locus-tag	class	description
M2J83_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2J83_RS00010	COG0592	DNA-directed DNA polymerase activity
M2J83_RS00020	COG1187	pseudouridine synthase activity
M2J83_RS00035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS00065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_RS00085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS00105	COG2070	2-Nitropropane dioxygenase
M2J83_RS00115	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS00125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS00145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M2J83_RS00170	COG0583	DNA-binding transcription factor activity
M2J83_RS00180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS00190	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS00205	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS00215	COG0596	Alpha beta hydrolase
M2J83_RS00215	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS00235	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS00245	COG0697	spore germination
M2J83_RS00250	COG0583	DNA-binding transcription factor activity
M2J83_RS00260	COG3842	ATPase activity
M2J83_RS00270	COG0436	Aminotransferase
M2J83_RS00280	COG0523	cobalamin synthesis protein
M2J83_RS00335	COG1846	Transcriptional regulator
M2J83_RS00355	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_RS00360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_RS00365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M2J83_RS00375	COG4638	Rieske (2fe-2S)
M2J83_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS00450	COG2207	Transcriptional regulator
M2J83_RS00485	COG1595	DNA-templated transcription, initiation
M2J83_RS00490	COG4608	Belongs to the ABC transporter superfamily
M2J83_RS00495	COG0444	Belongs to the ABC transporter superfamily
M2J83_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_RS00505	COG0601	transmembrane transport
M2J83_RS00515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2J83_RS00525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M2J83_RS00530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_RS00535	COG0431	NADPH-dependent FMN reductase
M2J83_RS00560	COG0583	DNA-binding transcription factor activity
M2J83_RS00570	COG4149	molybdate abc transporter
M2J83_RS00585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M2J83_RS00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2J83_RS00600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS00620	COG0028	Belongs to the TPP enzyme family
M2J83_RS00625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS00655	COG2922	Belongs to the Smg family
M2J83_RS00670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M2J83_RS00675	COG0183	Belongs to the thiolase family
M2J83_RS00680	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M2J83_RS00685	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS00705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_RS00715	COG0018	arginyl-trna synthetase
M2J83_RS00735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_RS00750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2J83_RS00755	COG4774	siderophore transport
M2J83_RS00760	COG0066	3-isopropylmalate dehydratase activity
M2J83_RS00765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M2J83_RS00770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_RS00775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS00780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS00780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_RS00790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS00795	COG1335	isochorismatase
M2J83_RS00800	COG0583	DNA-binding transcription factor activity
M2J83_RS00820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2J83_RS00825	COG1280	lysine exporter protein (LysE YggA)
M2J83_RS00830	COG0513	Belongs to the DEAD box helicase family
M2J83_RS00840	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M2J83_RS00855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2J83_RS00870	COG0154	amidase activity
M2J83_RS00885	COG0583	DNA-binding transcription factor activity
M2J83_RS00915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M2J83_RS00920	COG1127	ABC transporter
M2J83_RS00925	COG3218	ABC-type transport auxiliary lipoprotein component
M2J83_RS00925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_RS00940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2J83_RS00945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS00955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS00985	COG0583	DNA-binding transcription factor activity
M2J83_RS01010	COG4680	protein conserved in bacteria
M2J83_RS01030	COG2358	TRAP transporter, solute receptor (TAXI family
M2J83_RS01040	COG0564	pseudouridine synthase activity
M2J83_RS01045	COG0252	asparaginase activity
M2J83_RS01070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2J83_RS01075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2J83_RS01080	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS01100	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS01125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS01140	COG0758	DNA mediated transformation
M2J83_RS01145	COG0242	peptide deformylase activity
M2J83_RS01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2J83_RS01155	COG0697	spore germination
M2J83_RS01170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS01185	COG4336	lyase activity
M2J83_RS01190	COG0583	DNA-binding transcription factor activity
M2J83_RS01195	COG0859	PFAM glycosyl transferase family 9
M2J83_RS01205	COG1278	Cold shock
M2J83_RS01210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2J83_RS01215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M2J83_RS01220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M2J83_RS01220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M2J83_RS01230	COG1686	Belongs to the peptidase S11 family
M2J83_RS01240	COG2921	Belongs to the UPF0250 family
M2J83_RS01245	COG0321	lipoyl(octanoyl) transferase activity
M2J83_RS01265	COG1024	Enoyl-CoA hydratase
M2J83_RS01270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M2J83_RS01280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2J83_RS01325	COG0826	peptidase U32
M2J83_RS01335	COG3154	lipid carrier protein
M2J83_RS01360	COG0134	indole-3-glycerol-phosphate synthase activity
M2J83_RS01365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M2J83_RS01370	COG0512	Glutamine amidotransferase of anthranilate synthase
M2J83_RS01380	COG0546	phosphoglycolate phosphatase activity
M2J83_RS01390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2J83_RS01395	COG2967	ApaG domain
M2J83_RS01400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M2J83_RS01405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS01410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_RS01420	COG0840	transmembrane signaling receptor activity
M2J83_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS01435	COG1535	isochorismatase
M2J83_RS01435	COG3433	isochorismatase activity
M2J83_RS01440	COG1169	isochorismate synthase
M2J83_RS01455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M2J83_RS01455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M2J83_RS01460	COG3433	isochorismatase activity
M2J83_RS01460	COG1535	isochorismatase
M2J83_RS01465	COG1021	2,3-dihydroxybenzoate-AMP ligase
M2J83_RS01495	COG0683	leucine binding
M2J83_RS01510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS01545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M2J83_RS01550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_RS01555	COG2819	hydrolase of the alpha beta superfamily
M2J83_RS01560	COG0513	Belongs to the DEAD box helicase family
M2J83_RS01565	COG2814	Major facilitator Superfamily
M2J83_RS01575	COG0583	DNA-binding transcription factor activity
M2J83_RS01585	COG1253	flavin adenine dinucleotide binding
M2J83_RS01620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2J83_RS01630	COG2311	Membrane
M2J83_RS01670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2J83_RS01690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS01695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_RS01705	COG0583	DNA-binding transcription factor activity
M2J83_RS01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS01720	COG0765	amino acid transport
M2J83_RS01725	COG0765	amino acid transport
M2J83_RS01730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_RS01735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_RS01750	COG3391	amine dehydrogenase activity
M2J83_RS01760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M2J83_RS01785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M2J83_RS01790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2J83_RS01795	COG0210	DNA helicase
M2J83_RS01810	COG0070	glutamate synthase
M2J83_RS01810	COG0067	glutamate synthase
M2J83_RS01810	COG0069	glutamate synthase activity
M2J83_RS01815	COG1024	Enoyl-CoA hydratase
M2J83_RS01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS01830	COG1250	3-hydroxyacyl-CoA dehydrogenase
M2J83_RS01860	COG2918	glutathione biosynthetic process
M2J83_RS01870	COG2197	response regulator
M2J83_RS01875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M2J83_RS01885	COG2223	nitrite transmembrane transporter activity
M2J83_RS01890	COG2860	membrane
M2J83_RS01895	COG1346	cytolysis
M2J83_RS01910	COG0251	oxidation-reduction process
M2J83_RS01925	COG5295	Hep Hag repeat protein
M2J83_RS01945	COG1280	lysine exporter protein (LysE YggA)
M2J83_RS01975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M2J83_RS01990	COG2096	Adenosyltransferase
M2J83_RS02005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2J83_RS02010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2J83_RS02020	COG0523	cobalamin synthesis protein
M2J83_RS02025	COG0735	belongs to the Fur family
M2J83_RS02040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2J83_RS02045	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2J83_RS02050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M2J83_RS02060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M2J83_RS02065	COG1560	Kdo2-lipid A biosynthetic process
M2J83_RS02075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2J83_RS02080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M2J83_RS02085	COG1950	PFAM Membrane protein of
M2J83_RS02120	COG0275	rRNA processing
M2J83_RS02125	COG0730	response to heat
M2J83_RS02130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M2J83_RS02135	COG0129	dihydroxy-acid dehydratase activity
M2J83_RS02140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2J83_RS02160	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS02170	COG0628	permease
M2J83_RS02215	COG3846	protein secretion by the type IV secretion system
M2J83_RS02225	COG3451	type IV secretory pathway VirB4
M2J83_RS02235	COG3838	Conjugal transfer protein Trbc
M2J83_RS02240	COG4962	Type ii secretion system protein e
M2J83_RS02260	COG0583	DNA-binding transcription factor activity
M2J83_RS02270	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2J83_RS02275	COG0640	Transcriptional regulator
M2J83_RS02290	COG4959	Type IV secretory pathway protease TraF
M2J83_RS02305	COG1192	Involved in chromosome partitioning
M2J83_RS02335	COG5489	Protein of unknown function (DUF736)
M2J83_RS02360	COG2003	Belongs to the UPF0758 family
M2J83_RS02370	COG3621	Patatin-like phospholipase
M2J83_RS02430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS02470	COG1021	2,3-dihydroxybenzoate-AMP ligase
M2J83_RS02485	COG2814	Major facilitator Superfamily
M2J83_RS02505	COG1846	Transcriptional regulator
M2J83_RS02520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_RS02530	COG0789	Transcriptional regulator
M2J83_RS02540	COG4774	siderophore transport
M2J83_RS02545	COG4607	ABC-type enterochelin transport system periplasmic component
M2J83_RS02550	COG4604	ABC transporter, ATP-binding protein
M2J83_RS02555	COG4605	iron ion homeostasis
M2J83_RS02560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_RS02565	COG1132	(ABC) transporter
M2J83_RS02570	COG1132	(ABC) transporter
M2J83_RS02570	COG2375	cellular response to nickel ion
M2J83_RS02575	COG0277	FAD linked oxidase domain protein
M2J83_RS02580	COG1304	FMN binding
M2J83_RS02585	COG2186	Transcriptional regulator
M2J83_RS02605	COG2188	Transcriptional regulator
M2J83_RS02610	COG1522	sequence-specific DNA binding
M2J83_RS02615	COG3844	kynureninase activity
M2J83_RS02620	COG1113	amino acid transport
M2J83_RS02650	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS02655	COG1349	DNA-binding transcription factor activity
M2J83_RS02660	COG3842	ATPase activity
M2J83_RS02675	COG0395	ABC-type sugar transport system, permease component
M2J83_RS02700	COG0861	Integral membrane protein TerC family
M2J83_RS02705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_RS02715	COG1671	Belongs to the UPF0178 family
M2J83_RS02725	COG1418	mRNA catabolic process
M2J83_RS02735	COG4948	Mandelate Racemase Muconate Lactonizing
M2J83_RS02745	COG0477	Major facilitator Superfamily
M2J83_RS02760	COG0154	amidase activity
M2J83_RS02770	COG0583	DNA-binding transcription factor activity
M2J83_RS02795	COG0326	Molecular chaperone. Has ATPase activity
M2J83_RS02800	COG4774	siderophore transport
M2J83_RS02805	COG3128	pkhd-type hydroxylase
M2J83_RS02830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2J83_RS02835	COG1652	LysM domain
M2J83_RS02850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2J83_RS02860	COG0582	viral genome integration into host DNA
M2J83_RS02910	COG0629	single-stranded DNA binding
M2J83_RS02915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2J83_RS03110	COG2003	Belongs to the UPF0758 family
M2J83_RS03200	COG0433	COG0433 Predicted ATPase
M2J83_RS03200	COG1674	ftsk spoiiie
M2J83_RS03260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_RS03265	COG3842	ATPase activity
M2J83_RS03280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_RS03300	COG0789	Transcriptional regulator
M2J83_RS03310	COG2608	mercury ion transmembrane transporter activity
M2J83_RS03315	COG2608	mercury ion transmembrane transporter activity
M2J83_RS03320	COG0789	Transcriptional regulator
M2J83_RS03330	COG1120	ATPase activity
M2J83_RS03345	COG3586	endonuclease activity
M2J83_RS03355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2J83_RS03365	COG0583	DNA-binding transcription factor activity
M2J83_RS03375	COG0464	growth
M2J83_RS03405	COG1535	isochorismatase
M2J83_RS03405	COG3433	isochorismatase activity
M2J83_RS03430	COG0583	DNA-binding transcription factor activity
M2J83_RS03435	COG0387	Pfam Sodium calcium exchanger
M2J83_RS03450	COG0477	Major facilitator Superfamily
M2J83_RS03455	COG0235	Class ii aldolase
M2J83_RS03470	COG3391	amine dehydrogenase activity
M2J83_RS03475	COG0590	tRNA wobble adenosine to inosine editing
M2J83_RS03480	COG3257	ureidoglycine aminohydrolase activity
M2J83_RS03485	COG0583	DNA-binding transcription factor activity
M2J83_RS03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2J83_RS03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_RS03495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_RS03505	COG0489	protein tyrosine kinase activity
M2J83_RS03530	COG2081	HI0933 family
M2J83_RS03535	COG0509	glycine decarboxylation via glycine cleavage system
M2J83_RS03545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2J83_RS03550	COG1765	OsmC-like protein
M2J83_RS03555	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_RS03580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M2J83_RS03585	COG0469	pyruvate kinase activity
M2J83_RS03590	COG3193	protein, possibly involved in utilization of glycolate and propanediol
M2J83_RS03600	COG2084	Dehydrogenase
M2J83_RS03605	COG3622	Belongs to the hyi family
M2J83_RS03610	COG3960	tartronate-semialdehyde synthase activity
M2J83_RS03615	COG0583	DNA-binding transcription factor activity
M2J83_RS03625	COG2233	PERMEase
M2J83_RS03630	COG1942	4-Oxalocrotonate Tautomerase
M2J83_RS03635	COG0235	Class ii aldolase
M2J83_RS03645	COG3648	Uricase
M2J83_RS03645	COG3195	allantoin biosynthetic process
M2J83_RS03655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2J83_RS03660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M2J83_RS03675	COG0438	transferase activity, transferring glycosyl groups
M2J83_RS03685	COG0438	transferase activity, transferring glycosyl groups
M2J83_RS03695	COG0277	FAD linked oxidase domain protein
M2J83_RS03705	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_RS03710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M2J83_RS03720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS03730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2J83_RS03740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M2J83_RS03755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2J83_RS03760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2J83_RS03765	COG0193	aminoacyl-tRNA hydrolase activity
M2J83_RS03775	COG0012	GTP binding
M2J83_RS03810	COG0488	(ABC) transporter
M2J83_RS03830	COG0288	reversible hydration of carbon dioxide
M2J83_RS03835	COG0583	DNA-binding transcription factor activity
M2J83_RS03865	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M2J83_RS03875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_RS03880	COG3088	subunit of a heme lyase
M2J83_RS03885	COG4235	cytochrome complex assembly
M2J83_RS03890	COG0785	Cytochrome C biogenesis protein
M2J83_RS03900	COG2169	Transcriptional regulator
M2J83_RS03900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_RS03920	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS03930	COG0411	ABC transporter
M2J83_RS03940	COG1858	cytochrome C peroxidase
M2J83_RS03945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M2J83_RS03950	COG1959	2 iron, 2 sulfur cluster binding
M2J83_RS03955	COG2346	COG2346, Truncated hemoglobins
M2J83_RS03960	COG0463	Glycosyl transferase, family 2
M2J83_RS04000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M2J83_RS04005	COG3383	formate dehydrogenase (NAD+) activity
M2J83_RS04020	COG1910	domain protein
M2J83_RS04025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M2J83_RS04035	COG0303	'Molybdopterin
M2J83_RS04040	COG0521	Mo-molybdopterin cofactor biosynthetic process
M2J83_RS04045	COG0314	molybdopterin synthase activity
M2J83_RS04055	COG0315	cyclic pyranopterin monophosphate synthase activity
M2J83_RS04085	COG0678	peroxiredoxin activity
M2J83_RS04100	COG0697	spore germination
M2J83_RS04105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M2J83_RS04140	COG2814	Major facilitator Superfamily
M2J83_RS04180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M2J83_RS04185	COG4535	Mg2 and Co2 transporter CorC
M2J83_RS04190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2J83_RS04195	COG1702	phosphate starvation-inducible protein PhoH
M2J83_RS04200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M2J83_RS04215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M2J83_RS04220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M2J83_RS04225	COG1862	Preprotein translocase
M2J83_RS04230	COG0343	queuine tRNA-ribosyltransferase activity
M2J83_RS04235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2J83_RS04240	COG2027	D-alanyl-D-alanine carboxypeptidase
M2J83_RS04245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2J83_RS04255	COG4575	ribosome binding
M2J83_RS04270	COG0583	DNA-binding transcription factor activity
M2J83_RS04285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_RS04300	COG0154	amidase activity
M2J83_RS04310	COG0477	Major facilitator Superfamily
M2J83_RS04325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M2J83_RS04335	COG0436	Aminotransferase
M2J83_RS04345	COG0281	malic enzyme
M2J83_RS04345	COG0280	phosphate acetyltransferase
M2J83_RS04355	COG2732	(Barnase) inhibitor
M2J83_RS04360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2J83_RS04365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M2J83_RS04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M2J83_RS04375	COG0126	phosphoglycerate kinase activity
M2J83_RS04395	COG0521	Mo-molybdopterin cofactor biosynthetic process
M2J83_RS04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M2J83_RS04410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M2J83_RS04415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2J83_RS04420	COG0009	L-threonylcarbamoyladenylate synthase
M2J83_RS04430	COG2030	dehydratase
M2J83_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS04435	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS04445	COG0405	Gamma-glutamyltransferase
M2J83_RS04455	COG0579	oxidoreductase
M2J83_RS04460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2J83_RS04465	COG0259	pyridoxamine-phosphate oxidase activity
M2J83_RS04475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M2J83_RS04490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2J83_RS04500	COG1215	transferase activity, transferring glycosyl groups
M2J83_RS04510	COG0488	(ABC) transporter
M2J83_RS04530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M2J83_RS04535	COG2894	cell division
M2J83_RS04545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2J83_RS04550	COG1271	oxidase subunit
M2J83_RS04555	COG1294	oxidase, subunit
M2J83_RS04560	COG0038	chloride channel
M2J83_RS04570	COG0514	ATP-dependent DNA helicase (RecQ)
M2J83_RS04575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2J83_RS04580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2J83_RS04585	COG0633	Ferredoxin
M2J83_RS04590	COG0488	(ABC) transporter
M2J83_RS04600	COG2001	Belongs to the MraZ family
M2J83_RS04605	COG0275	rRNA processing
M2J83_RS04610	COG3116	cell division
M2J83_RS04620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2J83_RS04625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2J83_RS04630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2J83_RS04640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2J83_RS04645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2J83_RS04650	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2J83_RS04655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M2J83_RS04670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M2J83_RS04680	COG1196	nuclear chromosome segregation
M2J83_RS04680	COG0741	lytic transglycosylase activity
M2J83_RS04680	COG0739	heme binding
M2J83_RS04685	COG0653	protein targeting
M2J83_RS04695	COG2239	Acts as a magnesium transporter
M2J83_RS04705	COG1473	amidohydrolase
M2J83_RS04710	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS04720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS04720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M2J83_RS04735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2J83_RS04740	COG2011	ABC-type metal ion transport system permease component
M2J83_RS04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS04755	COG0765	amino acid transport
M2J83_RS04760	COG1126	abc transporter atp-binding protein
M2J83_RS04785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_RS04790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_RS04795	COG0700	Nucleoside recognition
M2J83_RS04810	COG0204	Acyl-transferase
M2J83_RS04815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M2J83_RS04820	COG0751	glycine-tRNA ligase activity
M2J83_RS04825	COG0752	glycyl-tRNA synthetase alpha subunit
M2J83_RS04835	COG1024	Enoyl-CoA hydratase
M2J83_RS04845	COG1309	transcriptional regulator
M2J83_RS04855	COG2814	Major facilitator Superfamily
M2J83_RS04870	COG1573	uracil-dna glycosylase
M2J83_RS04875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M2J83_RS04880	COG0617	tRNA 3'-terminal CCA addition
M2J83_RS04890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2J83_RS04895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M2J83_RS04900	COG1953	Uracil, thiamine, allantoin
M2J83_RS04905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2J83_RS04910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M2J83_RS04915	COG0586	Pfam SNARE associated Golgi protein
M2J83_RS04920	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2J83_RS04925	COG0802	atpase or kinase
M2J83_RS04935	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS04970	COG0463	Glycosyl transferase, family 2
M2J83_RS04975	COG0281	malic enzyme
M2J83_RS04975	COG0280	phosphate acetyltransferase
M2J83_RS04980	COG0583	DNA-binding transcription factor activity
M2J83_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS04990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_RS05010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS05040	COG1733	regulation of RNA biosynthetic process
M2J83_RS05045	COG2910	NAD(P)H-binding
M2J83_RS05055	COG2223	nitrite transmembrane transporter activity
M2J83_RS05060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2J83_RS05065	COG4974	Belongs to the 'phage' integrase family
M2J83_RS05070	COG0725	ABC transporter, periplasmic molybdate-binding protein
M2J83_RS05075	COG4149	molybdate abc transporter
M2J83_RS05080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M2J83_RS05095	COG1074	ATP-dependent DNA helicase activity
M2J83_RS05130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS05150	COG3391	amine dehydrogenase activity
M2J83_RS05155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M2J83_RS05160	COG0505	Belongs to the CarA family
M2J83_RS05165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2J83_RS05185	COG2233	PERMEase
M2J83_RS05190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2J83_RS05195	COG1534	Rna-binding protein
M2J83_RS05200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M2J83_RS05205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2J83_RS05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2J83_RS05225	COG0248	Ppx GppA phosphatase
M2J83_RS05230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M2J83_RS05250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2J83_RS05255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M2J83_RS05305	COG1231	oxidoreductase activity
M2J83_RS05315	COG2323	membrane
M2J83_RS05325	COG1368	sulfuric ester hydrolase activity
M2J83_RS05355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_RS05360	COG3327	negative regulation of DNA-templated transcription, initiation
M2J83_RS05365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2J83_RS05380	COG0009	L-threonylcarbamoyladenylate synthase
M2J83_RS05385	COG1994	Peptidase M50
M2J83_RS05390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M2J83_RS05395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M2J83_RS05410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M2J83_RS05420	COG0156	8-amino-7-oxononanoate synthase activity
M2J83_RS05425	COG2124	cytochrome p450
M2J83_RS05435	COG3135	benzoate transporter
M2J83_RS05440	COG2850	peptidyl-arginine hydroxylation
M2J83_RS05450	COG3391	amine dehydrogenase activity
M2J83_RS05460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_RS05465	COG0577	efflux transmembrane transporter activity
M2J83_RS05465	COG1136	(ABC) transporter
M2J83_RS05470	COG1538	Outer membrane efflux protein
M2J83_RS05475	COG0363	glucosamine-6-phosphate deaminase activity
M2J83_RS05480	COG1132	(ABC) transporter
M2J83_RS05490	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS05500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_RS05510	COG0668	transmembrane transport
M2J83_RS05555	COG0154	amidase activity
M2J83_RS05570	COG0483	inositol monophosphate 1-phosphatase activity
M2J83_RS05575	COG1253	flavin adenine dinucleotide binding
M2J83_RS05580	COG1968	undecaprenyl-diphosphatase activity
M2J83_RS05605	COG0215	cysteine-tRNA ligase activity
M2J83_RS05615	COG0825	malonyl-CoA metabolic process
M2J83_RS05620	COG0037	tRNA processing
M2J83_RS05645	COG0330	HflC and HflK could
M2J83_RS05660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_RS05680	COG4208	sulfate ABC transporter
M2J83_RS05685	COG3842	ATPase activity
M2J83_RS05695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M2J83_RS05725	COG1304	FMN binding
M2J83_RS05730	COG0435	Glutathione S-transferase
M2J83_RS05735	COG0655	NAD(P)H dehydrogenase (quinone) activity
M2J83_RS05755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2J83_RS05760	COG2363	Small membrane protein
M2J83_RS05765	COG0598	Magnesium transport protein CorA
M2J83_RS05770	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS05780	COG0747	negative chemotaxis
M2J83_RS05790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_RS05795	COG4172	Belongs to the ABC transporter superfamily
M2J83_RS05805	COG3284	Transcriptional regulator
M2J83_RS05810	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS05815	COG1454	alcohol dehydrogenase
M2J83_RS05820	COG1715	Restriction endonuclease
M2J83_RS05835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS05845	COG0183	Belongs to the thiolase family
M2J83_RS05850	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS05865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2J83_RS05890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS05920	COG3829	transcription factor binding
M2J83_RS05925	COG0477	Major facilitator Superfamily
M2J83_RS05935	COG0039	L-malate dehydrogenase activity
M2J83_RS05940	COG2188	Transcriptional regulator
M2J83_RS05945	COG2009	succinate dehydrogenase
M2J83_RS05955	COG1053	succinate dehydrogenase
M2J83_RS05960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M2J83_RS05965	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M2J83_RS05970	COG0372	Belongs to the citrate synthase family
M2J83_RS05975	COG2186	Transcriptional regulator
M2J83_RS05980	COG1620	l-lactate permease
M2J83_RS05985	COG0280	phosphate acetyltransferase
M2J83_RS05985	COG0281	malic enzyme
M2J83_RS05990	COG0567	Dehydrogenase, E1 component
M2J83_RS05995	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_RS06000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_RS06005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M2J83_RS06030	COG2183	response to ionizing radiation
M2J83_RS06035	COG1199	ATP-dependent helicase activity
M2J83_RS06045	COG1733	regulation of RNA biosynthetic process
M2J83_RS06070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS06080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_RS06080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS06095	COG0564	pseudouridine synthase activity
M2J83_RS06105	COG3243	poly(R)-hydroxyalkanoic acid synthase
M2J83_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS06115	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
M2J83_RS06140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2J83_RS06145	COG1187	pseudouridine synthase activity
M2J83_RS06150	COG0779	Required for maturation of 30S ribosomal subunits
M2J83_RS06155	COG2251	uridine kinase activity
M2J83_RS06155	COG0195	Participates in both transcription termination and antitermination
M2J83_RS06160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M2J83_RS06165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2J83_RS06170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2J83_RS06175	COG1217	gtp-binding protein TYPA
M2J83_RS06180	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_RS06190	COG4160	amino acid transport
M2J83_RS06195	COG4215	(ABC) transporter
M2J83_RS06215	COG1283	sodium-dependent phosphate transmembrane transporter activity
M2J83_RS06225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M2J83_RS06235	COG0456	acetyltransferase
M2J83_RS06240	COG0501	Belongs to the peptidase M48B family
M2J83_RS06260	COG1722	exodeoxyribonuclease VII activity
M2J83_RS06265	COG0142	geranyltranstransferase activity
M2J83_RS06275	COG1469	GTP cyclohydrolase I activity
M2J83_RS06280	COG0360	Binds together with S18 to 16S ribosomal RNA
M2J83_RS06285	COG2965	DNA replication, synthesis of RNA primer
M2J83_RS06290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2J83_RS06300	COG0305	Participates in initiation and elongation during chromosome replication
M2J83_RS06310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M2J83_RS06315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M2J83_RS06320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M2J83_RS06330	COG0436	Aminotransferase
M2J83_RS06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2J83_RS06350	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M2J83_RS06355	COG1562	ergosterol biosynthetic process
M2J83_RS06360	COG1562	ergosterol biosynthetic process
M2J83_RS06365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M2J83_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS06395	COG3842	ATPase activity
M2J83_RS06400	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2J83_RS06405	COG1177	transmembrane transport
M2J83_RS06410	COG1393	Belongs to the ArsC family
M2J83_RS06415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2J83_RS06420	COG0704	Plays a role in the regulation of phosphate uptake
M2J83_RS06425	COG2203	Gaf domain
M2J83_RS06425	COG3706	GGDEF domain
M2J83_RS06425	COG5001	Diguanylate cyclase
M2J83_RS06425	COG4251	negative regulation of phosphorylation
M2J83_RS06430	COG0659	secondary active sulfate transmembrane transporter activity
M2J83_RS06435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M2J83_RS06440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M2J83_RS06440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M2J83_RS06445	COG1643	Atp-dependent helicase
M2J83_RS06455	COG0438	transferase activity, transferring glycosyl groups
M2J83_RS06460	COG0726	polysaccharide deacetylase
M2J83_RS06475	COG0438	transferase activity, transferring glycosyl groups
M2J83_RS06500	COG1132	(ABC) transporter
M2J83_RS06520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M2J83_RS06525	COG1228	amidohydrolase
M2J83_RS06565	COG2186	Transcriptional regulator
M2J83_RS06570	COG0277	FAD linked oxidase domain protein
M2J83_RS06575	COG0277	FAD linked oxidase domain protein
M2J83_RS06580	COG0247	lactate metabolic process
M2J83_RS06605	COG0628	permease
M2J83_RS06610	COG1283	sodium-dependent phosphate transmembrane transporter activity
M2J83_RS06625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS06635	COG0697	spore germination
M2J83_RS06655	COG3094	Invasion gene expression up-regulator, SirB
M2J83_RS06665	COG0640	Transcriptional regulator
M2J83_RS06690	COG0659	secondary active sulfate transmembrane transporter activity
M2J83_RS06695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_RS06705	COG2314	TM2 domain
M2J83_RS06710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M2J83_RS06715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2J83_RS06720	COG0791	NLP P60 protein
M2J83_RS06740	COG1360	Flagellar Motor Protein
M2J83_RS06750	COG0835	chemotaxis
M2J83_RS06755	COG0840	transmembrane signaling receptor activity
M2J83_RS06760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M2J83_RS06770	COG0745	RESPONSE REGULATOR receiver
M2J83_RS06775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M2J83_RS06785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M2J83_RS06795	COG3550	peptidyl-serine autophosphorylation
M2J83_RS06820	COG1815	bacterial-type flagellum-dependent cell motility
M2J83_RS06825	COG1558	bacterial-type flagellum-dependent cell motility
M2J83_RS06830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M2J83_RS06870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M2J83_RS06895	COG2176	DNA-directed DNA polymerase activity
M2J83_RS06905	COG1987	bacterial-type flagellum assembly
M2J83_RS06920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M2J83_RS06945	COG1157	protein secretion by the type III secretion system
M2J83_RS06960	COG1766	The M ring may be actively involved in energy transduction
M2J83_RS06965	COG1677	Flagellar hook-basal body complex protein FliE
M2J83_RS06970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M2J83_RS06995	COG1334	flagellar protein FlaG
M2J83_RS07000	COG1191	sigma factor activity
M2J83_RS07055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_RS07075	COG2733	membrane
M2J83_RS07080	COG0840	transmembrane signaling receptor activity
M2J83_RS07085	COG0840	transmembrane signaling receptor activity
M2J83_RS07110	COG2610	gluconate transmembrane transporter activity
M2J83_RS07120	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2J83_RS07130	COG4521	taurine ABC transporter
M2J83_RS07135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_RS07140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS07150	COG0583	DNA-binding transcription factor activity
M2J83_RS07180	COG2824	Alkylphosphonate utilization operon protein PhnA
M2J83_RS07195	COG4771	TonB-dependent receptor
M2J83_RS07200	COG1858	cytochrome C peroxidase
M2J83_RS07220	COG1113	amino acid transport
M2J83_RS07240	COG0583	DNA-binding transcription factor activity
M2J83_RS07245	COG3755	Protein conserved in bacteria
M2J83_RS07250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2J83_RS07285	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_RS07310	COG1278	Cold shock
M2J83_RS07315	COG0642	Histidine kinase
M2J83_RS07325	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_RS07335	COG2863	cytochrome
M2J83_RS07340	COG3258	Cytochrome c
M2J83_RS07370	COG0025	NhaP-type Na H and K H
M2J83_RS07385	COG1289	transmembrane transporter activity
M2J83_RS07390	COG2252	PERMEase
M2J83_RS07410	COG1999	signal sequence binding
M2J83_RS07425	COG0069	glutamate synthase activity
M2J83_RS07435	COG1846	Transcriptional regulator
M2J83_RS07445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M2J83_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS07495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M2J83_RS07495	COG3264	Mechanosensitive ion channel
M2J83_RS07500	COG1511	domain protein
M2J83_RS07500	COG3264	Mechanosensitive ion channel
M2J83_RS07505	COG0477	Major facilitator Superfamily
M2J83_RS07520	COG1396	sequence-specific DNA binding
M2J83_RS07525	COG3437	response regulator, receiver
M2J83_RS07530	COG2198	Histidine kinase
M2J83_RS07530	COG0784	Response regulator, receiver
M2J83_RS07530	COG2205	protein histidine kinase activity
M2J83_RS07535	COG2239	Acts as a magnesium transporter
M2J83_RS07545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M2J83_RS07550	COG1490	D-aminoacyl-tRNA deacylase activity
M2J83_RS07565	COG0456	acetyltransferase
M2J83_RS07575	COG0501	Belongs to the peptidase M48B family
M2J83_RS07580	COG2814	Major facilitator Superfamily
M2J83_RS07585	COG0582	viral genome integration into host DNA
M2J83_RS07745	COG0740	serine-type endopeptidase activity
M2J83_RS07850	COG4115	mRNA cleavage
M2J83_RS07855	COG2161	toxin-antitoxin pair type II binding
M2J83_RS07985	COG3772	lysozyme
M2J83_RS08035	COG2199	diguanylate cyclase activity
M2J83_RS08050	COG1522	sequence-specific DNA binding
M2J83_RS08055	COG0626	cystathionine gamma-synthase activity
M2J83_RS08065	COG0494	nUDIX hydrolase
M2J83_RS08070	COG2832	Protein of unknown function (DUF454)
M2J83_RS08080	COG0137	argininosuccinate synthase activity
M2J83_RS08095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M2J83_RS08105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M2J83_RS08110	COG2205	protein histidine kinase activity
M2J83_RS08115	COG0745	RESPONSE REGULATOR receiver
M2J83_RS08120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M2J83_RS08130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_RS08135	COG0268	Binds directly to 16S ribosomal RNA
M2J83_RS08140	COG0728	peptidoglycan biosynthetic process
M2J83_RS08150	COG0563	adenylate kinase activity
M2J83_RS08155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M2J83_RS08160	COG2835	tetraacyldisaccharide 4'-kinase activity
M2J83_RS08170	COG0848	biopolymer transport protein
M2J83_RS08175	COG0811	peptide transport
M2J83_RS08180	COG1570	exodeoxyribonuclease VII activity
M2J83_RS08185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2J83_RS08195	COG0183	Belongs to the thiolase family
M2J83_RS08205	COG1278	Cold shock
M2J83_RS08210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M2J83_RS08215	COG0542	response to heat
M2J83_RS08220	COG2995	paraquat-inducible protein a
M2J83_RS08225	COG3008	intermembrane lipid transfer
M2J83_RS08225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_RS08280	COG0300	oxidoreductase activity
M2J83_RS08290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M2J83_RS08295	COG0756	dUTP diphosphatase activity
M2J83_RS08305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2J83_RS08310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2J83_RS08315	COG0196	riboflavin kinase activity
M2J83_RS08320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M2J83_RS08325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2J83_RS08325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2J83_RS08335	COG0210	DNA helicase
M2J83_RS08390	COG0488	(ABC) transporter
M2J83_RS08395	COG2890	protein-(glutamine-N5) methyltransferase activity
M2J83_RS08400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2J83_RS08405	COG2171	N-acyltransferase activity
M2J83_RS08415	COG2207	Transcriptional regulator
M2J83_RS08425	COG0471	metal ion transport
M2J83_RS08425	COG3273	potassium ion transport
M2J83_RS08470	COG0789	Transcriptional regulator
M2J83_RS08485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS08490	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2J83_RS08495	COG0740	serine-type endopeptidase activity
M2J83_RS08505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M2J83_RS08515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2J83_RS08525	COG0556	nucleotide-excision repair
M2J83_RS08530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2J83_RS08540	COG1104	cysteine desulfurase activity
M2J83_RS08550	COG0316	Belongs to the HesB IscA family
M2J83_RS08560	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS08565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2J83_RS08570	COG4221	oxidoreductase activity
M2J83_RS08580	COG0840	transmembrane signaling receptor activity
M2J83_RS08585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M2J83_RS08590	COG0697	spore germination
M2J83_RS08595	COG0385	Bile acid
M2J83_RS08605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2J83_RS08620	COG1136	(ABC) transporter
M2J83_RS08625	COG0084	hydrolase, TatD family'
M2J83_RS08640	COG0613	PHP domain protein
M2J83_RS08650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M2J83_RS08650	COG0047	phosphoribosylformylglycinamidine synthase activity
M2J83_RS08675	COG0519	Catalyzes the synthesis of GMP from XMP
M2J83_RS08675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2J83_RS08700	COG4691	Plasmid stability protein
M2J83_RS08730	COG0798	PFAM Bile acid sodium symporter
M2J83_RS08770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_RS08820	COG2076	Multidrug Resistance protein
M2J83_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS08830	COG0583	DNA-binding transcription factor activity
M2J83_RS08845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M2J83_RS08855	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS08865	COG2378	regulation of single-species biofilm formation
M2J83_RS08870	COG0523	cobalamin synthesis protein
M2J83_RS08875	COG1469	GTP cyclohydrolase I activity
M2J83_RS08880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2J83_RS08890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2J83_RS08895	COG0735	belongs to the Fur family
M2J83_RS08900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M2J83_RS08920	COG0745	RESPONSE REGULATOR receiver
M2J83_RS08925	COG2207	Transcriptional regulator
M2J83_RS08945	COG1942	4-Oxalocrotonate Tautomerase
M2J83_RS08960	COG2070	2-Nitropropane dioxygenase
M2J83_RS08985	COG1309	transcriptional regulator
M2J83_RS09010	COG0625	glutathione transferase activity
M2J83_RS09015	COG0740	serine-type endopeptidase activity
M2J83_RS09065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M2J83_RS09075	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS09100	COG0640	Transcriptional regulator
M2J83_RS09125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_RS09155	COG3485	protocatechuate 3,4-dioxygenase
M2J83_RS09165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M2J83_RS09170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M2J83_RS09180	COG3135	benzoate transporter
M2J83_RS09185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2J83_RS09190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M2J83_RS09205	COG4555	ABC transporter
M2J83_RS09215	COG2197	response regulator
M2J83_RS09220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2J83_RS09245	COG1846	Transcriptional regulator
M2J83_RS09250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS09255	COG2271	Major facilitator Superfamily
M2J83_RS09265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2J83_RS09275	COG0697	spore germination
M2J83_RS09300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M2J83_RS09305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M2J83_RS09310	COG0667	Aldo Keto reductase
M2J83_RS09330	COG0582	viral genome integration into host DNA
M2J83_RS09370	COG0582	viral genome integration into host DNA
M2J83_RS09540	COG5484	DNA packaging
M2J83_RS09540	COG3728	DNA packaging
M2J83_RS09545	COG5410	chromosome segregation
M2J83_RS09650	COG3772	lysozyme
M2J83_RS09690	COG1272	protein, Hemolysin III
M2J83_RS09695	COG3422	double-strand break repair
M2J83_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS09720	COG0765	amino acid transport
M2J83_RS09725	COG0765	amino acid transport
M2J83_RS09730	COG1126	abc transporter atp-binding protein
M2J83_RS09780	COG2871	sodium ion transport
M2J83_RS09810	COG2814	Major facilitator Superfamily
M2J83_RS09820	COG1280	lysine exporter protein (LysE YggA)
M2J83_RS09840	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_RS09865	COG0330	HflC and HflK could
M2J83_RS09870	COG1585	Membrane protein implicated in regulation of membrane protease activity
M2J83_RS09875	COG2226	methyltransferase
M2J83_RS09885	COG3042	response to heat
M2J83_RS09895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2J83_RS09915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2J83_RS09920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2J83_RS09935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2J83_RS09940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2J83_RS09970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2J83_RS09975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2J83_RS09980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2J83_RS09985	COG0072	phenylalanine-tRNA ligase activity
M2J83_RS09985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2J83_RS10000	COG2833	Protein of unknown function (DUF455)
M2J83_RS10010	COG5265	(ABC) transporter
M2J83_RS10015	COG1959	2 iron, 2 sulfur cluster binding
M2J83_RS10020	COG0719	Fe-S assembly protein
M2J83_RS10025	COG0396	ATPase activity
M2J83_RS10030	COG0719	Fe-S assembly protein
M2J83_RS10040	COG0822	iron-sulfur transferase activity
M2J83_RS10045	COG2151	metal-sulfur cluster biosynthetic enzyme
M2J83_RS10065	COG1538	Outer membrane efflux protein
M2J83_RS10100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2J83_RS10105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2J83_RS10110	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2J83_RS10130	COG0747	negative chemotaxis
M2J83_RS10135	COG0601	transmembrane transport
M2J83_RS10140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_RS10145	COG4172	Belongs to the ABC transporter superfamily
M2J83_RS10155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2J83_RS10200	COG3048	D-serine ammonia-lyase activity
M2J83_RS10205	COG3258	Cytochrome c
M2J83_RS10220	COG3949	Membrane
M2J83_RS10230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M2J83_RS10245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2J83_RS10250	COG0569	domain protein
M2J83_RS10255	COG1902	pentaerythritol trinitrate reductase activity
M2J83_RS10265	COG1610	YqeY-like protein
M2J83_RS10270	COG0587	DNA-directed DNA polymerase activity
M2J83_RS10305	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS10310	COG0583	DNA-binding transcription factor activity
M2J83_RS10315	COG1686	Belongs to the peptidase S11 family
M2J83_RS10330	COG1360	Flagellar Motor Protein
M2J83_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS10345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_RS10350	COG4221	oxidoreductase activity
M2J83_RS10360	COG0307	riboflavin synthase, alpha
M2J83_RS10405	COG3846	protein secretion by the type IV secretion system
M2J83_RS10420	COG3451	type IV secretory pathway VirB4
M2J83_RS10430	COG3838	Conjugal transfer protein Trbc
M2J83_RS10435	COG4962	Type ii secretion system protein e
M2J83_RS10455	COG0583	DNA-binding transcription factor activity
M2J83_RS10510	COG4959	Type IV secretory pathway protease TraF
M2J83_RS10525	COG1192	Involved in chromosome partitioning
M2J83_RS10565	COG5489	Protein of unknown function (DUF736)
M2J83_RS10600	COG2003	Belongs to the UPF0758 family
M2J83_RS10675	COG2233	PERMEase
M2J83_RS10680	COG0071	Belongs to the small heat shock protein (HSP20) family
M2J83_RS10685	COG1473	amidohydrolase
M2J83_RS10725	COG2816	NAD+ diphosphatase activity
M2J83_RS10730	COG1561	YicC-like family, N-terminal region
M2J83_RS10745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2J83_RS10750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M2J83_RS10755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2J83_RS10760	COG0174	glutamine synthetase
M2J83_RS10765	COG2153	protein acetylation
M2J83_RS10785	COG3842	ATPase activity
M2J83_RS10790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_RS10795	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_RS10810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2J83_RS10820	COG0783	Belongs to the Dps family
M2J83_RS10830	COG3842	ATPase activity
M2J83_RS10835	COG0395	ABC-type sugar transport system, permease component
M2J83_RS10840	COG1175	transmembrane transport
M2J83_RS10845	COG1653	transport
M2J83_RS10860	COG0559	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS10880	COG0625	glutathione transferase activity
M2J83_RS10890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS10905	COG0114	fumarate hydratase activity
M2J83_RS10910	COG2133	pyrroloquinoline quinone binding
M2J83_RS10915	COG2226	methyltransferase
M2J83_RS10920	COG0589	response to stress
M2J83_RS10930	COG2207	Transcriptional regulator
M2J83_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS10950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS10955	COG2807	transmembrane transport
M2J83_RS10965	COG0583	DNA-binding transcription factor activity
M2J83_RS10995	COG0583	DNA-binding transcription factor activity
M2J83_RS11000	COG4974	Belongs to the 'phage' integrase family
M2J83_RS11015	COG2132	Multicopper oxidase
M2J83_RS11020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M2J83_RS11190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M2J83_RS11220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2J83_RS11225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2J83_RS11230	COG0697	spore germination
M2J83_RS11310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2J83_RS11315	COG0210	DNA helicase
M2J83_RS11340	COG2003	Belongs to the UPF0758 family
M2J83_RS11430	COG2894	cell division
M2J83_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS11460	COG3038	cytochrome b561
M2J83_RS11470	COG2353	YceI-like domain
M2J83_RS11475	COG1393	Belongs to the ArsC family
M2J83_RS11480	COG0625	glutathione transferase activity
M2J83_RS11505	COG0084	hydrolase, TatD family'
M2J83_RS11510	COG0470	DNA polymerase III
M2J83_RS11520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2J83_RS11540	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS11545	COG2914	Belongs to the UPF0125 (RnfH) family
M2J83_RS11550	COG2867	negative regulation of translational initiation
M2J83_RS11555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2J83_RS11560	COG1252	NADH dehydrogenase
M2J83_RS11585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2J83_RS11590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2J83_RS11595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M2J83_RS11605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2J83_RS11610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M2J83_RS11620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_RS11630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M2J83_RS11635	COG0575	Belongs to the CDS family
M2J83_RS11640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2J83_RS11645	COG0233	cytoplasmic translational termination
M2J83_RS11650	COG0528	UMP kinase activity
M2J83_RS11655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2J83_RS11660	COG0052	Belongs to the universal ribosomal protein uS2 family
M2J83_RS11665	COG0024	Methionine aminopeptidase
M2J83_RS11670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M2J83_RS11695	COG1286	toxin biosynthetic process
M2J83_RS11705	COG0285	dihydrofolate synthase activity
M2J83_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_RS11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2J83_RS11720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M2J83_RS11735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2J83_RS11745	COG1999	signal sequence binding
M2J83_RS11750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2J83_RS11755	COG0640	Transcriptional regulator
M2J83_RS11770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS11775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_RS11780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS11785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M2J83_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS11815	COG0183	Belongs to the thiolase family
M2J83_RS11835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M2J83_RS11845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_RS11850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_RS11855	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M2J83_RS11875	COG0183	Belongs to the thiolase family
M2J83_RS11880	COG0183	Belongs to the thiolase family
M2J83_RS11890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M2J83_RS11925	COG0194	GDP metabolic process
M2J83_RS11930	COG1758	RNA polymerase activity
M2J83_RS11935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2J83_RS11945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2J83_RS11950	COG0739	heme binding
M2J83_RS11955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_RS11960	COG0584	glycerophosphoryl diester phosphodiesterase
M2J83_RS11965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M2J83_RS11970	COG1187	pseudouridine synthase activity
M2J83_RS11975	COG3161	chorismate lyase activity
M2J83_RS11980	COG2814	Major facilitator Superfamily
M2J83_RS11985	COG0656	L-ascorbic acid biosynthetic process
M2J83_RS11995	COG0668	transmembrane transport
M2J83_RS12000	COG0165	Argininosuccinate lyase
M2J83_RS12005	COG1940	carbohydrate kinase activity
M2J83_RS12005	COG1846	Transcriptional regulator
M2J83_RS12015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS12025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2J83_RS12035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M2J83_RS12040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M2J83_RS12045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2J83_RS12050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2J83_RS12055	COG2252	PERMEase
M2J83_RS12060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_RS12080	COG0488	(ABC) transporter
M2J83_RS12085	COG1619	proteins homologs of microcin C7 resistance protein MccF
M2J83_RS12090	COG0590	tRNA wobble adenosine to inosine editing
M2J83_RS12095	COG1131	(ABC) transporter
M2J83_RS12100	COG0842	Transport permease protein
M2J83_RS12110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_RS12110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS12115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M2J83_RS12120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M2J83_RS12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS12135	COG2022	thiamine diphosphate biosynthetic process
M2J83_RS12155	COG1414	Transcriptional regulator
M2J83_RS12165	COG0730	response to heat
M2J83_RS12175	COG1666	GTP binding
M2J83_RS12180	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS12185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M2J83_RS12190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2J83_RS12190	COG0519	Catalyzes the synthesis of GMP from XMP
M2J83_RS12195	COG2207	Transcriptional regulator
M2J83_RS12205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_RS12210	COG0135	phosphoribosylanthranilate isomerase activity
M2J83_RS12215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS12225	COG0101	tRNA pseudouridine synthase activity
M2J83_RS12235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M2J83_RS12260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M2J83_RS12270	COG4566	intracellular signal transduction
M2J83_RS12285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2J83_RS12290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M2J83_RS12300	COG1295	ribonuclease BN
M2J83_RS12310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2J83_RS12345	COG4964	Belongs to the GSP D family
M2J83_RS12385	COG1595	DNA-templated transcription, initiation
M2J83_RS12405	COG2959	enzyme of heme biosynthesis
M2J83_RS12415	COG0181	hydroxymethylbilane synthase activity
M2J83_RS12425	COG0861	Integral membrane protein TerC family
M2J83_RS12435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M2J83_RS12440	COG0045	succinate-CoA ligase (ADP-forming) activity
M2J83_RS12455	COG0583	DNA-binding transcription factor activity
M2J83_RS12460	COG2137	regulation of response to DNA damage stimulus
M2J83_RS12465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2J83_RS12480	COG0477	Major facilitator Superfamily
M2J83_RS12495	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS12500	COG1024	Enoyl-CoA hydratase
M2J83_RS12505	COG3162	membrane
M2J83_RS12520	COG0540	Belongs to the ATCase OTCase family
M2J83_RS12535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2J83_RS12550	COG2070	2-Nitropropane dioxygenase
M2J83_RS12560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M2J83_RS12560	COG2111	Na H antiporter
M2J83_RS12565	COG1006	Multisubunit Na H antiporter MnhC subunit
M2J83_RS12570	COG0651	ATP synthesis coupled electron transport
M2J83_RS12580	COG2212	antiporter activity
M2J83_RS12595	COG3158	transport of potassium into the cell
M2J83_RS12600	COG0642	Histidine kinase
M2J83_RS12625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M2J83_RS12630	COG4208	sulfate ABC transporter
M2J83_RS12635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_RS12640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M2J83_RS12660	COG1278	Cold shock
M2J83_RS12675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_RS12675	COG1648	precorrin-2 dehydrogenase activity
M2J83_RS12705	COG0535	radical SAM domain protein
M2J83_RS12710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_RS12710	COG1648	precorrin-2 dehydrogenase activity
M2J83_RS12720	COG2010	Cytochrome c
M2J83_RS12725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS12730	COG0626	cystathionine gamma-synthase activity
M2J83_RS12735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2J83_RS12740	COG0557	exoribonuclease II activity
M2J83_RS12760	COG0765	amino acid transport
M2J83_RS12765	COG0765	amino acid transport
M2J83_RS12770	COG1126	abc transporter atp-binding protein
M2J83_RS12785	COG1850	ribulose-bisphosphate carboxylase activity
M2J83_RS12805	COG2375	cellular response to nickel ion
M2J83_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS12835	COG0583	DNA-binding transcription factor activity
M2J83_RS12840	COG3842	ATPase activity
M2J83_RS12845	COG1175	transmembrane transport
M2J83_RS12850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2J83_RS12855	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_RS12875	COG0412	Dienelactone hydrolase
M2J83_RS12880	COG3530	Putative quorum-sensing-regulated virulence factor
M2J83_RS12885	COG0625	glutathione transferase activity
M2J83_RS12890	COG1741	Belongs to the pirin family
M2J83_RS12900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_RS12905	COG2814	Major facilitator Superfamily
M2J83_RS12910	COG2807	transmembrane transport
M2J83_RS12915	COG2207	Transcriptional regulator
M2J83_RS12920	COG3135	benzoate transporter
M2J83_RS12945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_RS12955	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_RS12965	COG0745	RESPONSE REGULATOR receiver
M2J83_RS12970	COG2205	protein histidine kinase activity
M2J83_RS12985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M2J83_RS12990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M2J83_RS12995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M2J83_RS13005	COG0330	HflC and HflK could
M2J83_RS13010	COG0330	HflC and HflK could
M2J83_RS13015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2J83_RS13020	COG1923	regulation of RNA biosynthetic process
M2J83_RS13030	COG1160	GTP binding
M2J83_RS13035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_RS13040	COG2976	Protein conserved in bacteria
M2J83_RS13060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2J83_RS13065	COG0105	UTP biosynthetic process
M2J83_RS13075	COG0336	Belongs to the RNA methyltransferase TrmD family
M2J83_RS13085	COG0228	four-way junction DNA binding
M2J83_RS13090	COG0425	Belongs to the sulfur carrier protein TusA family
M2J83_RS13095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2J83_RS13110	COG2351	hydroxyisourate hydrolase activity
M2J83_RS13145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS13170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2J83_RS13175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2J83_RS13200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2J83_RS13205	COG0601	transmembrane transport
M2J83_RS13235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M2J83_RS13240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2J83_RS13245	COG0542	response to heat
M2J83_RS13250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2J83_RS13265	COG0348	domain, Protein
M2J83_RS13285	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_RS13295	COG2217	Heavy metal translocating P-type atpase
M2J83_RS13300	COG2224	Isocitrate lyase
M2J83_RS13305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M2J83_RS13305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M2J83_RS13325	COG1472	Belongs to the glycosyl hydrolase 3 family
M2J83_RS13330	COG0736	holo-[acyl-carrier-protein] synthase activity
M2J83_RS13340	COG2050	protein possibly involved in aromatic compounds catabolism
M2J83_RS13345	COG1024	Enoyl-CoA hydratase
M2J83_RS13350	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS13355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M2J83_RS13360	COG2151	metal-sulfur cluster biosynthetic enzyme
M2J83_RS13365	COG3396	Phenylacetate-CoA oxygenase
M2J83_RS13370	COG3460	Phenylacetate-CoA oxygenase
M2J83_RS13375	COG3396	Phenylacetate-CoA oxygenase
M2J83_RS13380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M2J83_RS13385	COG0501	Belongs to the peptidase M48B family
M2J83_RS13390	COG1162	GTPase activity
M2J83_RS13400	COG0335	large ribosomal subunit rRNA binding
M2J83_RS13420	COG0450	alkyl hydroperoxide reductase
M2J83_RS13425	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS13440	COG0123	including yeast histone deacetylase and acetoin utilization protein
M2J83_RS13445	COG2951	lytic endotransglycosylase activity
M2J83_RS13455	COG1596	polysaccharide export
M2J83_RS13455	COG1555	photosystem II stabilization
M2J83_RS13460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_RS13465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M2J83_RS13470	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M2J83_RS13490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2J83_RS13495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M2J83_RS13500	COG0287	Prephenate dehydrogenase
M2J83_RS13510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M2J83_RS13525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M2J83_RS13545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M2J83_RS13555	COG4771	TonB-dependent receptor
M2J83_RS13570	COG0753	catalase activity
M2J83_RS13580	COG4335	DNA alkylation repair
M2J83_RS13590	COG0436	Aminotransferase
M2J83_RS13600	COG0251	oxidation-reduction process
M2J83_RS13605	COG1309	transcriptional regulator
M2J83_RS13615	COG0488	(ABC) transporter
M2J83_RS13670	COG0625	glutathione transferase activity
M2J83_RS13680	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M2J83_RS13685	COG1280	lysine exporter protein (LysE YggA)
M2J83_RS13705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_RS13715	COG5002	protein histidine kinase activity
M2J83_RS13720	COG2046	Belongs to the sulfate adenylyltransferase family
M2J83_RS13725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M2J83_RS13740	COG0840	transmembrane signaling receptor activity
M2J83_RS13745	COG2119	membrane
M2J83_RS13760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2J83_RS13765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M2J83_RS13780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M2J83_RS13785	COG2321	neutral zinc metallopeptidase
M2J83_RS13805	COG2175	clavaminate synthase activity
M2J83_RS13810	COG1846	Transcriptional regulator
M2J83_RS13815	COG0347	Belongs to the P(II) protein family
M2J83_RS13820	COG0004	ammonium transporteR
M2J83_RS13825	COG3909	cytochrome
M2J83_RS13835	COG0625	glutathione transferase activity
M2J83_RS13845	COG0657	acetylesterase activity
M2J83_RS13860	COG0730	response to heat
M2J83_RS13865	COG0482	sulfurtransferase activity
M2J83_RS13870	COG0277	FAD linked oxidase domain protein
M2J83_RS13875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M2J83_RS13880	COG2879	small protein
M2J83_RS13885	COG1966	Carbon starvation protein
M2J83_RS13890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS13895	COG0765	amino acid transport
M2J83_RS13900	COG0765	amino acid transport
M2J83_RS13905	COG1126	abc transporter atp-binding protein
M2J83_RS13910	COG0028	Belongs to the TPP enzyme family
M2J83_RS13915	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS13920	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
M2J83_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS13940	COG1116	anion transmembrane transporter activity
M2J83_RS13955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS13960	COG1414	Transcriptional regulator
M2J83_RS13970	COG5285	phytanoyl-CoA dioxygenase
M2J83_RS13975	COG0662	Cupin 2, conserved barrel domain protein
M2J83_RS13985	COG0456	acetyltransferase
M2J83_RS13990	COG1846	Transcriptional regulator
M2J83_RS14000	COG0312	modulator of DNA gyrase
M2J83_RS14015	COG0308	aminopeptidase N
M2J83_RS14020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M2J83_RS14035	COG0473	3-isopropylmalate dehydrogenase activity
M2J83_RS14045	COG0433	COG0433 Predicted ATPase
M2J83_RS14050	COG0217	transcriptional regulatory protein
M2J83_RS14055	COG0151	Belongs to the GarS family
M2J83_RS14065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2J83_RS14070	COG0799	negative regulation of ribosome biogenesis
M2J83_RS14075	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M2J83_RS14080	COG0424	maF-like protein
M2J83_RS14100	COG0023	Translation Initiation Factor
M2J83_RS14110	COG2084	Dehydrogenase
M2J83_RS14115	COG0625	glutathione transferase activity
M2J83_RS14120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M2J83_RS14125	COG1047	Peptidyl-prolyl cis-trans
M2J83_RS14130	COG2003	Belongs to the UPF0758 family
M2J83_RS14135	COG1737	Transcriptional regulator
M2J83_RS14140	COG0477	Major facilitator Superfamily
M2J83_RS14150	COG2271	Major facilitator Superfamily
M2J83_RS14165	COG0534	Mate efflux family protein
M2J83_RS14170	COG4175	Glycine betaine
M2J83_RS14175	COG4176	ABC-type proline glycine betaine transport system permease component
M2J83_RS14185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M2J83_RS14190	COG2814	Major facilitator Superfamily
M2J83_RS14195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2J83_RS14200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2J83_RS14205	COG0495	leucyl-tRNA aminoacylation
M2J83_RS14215	COG1466	dna polymerase III delta subunit
M2J83_RS14220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M2J83_RS14225	COG1981	membrane
M2J83_RS14240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2J83_RS14250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M2J83_RS14255	COG0148	phosphopyruvate hydratase activity
M2J83_RS14265	COG2814	Major facilitator Superfamily
M2J83_RS14280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M2J83_RS14290	COG0504	CTP synthase activity
M2J83_RS14325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M2J83_RS14335	COG0791	NLP P60 protein
M2J83_RS14345	COG0583	DNA-binding transcription factor activity
M2J83_RS14355	COG0583	DNA-binding transcription factor activity
M2J83_RS14365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M2J83_RS14380	COG1045	serine acetyltransferase
M2J83_RS14395	COG1381	Involved in DNA repair and RecF pathway recombination
M2J83_RS14400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2J83_RS14405	COG0571	ribonuclease III activity
M2J83_RS14420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2J83_RS14440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2J83_RS14445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2J83_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS14455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2J83_RS14460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2J83_RS14470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2J83_RS14475	COG1399	metal-binding, possibly nucleic acid-binding protein
M2J83_RS14480	COG0424	maF-like protein
M2J83_RS14490	COG3023	N-Acetylmuramoyl-L-alanine amidase
M2J83_RS14495	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M2J83_RS14500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M2J83_RS14505	COG0546	phosphoglycolate phosphatase activity
M2J83_RS14510	COG0564	pseudouridine synthase activity
M2J83_RS14515	COG1530	ribonuclease E activity
M2J83_RS14520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2J83_RS14525	COG0159	tryptophan synthase activity
M2J83_RS14530	COG0133	tryptophan synthase activity
M2J83_RS14535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2J83_RS14545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2J83_RS14550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M2J83_RS14560	COG2878	Part of a membrane complex involved in electron transport
M2J83_RS14565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2J83_RS14570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2J83_RS14575	COG3047	cAMP biosynthetic process
M2J83_RS14600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2J83_RS14605	COG2917	probably involved in intracellular septation
M2J83_RS14615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_RS14620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2J83_RS14630	COG1196	nuclear chromosome segregation
M2J83_RS14640	COG1573	uracil-dna glycosylase
M2J83_RS14645	COG1214	PFAM Peptidase M22, glycoprotease
M2J83_RS14660	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M2J83_RS14665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M2J83_RS14670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2J83_RS14675	COG0560	Phosphoserine phosphatase
M2J83_RS14690	COG1007	ATP synthesis coupled electron transport
M2J83_RS14705	COG0713	ATP synthesis coupled electron transport
M2J83_RS14715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_RS14720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M2J83_RS14725	COG1034	ATP synthesis coupled electron transport
M2J83_RS14740	COG0649	NAD binding
M2J83_RS14745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_RS14750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_RS14755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M2J83_RS14760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS14775	COG0149	triose-phosphate isomerase activity
M2J83_RS14780	COG0604	alcohol dehydrogenase
M2J83_RS14800	COG1185	polyribonucleotide nucleotidyltransferase activity
M2J83_RS14805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2J83_RS14810	COG1183	phosphatidylcholine synthase activity
M2J83_RS14815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M2J83_RS14820	COG0440	acetolactate synthase activity
M2J83_RS14825	COG0028	Belongs to the TPP enzyme family
M2J83_RS14830	COG1289	transmembrane transporter activity
M2J83_RS14835	COG3022	response to hydroperoxide
M2J83_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS14860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2J83_RS14865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2J83_RS14870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M2J83_RS14875	COG1674	ftsk spoiiie
M2J83_RS14880	COG0492	ferredoxin-NADP+ reductase activity
M2J83_RS14900	COG0477	Major facilitator Superfamily
M2J83_RS14920	COG2272	Belongs to the type-B carboxylesterase lipase family
M2J83_RS14925	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS14950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2J83_RS14970	COG2204	response regulator
M2J83_RS15010	COG4964	Belongs to the GSP D family
M2J83_RS15065	COG0612	Peptidase, M16
M2J83_RS15070	COG0484	heat shock protein binding
M2J83_RS15075	COG0443	Heat shock 70 kDa protein
M2J83_RS15080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2J83_RS15085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M2J83_RS15090	COG1420	regulation of RNA biosynthetic process
M2J83_RS15100	COG0497	DNA recombination
M2J83_RS15105	COG0735	belongs to the Fur family
M2J83_RS15110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M2J83_RS15115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M2J83_RS15140	COG0477	Major facilitator Superfamily
M2J83_RS15150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2J83_RS15170	COG0582	viral genome integration into host DNA
M2J83_RS15180	COG1396	sequence-specific DNA binding
M2J83_RS15185	COG0583	DNA-binding transcription factor activity
M2J83_RS15205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2J83_RS15210	COG0633	Ferredoxin
M2J83_RS15215	COG0789	Transcriptional regulator
M2J83_RS15225	COG0640	Transcriptional regulator
M2J83_RS15230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2J83_RS15260	COG1937	Protein conserved in bacteria
M2J83_RS15265	COG2814	Major facilitator Superfamily
M2J83_RS15270	COG1230	cation diffusion facilitator family transporter
M2J83_RS15275	COG0640	Transcriptional regulator
M2J83_RS15285	COG2217	Heavy metal translocating P-type atpase
M2J83_RS15310	COG2814	Major facilitator Superfamily
M2J83_RS15325	COG2814	Major facilitator Superfamily
M2J83_RS15340	COG2186	Transcriptional regulator
M2J83_RS15360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M2J83_RS15410	COG2003	Belongs to the UPF0758 family
M2J83_RS15590	COG0789	Transcriptional regulator
M2J83_RS15630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2J83_RS15640	COG0789	Transcriptional regulator
M2J83_RS15660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2J83_RS15665	COG0629	single-stranded DNA binding
M2J83_RS15730	COG1538	Outer membrane efflux protein
M2J83_RS15760	COG2814	Major facilitator Superfamily
M2J83_RS15770	COG2819	hydrolase of the alpha beta superfamily
M2J83_RS15790	COG1454	alcohol dehydrogenase
M2J83_RS15825	COG1414	Transcriptional regulator
M2J83_RS15830	COG0513	Belongs to the DEAD box helicase family
M2J83_RS15840	COG0583	DNA-binding transcription factor activity
M2J83_RS15845	COG4638	Rieske (2fe-2S)
M2J83_RS15850	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M2J83_RS15865	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2J83_RS15880	COG3971	2-oxopent-4-enoate hydratase activity
M2J83_RS15885	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M2J83_RS15890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M2J83_RS15895	COG2814	Major facilitator Superfamily
M2J83_RS15910	COG0154	amidase activity
M2J83_RS15915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS15920	COG2814	Major facilitator Superfamily
M2J83_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS15965	COG0842	Transport permease protein
M2J83_RS15970	COG0842	Transport permease protein
M2J83_RS15970	COG1129	ABC transporter
M2J83_RS15975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_RS15985	COG3243	poly(R)-hydroxyalkanoic acid synthase
M2J83_RS15995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M2J83_RS16000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M2J83_RS16005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_RS16020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_RS16035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M2J83_RS16040	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M2J83_RS16050	COG0789	Transcriptional regulator
M2J83_RS16060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_RS16105	COG3278	Belongs to the heme-copper respiratory oxidase family
M2J83_RS16110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS16130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2J83_RS16175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_RS16240	COG0516	GMP reductase activity
M2J83_RS16240	COG0517	IMP dehydrogenase activity
M2J83_RS16250	COG1027	Aspartate ammonia-lyase
M2J83_RS16255	COG1846	Transcriptional regulator
M2J83_RS16270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M2J83_RS16275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M2J83_RS16290	COG1414	Transcriptional regulator
M2J83_RS16310	COG0513	Belongs to the DEAD box helicase family
M2J83_RS16330	COG0429	hydrolase of the alpha beta-hydrolase fold
M2J83_RS16355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M2J83_RS16365	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M2J83_RS16375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M2J83_RS16380	COG0632	four-way junction helicase activity
M2J83_RS16390	COG2255	four-way junction helicase activity
M2J83_RS16400	COG0418	dihydroorotase activity
M2J83_RS16410	COG0415	Belongs to the DNA photolyase family
M2J83_RS16475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2J83_RS16480	COG4654	Cytochrome c, class I
M2J83_RS16515	COG1177	transmembrane transport
M2J83_RS16520	COG3842	ATPase activity
M2J83_RS16525	COG1840	ABC-type Fe3 transport system, periplasmic component
M2J83_RS16530	COG2084	Dehydrogenase
M2J83_RS16545	COG0494	nUDIX hydrolase
M2J83_RS16550	COG0442	prolyl-tRNA aminoacylation
M2J83_RS16555	COG0824	Thioesterase
M2J83_RS16560	COG0811	peptide transport
M2J83_RS16575	COG0823	Involved in the tonB-independent uptake of proteins
M2J83_RS16590	COG0596	Alpha beta hydrolase
M2J83_RS16615	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS16620	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2J83_RS16625	COG3845	ABC transporter
M2J83_RS16645	COG0427	acetyl-CoA hydrolase
M2J83_RS16650	COG0583	DNA-binding transcription factor activity
M2J83_RS16655	COG3634	alkyl hydroperoxide reductase activity
M2J83_RS16670	COG0697	spore germination
M2J83_RS16675	COG0175	sulfate reduction
M2J83_RS16685	COG2895	sulfate adenylyltransferase (ATP) activity
M2J83_RS16695	COG1012	belongs to the aldehyde dehydrogenase family
M2J83_RS16700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2J83_RS16705	COG5383	Protein conserved in bacteria
M2J83_RS16715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2J83_RS16730	COG0583	DNA-binding transcription factor activity
M2J83_RS16735	COG1741	Belongs to the pirin family
M2J83_RS16740	COG3706	GGDEF domain
M2J83_RS16745	COG0154	amidase activity
M2J83_RS16760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2J83_RS16770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2J83_RS16775	COG0284	orotidine-5'-phosphate decarboxylase activity
M2J83_RS16790	COG1414	Transcriptional regulator
M2J83_RS16800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2J83_RS16810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2J83_RS16815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M2J83_RS16840	COG0742	ribosomal rna small subunit methyltransferase
M2J83_RS16845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2J83_RS16850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M2J83_RS16880	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M2J83_RS16895	COG1335	isochorismatase
M2J83_RS16900	COG2309	aminopeptidase activity
M2J83_RS16905	COG0596	Alpha beta hydrolase
M2J83_RS16910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_RS16910	COG2010	Cytochrome c
M2J83_RS16915	COG2080	2 iron, 2 sulfur cluster binding
M2J83_RS16920	COG2010	Cytochrome c
M2J83_RS16920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M2J83_RS16935	COG0411	ABC transporter
M2J83_RS16960	COG3706	GGDEF domain
M2J83_RS16975	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS16985	COG1234	tRNA 3'-trailer cleavage
M2J83_RS16990	COG2188	Transcriptional regulator
M2J83_RS17000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2J83_RS17010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M2J83_RS17010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M2J83_RS17015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M2J83_RS17015	COG3608	succinylglutamate desuccinylase aspartoacylase
M2J83_RS17020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M2J83_RS17030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2J83_RS17060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS17085	COG1335	isochorismatase
M2J83_RS17090	COG2309	aminopeptidase activity
M2J83_RS17095	COG0596	Alpha beta hydrolase
M2J83_RS17110	COG1120	ATPase activity
M2J83_RS17115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2J83_RS17125	COG4206	TonB-dependent receptor
M2J83_RS17130	COG2031	fatty acid transporter
M2J83_RS17135	COG0583	DNA-binding transcription factor activity
M2J83_RS17140	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_RS17145	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS17160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M2J83_RS17165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M2J83_RS17170	COG0328	RNA-DNA hybrid ribonuclease activity
M2J83_RS17175	COG2226	methyltransferase
M2J83_RS17180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M2J83_RS17185	COG0741	lytic transglycosylase activity
M2J83_RS17185	COG1388	LysM domain
M2J83_RS17205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M2J83_RS17230	COG2204	response regulator
M2J83_RS17235	COG4191	Histidine kinase
M2J83_RS17240	COG1301	dicarboxylic acid transport
M2J83_RS17250	COG1054	Belongs to the UPF0176 family
M2J83_RS17275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2J83_RS17295	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M2J83_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS17315	COG1877	trehalose-phosphatase activity
M2J83_RS17350	COG0604	alcohol dehydrogenase
M2J83_RS17360	COG1024	Enoyl-CoA hydratase
M2J83_RS17380	COG1902	pentaerythritol trinitrate reductase activity
M2J83_RS17405	COG0583	DNA-binding transcription factor activity
M2J83_RS17425	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M2J83_RS17435	COG0583	DNA-binding transcription factor activity
M2J83_RS17460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS17475	COG1393	Belongs to the ArsC family
M2J83_RS17480	COG0431	NADPH-dependent FMN reductase
M2J83_RS17485	COG0745	RESPONSE REGULATOR receiver
M2J83_RS17490	COG0642	Histidine kinase
M2J83_RS17570	COG2948	multi-organism process
M2J83_RS17605	COG0433	COG0433 Predicted ATPase
M2J83_RS17680	COG0582	viral genome integration into host DNA
M2J83_RS17690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M2J83_RS17690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M2J83_RS17695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2J83_RS17700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2J83_RS17705	COG1881	PFAM PEBP family protein
M2J83_RS17710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2J83_RS17715	COG0739	heme binding
M2J83_RS17720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M2J83_RS17725	COG0316	Belongs to the HesB IscA family
M2J83_RS17735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M2J83_RS17740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2J83_RS17745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2J83_RS17750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS17755	COG0312	modulator of DNA gyrase
M2J83_RS17760	COG3028	Belongs to the UPF0307 family
M2J83_RS17790	COG4566	intracellular signal transduction
M2J83_RS17795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2J83_RS17800	COG0402	S-adenosylhomocysteine deaminase activity
M2J83_RS17805	COG2233	PERMEase
M2J83_RS17810	COG0596	Alpha beta hydrolase
M2J83_RS17810	COG2945	thiolester hydrolase activity
M2J83_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS17830	COG0583	DNA-binding transcription factor activity
M2J83_RS17835	COG4681	YaeQ
M2J83_RS17860	COG0762	integral membrane protein
M2J83_RS17870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2J83_RS17870	COG2169	Transcriptional regulator
M2J83_RS17880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2J83_RS17895	COG0439	Biotin carboxylase
M2J83_RS17900	COG0511	ligase activity, forming carbon-carbon bonds
M2J83_RS17905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M2J83_RS17910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2J83_RS17915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2J83_RS17920	COG3150	esterase
M2J83_RS17935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M2J83_RS17940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2J83_RS17950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M2J83_RS17965	COG1678	Uncharacterized ACR, COG1678
M2J83_RS17980	COG0352	thiamine-phosphate diphosphorylase activity
M2J83_RS17985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M2J83_RS18000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M2J83_RS18010	COG3237	CsbD-like
M2J83_RS18015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2J83_RS18020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2J83_RS18025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2J83_RS18030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M2J83_RS18055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M2J83_RS18070	COG1126	abc transporter atp-binding protein
M2J83_RS18075	COG0765	amino acid transport
M2J83_RS18080	COG4597	amino acid ABC transporter
M2J83_RS18085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2J83_RS18090	COG2884	Cell division ATP-binding protein ftsE
M2J83_RS18095	COG2177	Part of the ABC transporter FtsEX involved in
M2J83_RS18100	COG1194	a g-specific adenine glycosylase
M2J83_RS18105	COG0772	Belongs to the SEDS family
M2J83_RS18110	COG0768	penicillin binding
M2J83_RS18120	COG1792	Involved in formation and maintenance of cell shape
M2J83_RS18125	COG1077	Cell shape determining protein MreB Mrl
M2J83_RS18130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2J83_RS18135	COG0154	amidase activity
M2J83_RS18140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2J83_RS18145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M2J83_RS18150	COG0583	DNA-binding transcription factor activity
M2J83_RS18155	COG2259	Doxx family
M2J83_RS18160	COG3384	dioxygenase
M2J83_RS18170	COG3245	cytochrome
M2J83_RS18185	COG3604	Transcriptional regulator
M2J83_RS18200	COG0786	glutamate:sodium symporter activity
M2J83_RS18205	COG0142	geranyltranstransferase activity
M2J83_RS18215	COG0494	nUDIX hydrolase
M2J83_RS18220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M2J83_RS18245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M2J83_RS18250	COG0237	dephospho-CoA kinase activity
M2J83_RS18265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M2J83_RS18270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2J83_RS18280	COG0477	Major facilitator Superfamily
M2J83_RS18285	COG0259	pyridoxamine-phosphate oxidase activity
M2J83_RS18300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M2J83_RS18335	COG4206	TonB-dependent receptor
M2J83_RS18340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2J83_RS18350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M2J83_RS18370	COG0598	Magnesium transport protein CorA
M2J83_RS18385	COG2022	thiamine diphosphate biosynthetic process
M2J83_RS18390	COG0351	phosphomethylpyrimidine kinase
M2J83_RS18395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2J83_RS18400	COG3344	reverse transcriptase
M2J83_RS18405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M2J83_RS18410	COG1538	Outer membrane efflux protein
M2J83_RS18415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2J83_RS18425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M2J83_RS18440	COG2226	methyltransferase
M2J83_RS18445	COG0745	RESPONSE REGULATOR receiver
M2J83_RS18460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M2J83_RS18465	COG1984	allophanate hydrolase subunit 2
M2J83_RS18470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M2J83_RS18475	COG1238	metal cluster binding
M2J83_RS18500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2J83_RS18505	COG4988	ABC transporter
M2J83_RS18515	COG1294	oxidase, subunit
M2J83_RS18520	COG1271	oxidase subunit
M2J83_RS18535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M2J83_RS18550	COG1137	ATPase activity
M2J83_RS18560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2J83_RS18565	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2J83_RS18570	COG1660	Displays ATPase and GTPase activities
M2J83_RS18580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M2J83_RS18585	COG0792	nuclease activity
M2J83_RS18590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M2J83_RS18605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M2J83_RS18625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M2J83_RS18630	COG0793	Belongs to the peptidase S41A family
M2J83_RS18640	COG0588	phosphoglycerate mutase activity
M2J83_RS18645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2J83_RS18655	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M2J83_RS18660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2J83_RS18665	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS18670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M2J83_RS18675	COG1040	competence protein
M2J83_RS18680	COG2226	methyltransferase
M2J83_RS18685	COG4771	TonB-dependent receptor
M2J83_RS18690	COG0745	RESPONSE REGULATOR receiver
M2J83_RS18700	COG2205	protein histidine kinase activity
M2J83_RS18710	COG2204	response regulator
M2J83_RS18730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M2J83_RS18740	COG3473	Maleate cis-trans isomerase
M2J83_RS18755	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M2J83_RS18785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M2J83_RS18785	COG0662	Cupin 2, conserved barrel domain protein
M2J83_RS18790	COG1215	transferase activity, transferring glycosyl groups
M2J83_RS18800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2J83_RS18815	COG1088	dTDP-glucose 4,6-dehydratase activity
M2J83_RS18820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M2J83_RS18835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2J83_RS18845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2J83_RS18850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2J83_RS18855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2J83_RS18870	COG0356	it plays a direct role in the translocation of protons across the membrane
M2J83_RS18880	COG1024	Enoyl-CoA hydratase
M2J83_RS18895	COG0037	tRNA processing
M2J83_RS18900	COG0163	prenyltransferase activity
M2J83_RS18905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M2J83_RS18910	COG2890	protein-(glutamine-N5) methyltransferase activity
M2J83_RS18960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2J83_RS18990	COG0811	peptide transport
M2J83_RS19005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2J83_RS19010	COG2264	protein methyltransferase activity
M2J83_RS19015	COG4773	Receptor
M2J83_RS19035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2J83_RS19060	COG3180	Ammonia monooxygenase
M2J83_RS19080	COG5002	protein histidine kinase activity
M2J83_RS19095	COG0477	Major facilitator Superfamily
M2J83_RS19100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_RS19120	COG1116	anion transmembrane transporter activity
M2J83_RS19150	COG0437	4 iron, 4 sulfur cluster binding
M2J83_RS19155	COG2864	formate dehydrogenase
M2J83_RS19165	COG1921	L-seryl-tRNASec selenium transferase activity
M2J83_RS19170	COG3276	selenocysteine insertion sequence binding
M2J83_RS19180	COG1476	TRANSCRIPTIONal
M2J83_RS19195	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS19215	COG0709	Synthesizes selenophosphate from selenide and ATP
M2J83_RS19230	COG0583	DNA-binding transcription factor activity
M2J83_RS19235	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M2J83_RS19240	COG0348	domain, Protein
M2J83_RS19240	COG3901	Regulator of nitric oxide reductase transcription
M2J83_RS19245	COG4263	nitrous-oxide reductase activity
M2J83_RS19260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M2J83_RS19275	COG0166	Belongs to the GPI family
M2J83_RS19290	COG1215	transferase activity, transferring glycosyl groups
M2J83_RS19325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M2J83_RS19360	COG0156	8-amino-7-oxononanoate synthase activity
M2J83_RS19365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2J83_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS19370	COG3321	synthase
M2J83_RS19370	COG0604	alcohol dehydrogenase
M2J83_RS19375	COG2233	PERMEase
M2J83_RS19380	COG0697	spore germination
M2J83_RS19385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS19390	COG0697	spore germination
M2J83_RS19410	COG2885	chlorophyll binding
M2J83_RS19505	COG0183	Belongs to the thiolase family
M2J83_RS19510	COG1250	3-hydroxyacyl-CoA dehydrogenase
M2J83_RS19510	COG1024	Enoyl-CoA hydratase
M2J83_RS19525	COG1127	ABC transporter
M2J83_RS19530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M2J83_RS19535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M2J83_RS19550	COG1131	(ABC) transporter
M2J83_RS19555	COG0842	Transport permease protein
M2J83_RS19565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2J83_RS19575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M2J83_RS19580	COG0131	Imidazoleglycerol-phosphate dehydratase
M2J83_RS19590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M2J83_RS19595	COG0107	imidazoleglycerol-phosphate synthase activity
M2J83_RS19605	COG0140	phosphoribosyl-ATP diphosphatase activity
M2J83_RS19610	COG0537	adenosine 5'-monophosphoramidase activity
M2J83_RS19615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M2J83_RS19620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M2J83_RS19630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2J83_RS19640	COG1970	mechanosensitive ion channel activity
M2J83_RS19645	COG0723	plastoquinol--plastocyanin reductase activity
M2J83_RS19650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M2J83_RS19655	COG2857	Cytochrome c1
M2J83_RS19660	COG0625	glutathione transferase activity
M2J83_RS19665	COG2969	positive regulation of protein catabolic process
M2J83_RS19670	COG4208	sulfate ABC transporter
M2J83_RS19675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M2J83_RS19680	COG4150	thiosulfate binding
M2J83_RS19705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M2J83_RS19725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M2J83_RS19730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2J83_RS19745	COG0129	dihydroxy-acid dehydratase activity
M2J83_RS19750	COG1802	Transcriptional regulator
M2J83_RS19755	COG1522	sequence-specific DNA binding
M2J83_RS19765	COG3483	tryptophan 2,3-dioxygenase activity
M2J83_RS19785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M2J83_RS19790	COG0656	L-ascorbic acid biosynthetic process
M2J83_RS19800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M2J83_RS19805	COG3706	GGDEF domain
M2J83_RS19810	COG2226	methyltransferase
M2J83_RS19820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M2J83_RS19835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M2J83_RS19840	COG0583	DNA-binding transcription factor activity
M2J83_RS19845	COG0477	Major facilitator Superfamily
M2J83_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
M2J83_RS19860	COG1335	isochorismatase
M2J83_RS19865	COG1335	isochorismatase
M2J83_RS19885	COG2823	Periplasmic or secreted lipoprotein
M2J83_RS19895	COG3284	Transcriptional regulator
M2J83_RS19925	COG1595	DNA-templated transcription, initiation
M2J83_RS19945	COG1285	pathogenesis
M2J83_RS19960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M2J83_RS20030	COG1522	sequence-specific DNA binding
M2J83_RS20040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M2J83_RS20060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M2J83_RS20100	COG0109	protoheme IX farnesyltransferase activity
M2J83_RS20120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2J83_RS20140	COG3568	Endonuclease Exonuclease Phosphatase
M2J83_RS20145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2J83_RS20170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2J83_RS20180	COG1228	amidohydrolase
M2J83_RS20190	COG2986	histidine ammonia-lyase
M2J83_RS20195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M2J83_RS20225	COG2814	Major facilitator Superfamily
M2J83_RS20235	COG0789	Transcriptional regulator
M2J83_RS20255	COG0625	glutathione transferase activity
M2J83_RS20285	COG2365	Tyrosine phosphatase family
M2J83_RS20290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M2J83_RS20310	COG2423	ornithine cyclodeaminase activity
M2J83_RS20360	COG3069	C4-dicarboxylate transmembrane transporter activity
M2J83_RS20370	COG1802	Transcriptional regulator
M2J83_RS20380	COG2814	Major facilitator Superfamily
M2J83_RS20395	COG2814	Major facilitator Superfamily
M2J83_RS20400	COG0251	oxidation-reduction process
M2J83_RS20405	COG3181	Tripartite tricarboxylate transporter family receptor
M2J83_RS20410	COG0179	Fumarylacetoacetate (FAA) hydrolase
M2J83_RS20415	COG2186	Transcriptional regulator
M2J83_RS20425	COG2814	Major facilitator Superfamily
M2J83_RS20435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M2J83_RS20440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M2J83_RS20445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2J83_RS20465	COG5001	Diguanylate cyclase
M2J83_RS20465	COG5002	protein histidine kinase activity
M2J83_RS20470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M2J83_RS20475	COG1333	cytochrome c biogenesis protein
M2J83_RS20485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2J83_RS20490	COG0113	porphobilinogen synthase activity
M2J83_RS20495	COG4232	protein-disulfide reductase activity
M2J83_RS20515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M2J83_RS20520	COG0203	ribosomal protein L17
M2J83_RS20525	COG0202	RNA polymerase activity
M2J83_RS20530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2J83_RS20535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2J83_RS20540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2J83_RS20545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2J83_RS20555	COG0201	protein transport
M2J83_RS20560	COG0200	Binds to the 23S rRNA
M2J83_RS20565	COG1841	ribosomal large subunit assembly
M2J83_RS20570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2J83_RS20575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M2J83_RS20580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2J83_RS20585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2J83_RS20590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2J83_RS20595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2J83_RS20600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2J83_RS20605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2J83_RS20650	COG1538	Outer membrane efflux protein
M2J83_RS20670	COG0183	Belongs to the thiolase family
M2J83_RS20680	COG2067	long-chain fatty acid transport protein
M2J83_RS20695	COG0318	PFAM AMP-dependent synthetase and ligase
M2J83_RS20700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M2J83_RS20705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M2J83_RS20710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M2J83_RS20710	COG1648	precorrin-2 dehydrogenase activity
M2J83_RS20725	COG1116	anion transmembrane transporter activity
M2J83_RS20730	COG1960	acyl-CoA dehydrogenase activity
M2J83_RS20745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2J83_RS20750	COG0255	Belongs to the universal ribosomal protein uL29 family
M2J83_RS20755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2J83_RS20760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2J83_RS20765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2J83_RS20770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M2J83_RS20775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2J83_RS20780	COG0089	rRNA binding
M2J83_RS20785	COG0088	Forms part of the polypeptide exit tunnel
M2J83_RS20790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2J83_RS20795	COG4175	Glycine betaine
M2J83_RS20800	COG4176	ABC-type proline glycine betaine transport system permease component
M2J83_RS20805	COG0051	transcription antitermination factor activity, RNA binding
M2J83_RS20810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2J83_RS20815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2J83_RS20820	COG0049	tRNA binding
M2J83_RS20825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2J83_RS20855	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M2J83_RS20860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2J83_RS20865	COG0085	RNA polymerase activity
M2J83_RS20870	COG0222	ribosome binding
M2J83_RS20875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2J83_RS20880	COG0081	regulation of translation
M2J83_RS20925	COG1475	DNA binding
M2J83_RS20930	COG1192	Involved in chromosome partitioning
M2J83_RS20935	COG0357	Ribosomal RNA small subunit methyltransferase G
M2J83_RS20940	COG0445	tRNA wobble uridine modification
M2J83_RS20945	COG0436	Aminotransferase
M2J83_RS20955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M2J83_RS20960	COG3706	GGDEF domain
M2J83_RS20965	COG0688	phosphatidylethanolamine metabolic process
M2J83_RS20975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M2J83_RS21015	COG3645	SOS response
M2J83_RS21025	COG3093	addiction module antidote protein HigA
M2J83_RS21050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M2J83_RS21070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2J83_RS21085	COG0582	viral genome integration into host DNA
M2J83_RS21090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2J83_RS21125	COG0753	catalase activity
M2J83_RS21130	COG0706	membrane insertase activity
M2J83_RS21135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2J83_RS21140	COG0594	ribonuclease P activity
M2J83_RS21145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2J83_RS21240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_RS21255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2J83_RS21260	COG3041	Addiction module toxin RelE StbE family
M2J83_RS21265	COG3077	Addiction module antitoxin, RelB DinJ family
M2J83_RS21270	COG1192	Involved in chromosome partitioning