locus-tag	class	description
GWQ43_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWQ43_RS00010	COG0592	DNA-directed DNA polymerase activity
GWQ43_RS00020	COG1187	pseudouridine synthase activity
GWQ43_RS00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS00060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS00065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_RS00085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS00105	COG2070	2-Nitropropane dioxygenase
GWQ43_RS00115	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS00125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS00145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWQ43_RS00170	COG0583	DNA-binding transcription factor activity
GWQ43_RS00180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS00185	COG1802	Transcriptional regulator
GWQ43_RS00190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS00195	COG2271	Major facilitator Superfamily
GWQ43_RS00205	COG0436	Aminotransferase
GWQ43_RS00215	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS00230	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_RS00240	COG0596	Alpha beta hydrolase
GWQ43_RS00240	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_RS00245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS00260	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS00270	COG0697	spore germination
GWQ43_RS00275	COG0583	DNA-binding transcription factor activity
GWQ43_RS00285	COG3842	ATPase activity
GWQ43_RS00295	COG0436	Aminotransferase
GWQ43_RS00305	COG0523	cobalamin synthesis protein
GWQ43_RS00360	COG1846	Transcriptional regulator
GWQ43_RS00380	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_RS00385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_RS00390	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GWQ43_RS00400	COG4638	Rieske (2fe-2S)
GWQ43_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS00505	COG1595	DNA-templated transcription, initiation
GWQ43_RS00510	COG4608	Belongs to the ABC transporter superfamily
GWQ43_RS00515	COG0444	Belongs to the ABC transporter superfamily
GWQ43_RS00520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_RS00535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWQ43_RS00540	COG1595	DNA-templated transcription, initiation
GWQ43_RS00545	COG3712	iron ion homeostasis
GWQ43_RS00550	COG4774	siderophore transport
GWQ43_RS00555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWQ43_RS00560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWQ43_RS00575	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_RS00580	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_RS00585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWQ43_RS00590	COG2011	ABC-type metal ion transport system permease component
GWQ43_RS00615	COG1464	Belongs to the NlpA lipoprotein family
GWQ43_RS00625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_RS00645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_RS00650	COG0431	NADPH-dependent FMN reductase
GWQ43_RS00685	COG4149	molybdate abc transporter
GWQ43_RS00695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWQ43_RS00700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWQ43_RS00710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS00730	COG0028	Belongs to the TPP enzyme family
GWQ43_RS00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS00765	COG2922	Belongs to the Smg family
GWQ43_RS00785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWQ43_RS00790	COG0183	Belongs to the thiolase family
GWQ43_RS00795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWQ43_RS00800	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS00820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWQ43_RS00830	COG0018	arginyl-trna synthetase
GWQ43_RS00850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_RS00865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWQ43_RS00870	COG4774	siderophore transport
GWQ43_RS00875	COG0066	3-isopropylmalate dehydratase activity
GWQ43_RS00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWQ43_RS00885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_RS00890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS00895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS00905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS00910	COG1335	isochorismatase
GWQ43_RS00915	COG0583	DNA-binding transcription factor activity
GWQ43_RS00935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWQ43_RS00940	COG1280	lysine exporter protein (LysE YggA)
GWQ43_RS00945	COG0513	Belongs to the DEAD box helicase family
GWQ43_RS00955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWQ43_RS00970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWQ43_RS00985	COG0154	amidase activity
GWQ43_RS01000	COG0583	DNA-binding transcription factor activity
GWQ43_RS01030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWQ43_RS01035	COG1127	ABC transporter
GWQ43_RS01040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_RS01040	COG3218	ABC-type transport auxiliary lipoprotein component
GWQ43_RS01055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_RS01060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS01070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS01100	COG0583	DNA-binding transcription factor activity
GWQ43_RS01120	COG3093	addiction module antidote protein HigA
GWQ43_RS01145	COG2358	TRAP transporter, solute receptor (TAXI family
GWQ43_RS01155	COG0564	pseudouridine synthase activity
GWQ43_RS01160	COG0252	asparaginase activity
GWQ43_RS01185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWQ43_RS01190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWQ43_RS01195	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS01215	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS01240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_RS01250	COG3712	iron ion homeostasis
GWQ43_RS01270	COG0758	DNA mediated transformation
GWQ43_RS01275	COG0242	peptide deformylase activity
GWQ43_RS01280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWQ43_RS01285	COG0697	spore germination
GWQ43_RS01300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS01315	COG4336	lyase activity
GWQ43_RS01320	COG0583	DNA-binding transcription factor activity
GWQ43_RS01325	COG0859	PFAM glycosyl transferase family 9
GWQ43_RS01335	COG1278	Cold shock
GWQ43_RS01340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWQ43_RS01345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GWQ43_RS01350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GWQ43_RS01350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GWQ43_RS01360	COG1686	Belongs to the peptidase S11 family
GWQ43_RS01370	COG2921	Belongs to the UPF0250 family
GWQ43_RS01375	COG0321	lipoyl(octanoyl) transferase activity
GWQ43_RS01395	COG1024	Enoyl-CoA hydratase
GWQ43_RS01400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWQ43_RS01410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWQ43_RS01455	COG0826	peptidase U32
GWQ43_RS01465	COG3154	lipid carrier protein
GWQ43_RS01490	COG0134	indole-3-glycerol-phosphate synthase activity
GWQ43_RS01495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWQ43_RS01500	COG0512	Glutamine amidotransferase of anthranilate synthase
GWQ43_RS01510	COG0546	phosphoglycolate phosphatase activity
GWQ43_RS01520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWQ43_RS01525	COG2967	ApaG domain
GWQ43_RS01530	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWQ43_RS01535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_RS01540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWQ43_RS01550	COG0840	transmembrane signaling receptor activity
GWQ43_RS01560	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS01565	COG3433	isochorismatase activity
GWQ43_RS01565	COG1535	isochorismatase
GWQ43_RS01570	COG1169	isochorismate synthase
GWQ43_RS01585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWQ43_RS01585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWQ43_RS01590	COG1535	isochorismatase
GWQ43_RS01590	COG3433	isochorismatase activity
GWQ43_RS01595	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWQ43_RS01625	COG0683	leucine binding
GWQ43_RS01640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS01675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GWQ43_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWQ43_RS01685	COG2819	hydrolase of the alpha beta superfamily
GWQ43_RS01690	COG0513	Belongs to the DEAD box helicase family
GWQ43_RS01695	COG2814	Major facilitator Superfamily
GWQ43_RS01705	COG0583	DNA-binding transcription factor activity
GWQ43_RS01715	COG1253	flavin adenine dinucleotide binding
GWQ43_RS01750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWQ43_RS01765	COG2311	Membrane
GWQ43_RS01800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_RS01820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS01825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_RS01835	COG0583	DNA-binding transcription factor activity
GWQ43_RS01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_RS01850	COG0765	amino acid transport
GWQ43_RS01855	COG0765	amino acid transport
GWQ43_RS01860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_RS01870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_RS01885	COG3391	amine dehydrogenase activity
GWQ43_RS01895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWQ43_RS01920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWQ43_RS01925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWQ43_RS01930	COG0210	DNA helicase
GWQ43_RS01945	COG0070	glutamate synthase
GWQ43_RS01945	COG0069	glutamate synthase activity
GWQ43_RS01945	COG0067	glutamate synthase
GWQ43_RS01950	COG1024	Enoyl-CoA hydratase
GWQ43_RS01960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS01965	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWQ43_RS01995	COG2918	glutathione biosynthetic process
GWQ43_RS02005	COG2197	response regulator
GWQ43_RS02010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWQ43_RS02020	COG2223	nitrite transmembrane transporter activity
GWQ43_RS02025	COG2860	membrane
GWQ43_RS02030	COG1346	cytolysis
GWQ43_RS02045	COG0251	oxidation-reduction process
GWQ43_RS02080	COG1280	lysine exporter protein (LysE YggA)
GWQ43_RS02090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWQ43_RS02105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWQ43_RS02120	COG2096	Adenosyltransferase
GWQ43_RS02135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWQ43_RS02140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWQ43_RS02150	COG0523	cobalamin synthesis protein
GWQ43_RS02155	COG0735	belongs to the Fur family
GWQ43_RS02165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWQ43_RS02170	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWQ43_RS02175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWQ43_RS02185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWQ43_RS02190	COG1560	Kdo2-lipid A biosynthetic process
GWQ43_RS02200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWQ43_RS02205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWQ43_RS02210	COG1950	PFAM Membrane protein of
GWQ43_RS02245	COG0275	rRNA processing
GWQ43_RS02250	COG0730	response to heat
GWQ43_RS02255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWQ43_RS02260	COG0129	dihydroxy-acid dehydratase activity
GWQ43_RS02270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS02280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS02295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWQ43_RS02315	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS02325	COG0628	permease
GWQ43_RS02335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS02340	COG0656	L-ascorbic acid biosynthetic process
GWQ43_RS02345	COG2814	Major facilitator Superfamily
GWQ43_RS02350	COG0583	DNA-binding transcription factor activity
GWQ43_RS02360	COG3685	Protein conserved in bacteria
GWQ43_RS02380	COG1846	Transcriptional regulator
GWQ43_RS02395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_RS02405	COG0789	Transcriptional regulator
GWQ43_RS02415	COG4774	siderophore transport
GWQ43_RS02420	COG4607	ABC-type enterochelin transport system periplasmic component
GWQ43_RS02425	COG4604	ABC transporter, ATP-binding protein
GWQ43_RS02430	COG4605	iron ion homeostasis
GWQ43_RS02435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWQ43_RS02450	COG0277	FAD linked oxidase domain protein
GWQ43_RS02455	COG1304	FMN binding
GWQ43_RS02460	COG2186	Transcriptional regulator
GWQ43_RS02480	COG2188	Transcriptional regulator
GWQ43_RS02485	COG1522	sequence-specific DNA binding
GWQ43_RS02490	COG3844	kynureninase activity
GWQ43_RS02495	COG1113	amino acid transport
GWQ43_RS02530	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS02535	COG1349	DNA-binding transcription factor activity
GWQ43_RS02540	COG3842	ATPase activity
GWQ43_RS02555	COG0395	ABC-type sugar transport system, permease component
GWQ43_RS02580	COG0861	Integral membrane protein TerC family
GWQ43_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_RS02595	COG1671	Belongs to the UPF0178 family
GWQ43_RS02605	COG2161	toxin-antitoxin pair type II binding
GWQ43_RS02615	COG1418	mRNA catabolic process
GWQ43_RS02625	COG4948	Mandelate Racemase Muconate Lactonizing
GWQ43_RS02635	COG0477	Major facilitator Superfamily
GWQ43_RS02650	COG0154	amidase activity
GWQ43_RS02660	COG0583	DNA-binding transcription factor activity
GWQ43_RS02685	COG0326	Molecular chaperone. Has ATPase activity
GWQ43_RS02690	COG4774	siderophore transport
GWQ43_RS02695	COG3128	pkhd-type hydroxylase
GWQ43_RS02720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWQ43_RS02725	COG1652	LysM domain
GWQ43_RS02740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWQ43_RS02750	COG0582	viral genome integration into host DNA
GWQ43_RS02800	COG0629	single-stranded DNA binding
GWQ43_RS02805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWQ43_RS02965	COG2003	Belongs to the UPF0758 family
GWQ43_RS03095	COG0789	Transcriptional regulator
GWQ43_RS03105	COG2608	mercury ion transmembrane transporter activity
GWQ43_RS03110	COG2608	mercury ion transmembrane transporter activity
GWQ43_RS03115	COG0789	Transcriptional regulator
GWQ43_RS03125	COG1120	ATPase activity
GWQ43_RS03140	COG3586	endonuclease activity
GWQ43_RS03150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWQ43_RS03160	COG0583	DNA-binding transcription factor activity
GWQ43_RS03170	COG0464	growth
GWQ43_RS03200	COG1535	isochorismatase
GWQ43_RS03200	COG3433	isochorismatase activity
GWQ43_RS03225	COG0583	DNA-binding transcription factor activity
GWQ43_RS03230	COG0387	Pfam Sodium calcium exchanger
GWQ43_RS03245	COG0477	Major facilitator Superfamily
GWQ43_RS03250	COG0235	Class ii aldolase
GWQ43_RS03260	COG3391	amine dehydrogenase activity
GWQ43_RS03265	COG0590	tRNA wobble adenosine to inosine editing
GWQ43_RS03270	COG3257	ureidoglycine aminohydrolase activity
GWQ43_RS03275	COG0583	DNA-binding transcription factor activity
GWQ43_RS03280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWQ43_RS03285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_RS03285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_RS03295	COG0489	protein tyrosine kinase activity
GWQ43_RS03315	COG1982	Orn Lys Arg decarboxylase major
GWQ43_RS03320	COG2081	HI0933 family
GWQ43_RS03325	COG0509	glycine decarboxylation via glycine cleavage system
GWQ43_RS03335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWQ43_RS03340	COG1765	OsmC-like protein
GWQ43_RS03345	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_RS03370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GWQ43_RS03375	COG0469	pyruvate kinase activity
GWQ43_RS03380	COG3193	protein, possibly involved in utilization of glycolate and propanediol
GWQ43_RS03390	COG2084	Dehydrogenase
GWQ43_RS03395	COG3622	Belongs to the hyi family
GWQ43_RS03400	COG3960	tartronate-semialdehyde synthase activity
GWQ43_RS03405	COG0583	DNA-binding transcription factor activity
GWQ43_RS03415	COG2233	PERMEase
GWQ43_RS03420	COG1942	4-Oxalocrotonate Tautomerase
GWQ43_RS03425	COG0235	Class ii aldolase
GWQ43_RS03435	COG3195	allantoin biosynthetic process
GWQ43_RS03435	COG3648	Uricase
GWQ43_RS03445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWQ43_RS03450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWQ43_RS03465	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS03475	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS03485	COG0277	FAD linked oxidase domain protein
GWQ43_RS03495	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_RS03500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWQ43_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_RS03520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWQ43_RS03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWQ43_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWQ43_RS03550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWQ43_RS03555	COG0193	aminoacyl-tRNA hydrolase activity
GWQ43_RS03565	COG0012	GTP binding
GWQ43_RS03570	COG0582	viral genome integration into host DNA
GWQ43_RS03580	COG1111	helicase
GWQ43_RS03580	COG1205	dead DEAH box helicase
GWQ43_RS03585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWQ43_RS03650	COG0488	(ABC) transporter
GWQ43_RS03665	COG0288	reversible hydration of carbon dioxide
GWQ43_RS03670	COG0583	DNA-binding transcription factor activity
GWQ43_RS03690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWQ43_RS03700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWQ43_RS03710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_RS03715	COG3088	subunit of a heme lyase
GWQ43_RS03720	COG4235	cytochrome complex assembly
GWQ43_RS03725	COG0785	Cytochrome C biogenesis protein
GWQ43_RS03735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_RS03735	COG2169	Transcriptional regulator
GWQ43_RS03755	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS03765	COG0411	ABC transporter
GWQ43_RS03775	COG1858	cytochrome C peroxidase
GWQ43_RS03780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWQ43_RS03785	COG1959	2 iron, 2 sulfur cluster binding
GWQ43_RS03790	COG2346	COG2346, Truncated hemoglobins
GWQ43_RS03795	COG0463	Glycosyl transferase, family 2
GWQ43_RS03835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWQ43_RS03840	COG3383	formate dehydrogenase (NAD+) activity
GWQ43_RS03855	COG1910	domain protein
GWQ43_RS03860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWQ43_RS03870	COG0303	'Molybdopterin
GWQ43_RS03875	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWQ43_RS03880	COG0314	molybdopterin synthase activity
GWQ43_RS03890	COG0315	cyclic pyranopterin monophosphate synthase activity
GWQ43_RS03920	COG0678	peroxiredoxin activity
GWQ43_RS03935	COG0697	spore germination
GWQ43_RS03940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWQ43_RS03975	COG2814	Major facilitator Superfamily
GWQ43_RS04015	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWQ43_RS04020	COG4535	Mg2 and Co2 transporter CorC
GWQ43_RS04025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWQ43_RS04030	COG1702	phosphate starvation-inducible protein PhoH
GWQ43_RS04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWQ43_RS04050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWQ43_RS04055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWQ43_RS04060	COG1862	Preprotein translocase
GWQ43_RS04065	COG0343	queuine tRNA-ribosyltransferase activity
GWQ43_RS04070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWQ43_RS04075	COG2027	D-alanyl-D-alanine carboxypeptidase
GWQ43_RS04080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWQ43_RS04090	COG4575	ribosome binding
GWQ43_RS04105	COG0583	DNA-binding transcription factor activity
GWQ43_RS04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_RS04135	COG0154	amidase activity
GWQ43_RS04145	COG0477	Major facilitator Superfamily
GWQ43_RS04160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWQ43_RS04170	COG0436	Aminotransferase
GWQ43_RS04180	COG0281	malic enzyme
GWQ43_RS04180	COG0280	phosphate acetyltransferase
GWQ43_RS04190	COG2732	(Barnase) inhibitor
GWQ43_RS04195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWQ43_RS04200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWQ43_RS04205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWQ43_RS04210	COG0126	phosphoglycerate kinase activity
GWQ43_RS04230	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWQ43_RS04240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWQ43_RS04245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWQ43_RS04250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWQ43_RS04255	COG0009	L-threonylcarbamoyladenylate synthase
GWQ43_RS04260	COG0596	Alpha beta hydrolase
GWQ43_RS04265	COG2030	dehydratase
GWQ43_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS04270	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS04280	COG0405	Gamma-glutamyltransferase
GWQ43_RS04290	COG0579	oxidoreductase
GWQ43_RS04295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_RS04300	COG0259	pyridoxamine-phosphate oxidase activity
GWQ43_RS04310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWQ43_RS04325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWQ43_RS04330	COG1215	transferase activity, transferring glycosyl groups
GWQ43_RS04340	COG0488	(ABC) transporter
GWQ43_RS04360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWQ43_RS04365	COG2894	cell division
GWQ43_RS04375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWQ43_RS04380	COG1271	oxidase subunit
GWQ43_RS04385	COG1294	oxidase, subunit
GWQ43_RS04390	COG0038	chloride channel
GWQ43_RS04400	COG0514	ATP-dependent DNA helicase (RecQ)
GWQ43_RS04405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWQ43_RS04410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWQ43_RS04415	COG0633	Ferredoxin
GWQ43_RS04430	COG2001	Belongs to the MraZ family
GWQ43_RS04435	COG0275	rRNA processing
GWQ43_RS04440	COG3116	cell division
GWQ43_RS04450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWQ43_RS04455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWQ43_RS04460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWQ43_RS04470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWQ43_RS04475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWQ43_RS04480	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWQ43_RS04485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWQ43_RS04500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWQ43_RS04510	COG0739	heme binding
GWQ43_RS04510	COG0741	lytic transglycosylase activity
GWQ43_RS04510	COG1196	nuclear chromosome segregation
GWQ43_RS04515	COG0653	protein targeting
GWQ43_RS04525	COG2239	Acts as a magnesium transporter
GWQ43_RS04535	COG1473	amidohydrolase
GWQ43_RS04540	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_RS04550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWQ43_RS04550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS04565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWQ43_RS04570	COG2011	ABC-type metal ion transport system permease component
GWQ43_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_RS04585	COG0765	amino acid transport
GWQ43_RS04590	COG1126	abc transporter atp-binding protein
GWQ43_RS04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_RS04620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWQ43_RS04625	COG0700	Nucleoside recognition
GWQ43_RS04640	COG0204	Acyl-transferase
GWQ43_RS04645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWQ43_RS04650	COG0751	glycine-tRNA ligase activity
GWQ43_RS04655	COG0752	glycyl-tRNA synthetase alpha subunit
GWQ43_RS04665	COG1024	Enoyl-CoA hydratase
GWQ43_RS04675	COG1309	transcriptional regulator
GWQ43_RS04700	COG1573	uracil-dna glycosylase
GWQ43_RS04705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWQ43_RS04710	COG0617	tRNA 3'-terminal CCA addition
GWQ43_RS04720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWQ43_RS04725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWQ43_RS04735	COG1953	Uracil, thiamine, allantoin
GWQ43_RS04740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWQ43_RS04745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWQ43_RS04750	COG0586	Pfam SNARE associated Golgi protein
GWQ43_RS04755	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWQ43_RS04760	COG0802	atpase or kinase
GWQ43_RS04770	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS04805	COG0463	Glycosyl transferase, family 2
GWQ43_RS04810	COG0280	phosphate acetyltransferase
GWQ43_RS04810	COG0281	malic enzyme
GWQ43_RS04815	COG0583	DNA-binding transcription factor activity
GWQ43_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS04825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_RS04875	COG1733	regulation of RNA biosynthetic process
GWQ43_RS04880	COG2910	NAD(P)H-binding
GWQ43_RS04890	COG2223	nitrite transmembrane transporter activity
GWQ43_RS04895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWQ43_RS04900	COG4974	Belongs to the 'phage' integrase family
GWQ43_RS04905	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWQ43_RS04910	COG4149	molybdate abc transporter
GWQ43_RS04915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_RS04930	COG1074	ATP-dependent DNA helicase activity
GWQ43_RS04965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS04985	COG3391	amine dehydrogenase activity
GWQ43_RS04990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWQ43_RS04995	COG0505	Belongs to the CarA family
GWQ43_RS05000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWQ43_RS05025	COG2233	PERMEase
GWQ43_RS05030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWQ43_RS05035	COG1534	Rna-binding protein
GWQ43_RS05040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWQ43_RS05045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWQ43_RS05055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWQ43_RS05065	COG0248	Ppx GppA phosphatase
GWQ43_RS05070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWQ43_RS05090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWQ43_RS05095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWQ43_RS05110	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS05115	COG2205	protein histidine kinase activity
GWQ43_RS05145	COG1231	oxidoreductase activity
GWQ43_RS05150	COG2010	Cytochrome c
GWQ43_RS05155	COG2323	membrane
GWQ43_RS05170	COG1368	sulfuric ester hydrolase activity
GWQ43_RS05200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_RS05205	COG3327	negative regulation of DNA-templated transcription, initiation
GWQ43_RS05210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWQ43_RS05225	COG0009	L-threonylcarbamoyladenylate synthase
GWQ43_RS05230	COG1994	Peptidase M50
GWQ43_RS05235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWQ43_RS05240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWQ43_RS05255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWQ43_RS05265	COG0156	8-amino-7-oxononanoate synthase activity
GWQ43_RS05270	COG2124	cytochrome p450
GWQ43_RS05275	COG3135	benzoate transporter
GWQ43_RS05285	COG2850	peptidyl-arginine hydroxylation
GWQ43_RS05295	COG3391	amine dehydrogenase activity
GWQ43_RS05335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_RS05340	COG1136	(ABC) transporter
GWQ43_RS05340	COG0577	efflux transmembrane transporter activity
GWQ43_RS05345	COG1538	Outer membrane efflux protein
GWQ43_RS05350	COG0363	glucosamine-6-phosphate deaminase activity
GWQ43_RS05355	COG1132	(ABC) transporter
GWQ43_RS05365	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_RS05385	COG0668	transmembrane transport
GWQ43_RS05430	COG0154	amidase activity
GWQ43_RS05435	COG2031	fatty acid transporter
GWQ43_RS05455	COG1253	flavin adenine dinucleotide binding
GWQ43_RS05460	COG1968	undecaprenyl-diphosphatase activity
GWQ43_RS05480	COG0215	cysteine-tRNA ligase activity
GWQ43_RS05490	COG0825	malonyl-CoA metabolic process
GWQ43_RS05495	COG0037	tRNA processing
GWQ43_RS05515	COG0330	HflC and HflK could
GWQ43_RS05585	COG1201	RNA secondary structure unwinding
GWQ43_RS05600	COG2003	Belongs to the UPF0758 family
GWQ43_RS05670	COG2948	multi-organism process
GWQ43_RS05775	COG4208	sulfate ABC transporter
GWQ43_RS05780	COG3842	ATPase activity
GWQ43_RS05790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWQ43_RS05815	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS05820	COG4773	Receptor
GWQ43_RS05835	COG1304	FMN binding
GWQ43_RS05840	COG0435	Glutathione S-transferase
GWQ43_RS05845	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWQ43_RS05865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWQ43_RS05870	COG2363	Small membrane protein
GWQ43_RS05875	COG0598	Magnesium transport protein CorA
GWQ43_RS05880	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS05890	COG0747	negative chemotaxis
GWQ43_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_RS05905	COG4172	Belongs to the ABC transporter superfamily
GWQ43_RS05915	COG3284	Transcriptional regulator
GWQ43_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS05925	COG1454	alcohol dehydrogenase
GWQ43_RS05955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS05965	COG0183	Belongs to the thiolase family
GWQ43_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS05985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWQ43_RS06010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS06040	COG3829	transcription factor binding
GWQ43_RS06060	COG0039	L-malate dehydrogenase activity
GWQ43_RS06065	COG2188	Transcriptional regulator
GWQ43_RS06070	COG2009	succinate dehydrogenase
GWQ43_RS06080	COG1053	succinate dehydrogenase
GWQ43_RS06085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWQ43_RS06090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWQ43_RS06095	COG0372	Belongs to the citrate synthase family
GWQ43_RS06100	COG2186	Transcriptional regulator
GWQ43_RS06105	COG1620	l-lactate permease
GWQ43_RS06110	COG0281	malic enzyme
GWQ43_RS06110	COG0280	phosphate acetyltransferase
GWQ43_RS06115	COG0567	Dehydrogenase, E1 component
GWQ43_RS06120	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_RS06125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWQ43_RS06130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWQ43_RS06150	COG2183	response to ionizing radiation
GWQ43_RS06155	COG1199	ATP-dependent helicase activity
GWQ43_RS06165	COG1733	regulation of RNA biosynthetic process
GWQ43_RS06185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWQ43_RS06185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS06200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_RS06200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS06215	COG0564	pseudouridine synthase activity
GWQ43_RS06225	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWQ43_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS06235	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GWQ43_RS06265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWQ43_RS06270	COG1187	pseudouridine synthase activity
GWQ43_RS06275	COG0779	Required for maturation of 30S ribosomal subunits
GWQ43_RS06280	COG2251	uridine kinase activity
GWQ43_RS06280	COG0195	Participates in both transcription termination and antitermination
GWQ43_RS06285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWQ43_RS06290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWQ43_RS06295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWQ43_RS06305	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_RS06315	COG4160	amino acid transport
GWQ43_RS06320	COG4215	(ABC) transporter
GWQ43_RS06340	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWQ43_RS06350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWQ43_RS06360	COG0456	acetyltransferase
GWQ43_RS06365	COG0501	Belongs to the peptidase M48B family
GWQ43_RS06380	COG1722	exodeoxyribonuclease VII activity
GWQ43_RS06385	COG0142	geranyltranstransferase activity
GWQ43_RS06395	COG1469	GTP cyclohydrolase I activity
GWQ43_RS06400	COG0360	Binds together with S18 to 16S ribosomal RNA
GWQ43_RS06405	COG2965	DNA replication, synthesis of RNA primer
GWQ43_RS06410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWQ43_RS06420	COG0305	Participates in initiation and elongation during chromosome replication
GWQ43_RS06430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWQ43_RS06435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWQ43_RS06440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWQ43_RS06450	COG0436	Aminotransferase
GWQ43_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWQ43_RS06470	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GWQ43_RS06475	COG1562	ergosterol biosynthetic process
GWQ43_RS06480	COG1562	ergosterol biosynthetic process
GWQ43_RS06485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWQ43_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS06515	COG3842	ATPase activity
GWQ43_RS06520	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWQ43_RS06525	COG1177	transmembrane transport
GWQ43_RS06530	COG1393	Belongs to the ArsC family
GWQ43_RS06535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWQ43_RS06540	COG0704	Plays a role in the regulation of phosphate uptake
GWQ43_RS06545	COG5001	Diguanylate cyclase
GWQ43_RS06550	COG0659	secondary active sulfate transmembrane transporter activity
GWQ43_RS06555	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWQ43_RS06560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWQ43_RS06560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWQ43_RS06565	COG1643	Atp-dependent helicase
GWQ43_RS06575	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS06580	COG0726	polysaccharide deacetylase
GWQ43_RS06595	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS06620	COG1132	(ABC) transporter
GWQ43_RS06635	COG1530	ribonuclease E activity
GWQ43_RS06670	COG2186	Transcriptional regulator
GWQ43_RS06675	COG0277	FAD linked oxidase domain protein
GWQ43_RS06680	COG0277	FAD linked oxidase domain protein
GWQ43_RS06685	COG0247	lactate metabolic process
GWQ43_RS06720	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWQ43_RS06735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS06745	COG0697	spore germination
GWQ43_RS06765	COG3094	Invasion gene expression up-regulator, SirB
GWQ43_RS06775	COG0640	Transcriptional regulator
GWQ43_RS06800	COG0659	secondary active sulfate transmembrane transporter activity
GWQ43_RS06805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_RS06815	COG2314	TM2 domain
GWQ43_RS06820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWQ43_RS06825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWQ43_RS06830	COG0791	NLP P60 protein
GWQ43_RS06850	COG1360	Flagellar Motor Protein
GWQ43_RS06860	COG0835	chemotaxis
GWQ43_RS06865	COG0840	transmembrane signaling receptor activity
GWQ43_RS06870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWQ43_RS06880	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS06885	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWQ43_RS06895	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWQ43_RS06920	COG1815	bacterial-type flagellum-dependent cell motility
GWQ43_RS06925	COG1558	bacterial-type flagellum-dependent cell motility
GWQ43_RS06930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWQ43_RS06970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWQ43_RS06995	COG2176	DNA-directed DNA polymerase activity
GWQ43_RS07005	COG1987	bacterial-type flagellum assembly
GWQ43_RS07020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWQ43_RS07045	COG1157	protein secretion by the type III secretion system
GWQ43_RS07060	COG1766	The M ring may be actively involved in energy transduction
GWQ43_RS07065	COG1677	Flagellar hook-basal body complex protein FliE
GWQ43_RS07070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWQ43_RS07095	COG1334	flagellar protein FlaG
GWQ43_RS07100	COG1191	sigma factor activity
GWQ43_RS07150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_RS07170	COG2733	membrane
GWQ43_RS07175	COG0840	transmembrane signaling receptor activity
GWQ43_RS07180	COG0840	transmembrane signaling receptor activity
GWQ43_RS07205	COG2610	gluconate transmembrane transporter activity
GWQ43_RS07225	COG4974	Belongs to the 'phage' integrase family
GWQ43_RS07265	COG4128	Pfam Zonular occludens toxin
GWQ43_RS07280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_RS07285	COG3657	addiction module killer protein
GWQ43_RS07290	COG4521	taurine ABC transporter
GWQ43_RS07295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_RS07300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS07310	COG0583	DNA-binding transcription factor activity
GWQ43_RS07340	COG2824	Alkylphosphonate utilization operon protein PhnA
GWQ43_RS07355	COG4771	TonB-dependent receptor
GWQ43_RS07360	COG1858	cytochrome C peroxidase
GWQ43_RS07370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS07380	COG1113	amino acid transport
GWQ43_RS07400	COG0583	DNA-binding transcription factor activity
GWQ43_RS07405	COG3755	Protein conserved in bacteria
GWQ43_RS07410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWQ43_RS07450	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_RS07475	COG1278	Cold shock
GWQ43_RS07480	COG0642	Histidine kinase
GWQ43_RS07490	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_RS07500	COG2863	cytochrome
GWQ43_RS07505	COG3258	Cytochrome c
GWQ43_RS07550	COG0025	NhaP-type Na H and K H
GWQ43_RS07565	COG1289	transmembrane transporter activity
GWQ43_RS07570	COG2252	PERMEase
GWQ43_RS07590	COG1999	signal sequence binding
GWQ43_RS07605	COG0069	glutamate synthase activity
GWQ43_RS07615	COG1846	Transcriptional regulator
GWQ43_RS07625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWQ43_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS07675	COG3264	Mechanosensitive ion channel
GWQ43_RS07675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWQ43_RS07680	COG3264	Mechanosensitive ion channel
GWQ43_RS07680	COG1511	domain protein
GWQ43_RS07685	COG0477	Major facilitator Superfamily
GWQ43_RS07700	COG1396	sequence-specific DNA binding
GWQ43_RS07705	COG3437	response regulator, receiver
GWQ43_RS07710	COG0784	Response regulator, receiver
GWQ43_RS07710	COG2205	protein histidine kinase activity
GWQ43_RS07710	COG2198	Histidine kinase
GWQ43_RS07715	COG2239	Acts as a magnesium transporter
GWQ43_RS07725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWQ43_RS07730	COG1490	D-aminoacyl-tRNA deacylase activity
GWQ43_RS07745	COG0456	acetyltransferase
GWQ43_RS07755	COG0501	Belongs to the peptidase M48B family
GWQ43_RS07760	COG2814	Major facilitator Superfamily
GWQ43_RS07770	COG4115	mRNA cleavage
GWQ43_RS07775	COG2161	toxin-antitoxin pair type II binding
GWQ43_RS07905	COG3772	lysozyme
GWQ43_RS07960	COG3706	GGDEF domain
GWQ43_RS07975	COG1522	sequence-specific DNA binding
GWQ43_RS07980	COG0626	cystathionine gamma-synthase activity
GWQ43_RS07990	COG0494	nUDIX hydrolase
GWQ43_RS07995	COG2832	Protein of unknown function (DUF454)
GWQ43_RS08005	COG0137	argininosuccinate synthase activity
GWQ43_RS08010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWQ43_RS08015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_RS08035	COG1609	Transcriptional regulator
GWQ43_RS08045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GWQ43_RS08055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GWQ43_RS08060	COG2205	protein histidine kinase activity
GWQ43_RS08065	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS08070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWQ43_RS08080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_RS08085	COG0268	Binds directly to 16S ribosomal RNA
GWQ43_RS08090	COG0728	peptidoglycan biosynthetic process
GWQ43_RS08100	COG0563	adenylate kinase activity
GWQ43_RS08105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWQ43_RS08110	COG2835	tetraacyldisaccharide 4'-kinase activity
GWQ43_RS08115	COG1663	tetraacyldisaccharide 4'-kinase activity
GWQ43_RS08120	COG0848	biopolymer transport protein
GWQ43_RS08125	COG0811	peptide transport
GWQ43_RS08130	COG1570	exodeoxyribonuclease VII activity
GWQ43_RS08135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWQ43_RS08145	COG0183	Belongs to the thiolase family
GWQ43_RS08155	COG1278	Cold shock
GWQ43_RS08160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWQ43_RS08165	COG0542	response to heat
GWQ43_RS08170	COG2995	paraquat-inducible protein a
GWQ43_RS08175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_RS08175	COG3008	intermembrane lipid transfer
GWQ43_RS08195	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS08235	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWQ43_RS08240	COG0756	dUTP diphosphatase activity
GWQ43_RS08250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWQ43_RS08255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWQ43_RS08260	COG0196	riboflavin kinase activity
GWQ43_RS08265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWQ43_RS08270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWQ43_RS08270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWQ43_RS08280	COG0210	DNA helicase
GWQ43_RS08335	COG0488	(ABC) transporter
GWQ43_RS08340	COG2890	protein-(glutamine-N5) methyltransferase activity
GWQ43_RS08345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWQ43_RS08350	COG2171	N-acyltransferase activity
GWQ43_RS08360	COG2207	Transcriptional regulator
GWQ43_RS08370	COG3273	potassium ion transport
GWQ43_RS08370	COG0471	metal ion transport
GWQ43_RS08420	COG0789	Transcriptional regulator
GWQ43_RS08600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWQ43_RS08660	COG2135	peptidase activity
GWQ43_RS08685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS08690	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWQ43_RS08695	COG0740	serine-type endopeptidase activity
GWQ43_RS08705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWQ43_RS08725	COG0556	nucleotide-excision repair
GWQ43_RS08730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWQ43_RS08740	COG1104	cysteine desulfurase activity
GWQ43_RS08750	COG0316	Belongs to the HesB IscA family
GWQ43_RS08765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWQ43_RS08770	COG4221	oxidoreductase activity
GWQ43_RS08780	COG0840	transmembrane signaling receptor activity
GWQ43_RS08785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWQ43_RS08790	COG0697	spore germination
GWQ43_RS08795	COG0385	Bile acid
GWQ43_RS08805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWQ43_RS08820	COG1136	(ABC) transporter
GWQ43_RS08825	COG0084	hydrolase, TatD family'
GWQ43_RS08840	COG0613	PHP domain protein
GWQ43_RS08850	COG0047	phosphoribosylformylglycinamidine synthase activity
GWQ43_RS08850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWQ43_RS08875	COG0519	Catalyzes the synthesis of GMP from XMP
GWQ43_RS08875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWQ43_RS08910	COG3971	2-oxopent-4-enoate hydratase activity
GWQ43_RS08915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWQ43_RS08930	COG0583	DNA-binding transcription factor activity
GWQ43_RS08945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWQ43_RS08955	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS08960	COG0523	cobalamin synthesis protein
GWQ43_RS08965	COG1469	GTP cyclohydrolase I activity
GWQ43_RS08970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWQ43_RS08980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWQ43_RS08985	COG0735	belongs to the Fur family
GWQ43_RS08990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWQ43_RS09010	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS09015	COG2207	Transcriptional regulator
GWQ43_RS09035	COG0583	DNA-binding transcription factor activity
GWQ43_RS09040	COG1289	transmembrane transporter activity
GWQ43_RS09050	COG1566	PFAM secretion protein HlyD family protein
GWQ43_RS09060	COG1942	4-Oxalocrotonate Tautomerase
GWQ43_RS09075	COG2070	2-Nitropropane dioxygenase
GWQ43_RS09110	COG1309	transcriptional regulator
GWQ43_RS09135	COG0625	glutathione transferase activity
GWQ43_RS09140	COG0740	serine-type endopeptidase activity
GWQ43_RS09190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWQ43_RS09200	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS09230	COG0640	Transcriptional regulator
GWQ43_RS09255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_RS09280	COG3485	protocatechuate 3,4-dioxygenase
GWQ43_RS09290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWQ43_RS09295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWQ43_RS09305	COG3135	benzoate transporter
GWQ43_RS09310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWQ43_RS09315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWQ43_RS09325	COG4555	ABC transporter
GWQ43_RS09335	COG2197	response regulator
GWQ43_RS09340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWQ43_RS09365	COG1846	Transcriptional regulator
GWQ43_RS09370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_RS09375	COG2271	Major facilitator Superfamily
GWQ43_RS09385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWQ43_RS09395	COG0697	spore germination
GWQ43_RS09420	COG3842	ATPase activity
GWQ43_RS09435	COG2205	protein histidine kinase activity
GWQ43_RS09450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWQ43_RS09455	COG0667	Aldo Keto reductase
GWQ43_RS09475	COG2135	peptidase activity
GWQ43_RS09525	COG1272	protein, Hemolysin III
GWQ43_RS09530	COG3422	double-strand break repair
GWQ43_RS09560	COG0765	amino acid transport
GWQ43_RS09565	COG1126	abc transporter atp-binding protein
GWQ43_RS09615	COG2871	sodium ion transport
GWQ43_RS09645	COG2814	Major facilitator Superfamily
GWQ43_RS09650	COG1280	lysine exporter protein (LysE YggA)
GWQ43_RS09670	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_RS09700	COG0330	HflC and HflK could
GWQ43_RS09705	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWQ43_RS09710	COG2226	methyltransferase
GWQ43_RS09720	COG3042	response to heat
GWQ43_RS09730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWQ43_RS09750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWQ43_RS09755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWQ43_RS09770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWQ43_RS09775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWQ43_RS09815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWQ43_RS09820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWQ43_RS09825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWQ43_RS09830	COG0072	phenylalanine-tRNA ligase activity
GWQ43_RS09830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWQ43_RS09845	COG2833	Protein of unknown function (DUF455)
GWQ43_RS09855	COG5265	(ABC) transporter
GWQ43_RS09860	COG1959	2 iron, 2 sulfur cluster binding
GWQ43_RS09865	COG0719	Fe-S assembly protein
GWQ43_RS09870	COG0396	ATPase activity
GWQ43_RS09875	COG0719	Fe-S assembly protein
GWQ43_RS09885	COG0822	iron-sulfur transferase activity
GWQ43_RS09890	COG2151	metal-sulfur cluster biosynthetic enzyme
GWQ43_RS09910	COG1538	Outer membrane efflux protein
GWQ43_RS09950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWQ43_RS09975	COG3436	PFAM IS66 Orf2 family protein
GWQ43_RS10000	COG0747	negative chemotaxis
GWQ43_RS10005	COG0601	transmembrane transport
GWQ43_RS10010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWQ43_RS10015	COG4172	Belongs to the ABC transporter superfamily
GWQ43_RS10025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWQ43_RS10070	COG0604	alcohol dehydrogenase
GWQ43_RS10075	COG2207	Transcriptional regulator
GWQ43_RS10080	COG3048	D-serine ammonia-lyase activity
GWQ43_RS10085	COG3258	Cytochrome c
GWQ43_RS10100	COG3949	Membrane
GWQ43_RS10110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWQ43_RS10125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWQ43_RS10130	COG0569	domain protein
GWQ43_RS10135	COG1902	pentaerythritol trinitrate reductase activity
GWQ43_RS10145	COG1610	YqeY-like protein
GWQ43_RS10150	COG0587	DNA-directed DNA polymerase activity
GWQ43_RS10185	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS10190	COG0583	DNA-binding transcription factor activity
GWQ43_RS10195	COG1686	Belongs to the peptidase S11 family
GWQ43_RS10210	COG1360	Flagellar Motor Protein
GWQ43_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_RS10230	COG4221	oxidoreductase activity
GWQ43_RS10240	COG0307	riboflavin synthase, alpha
GWQ43_RS10255	COG1301	dicarboxylic acid transport
GWQ43_RS10260	COG4191	Histidine kinase
GWQ43_RS10270	COG0583	DNA-binding transcription factor activity
GWQ43_RS10275	COG1053	succinate dehydrogenase
GWQ43_RS10370	COG3300	MHYT domain
GWQ43_RS10370	COG5001	Diguanylate cyclase
GWQ43_RS10435	COG2233	PERMEase
GWQ43_RS10440	COG0071	Belongs to the small heat shock protein (HSP20) family
GWQ43_RS10445	COG1473	amidohydrolase
GWQ43_RS10485	COG2816	NAD+ diphosphatase activity
GWQ43_RS10490	COG1561	YicC-like family, N-terminal region
GWQ43_RS10505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWQ43_RS10510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWQ43_RS10515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWQ43_RS10520	COG0174	glutamine synthetase
GWQ43_RS10525	COG2153	protein acetylation
GWQ43_RS10545	COG3842	ATPase activity
GWQ43_RS10550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_RS10555	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_RS10570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWQ43_RS10580	COG0783	Belongs to the Dps family
GWQ43_RS10590	COG3842	ATPase activity
GWQ43_RS10595	COG0395	ABC-type sugar transport system, permease component
GWQ43_RS10600	COG1175	transmembrane transport
GWQ43_RS10605	COG1653	transport
GWQ43_RS10620	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS10640	COG0625	glutathione transferase activity
GWQ43_RS10650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS10660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWQ43_RS10665	COG0114	fumarate hydratase activity
GWQ43_RS10670	COG2133	pyrroloquinoline quinone binding
GWQ43_RS10675	COG2226	methyltransferase
GWQ43_RS10680	COG0589	response to stress
GWQ43_RS10690	COG2207	Transcriptional regulator
GWQ43_RS10705	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS10710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_RS10715	COG2807	transmembrane transport
GWQ43_RS10725	COG0583	DNA-binding transcription factor activity
GWQ43_RS10755	COG0583	DNA-binding transcription factor activity
GWQ43_RS10760	COG4974	Belongs to the 'phage' integrase family
GWQ43_RS10775	COG2132	Multicopper oxidase
GWQ43_RS10780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWQ43_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS10825	COG3038	cytochrome b561
GWQ43_RS10835	COG2353	YceI-like domain
GWQ43_RS10840	COG1393	Belongs to the ArsC family
GWQ43_RS10845	COG0625	glutathione transferase activity
GWQ43_RS10865	COG0084	hydrolase, TatD family'
GWQ43_RS10870	COG0470	DNA polymerase III
GWQ43_RS10880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWQ43_RS10900	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS10905	COG2914	Belongs to the UPF0125 (RnfH) family
GWQ43_RS10910	COG2867	negative regulation of translational initiation
GWQ43_RS10915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWQ43_RS10920	COG1252	NADH dehydrogenase
GWQ43_RS10945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWQ43_RS10950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWQ43_RS10955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWQ43_RS10965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWQ43_RS10970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWQ43_RS10980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_RS10990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWQ43_RS10995	COG0575	Belongs to the CDS family
GWQ43_RS11000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWQ43_RS11005	COG0233	cytoplasmic translational termination
GWQ43_RS11010	COG0528	UMP kinase activity
GWQ43_RS11015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWQ43_RS11020	COG0052	Belongs to the universal ribosomal protein uS2 family
GWQ43_RS11025	COG0024	Methionine aminopeptidase
GWQ43_RS11030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWQ43_RS11055	COG1286	toxin biosynthetic process
GWQ43_RS11065	COG0285	dihydrofolate synthase activity
GWQ43_RS11070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWQ43_RS11075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWQ43_RS11080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWQ43_RS11095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWQ43_RS11105	COG1999	signal sequence binding
GWQ43_RS11115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWQ43_RS11120	COG0640	Transcriptional regulator
GWQ43_RS11135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS11140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_RS11145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS11150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWQ43_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS11180	COG0183	Belongs to the thiolase family
GWQ43_RS11200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWQ43_RS11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_RS11220	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWQ43_RS11240	COG0183	Belongs to the thiolase family
GWQ43_RS11245	COG0183	Belongs to the thiolase family
GWQ43_RS11255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWQ43_RS11270	COG1982	Orn Lys Arg decarboxylase major
GWQ43_RS11290	COG0194	GDP metabolic process
GWQ43_RS11295	COG1758	RNA polymerase activity
GWQ43_RS11300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWQ43_RS11310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWQ43_RS11315	COG0739	heme binding
GWQ43_RS11320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_RS11325	COG0584	glycerophosphoryl diester phosphodiesterase
GWQ43_RS11330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWQ43_RS11335	COG1187	pseudouridine synthase activity
GWQ43_RS11340	COG3161	chorismate lyase activity
GWQ43_RS11345	COG2814	Major facilitator Superfamily
GWQ43_RS11350	COG0656	L-ascorbic acid biosynthetic process
GWQ43_RS11360	COG0668	transmembrane transport
GWQ43_RS11365	COG0165	Argininosuccinate lyase
GWQ43_RS11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS11395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWQ43_RS11405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWQ43_RS11410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWQ43_RS11415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWQ43_RS11420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWQ43_RS11425	COG2252	PERMEase
GWQ43_RS11430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_RS11450	COG0488	(ABC) transporter
GWQ43_RS11455	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWQ43_RS11465	COG1131	(ABC) transporter
GWQ43_RS11470	COG0842	Transport permease protein
GWQ43_RS11475	COG0840	transmembrane signaling receptor activity
GWQ43_RS11485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWQ43_RS11490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWQ43_RS11495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS11505	COG2022	thiamine diphosphate biosynthetic process
GWQ43_RS11525	COG1414	Transcriptional regulator
GWQ43_RS11535	COG0730	response to heat
GWQ43_RS11545	COG1666	GTP binding
GWQ43_RS11550	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_RS11555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWQ43_RS11560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWQ43_RS11560	COG0519	Catalyzes the synthesis of GMP from XMP
GWQ43_RS11565	COG2207	Transcriptional regulator
GWQ43_RS11575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_RS11580	COG0135	phosphoribosylanthranilate isomerase activity
GWQ43_RS11585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS11595	COG0101	tRNA pseudouridine synthase activity
GWQ43_RS11605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWQ43_RS11630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWQ43_RS11640	COG4566	intracellular signal transduction
GWQ43_RS11655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWQ43_RS11660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWQ43_RS11670	COG1295	ribonuclease BN
GWQ43_RS11680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWQ43_RS11710	COG4964	Belongs to the GSP D family
GWQ43_RS11745	COG3712	iron ion homeostasis
GWQ43_RS11750	COG1595	DNA-templated transcription, initiation
GWQ43_RS11760	COG4774	siderophore transport
GWQ43_RS11765	COG3712	iron ion homeostasis
GWQ43_RS11790	COG2959	enzyme of heme biosynthesis
GWQ43_RS11800	COG0181	hydroxymethylbilane synthase activity
GWQ43_RS11805	COG0861	Integral membrane protein TerC family
GWQ43_RS11810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWQ43_RS11815	COG0045	succinate-CoA ligase (ADP-forming) activity
GWQ43_RS11830	COG0583	DNA-binding transcription factor activity
GWQ43_RS11835	COG2137	regulation of response to DNA damage stimulus
GWQ43_RS11840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWQ43_RS11855	COG0477	Major facilitator Superfamily
GWQ43_RS11870	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_RS11875	COG1024	Enoyl-CoA hydratase
GWQ43_RS11880	COG3162	membrane
GWQ43_RS11895	COG0540	Belongs to the ATCase OTCase family
GWQ43_RS11910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWQ43_RS11925	COG2070	2-Nitropropane dioxygenase
GWQ43_RS11935	COG2111	Na H antiporter
GWQ43_RS11935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWQ43_RS11940	COG1006	Multisubunit Na H antiporter MnhC subunit
GWQ43_RS11945	COG0651	ATP synthesis coupled electron transport
GWQ43_RS11955	COG2212	antiporter activity
GWQ43_RS11970	COG0477	Major facilitator Superfamily
GWQ43_RS11995	COG3158	transport of potassium into the cell
GWQ43_RS12000	COG0642	Histidine kinase
GWQ43_RS12005	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS12025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWQ43_RS12030	COG4208	sulfate ABC transporter
GWQ43_RS12035	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_RS12040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWQ43_RS12055	COG1278	Cold shock
GWQ43_RS12070	COG1648	precorrin-2 dehydrogenase activity
GWQ43_RS12070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_RS12105	COG1648	precorrin-2 dehydrogenase activity
GWQ43_RS12105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_RS12115	COG2010	Cytochrome c
GWQ43_RS12120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS12125	COG0626	cystathionine gamma-synthase activity
GWQ43_RS12130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWQ43_RS12135	COG0557	exoribonuclease II activity
GWQ43_RS12160	COG0765	amino acid transport
GWQ43_RS12165	COG1126	abc transporter atp-binding protein
GWQ43_RS12180	COG1850	ribulose-bisphosphate carboxylase activity
GWQ43_RS12200	COG2375	cellular response to nickel ion
GWQ43_RS12240	COG0583	DNA-binding transcription factor activity
GWQ43_RS12245	COG3842	ATPase activity
GWQ43_RS12250	COG1175	transmembrane transport
GWQ43_RS12255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_RS12260	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_RS12295	COG0412	Dienelactone hydrolase
GWQ43_RS12300	COG3530	Putative quorum-sensing-regulated virulence factor
GWQ43_RS12305	COG0625	glutathione transferase activity
GWQ43_RS12310	COG1741	Belongs to the pirin family
GWQ43_RS12320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_RS12325	COG2814	Major facilitator Superfamily
GWQ43_RS12330	COG2807	transmembrane transport
GWQ43_RS12335	COG2207	Transcriptional regulator
GWQ43_RS12340	COG3135	benzoate transporter
GWQ43_RS12365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_RS12375	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_RS12385	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS12390	COG2205	protein histidine kinase activity
GWQ43_RS12405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWQ43_RS12410	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWQ43_RS12415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWQ43_RS12425	COG0330	HflC and HflK could
GWQ43_RS12430	COG0330	HflC and HflK could
GWQ43_RS12435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWQ43_RS12440	COG1923	regulation of RNA biosynthetic process
GWQ43_RS12450	COG1160	GTP binding
GWQ43_RS12455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_RS12460	COG2976	Protein conserved in bacteria
GWQ43_RS12465	COG0124	histidyl-tRNA synthetase
GWQ43_RS12480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWQ43_RS12485	COG0105	UTP biosynthetic process
GWQ43_RS12500	COG0697	spore germination
GWQ43_RS12505	COG0336	Belongs to the RNA methyltransferase TrmD family
GWQ43_RS12515	COG0228	four-way junction DNA binding
GWQ43_RS12520	COG0425	Belongs to the sulfur carrier protein TusA family
GWQ43_RS12525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWQ43_RS12540	COG2351	hydroxyisourate hydrolase activity
GWQ43_RS12575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWQ43_RS12600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWQ43_RS12605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWQ43_RS12635	COG0601	transmembrane transport
GWQ43_RS12665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWQ43_RS12670	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWQ43_RS12675	COG0542	response to heat
GWQ43_RS12680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWQ43_RS12695	COG0348	domain, Protein
GWQ43_RS12715	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_RS12725	COG2217	Heavy metal translocating P-type atpase
GWQ43_RS12730	COG2224	Isocitrate lyase
GWQ43_RS12735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWQ43_RS12735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWQ43_RS12755	COG1472	Belongs to the glycosyl hydrolase 3 family
GWQ43_RS12760	COG0736	holo-[acyl-carrier-protein] synthase activity
GWQ43_RS12770	COG2050	protein possibly involved in aromatic compounds catabolism
GWQ43_RS12775	COG1024	Enoyl-CoA hydratase
GWQ43_RS12780	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS12785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWQ43_RS12790	COG2151	metal-sulfur cluster biosynthetic enzyme
GWQ43_RS12795	COG3396	Phenylacetate-CoA oxygenase
GWQ43_RS12800	COG3460	Phenylacetate-CoA oxygenase
GWQ43_RS12805	COG3396	Phenylacetate-CoA oxygenase
GWQ43_RS12810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWQ43_RS12815	COG0501	Belongs to the peptidase M48B family
GWQ43_RS12820	COG1162	GTPase activity
GWQ43_RS12830	COG0335	large ribosomal subunit rRNA binding
GWQ43_RS12850	COG0450	alkyl hydroperoxide reductase
GWQ43_RS12855	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS12870	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWQ43_RS12875	COG2951	lytic endotransglycosylase activity
GWQ43_RS12885	COG1555	photosystem II stabilization
GWQ43_RS12885	COG1596	polysaccharide export
GWQ43_RS12890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_RS12895	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWQ43_RS12900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWQ43_RS12920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWQ43_RS12925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWQ43_RS12930	COG0287	Prephenate dehydrogenase
GWQ43_RS12940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWQ43_RS12955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWQ43_RS12975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWQ43_RS12995	COG0753	catalase activity
GWQ43_RS13005	COG4335	DNA alkylation repair
GWQ43_RS13015	COG0436	Aminotransferase
GWQ43_RS13025	COG0251	oxidation-reduction process
GWQ43_RS13030	COG1309	transcriptional regulator
GWQ43_RS13040	COG0488	(ABC) transporter
GWQ43_RS13090	COG0625	glutathione transferase activity
GWQ43_RS13130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWQ43_RS13135	COG0732	type I restriction modification DNA specificity domain
GWQ43_RS13140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWQ43_RS13150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWQ43_RS13155	COG1280	lysine exporter protein (LysE YggA)
GWQ43_RS13175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_RS13185	COG5002	protein histidine kinase activity
GWQ43_RS13190	COG2046	Belongs to the sulfate adenylyltransferase family
GWQ43_RS13195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWQ43_RS13210	COG0840	transmembrane signaling receptor activity
GWQ43_RS13215	COG2119	membrane
GWQ43_RS13230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWQ43_RS13235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWQ43_RS13250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWQ43_RS13255	COG2321	neutral zinc metallopeptidase
GWQ43_RS13270	COG2175	clavaminate synthase activity
GWQ43_RS13275	COG1846	Transcriptional regulator
GWQ43_RS13280	COG0347	Belongs to the P(II) protein family
GWQ43_RS13285	COG0004	ammonium transporteR
GWQ43_RS13290	COG3909	cytochrome
GWQ43_RS13300	COG0625	glutathione transferase activity
GWQ43_RS13310	COG0657	acetylesterase activity
GWQ43_RS13315	COG0730	response to heat
GWQ43_RS13320	COG0482	sulfurtransferase activity
GWQ43_RS13325	COG0277	FAD linked oxidase domain protein
GWQ43_RS13330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWQ43_RS13335	COG2879	small protein
GWQ43_RS13340	COG1966	Carbon starvation protein
GWQ43_RS13345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_RS13350	COG0765	amino acid transport
GWQ43_RS13355	COG0765	amino acid transport
GWQ43_RS13360	COG1126	abc transporter atp-binding protein
GWQ43_RS13365	COG0028	Belongs to the TPP enzyme family
GWQ43_RS13370	COG1012	belongs to the aldehyde dehydrogenase family
GWQ43_RS13375	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GWQ43_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS13390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS13395	COG1116	anion transmembrane transporter activity
GWQ43_RS13410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS13425	COG5285	phytanoyl-CoA dioxygenase
GWQ43_RS13430	COG0662	Cupin 2, conserved barrel domain protein
GWQ43_RS13440	COG0456	acetyltransferase
GWQ43_RS13445	COG1846	Transcriptional regulator
GWQ43_RS13455	COG0312	modulator of DNA gyrase
GWQ43_RS13470	COG0308	aminopeptidase N
GWQ43_RS13475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWQ43_RS13490	COG0473	3-isopropylmalate dehydrogenase activity
GWQ43_RS13500	COG0433	COG0433 Predicted ATPase
GWQ43_RS13505	COG0217	transcriptional regulatory protein
GWQ43_RS13510	COG0151	Belongs to the GarS family
GWQ43_RS13520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWQ43_RS13525	COG0799	negative regulation of ribosome biogenesis
GWQ43_RS13530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWQ43_RS13535	COG0424	maF-like protein
GWQ43_RS13555	COG0023	Translation Initiation Factor
GWQ43_RS13565	COG2084	Dehydrogenase
GWQ43_RS13570	COG0625	glutathione transferase activity
GWQ43_RS13575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWQ43_RS13580	COG1047	Peptidyl-prolyl cis-trans
GWQ43_RS13585	COG2003	Belongs to the UPF0758 family
GWQ43_RS13590	COG1737	Transcriptional regulator
GWQ43_RS13595	COG0477	Major facilitator Superfamily
GWQ43_RS13605	COG2271	Major facilitator Superfamily
GWQ43_RS13620	COG0534	Mate efflux family protein
GWQ43_RS13625	COG4175	Glycine betaine
GWQ43_RS13630	COG4176	ABC-type proline glycine betaine transport system permease component
GWQ43_RS13640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWQ43_RS13645	COG2814	Major facilitator Superfamily
GWQ43_RS13650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWQ43_RS13655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWQ43_RS13660	COG0495	leucyl-tRNA aminoacylation
GWQ43_RS13670	COG1466	dna polymerase III delta subunit
GWQ43_RS13675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWQ43_RS13695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWQ43_RS13705	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWQ43_RS13710	COG0148	phosphopyruvate hydratase activity
GWQ43_RS13720	COG2814	Major facilitator Superfamily
GWQ43_RS13735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWQ43_RS13745	COG0504	CTP synthase activity
GWQ43_RS13775	COG0697	spore germination
GWQ43_RS13780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWQ43_RS13790	COG0791	NLP P60 protein
GWQ43_RS13800	COG0583	DNA-binding transcription factor activity
GWQ43_RS13810	COG0583	DNA-binding transcription factor activity
GWQ43_RS13820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWQ43_RS13835	COG1045	serine acetyltransferase
GWQ43_RS13850	COG1381	Involved in DNA repair and RecF pathway recombination
GWQ43_RS13855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWQ43_RS13860	COG0571	ribonuclease III activity
GWQ43_RS13875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_RS13895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWQ43_RS13900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWQ43_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS13910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWQ43_RS13915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWQ43_RS13925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWQ43_RS13930	COG1399	metal-binding, possibly nucleic acid-binding protein
GWQ43_RS13935	COG0424	maF-like protein
GWQ43_RS13945	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWQ43_RS13950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GWQ43_RS13955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWQ43_RS13960	COG0546	phosphoglycolate phosphatase activity
GWQ43_RS13965	COG0564	pseudouridine synthase activity
GWQ43_RS13970	COG1530	ribonuclease E activity
GWQ43_RS13975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWQ43_RS13980	COG0159	tryptophan synthase activity
GWQ43_RS13985	COG0133	tryptophan synthase activity
GWQ43_RS13990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWQ43_RS14000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWQ43_RS14005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWQ43_RS14015	COG2878	Part of a membrane complex involved in electron transport
GWQ43_RS14020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWQ43_RS14025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWQ43_RS14030	COG3047	cAMP biosynthetic process
GWQ43_RS14055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWQ43_RS14060	COG2917	probably involved in intracellular septation
GWQ43_RS14070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_RS14075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWQ43_RS14085	COG1196	nuclear chromosome segregation
GWQ43_RS14095	COG1573	uracil-dna glycosylase
GWQ43_RS14100	COG1214	PFAM Peptidase M22, glycoprotease
GWQ43_RS14105	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS14110	COG2205	protein histidine kinase activity
GWQ43_RS14115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWQ43_RS14120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWQ43_RS14125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWQ43_RS14130	COG0560	Phosphoserine phosphatase
GWQ43_RS14145	COG1007	ATP synthesis coupled electron transport
GWQ43_RS14160	COG0713	ATP synthesis coupled electron transport
GWQ43_RS14170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_RS14175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWQ43_RS14180	COG1034	ATP synthesis coupled electron transport
GWQ43_RS14195	COG0649	NAD binding
GWQ43_RS14200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_RS14205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_RS14210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWQ43_RS14215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS14230	COG0149	triose-phosphate isomerase activity
GWQ43_RS14235	COG0604	alcohol dehydrogenase
GWQ43_RS14255	COG1185	polyribonucleotide nucleotidyltransferase activity
GWQ43_RS14260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWQ43_RS14265	COG1183	phosphatidylcholine synthase activity
GWQ43_RS14270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWQ43_RS14275	COG0440	acetolactate synthase activity
GWQ43_RS14280	COG0028	Belongs to the TPP enzyme family
GWQ43_RS14285	COG1289	transmembrane transporter activity
GWQ43_RS14290	COG3022	response to hydroperoxide
GWQ43_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS14315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWQ43_RS14320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWQ43_RS14325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWQ43_RS14330	COG1674	ftsk spoiiie
GWQ43_RS14335	COG0492	ferredoxin-NADP+ reductase activity
GWQ43_RS14355	COG0477	Major facilitator Superfamily
GWQ43_RS14375	COG2272	Belongs to the type-B carboxylesterase lipase family
GWQ43_RS14380	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS14395	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS14420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWQ43_RS14440	COG2204	response regulator
GWQ43_RS14480	COG4964	Belongs to the GSP D family
GWQ43_RS14540	COG0612	Peptidase, M16
GWQ43_RS14545	COG0484	heat shock protein binding
GWQ43_RS14550	COG0443	Heat shock 70 kDa protein
GWQ43_RS14555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWQ43_RS14560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWQ43_RS14565	COG1420	regulation of RNA biosynthetic process
GWQ43_RS14575	COG0497	DNA recombination
GWQ43_RS14580	COG0735	belongs to the Fur family
GWQ43_RS14585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWQ43_RS14590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWQ43_RS14615	COG0477	Major facilitator Superfamily
GWQ43_RS14620	COG1301	dicarboxylic acid transport
GWQ43_RS14630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWQ43_RS14665	COG1538	Outer membrane efflux protein
GWQ43_RS14725	COG2814	Major facilitator Superfamily
GWQ43_RS14735	COG0243	molybdopterin cofactor binding
GWQ43_RS14735	COG3383	formate dehydrogenase (NAD+) activity
GWQ43_RS14740	COG0437	4 iron, 4 sulfur cluster binding
GWQ43_RS14745	COG2864	formate dehydrogenase
GWQ43_RS14750	COG3058	Necessary for formate dehydrogenase activity
GWQ43_RS14755	COG2819	hydrolase of the alpha beta superfamily
GWQ43_RS14775	COG1454	alcohol dehydrogenase
GWQ43_RS14810	COG1414	Transcriptional regulator
GWQ43_RS14815	COG0513	Belongs to the DEAD box helicase family
GWQ43_RS14820	COG3657	addiction module killer protein
GWQ43_RS14825	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_RS14830	COG0583	DNA-binding transcription factor activity
GWQ43_RS14835	COG4638	Rieske (2fe-2S)
GWQ43_RS14840	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWQ43_RS14855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWQ43_RS14875	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GWQ43_RS14880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWQ43_RS14885	COG2814	Major facilitator Superfamily
GWQ43_RS14905	COG3121	Chaperone
GWQ43_RS14915	COG2205	protein histidine kinase activity
GWQ43_RS14915	COG0784	Response regulator, receiver
GWQ43_RS14920	COG2205	protein histidine kinase activity
GWQ43_RS14920	COG0784	Response regulator, receiver
GWQ43_RS14925	COG2197	response regulator
GWQ43_RS14930	COG5001	Diguanylate cyclase
GWQ43_RS14930	COG2203	Gaf domain
GWQ43_RS14930	COG3706	GGDEF domain
GWQ43_RS14930	COG4251	negative regulation of phosphorylation
GWQ43_RS14940	COG0154	amidase activity
GWQ43_RS14945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS14950	COG2814	Major facilitator Superfamily
GWQ43_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS14995	COG0842	Transport permease protein
GWQ43_RS15000	COG0842	Transport permease protein
GWQ43_RS15000	COG1129	ABC transporter
GWQ43_RS15005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_RS15015	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWQ43_RS15025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWQ43_RS15030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWQ43_RS15035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_RS15050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_RS15065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWQ43_RS15070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWQ43_RS15080	COG0789	Transcriptional regulator
GWQ43_RS15090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_RS15135	COG3278	Belongs to the heme-copper respiratory oxidase family
GWQ43_RS15140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS15160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWQ43_RS15205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_RS15270	COG0517	IMP dehydrogenase activity
GWQ43_RS15270	COG0516	GMP reductase activity
GWQ43_RS15285	COG1027	Aspartate ammonia-lyase
GWQ43_RS15290	COG1846	Transcriptional regulator
GWQ43_RS15305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWQ43_RS15310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWQ43_RS15325	COG1414	Transcriptional regulator
GWQ43_RS15345	COG0513	Belongs to the DEAD box helicase family
GWQ43_RS15365	COG0429	hydrolase of the alpha beta-hydrolase fold
GWQ43_RS15390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWQ43_RS15400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWQ43_RS15410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWQ43_RS15415	COG0632	four-way junction helicase activity
GWQ43_RS15425	COG2255	four-way junction helicase activity
GWQ43_RS15435	COG0418	dihydroorotase activity
GWQ43_RS15445	COG0415	Belongs to the DNA photolyase family
GWQ43_RS15500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWQ43_RS15505	COG4654	Cytochrome c, class I
GWQ43_RS15545	COG1177	transmembrane transport
GWQ43_RS15550	COG3842	ATPase activity
GWQ43_RS15555	COG1840	ABC-type Fe3 transport system, periplasmic component
GWQ43_RS15560	COG2084	Dehydrogenase
GWQ43_RS15575	COG0494	nUDIX hydrolase
GWQ43_RS15580	COG0442	prolyl-tRNA aminoacylation
GWQ43_RS15585	COG0824	Thioesterase
GWQ43_RS15590	COG0811	peptide transport
GWQ43_RS15605	COG0823	Involved in the tonB-independent uptake of proteins
GWQ43_RS15620	COG0596	Alpha beta hydrolase
GWQ43_RS15655	COG1129	ABC transporter
GWQ43_RS15675	COG0427	acetyl-CoA hydrolase
GWQ43_RS15680	COG0583	DNA-binding transcription factor activity
GWQ43_RS15685	COG3634	alkyl hydroperoxide reductase activity
GWQ43_RS15700	COG0697	spore germination
GWQ43_RS15705	COG0175	sulfate reduction
GWQ43_RS15720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWQ43_RS15735	COG0583	DNA-binding transcription factor activity
GWQ43_RS15740	COG1741	Belongs to the pirin family
GWQ43_RS15745	COG3706	GGDEF domain
GWQ43_RS15750	COG0154	amidase activity
GWQ43_RS15760	COG3712	iron ion homeostasis
GWQ43_RS15765	COG1595	DNA-templated transcription, initiation
GWQ43_RS15775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWQ43_RS15785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWQ43_RS15790	COG0284	orotidine-5'-phosphate decarboxylase activity
GWQ43_RS15805	COG1414	Transcriptional regulator
GWQ43_RS15815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWQ43_RS15825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWQ43_RS15830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWQ43_RS15855	COG0742	ribosomal rna small subunit methyltransferase
GWQ43_RS15860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWQ43_RS15865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWQ43_RS15895	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GWQ43_RS15910	COG1335	isochorismatase
GWQ43_RS15915	COG2309	aminopeptidase activity
GWQ43_RS15920	COG0596	Alpha beta hydrolase
GWQ43_RS15925	COG2010	Cytochrome c
GWQ43_RS15925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_RS15930	COG2080	2 iron, 2 sulfur cluster binding
GWQ43_RS15935	COG2010	Cytochrome c
GWQ43_RS15935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWQ43_RS15945	COG0410	ABC transporter
GWQ43_RS15950	COG0411	ABC transporter
GWQ43_RS15975	COG3706	GGDEF domain
GWQ43_RS15990	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS16005	COG1234	tRNA 3'-trailer cleavage
GWQ43_RS16010	COG2188	Transcriptional regulator
GWQ43_RS16020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWQ43_RS16030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWQ43_RS16030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWQ43_RS16035	COG3608	succinylglutamate desuccinylase aspartoacylase
GWQ43_RS16035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWQ43_RS16040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWQ43_RS16050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWQ43_RS16080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS16105	COG1335	isochorismatase
GWQ43_RS16110	COG2309	aminopeptidase activity
GWQ43_RS16115	COG0596	Alpha beta hydrolase
GWQ43_RS16130	COG1120	ATPase activity
GWQ43_RS16145	COG4206	TonB-dependent receptor
GWQ43_RS16150	COG2031	fatty acid transporter
GWQ43_RS16155	COG0583	DNA-binding transcription factor activity
GWQ43_RS16160	COG0402	S-adenosylhomocysteine deaminase activity
GWQ43_RS16165	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS16180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWQ43_RS16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWQ43_RS16190	COG0328	RNA-DNA hybrid ribonuclease activity
GWQ43_RS16195	COG2226	methyltransferase
GWQ43_RS16200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWQ43_RS16205	COG1388	LysM domain
GWQ43_RS16205	COG0741	lytic transglycosylase activity
GWQ43_RS16215	COG2204	response regulator
GWQ43_RS16220	COG4191	Histidine kinase
GWQ43_RS16225	COG1301	dicarboxylic acid transport
GWQ43_RS16260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWQ43_RS16265	COG2204	response regulator
GWQ43_RS16280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GWQ43_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS16300	COG1877	trehalose-phosphatase activity
GWQ43_RS16335	COG0604	alcohol dehydrogenase
GWQ43_RS16345	COG1024	Enoyl-CoA hydratase
GWQ43_RS16365	COG1902	pentaerythritol trinitrate reductase activity
GWQ43_RS16390	COG0583	DNA-binding transcription factor activity
GWQ43_RS16395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWQ43_RS16400	COG1454	alcohol dehydrogenase
GWQ43_RS16420	COG0583	DNA-binding transcription factor activity
GWQ43_RS16460	COG1393	Belongs to the ArsC family
GWQ43_RS16465	COG0431	NADPH-dependent FMN reductase
GWQ43_RS16470	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS16475	COG0642	Histidine kinase
GWQ43_RS16490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWQ43_RS16490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWQ43_RS16495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWQ43_RS16500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWQ43_RS16505	COG1881	PFAM PEBP family protein
GWQ43_RS16510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWQ43_RS16515	COG0739	heme binding
GWQ43_RS16520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWQ43_RS16525	COG0316	Belongs to the HesB IscA family
GWQ43_RS16535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWQ43_RS16540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWQ43_RS16545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWQ43_RS16550	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS16555	COG0312	modulator of DNA gyrase
GWQ43_RS16560	COG3028	Belongs to the UPF0307 family
GWQ43_RS16590	COG4566	intracellular signal transduction
GWQ43_RS16595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWQ43_RS16600	COG4681	YaeQ
GWQ43_RS16625	COG0762	integral membrane protein
GWQ43_RS16630	COG2169	Transcriptional regulator
GWQ43_RS16630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWQ43_RS16640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWQ43_RS16655	COG0439	Biotin carboxylase
GWQ43_RS16660	COG0511	ligase activity, forming carbon-carbon bonds
GWQ43_RS16665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWQ43_RS16670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWQ43_RS16675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWQ43_RS16680	COG3150	esterase
GWQ43_RS16695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWQ43_RS16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWQ43_RS16710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWQ43_RS16725	COG1678	Uncharacterized ACR, COG1678
GWQ43_RS16740	COG0352	thiamine-phosphate diphosphorylase activity
GWQ43_RS16745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWQ43_RS16760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWQ43_RS16770	COG3237	CsbD-like
GWQ43_RS16775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWQ43_RS16780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWQ43_RS16785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWQ43_RS16790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GWQ43_RS16815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWQ43_RS16830	COG1126	abc transporter atp-binding protein
GWQ43_RS16835	COG0765	amino acid transport
GWQ43_RS16840	COG4597	amino acid ABC transporter
GWQ43_RS16845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWQ43_RS16850	COG2884	Cell division ATP-binding protein ftsE
GWQ43_RS16855	COG2177	Part of the ABC transporter FtsEX involved in
GWQ43_RS16865	COG0772	Belongs to the SEDS family
GWQ43_RS16870	COG0768	penicillin binding
GWQ43_RS16880	COG1792	Involved in formation and maintenance of cell shape
GWQ43_RS16885	COG1077	Cell shape determining protein MreB Mrl
GWQ43_RS16890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWQ43_RS16895	COG0154	amidase activity
GWQ43_RS16900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWQ43_RS16905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWQ43_RS16910	COG0583	DNA-binding transcription factor activity
GWQ43_RS16915	COG2259	Doxx family
GWQ43_RS16920	COG3384	dioxygenase
GWQ43_RS16930	COG3245	cytochrome
GWQ43_RS16945	COG3604	Transcriptional regulator
GWQ43_RS16960	COG0786	glutamate:sodium symporter activity
GWQ43_RS16965	COG0142	geranyltranstransferase activity
GWQ43_RS16975	COG0494	nUDIX hydrolase
GWQ43_RS16980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWQ43_RS17005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWQ43_RS17010	COG0237	dephospho-CoA kinase activity
GWQ43_RS17025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWQ43_RS17030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWQ43_RS17040	COG0477	Major facilitator Superfamily
GWQ43_RS17055	COG4206	TonB-dependent receptor
GWQ43_RS17060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWQ43_RS17075	COG1595	DNA-templated transcription, initiation
GWQ43_RS17085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWQ43_RS17105	COG0598	Magnesium transport protein CorA
GWQ43_RS17120	COG2022	thiamine diphosphate biosynthetic process
GWQ43_RS17125	COG0351	phosphomethylpyrimidine kinase
GWQ43_RS17130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWQ43_RS17135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWQ43_RS17140	COG1538	Outer membrane efflux protein
GWQ43_RS17145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWQ43_RS17155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWQ43_RS17170	COG2226	methyltransferase
GWQ43_RS17175	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS17190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GWQ43_RS17195	COG1984	allophanate hydrolase subunit 2
GWQ43_RS17200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWQ43_RS17205	COG1238	metal cluster binding
GWQ43_RS17230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWQ43_RS17235	COG4988	ABC transporter
GWQ43_RS17245	COG1294	oxidase, subunit
GWQ43_RS17250	COG1271	oxidase subunit
GWQ43_RS17265	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWQ43_RS17280	COG1137	ATPase activity
GWQ43_RS17290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWQ43_RS17295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWQ43_RS17300	COG1660	Displays ATPase and GTPase activities
GWQ43_RS17310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWQ43_RS17315	COG0792	nuclease activity
GWQ43_RS17320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWQ43_RS17335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWQ43_RS17355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWQ43_RS17360	COG0793	Belongs to the peptidase S41A family
GWQ43_RS17370	COG0588	phosphoglycerate mutase activity
GWQ43_RS17375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWQ43_RS17385	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWQ43_RS17390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWQ43_RS17395	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS17400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWQ43_RS17405	COG1040	competence protein
GWQ43_RS17410	COG2226	methyltransferase
GWQ43_RS17415	COG4771	TonB-dependent receptor
GWQ43_RS17420	COG0745	RESPONSE REGULATOR receiver
GWQ43_RS17435	COG2204	response regulator
GWQ43_RS17455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWQ43_RS17470	COG3473	Maleate cis-trans isomerase
GWQ43_RS17485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWQ43_RS17515	COG0662	Cupin 2, conserved barrel domain protein
GWQ43_RS17515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GWQ43_RS17520	COG1215	transferase activity, transferring glycosyl groups
GWQ43_RS17530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWQ43_RS17550	COG1088	dTDP-glucose 4,6-dehydratase activity
GWQ43_RS17555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWQ43_RS17570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWQ43_RS17580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWQ43_RS17585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWQ43_RS17590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWQ43_RS17605	COG0356	it plays a direct role in the translocation of protons across the membrane
GWQ43_RS17615	COG1024	Enoyl-CoA hydratase
GWQ43_RS17630	COG0037	tRNA processing
GWQ43_RS17635	COG0163	prenyltransferase activity
GWQ43_RS17640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWQ43_RS17645	COG2890	protein-(glutamine-N5) methyltransferase activity
GWQ43_RS17695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWQ43_RS17725	COG0811	peptide transport
GWQ43_RS17740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWQ43_RS17745	COG2264	protein methyltransferase activity
GWQ43_RS17750	COG4773	Receptor
GWQ43_RS17770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWQ43_RS17795	COG3180	Ammonia monooxygenase
GWQ43_RS17815	COG5002	protein histidine kinase activity
GWQ43_RS17830	COG0477	Major facilitator Superfamily
GWQ43_RS17835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_RS17855	COG1116	anion transmembrane transporter activity
GWQ43_RS17885	COG0437	4 iron, 4 sulfur cluster binding
GWQ43_RS17890	COG2864	formate dehydrogenase
GWQ43_RS17900	COG1921	L-seryl-tRNASec selenium transferase activity
GWQ43_RS17905	COG3276	selenocysteine insertion sequence binding
GWQ43_RS17915	COG1476	TRANSCRIPTIONal
GWQ43_RS17920	COG0235	Class ii aldolase
GWQ43_RS17930	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS17940	COG4771	TonB-dependent receptor
GWQ43_RS17955	COG0709	Synthesizes selenophosphate from selenide and ATP
GWQ43_RS17970	COG0583	DNA-binding transcription factor activity
GWQ43_RS17975	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWQ43_RS17980	COG3901	Regulator of nitric oxide reductase transcription
GWQ43_RS17980	COG0348	domain, Protein
GWQ43_RS17985	COG4263	nitrous-oxide reductase activity
GWQ43_RS18000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWQ43_RS18015	COG0166	Belongs to the GPI family
GWQ43_RS18035	COG1215	transferase activity, transferring glycosyl groups
GWQ43_RS18075	COG0438	transferase activity, transferring glycosyl groups
GWQ43_RS18085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWQ43_RS18120	COG0156	8-amino-7-oxononanoate synthase activity
GWQ43_RS18125	COG3321	synthase
GWQ43_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS18125	COG0604	alcohol dehydrogenase
GWQ43_RS18130	COG2233	PERMEase
GWQ43_RS18135	COG0697	spore germination
GWQ43_RS18140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS18145	COG0697	spore germination
GWQ43_RS18170	COG2885	chlorophyll binding
GWQ43_RS18255	COG3501	Rhs element vgr protein
GWQ43_RS18265	COG0183	Belongs to the thiolase family
GWQ43_RS18270	COG1024	Enoyl-CoA hydratase
GWQ43_RS18270	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWQ43_RS18285	COG1127	ABC transporter
GWQ43_RS18290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWQ43_RS18295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWQ43_RS18310	COG1131	(ABC) transporter
GWQ43_RS18315	COG0842	Transport permease protein
GWQ43_RS18325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWQ43_RS18335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWQ43_RS18340	COG0131	Imidazoleglycerol-phosphate dehydratase
GWQ43_RS18350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWQ43_RS18355	COG0107	imidazoleglycerol-phosphate synthase activity
GWQ43_RS18365	COG0140	phosphoribosyl-ATP diphosphatase activity
GWQ43_RS18370	COG0537	adenosine 5'-monophosphoramidase activity
GWQ43_RS18375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWQ43_RS18380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWQ43_RS18390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_RS18400	COG1970	mechanosensitive ion channel activity
GWQ43_RS18405	COG0723	plastoquinol--plastocyanin reductase activity
GWQ43_RS18410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWQ43_RS18415	COG2857	Cytochrome c1
GWQ43_RS18420	COG0625	glutathione transferase activity
GWQ43_RS18425	COG2969	positive regulation of protein catabolic process
GWQ43_RS18430	COG4208	sulfate ABC transporter
GWQ43_RS18435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWQ43_RS18440	COG4150	thiosulfate binding
GWQ43_RS18460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWQ43_RS18480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GWQ43_RS18485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWQ43_RS18500	COG0129	dihydroxy-acid dehydratase activity
GWQ43_RS18505	COG1802	Transcriptional regulator
GWQ43_RS18510	COG1522	sequence-specific DNA binding
GWQ43_RS18520	COG3483	tryptophan 2,3-dioxygenase activity
GWQ43_RS18540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWQ43_RS18545	COG0656	L-ascorbic acid biosynthetic process
GWQ43_RS18555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWQ43_RS18565	COG2226	methyltransferase
GWQ43_RS18575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWQ43_RS18590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GWQ43_RS18595	COG0583	DNA-binding transcription factor activity
GWQ43_RS18600	COG0477	Major facilitator Superfamily
GWQ43_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
GWQ43_RS18615	COG1335	isochorismatase
GWQ43_RS18620	COG1335	isochorismatase
GWQ43_RS18640	COG2823	Periplasmic or secreted lipoprotein
GWQ43_RS18650	COG3284	Transcriptional regulator
GWQ43_RS18665	COG4774	siderophore transport
GWQ43_RS18695	COG1595	DNA-templated transcription, initiation
GWQ43_RS18705	COG1522	sequence-specific DNA binding
GWQ43_RS18715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWQ43_RS18735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWQ43_RS18770	COG0109	protoheme IX farnesyltransferase activity
GWQ43_RS18790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWQ43_RS18810	COG3568	Endonuclease Exonuclease Phosphatase
GWQ43_RS18815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWQ43_RS18840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWQ43_RS18850	COG1228	amidohydrolase
GWQ43_RS18870	COG2986	histidine ammonia-lyase
GWQ43_RS18875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWQ43_RS18905	COG2814	Major facilitator Superfamily
GWQ43_RS18915	COG0789	Transcriptional regulator
GWQ43_RS18935	COG0625	glutathione transferase activity
GWQ43_RS18965	COG2365	Tyrosine phosphatase family
GWQ43_RS18970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWQ43_RS18990	COG2423	ornithine cyclodeaminase activity
GWQ43_RS19040	COG3069	C4-dicarboxylate transmembrane transporter activity
GWQ43_RS19050	COG1802	Transcriptional regulator
GWQ43_RS19060	COG2814	Major facilitator Superfamily
GWQ43_RS19075	COG2814	Major facilitator Superfamily
GWQ43_RS19080	COG0251	oxidation-reduction process
GWQ43_RS19085	COG3181	Tripartite tricarboxylate transporter family receptor
GWQ43_RS19090	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWQ43_RS19095	COG2186	Transcriptional regulator
GWQ43_RS19100	COG1595	DNA-templated transcription, initiation
GWQ43_RS19105	COG3712	iron ion homeostasis
GWQ43_RS19120	COG2814	Major facilitator Superfamily
GWQ43_RS19130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GWQ43_RS19135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWQ43_RS19140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWQ43_RS19160	COG5002	protein histidine kinase activity
GWQ43_RS19160	COG5001	Diguanylate cyclase
GWQ43_RS19165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWQ43_RS19170	COG1333	cytochrome c biogenesis protein
GWQ43_RS19180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWQ43_RS19185	COG0113	porphobilinogen synthase activity
GWQ43_RS19190	COG4232	protein-disulfide reductase activity
GWQ43_RS19210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWQ43_RS19215	COG0203	ribosomal protein L17
GWQ43_RS19220	COG0202	RNA polymerase activity
GWQ43_RS19225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWQ43_RS19230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWQ43_RS19235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWQ43_RS19240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWQ43_RS19250	COG0201	protein transport
GWQ43_RS19255	COG0200	Binds to the 23S rRNA
GWQ43_RS19260	COG1841	ribosomal large subunit assembly
GWQ43_RS19265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWQ43_RS19270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWQ43_RS19275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWQ43_RS19280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWQ43_RS19285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWQ43_RS19290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWQ43_RS19295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWQ43_RS19300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWQ43_RS19340	COG1538	Outer membrane efflux protein
GWQ43_RS19355	COG1960	acyl-CoA dehydrogenase activity
GWQ43_RS19360	COG0183	Belongs to the thiolase family
GWQ43_RS19370	COG2067	long-chain fatty acid transport protein
GWQ43_RS19385	COG0318	PFAM AMP-dependent synthetase and ligase
GWQ43_RS19390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWQ43_RS19395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWQ43_RS19400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWQ43_RS19400	COG1648	precorrin-2 dehydrogenase activity
GWQ43_RS19415	COG1116	anion transmembrane transporter activity
GWQ43_RS19435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWQ43_RS19440	COG0255	Belongs to the universal ribosomal protein uL29 family
GWQ43_RS19445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWQ43_RS19450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWQ43_RS19455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWQ43_RS19460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWQ43_RS19465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWQ43_RS19470	COG0089	rRNA binding
GWQ43_RS19475	COG0088	Forms part of the polypeptide exit tunnel
GWQ43_RS19480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWQ43_RS19485	COG4175	Glycine betaine
GWQ43_RS19490	COG4176	ABC-type proline glycine betaine transport system permease component
GWQ43_RS19495	COG0051	transcription antitermination factor activity, RNA binding
GWQ43_RS19500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWQ43_RS19505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWQ43_RS19510	COG0049	tRNA binding
GWQ43_RS19515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWQ43_RS19545	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWQ43_RS19550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWQ43_RS19555	COG0085	RNA polymerase activity
GWQ43_RS19560	COG0222	ribosome binding
GWQ43_RS19565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWQ43_RS19570	COG0081	regulation of translation
GWQ43_RS19595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWQ43_RS19615	COG1475	DNA binding
GWQ43_RS19620	COG1192	Involved in chromosome partitioning
GWQ43_RS19625	COG0357	Ribosomal RNA small subunit methyltransferase G
GWQ43_RS19630	COG0445	tRNA wobble uridine modification
GWQ43_RS19635	COG0436	Aminotransferase
GWQ43_RS19645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWQ43_RS19650	COG3706	GGDEF domain
GWQ43_RS19655	COG0688	phosphatidylethanolamine metabolic process
GWQ43_RS19665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWQ43_RS19710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWQ43_RS19745	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWQ43_RS19765	COG0596	Alpha beta hydrolase
GWQ43_RS19770	COG2309	aminopeptidase activity
GWQ43_RS19775	COG1335	isochorismatase
GWQ43_RS19800	COG0753	catalase activity
GWQ43_RS19805	COG0706	membrane insertase activity
GWQ43_RS19810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWQ43_RS19815	COG0594	ribonuclease P activity
GWQ43_RS19820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWQ43_RS19945	COG0616	signal peptide processing
GWQ43_RS20130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWQ43_RS20195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWQ43_RS20200	COG0798	PFAM Bile acid sodium symporter
GWQ43_RS20225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWQ43_RS20240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWQ43_RS20290	COG1192	Involved in chromosome partitioning
GWQ43_RS20335	COG3300	MHYT domain
GWQ43_RS20335	COG5001	Diguanylate cyclase
GWQ43_RS20385	COG3173	Aminoglycoside phosphotransferase
GWQ43_RS20395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWQ43_RS20435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs