locus-tag class description GWQ43_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GWQ43_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GWQ43_RS00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWQ43_RS00020 ENOG4105I08 Pseudouridine synthase GWQ43_RS00035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00060 ENOG4108Z9W Outer membrane porin GWQ43_RS00065 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GWQ43_RS00115 ENOG4105C1G acyl-Coa dehydrogenase GWQ43_RS00125 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWQ43_RS00135 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWQ43_RS00145 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00165 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GWQ43_RS00180 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS00185 ENOG4107XBN GntR Family Transcriptional Regulator GWQ43_RS00190 ENOG4108Z9W Outer membrane porin GWQ43_RS00195 ENOG4105CSP Major Facilitator Superfamily GWQ43_RS00200 ENOG4105CWC Acetylornithine deacetylase GWQ43_RS00215 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS00220 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GWQ43_RS00225 ENOG4108IV0 ABC, transporter GWQ43_RS00230 ENOG4105CEY Amp-dependent synthetase and ligase GWQ43_RS00240 ENOG4107TTQ Alpha beta hydrolase fold GWQ43_RS00245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS00270 ENOG4108Q5Y Membrane GWQ43_RS00275 ENOG4105CVI Transcriptional regulator GWQ43_RS00285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS00305 ENOG4105CKI cobalamin synthesis protein GWQ43_RS00360 ENOG4108SY4 MarR family Transcriptional regulator GWQ43_RS00380 ENOG4105ERH Fumarylacetoacetate hydrolase GWQ43_RS00385 ENOG4105ES4 Nitrilase GWQ43_RS00390 ENOG4106IPI cyclase, family GWQ43_RS00395 ENOG4105E3J oxidoreductase GWQ43_RS00400 ENOG4105FUY alpha subunit GWQ43_RS00425 ENOG4105CHR reductase GWQ43_RS00435 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00455 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GWQ43_RS00485 ENOG4108JEH abc transporter atp-binding protein GWQ43_RS00490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GWQ43_RS00495 ENOG4105CNM Receptor GWQ43_RS00505 ENOG4108SF5 RNA Polymerase GWQ43_RS00510 ENOG4108JQ7 (ABC) transporter GWQ43_RS00515 ENOG4105C3U ABC transporter GWQ43_RS00520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWQ43_RS00525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GWQ43_RS00530 ENOG4105DEF Extracellular solute-binding protein, family 5 GWQ43_RS00540 ENOG4108SF5 RNA Polymerase GWQ43_RS00545 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS00550 ENOG4105E0K tonB-dependent siderophore receptor GWQ43_RS00555 ENOG4105FQP Beta-lactamase GWQ43_RS00560 ENOG4105C8Y Acetylornithine aminotransferase GWQ43_RS00575 ENOG4105D01 (LipO)protein GWQ43_RS00580 ENOG4105D01 (LipO)protein GWQ43_RS00585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS00590 ENOG4108UMI ABC transporter, permease GWQ43_RS00595 ENOG4107T8P acyl-Coa dehydrogenase GWQ43_RS00605 ENOG4105D01 (LipO)protein GWQ43_RS00615 ENOG4105D01 (LipO)protein GWQ43_RS00625 ENOG4108C33 Resolvase GWQ43_RS00645 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GWQ43_RS00650 ENOG4108UZX fmn reductase GWQ43_RS00675 ENOG4105ETT transcriptional Regulator, LysR family GWQ43_RS00680 ENOG4107XWS modD protein GWQ43_RS00685 ENOG4105E0C molybdate abc transporter GWQ43_RS00695 ENOG4107QP3 malate synthase g GWQ43_RS00700 ENOG4105FYV Amp nucleosidase GWQ43_RS00710 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GWQ43_RS00715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00730 ENOG4105C7K acetolactate synthase GWQ43_RS00735 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GWQ43_RS00745 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00755 ENOG4105C9U ATP-dependent DNA helicase RecQ GWQ43_RS00765 ENOG4108RPN Protein smg homolog GWQ43_RS00785 ENOG4107QX3 carboxylase GWQ43_RS00790 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS00795 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) GWQ43_RS00800 ENOG4105C1G acyl-Coa dehydrogenase GWQ43_RS00820 ENOG4108Z33 Thiol disulfide Interchange Protein GWQ43_RS00830 ENOG4105C75 arginyL-tRNA synthetase GWQ43_RS00850 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GWQ43_RS00865 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWQ43_RS00875 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GWQ43_RS00880 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GWQ43_RS00885 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GWQ43_RS00890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWQ43_RS00895 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS00905 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS00910 ENOG4108UAU isochorismatase GWQ43_RS00915 ENOG4107R11 Transcriptional regulator GWQ43_RS00925 ENOG4108UQY Iron-storage protein GWQ43_RS00935 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GWQ43_RS00940 ENOG410829K Lysine exporter protein (Lyse ygga) GWQ43_RS00945 ENOG4105C1J atp-dependent rna helicase GWQ43_RS00955 ENOG4105HA9 of methanol dehydrogenase type GWQ43_RS00970 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GWQ43_RS00985 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS01000 ENOG4105CVI Transcriptional regulator GWQ43_RS01020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS01035 ENOG4105DHJ ABC, transporter GWQ43_RS01040 ENOG4108SNX Mammalian cell entry related domain protein GWQ43_RS01055 ENOG4107YBY Hydrolase GWQ43_RS01060 ENOG4108NDG TRAP dicarboxylate GWQ43_RS01070 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS01100 ENOG4105RQF LysR family Transcriptional regulator GWQ43_RS01105 ENOG4105MWK D-amino acid dehydrogenase, small subunit GWQ43_RS01115 ENOG4105CGY Dna recombination protein GWQ43_RS01120 ENOG41082AG Plasmid maintenance system antidote protein GWQ43_RS01130 ENOG4105BZU Histidine kinase GWQ43_RS01145 ENOG4105H1G trap transporter solute receptor taxi family GWQ43_RS01155 ENOG4105D3G Pseudouridine synthase GWQ43_RS01160 ENOG4105HDK L-asparaginase GWQ43_RS01180 ENOG4108JEH abc transporter atp-binding protein GWQ43_RS01185 ENOG4105D82 Glutamate dehydrogenase GWQ43_RS01190 ENOG4105DFA alanine racemase domain protein GWQ43_RS01210 ENOG4105C0Z ABC transporter GWQ43_RS01215 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS01230 ENOG4108IV0 ABC, transporter GWQ43_RS01240 ENOG4107QXX ABC transporter GWQ43_RS01250 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS01265 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GWQ43_RS01270 ENOG4105C79 DNA protecting protein DprA GWQ43_RS01275 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GWQ43_RS01280 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GWQ43_RS01300 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS01315 ENOG4105CFM UPF0317 protein GWQ43_RS01320 ENOG4105SKE transcriptional Regulator LysR family GWQ43_RS01325 ENOG4105D16 lipopolysaccharide heptosyltransferase i GWQ43_RS01330 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GWQ43_RS01335 ENOG4105VEQ Cold shock protein GWQ43_RS01340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GWQ43_RS01345 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GWQ43_RS01350 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GWQ43_RS01360 ENOG4105DZ1 carboxypeptidase GWQ43_RS01365 ENOG4105F0I Aminotransferase GWQ43_RS01370 ENOG4108Z43 UPF0250 protein GWQ43_RS01375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GWQ43_RS01395 ENOG4105E39 Enoyl-CoA hydratase GWQ43_RS01400 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GWQ43_RS01410 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GWQ43_RS01490 ENOG4105DK0 Indole-3-glycerol phosphate synthase GWQ43_RS01495 ENOG4108I0Q anthranilate phosphoribosyltransferase GWQ43_RS01500 ENOG4105DDQ anthranilate synthase GWQ43_RS01510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GWQ43_RS01525 ENOG4105NWN ApaG protein GWQ43_RS01530 ENOG4105CA3 membrane-bound lytic murein transglycosylase GWQ43_RS01535 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GWQ43_RS01540 ENOG4105T95 Thiol disulfide interChange protein GWQ43_RS01550 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS01560 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GWQ43_RS01565 ENOG4105WQI isochorismatase GWQ43_RS01570 ENOG4105E4F Isochorismate synthase GWQ43_RS01585 ENOG4105C0W non-ribosomal peptide synthetase GWQ43_RS01590 ENOG4105WQI isochorismatase GWQ43_RS01595 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GWQ43_RS01605 ENOG4108IV0 ABC, transporter GWQ43_RS01610 ENOG4105C0Z ABC transporter GWQ43_RS01625 ENOG4105CAD extracellular ligand-binding receptor GWQ43_RS01640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS01675 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS01680 ENOG4105EHG Permease protein GWQ43_RS01685 ENOG4105NIV Esterase GWQ43_RS01690 ENOG4105C1J atp-dependent rna helicase GWQ43_RS01695 ENOG4105C2C drug resistance transporter, Bcr CflA GWQ43_RS01705 ENOG4108PTX LysR family Transcriptional regulator GWQ43_RS01715 ENOG4105EE5 Membrane protein terC GWQ43_RS01725 ENOG4105EUB pirin domain protein GWQ43_RS01775 ENOG4108MTT Glutamate-rich protein grpB GWQ43_RS01780 ENOG4105K5X acetyltransferase GWQ43_RS01800 ENOG4107XC4 flavin reductase domain protein, FMN-binding GWQ43_RS01820 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS01835 ENOG4105RQF LysR family Transcriptional regulator GWQ43_RS01840 ENOG4105EAB amino acid AbC transporter GWQ43_RS01850 ENOG4105DRP amino acid AbC transporter GWQ43_RS01855 ENOG4105EAD ABC transporter GWQ43_RS01870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GWQ43_RS01920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GWQ43_RS01925 ENOG4105C25 Primosomal protein n' GWQ43_RS01930 ENOG4105C4R Atp-dependent dna helicase GWQ43_RS01950 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase GWQ43_RS01960 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWQ43_RS01965 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWQ43_RS01975 ENOG4105MPD Cytochrome GWQ43_RS01990 ENOG4105UGU tonB-dependent Receptor GWQ43_RS01995 ENOG4105D9M gamma-glutamylcysteine synthetase GWQ43_RS02005 ENOG4105VJY transcriptional regulator GWQ43_RS02010 ENOG4105DWV Homoserine O-trans-acetylase GWQ43_RS02020 ENOG4105EYM Major Facilitator superfamily GWQ43_RS02025 ENOG4105EN6 Membrane GWQ43_RS02030 ENOG41067MG lrgb family GWQ43_RS02040 ENOG4105KME endoribonuclease L-psp GWQ43_RS02045 ENOG4105KME endoribonuclease L-psp GWQ43_RS02080 ENOG4105CCF Lysine exporter protein (Lyse ygga) GWQ43_RS02090 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GWQ43_RS02095 ENOG4105EXG Transcriptional regulator GWQ43_RS02105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GWQ43_RS02120 ENOG4108WBT adenosyltransferase GWQ43_RS02135 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GWQ43_RS02140 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GWQ43_RS02150 ENOG4105CKI cobalamin synthesis protein GWQ43_RS02155 ENOG4105MYN Zinc uptake regulation protein GWQ43_RS02160 ENOG4105DIK (ABC) transporter GWQ43_RS02165 ENOG4105CC5 ABC transporter GWQ43_RS02170 ENOG4105DSE periplasmic solute binding protein GWQ43_RS02175 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWQ43_RS02185 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GWQ43_RS02190 ENOG4105D1S lipid A biosynthesis GWQ43_RS02200 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GWQ43_RS02205 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GWQ43_RS02210 ENOG41082T9 Membrane GWQ43_RS02215 ENOG4105SYT Methylenetetrahydrofolate reductase GWQ43_RS02225 ENOG4107SC1 transglycosylase GWQ43_RS02245 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GWQ43_RS02250 ENOG4108VCT Sulfite exporter TauE/SafE GWQ43_RS02255 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GWQ43_RS02260 ENOG4105C01 Dihydroxy-acid dehydratase GWQ43_RS02270 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GWQ43_RS02280 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS02285 ENOG4105DV0 amidase (EC 3.5.1.4 GWQ43_RS02295 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GWQ43_RS02325 ENOG4105IPI Membrane GWQ43_RS02335 ENOG4108Z9W Outer membrane porin GWQ43_RS02340 ENOG4105CV8 reductase GWQ43_RS02345 ENOG4105F27 Major Facilitator GWQ43_RS02350 ENOG4105HEI LysR family (Transcriptional regulator GWQ43_RS02360 ENOG4108N8X transition metal ion binding GWQ43_RS02380 ENOG4105GVJ transcriptional regulator GWQ43_RS02385 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GWQ43_RS02395 ENOG4105C1P efflux transporter, rnd family, mfp subunit GWQ43_RS02425 ENOG4108IPW abc transporter atp-binding protein GWQ43_RS02450 ENOG4105CXG d-lactate dehydrogenase GWQ43_RS02460 ENOG41073TP transcriptional regulator GWQ43_RS02465 ENOG4105DAA L-lactate GWQ43_RS02480 ENOG4105CZE histidine utilization repressor GWQ43_RS02485 ENOG4105F7P transcriptional regulator AsnC family GWQ43_RS02490 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GWQ43_RS02495 ENOG4105C85 amino acid GWQ43_RS02535 ENOG4105E98 transcriptional regulator DeoR family GWQ43_RS02540 ENOG4108IJ9 (ABC) transporter GWQ43_RS02545 ENOG4105BZ7 extracellular solute-binding protein family 1 GWQ43_RS02555 ENOG4105DRS transport system, permease GWQ43_RS02580 ENOG4108ZCF integral membrane protein GWQ43_RS02585 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GWQ43_RS02595 ENOG4108UPT UPF0178 protein GWQ43_RS02605 ENOG41084HI prevent-host-death family GWQ43_RS02615 ENOG4105EST Metal Dependent Phosphohydrolase GWQ43_RS02625 ENOG4105CXK mandelate racemase muconate lactonizing GWQ43_RS02630 ENOG4105VEJ Heat shock protein GWQ43_RS02635 ENOG4105C57 major facilitator superfamily GWQ43_RS02640 ENOG41064MX Tetr family transcriptional regulator GWQ43_RS02650 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS02660 ENOG4107RSM transcriptional regulator GWQ43_RS02675 ENOG4105N0V mono-oxygenase ydhR GWQ43_RS02685 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GWQ43_RS02690 ENOG4108ESX Receptor GWQ43_RS02695 ENOG4107E2E PKHD-type hydroxylase GWQ43_RS02720 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GWQ43_RS02725 ENOG4109066 lysm domain bon superfamily protein GWQ43_RS02730 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GWQ43_RS02740 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GWQ43_RS02750 ENOG4105DFP Integrase GWQ43_RS02800 ENOG4107YH6 single-stranded DNA-binding protein GWQ43_RS02805 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GWQ43_RS02965 ENOG4105W5Q DNA repair protein (RadC GWQ43_RS03000 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression GWQ43_RS03080 ENOG4108BUD transposase GWQ43_RS03125 ENOG4105E0A ABC, transporter GWQ43_RS03140 ENOG4108HFV GWQ43_RS03150 ENOG4105C0D helicase GWQ43_RS03160 ENOG4106NZI LysR family Transcriptional regulator GWQ43_RS03200 ENOG4105WQI isochorismatase GWQ43_RS03225 ENOG4105CBN LysR family transcriptional regulator GWQ43_RS03230 ENOG4105EWV Sodium calcium exchanger membrane region GWQ43_RS03245 ENOG4105CSH Transporter GWQ43_RS03250 ENOG4108S8N class II Aldolase GWQ43_RS03260 ENOG4108NS2 receptor GWQ43_RS03265 ENOG4107Y2X deaminase GWQ43_RS03270 ENOG4105S0E allantoin catabolism protein GWQ43_RS03275 ENOG4108M0I Transcriptional regulator GWQ43_RS03285 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GWQ43_RS03295 ENOG4105D1F ATP-binding protein GWQ43_RS03315 ENOG4105CXN decarboxylase GWQ43_RS03320 ENOG4105CBX hi0933 family GWQ43_RS03325 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GWQ43_RS03335 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GWQ43_RS03340 ENOG4108UKZ OsmC family GWQ43_RS03345 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GWQ43_RS03370 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) GWQ43_RS03375 ENOG4105CA9 Pyruvate kinase GWQ43_RS03380 ENOG4108ZJF Glcg protein GWQ43_RS03390 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GWQ43_RS03395 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GWQ43_RS03400 ENOG41060W2 glyoxylate carboligase GWQ43_RS03405 ENOG4105EJC lysr family transcriptional regulator GWQ43_RS03415 ENOG4105C2W permease GWQ43_RS03420 ENOG41084KP 4-oxalocrotonate tautomerase GWQ43_RS03425 ENOG4105MP9 class II Aldolase GWQ43_RS03435 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GWQ43_RS03445 ENOG4107UKG Glycosyl transferase, family 4 GWQ43_RS03450 ENOG4107QQG Dehydrogenase GWQ43_RS03465 ENOG4105CG5 Glycosyl transferase (Group 1 GWQ43_RS03470 ENOG4107XU6 Glycosyl transferase (Group 1 GWQ43_RS03475 ENOG4105CGN Glycosyl transferase (Group 1 GWQ43_RS03485 ENOG4105CQB FAD linked oxidase domain protein GWQ43_RS03495 ENOG4105ERH Fumarylacetoacetate hydrolase GWQ43_RS03500 ENOG4105F1J Homogentisate 1,2-dioxygenase GWQ43_RS03510 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GWQ43_RS03520 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GWQ43_RS03530 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GWQ43_RS03545 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GWQ43_RS03550 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GWQ43_RS03555 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GWQ43_RS03565 ENOG4105C3G gtp-binding protein GWQ43_RS03570 ENOG4105DFP Integrase GWQ43_RS03580 ENOG4108I5C dEAD DEAH box helicase GWQ43_RS03585 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GWQ43_RS03645 ENOG4106JUT Streptomycin 3''-adenylyltransferase GWQ43_RS03650 ENOG4105C5H ABC transporter GWQ43_RS03665 ENOG4107B2H carbonic anhydrase GWQ43_RS03670 ENOG4105DND Transcriptional regulator GWQ43_RS03685 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GWQ43_RS03690 ENOG41060IM Heme exporter protein GWQ43_RS03700 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GWQ43_RS03705 ENOG4105DA4 cytochrome c-type biogenesis protein GWQ43_RS03710 ENOG4107QX9 Thiol disulfide interChange protein GWQ43_RS03715 ENOG4105KWW Biogenesis protein GWQ43_RS03720 ENOG4108M1T Cytochrome c-type biogenesis protein GWQ43_RS03725 ENOG4107QIV Cytochrome c biogenesis protein GWQ43_RS03735 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GWQ43_RS03755 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS03760 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GWQ43_RS03765 ENOG4105C0Z ABC transporter GWQ43_RS03770 ENOG4108IV0 ABC, transporter GWQ43_RS03775 ENOG4105CA0 peroxidase GWQ43_RS03780 ENOG4108JQ1 Dehydrogenase GWQ43_RS03785 ENOG4105KPV Transcriptional regulator GWQ43_RS03790 ENOG4105VIG Sec-independent protein translocase protein TatC GWQ43_RS03835 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GWQ43_RS03840 ENOG4108IEG Formate dehydrogenase Alpha subunit GWQ43_RS03845 ENOG4107QIZ NADH dehydrogenase GWQ43_RS03855 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GWQ43_RS03860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GWQ43_RS03865 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GWQ43_RS03870 ENOG4105CVM Molybdenum cofactor synthesis domain protein GWQ43_RS03875 ENOG4108RIR Molybdenum cofactor biosynthesis protein GWQ43_RS03880 ENOG4108ZAF Molybdopterin GWQ43_RS03890 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GWQ43_RS03895 ENOG4108ZXC Two component transcriptional regulator, luxr family GWQ43_RS03900 ENOG4105BZU Histidine kinase GWQ43_RS03905 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GWQ43_RS03910 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component GWQ43_RS03915 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS03935 ENOG4108TZV Membrane GWQ43_RS03940 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GWQ43_RS03975 ENOG4105EQ0 Major Facilitator superfamily GWQ43_RS04010 ENOG4105BZU Histidine kinase GWQ43_RS04015 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GWQ43_RS04020 ENOG4108JU5 Magnesium and cobalt efflux protein GWQ43_RS04025 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GWQ43_RS04030 ENOG4105C9A Phoh family GWQ43_RS04035 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GWQ43_RS04045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GWQ43_RS04050 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GWQ43_RS04055 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GWQ43_RS04060 ENOG4105VIE preprotein translocase, subunit YajC GWQ43_RS04065 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GWQ43_RS04070 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GWQ43_RS04075 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GWQ43_RS04080 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GWQ43_RS04090 ENOG4105NE1 Conserved Protein GWQ43_RS04105 ENOG4105ETT transcriptional Regulator, LysR family GWQ43_RS04120 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GWQ43_RS04135 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS04145 ENOG4105CSH Transporter GWQ43_RS04160 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GWQ43_RS04170 ENOG4105CHM Aminotransferase GWQ43_RS04180 ENOG4105C6K Malic enzyme GWQ43_RS04190 ENOG41067XF inhibitor GWQ43_RS04195 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GWQ43_RS04200 ENOG4105CV1 Transketolase (EC 2.2.1.1) GWQ43_RS04205 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GWQ43_RS04210 ENOG4105BZA Phosphoglycerate kinase GWQ43_RS04230 ENOG4108RIR Molybdenum cofactor biosynthesis protein GWQ43_RS04240 ENOG4105C8V SAICAR synthetase GWQ43_RS04245 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GWQ43_RS04250 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GWQ43_RS04255 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GWQ43_RS04260 ENOG4108YIQ Alpha beta hydrolase GWQ43_RS04265 ENOG4105DXM phenylacetic acid degradation protein GWQ43_RS04270 ENOG4105C1G acyl-Coa dehydrogenase GWQ43_RS04275 ENOG4108MGI Transcriptional regulator GWQ43_RS04280 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GWQ43_RS04290 ENOG4105D5U fad dependent oxidoreductase GWQ43_RS04300 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GWQ43_RS04310 ENOG4105CUZ uba thif-type nad fad binding protein GWQ43_RS04320 ENOG4105CRQ synthase (Component I) GWQ43_RS04325 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GWQ43_RS04330 ENOG4108SHN Glycosyl transferase, family 2 GWQ43_RS04340 ENOG4105C5H ABC transporter GWQ43_RS04360 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GWQ43_RS04365 ENOG4107QMS site-determining protein GWQ43_RS04375 ENOG4105CX6 glutaminyL-tRNA synthetase GWQ43_RS04380 ENOG4105C4M (Ubiquinol oxidase) subunit I GWQ43_RS04385 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GWQ43_RS04400 ENOG4105C9U ATP-dependent DNA helicase RecQ GWQ43_RS04405 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWQ43_RS04410 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWQ43_RS04415 ENOG4105XPH Ferredoxin GWQ43_RS04420 ENOG4105C5H ABC transporter GWQ43_RS04430 ENOG4108V6E Cell division protein mraZ GWQ43_RS04435 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GWQ43_RS04440 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GWQ43_RS04445 ENOG4105CJN penicillin-binding protein GWQ43_RS04450 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GWQ43_RS04455 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GWQ43_RS04460 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GWQ43_RS04470 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GWQ43_RS04475 ENOG4105DFU Cell wall formation (By similarity) GWQ43_RS04480 ENOG4105CPF Cell wall formation (By similarity) GWQ43_RS04485 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GWQ43_RS04490 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GWQ43_RS04495 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GWQ43_RS04500 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GWQ43_RS04510 ENOG4105E4C Lytic transglycosylase catalytic GWQ43_RS04515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GWQ43_RS04525 ENOG4105CJW magnesium transporter GWQ43_RS04530 ENOG4105NAU thioesterase Superfamily protein GWQ43_RS04535 ENOG4105CH2 amidohydrolase GWQ43_RS04540 ENOG4105CEY Amp-dependent synthetase and ligase GWQ43_RS04545 ENOG4105ECY inositol monophosphatase GWQ43_RS04550 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GWQ43_RS04565 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS04570 ENOG4108UMI ABC transporter, permease GWQ43_RS04575 ENOG4105D01 (LipO)protein GWQ43_RS04580 ENOG4107R0W ABC transporter GWQ43_RS04585 ENOG4105E5Q amino acid AbC transporter GWQ43_RS04590 ENOG4105CDA abc transporter atp-binding protein GWQ43_RS04600 ENOG4108S0S Nucleotidyl transferase GWQ43_RS04605 ENOG4105EHM Aminoglycoside phosphotransferase GWQ43_RS04615 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GWQ43_RS04620 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GWQ43_RS04640 ENOG4105E9Q Acyl-transferase GWQ43_RS04645 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GWQ43_RS04650 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GWQ43_RS04655 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GWQ43_RS04665 ENOG4106YT9 Enoyl-CoA hydratase GWQ43_RS04670 ENOG4107GFK fumarate GWQ43_RS04675 ENOG4108IG5 Transcriptional regulator GWQ43_RS04700 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GWQ43_RS04710 ENOG4105DJ0 Poly(A) Polymerase GWQ43_RS04720 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GWQ43_RS04725 ENOG4105CXB phosphoribosylaminoimidazole synthetase GWQ43_RS04735 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GWQ43_RS04740 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GWQ43_RS04745 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GWQ43_RS04750 ENOG4105DQR SNARE associated Golgi GWQ43_RS04755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GWQ43_RS04760 ENOG4105K8N protein family UPF0079, ATPase GWQ43_RS04805 ENOG4105CKK Glycosyl transferase, family 2 GWQ43_RS04810 ENOG4105C6K Malic enzyme GWQ43_RS04815 ENOG4105DDW LysR family Transcriptional regulator GWQ43_RS04820 ENOG4105C26 Dehydrogenase GWQ43_RS04825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GWQ43_RS04835 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS04875 ENOG4105KVH Transcriptional regulator GWQ43_RS04880 ENOG4108RYK Nad-dependent epimerase dehydratase GWQ43_RS04895 ENOG4108Z66 YbaK ebsC protein GWQ43_RS04900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWQ43_RS04905 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GWQ43_RS04910 ENOG4105E0C molybdate abc transporter GWQ43_RS04915 ENOG4108IJ6 ABC transporter GWQ43_RS04920 ENOG4105F4R Transcriptional regulator mode GWQ43_RS04930 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GWQ43_RS04940 ENOG4107QMP dna polymerase iii subunits gamma and tau GWQ43_RS04955 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase GWQ43_RS04965 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS04985 ENOG4108NS2 receptor GWQ43_RS04990 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GWQ43_RS04995 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GWQ43_RS05000 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GWQ43_RS05025 ENOG4105C2W permease GWQ43_RS05030 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GWQ43_RS05035 ENOG4105HBR Rna-binding protein GWQ43_RS05040 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GWQ43_RS05045 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GWQ43_RS05055 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GWQ43_RS05065 ENOG4105C9X ppx gppa phosphatase GWQ43_RS05070 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GWQ43_RS05075 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GWQ43_RS05080 ENOG4105C8U phosphate abc transporter GWQ43_RS05085 ENOG4105E2Z phosphate ABC transporter (Permease GWQ43_RS05090 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS05095 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GWQ43_RS05110 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS05115 ENOG4105E0F Histidine kinase GWQ43_RS05150 ENOG4107TJ9 Cytochrome GWQ43_RS05155 ENOG4107VMU Membrane GWQ43_RS05170 ENOG4105E0M Sulfatase GWQ43_RS05200 ENOG4107QN1 sodium solute GWQ43_RS05205 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GWQ43_RS05210 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GWQ43_RS05225 ENOG4107RTD sua5 ycio yrdc ywlc family protein GWQ43_RS05230 ENOG4108Z4T Peptidase M50 GWQ43_RS05235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GWQ43_RS05240 ENOG4105GJM (LipO)protein GWQ43_RS05255 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GWQ43_RS05265 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GWQ43_RS05270 ENOG4106A3M Cytochrome p-450 GWQ43_RS05275 ENOG4105DKK Benzoate GWQ43_RS05285 ENOG4105EZE Cupin 4 family protein GWQ43_RS05295 ENOG4108NS2 receptor GWQ43_RS05330 ENOG4108Y1S CRISPR-associated protein, Csy4 family GWQ43_RS05335 ENOG4105DJY efflux transporter, rnd family, mfp subunit GWQ43_RS05340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWQ43_RS05345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GWQ43_RS05350 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GWQ43_RS05355 ENOG4105BZ1 (ABC) transporter GWQ43_RS05360 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GWQ43_RS05375 ENOG4105DEN Luciferase family GWQ43_RS05385 ENOG4105D64 Mechanosensitive ion channel GWQ43_RS05390 ENOG4108K70 Transcriptional regulator GWQ43_RS05430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS05435 ENOG4105CRW Short chain fatty acid transporter GWQ43_RS05450 ENOG4105ECY inositol monophosphatase GWQ43_RS05455 ENOG4105EE5 Membrane protein terC GWQ43_RS05460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GWQ43_RS05480 ENOG4105C8N cysteinyl-tRNA synthetase GWQ43_RS05490 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GWQ43_RS05495 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GWQ43_RS05500 ENOG4105CFH Aspartokinase GWQ43_RS05515 ENOG4105EPW hflc protein GWQ43_RS05545 ENOG4108XTP Transcriptional regulator GWQ43_RS05585 ENOG4107QRT dEAD DEAH box helicase GWQ43_RS05600 ENOG4105W5Q DNA repair protein (RadC GWQ43_RS05670 ENOG4105CMA conjugation trbi family protein GWQ43_RS05775 ENOG4105ECW sulfate abc transporter GWQ43_RS05780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS05785 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GWQ43_RS05790 ENOG4105W8H transhydrogenase (subunit alpha GWQ43_RS05795 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GWQ43_RS05810 ENOG4105E0F Histidine kinase GWQ43_RS05820 ENOG4105CNM Receptor GWQ43_RS05835 ENOG4105DMF Dehydrogenase GWQ43_RS05840 ENOG4105CHF Glutathione S-transferase GWQ43_RS05845 ENOG4105CS1 NAD(P)H quinone oxidoreductase GWQ43_RS05875 ENOG4105D7N magnesium and cobalt transport protein CorA GWQ43_RS05880 ENOG4105CSU acyl-Coa dehydrogenase GWQ43_RS05890 ENOG4105DEF Extracellular solute-binding protein, family 5 GWQ43_RS05900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWQ43_RS05905 ENOG4108JQ6 ABC transporter GWQ43_RS05915 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GWQ43_RS05920 ENOG4105C26 Dehydrogenase GWQ43_RS05925 ENOG4105C0A alcohol dehydrogenase GWQ43_RS05950 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS05955 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit GWQ43_RS05965 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS05980 ENOG4105CHR reductase GWQ43_RS05985 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GWQ43_RS06000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS06000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS06010 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS06015 ENOG4107QIJ Aconitate hydratase 2 GWQ43_RS06030 ENOG4105BZN citrate synthase GWQ43_RS06035 ENOG4105CR4 methylisocitrate lyase GWQ43_RS06040 ENOG4108JU7 Transcriptional regulator GWQ43_RS06060 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GWQ43_RS06065 ENOG4105FDP GntR family transcriptional regulator GWQ43_RS06070 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GWQ43_RS06085 ENOG4105E33 succinate dehydrogenase GWQ43_RS06090 ENOG41060IS Flavinator of succinate dehydrogenase GWQ43_RS06095 ENOG4105BZN citrate synthase GWQ43_RS06100 ENOG41073TP transcriptional regulator GWQ43_RS06105 ENOG4105DAA L-lactate GWQ43_RS06110 ENOG4105C6K Malic enzyme GWQ43_RS06115 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GWQ43_RS06120 ENOG4105C7S Dehydrogenase GWQ43_RS06125 ENOG4107QN2 dihydrolipoyl dehydrogenase GWQ43_RS06130 ENOG4105D6Z AFG1 family ATPase GWQ43_RS06135 ENOG4105C31 Tryptophanyl-tRNA synthetase GWQ43_RS06150 ENOG4105BZM domain protein GWQ43_RS06155 ENOG4105DVT helicase GWQ43_RS06165 ENOG4105KVH Transcriptional regulator GWQ43_RS06180 ENOG4105NDK ethanolamine utilization protein GWQ43_RS06185 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GWQ43_RS06200 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS06210 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GWQ43_RS06215 ENOG4105C34 Pseudouridine synthase GWQ43_RS06220 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GWQ43_RS06225 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GWQ43_RS06230 ENOG4105CHR reductase GWQ43_RS06235 ENOG4108NVM synthesis repressor PhaR GWQ43_RS06265 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GWQ43_RS06270 ENOG4105FE9 pseudouridine synthase GWQ43_RS06275 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GWQ43_RS06280 ENOG4105CHV Transcription elongation factor NusA GWQ43_RS06285 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GWQ43_RS06290 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GWQ43_RS06295 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GWQ43_RS06300 ENOG4105CI3 gtp-binding protein typa GWQ43_RS06305 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase GWQ43_RS06315 ENOG4106YG3 ABC transporter GWQ43_RS06320 ENOG4105DSP amino acid AbC transporter GWQ43_RS06325 ENOG4105E89 ABC transporter GWQ43_RS06330 ENOG4108URH decarboxylase GWQ43_RS06335 ENOG4105C2M dna polymerase I GWQ43_RS06340 ENOG4105EAM Na Pi-cotransporter GWQ43_RS06350 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GWQ43_RS06360 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GWQ43_RS06365 ENOG4105D0M Protease HtpX homolog GWQ43_RS06375 ENOG4105KHC sulfurtransferase GWQ43_RS06380 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GWQ43_RS06385 ENOG4105CTB Polyprenyl synthetase GWQ43_RS06395 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GWQ43_RS06400 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GWQ43_RS06410 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GWQ43_RS06420 ENOG4105CDU Replicative dna helicase GWQ43_RS06425 ENOG4105DHU Bile acid GWQ43_RS06430 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GWQ43_RS06435 ENOG4108IAB Phoh family GWQ43_RS06440 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWQ43_RS06450 ENOG4105CHM Aminotransferase GWQ43_RS06455 ENOG4105D6E homoserine dehydrogenase GWQ43_RS06465 ENOG4108MK9 spermidine N(1)-acetyltransferase GWQ43_RS06470 ENOG4105CVN desaturase GWQ43_RS06480 ENOG4105FBD synthase GWQ43_RS06485 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GWQ43_RS06490 ENOG4105CHR reductase GWQ43_RS06495 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GWQ43_RS06515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS06520 ENOG4105F38 ABC transporter, permease GWQ43_RS06525 ENOG4105D38 putrescine abc transporter GWQ43_RS06535 ENOG4105E66 phosphoriboisomerase A GWQ43_RS06540 ENOG4108UTW Plays a role in the regulation of phosphate uptake GWQ43_RS06550 ENOG4105CHH sulfate transporter GWQ43_RS06555 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GWQ43_RS06560 ENOG4108EKC n-acetylglutamate synthase GWQ43_RS06565 ENOG4105CQ7 ATP-dependent helicase GWQ43_RS06570 ENOG4105C0B DNA polymerase III (alpha subunit) GWQ43_RS06575 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GWQ43_RS06580 ENOG4107BJW polysaccharide deacetylase GWQ43_RS06585 ENOG4106WTF Glycosyl transferase, family 2 GWQ43_RS06595 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GWQ43_RS06605 ENOG4105KRS Proteinase inhibitor GWQ43_RS06620 ENOG4105BZ1 (ABC) transporter GWQ43_RS06635 ENOG4105C03 ribonuclease GWQ43_RS06670 ENOG4108KWP DNA-binding transcriptional regulator GlcC GWQ43_RS06675 ENOG4105CQB FAD linked oxidase domain protein GWQ43_RS06680 ENOG4105EU8 FAD linked oxidase domain protein GWQ43_RS06685 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GWQ43_RS06690 ENOG4108BUD transposase GWQ43_RS06735 ENOG4108Z9W Outer membrane porin GWQ43_RS06745 ENOG4106UX7 integral membrane protein GWQ43_RS06755 ENOG4105DUM transcriptional regulator, lysR family GWQ43_RS06765 ENOG4108YY7 Invasion gene expression up-regulator SirB GWQ43_RS06775 ENOG41080HT Transcriptional regulator, arsr family GWQ43_RS06800 ENOG4105CHH sulfate transporter GWQ43_RS06805 ENOG4105E6M Sulphatase-modifying factor protein GWQ43_RS06810 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GWQ43_RS06815 ENOG4105YB8 TM2 domain containing protein GWQ43_RS06820 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GWQ43_RS06825 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GWQ43_RS06830 ENOG4105K4H Nlp p60 protein GWQ43_RS06835 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) GWQ43_RS06840 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region GWQ43_RS06845 ENOG4107RD7 Flagellar Motor Protein, MotA GWQ43_RS06850 ENOG4105ER2 Ompa motb domain protein GWQ43_RS06855 ENOG4105CBS Chea signal transduction histidine kinase GWQ43_RS06860 ENOG4108V3W Chemotaxis protein, CheW GWQ43_RS06865 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS06870 ENOG4105BZU Histidine kinase GWQ43_RS06880 ENOG4108VYJ response regulator receiver protein GWQ43_RS06885 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GWQ43_RS06890 ENOG4105D00 flagellar biosynthetic protein flhB GWQ43_RS06895 ENOG4105D7B Flagellar biosynthesis protein flha GWQ43_RS06900 ENOG4105FZW flagellar biosynthesis regulator FlhF GWQ43_RS06910 ENOG4105M9M anti-sigma28 factor FlgM GWQ43_RS06920 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GWQ43_RS06925 ENOG4108ZC9 flagellar basal-body rod protein flgc GWQ43_RS06930 ENOG4105W00 Flagellar hook capping protein GWQ43_RS06935 ENOG4105BZE flagellar hook protein, FlgE GWQ43_RS06940 ENOG4108KPB Flagellar basal-body rod protein FlgF GWQ43_RS06945 ENOG4105CGA flagellar basal-body rod protein FlgG GWQ43_RS06960 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GWQ43_RS06965 ENOG4105E1Q flagellar hook-associated protein GWQ43_RS06970 ENOG4105DTJ flagellar hook-associated protein GWQ43_RS06975 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS06985 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS06995 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GWQ43_RS07000 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GWQ43_RS07010 ENOG4105CN7 Flagellar biosynthetic protein FliP GWQ43_RS07020 ENOG4105DD5 Flagellar motor switch protein GWQ43_RS07025 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWQ43_RS07030 ENOG4107ZI8 flagellar basal body-associated protein flil GWQ43_RS07045 ENOG4108JIR Flagellum-specific ATP synthase GWQ43_RS07055 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWQ43_RS07060 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GWQ43_RS07065 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GWQ43_RS07070 ENOG4105D00 flagellar biosynthetic protein flhB GWQ43_RS07085 ENOG4105MQ3 flagellar protein FliS GWQ43_RS07090 ENOG4105DTS flagellar hook-associated GWQ43_RS07095 ENOG41063QE flagellar protein FlaG GWQ43_RS07100 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWQ43_RS07105 ENOG4105I03 Flagellin GWQ43_RS07140 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GWQ43_RS07150 ENOG4105E6M Sulphatase-modifying factor protein GWQ43_RS07170 ENOG4106BRA Membrane GWQ43_RS07175 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GWQ43_RS07180 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GWQ43_RS07190 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GWQ43_RS07205 ENOG4105CY2 Citrate transporter GWQ43_RS07225 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWQ43_RS07265 ENOG4105MQ5 zona occludens toxin GWQ43_RS07280 ENOG4105YES addiction module antidote protein GWQ43_RS07285 ENOG4105VUH addiction module killer protein GWQ43_RS07290 ENOG4106FTQ Taurine ABC transporter, periplasmic GWQ43_RS07295 ENOG4108IY8 ABC, transporter GWQ43_RS07300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS07305 ENOG4105CHR reductase GWQ43_RS07310 ENOG4105ETT transcriptional Regulator, LysR family GWQ43_RS07335 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS07340 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GWQ43_RS07355 ENOG4105PE1 Receptor GWQ43_RS07360 ENOG4105CA0 peroxidase GWQ43_RS07370 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS07380 ENOG4105C85 amino acid GWQ43_RS07400 ENOG4105CC0 LysR family Transcriptional regulator GWQ43_RS07405 ENOG4105VTN Protein of unknown function (DUF1311) GWQ43_RS07410 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GWQ43_RS07450 ENOG4107S7U Sulfide dehydrogenase GWQ43_RS07475 ENOG4105VEQ Cold shock protein GWQ43_RS07480 ENOG4105DHQ Histidine kinase GWQ43_RS07485 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS07490 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GWQ43_RS07500 ENOG41090Y2 cytochrome C GWQ43_RS07505 ENOG4105NQN cytochrome C GWQ43_RS07510 ENOG4108R1E Serine threonine protein phosphatase 1 GWQ43_RS07550 ENOG4105EEQ Na H antiporter GWQ43_RS07560 ENOG4105J12 Multidrug resistance protein mdtN GWQ43_RS07565 ENOG4105EM2 membrane GWQ43_RS07570 ENOG4105C7N Xanthine uracil vitamin C permease GWQ43_RS07605 ENOG4105CBC glutamate synthase GWQ43_RS07615 ENOG4108SY4 MarR family Transcriptional regulator GWQ43_RS07625 ENOG4108I0Z Aconitate hydratase GWQ43_RS07665 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GWQ43_RS07675 ENOG4105EGS Mechanosensitive ion channel GWQ43_RS07680 ENOG4105EGS Mechanosensitive ion channel GWQ43_RS07685 ENOG4105CSH Transporter GWQ43_RS07700 ENOG4108IMY Transcriptional regulator GWQ43_RS07705 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GWQ43_RS07710 ENOG4105BZU Histidine kinase GWQ43_RS07715 ENOG4105CJW magnesium transporter GWQ43_RS07725 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GWQ43_RS07730 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GWQ43_RS07745 ENOG4108W0I acetyltransferase GWQ43_RS07755 ENOG4108K0D peptidase, M48 GWQ43_RS07760 ENOG4105F27 Major Facilitator GWQ43_RS07770 ENOG4105KRQ Addiction module toxin, Txe YoeB family GWQ43_RS07905 ENOG4105KUS lysozyme GWQ43_RS07960 ENOG4105BZU Histidine kinase GWQ43_RS07975 ENOG4108XM1 transcriptional regulator AsnC family GWQ43_RS07980 ENOG4105C28 cystathionine GWQ43_RS07990 ENOG4105M6F mutator MutT protein GWQ43_RS07995 ENOG4105WD1 Membrane GWQ43_RS08005 ENOG4105CDH Citrulline--aspartate ligase GWQ43_RS08010 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GWQ43_RS08015 ENOG4108IJ6 ABC transporter GWQ43_RS08035 ENOG4105ETE Transcriptional regulator (LacI family GWQ43_RS08045 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GWQ43_RS08055 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GWQ43_RS08060 ENOG4105C08 Histidine kinase GWQ43_RS08065 ENOG4105EEX Two component transcriptional regulator (Winged helix family GWQ43_RS08070 ENOG4105DBV ornithine carbamoyltransferase GWQ43_RS08080 ENOG4105C5I Dehydrogenase GWQ43_RS08085 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) GWQ43_RS08090 ENOG4105CJR Integral membrane protein (MviN GWQ43_RS08105 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GWQ43_RS08110 ENOG4105W49 UPF0434 protein GWQ43_RS08115 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GWQ43_RS08120 ENOG4105M8F Biopolymer transport protein exbD tolR GWQ43_RS08125 ENOG41090AP transport protein GWQ43_RS08130 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GWQ43_RS08135 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GWQ43_RS08140 ENOG4108UWD Iron-storage protein GWQ43_RS08145 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS08155 ENOG4105VEQ Cold shock protein GWQ43_RS08160 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GWQ43_RS08165 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GWQ43_RS08170 ENOG4105F1S paraquat-inducible protein a GWQ43_RS08175 ENOG4105DY2 Paraquat-inducible protein b GWQ43_RS08195 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS08200 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GWQ43_RS08205 ENOG4105C0Z ABC transporter GWQ43_RS08210 ENOG4108IV0 ABC, transporter GWQ43_RS08235 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GWQ43_RS08240 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GWQ43_RS08245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GWQ43_RS08250 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GWQ43_RS08255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GWQ43_RS08260 ENOG4105DTN riboflavin biosynthesis protein ribF GWQ43_RS08265 ENOG4108V3E phosphoribosylglycinamide formyltransferase GWQ43_RS08280 ENOG4105C4R Atp-dependent dna helicase GWQ43_RS08325 ENOG4105F9N Major Facilitator Superfamily GWQ43_RS08335 ENOG4105C5H ABC transporter GWQ43_RS08340 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GWQ43_RS08345 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GWQ43_RS08350 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GWQ43_RS08360 ENOG4105R1U AraC Family Transcriptional Regulator GWQ43_RS08420 ENOG4108Z4X TRANSCRIPTIONal GWQ43_RS08535 ENOG4105UZW Tail fiber assembly protein GWQ43_RS08595 ENOG4105EGI Transcriptional regulator GWQ43_RS08600 ENOG4105JSC dimethylmenaquinone methyltransferase GWQ43_RS08660 ENOG4108RAV Conserved protein GWQ43_RS08685 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GWQ43_RS08690 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GWQ43_RS08695 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GWQ43_RS08705 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GWQ43_RS08715 ENOG4108YYQ gCN5-related N-acetyltransferase GWQ43_RS08720 ENOG4105CGF Aromatic amino acid aminotransferase GWQ43_RS08725 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GWQ43_RS08740 ENOG4105C3J Cysteine desulfurase GWQ43_RS08745 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GWQ43_RS08750 ENOG4108Z4V iron-sulfur cluster assembly GWQ43_RS08765 ENOG4105CRK lysyL-tRNA synthetase GWQ43_RS08770 ENOG4105PDP Short chain dehydrogenase GWQ43_RS08780 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS08785 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GWQ43_RS08790 ENOG4108IPJ Membrane GWQ43_RS08795 ENOG4105C09 Bile acid GWQ43_RS08805 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GWQ43_RS08820 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GWQ43_RS08825 ENOG4105EYA deoxyribonuclease GWQ43_RS08830 ENOG4108EC8 DNA internalization-related competence protein ComEC GWQ43_RS08840 ENOG4105DB7 PHP domain protein GWQ43_RS08850 ENOG4108ETH Formylglycinamide ribotide synthetase GWQ43_RS08855 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GWQ43_RS08875 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GWQ43_RS08895 ENOG4105CNM Receptor GWQ43_RS08905 ENOG4105CNV Aldolase GWQ43_RS08915 ENOG4107XC4 flavin reductase domain protein, FMN-binding GWQ43_RS08930 ENOG4105DZ2 Transcriptional regulator GWQ43_RS08955 ENOG4105CSU acyl-Coa dehydrogenase GWQ43_RS08960 ENOG4105CKI cobalamin synthesis protein GWQ43_RS08965 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GWQ43_RS08970 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GWQ43_RS08980 ENOG4105CD3 dihydroorotase GWQ43_RS08985 ENOG41090R7 Ferric uptake GWQ43_RS08990 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GWQ43_RS09010 ENOG4105ETX regulatoR GWQ43_RS09015 ENOG4105E7U AraC family transcriptional regulator GWQ43_RS09025 ENOG4105DWF phosphomethylpyrimidine kinase GWQ43_RS09040 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) GWQ43_RS09050 ENOG4105Y49 secretion protein, HlyD family GWQ43_RS09060 ENOG41090U3 tautomerase GWQ43_RS09065 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GWQ43_RS09075 ENOG4105EA8 2-Nitropropane dioxygenase GWQ43_RS09110 ENOG4108JGH Tetr family transcriptional regulator GWQ43_RS09140 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GWQ43_RS09190 ENOG410846T CoA-transferase family III GWQ43_RS09200 ENOG4105C1G acyl-Coa dehydrogenase GWQ43_RS09230 ENOG41080HT Transcriptional regulator, arsr family GWQ43_RS09255 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GWQ43_RS09280 ENOG410626B catechol 1,2-dioxygenase GWQ43_RS09290 ENOG4107QNJ CoA-transferase subunit B GWQ43_RS09295 ENOG4105F2Z 3-oxoadipate enol-lactonase GWQ43_RS09305 ENOG4105DKK Benzoate GWQ43_RS09310 ENOG4108MR5 GWQ43_RS09315 ENOG4108MZY GWQ43_RS09325 ENOG4108IUW ABC transporter GWQ43_RS09335 ENOG4105WH1 Two component transcriptional regulator luxr family GWQ43_RS09340 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GWQ43_RS09365 ENOG4108VHT MarR family transcriptional regulator GWQ43_RS09370 ENOG4105MSY salicylate hydroxylase GWQ43_RS09375 ENOG4105CSP Major Facilitator Superfamily GWQ43_RS09385 ENOG4105DFA alanine racemase domain protein GWQ43_RS09390 ENOG4105CSW GntR family transcriptional regulator GWQ43_RS09395 ENOG4108KTG Membrane protein, drug metabolite transporter GWQ43_RS09405 ENOG4105F2V VRR-NUC domain-containing protein GWQ43_RS09420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS09435 ENOG41062D9 Histidine kinase GWQ43_RS09450 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GWQ43_RS09455 ENOG4105CPC Aldo Keto reductase GWQ43_RS09475 ENOG4108RAV Conserved protein GWQ43_RS09525 ENOG4108UT2 hemolysin iii GWQ43_RS09530 ENOG4105KWI UPF0339 protein GWQ43_RS09550 ENOG4105EAB amino acid AbC transporter GWQ43_RS09555 ENOG4105E5Q amino acid AbC transporter GWQ43_RS09560 ENOG4105DRP amino acid AbC transporter GWQ43_RS09565 ENOG4105CDA abc transporter atp-binding protein GWQ43_RS09615 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein GWQ43_RS09645 ENOG4105D2S major facilitator superfamily GWQ43_RS09650 ENOG410829K Lysine exporter protein (Lyse ygga) GWQ43_RS09660 ENOG4105ETE Transcriptional regulator (LacI family GWQ43_RS09670 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GWQ43_RS09700 ENOG4107QX8 SPFH domain, Band 7 family protein GWQ43_RS09705 ENOG4105G5H Membrane GWQ43_RS09710 ENOG4108D32 Methyltransferase GWQ43_RS09720 ENOG4105UCG Domain of unknown function (DUF333) GWQ43_RS09730 ENOG4108MGF sugar kinase GWQ43_RS09750 ENOG4105C22 threonyL-tRNA synthetase GWQ43_RS09755 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GWQ43_RS09770 ENOG41080Z8 PHOSPHOCARRIER protein GWQ43_RS09775 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GWQ43_RS09800 ENOG4105C0P Mg chelatase subunit ChlI GWQ43_RS09815 ENOG4105VJV 50s ribosomal protein L35 GWQ43_RS09820 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GWQ43_RS09825 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GWQ43_RS09830 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GWQ43_RS09845 ENOG4105ED9 Protein of unknown function (DUF455) GWQ43_RS09855 ENOG4108JJ7 ABC transporter GWQ43_RS09860 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GWQ43_RS09870 ENOG4105C3K feS assembly ATPase SufC GWQ43_RS09875 ENOG4105JRK feS assembly protein SufD GWQ43_RS09880 ENOG4105C9B Cysteine desulfurase GWQ43_RS09885 ENOG4108UNV SUF system FeS assembly protein, NifU family GWQ43_RS09890 ENOG4105VG1 fes assembly suf system protein GWQ43_RS09910 ENOG4105DFG type I secretion outer membrane protein GWQ43_RS09935 ENOG4107QZV Type I secretion membrane fusion protein GWQ43_RS09950 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GWQ43_RS09965 ENOG4105HX0 Transcriptional regulator GWQ43_RS09990 ENOG4107RCH Diaminopropionate ammonia-lyase GWQ43_RS09995 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GWQ43_RS10015 ENOG4108JQ6 ABC transporter GWQ43_RS10025 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GWQ43_RS10070 ENOG4105CB2 alcohol dehydrogenase GWQ43_RS10075 ENOG41075H3 AraC family transcriptional regulator GWQ43_RS10080 ENOG4105BZC d-serine deaminase GWQ43_RS10085 ENOG4105NQN cytochrome C GWQ43_RS10095 ENOG4105FC8 fad dependent oxidoreductase GWQ43_RS10100 ENOG4108K88 Membrane GWQ43_RS10110 ENOG4105E6M Sulphatase-modifying factor protein GWQ43_RS10125 ENOG4105CZN Potassium uptake protein GWQ43_RS10135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GWQ43_RS10145 ENOG4105KTH gatB Yqey GWQ43_RS10150 ENOG4105C0B DNA polymerase III (alpha subunit) GWQ43_RS10190 ENOG4105DUM transcriptional regulator, lysR family GWQ43_RS10195 ENOG41061WM D-Alanyl-D-Alanine GWQ43_RS10205 ENOG4107R0U MotA TolQ exbB proton channel GWQ43_RS10210 ENOG4105ER2 Ompa motb domain protein GWQ43_RS10220 ENOG4105FGE Short-chain dehydrogenase reductase Sdr GWQ43_RS10230 ENOG4105EMU Dehydrogenase GWQ43_RS10240 ENOG4108R6K riboflavin synthase, subunit alpha GWQ43_RS10250 ENOG4108IJ0 Aspartate ammonia-lyase GWQ43_RS10255 ENOG4105CK2 sodium dicarboxylate symporter GWQ43_RS10265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWQ43_RS10270 ENOG4106P55 Transcriptional regulator GWQ43_RS10275 ENOG4107EFR Flavocytochrome c GWQ43_RS10280 ENOG41079YP Citrate utilization protein b GWQ43_RS10290 ENOG4105DB1 molybdopterin oxidoreductase GWQ43_RS10295 ENOG4106WHD Tetrathionate reductase GWQ43_RS10300 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GWQ43_RS10370 ENOG4105BZU Histidine kinase GWQ43_RS10400 ENOG4108VSE mercuric transport protein GWQ43_RS10405 ENOG4105W1Y Transcriptional regulator GWQ43_RS10415 ENOG4107RNH Outer membrane receptor FepA GWQ43_RS10430 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GWQ43_RS10435 ENOG4105C2W permease GWQ43_RS10440 ENOG4107Y70 Heat shock protein GWQ43_RS10485 ENOG4105E09 nadh pyrophosphatase GWQ43_RS10490 ENOG4105DSJ YicC domain protein GWQ43_RS10495 ENOG4107RFY SbcCD D subunit GWQ43_RS10505 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GWQ43_RS10510 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GWQ43_RS10515 ENOG4105CSA Coproporphyrinogen iii oxidase GWQ43_RS10525 ENOG4107YB6 acetyltransferase, (GNAT) family GWQ43_RS10545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS10550 ENOG4107Z6A sulfate abc transporter permease GWQ43_RS10560 ENOG4105DP0 ferredoxin-NADP reductase GWQ43_RS10565 ENOG4105KME endoribonuclease L-psp GWQ43_RS10570 ENOG4105CB5 ATP-dependent DNA helicase recG GWQ43_RS10575 ENOG4105C5Q Transcriptional regulator GWQ43_RS10585 ENOG4105CP9 extracellular ligand-binding receptor GWQ43_RS10590 ENOG4108IJ9 (ABC) transporter GWQ43_RS10605 ENOG4105BZ7 extracellular solute-binding protein family 1 GWQ43_RS10610 ENOG4105II7 pyrroline-5-carboxylate reductase GWQ43_RS10615 ENOG4105CP9 extracellular ligand-binding receptor GWQ43_RS10620 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS10625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GWQ43_RS10630 ENOG4105C0Z ABC transporter GWQ43_RS10635 ENOG4108IV0 ABC, transporter GWQ43_RS10640 ENOG4108K3A Glutathione S-transferase GWQ43_RS10650 ENOG4105C5I Dehydrogenase GWQ43_RS10655 ENOG4105CHR reductase GWQ43_RS10660 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GWQ43_RS10665 ENOG4105C9Q fumarate hydratase class II GWQ43_RS10670 ENOG4105D8V Glucose sorbosone dehydrogenase GWQ43_RS10675 ENOG4108I0C methyltransferase GWQ43_RS10680 ENOG4107YZX Universal stress protein GWQ43_RS10685 ENOG4105W2Z cytochrome C, class I GWQ43_RS10690 ENOG4105R1U AraC Family Transcriptional Regulator GWQ43_RS10705 ENOG4105C26 Dehydrogenase GWQ43_RS10710 ENOG4107SCK Monooxygenase GWQ43_RS10715 ENOG4105DJ2 Major Facilitator Superfamily GWQ43_RS10725 ENOG4105EJC lysr family transcriptional regulator GWQ43_RS10740 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GWQ43_RS10755 ENOG4105CR8 Transcriptional regulator GWQ43_RS10760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWQ43_RS10775 ENOG4105E3B Multicopper oxidase GWQ43_RS10790 ENOG4105CSR polyphosphate kinase 2 GWQ43_RS10795 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GWQ43_RS10825 ENOG4105CPW cytochrome b561 GWQ43_RS10835 ENOG4108YYC ycei family GWQ43_RS10840 ENOG4105K89 arsenate reductase GWQ43_RS10845 ENOG4105CYM Glutathione S-transferase GWQ43_RS10855 ENOG4108YYH Nadph-dependent fmn reductase GWQ43_RS10865 ENOG4105F8V Hydrolase, tatD family GWQ43_RS10870 ENOG4107QRG dna polymerase iii GWQ43_RS10880 ENOG4105HHA aminodeoxychorismate lyase GWQ43_RS10885 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GWQ43_RS10890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GWQ43_RS10900 ENOG4105C1G acyl-Coa dehydrogenase GWQ43_RS10905 ENOG4105VDB UPF0125 protein GWQ43_RS10910 ENOG4108Z1B Cyclase dehydrase GWQ43_RS10915 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GWQ43_RS10920 ENOG4105CEP NADH dehydrogenase GWQ43_RS10925 ENOG410630P Transcriptional regulator GWQ43_RS10930 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GWQ43_RS10950 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GWQ43_RS10955 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GWQ43_RS10965 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GWQ43_RS10970 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GWQ43_RS10975 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GWQ43_RS10980 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GWQ43_RS10985 ENOG4105DZP Membrane-associated zinc metalloprotease GWQ43_RS10990 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GWQ43_RS10995 ENOG4105KNE Phosphatidate cytidylyltransferase GWQ43_RS11000 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GWQ43_RS11005 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GWQ43_RS11010 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GWQ43_RS11015 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GWQ43_RS11020 ENOG4105CE9 30S ribosomal protein S2 GWQ43_RS11025 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GWQ43_RS11030 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GWQ43_RS11045 ENOG4107S1E Beta-lactamase GWQ43_RS11050 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GWQ43_RS11055 ENOG4105E96 Colicin v production protein GWQ43_RS11065 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GWQ43_RS11070 ENOG4107QN2 dihydrolipoyl dehydrogenase GWQ43_RS11075 ENOG4107QSN dihydrolipoamide acetyltransferase GWQ43_RS11080 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GWQ43_RS11085 ENOG4105BZU Histidine kinase GWQ43_RS11095 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GWQ43_RS11100 ENOG4105DGW oligopeptidase A GWQ43_RS11115 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWQ43_RS11120 ENOG4105YVS arsR family transcriptional regulator GWQ43_RS11130 ENOG4108Z6Z Transcriptional regulator GWQ43_RS11135 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS11140 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GWQ43_RS11145 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit GWQ43_RS11150 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GWQ43_RS11155 ENOG4105CHR reductase GWQ43_RS11160 ENOG4105CHR reductase GWQ43_RS11200 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GWQ43_RS11210 ENOG4105BZS acriflavin resistance protein GWQ43_RS11215 ENOG4105C1P efflux transporter, rnd family, mfp subunit GWQ43_RS11220 ENOG4105D5T phosphonate abc transporter GWQ43_RS11240 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS11245 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS11255 ENOG4105CR4 methylisocitrate lyase GWQ43_RS11265 ENOG4105EMY transcriptional regulator GWQ43_RS11270 ENOG4105CXN decarboxylase GWQ43_RS11290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GWQ43_RS11295 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GWQ43_RS11300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GWQ43_RS11310 ENOG4108UMN azlc family GWQ43_RS11315 ENOG4105DR5 peptidase GWQ43_RS11320 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GWQ43_RS11325 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GWQ43_RS11330 ENOG4105D6S protein involved in catabolism of external DNA GWQ43_RS11335 ENOG4105FE9 pseudouridine synthase GWQ43_RS11340 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GWQ43_RS11345 ENOG4105DXI Major Facilitator superfamily GWQ43_RS11350 ENOG4105CV8 reductase GWQ43_RS11355 ENOG4108YZA Nitrogen regulatory protein pii GWQ43_RS11360 ENOG4105CUY Mechanosensitive ion channel GWQ43_RS11365 ENOG4105CH7 arginosuccinase GWQ43_RS11385 ENOG4105CJP fad dependent oxidoreductase GWQ43_RS11395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GWQ43_RS11400 ENOG4108K5P (LipO)protein GWQ43_RS11405 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GWQ43_RS11410 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GWQ43_RS11415 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GWQ43_RS11420 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GWQ43_RS11425 ENOG4105C7N Xanthine uracil vitamin C permease GWQ43_RS11430 ENOG41080RH Thioredoxin GWQ43_RS11450 ENOG4105C5H ABC transporter GWQ43_RS11455 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GWQ43_RS11460 ENOG4108Z6B deaminase GWQ43_RS11465 ENOG4105DA5 (ABC) transporter GWQ43_RS11470 ENOG4105E3A (ABC) transporter GWQ43_RS11475 ENOG4105C8Q Methyl-accepting chemotaxis GWQ43_RS11480 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS11485 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GWQ43_RS11490 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit GWQ43_RS11495 ENOG4105CJP fad dependent oxidoreductase GWQ43_RS11505 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GWQ43_RS11525 ENOG4108FUF Transcriptional regulator, IclR family GWQ43_RS11530 ENOG4108E94 phosphate acetyltransferase GWQ43_RS11535 ENOG4105P69 integral membrane protein GWQ43_RS11545 ENOG4108VPT UPF0234 protein GWQ43_RS11550 ENOG4105CEY Amp-dependent synthetase and ligase GWQ43_RS11555 ENOG4107Z6W Protein CrcB homolog GWQ43_RS11560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GWQ43_RS11570 ENOG4105DHU Bile acid GWQ43_RS11575 ENOG4107ZT5 Thiol disulfide interchange protein GWQ43_RS11580 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GWQ43_RS11585 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS11595 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GWQ43_RS11605 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GWQ43_RS11630 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GWQ43_RS11640 ENOG4108ZXC Two component transcriptional regulator, luxr family GWQ43_RS11655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GWQ43_RS11660 ENOG4105CNG UPF0061 protein GWQ43_RS11670 ENOG4107S2Z UPF0761 membrane protein GWQ43_RS11680 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GWQ43_RS11745 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS11750 ENOG4108SF5 RNA Polymerase GWQ43_RS11765 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS11780 ENOG4105F0N pyrophosphate phospho-hydrolase GWQ43_RS11790 ENOG4105ECF c-methyltransferase GWQ43_RS11800 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GWQ43_RS11805 ENOG4108ZCF integral membrane protein GWQ43_RS11810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GWQ43_RS11815 ENOG4105CMV Succinyl-CoA synthetase subunit beta GWQ43_RS11830 ENOG4105DZ2 Transcriptional regulator GWQ43_RS11835 ENOG4108004 Modulates RecA activity (By similarity) GWQ43_RS11840 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GWQ43_RS11855 ENOG4105CSH Transporter GWQ43_RS11870 ENOG4105CEY Amp-dependent synthetase and ligase GWQ43_RS11875 ENOG4105E9F Enoyl-CoA hydratase GWQ43_RS11880 ENOG41062QD Membrane GWQ43_RS11885 ENOG4107QN1 sodium solute GWQ43_RS11890 ENOG4105C26 Dehydrogenase GWQ43_RS11895 ENOG4105CXT aspartate transcarbamylase GWQ43_RS11910 ENOG4105BZ4 penicillin-binding protein GWQ43_RS11915 ENOG4107S52 alpha-2-macroglobulin domain protein GWQ43_RS11925 ENOG4105EA8 2-Nitropropane dioxygenase GWQ43_RS11930 ENOG4105D4P Coproporphyrinogen iii oxidase GWQ43_RS11935 ENOG4105D65 subunit l GWQ43_RS11940 ENOG4108ZE9 Monovalent cation H antiporter subunit C GWQ43_RS11945 ENOG4107R4Z monovalent cation h antiporter subunit d GWQ43_RS11955 ENOG4105W4C monovalent cation H antiporter subunit F GWQ43_RS11970 ENOG4105CSH Transporter GWQ43_RS11995 ENOG4105DFH Transport of potassium into the cell (By similarity) GWQ43_RS12000 ENOG4105DHQ Histidine kinase GWQ43_RS12005 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS12025 ENOG4108IJ6 ABC transporter GWQ43_RS12030 ENOG4105ECW sulfate abc transporter GWQ43_RS12035 ENOG4108I5D sulfate abc transporter GWQ43_RS12040 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GWQ43_RS12055 ENOG4105VEQ Cold shock protein GWQ43_RS12065 ENOG4105K70 DNA-binding protein GWQ43_RS12070 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GWQ43_RS12075 ENOG4105Y7H Cytochrome GWQ43_RS12080 ENOG4106P6N cytochrome d1 heme region GWQ43_RS12085 ENOG4108UMR transcriptional regulator AsnC family GWQ43_RS12090 ENOG4108ZGY Transcriptional regulator (AsnC family) GWQ43_RS12095 ENOG4108UMR transcriptional regulator AsnC family GWQ43_RS12105 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GWQ43_RS12120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS12125 ENOG4105C28 cystathionine GWQ43_RS12130 ENOG4105C2N RNA methyltransferase TrmH family group 3 GWQ43_RS12135 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GWQ43_RS12150 ENOG41060NJ transcriptional regulator GWQ43_RS12155 ENOG4105E5Q amino acid AbC transporter GWQ43_RS12160 ENOG4105E5Q amino acid AbC transporter GWQ43_RS12165 ENOG4105CDA abc transporter atp-binding protein GWQ43_RS12180 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GWQ43_RS12200 ENOG4105Q26 Siderophore-interacting protein GWQ43_RS12225 ENOG4105W5Z GWQ43_RS12230 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GWQ43_RS12245 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS12255 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GWQ43_RS12260 ENOG4105C4Y ABC transporter GWQ43_RS12285 ENOG4108Z7F N-acetyltransferase GWQ43_RS12295 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GWQ43_RS12300 ENOG4105VRT cytoplasmic protein GWQ43_RS12305 ENOG4105CYM Glutathione S-transferase GWQ43_RS12310 ENOG4105EUB pirin domain protein GWQ43_RS12325 ENOG4105F27 Major Facilitator GWQ43_RS12330 ENOG4105DJ2 Major Facilitator Superfamily GWQ43_RS12335 ENOG4105R1U AraC Family Transcriptional Regulator GWQ43_RS12340 ENOG4105DKK Benzoate GWQ43_RS12365 ENOG4105C7W Xanthine dehydrogenase GWQ43_RS12375 ENOG4107QUY Guanine deaminase GWQ43_RS12385 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS12395 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWQ43_RS12400 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GWQ43_RS12405 ENOG4105VCC 30S ribosomal protein S21 GWQ43_RS12410 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GWQ43_RS12415 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GWQ43_RS12425 ENOG4105EPW hflc protein GWQ43_RS12430 ENOG4107QJR hflk protein GWQ43_RS12435 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GWQ43_RS12440 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GWQ43_RS12445 ENOG4105CIH Imidazole acetol-phosphate transaminase GWQ43_RS12450 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GWQ43_RS12455 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GWQ43_RS12460 ENOG4105N21 Membrane GWQ43_RS12465 ENOG4105CUT histidyl-tRNA synthetase GWQ43_RS12480 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GWQ43_RS12485 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GWQ43_RS12500 ENOG4108PCN EamA-like transporter family GWQ43_RS12505 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GWQ43_RS12515 ENOG4105K5M 30s ribosomal protein S16 GWQ43_RS12520 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GWQ43_RS12525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GWQ43_RS12570 ENOG4105BZ7 extracellular solute-binding protein family 1 GWQ43_RS12575 ENOG4105MWK D-amino acid dehydrogenase, small subunit GWQ43_RS12585 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWQ43_RS12590 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWQ43_RS12595 ENOG4105K63 Thioredoxin GWQ43_RS12600 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GWQ43_RS12605 ENOG4105D82 Glutamate dehydrogenase GWQ43_RS12630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWQ43_RS12635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GWQ43_RS12665 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GWQ43_RS12670 ENOG4105WPN DNA integration recombination invertion protein GWQ43_RS12675 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GWQ43_RS12680 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GWQ43_RS12695 ENOG4105C58 cytochrome c oxidase accessory protein ccog GWQ43_RS12715 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GWQ43_RS12725 ENOG4105C59 p-type ATPase GWQ43_RS12735 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GWQ43_RS12755 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GWQ43_RS12760 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GWQ43_RS12770 ENOG4108ZJI phenylacetic acid degradation protein GWQ43_RS12775 ENOG4108UKI Enoyl-CoA hydratase GWQ43_RS12780 ENOG4105C26 Dehydrogenase GWQ43_RS12785 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GWQ43_RS12790 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GWQ43_RS12795 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GWQ43_RS12800 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GWQ43_RS12805 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GWQ43_RS12810 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GWQ43_RS12815 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GWQ43_RS12820 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GWQ43_RS12830 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GWQ43_RS12850 ENOG4105D3R alkyl hydroperoxide reductase GWQ43_RS12855 ENOG4105CSU acyl-Coa dehydrogenase GWQ43_RS12860 ENOG4105C10 Electron transfer flavoprotein GWQ43_RS12865 ENOG4105BZJ Electron transfer flavoprotein GWQ43_RS12875 ENOG4105CVE Lytic murein transglycosylase GWQ43_RS12880 ENOG4105C6T cysteine synthase GWQ43_RS12885 ENOG4105KQC Competence protein GWQ43_RS12890 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GWQ43_RS12895 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GWQ43_RS12900 ENOG4105CFV Tetratricopeptide repeat protein GWQ43_RS12915 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GWQ43_RS12920 ENOG4105CAT Cytidine monophosphate kinase GWQ43_RS12925 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GWQ43_RS12930 ENOG4105EVN Prephenate dehydrogenase GWQ43_RS12935 ENOG4105CQC Prephenate dehydratase GWQ43_RS12940 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GWQ43_RS12945 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWQ43_RS12950 ENOG4105UYK outer membrane protein a GWQ43_RS12955 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GWQ43_RS12960 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GWQ43_RS12965 ENOG4105DUM transcriptional regulator, lysR family GWQ43_RS12975 ENOG4108Z4U Ferredoxin GWQ43_RS13005 ENOG4105F1N DNA alkylation repair GWQ43_RS13015 ENOG4105CHM Aminotransferase GWQ43_RS13025 ENOG4108UQ8 endoribonuclease L-psp GWQ43_RS13030 ENOG4108IG5 Transcriptional regulator GWQ43_RS13040 ENOG4105C5H ABC transporter GWQ43_RS13090 ENOG4105CYM Glutathione S-transferase GWQ43_RS13130 ENOG4105CVR type I restriction-modification system GWQ43_RS13135 ENOG4105EKX Restriction modification system DNA (Specificity GWQ43_RS13140 ENOG4105DZR Type I site-specific deoxyribonuclease GWQ43_RS13150 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GWQ43_RS13155 ENOG410829K Lysine exporter protein (Lyse ygga) GWQ43_RS13175 ENOG4107QN1 sodium solute GWQ43_RS13185 ENOG4105BZU Histidine kinase GWQ43_RS13190 ENOG4107RIQ Sulfate adenylate transferase GWQ43_RS13195 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GWQ43_RS13210 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GWQ43_RS13225 ENOG4105EXG Transcriptional regulator GWQ43_RS13230 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GWQ43_RS13235 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GWQ43_RS13250 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GWQ43_RS13255 ENOG4105CGZ zinc metallopeptidase GWQ43_RS13270 ENOG4105E2B Taurine dioxygenase GWQ43_RS13275 ENOG4105K56 Transcriptional regulator GWQ43_RS13280 ENOG4108YZA Nitrogen regulatory protein pii GWQ43_RS13285 ENOG4105BZU Histidine kinase GWQ43_RS13290 ENOG4105T86 cytochrome C GWQ43_RS13295 ENOG4107QTF adenylosuccinate lyase GWQ43_RS13300 ENOG4108U78 Glutathione S-transferase GWQ43_RS13315 ENOG4105HF0 Membrane GWQ43_RS13320 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GWQ43_RS13325 ENOG4105CQB FAD linked oxidase domain protein GWQ43_RS13330 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GWQ43_RS13335 ENOG4105VCD cytoplasmic protein GWQ43_RS13340 ENOG4105D22 carbon starvation protein GWQ43_RS13365 ENOG4105C7K acetolactate synthase GWQ43_RS13370 ENOG4105C26 Dehydrogenase GWQ43_RS13375 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) GWQ43_RS13380 ENOG4105CHR reductase GWQ43_RS13390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS13395 ENOG4105D7T ABC transporter GWQ43_RS13410 ENOG4108Z9W Outer membrane porin GWQ43_RS13425 ENOG4105EV8 ectoine hydroxylase GWQ43_RS13430 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GWQ43_RS13440 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GWQ43_RS13445 ENOG41090MY MarR family Transcriptional regulator GWQ43_RS13455 ENOG4105D1U peptidase U62 modulator of DNA gyrase GWQ43_RS13460 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS GWQ43_RS13470 ENOG4105CD8 aminopeptidase N GWQ43_RS13475 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GWQ43_RS13480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GWQ43_RS13490 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GWQ43_RS13500 ENOG4105D7A ATP-binding protein GWQ43_RS13505 ENOG4105CDY transcriptional regulatory protein GWQ43_RS13510 ENOG4105C12 Phosphoribosylglycinamide synthetase GWQ43_RS13520 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GWQ43_RS13525 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GWQ43_RS13530 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GWQ43_RS13535 ENOG4108Z03 MAF-like protein GWQ43_RS13540 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GWQ43_RS13555 ENOG4108ZJT translation initiation factor, Sui1 GWQ43_RS13565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GWQ43_RS13570 ENOG4108RXX maleylacetoacetate isomerase GWQ43_RS13575 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GWQ43_RS13580 ENOG4108YZY peptidylprolyl cis-trans isomerase GWQ43_RS13585 ENOG4105W5Q DNA repair protein (RadC GWQ43_RS13590 ENOG4106KNT transcriptional regulator GWQ43_RS13595 ENOG4105C54 Major Facilitator superfamily GWQ43_RS13605 ENOG4105CSP Major Facilitator Superfamily GWQ43_RS13620 ENOG4107QI1 Mate efflux family protein GWQ43_RS13625 ENOG4108IJ7 Glycine betaine GWQ43_RS13630 ENOG4108HQS Glycine betaine GWQ43_RS13640 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GWQ43_RS13645 ENOG4105C2C drug resistance transporter, Bcr CflA GWQ43_RS13650 ENOG4105KDC 50s ribosomal protein l28 GWQ43_RS13655 ENOG4105W0E 50S ribosomal protein L33 GWQ43_RS13660 ENOG4105C8T Leucyl-tRNA synthetase GWQ43_RS13670 ENOG4105DJF DNA polymerase III, delta' subunit GWQ43_RS13675 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GWQ43_RS13695 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GWQ43_RS13705 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GWQ43_RS13710 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GWQ43_RS13735 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GWQ43_RS13740 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GWQ43_RS13745 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GWQ43_RS13770 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GWQ43_RS13775 ENOG4108594 Permease of the drug metabolite transporter GWQ43_RS13780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GWQ43_RS13790 ENOG4105K4H Nlp p60 protein GWQ43_RS13800 ENOG4107R11 Transcriptional regulator GWQ43_RS13805 ENOG4105C26 Dehydrogenase GWQ43_RS13810 ENOG4105SKE transcriptional Regulator LysR family GWQ43_RS13820 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GWQ43_RS13835 ENOG4105D7W serine acetyltransferase GWQ43_RS13850 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GWQ43_RS13855 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GWQ43_RS13860 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GWQ43_RS13865 ENOG4105C3F Signal peptidase i GWQ43_RS13875 ENOG4105C0H protease GWQ43_RS13890 ENOG4105EMN RNA polymerase sigma factor GWQ43_RS13895 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GWQ43_RS13900 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GWQ43_RS13905 ENOG4105CHR reductase GWQ43_RS13910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GWQ43_RS13915 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GWQ43_RS13925 ENOG4105VGS 50s ribosomal protein l32 GWQ43_RS13930 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GWQ43_RS13935 ENOG4108UHJ MAF-like protein GWQ43_RS13940 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GWQ43_RS13945 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GWQ43_RS13950 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) GWQ43_RS13955 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GWQ43_RS13960 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GWQ43_RS13965 ENOG4105EI2 Pseudouridine synthase GWQ43_RS13970 ENOG4105C03 ribonuclease GWQ43_RS13975 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GWQ43_RS13980 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GWQ43_RS13985 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GWQ43_RS13990 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GWQ43_RS14000 ENOG4107RH7 Nicotinate phosphoribosyltransferase GWQ43_RS14005 ENOG4108Z4U Ferredoxin GWQ43_RS14015 ENOG4108R3D Electron transport complex GWQ43_RS14020 ENOG4105CSM endonuclease III GWQ43_RS14025 ENOG4108JJ8 (ABC) transporter GWQ43_RS14030 ENOG4105EIF outer membrane protein W GWQ43_RS14035 ENOG4108IV0 ABC, transporter GWQ43_RS14040 ENOG4105C0Z ABC transporter GWQ43_RS14055 ENOG4105E0X reductase GWQ43_RS14060 ENOG4107835 probably involved in intracellular septation (By similarity) GWQ43_RS14070 ENOG4107TF3 peptidylprolyl cis-trans isomerase GWQ43_RS14075 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GWQ43_RS14085 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GWQ43_RS14095 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GWQ43_RS14100 ENOG41072GX Peptidase M22 Glycoprotease GWQ43_RS14110 ENOG4105E0F Histidine kinase GWQ43_RS14115 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GWQ43_RS14120 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GWQ43_RS14125 ENOG4108JA2 transcriptioN-repair coupling factor GWQ43_RS14130 ENOG4105EAC phosphoserine phosphatase GWQ43_RS14145 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWQ43_RS14150 ENOG4105C8S subunit m GWQ43_RS14160 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWQ43_RS14165 ENOG4105DF2 NADH dehydrogenase subunit j GWQ43_RS14170 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWQ43_RS14175 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GWQ43_RS14180 ENOG4108IEH NADH dehydrogenase subunit g GWQ43_RS14195 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWQ43_RS14200 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GWQ43_RS14205 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GWQ43_RS14210 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GWQ43_RS14215 ENOG4108Z9W Outer membrane porin GWQ43_RS14225 ENOG4107EJC Preprotein translocase subunit SecG GWQ43_RS14230 ENOG4105CP7 Triose-phosphate isomerase GWQ43_RS14235 ENOG4105CB2 alcohol dehydrogenase GWQ43_RS14255 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GWQ43_RS14260 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GWQ43_RS14265 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GWQ43_RS14270 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GWQ43_RS14275 ENOG4108ZP8 Acetolactate synthase small subunit GWQ43_RS14280 ENOG4105C7K acetolactate synthase GWQ43_RS14290 ENOG4105D1Q UPF0246 protein GWQ43_RS14315 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GWQ43_RS14320 ENOG4105D1H recombination factor protein RarA GWQ43_RS14325 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GWQ43_RS14330 ENOG4105CNU cell division protein FtsK GWQ43_RS14335 ENOG4105C3M thioredoxin reductase GWQ43_RS14345 ENOG4105WAP TPR repeat-containing protein GWQ43_RS14375 ENOG4105EBR Carboxylesterase GWQ43_RS14380 ENOG4108KC1 acyl-Coa dehydrogenase GWQ43_RS14395 ENOG4105C39 capsular polysaccharide phosphotransferase GWQ43_RS14415 ENOG4106RE7 Cytochrome GWQ43_RS14420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GWQ43_RS14440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWQ43_RS14545 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GWQ43_RS14550 ENOG4105CFG Acts as a chaperone (By similarity) GWQ43_RS14555 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GWQ43_RS14560 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GWQ43_RS14565 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GWQ43_RS14575 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GWQ43_RS14580 ENOG41090R7 Ferric uptake GWQ43_RS14585 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GWQ43_RS14590 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GWQ43_RS14615 ENOG41079KZ Major Facilitator Superfamily GWQ43_RS14620 ENOG4105CK2 sodium dicarboxylate symporter GWQ43_RS14630 ENOG4105D4A Cell wall formation (By similarity) GWQ43_RS14665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GWQ43_RS14705 ENOG4107QF7 multi-drug GWQ43_RS14720 ENOG4105CNM Receptor GWQ43_RS14725 ENOG4105C2C drug resistance transporter, Bcr CflA GWQ43_RS14735 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GWQ43_RS14740 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GWQ43_RS14745 ENOG4108MG3 formate dehydrogenase GWQ43_RS14750 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) GWQ43_RS14755 ENOG4105NIV Esterase GWQ43_RS14775 ENOG4105C0A alcohol dehydrogenase GWQ43_RS14780 ENOG4108IV0 ABC, transporter GWQ43_RS14785 ENOG4108IUZ ABC transporter GWQ43_RS14795 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS14805 ENOG4105C26 Dehydrogenase GWQ43_RS14810 ENOG4108FUF Transcriptional regulator, IclR family GWQ43_RS14815 ENOG4105C1J atp-dependent rna helicase GWQ43_RS14820 ENOG4105VUH addiction module killer protein GWQ43_RS14825 ENOG4105YES addiction module antidote protein GWQ43_RS14830 ENOG4108W5M transcriptional regulator GWQ43_RS14835 ENOG4105FUY alpha subunit GWQ43_RS14840 ENOG4108SBK dioxygenase, subunit beta GWQ43_RS14855 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase GWQ43_RS14865 ENOG4107UB2 Alpha beta hydrolase fold GWQ43_RS14875 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) GWQ43_RS14880 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GWQ43_RS14885 ENOG4108SC4 )-transporter GWQ43_RS14905 ENOG4105GQR Chaperone GWQ43_RS14915 ENOG4105BZU Histidine kinase GWQ43_RS14920 ENOG4105BZU Histidine kinase GWQ43_RS14925 ENOG41068CG regulatoR GWQ43_RS14940 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS14945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS14950 ENOG4105DXI Major Facilitator superfamily GWQ43_RS14980 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS14985 ENOG4105CHR reductase GWQ43_RS14995 ENOG4105CMI transporter GWQ43_RS15000 ENOG4105CJ1 ABC, transporter GWQ43_RS15005 ENOG4105D0S secretion protein (HlyD GWQ43_RS15015 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GWQ43_RS15025 ENOG4105EX9 Membrane GWQ43_RS15030 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GWQ43_RS15035 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GWQ43_RS15050 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GWQ43_RS15065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GWQ43_RS15080 ENOG4108Z4X TRANSCRIPTIONal GWQ43_RS15090 ENOG4105BZS acriflavin resistance protein GWQ43_RS15110 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein GWQ43_RS15115 ENOG4105IW1 AmiS UreI transporter GWQ43_RS15135 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GWQ43_RS15140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS15150 ENOG4105EVZ LysR family transcriptional regulator GWQ43_RS15155 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GWQ43_RS15160 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GWQ43_RS15175 ENOG4105HSS phospholipase C GWQ43_RS15205 ENOG4108C33 Resolvase GWQ43_RS15210 ENOG4105D7Q type ii secretion system GWQ43_RS15215 ENOG4107QHF type ii secretion system protein e GWQ43_RS15220 ENOG4105GVR general secretion pathway protein D GWQ43_RS15260 ENOG4108VAU general secretion pathway protein G GWQ43_RS15270 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GWQ43_RS15285 ENOG4108IJ0 Aspartate ammonia-lyase GWQ43_RS15290 ENOG41082F9 transcriptional regulator GWQ43_RS15305 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GWQ43_RS15310 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GWQ43_RS15325 ENOG41069M3 Transcriptional regulator GWQ43_RS15345 ENOG4105C1J atp-dependent rna helicase GWQ43_RS15365 ENOG4105DNZ Alpha Beta Hydrolase GWQ43_RS15370 ENOG4105ERG peptidase m48, ste24p GWQ43_RS15390 ENOG4105D0A hydroxylase GWQ43_RS15395 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GWQ43_RS15400 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GWQ43_RS15410 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GWQ43_RS15415 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GWQ43_RS15425 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GWQ43_RS15435 ENOG4105EKE dihydroorotase GWQ43_RS15445 ENOG4105CVP deoxyribo-dipyrimidine photolyase GWQ43_RS15485 ENOG4105KHC sulfurtransferase GWQ43_RS15490 ENOG41066VF YeeE YedE family protein GWQ43_RS15500 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GWQ43_RS15505 ENOG4105W2Z cytochrome C, class I GWQ43_RS15545 ENOG4105D38 putrescine abc transporter GWQ43_RS15550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWQ43_RS15555 ENOG4107QKW extracellular solute-binding protein family 1 GWQ43_RS15560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GWQ43_RS15575 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GWQ43_RS15580 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GWQ43_RS15585 ENOG4107YD3 Thioesterase GWQ43_RS15590 ENOG4105E02 MotA TolQ exbB proton channel GWQ43_RS15595 ENOG4105M8F Biopolymer transport protein exbD tolR GWQ43_RS15605 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GWQ43_RS15610 ENOG4105KCK Peptidoglycan-associated lipoprotein GWQ43_RS15620 ENOG4108J2P Alpha beta hydrolase fold GWQ43_RS15650 ENOG4105UIB (ABC) transporter GWQ43_RS15655 ENOG4105C2J ABC transporter GWQ43_RS15670 ENOG4108NIW Leucine export protein LeuE GWQ43_RS15675 ENOG4105CYC Transferase GWQ43_RS15680 ENOG4105CMU LysR family (Transcriptional regulator GWQ43_RS15685 ENOG4108JU3 Alkyl hydroperoxide reductase GWQ43_RS15700 ENOG4105T38 integral membrane protein GWQ43_RS15735 ENOG4105CC0 LysR family Transcriptional regulator GWQ43_RS15740 ENOG4105C2I pirin domain protein GWQ43_RS15745 ENOG4105BZU Histidine kinase GWQ43_RS15760 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS15765 ENOG4108SF5 RNA Polymerase GWQ43_RS15775 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GWQ43_RS15785 ENOG41080IJ Diacylglycerol kinase GWQ43_RS15790 ENOG4105SKN orotidine 5''-phosphate decarboxylase GWQ43_RS15805 ENOG4107HP6 Transcriptional regulator GWQ43_RS15815 ENOG4108ZAI phosphatidylglycerophosphatase a GWQ43_RS15820 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GWQ43_RS15825 ENOG4107YIM Involved in the transcription termination process (By similarity) GWQ43_RS15830 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GWQ43_RS15855 ENOG4106H78 methyltransferase GWQ43_RS15860 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GWQ43_RS15865 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GWQ43_RS15895 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) GWQ43_RS15910 ENOG4108UAU isochorismatase GWQ43_RS15925 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GWQ43_RS15930 ENOG4108XHQ (2Fe-2S)-binding domain protein GWQ43_RS15935 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GWQ43_RS15945 ENOG4108IV0 ABC, transporter GWQ43_RS15950 ENOG4105C0Z ABC transporter GWQ43_RS15975 ENOG4105BZU Histidine kinase GWQ43_RS16005 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GWQ43_RS16010 ENOG4105FDP GntR family transcriptional regulator GWQ43_RS16020 ENOG4107RZC phospholipase d GWQ43_RS16030 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GWQ43_RS16035 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GWQ43_RS16040 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS16050 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GWQ43_RS16080 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS16105 ENOG4108UAU isochorismatase GWQ43_RS16130 ENOG4105E0A ABC, transporter GWQ43_RS16135 ENOG4105EHG Permease protein GWQ43_RS16145 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GWQ43_RS16150 ENOG4105CRW Short chain fatty acid transporter GWQ43_RS16160 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GWQ43_RS16175 ENOG4107RZZ dna polymerase iii epsilon subunit GWQ43_RS16180 ENOG4105BZS acriflavin resistance protein GWQ43_RS16185 ENOG4105ENT Efflux transporter rnd family, mfp subunit GWQ43_RS16190 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GWQ43_RS16195 ENOG4105D1A Methyltransferase GWQ43_RS16200 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GWQ43_RS16205 ENOG4105E9H Lytic Murein transglycosylase GWQ43_RS16210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GWQ43_RS16225 ENOG4105CK2 sodium dicarboxylate symporter GWQ43_RS16235 ENOG4105C72 UPF0176 protein GWQ43_RS16260 ENOG4108UIN ybak prolyl-trna synthetase associated region GWQ43_RS16265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWQ43_RS16275 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWQ43_RS16280 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GWQ43_RS16295 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GWQ43_RS16315 ENOG4108T2C cysteine dioxygenase type I GWQ43_RS16335 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GWQ43_RS16345 ENOG4105E9F Enoyl-CoA hydratase GWQ43_RS16360 ENOG4105CIS alcohol dehydrogenase GWQ43_RS16365 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GWQ43_RS16370 ENOG4105JQN Transcriptional regulator GWQ43_RS16385 ENOG4105HSS phospholipase C GWQ43_RS16395 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GWQ43_RS16400 ENOG4105C0A alcohol dehydrogenase GWQ43_RS16445 ENOG4105EAB amino acid AbC transporter GWQ43_RS16460 ENOG4105K89 arsenate reductase GWQ43_RS16465 ENOG4105CAU Arsenical resistance protein, ArsH GWQ43_RS16470 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS16475 ENOG4105DHQ Histidine kinase GWQ43_RS16490 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GWQ43_RS16495 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GWQ43_RS16500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GWQ43_RS16505 ENOG4108V1U phospholipid-binding protein GWQ43_RS16510 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GWQ43_RS16515 ENOG4105DR5 peptidase GWQ43_RS16520 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GWQ43_RS16525 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GWQ43_RS16535 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GWQ43_RS16540 ENOG4108UJD 30S ribosomal protein S9 GWQ43_RS16545 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GWQ43_RS16550 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS16555 ENOG4105CMS peptidase U62, modulator of DNA gyrase GWQ43_RS16560 ENOG4105N42 UPF0307 protein GWQ43_RS16580 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GWQ43_RS16590 ENOG4108ZXC Two component transcriptional regulator, luxr family GWQ43_RS16595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GWQ43_RS16600 ENOG4108VWS Yaeq family GWQ43_RS16610 ENOG4105J0Q Transcriptional regulator GWQ43_RS16625 ENOG4108VIA integral membrane protein GWQ43_RS16630 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GWQ43_RS16635 ENOG4108XTF Outer Membrane Lipoprotein GWQ43_RS16640 ENOG4107T4Z adenosine kinase GWQ43_RS16655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GWQ43_RS16660 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GWQ43_RS16665 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GWQ43_RS16670 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWQ43_RS16675 ENOG4105DFU Cell wall formation (By similarity) GWQ43_RS16680 ENOG4105IPS esterase GWQ43_RS16695 ENOG4105E2X shikimate dehydrogenase GWQ43_RS16700 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GWQ43_RS16710 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GWQ43_RS16715 ENOG4108Z20 Acyl-transferase GWQ43_RS16725 ENOG4108UJU UPF0301 protein GWQ43_RS16730 ENOG4105VCQ rubredoxin GWQ43_RS16740 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GWQ43_RS16745 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GWQ43_RS16760 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GWQ43_RS16770 ENOG4105VDW Csbd family GWQ43_RS16775 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GWQ43_RS16780 ENOG4105K46 50S ribosomal protein l27 GWQ43_RS16785 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GWQ43_RS16790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GWQ43_RS16815 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GWQ43_RS16820 ENOG4105CDV Ompa motb domain protein GWQ43_RS16830 ENOG4105CDA abc transporter atp-binding protein GWQ43_RS16835 ENOG4105DRP amino acid AbC transporter GWQ43_RS16840 ENOG4105EZ7 amino acid ABC transporter GWQ43_RS16850 ENOG4105CAK Cell division ATP-binding protein ftsE GWQ43_RS16855 ENOG4105CRP Part of the ABC transporter FtsEX involved in GWQ43_RS16860 ENOG4105CEN a g-specific adenine glycosylase GWQ43_RS16865 ENOG4105CNI cell division protein FtsW GWQ43_RS16870 ENOG4105CJN penicillin-binding protein GWQ43_RS16880 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GWQ43_RS16890 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS16895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS16900 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWQ43_RS16905 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GWQ43_RS16910 ENOG4105EJC lysr family transcriptional regulator GWQ43_RS16915 ENOG4105MGM doxx family GWQ43_RS16920 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GWQ43_RS16930 ENOG4105MPD Cytochrome GWQ43_RS16940 ENOG4105DSQ Nitric oxide reductase GWQ43_RS16960 ENOG4105D6U Sodium Glutamate Symporter GWQ43_RS16965 ENOG4105EAH synthase GWQ43_RS16975 ENOG4105M6F mutator MutT protein GWQ43_RS16980 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GWQ43_RS16985 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GWQ43_RS17005 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GWQ43_RS17010 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GWQ43_RS17025 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GWQ43_RS17030 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GWQ43_RS17040 ENOG4105C0R drug resistance transporter emrb qaca subfamily GWQ43_RS17050 ENOG4105C3R Methionine synthase GWQ43_RS17055 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GWQ43_RS17060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GWQ43_RS17065 ENOG4105CNM Receptor GWQ43_RS17075 ENOG4108SF5 RNA Polymerase GWQ43_RS17085 ENOG4108Z9W Outer membrane porin GWQ43_RS17095 ENOG4107QUT magnesium and cobalt transport protein CorA GWQ43_RS17105 ENOG4107QUT magnesium and cobalt transport protein CorA GWQ43_RS17120 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GWQ43_RS17125 ENOG4105DWF phosphomethylpyrimidine kinase GWQ43_RS17130 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GWQ43_RS17135 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GWQ43_RS17140 ENOG4105DFG type I secretion outer membrane protein GWQ43_RS17145 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GWQ43_RS17155 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GWQ43_RS17170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GWQ43_RS17175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GWQ43_RS17180 ENOG4105BZU Histidine kinase GWQ43_RS17190 ENOG4105P4J Allophanate hydrolase, subunit 1 GWQ43_RS17200 ENOG4105C7B Threonine dehydratase GWQ43_RS17205 ENOG4105W39 Membrane GWQ43_RS17230 ENOG4108JJ8 (ABC) transporter GWQ43_RS17235 ENOG4108JJ9 ABC, transporter GWQ43_RS17245 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GWQ43_RS17250 ENOG4105C4M (Ubiquinol oxidase) subunit I GWQ43_RS17260 ENOG4105C2X Arabinose 5-phosphate isomerase GWQ43_RS17265 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GWQ43_RS17280 ENOG4108IUZ ABC transporter GWQ43_RS17285 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GWQ43_RS17290 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GWQ43_RS17295 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GWQ43_RS17300 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GWQ43_RS17310 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GWQ43_RS17315 ENOG41082RQ UPF0102 protein GWQ43_RS17320 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GWQ43_RS17335 ENOG4105CAS nag kinase GWQ43_RS17355 ENOG4105D06 uba thif-type nad fad binding protein GWQ43_RS17360 ENOG4105CN1 protease GWQ43_RS17370 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GWQ43_RS17375 ENOG4107YZP Rhodanese domain protein GWQ43_RS17380 ENOG4105VW4 glutaredoxin 3 GWQ43_RS17385 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GWQ43_RS17390 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GWQ43_RS17400 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GWQ43_RS17405 ENOG4105MJ2 Competence protein GWQ43_RS17410 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GWQ43_RS17415 ENOG4105D05 Receptor GWQ43_RS17420 ENOG4105XJC Two component transcriptional regulator (Winged helix family GWQ43_RS17430 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GWQ43_RS17435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWQ43_RS17450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GWQ43_RS17455 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GWQ43_RS17465 ENOG4108Z0R Transferase GWQ43_RS17480 ENOG4105CNV Aldolase GWQ43_RS17485 ENOG4108IY8 ABC, transporter GWQ43_RS17515 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GWQ43_RS17545 ENOG4108MX3 Polysaccharide Biosynthesis Protein GWQ43_RS17550 ENOG4105C1B dTDP-glucose 4-6-dehydratase GWQ43_RS17555 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GWQ43_RS17560 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GWQ43_RS17570 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GWQ43_RS17580 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GWQ43_RS17585 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GWQ43_RS17590 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GWQ43_RS17600 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GWQ43_RS17605 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) GWQ43_RS17615 ENOG4105E39 Enoyl-CoA hydratase GWQ43_RS17630 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GWQ43_RS17635 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GWQ43_RS17645 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GWQ43_RS17695 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GWQ43_RS17720 ENOG4105SG9 biopolymer transport protein, ExbD GWQ43_RS17725 ENOG4105E02 MotA TolQ exbB proton channel GWQ43_RS17740 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GWQ43_RS17745 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GWQ43_RS17750 ENOG4105CNM Receptor GWQ43_RS17785 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GWQ43_RS17795 ENOG4108KK1 membrane protein AbrB duplication GWQ43_RS17815 ENOG4105GR3 Histidine kinase GWQ43_RS17830 ENOG4105CSH Transporter GWQ43_RS17835 ENOG4105ES4 Nitrilase GWQ43_RS17855 ENOG4105E2Y ABC, transporter GWQ43_RS17885 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GWQ43_RS17890 ENOG4108MG3 formate dehydrogenase GWQ43_RS17900 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GWQ43_RS17905 ENOG4105EM7 Selenocysteine-specific translation elongation factor GWQ43_RS17920 ENOG4108S8N class II Aldolase GWQ43_RS17935 ENOG4107RNH Outer membrane receptor FepA GWQ43_RS17940 ENOG4105D05 Receptor GWQ43_RS17955 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GWQ43_RS17970 ENOG4105DDW LysR family Transcriptional regulator GWQ43_RS17975 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) GWQ43_RS17985 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) GWQ43_RS17995 ENOG4105CIG ABC transporter GWQ43_RS18000 ENOG4108T0W nitrous oxide maturation protein NosY GWQ43_RS18015 ENOG4107QP8 phosphohexose isomerase GWQ43_RS18060 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GWQ43_RS18075 ENOG4105W2C Glycosyl transferase GWQ43_RS18085 ENOG4108IJ1 Dehydrogenase GWQ43_RS18100 ENOG4105ECX polysaccharide export GWQ43_RS18110 ENOG41090SZ ABC-2 type transporter GWQ43_RS18120 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GWQ43_RS18130 ENOG4105C2W permease GWQ43_RS18135 ENOG4105T38 integral membrane protein GWQ43_RS18140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS18145 ENOG4107Y9U Membrane GWQ43_RS18170 ENOG4108ZG0 Ompa motb domain protein GWQ43_RS18255 ENOG4105CS6 Rhs element vgr protein GWQ43_RS18265 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS18285 ENOG4105DHJ ABC, transporter GWQ43_RS18290 ENOG4105CY3 ABC transporter, permease GWQ43_RS18295 ENOG4107PE3 Mammalian cell entry related domain protein GWQ43_RS18310 ENOG4105DA5 (ABC) transporter GWQ43_RS18315 ENOG4105E3A (ABC) transporter GWQ43_RS18325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GWQ43_RS18335 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GWQ43_RS18340 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GWQ43_RS18350 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GWQ43_RS18355 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GWQ43_RS18365 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase GWQ43_RS18370 ENOG4107YU2 histidine triad (hIT) protein GWQ43_RS18375 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GWQ43_RS18380 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GWQ43_RS18390 ENOG4105C0H protease GWQ43_RS18395 ENOG4107QNR UPF0135 protein GWQ43_RS18400 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GWQ43_RS18405 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GWQ43_RS18410 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GWQ43_RS18415 ENOG4105EIX cytochrome c1 GWQ43_RS18420 ENOG4107MKT Stringent starvation protein a GWQ43_RS18425 ENOG4105KB2 stringent starvation protein b GWQ43_RS18430 ENOG4105ECW sulfate abc transporter GWQ43_RS18435 ENOG4108I5D sulfate abc transporter GWQ43_RS18440 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GWQ43_RS18460 ENOG4105C5I Dehydrogenase GWQ43_RS18470 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWQ43_RS18480 ENOG4105CH5 extracellular solute-binding protein, family 7 GWQ43_RS18485 ENOG4105EXW epimerase dehydratase GWQ43_RS18500 ENOG4105C01 Dihydroxy-acid dehydratase GWQ43_RS18505 ENOG4108WYP Transcriptional regulator GWQ43_RS18510 ENOG4108XM1 transcriptional regulator AsnC family GWQ43_RS18520 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GWQ43_RS18540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GWQ43_RS18545 ENOG4105CV8 reductase GWQ43_RS18555 ENOG4107QM5 aconitate hydratase GWQ43_RS18565 ENOG4105DHI Methyltransferase GWQ43_RS18595 ENOG4105F04 LysR family Transcriptional regulator GWQ43_RS18600 ENOG4105CSH Transporter GWQ43_RS18605 ENOG4105CHR reductase GWQ43_RS18610 ENOG4105EUB pirin domain protein GWQ43_RS18615 ENOG4105CHJ isochorismatase hydrolase GWQ43_RS18620 ENOG4105CHJ isochorismatase hydrolase GWQ43_RS18625 ENOG4105EUB pirin domain protein GWQ43_RS18630 ENOG4105JQN Transcriptional regulator GWQ43_RS18635 ENOG4105VDW Csbd family GWQ43_RS18640 ENOG4105K3G Periplasmic Protein GWQ43_RS18650 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GWQ43_RS18670 ENOG4108NS2 receptor GWQ43_RS18695 ENOG4108SF5 RNA Polymerase GWQ43_RS18705 ENOG4108YXU transcriptional regulator AsnC family GWQ43_RS18715 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GWQ43_RS18730 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GWQ43_RS18735 ENOG4105BZ9 Cytochrome C oxidase, subunit I GWQ43_RS18745 ENOG4107QS1 Cytochrome C Oxidase, Subunit III GWQ43_RS18770 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GWQ43_RS18785 ENOG4107RNH Outer membrane receptor FepA GWQ43_RS18790 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWQ43_RS18800 ENOG4107QPD alcohol dehydrogenase GWQ43_RS18805 ENOG4105DZQ phospholipase D Transphosphatidylase GWQ43_RS18810 ENOG4105X23 Endonuclease Exonuclease phosphatase GWQ43_RS18815 ENOG4105C9M aspartyl-trna synthetase GWQ43_RS18840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GWQ43_RS18850 ENOG4105CI2 imidazolone-5-propionate hydrolase GWQ43_RS18870 ENOG4105C84 Histidine ammonia-lyase GWQ43_RS18875 ENOG4105CGP Urocanate hydratase GWQ43_RS18905 ENOG4105F27 Major Facilitator GWQ43_RS18915 ENOG4108Z6Z Transcriptional regulator GWQ43_RS18935 ENOG4105CYM Glutathione S-transferase GWQ43_RS18960 ENOG4105CGF Aromatic amino acid aminotransferase GWQ43_RS18965 ENOG4105M2Z protein tyrosine serine phosphatase GWQ43_RS18970 ENOG4105CY0 Metallo-Beta-Lactamase GWQ43_RS18990 ENOG4105CIF Ornithine Cyclodeaminase GWQ43_RS18995 ENOG4108EGU NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GWQ43_RS19050 ENOG4105DRR Transcriptional regulator, GntR family GWQ43_RS19060 ENOG4105C2C drug resistance transporter, Bcr CflA GWQ43_RS19075 ENOG4105CZM Major Facilitator GWQ43_RS19080 ENOG4105KME endoribonuclease L-psp GWQ43_RS19090 ENOG4105ERH Fumarylacetoacetate hydrolase GWQ43_RS19095 ENOG4105C6F GntR Family Transcriptional Regulator GWQ43_RS19100 ENOG4108SF5 RNA Polymerase GWQ43_RS19105 ENOG4108S3W Anti-feci sigma factor, fecr GWQ43_RS19110 ENOG4105CNM Receptor GWQ43_RS19120 ENOG4107RDB Major Facilitator GWQ43_RS19130 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GWQ43_RS19135 ENOG4105D49 3-dehydroquinate synthase GWQ43_RS19140 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GWQ43_RS19145 ENOG4108JQC penicillin-binding protein 1A GWQ43_RS19155 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GWQ43_RS19160 ENOG4105BZU Histidine kinase GWQ43_RS19165 ENOG4105CRE cytochrome C GWQ43_RS19170 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GWQ43_RS19180 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GWQ43_RS19185 ENOG4105D52 delta-aminolevulinic acid dehydratase GWQ43_RS19190 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GWQ43_RS19210 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GWQ43_RS19215 ENOG4108ZT0 50S ribosomal protein l17 GWQ43_RS19220 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWQ43_RS19225 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GWQ43_RS19230 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GWQ43_RS19235 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GWQ43_RS19250 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GWQ43_RS19255 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GWQ43_RS19260 ENOG4105VPB 50S ribosomal protein L30 GWQ43_RS19265 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GWQ43_RS19270 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GWQ43_RS19275 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GWQ43_RS19280 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GWQ43_RS19285 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GWQ43_RS19290 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GWQ43_RS19295 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GWQ43_RS19300 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GWQ43_RS19325 ENOG4107QZV Type I secretion membrane fusion protein GWQ43_RS19340 ENOG4105DFG type I secretion outer membrane protein GWQ43_RS19355 ENOG4107QPN acyl-Coa dehydrogenase GWQ43_RS19360 ENOG4105CHU acetyl-coa acetyltransferase GWQ43_RS19365 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWQ43_RS19370 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GWQ43_RS19385 ENOG4105CEY Amp-dependent synthetase and ligase GWQ43_RS19390 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GWQ43_RS19395 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GWQ43_RS19400 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GWQ43_RS19415 ENOG4105D7T ABC transporter GWQ43_RS19435 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GWQ43_RS19440 ENOG41084PQ 50s ribosomal protein l29 GWQ43_RS19445 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GWQ43_RS19450 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GWQ43_RS19455 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GWQ43_RS19460 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GWQ43_RS19465 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GWQ43_RS19470 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GWQ43_RS19475 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GWQ43_RS19480 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GWQ43_RS19485 ENOG4108IJ7 Glycine betaine GWQ43_RS19490 ENOG4108HQS Glycine betaine GWQ43_RS19495 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GWQ43_RS19500 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GWQ43_RS19505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWQ43_RS19510 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GWQ43_RS19515 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GWQ43_RS19550 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWQ43_RS19555 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWQ43_RS19560 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GWQ43_RS19565 ENOG4108VZM 50s ribosomal protein L10 GWQ43_RS19570 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GWQ43_RS19595 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GWQ43_RS19615 ENOG4105FA0 parb-like partition protein GWQ43_RS19620 ENOG4107QJE Chromosome Partitioning Protein GWQ43_RS19625 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GWQ43_RS19630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GWQ43_RS19635 ENOG4105CHM Aminotransferase GWQ43_RS19645 ENOG4107S1Q Phosphatase GWQ43_RS19650 ENOG4105BZU Histidine kinase GWQ43_RS19655 ENOG4105DJ4 phosphatidylserine decarboxylase GWQ43_RS19665 ENOG4105C7B Threonine dehydratase GWQ43_RS19675 ENOG4105JAB phenazine biosynthesis protein, phzf family GWQ43_RS19710 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GWQ43_RS19740 ENOG4105CP9 extracellular ligand-binding receptor GWQ43_RS19745 ENOG4105C32 Amino acid ABC transporter (Permease) GWQ43_RS19755 ENOG4105C0Z ABC transporter GWQ43_RS19760 ENOG4108IV0 ABC, transporter GWQ43_RS19775 ENOG4108UAU isochorismatase GWQ43_RS19800 ENOG4105CH6 catalase GWQ43_RS19805 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GWQ43_RS19810 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GWQ43_RS19815 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GWQ43_RS19820 ENOG4105VG0 50S ribosomal protein l34 GWQ43_RS20075 ENOG4105EQR Transposase IS116 IS110 IS902 GWQ43_RS20125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GWQ43_RS20130 ENOG4105KT5 UmuD protein GWQ43_RS20135 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWQ43_RS20195 ENOG4108UXE Protein tyrosine phosphatase GWQ43_RS20200 ENOG4105D6J arsenicaL-resistance protein GWQ43_RS20300 ENOG4105W1Y Transcriptional regulator GWQ43_RS20305 ENOG4108VSE mercuric transport protein GWQ43_RS20335 ENOG4105BZU Histidine kinase GWQ43_RS20395 ENOG4108C33 Resolvase GWQ43_RS20430 ENOG4108R0M Aminoglycoside GWQ43_RS20435 ENOG4108C33 Resolvase