	COG0791	NLP P60 protein
EGY22_RS17235	COG0583	DNA-binding transcription factor activity
EGY22_RS17245	COG0583	DNA-binding transcription factor activity
EGY22_RS17255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGY22_RS17270	COG1045	serine acetyltransferase
EGY22_RS17285	COG1381	Involved in DNA repair and RecF pathway recombination
EGY22_RS17290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGY22_RS17295	COG0571	ribonuclease III activity
EGY22_RS17310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGY22_RS17335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGY22_RS17340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGY22_RS17345	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS17350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGY22_RS17355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGY22_RS17365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGY22_RS17370	COG1399	metal-binding, possibly nucleic acid-binding protein
EGY22_RS17375	COG0424	maF-like protein
EGY22_RS17385	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGY22_RS17390	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EGY22_RS17395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGY22_RS17400	COG0546	phosphoglycolate phosphatase activity
EGY22_RS17405	COG0564	pseudouridine synthase activity
EGY22_RS17410	COG1530	ribonuclease E activity
EGY22_RS17415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGY22_RS17420	COG0159	tryptophan synthase activity
EGY22_RS17425	COG0133	tryptophan synthase activity
EGY22_RS17430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGY22_RS17440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGY22_RS17445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGY22_RS17455	COG2878	Part of a membrane complex involved in electron transport
EGY22_RS17460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGY22_RS17465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGY22_RS17470	COG3047	cAMP biosynthetic process
EGY22_RS17495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGY22_RS17500	COG2917	probably involved in intracellular septation
EGY22_RS17510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGY22_RS17515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGY22_RS17525	COG1196	nuclear chromosome segregation
EGY22_RS17535	COG1573	uracil-dna glycosylase
EGY22_RS17540	COG1214	PFAM Peptidase M22, glycoprotease
EGY22_RS17555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EGY22_RS17560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGY22_RS17565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGY22_RS17570	COG0560	Phosphoserine phosphatase
EGY22_RS17585	COG1007	ATP synthesis coupled electron transport
EGY22_RS17600	COG0713	ATP synthesis coupled electron transport
EGY22_RS17610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_RS17615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EGY22_RS17620	COG1034	ATP synthesis coupled electron transport
EGY22_RS17635	COG0649	NAD binding
EGY22_RS17640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_RS17645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_RS17650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGY22_RS17655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EGY22_RS17670	COG0149	triose-phosphate isomerase activity
EGY22_RS17675	COG0604	alcohol dehydrogenase
EGY22_RS17700	COG1185	polyribonucleotide nucleotidyltransferase activity
EGY22_RS17705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGY22_RS17710	COG1183	phosphatidylcholine synthase activity
EGY22_RS17715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGY22_RS17720	COG0440	acetolactate synthase activity
EGY22_RS17725	COG0028	Belongs to the TPP enzyme family
EGY22_RS17730	COG1289	transmembrane transporter activity
EGY22_RS17735	COG3022	response to hydroperoxide
EGY22_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS17795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGY22_RS17800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGY22_RS17805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EGY22_RS17810	COG1674	ftsk spoiiie
EGY22_RS17815	COG0492	ferredoxin-NADP+ reductase activity
EGY22_RS17835	COG0477	Major facilitator Superfamily
EGY22_RS17855	COG2272	Belongs to the type-B carboxylesterase lipase family
EGY22_RS17860	COG1960	acyl-CoA dehydrogenase activity
EGY22_RS17885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGY22_RS17905	COG2204	response regulator
EGY22_RS17945	COG4964	Belongs to the GSP D family
EGY22_RS18005	COG0612	Peptidase, M16
EGY22_RS18010	COG0484	heat shock protein binding
EGY22_RS18015	COG0443	Heat shock 70 kDa protein
EGY22_RS18020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGY22_RS18025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGY22_RS18030	COG1420	regulation of RNA biosynthetic process
EGY22_RS18040	COG0497	DNA recombination
EGY22_RS18045	COG0735	belongs to the Fur family
EGY22_RS18050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGY22_RS18055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGY22_RS18080	COG0477	Major facilitator Superfamily
EGY22_RS18105	COG3122	Protein conserved in bacteria
EGY22_RS18115	COG3039	Transposase
EGY22_RS18125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGY22_RS18155	COG1538	Outer membrane efflux protein
EGY22_RS18175	COG2271	Major facilitator Superfamily
EGY22_RS18195	COG2814	Major facilitator Superfamily
EGY22_RS18210	COG2819	hydrolase of the alpha beta superfamily
EGY22_RS18230	COG1454	alcohol dehydrogenase
EGY22_RS18240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGY22_RS18265	COG1414	Transcriptional regulator
EGY22_RS18270	COG0513	Belongs to the DEAD box helicase family
EGY22_RS18275	COG3657	addiction module killer protein
EGY22_RS18280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGY22_RS18285	COG0583	DNA-binding transcription factor activity
EGY22_RS18290	COG4638	Rieske (2fe-2S)
EGY22_RS18295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EGY22_RS18310	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGY22_RS18325	COG3971	2-oxopent-4-enoate hydratase activity
EGY22_RS18330	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EGY22_RS18335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGY22_RS18340	COG2814	Major facilitator Superfamily
EGY22_RS18355	COG0154	amidase activity
EGY22_RS18365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS18370	COG2814	Major facilitator Superfamily
EGY22_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
EGY22_RS18405	COG0842	Transport permease protein
EGY22_RS18410	COG1129	ABC transporter
EGY22_RS18410	COG0842	Transport permease protein
EGY22_RS18415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGY22_RS18425	COG3243	poly(R)-hydroxyalkanoic acid synthase
EGY22_RS18435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EGY22_RS18440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGY22_RS18445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_RS18460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGY22_RS18475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EGY22_RS18480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EGY22_RS18490	COG0789	Transcriptional regulator
EGY22_RS18500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGY22_RS18545	COG3278	Belongs to the heme-copper respiratory oxidase family
EGY22_RS18550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGY22_RS18570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGY22_RS18615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGY22_RS18680	COG0517	IMP dehydrogenase activity
EGY22_RS18680	COG0516	GMP reductase activity
EGY22_RS18695	COG1027	Aspartate ammonia-lyase
EGY22_RS18700	COG1846	Transcriptional regulator
EGY22_RS18715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGY22_RS18720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EGY22_RS18735	COG1414	Transcriptional regulator
EGY22_RS18755	COG0513	Belongs to the DEAD box helicase family
EGY22_RS18775	COG0429	hydrolase of the alpha beta-hydrolase fold