locus-tag	class	description
AFA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFA_RS00010	COG0592	DNA-directed DNA polymerase activity
AFA_RS00030	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS00035	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS00045	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS00050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFA_RS00065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS00085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFA_RS00090	COG0583	DNA-binding transcription factor activity
AFA_RS00100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AFA_RS00110	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS00125	COG0318	PFAM AMP-dependent synthetase and ligase
AFA_RS00135	COG0596	Alpha beta hydrolase
AFA_RS00135	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFA_RS00140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS00155	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS00165	COG0697	spore germination
AFA_RS00170	COG0583	DNA-binding transcription factor activity
AFA_RS00180	COG3842	ATPase activity
AFA_RS00190	COG0436	Aminotransferase
AFA_RS00200	COG0523	cobalamin synthesis protein
AFA_RS00260	COG1846	Transcriptional regulator
AFA_RS00280	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFA_RS00285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFA_RS00290	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AFA_RS00300	COG4638	Rieske (2fe-2S)
AFA_RS00330	COG0477	Major facilitator Superfamily
AFA_RS00335	COG0789	Transcriptional regulator
AFA_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS00375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFA_RS00390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFA_RS00410	COG4608	Belongs to the ABC transporter superfamily
AFA_RS00415	COG0444	Belongs to the ABC transporter superfamily
AFA_RS00420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFA_RS00425	COG0601	transmembrane transport
AFA_RS00435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFA_RS00440	COG1595	DNA-templated transcription, initiation
AFA_RS00445	COG3712	iron ion homeostasis
AFA_RS00450	COG4774	siderophore transport
AFA_RS00455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFA_RS00460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFA_RS00475	COG1464	Belongs to the NlpA lipoprotein family
AFA_RS00480	COG1464	Belongs to the NlpA lipoprotein family
AFA_RS00485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFA_RS00490	COG2011	ABC-type metal ion transport system permease component
AFA_RS00520	COG1464	Belongs to the NlpA lipoprotein family
AFA_RS00535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFA_RS00540	COG0431	NADPH-dependent FMN reductase
AFA_RS00570	COG4149	molybdate abc transporter
AFA_RS00580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFA_RS00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFA_RS00595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS00615	COG0028	Belongs to the TPP enzyme family
AFA_RS00620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS00660	COG2922	Belongs to the Smg family
AFA_RS00675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFA_RS00680	COG0183	Belongs to the thiolase family
AFA_RS00685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AFA_RS00690	COG1960	acyl-CoA dehydrogenase activity
AFA_RS00710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFA_RS00720	COG0018	arginyl-trna synthetase
AFA_RS00750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFA_RS00760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AFA_RS00765	COG4774	siderophore transport
AFA_RS00770	COG0066	3-isopropylmalate dehydratase activity
AFA_RS00775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFA_RS00780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFA_RS00785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFA_RS00790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS00790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AFA_RS00800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS00805	COG1335	isochorismatase
AFA_RS00810	COG0583	DNA-binding transcription factor activity
AFA_RS00830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AFA_RS00835	COG1280	lysine exporter protein (LysE YggA)
AFA_RS00840	COG0513	Belongs to the DEAD box helicase family
AFA_RS00850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AFA_RS00865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFA_RS00915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFA_RS00920	COG1127	ABC transporter
AFA_RS00940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFA_RS00945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS00955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS00990	COG0583	DNA-binding transcription factor activity
AFA_RS01015	COG1254	Belongs to the acylphosphatase family
AFA_RS01025	COG2358	TRAP transporter, solute receptor (TAXI family
AFA_RS01035	COG0564	pseudouridine synthase activity
AFA_RS01040	COG0252	asparaginase activity
AFA_RS01065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFA_RS01070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFA_RS01075	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS01095	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS01135	COG0758	DNA mediated transformation
AFA_RS01140	COG0242	peptide deformylase activity
AFA_RS01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFA_RS01150	COG0697	spore germination
AFA_RS01165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS01180	COG4336	lyase activity
AFA_RS01185	COG0583	DNA-binding transcription factor activity
AFA_RS01190	COG0859	PFAM glycosyl transferase family 9
AFA_RS01200	COG1278	Cold shock
AFA_RS01205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFA_RS01210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFA_RS01215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AFA_RS01215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AFA_RS01225	COG1686	Belongs to the peptidase S11 family
AFA_RS01235	COG2921	Belongs to the UPF0250 family
AFA_RS01240	COG0321	lipoyl(octanoyl) transferase activity
AFA_RS01245	COG1024	Enoyl-CoA hydratase
AFA_RS01250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFA_RS01260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFA_RS01310	COG0826	peptidase U32
AFA_RS01320	COG3154	lipid carrier protein
AFA_RS01345	COG0134	indole-3-glycerol-phosphate synthase activity
AFA_RS01350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFA_RS01355	COG0512	Glutamine amidotransferase of anthranilate synthase
AFA_RS01365	COG0546	phosphoglycolate phosphatase activity
AFA_RS01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFA_RS01380	COG2967	ApaG domain
AFA_RS01390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFA_RS01395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFA_RS01405	COG0840	transmembrane signaling receptor activity
AFA_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS01420	COG1535	isochorismatase
AFA_RS01420	COG3433	isochorismatase activity
AFA_RS01425	COG1169	isochorismate synthase
AFA_RS01440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFA_RS01445	COG1535	isochorismatase
AFA_RS01445	COG3433	isochorismatase activity
AFA_RS01450	COG1021	2,3-dihydroxybenzoate-AMP ligase
AFA_RS01465	COG0411	ABC transporter
AFA_RS01480	COG0683	leucine binding
AFA_RS01495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFA_RS01530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AFA_RS01535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFA_RS01540	COG2819	hydrolase of the alpha beta superfamily
AFA_RS01545	COG0513	Belongs to the DEAD box helicase family
AFA_RS01550	COG2814	Major facilitator Superfamily
AFA_RS01570	COG1253	flavin adenine dinucleotide binding
AFA_RS01595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFA_RS01600	COG2311	Membrane
AFA_RS01625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFA_RS01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFA_RS01650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFA_RS01660	COG0583	DNA-binding transcription factor activity
AFA_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS01670	COG1126	abc transporter atp-binding protein
AFA_RS01675	COG0765	amino acid transport
AFA_RS01680	COG0765	amino acid transport
AFA_RS01685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFA_RS01690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFA_RS01705	COG3391	amine dehydrogenase activity
AFA_RS01715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFA_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFA_RS01745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFA_RS01750	COG0210	DNA helicase
AFA_RS01770	COG0070	glutamate synthase
AFA_RS01770	COG0069	glutamate synthase activity
AFA_RS01770	COG0067	glutamate synthase
AFA_RS01775	COG1024	Enoyl-CoA hydratase
AFA_RS01785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFA_RS01790	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFA_RS01815	COG2918	glutathione biosynthetic process
AFA_RS01825	COG2197	response regulator
AFA_RS01830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFA_RS01840	COG2223	nitrite transmembrane transporter activity
AFA_RS01845	COG2860	membrane
AFA_RS01850	COG1346	cytolysis
AFA_RS01865	COG0251	oxidation-reduction process
AFA_RS01885	COG0745	RESPONSE REGULATOR receiver
AFA_RS01900	COG1280	lysine exporter protein (LysE YggA)
AFA_RS01905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFA_RS01920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFA_RS01935	COG2096	Adenosyltransferase
AFA_RS01950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFA_RS01955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFA_RS01970	COG0523	cobalamin synthesis protein
AFA_RS01975	COG0735	belongs to the Fur family
AFA_RS01985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFA_RS01990	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFA_RS01995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFA_RS02005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFA_RS02010	COG1560	Kdo2-lipid A biosynthetic process
AFA_RS02020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFA_RS02025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFA_RS02030	COG1950	PFAM Membrane protein of
AFA_RS02065	COG0275	rRNA processing
AFA_RS02070	COG0730	response to heat
AFA_RS02075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFA_RS02080	COG0129	dihydroxy-acid dehydratase activity
AFA_RS02090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS02100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS02115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFA_RS02135	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS02145	COG0628	permease
AFA_RS02155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFA_RS02165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFA_RS02190	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS02195	COG1846	Transcriptional regulator
AFA_RS02210	COG0277	FAD linked oxidase domain protein
AFA_RS02215	COG1304	FMN binding
AFA_RS02220	COG2186	Transcriptional regulator
AFA_RS02235	COG2188	Transcriptional regulator
AFA_RS02240	COG1522	sequence-specific DNA binding
AFA_RS02250	COG1113	amino acid transport
AFA_RS02255	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AFA_RS02260	COG1349	DNA-binding transcription factor activity
AFA_RS02280	COG0395	ABC-type sugar transport system, permease component
AFA_RS02295	COG0861	Integral membrane protein TerC family
AFA_RS02300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFA_RS02310	COG1671	Belongs to the UPF0178 family
AFA_RS02320	COG1418	mRNA catabolic process
AFA_RS02330	COG4948	Mandelate Racemase Muconate Lactonizing
AFA_RS02340	COG0477	Major facilitator Superfamily
AFA_RS02355	COG0154	amidase activity
AFA_RS02365	COG0583	DNA-binding transcription factor activity
AFA_RS02390	COG0326	Molecular chaperone. Has ATPase activity
AFA_RS02395	COG4774	siderophore transport
AFA_RS02400	COG3128	pkhd-type hydroxylase
AFA_RS02425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFA_RS02435	COG1652	LysM domain
AFA_RS02450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFA_RS02490	COG0583	DNA-binding transcription factor activity
AFA_RS02495	COG0387	Pfam Sodium calcium exchanger
AFA_RS02510	COG0477	Major facilitator Superfamily
AFA_RS02515	COG0235	Class ii aldolase
AFA_RS02525	COG3391	amine dehydrogenase activity
AFA_RS02530	COG0590	tRNA wobble adenosine to inosine editing
AFA_RS02535	COG3257	ureidoglycine aminohydrolase activity
AFA_RS02540	COG0583	DNA-binding transcription factor activity
AFA_RS02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFA_RS02550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFA_RS02550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFA_RS02560	COG0489	protein tyrosine kinase activity
AFA_RS02585	COG2081	HI0933 family
AFA_RS02590	COG0509	glycine decarboxylation via glycine cleavage system
AFA_RS02600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFA_RS02605	COG1765	OsmC-like protein
AFA_RS02610	COG3278	Belongs to the heme-copper respiratory oxidase family
AFA_RS02635	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AFA_RS02640	COG0469	pyruvate kinase activity
AFA_RS02645	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AFA_RS02655	COG2084	Dehydrogenase
AFA_RS02660	COG3622	Belongs to the hyi family
AFA_RS02665	COG3960	tartronate-semialdehyde synthase activity
AFA_RS02670	COG0583	DNA-binding transcription factor activity
AFA_RS02680	COG2233	PERMEase
AFA_RS02685	COG1942	4-Oxalocrotonate Tautomerase
AFA_RS02690	COG0235	Class ii aldolase
AFA_RS02700	COG3195	allantoin biosynthetic process
AFA_RS02700	COG3648	Uricase
AFA_RS02710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFA_RS02715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AFA_RS02730	COG0438	transferase activity, transferring glycosyl groups
AFA_RS02740	COG0438	transferase activity, transferring glycosyl groups
AFA_RS02750	COG0277	FAD linked oxidase domain protein
AFA_RS02760	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFA_RS02765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AFA_RS02775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFA_RS02785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFA_RS02795	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AFA_RS02810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFA_RS02815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFA_RS02820	COG0193	aminoacyl-tRNA hydrolase activity
AFA_RS02830	COG0012	GTP binding
AFA_RS02860	COG0488	(ABC) transporter
AFA_RS02870	COG0288	reversible hydration of carbon dioxide
AFA_RS02875	COG0583	DNA-binding transcription factor activity
AFA_RS02905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AFA_RS02915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFA_RS02920	COG3088	subunit of a heme lyase
AFA_RS02925	COG4235	cytochrome complex assembly
AFA_RS02930	COG0785	Cytochrome C biogenesis protein
AFA_RS02940	COG2169	Transcriptional regulator
AFA_RS02940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFA_RS02960	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS02970	COG0411	ABC transporter
AFA_RS02980	COG1858	cytochrome C peroxidase
AFA_RS02985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFA_RS02990	COG1959	2 iron, 2 sulfur cluster binding
AFA_RS02995	COG2346	COG2346, Truncated hemoglobins
AFA_RS03000	COG0463	Glycosyl transferase, family 2
AFA_RS03035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFA_RS03040	COG3383	formate dehydrogenase (NAD+) activity
AFA_RS03060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFA_RS03070	COG0303	'Molybdopterin
AFA_RS03075	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFA_RS03080	COG0314	molybdopterin synthase activity
AFA_RS03090	COG0315	cyclic pyranopterin monophosphate synthase activity
AFA_RS03120	COG0678	peroxiredoxin activity
AFA_RS03130	COG0697	spore germination
AFA_RS03135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFA_RS03155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS03200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFA_RS03205	COG4535	Mg2 and Co2 transporter CorC
AFA_RS03210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFA_RS03215	COG1702	phosphate starvation-inducible protein PhoH
AFA_RS03220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFA_RS03235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFA_RS03240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFA_RS03245	COG1862	Preprotein translocase
AFA_RS03250	COG0343	queuine tRNA-ribosyltransferase activity
AFA_RS03255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFA_RS03260	COG2027	D-alanyl-D-alanine carboxypeptidase
AFA_RS03265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFA_RS03275	COG4575	ribosome binding
AFA_RS03290	COG0583	DNA-binding transcription factor activity
AFA_RS03305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFA_RS03320	COG0154	amidase activity
AFA_RS03330	COG0477	Major facilitator Superfamily
AFA_RS03345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFA_RS03355	COG0436	Aminotransferase
AFA_RS03365	COG0281	malic enzyme
AFA_RS03365	COG0280	phosphate acetyltransferase
AFA_RS03375	COG2732	(Barnase) inhibitor
AFA_RS03380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFA_RS03385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFA_RS03390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFA_RS03395	COG0126	phosphoglycerate kinase activity
AFA_RS03420	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFA_RS03430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFA_RS03435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFA_RS03440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFA_RS03445	COG0009	L-threonylcarbamoyladenylate synthase
AFA_RS03450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFA_RS03460	COG2030	dehydratase
AFA_RS03460	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS03465	COG1960	acyl-CoA dehydrogenase activity
AFA_RS03475	COG0405	Gamma-glutamyltransferase
AFA_RS03485	COG0579	oxidoreductase
AFA_RS03490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFA_RS03495	COG0259	pyridoxamine-phosphate oxidase activity
AFA_RS03505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFA_RS03520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFA_RS03525	COG1215	transferase activity, transferring glycosyl groups
AFA_RS03535	COG0488	(ABC) transporter
AFA_RS03555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AFA_RS03560	COG2894	cell division
AFA_RS03570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFA_RS03580	COG1294	oxidase, subunit
AFA_RS03585	COG0038	chloride channel
AFA_RS03595	COG0514	ATP-dependent DNA helicase (RecQ)
AFA_RS03600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFA_RS03605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFA_RS03610	COG0633	Ferredoxin
AFA_RS03615	COG0488	(ABC) transporter
AFA_RS03625	COG2001	Belongs to the MraZ family
AFA_RS03630	COG0275	rRNA processing
AFA_RS03635	COG3116	cell division
AFA_RS03645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFA_RS03650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFA_RS03655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFA_RS03665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFA_RS03670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFA_RS03675	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFA_RS03680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFA_RS03695	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFA_RS03705	COG0739	heme binding
AFA_RS03705	COG1196	nuclear chromosome segregation
AFA_RS03705	COG0741	lytic transglycosylase activity
AFA_RS03710	COG0653	protein targeting
AFA_RS03720	COG2239	Acts as a magnesium transporter
AFA_RS03730	COG1473	amidohydrolase
AFA_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
AFA_RS03745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AFA_RS03745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS03760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFA_RS03765	COG2011	ABC-type metal ion transport system permease component
AFA_RS03775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS03780	COG0765	amino acid transport
AFA_RS03785	COG1126	abc transporter atp-binding protein
AFA_RS03810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFA_RS03815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFA_RS03820	COG0700	Nucleoside recognition
AFA_RS03835	COG0204	Acyl-transferase
AFA_RS03840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFA_RS03845	COG0751	glycine-tRNA ligase activity
AFA_RS03850	COG0752	glycyl-tRNA synthetase alpha subunit
AFA_RS03870	COG1309	transcriptional regulator
AFA_RS03880	COG2814	Major facilitator Superfamily
AFA_RS03890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFA_RS03895	COG0617	tRNA 3'-terminal CCA addition
AFA_RS03905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFA_RS03910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFA_RS03915	COG1953	Uracil, thiamine, allantoin
AFA_RS03920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFA_RS03925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFA_RS03930	COG0586	Pfam SNARE associated Golgi protein
AFA_RS03935	COG1477	protein flavinylation
AFA_RS03955	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFA_RS03960	COG0802	atpase or kinase
AFA_RS03970	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS03975	COG0281	malic enzyme
AFA_RS03975	COG0280	phosphate acetyltransferase
AFA_RS03980	COG0583	DNA-binding transcription factor activity
AFA_RS03985	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS03990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFA_RS04010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS04025	COG1733	regulation of RNA biosynthetic process
AFA_RS04030	COG2910	NAD(P)H-binding
AFA_RS04040	COG2223	nitrite transmembrane transporter activity
AFA_RS04045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFA_RS04050	COG4974	Belongs to the 'phage' integrase family
AFA_RS04055	COG0725	ABC transporter, periplasmic molybdate-binding protein
AFA_RS04060	COG4149	molybdate abc transporter
AFA_RS04065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AFA_RS04080	COG1074	ATP-dependent DNA helicase activity
AFA_RS04115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFA_RS04120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFA_RS04125	COG0505	Belongs to the CarA family
AFA_RS04130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFA_RS04145	COG0406	alpha-ribazole phosphatase activity
AFA_RS04150	COG2233	PERMEase
AFA_RS04155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFA_RS04160	COG1534	Rna-binding protein
AFA_RS04165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AFA_RS04170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFA_RS04175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFA_RS04180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFA_RS04190	COG0248	Ppx GppA phosphatase
AFA_RS04195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFA_RS04215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFA_RS04220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFA_RS04275	COG1368	sulfuric ester hydrolase activity
AFA_RS04305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFA_RS04310	COG3327	negative regulation of DNA-templated transcription, initiation
AFA_RS04315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFA_RS04330	COG0009	L-threonylcarbamoyladenylate synthase
AFA_RS04335	COG1994	Peptidase M50
AFA_RS04340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFA_RS04345	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AFA_RS04360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFA_RS04370	COG0156	8-amino-7-oxononanoate synthase activity
AFA_RS04375	COG2124	cytochrome p450
AFA_RS04380	COG3135	benzoate transporter
AFA_RS04385	COG2850	peptidyl-arginine hydroxylation
AFA_RS04390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AFA_RS04395	COG3391	amine dehydrogenase activity
AFA_RS04410	COG1136	(ABC) transporter
AFA_RS04410	COG0577	efflux transmembrane transporter activity
AFA_RS04415	COG1538	Outer membrane efflux protein
AFA_RS04420	COG0363	glucosamine-6-phosphate deaminase activity
AFA_RS04425	COG1132	(ABC) transporter
AFA_RS04445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFA_RS04455	COG0668	transmembrane transport
AFA_RS04500	COG0154	amidase activity
AFA_RS04505	COG2031	fatty acid transporter
AFA_RS04520	COG0483	inositol monophosphate 1-phosphatase activity
AFA_RS04525	COG1253	flavin adenine dinucleotide binding
AFA_RS04530	COG1968	undecaprenyl-diphosphatase activity
AFA_RS04550	COG0215	cysteine-tRNA ligase activity
AFA_RS04560	COG0825	malonyl-CoA metabolic process
AFA_RS04565	COG0037	tRNA processing
AFA_RS04585	COG0330	HflC and HflK could
AFA_RS04600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFA_RS04625	COG4208	sulfate ABC transporter
AFA_RS04630	COG3842	ATPase activity
AFA_RS04640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AFA_RS04670	COG1304	FMN binding
AFA_RS04675	COG0435	Glutathione S-transferase
AFA_RS04680	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFA_RS04695	COG2094	Belongs to the DNA glycosylase MPG family
AFA_RS04700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFA_RS04705	COG2363	Small membrane protein
AFA_RS04710	COG0598	Magnesium transport protein CorA
AFA_RS04715	COG1960	acyl-CoA dehydrogenase activity
AFA_RS04725	COG0747	negative chemotaxis
AFA_RS04735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFA_RS04740	COG4172	Belongs to the ABC transporter superfamily
AFA_RS04750	COG3284	Transcriptional regulator
AFA_RS04755	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS04760	COG1454	alcohol dehydrogenase
AFA_RS04765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFA_RS04790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AFA_RS04820	COG3829	transcription factor binding
AFA_RS04825	COG0477	Major facilitator Superfamily
AFA_RS04835	COG0039	L-malate dehydrogenase activity
AFA_RS04840	COG2188	Transcriptional regulator
AFA_RS04845	COG2009	succinate dehydrogenase
AFA_RS04855	COG1053	succinate dehydrogenase
AFA_RS04860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFA_RS04865	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AFA_RS04870	COG0372	Belongs to the citrate synthase family
AFA_RS04875	COG2186	Transcriptional regulator
AFA_RS04880	COG1620	l-lactate permease
AFA_RS04885	COG0280	phosphate acetyltransferase
AFA_RS04885	COG0281	malic enzyme
AFA_RS04890	COG0567	Dehydrogenase, E1 component
AFA_RS04895	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFA_RS04900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFA_RS04905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AFA_RS04925	COG2183	response to ionizing radiation
AFA_RS04930	COG1199	ATP-dependent helicase activity
AFA_RS04935	COG0659	secondary active sulfate transmembrane transporter activity
AFA_RS04945	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AFA_RS04945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS04950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS04975	COG0564	pseudouridine synthase activity
AFA_RS04985	COG3243	poly(R)-hydroxyalkanoic acid synthase
AFA_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS04995	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AFA_RS05020	COG3772	lysozyme
AFA_RS05080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFA_RS05085	COG1187	pseudouridine synthase activity
AFA_RS05090	COG0779	Required for maturation of 30S ribosomal subunits
AFA_RS05095	COG2251	uridine kinase activity
AFA_RS05095	COG0195	Participates in both transcription termination and antitermination
AFA_RS05105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFA_RS05110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFA_RS05115	COG1217	gtp-binding protein TYPA
AFA_RS05120	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFA_RS05130	COG4160	amino acid transport
AFA_RS05135	COG4215	(ABC) transporter
AFA_RS05145	COG1611	Belongs to the LOG family
AFA_RS05155	COG1283	sodium-dependent phosphate transmembrane transporter activity
AFA_RS05160	COG0501	Belongs to the peptidase M48B family
AFA_RS05175	COG1722	exodeoxyribonuclease VII activity
AFA_RS05180	COG0142	geranyltranstransferase activity
AFA_RS05185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFA_RS05190	COG1469	GTP cyclohydrolase I activity
AFA_RS05195	COG0360	Binds together with S18 to 16S ribosomal RNA
AFA_RS05200	COG2965	DNA replication, synthesis of RNA primer
AFA_RS05205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFA_RS05210	COG0359	binds to the 23S rRNA
AFA_RS05215	COG0305	Participates in initiation and elongation during chromosome replication
AFA_RS05225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFA_RS05230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFA_RS05235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFA_RS05245	COG0436	Aminotransferase
AFA_RS05265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFA_RS05270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AFA_RS05275	COG1562	ergosterol biosynthetic process
AFA_RS05280	COG1562	ergosterol biosynthetic process
AFA_RS05285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFA_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS05315	COG3842	ATPase activity
AFA_RS05320	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFA_RS05325	COG1177	transmembrane transport
AFA_RS05330	COG1393	Belongs to the ArsC family
AFA_RS05335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFA_RS05340	COG0704	Plays a role in the regulation of phosphate uptake
AFA_RS05345	COG2203	Gaf domain
AFA_RS05345	COG3706	GGDEF domain
AFA_RS05345	COG4251	negative regulation of phosphorylation
AFA_RS05345	COG5001	Diguanylate cyclase
AFA_RS05350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AFA_RS05355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFA_RS05355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFA_RS05360	COG1643	Atp-dependent helicase
AFA_RS05370	COG0438	transferase activity, transferring glycosyl groups
AFA_RS05375	COG0726	polysaccharide deacetylase
AFA_RS05390	COG0297	glycogen (starch) synthase activity
AFA_RS05415	COG1132	(ABC) transporter
AFA_RS05465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS05485	COG2186	Transcriptional regulator
AFA_RS05490	COG0277	FAD linked oxidase domain protein
AFA_RS05495	COG0277	FAD linked oxidase domain protein
AFA_RS05500	COG0247	lactate metabolic process
AFA_RS05530	COG2159	amidohydrolase
AFA_RS05545	COG0583	DNA-binding transcription factor activity
AFA_RS05550	COG0477	Major facilitator Superfamily
AFA_RS05605	COG0628	permease
AFA_RS05610	COG1283	sodium-dependent phosphate transmembrane transporter activity
AFA_RS05625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AFA_RS05635	COG0697	spore germination
AFA_RS05655	COG3094	Invasion gene expression up-regulator, SirB
AFA_RS05665	COG0640	Transcriptional regulator
AFA_RS05690	COG0659	secondary active sulfate transmembrane transporter activity
AFA_RS05695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFA_RS05705	COG2314	TM2 domain
AFA_RS05710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFA_RS05715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFA_RS05720	COG0791	NLP P60 protein
AFA_RS05740	COG1360	Flagellar Motor Protein
AFA_RS05750	COG0835	chemotaxis
AFA_RS05755	COG0840	transmembrane signaling receptor activity
AFA_RS05760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFA_RS05770	COG0745	RESPONSE REGULATOR receiver
AFA_RS05775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AFA_RS05780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFA_RS05785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFA_RS05795	COG3550	peptidyl-serine autophosphorylation
AFA_RS05820	COG1815	bacterial-type flagellum-dependent cell motility
AFA_RS05825	COG1558	bacterial-type flagellum-dependent cell motility
AFA_RS05830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFA_RS05870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFA_RS05885	COG0840	transmembrane signaling receptor activity
AFA_RS05905	COG1987	bacterial-type flagellum assembly
AFA_RS05920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFA_RS05945	COG1157	protein secretion by the type III secretion system
AFA_RS05960	COG1766	The M ring may be actively involved in energy transduction
AFA_RS05965	COG1677	Flagellar hook-basal body complex protein FliE
AFA_RS05970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFA_RS05995	COG1334	flagellar protein FlaG
AFA_RS06000	COG1191	sigma factor activity
AFA_RS06055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFA_RS06075	COG2733	membrane
AFA_RS06080	COG0840	transmembrane signaling receptor activity
AFA_RS06085	COG0840	transmembrane signaling receptor activity
AFA_RS06110	COG2610	gluconate transmembrane transporter activity
AFA_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS06130	COG2824	Alkylphosphonate utilization operon protein PhnA
AFA_RS06145	COG4771	TonB-dependent receptor
AFA_RS06150	COG1858	cytochrome C peroxidase
AFA_RS06155	COG1454	alcohol dehydrogenase
AFA_RS06175	COG0668	transmembrane transport
AFA_RS06180	COG1113	amino acid transport
AFA_RS06185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFA_RS06225	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFA_RS06250	COG1278	Cold shock
AFA_RS06275	COG0515	serine threonine protein kinase
AFA_RS06275	COG2815	serine threonine protein kinase
AFA_RS06370	COG0642	Histidine kinase
AFA_RS06380	COG3278	Belongs to the heme-copper respiratory oxidase family
AFA_RS06390	COG2863	cytochrome
AFA_RS06395	COG3258	Cytochrome c
AFA_RS06400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFA_RS06405	COG4774	siderophore transport
AFA_RS06450	COG1289	transmembrane transporter activity
AFA_RS06455	COG2252	PERMEase
AFA_RS06475	COG1999	signal sequence binding
AFA_RS06485	COG0069	glutamate synthase activity
AFA_RS06495	COG1846	Transcriptional regulator
AFA_RS06500	COG1058	Belongs to the CinA family
AFA_RS06500	COG1546	Belongs to the CinA family
AFA_RS06505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFA_RS06545	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS06555	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS06570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFA_RS06580	COG3264	Mechanosensitive ion channel
AFA_RS06580	COG1511	domain protein
AFA_RS06585	COG3264	Mechanosensitive ion channel
AFA_RS06585	COG1511	domain protein
AFA_RS06590	COG0477	Major facilitator Superfamily
AFA_RS06605	COG1396	sequence-specific DNA binding
AFA_RS06610	COG3437	response regulator, receiver
AFA_RS06615	COG2205	protein histidine kinase activity
AFA_RS06615	COG2198	Histidine kinase
AFA_RS06615	COG0784	Response regulator, receiver
AFA_RS06620	COG2239	Acts as a magnesium transporter
AFA_RS06630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFA_RS06635	COG1490	D-aminoacyl-tRNA deacylase activity
AFA_RS06650	COG0456	acetyltransferase
AFA_RS06655	COG3012	SEC-C Motif Domain Protein
AFA_RS06660	COG0501	Belongs to the peptidase M48B family
AFA_RS06860	COG5410	chromosome segregation
AFA_RS06980	COG3772	lysozyme
AFA_RS07000	COG2135	peptidase activity
AFA_RS07150	COG3772	lysozyme
AFA_RS07205	COG3706	GGDEF domain
AFA_RS07220	COG1522	sequence-specific DNA binding
AFA_RS07225	COG0626	cystathionine gamma-synthase activity
AFA_RS07235	COG0494	nUDIX hydrolase
AFA_RS07240	COG2832	Protein of unknown function (DUF454)
AFA_RS07250	COG0137	argininosuccinate synthase activity
AFA_RS07255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFA_RS07280	COG1609	Transcriptional regulator
AFA_RS07285	COG0519	Catalyzes the synthesis of GMP from XMP
AFA_RS07285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFA_RS07295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFA_RS07305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AFA_RS07310	COG2205	protein histidine kinase activity
AFA_RS07315	COG0745	RESPONSE REGULATOR receiver
AFA_RS07320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFA_RS07330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFA_RS07335	COG0268	Binds directly to 16S ribosomal RNA
AFA_RS07340	COG0728	peptidoglycan biosynthetic process
AFA_RS07350	COG0563	adenylate kinase activity
AFA_RS07355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFA_RS07360	COG2835	tetraacyldisaccharide 4'-kinase activity
AFA_RS07365	COG1663	tetraacyldisaccharide 4'-kinase activity
AFA_RS07370	COG0848	biopolymer transport protein
AFA_RS07375	COG0811	peptide transport
AFA_RS07380	COG1570	exodeoxyribonuclease VII activity
AFA_RS07385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFA_RS07395	COG0183	Belongs to the thiolase family
AFA_RS07405	COG1278	Cold shock
AFA_RS07410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFA_RS07415	COG0542	response to heat
AFA_RS07420	COG2995	paraquat-inducible protein a
AFA_RS07425	COG3008	intermembrane lipid transfer
AFA_RS07425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFA_RS07445	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS07470	COG0300	oxidoreductase activity
AFA_RS07490	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AFA_RS07495	COG0756	dUTP diphosphatase activity
AFA_RS07505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFA_RS07510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFA_RS07515	COG0196	riboflavin kinase activity
AFA_RS07520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFA_RS07525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFA_RS07525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFA_RS07535	COG0210	DNA helicase
AFA_RS07560	COG0488	(ABC) transporter
AFA_RS07565	COG2890	protein-(glutamine-N5) methyltransferase activity
AFA_RS07570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFA_RS07575	COG2171	N-acyltransferase activity
AFA_RS07585	COG2207	Transcriptional regulator
AFA_RS07595	COG0471	metal ion transport
AFA_RS07595	COG3273	potassium ion transport
AFA_RS07640	COG0789	Transcriptional regulator
AFA_RS07660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFA_RS07665	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFA_RS07670	COG0740	serine-type endopeptidase activity
AFA_RS07680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFA_RS07690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFA_RS07700	COG0556	nucleotide-excision repair
AFA_RS07705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFA_RS07715	COG1104	cysteine desulfurase activity
AFA_RS07725	COG0316	Belongs to the HesB IscA family
AFA_RS07740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFA_RS07745	COG4221	oxidoreductase activity
AFA_RS07755	COG0840	transmembrane signaling receptor activity
AFA_RS07760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFA_RS07765	COG0697	spore germination
AFA_RS07770	COG0385	Bile acid
AFA_RS07780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFA_RS07795	COG1136	(ABC) transporter
AFA_RS07800	COG0084	hydrolase, TatD family'
AFA_RS07815	COG0613	PHP domain protein
AFA_RS07825	COG0047	phosphoribosylformylglycinamidine synthase activity
AFA_RS07825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFA_RS07840	COG0519	Catalyzes the synthesis of GMP from XMP
AFA_RS07840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFA_RS07865	COG4691	Plasmid stability protein
AFA_RS07900	COG0798	PFAM Bile acid sodium symporter
AFA_RS07940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFA_RS07960	COG0583	DNA-binding transcription factor activity
AFA_RS07980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFA_RS07990	COG1960	acyl-CoA dehydrogenase activity
AFA_RS08000	COG2378	regulation of single-species biofilm formation
AFA_RS08005	COG0523	cobalamin synthesis protein
AFA_RS08010	COG1469	GTP cyclohydrolase I activity
AFA_RS08015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFA_RS08025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFA_RS08030	COG0735	belongs to the Fur family
AFA_RS08035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFA_RS08045	COG0494	nUDIX hydrolase
AFA_RS08050	COG1942	4-Oxalocrotonate Tautomerase
AFA_RS08065	COG2070	2-Nitropropane dioxygenase
AFA_RS08095	COG0625	glutathione transferase activity
AFA_RS08100	COG0583	DNA-binding transcription factor activity
AFA_RS08120	COG0625	glutathione transferase activity
AFA_RS08125	COG0740	serine-type endopeptidase activity
AFA_RS08175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFA_RS08185	COG1960	acyl-CoA dehydrogenase activity
AFA_RS08205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFA_RS08210	COG0640	Transcriptional regulator
AFA_RS08230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFA_RS08245	COG3485	protocatechuate 3,4-dioxygenase
AFA_RS08255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFA_RS08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFA_RS08270	COG3135	benzoate transporter
AFA_RS08275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFA_RS08280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFA_RS08295	COG4555	ABC transporter
AFA_RS08305	COG2197	response regulator
AFA_RS08310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFA_RS08340	COG1846	Transcriptional regulator
AFA_RS08345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFA_RS08350	COG2271	Major facilitator Superfamily
AFA_RS08360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFA_RS08370	COG0697	spore germination
AFA_RS08400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFA_RS08405	COG0667	Aldo Keto reductase
AFA_RS08420	COG1272	protein, Hemolysin III
AFA_RS08425	COG3422	double-strand break repair
AFA_RS08435	COG0477	Major facilitator Superfamily
AFA_RS08440	COG0154	amidase activity
AFA_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS08470	COG0765	amino acid transport
AFA_RS08475	COG0765	amino acid transport
AFA_RS08480	COG1126	abc transporter atp-binding protein
AFA_RS08535	COG2871	sodium ion transport
AFA_RS08575	COG2814	Major facilitator Superfamily
AFA_RS08585	COG1280	lysine exporter protein (LysE YggA)
AFA_RS08605	COG0402	S-adenosylhomocysteine deaminase activity
AFA_RS08625	COG0330	HflC and HflK could
AFA_RS08630	COG1585	Membrane protein implicated in regulation of membrane protease activity
AFA_RS08635	COG2226	methyltransferase
AFA_RS08645	COG3042	response to heat
AFA_RS08655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFA_RS08665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFA_RS08670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFA_RS08685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFA_RS08690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFA_RS08720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFA_RS08725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFA_RS08730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFA_RS08735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFA_RS08735	COG0072	phenylalanine-tRNA ligase activity
AFA_RS08750	COG2833	Protein of unknown function (DUF455)
AFA_RS08760	COG5265	(ABC) transporter
AFA_RS08765	COG1959	2 iron, 2 sulfur cluster binding
AFA_RS08770	COG0719	Fe-S assembly protein
AFA_RS08775	COG0396	ATPase activity
AFA_RS08780	COG0719	Fe-S assembly protein
AFA_RS08790	COG0822	iron-sulfur transferase activity
AFA_RS08795	COG2151	metal-sulfur cluster biosynthetic enzyme
AFA_RS08830	COG1215	transferase activity, transferring glycosyl groups
AFA_RS08835	COG1649	PFAM Uncharacterised BCR, COG1649
AFA_RS08835	COG0726	polysaccharide deacetylase
AFA_RS08840	COG0457	Tetratricopeptide repeat
AFA_RS08855	COG1278	Cold shock
AFA_RS08905	COG0747	negative chemotaxis
AFA_RS08910	COG0601	transmembrane transport
AFA_RS08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFA_RS08920	COG4172	Belongs to the ABC transporter superfamily
AFA_RS08930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFA_RS08980	COG0604	alcohol dehydrogenase
AFA_RS08985	COG2207	Transcriptional regulator
AFA_RS08995	COG3949	Membrane
AFA_RS09005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFA_RS09020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFA_RS09025	COG0569	domain protein
AFA_RS09030	COG1902	pentaerythritol trinitrate reductase activity
AFA_RS09040	COG1610	YqeY-like protein
AFA_RS09045	COG0587	DNA-directed DNA polymerase activity
AFA_RS09075	COG2988	succinylglutamate desuccinylase activity
AFA_RS09080	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS09085	COG0583	DNA-binding transcription factor activity
AFA_RS09090	COG1686	Belongs to the peptidase S11 family
AFA_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS09120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFA_RS09125	COG4221	oxidoreductase activity
AFA_RS09130	COG0307	riboflavin synthase, alpha
AFA_RS09145	COG1301	dicarboxylic acid transport
AFA_RS09150	COG4191	Histidine kinase
AFA_RS09160	COG0583	DNA-binding transcription factor activity
AFA_RS09165	COG1053	succinate dehydrogenase
AFA_RS09215	COG2233	PERMEase
AFA_RS09220	COG0071	Belongs to the small heat shock protein (HSP20) family
AFA_RS09260	COG1846	Transcriptional regulator
AFA_RS09265	COG2816	NAD+ diphosphatase activity
AFA_RS09270	COG1561	YicC-like family, N-terminal region
AFA_RS09285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFA_RS09290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFA_RS09295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFA_RS09300	COG0174	glutamine synthetase
AFA_RS09305	COG2153	protein acetylation
AFA_RS09325	COG3842	ATPase activity
AFA_RS09330	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFA_RS09335	COG1840	ABC-type Fe3 transport system, periplasmic component
AFA_RS09350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFA_RS09360	COG0783	Belongs to the Dps family
AFA_RS09370	COG3842	ATPase activity
AFA_RS09375	COG0395	ABC-type sugar transport system, permease component
AFA_RS09380	COG1175	transmembrane transport
AFA_RS09385	COG1653	transport
AFA_RS09400	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS09425	COG0625	glutathione transferase activity
AFA_RS09435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFA_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS09450	COG0114	fumarate hydratase activity
AFA_RS09455	COG2133	pyrroloquinoline quinone binding
AFA_RS09460	COG2226	methyltransferase
AFA_RS09465	COG0589	response to stress
AFA_RS09475	COG2807	transmembrane transport
AFA_RS09485	COG0583	DNA-binding transcription factor activity
AFA_RS09505	COG4974	Belongs to the 'phage' integrase family
AFA_RS09515	COG2132	Multicopper oxidase
AFA_RS09520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AFA_RS09665	COG0515	serine threonine protein kinase
AFA_RS09665	COG2815	serine threonine protein kinase
AFA_RS09700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFA_RS09740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFA_RS09760	COG2003	Belongs to the UPF0758 family
AFA_RS09805	COG1160	GTP binding
AFA_RS09820	COG1196	nuclear chromosome segregation
AFA_RS09870	COG2894	cell division
AFA_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS09980	COG1683	Conserved Protein
AFA_RS10015	COG3038	cytochrome b561
AFA_RS10025	COG2353	YceI-like domain
AFA_RS10030	COG1393	Belongs to the ArsC family
AFA_RS10035	COG0625	glutathione transferase activity
AFA_RS10055	COG0084	hydrolase, TatD family'
AFA_RS10060	COG0470	DNA polymerase III
AFA_RS10070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFA_RS10075	COG0354	folic acid binding
AFA_RS10090	COG1960	acyl-CoA dehydrogenase activity
AFA_RS10095	COG2914	Belongs to the UPF0125 (RnfH) family
AFA_RS10100	COG2867	negative regulation of translational initiation
AFA_RS10105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFA_RS10110	COG1252	NADH dehydrogenase
AFA_RS10135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFA_RS10140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFA_RS10145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFA_RS10155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFA_RS10160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFA_RS10170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFA_RS10180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFA_RS10185	COG0575	Belongs to the CDS family
AFA_RS10190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFA_RS10195	COG0233	cytoplasmic translational termination
AFA_RS10200	COG0528	UMP kinase activity
AFA_RS10205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFA_RS10210	COG0052	Belongs to the universal ribosomal protein uS2 family
AFA_RS10215	COG0024	Methionine aminopeptidase
AFA_RS10220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFA_RS10245	COG1286	toxin biosynthetic process
AFA_RS10255	COG0285	dihydrofolate synthase activity
AFA_RS10260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFA_RS10265	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFA_RS10270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFA_RS10285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFA_RS10295	COG1999	signal sequence binding
AFA_RS10300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFA_RS10310	COG0640	Transcriptional regulator
AFA_RS10325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS10330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AFA_RS10335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS10340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFA_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS10370	COG0183	Belongs to the thiolase family
AFA_RS10390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFA_RS10400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFA_RS10405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS10410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AFA_RS10430	COG0183	Belongs to the thiolase family
AFA_RS10435	COG0183	Belongs to the thiolase family
AFA_RS10445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFA_RS10475	COG0194	GDP metabolic process
AFA_RS10480	COG1758	RNA polymerase activity
AFA_RS10485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFA_RS10495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFA_RS10500	COG0739	heme binding
AFA_RS10505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFA_RS10510	COG0584	glycerophosphoryl diester phosphodiesterase
AFA_RS10515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AFA_RS10520	COG1187	pseudouridine synthase activity
AFA_RS10525	COG3161	chorismate lyase activity
AFA_RS10530	COG2814	Major facilitator Superfamily
AFA_RS10535	COG0656	L-ascorbic acid biosynthetic process
AFA_RS10545	COG0668	transmembrane transport
AFA_RS10550	COG0165	Argininosuccinate lyase
AFA_RS10565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS10575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFA_RS10585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFA_RS10590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFA_RS10595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFA_RS10600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFA_RS10605	COG2252	PERMEase
AFA_RS10610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFA_RS10630	COG0488	(ABC) transporter
AFA_RS10635	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFA_RS10645	COG1131	(ABC) transporter
AFA_RS10650	COG0842	Transport permease protein
AFA_RS10660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AFA_RS10660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS10665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AFA_RS10670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AFA_RS10675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS10685	COG2022	thiamine diphosphate biosynthetic process
AFA_RS10705	COG1414	Transcriptional regulator
AFA_RS10715	COG0730	response to heat
AFA_RS10725	COG1666	GTP binding
AFA_RS10730	COG0318	PFAM AMP-dependent synthetase and ligase
AFA_RS10735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFA_RS10740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFA_RS10740	COG0519	Catalyzes the synthesis of GMP from XMP
AFA_RS10745	COG2207	Transcriptional regulator
AFA_RS10760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFA_RS10765	COG0135	phosphoribosylanthranilate isomerase activity
AFA_RS10770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS10780	COG0101	tRNA pseudouridine synthase activity
AFA_RS10790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFA_RS10795	COG0473	3-isopropylmalate dehydrogenase activity
AFA_RS10810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFA_RS10820	COG4566	intracellular signal transduction
AFA_RS10835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFA_RS10840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFA_RS10850	COG1295	ribonuclease BN
AFA_RS10860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFA_RS10895	COG4964	Belongs to the GSP D family
AFA_RS10930	COG3712	iron ion homeostasis
AFA_RS10935	COG1595	DNA-templated transcription, initiation
AFA_RS10945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFA_RS10955	COG2959	enzyme of heme biosynthesis
AFA_RS10965	COG0181	hydroxymethylbilane synthase activity
AFA_RS10970	COG0861	Integral membrane protein TerC family
AFA_RS10975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFA_RS10980	COG0045	succinate-CoA ligase (ADP-forming) activity
AFA_RS10990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFA_RS10995	COG0583	DNA-binding transcription factor activity
AFA_RS11000	COG2137	regulation of response to DNA damage stimulus
AFA_RS11005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFA_RS11020	COG0477	Major facilitator Superfamily
AFA_RS11035	COG0318	PFAM AMP-dependent synthetase and ligase
AFA_RS11040	COG1024	Enoyl-CoA hydratase
AFA_RS11045	COG3162	membrane
AFA_RS11060	COG0540	Belongs to the ATCase OTCase family
AFA_RS11075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFA_RS11090	COG2070	2-Nitropropane dioxygenase
AFA_RS11095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFA_RS11100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFA_RS11100	COG2111	Na H antiporter
AFA_RS11105	COG1006	Multisubunit Na H antiporter MnhC subunit
AFA_RS11110	COG0651	ATP synthesis coupled electron transport
AFA_RS11120	COG2212	antiporter activity
AFA_RS11135	COG3158	transport of potassium into the cell
AFA_RS11140	COG0642	Histidine kinase
AFA_RS11165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFA_RS11170	COG4208	sulfate ABC transporter
AFA_RS11175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFA_RS11180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AFA_RS11195	COG1278	Cold shock
AFA_RS11220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFA_RS11220	COG1648	precorrin-2 dehydrogenase activity
AFA_RS11225	COG2010	Cytochrome c
AFA_RS11235	COG1522	sequence-specific DNA binding
AFA_RS11250	COG0535	radical SAM domain protein
AFA_RS11260	COG1648	precorrin-2 dehydrogenase activity
AFA_RS11260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFA_RS11270	COG2010	Cytochrome c
AFA_RS11275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS11285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFA_RS11290	COG0557	exoribonuclease II activity
AFA_RS11320	COG2375	cellular response to nickel ion
AFA_RS11350	COG0583	DNA-binding transcription factor activity
AFA_RS11355	COG3842	ATPase activity
AFA_RS11365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFA_RS11370	COG1840	ABC-type Fe3 transport system, periplasmic component
AFA_RS11395	COG3530	Putative quorum-sensing-regulated virulence factor
AFA_RS11400	COG0625	glutathione transferase activity
AFA_RS11410	COG1741	Belongs to the pirin family
AFA_RS11420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFA_RS11425	COG2814	Major facilitator Superfamily
AFA_RS11430	COG2807	transmembrane transport
AFA_RS11435	COG2207	Transcriptional regulator
AFA_RS11440	COG3135	benzoate transporter
AFA_RS11465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFA_RS11475	COG0402	S-adenosylhomocysteine deaminase activity
AFA_RS11485	COG0745	RESPONSE REGULATOR receiver
AFA_RS11490	COG2205	protein histidine kinase activity
AFA_RS11505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFA_RS11510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFA_RS11515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFA_RS11520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFA_RS11525	COG0330	HflC and HflK could
AFA_RS11530	COG0330	HflC and HflK could
AFA_RS11535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFA_RS11540	COG1923	regulation of RNA biosynthetic process
AFA_RS11550	COG1160	GTP binding
AFA_RS11555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFA_RS11560	COG2976	Protein conserved in bacteria
AFA_RS11580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFA_RS11585	COG0105	UTP biosynthetic process
AFA_RS11600	COG0336	Belongs to the RNA methyltransferase TrmD family
AFA_RS11610	COG0228	four-way junction DNA binding
AFA_RS11615	COG0425	Belongs to the sulfur carrier protein TusA family
AFA_RS11620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFA_RS11635	COG2351	hydroxyisourate hydrolase activity
AFA_RS11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS11690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFA_RS11695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFA_RS11710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFA_RS11715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFA_RS11720	COG0542	response to heat
AFA_RS11725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFA_RS11740	COG0348	domain, Protein
AFA_RS11760	COG3278	Belongs to the heme-copper respiratory oxidase family
AFA_RS11770	COG2217	Heavy metal translocating P-type atpase
AFA_RS11780	COG2224	Isocitrate lyase
AFA_RS11785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFA_RS11785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFA_RS11805	COG1472	Belongs to the glycosyl hydrolase 3 family
AFA_RS11810	COG0736	holo-[acyl-carrier-protein] synthase activity
AFA_RS11820	COG2050	protein possibly involved in aromatic compounds catabolism
AFA_RS11825	COG1024	Enoyl-CoA hydratase
AFA_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS11835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFA_RS11840	COG2151	metal-sulfur cluster biosynthetic enzyme
AFA_RS11845	COG3396	Phenylacetate-CoA oxygenase
AFA_RS11850	COG3460	Phenylacetate-CoA oxygenase
AFA_RS11855	COG3396	Phenylacetate-CoA oxygenase
AFA_RS11860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFA_RS11865	COG0501	Belongs to the peptidase M48B family
AFA_RS11870	COG1162	GTPase activity
AFA_RS11880	COG0335	large ribosomal subunit rRNA binding
AFA_RS11895	COG0450	alkyl hydroperoxide reductase
AFA_RS11900	COG1960	acyl-CoA dehydrogenase activity
AFA_RS11920	COG2951	lytic endotransglycosylase activity
AFA_RS11935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFA_RS11940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFA_RS11945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AFA_RS11965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFA_RS11970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFA_RS11975	COG0287	Prephenate dehydrogenase
AFA_RS11985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFA_RS12000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFA_RS12020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFA_RS12030	COG4771	TonB-dependent receptor
AFA_RS12045	COG0753	catalase activity
AFA_RS12055	COG4335	DNA alkylation repair
AFA_RS12060	COG1846	Transcriptional regulator
AFA_RS12065	COG0436	Aminotransferase
AFA_RS12070	COG1309	transcriptional regulator
AFA_RS12105	COG0625	glutathione transferase activity
AFA_RS12185	COG2948	multi-organism process
AFA_RS12230	COG0433	COG0433 Predicted ATPase
AFA_RS12285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFA_RS12310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFA_RS12325	COG0577	efflux transmembrane transporter activity
AFA_RS12325	COG1136	(ABC) transporter
AFA_RS12335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS12340	COG1309	transcriptional regulator
AFA_RS12360	COG3596	GTP binding
AFA_RS12375	COG4974	Belongs to the 'phage' integrase family
AFA_RS12385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AFA_RS12390	COG1280	lysine exporter protein (LysE YggA)
AFA_RS12415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFA_RS12425	COG5002	protein histidine kinase activity
AFA_RS12430	COG2046	Belongs to the sulfate adenylyltransferase family
AFA_RS12435	COG2814	Major facilitator Superfamily
AFA_RS12445	COG0583	DNA-binding transcription factor activity
AFA_RS12450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFA_RS12465	COG0840	transmembrane signaling receptor activity
AFA_RS12470	COG2119	membrane
AFA_RS12485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFA_RS12490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFA_RS12505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFA_RS12510	COG2321	neutral zinc metallopeptidase
AFA_RS12520	COG0347	Belongs to the P(II) protein family
AFA_RS12525	COG0004	ammonium transporteR
AFA_RS12530	COG3909	cytochrome
AFA_RS12540	COG0625	glutathione transferase activity
AFA_RS12550	COG0657	acetylesterase activity
AFA_RS12555	COG0730	response to heat
AFA_RS12560	COG0482	sulfurtransferase activity
AFA_RS12565	COG0277	FAD linked oxidase domain protein
AFA_RS12570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AFA_RS12575	COG2879	small protein
AFA_RS12580	COG1966	Carbon starvation protein
AFA_RS12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS12590	COG0765	amino acid transport
AFA_RS12595	COG0765	amino acid transport
AFA_RS12600	COG1126	abc transporter atp-binding protein
AFA_RS12615	COG5285	phytanoyl-CoA dioxygenase
AFA_RS12620	COG0662	Cupin 2, conserved barrel domain protein
AFA_RS12635	COG1846	Transcriptional regulator
AFA_RS12650	COG0312	modulator of DNA gyrase
AFA_RS12665	COG0308	aminopeptidase N
AFA_RS12670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFA_RS12685	COG0473	3-isopropylmalate dehydrogenase activity
AFA_RS12695	COG0433	COG0433 Predicted ATPase
AFA_RS12700	COG0217	transcriptional regulatory protein
AFA_RS12705	COG0151	Belongs to the GarS family
AFA_RS12715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFA_RS12720	COG0799	negative regulation of ribosome biogenesis
AFA_RS12725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFA_RS12730	COG0424	maF-like protein
AFA_RS12750	COG0023	Translation Initiation Factor
AFA_RS12760	COG2084	Dehydrogenase
AFA_RS12765	COG0625	glutathione transferase activity
AFA_RS12770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFA_RS12775	COG1047	Peptidyl-prolyl cis-trans
AFA_RS12780	COG2003	Belongs to the UPF0758 family
AFA_RS12795	COG0534	Mate efflux family protein
AFA_RS12800	COG4175	Glycine betaine
AFA_RS12805	COG4176	ABC-type proline glycine betaine transport system permease component
AFA_RS12815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFA_RS12820	COG2814	Major facilitator Superfamily
AFA_RS12825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFA_RS12830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFA_RS12835	COG0495	leucyl-tRNA aminoacylation
AFA_RS12845	COG1466	dna polymerase III delta subunit
AFA_RS12850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFA_RS12855	COG1981	membrane
AFA_RS12870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFA_RS12880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AFA_RS12885	COG0148	phosphopyruvate hydratase activity
AFA_RS12895	COG2814	Major facilitator Superfamily
AFA_RS12910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFA_RS12915	COG0504	CTP synthase activity
AFA_RS12950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFA_RS12960	COG0791	NLP P60 protein
AFA_RS12970	COG0583	DNA-binding transcription factor activity
AFA_RS12980	COG0583	DNA-binding transcription factor activity
AFA_RS12985	COG4774	siderophore transport
AFA_RS12995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFA_RS13005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFA_RS13010	COG1309	transcriptional regulator
AFA_RS13020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFA_RS13035	COG1045	serine acetyltransferase
AFA_RS13050	COG1381	Involved in DNA repair and RecF pathway recombination
AFA_RS13055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFA_RS13060	COG0571	ribonuclease III activity
AFA_RS13075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFA_RS13100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFA_RS13105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFA_RS13110	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS13115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFA_RS13120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFA_RS13130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFA_RS13135	COG1399	metal-binding, possibly nucleic acid-binding protein
AFA_RS13140	COG0424	maF-like protein
AFA_RS13150	COG3023	N-Acetylmuramoyl-L-alanine amidase
AFA_RS13155	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AFA_RS13160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFA_RS13165	COG0546	phosphoglycolate phosphatase activity
AFA_RS13170	COG0564	pseudouridine synthase activity
AFA_RS13175	COG1530	ribonuclease E activity
AFA_RS13180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFA_RS13185	COG0159	tryptophan synthase activity
AFA_RS13190	COG0133	tryptophan synthase activity
AFA_RS13195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFA_RS13205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFA_RS13210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFA_RS13220	COG2878	Part of a membrane complex involved in electron transport
AFA_RS13225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFA_RS13235	COG3047	cAMP biosynthetic process
AFA_RS13260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFA_RS13265	COG2917	probably involved in intracellular septation
AFA_RS13275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFA_RS13280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFA_RS13290	COG1196	nuclear chromosome segregation
AFA_RS13300	COG1573	uracil-dna glycosylase
AFA_RS13305	COG1214	PFAM Peptidase M22, glycoprotease
AFA_RS13320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFA_RS13325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFA_RS13330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFA_RS13340	COG0560	Phosphoserine phosphatase
AFA_RS13355	COG1007	ATP synthesis coupled electron transport
AFA_RS13370	COG0713	ATP synthesis coupled electron transport
AFA_RS13380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFA_RS13385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFA_RS13390	COG1034	ATP synthesis coupled electron transport
AFA_RS13405	COG0649	NAD binding
AFA_RS13410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFA_RS13415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFA_RS13420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFA_RS13425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AFA_RS13440	COG0149	triose-phosphate isomerase activity
AFA_RS13445	COG0604	alcohol dehydrogenase
AFA_RS13465	COG1185	polyribonucleotide nucleotidyltransferase activity
AFA_RS13470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFA_RS13475	COG1183	phosphatidylcholine synthase activity
AFA_RS13480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFA_RS13485	COG0440	acetolactate synthase activity
AFA_RS13490	COG0028	Belongs to the TPP enzyme family
AFA_RS13495	COG1289	transmembrane transporter activity
AFA_RS13500	COG3022	response to hydroperoxide
AFA_RS13505	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS13530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFA_RS13535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFA_RS13540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFA_RS13545	COG1674	ftsk spoiiie
AFA_RS13550	COG0492	ferredoxin-NADP+ reductase activity
AFA_RS13570	COG0477	Major facilitator Superfamily
AFA_RS13590	COG2272	Belongs to the type-B carboxylesterase lipase family
AFA_RS13595	COG1960	acyl-CoA dehydrogenase activity
AFA_RS13620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFA_RS13640	COG2204	response regulator
AFA_RS13680	COG4964	Belongs to the GSP D family
AFA_RS13740	COG0612	Peptidase, M16
AFA_RS13745	COG0484	heat shock protein binding
AFA_RS13750	COG0443	Heat shock 70 kDa protein
AFA_RS13755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFA_RS13760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFA_RS13765	COG1420	regulation of RNA biosynthetic process
AFA_RS13775	COG0497	DNA recombination
AFA_RS13780	COG0735	belongs to the Fur family
AFA_RS13785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFA_RS13800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFA_RS13820	COG5001	Diguanylate cyclase
AFA_RS13820	COG3300	MHYT domain
AFA_RS13835	COG2814	Major facilitator Superfamily
AFA_RS13850	COG2819	hydrolase of the alpha beta superfamily
AFA_RS13860	COG0506	proline dehydrogenase activity
AFA_RS13860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFA_RS13860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFA_RS13875	COG2423	ornithine cyclodeaminase activity
AFA_RS13880	COG0477	Major facilitator Superfamily
AFA_RS13885	COG0513	Belongs to the DEAD box helicase family
AFA_RS13890	COG3657	addiction module killer protein
AFA_RS13895	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFA_RS13900	COG0583	DNA-binding transcription factor activity
AFA_RS13905	COG4638	Rieske (2fe-2S)
AFA_RS13925	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFA_RS13945	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AFA_RS13950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFA_RS13955	COG2814	Major facilitator Superfamily
AFA_RS13970	COG0154	amidase activity
AFA_RS13975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS13980	COG2814	Major facilitator Superfamily
AFA_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS14020	COG0842	Transport permease protein
AFA_RS14025	COG0842	Transport permease protein
AFA_RS14025	COG1129	ABC transporter
AFA_RS14030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS14035	COG1538	Outer membrane efflux protein
AFA_RS14040	COG3243	poly(R)-hydroxyalkanoic acid synthase
AFA_RS14045	COG1309	transcriptional regulator
AFA_RS14050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AFA_RS14055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFA_RS14060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFA_RS14075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFA_RS14090	COG0505	Belongs to the CarA family
AFA_RS14095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFA_RS14105	COG0789	Transcriptional regulator
AFA_RS14115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFA_RS14165	COG3278	Belongs to the heme-copper respiratory oxidase family
AFA_RS14170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS14190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFA_RS14220	COG2885	chlorophyll binding
AFA_RS14220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AFA_RS14230	COG2199	diguanylate cyclase activity
AFA_RS14230	COG2202	Pas domain
AFA_RS14230	COG2200	EAL domain
AFA_RS14235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFA_RS14300	COG0517	IMP dehydrogenase activity
AFA_RS14300	COG0516	GMP reductase activity
AFA_RS14315	COG1027	Aspartate ammonia-lyase
AFA_RS14320	COG1846	Transcriptional regulator
AFA_RS14330	COG0494	nUDIX hydrolase
AFA_RS14335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFA_RS14340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFA_RS14355	COG1414	Transcriptional regulator
AFA_RS14375	COG0513	Belongs to the DEAD box helicase family
AFA_RS14395	COG0429	hydrolase of the alpha beta-hydrolase fold
AFA_RS14420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFA_RS14430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AFA_RS14440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFA_RS14445	COG0632	four-way junction helicase activity
AFA_RS14455	COG2255	four-way junction helicase activity
AFA_RS14465	COG0418	dihydroorotase activity
AFA_RS14475	COG0415	Belongs to the DNA photolyase family
AFA_RS14535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFA_RS14570	COG1177	transmembrane transport
AFA_RS14575	COG3842	ATPase activity
AFA_RS14580	COG1840	ABC-type Fe3 transport system, periplasmic component
AFA_RS14585	COG2084	Dehydrogenase
AFA_RS14600	COG0494	nUDIX hydrolase
AFA_RS14605	COG0442	prolyl-tRNA aminoacylation
AFA_RS14610	COG0824	Thioesterase
AFA_RS14615	COG0811	peptide transport
AFA_RS14630	COG0823	Involved in the tonB-independent uptake of proteins
AFA_RS14670	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFA_RS14675	COG4603	Belongs to the binding-protein-dependent transport system permease family
AFA_RS14680	COG3845	ABC transporter
AFA_RS14700	COG0427	acetyl-CoA hydrolase
AFA_RS14705	COG0583	DNA-binding transcription factor activity
AFA_RS14715	COG3634	alkyl hydroperoxide reductase activity
AFA_RS14730	COG0697	spore germination
AFA_RS14735	COG0175	sulfate reduction
AFA_RS14745	COG2895	sulfate adenylyltransferase (ATP) activity
AFA_RS14755	COG1012	belongs to the aldehyde dehydrogenase family
AFA_RS14760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFA_RS14765	COG5383	Protein conserved in bacteria
AFA_RS14775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFA_RS14790	COG0583	DNA-binding transcription factor activity
AFA_RS14795	COG1741	Belongs to the pirin family
AFA_RS14800	COG3706	GGDEF domain
AFA_RS14805	COG0154	amidase activity
AFA_RS14815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFA_RS14830	COG0284	orotidine-5'-phosphate decarboxylase activity
AFA_RS14845	COG1414	Transcriptional regulator
AFA_RS14855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFA_RS14860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFA_RS14865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFA_RS14870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFA_RS14895	COG0742	ribosomal rna small subunit methyltransferase
AFA_RS14900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFA_RS14905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFA_RS14935	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AFA_RS14950	COG1335	isochorismatase
AFA_RS14955	COG2309	aminopeptidase activity
AFA_RS14960	COG0596	Alpha beta hydrolase
AFA_RS14965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFA_RS14965	COG2010	Cytochrome c
AFA_RS14970	COG2080	2 iron, 2 sulfur cluster binding
AFA_RS14975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFA_RS14975	COG2010	Cytochrome c
AFA_RS14985	COG0410	ABC transporter
AFA_RS14990	COG0411	ABC transporter
AFA_RS15000	COG0683	leucine binding
AFA_RS15010	COG3706	GGDEF domain
AFA_RS15025	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS15035	COG1234	tRNA 3'-trailer cleavage
AFA_RS15040	COG2188	Transcriptional regulator
AFA_RS15050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFA_RS15060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFA_RS15060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFA_RS15065	COG3608	succinylglutamate desuccinylase aspartoacylase
AFA_RS15065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFA_RS15070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AFA_RS15095	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AFA_RS15120	COG1335	isochorismatase
AFA_RS15125	COG2309	aminopeptidase activity
AFA_RS15130	COG0596	Alpha beta hydrolase
AFA_RS15145	COG1120	ATPase activity
AFA_RS15150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFA_RS15160	COG4206	TonB-dependent receptor
AFA_RS15165	COG2031	fatty acid transporter
AFA_RS15185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFA_RS15190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS15195	COG0328	RNA-DNA hybrid ribonuclease activity
AFA_RS15200	COG2226	methyltransferase
AFA_RS15205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFA_RS15210	COG0741	lytic transglycosylase activity
AFA_RS15210	COG1388	LysM domain
AFA_RS15220	COG2204	response regulator
AFA_RS15225	COG4191	Histidine kinase
AFA_RS15230	COG1301	dicarboxylic acid transport
AFA_RS15240	COG1054	Belongs to the UPF0176 family
AFA_RS15260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFA_RS15285	COG0604	alcohol dehydrogenase
AFA_RS15295	COG1024	Enoyl-CoA hydratase
AFA_RS15315	COG1902	pentaerythritol trinitrate reductase activity
AFA_RS15340	COG0583	DNA-binding transcription factor activity
AFA_RS15345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFA_RS15350	COG1454	alcohol dehydrogenase
AFA_RS15370	COG0583	DNA-binding transcription factor activity
AFA_RS15410	COG1393	Belongs to the ArsC family
AFA_RS15415	COG0431	NADPH-dependent FMN reductase
AFA_RS15420	COG0745	RESPONSE REGULATOR receiver
AFA_RS15425	COG0642	Histidine kinase
AFA_RS15445	COG2814	Major facilitator Superfamily
AFA_RS15470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFA_RS15470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFA_RS15475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFA_RS15480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFA_RS15485	COG1881	PFAM PEBP family protein
AFA_RS15490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFA_RS15495	COG0739	heme binding
AFA_RS15500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AFA_RS15515	COG0316	Belongs to the HesB IscA family
AFA_RS15525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFA_RS15530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFA_RS15535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFA_RS15540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AFA_RS15545	COG0312	modulator of DNA gyrase
AFA_RS15550	COG3028	Belongs to the UPF0307 family
AFA_RS15580	COG4566	intracellular signal transduction
AFA_RS15585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFA_RS15590	COG4681	YaeQ
AFA_RS15615	COG0762	integral membrane protein
AFA_RS15620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFA_RS15620	COG2169	Transcriptional regulator
AFA_RS15625	COG3133	Outer membrane lipoprotein
AFA_RS15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFA_RS15645	COG0439	Biotin carboxylase
AFA_RS15650	COG0511	ligase activity, forming carbon-carbon bonds
AFA_RS15655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFA_RS15660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFA_RS15665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFA_RS15670	COG3150	esterase
AFA_RS15685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFA_RS15690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFA_RS15700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFA_RS15715	COG1678	Uncharacterized ACR, COG1678
AFA_RS15730	COG0352	thiamine-phosphate diphosphorylase activity
AFA_RS15735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFA_RS15750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFA_RS15760	COG3237	CsbD-like
AFA_RS15765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFA_RS15770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFA_RS15775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFA_RS15780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFA_RS15805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFA_RS15820	COG1126	abc transporter atp-binding protein
AFA_RS15825	COG0765	amino acid transport
AFA_RS15830	COG4597	amino acid ABC transporter
AFA_RS15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFA_RS15840	COG2884	Cell division ATP-binding protein ftsE
AFA_RS15845	COG2177	Part of the ABC transporter FtsEX involved in
AFA_RS15855	COG0772	Belongs to the SEDS family
AFA_RS15860	COG0768	penicillin binding
AFA_RS15870	COG1792	Involved in formation and maintenance of cell shape
AFA_RS15875	COG1077	Cell shape determining protein MreB Mrl
AFA_RS15880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFA_RS15885	COG0154	amidase activity
AFA_RS15890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFA_RS15895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFA_RS15900	COG0583	DNA-binding transcription factor activity
AFA_RS15905	COG2259	Doxx family
AFA_RS15910	COG3384	dioxygenase
AFA_RS15920	COG3245	cytochrome
AFA_RS15930	COG1846	Transcriptional regulator
AFA_RS15935	COG1960	acyl-CoA dehydrogenase activity
AFA_RS15940	COG2814	Major facilitator Superfamily
AFA_RS15950	COG1024	Enoyl-CoA hydratase
AFA_RS15965	COG3604	Transcriptional regulator
AFA_RS15985	COG1309	transcriptional regulator
AFA_RS16000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFA_RS16025	COG1090	epimerase
AFA_RS16030	COG0786	glutamate:sodium symporter activity
AFA_RS16035	COG0142	geranyltranstransferase activity
AFA_RS16045	COG0494	nUDIX hydrolase
AFA_RS16050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFA_RS16075	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AFA_RS16080	COG0237	dephospho-CoA kinase activity
AFA_RS16090	COG2197	response regulator
AFA_RS16095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFA_RS16100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFA_RS16110	COG0477	Major facilitator Superfamily
AFA_RS16140	COG4206	TonB-dependent receptor
AFA_RS16145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFA_RS16160	COG1595	DNA-templated transcription, initiation
AFA_RS16170	COG2022	thiamine diphosphate biosynthetic process
AFA_RS16175	COG0351	phosphomethylpyrimidine kinase
AFA_RS16180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFA_RS16185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFA_RS16190	COG1538	Outer membrane efflux protein
AFA_RS16195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFA_RS16205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFA_RS16220	COG2226	methyltransferase
AFA_RS16225	COG0745	RESPONSE REGULATOR receiver
AFA_RS16230	COG5002	protein histidine kinase activity
AFA_RS16240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AFA_RS16245	COG1984	allophanate hydrolase subunit 2
AFA_RS16250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFA_RS16255	COG1238	metal cluster binding
AFA_RS16295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AFA_RS16300	COG4988	ABC transporter
AFA_RS16310	COG1294	oxidase, subunit
AFA_RS16315	COG1271	oxidase subunit
AFA_RS16330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFA_RS16345	COG1137	ATPase activity
AFA_RS16355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFA_RS16360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFA_RS16365	COG1660	Displays ATPase and GTPase activities
AFA_RS16375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFA_RS16380	COG0792	nuclease activity
AFA_RS16385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFA_RS16400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFA_RS16410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFA_RS16415	COG0793	Belongs to the peptidase S41A family
AFA_RS16420	COG4942	peptidase
AFA_RS16425	COG0588	phosphoglycerate mutase activity
AFA_RS16430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFA_RS16440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AFA_RS16445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFA_RS16450	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS16455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFA_RS16460	COG1040	competence protein
AFA_RS16465	COG2226	methyltransferase
AFA_RS16475	COG2204	response regulator
AFA_RS16495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFA_RS16505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFA_RS16510	COG3473	Maleate cis-trans isomerase
AFA_RS16525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFA_RS16540	COG0463	Glycosyl transferase, family 2
AFA_RS16545	COG0438	transferase activity, transferring glycosyl groups
AFA_RS16555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFA_RS16580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFA_RS16595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFA_RS16605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFA_RS16610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFA_RS16615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFA_RS16630	COG0356	it plays a direct role in the translocation of protons across the membrane
AFA_RS16640	COG1024	Enoyl-CoA hydratase
AFA_RS16655	COG0037	tRNA processing
AFA_RS16660	COG0163	prenyltransferase activity
AFA_RS16665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AFA_RS16670	COG2890	protein-(glutamine-N5) methyltransferase activity
AFA_RS16705	COG4773	Receptor
AFA_RS16735	COG3180	Ammonia monooxygenase
AFA_RS16755	COG5002	protein histidine kinase activity
AFA_RS16770	COG0477	Major facilitator Superfamily
AFA_RS16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFA_RS16795	COG1116	anion transmembrane transporter activity
AFA_RS16820	COG3383	formate dehydrogenase (NAD+) activity
AFA_RS16820	COG0243	molybdopterin cofactor binding
AFA_RS16825	COG3383	formate dehydrogenase (NAD+) activity
AFA_RS16825	COG0243	molybdopterin cofactor binding
AFA_RS16830	COG0437	4 iron, 4 sulfur cluster binding
AFA_RS16835	COG2864	formate dehydrogenase
AFA_RS16840	COG3058	Necessary for formate dehydrogenase activity
AFA_RS16845	COG1921	L-seryl-tRNASec selenium transferase activity
AFA_RS16850	COG3276	selenocysteine insertion sequence binding
AFA_RS16860	COG1476	TRANSCRIPTIONal
AFA_RS16865	COG0235	Class ii aldolase
AFA_RS16875	COG3181	Tripartite tricarboxylate transporter family receptor
AFA_RS16895	COG0709	Synthesizes selenophosphate from selenide and ATP
AFA_RS16900	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AFA_RS16905	COG0348	domain, Protein
AFA_RS16905	COG3901	Regulator of nitric oxide reductase transcription
AFA_RS16910	COG4263	nitrous-oxide reductase activity
AFA_RS16925	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AFA_RS16940	COG0166	Belongs to the GPI family
AFA_RS16965	COG1215	transferase activity, transferring glycosyl groups
AFA_RS16975	COG0297	glycogen (starch) synthase activity
AFA_RS17000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AFA_RS17035	COG0156	8-amino-7-oxononanoate synthase activity
AFA_RS17040	COG3321	synthase
AFA_RS17040	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS17040	COG0604	alcohol dehydrogenase
AFA_RS17045	COG2233	PERMEase
AFA_RS17050	COG0697	spore germination
AFA_RS17055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS17060	COG0697	spore germination
AFA_RS17070	COG0183	Belongs to the thiolase family
AFA_RS17075	COG1024	Enoyl-CoA hydratase
AFA_RS17075	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFA_RS17090	COG1127	ABC transporter
AFA_RS17095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFA_RS17100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFA_RS17115	COG1131	(ABC) transporter
AFA_RS17120	COG0842	Transport permease protein
AFA_RS17130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFA_RS17140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFA_RS17145	COG0131	Imidazoleglycerol-phosphate dehydratase
AFA_RS17155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFA_RS17160	COG0107	imidazoleglycerol-phosphate synthase activity
AFA_RS17170	COG0140	phosphoribosyl-ATP diphosphatase activity
AFA_RS17175	COG0537	adenosine 5'-monophosphoramidase activity
AFA_RS17180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFA_RS17185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFA_RS17195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFA_RS17205	COG1970	mechanosensitive ion channel activity
AFA_RS17210	COG0723	plastoquinol--plastocyanin reductase activity
AFA_RS17215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFA_RS17220	COG2857	Cytochrome c1
AFA_RS17225	COG0625	glutathione transferase activity
AFA_RS17230	COG2969	positive regulation of protein catabolic process
AFA_RS17235	COG4208	sulfate ABC transporter
AFA_RS17240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFA_RS17245	COG4150	thiosulfate binding
AFA_RS17275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFA_RS17295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AFA_RS17300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFA_RS17305	COG3622	Belongs to the hyi family
AFA_RS17310	COG2084	Dehydrogenase
AFA_RS17315	COG0129	dihydroxy-acid dehydratase activity
AFA_RS17320	COG1802	Transcriptional regulator
AFA_RS17325	COG1522	sequence-specific DNA binding
AFA_RS17330	COG3483	tryptophan 2,3-dioxygenase activity
AFA_RS17350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFA_RS17355	COG0656	L-ascorbic acid biosynthetic process
AFA_RS17365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFA_RS17370	COG3706	GGDEF domain
AFA_RS17375	COG2226	methyltransferase
AFA_RS17385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFA_RS17400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AFA_RS17405	COG0583	DNA-binding transcription factor activity
AFA_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
AFA_RS17415	COG1335	isochorismatase
AFA_RS17435	COG2823	Periplasmic or secreted lipoprotein
AFA_RS17445	COG3284	Transcriptional regulator
AFA_RS17475	COG1595	DNA-templated transcription, initiation
AFA_RS17490	COG1522	sequence-specific DNA binding
AFA_RS17505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFA_RS17525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFA_RS17560	COG0109	protoheme IX farnesyltransferase activity
AFA_RS17565	COG2207	Transcriptional regulator
AFA_RS17565	COG4753	response regulator
AFA_RS17610	COG3568	Endonuclease Exonuclease Phosphatase
AFA_RS17615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFA_RS17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFA_RS17650	COG1228	amidohydrolase
AFA_RS17670	COG2986	histidine ammonia-lyase
AFA_RS17675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFA_RS17700	COG0789	Transcriptional regulator
AFA_RS17720	COG0625	glutathione transferase activity
AFA_RS17745	COG1448	Aminotransferase
AFA_RS17750	COG2365	Tyrosine phosphatase family
AFA_RS17755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFA_RS17775	COG2423	ornithine cyclodeaminase activity
AFA_RS17825	COG3069	C4-dicarboxylate transmembrane transporter activity
AFA_RS17835	COG1802	Transcriptional regulator
AFA_RS17845	COG2814	Major facilitator Superfamily
AFA_RS17860	COG2814	Major facilitator Superfamily
AFA_RS17870	COG2814	Major facilitator Superfamily
AFA_RS17880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFA_RS17885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFA_RS17890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFA_RS17910	COG5001	Diguanylate cyclase
AFA_RS17910	COG5002	protein histidine kinase activity
AFA_RS17915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFA_RS17920	COG1333	cytochrome c biogenesis protein
AFA_RS17930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFA_RS17940	COG4232	protein-disulfide reductase activity
AFA_RS17960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFA_RS17965	COG0203	ribosomal protein L17
AFA_RS17970	COG0202	RNA polymerase activity
AFA_RS17975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFA_RS17980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFA_RS17985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFA_RS17990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFA_RS18000	COG0201	protein transport
AFA_RS18005	COG0200	Binds to the 23S rRNA
AFA_RS18010	COG1841	ribosomal large subunit assembly
AFA_RS18015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFA_RS18020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFA_RS18025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFA_RS18030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFA_RS18035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFA_RS18040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFA_RS18045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFA_RS18050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFA_RS18075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFA_RS18080	COG2274	protein secretion by the type I secretion system
AFA_RS18090	COG1538	Outer membrane efflux protein
AFA_RS18115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AFA_RS18125	COG0647	UMP catabolic process
AFA_RS18130	COG1737	Transcriptional regulator
AFA_RS18145	COG1960	acyl-CoA dehydrogenase activity
AFA_RS18150	COG0183	Belongs to the thiolase family
AFA_RS18160	COG2067	long-chain fatty acid transport protein
AFA_RS18175	COG0318	PFAM AMP-dependent synthetase and ligase
AFA_RS18180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFA_RS18185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFA_RS18190	COG1648	precorrin-2 dehydrogenase activity
AFA_RS18190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFA_RS18205	COG1116	anion transmembrane transporter activity
AFA_RS18210	COG1960	acyl-CoA dehydrogenase activity
AFA_RS18225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFA_RS18230	COG0255	Belongs to the universal ribosomal protein uL29 family
AFA_RS18235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFA_RS18240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFA_RS18245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFA_RS18250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFA_RS18255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFA_RS18260	COG0089	rRNA binding
AFA_RS18265	COG0088	Forms part of the polypeptide exit tunnel
AFA_RS18270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFA_RS18275	COG4175	Glycine betaine
AFA_RS18280	COG4176	ABC-type proline glycine betaine transport system permease component
AFA_RS18285	COG0051	transcription antitermination factor activity, RNA binding
AFA_RS18290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFA_RS18295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFA_RS18300	COG0049	tRNA binding
AFA_RS18305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFA_RS18335	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AFA_RS18340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFA_RS18345	COG0085	RNA polymerase activity
AFA_RS18350	COG0222	ribosome binding
AFA_RS18355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFA_RS18360	COG0081	regulation of translation
AFA_RS18385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFA_RS18405	COG1475	DNA binding
AFA_RS18410	COG1192	Involved in chromosome partitioning
AFA_RS18415	COG0357	Ribosomal RNA small subunit methyltransferase G
AFA_RS18420	COG0445	tRNA wobble uridine modification
AFA_RS18425	COG0436	Aminotransferase
AFA_RS18430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFA_RS18435	COG3706	GGDEF domain
AFA_RS18440	COG0688	phosphatidylethanolamine metabolic process
AFA_RS18450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFA_RS18495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFA_RS18530	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFA_RS18550	COG0596	Alpha beta hydrolase
AFA_RS18555	COG2309	aminopeptidase activity
AFA_RS18560	COG1335	isochorismatase
AFA_RS18585	COG0753	catalase activity
AFA_RS18590	COG0706	membrane insertase activity
AFA_RS18595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFA_RS18600	COG0594	ribonuclease P activity
AFA_RS18605	COG0230	Belongs to the bacterial ribosomal protein bL34 family