locus-tag	class	description
UZ73_RS00020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UZ73_RS00025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UZ73_RS00110	COG2003	Belongs to the UPF0758 family
UZ73_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS00250	COG3038	cytochrome b561
UZ73_RS00260	COG2353	YceI-like domain
UZ73_RS00265	COG1393	Belongs to the ArsC family
UZ73_RS00270	COG0625	glutathione transferase activity
UZ73_RS00290	COG0084	hydrolase, TatD family'
UZ73_RS00295	COG0470	DNA polymerase III
UZ73_RS00305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UZ73_RS00325	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS00330	COG2914	Belongs to the UPF0125 (RnfH) family
UZ73_RS00335	COG2867	negative regulation of translational initiation
UZ73_RS00340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UZ73_RS00345	COG1252	NADH dehydrogenase
UZ73_RS00370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UZ73_RS00375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UZ73_RS00380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UZ73_RS00390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UZ73_RS00395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UZ73_RS00405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_RS00415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UZ73_RS00420	COG0575	Belongs to the CDS family
UZ73_RS00425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UZ73_RS00430	COG0233	cytoplasmic translational termination
UZ73_RS00435	COG0528	UMP kinase activity
UZ73_RS00440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UZ73_RS00445	COG0052	Belongs to the universal ribosomal protein uS2 family
UZ73_RS00450	COG0024	Methionine aminopeptidase
UZ73_RS00455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
UZ73_RS00480	COG1286	toxin biosynthetic process
UZ73_RS00490	COG0285	dihydrofolate synthase activity
UZ73_RS00495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UZ73_RS00500	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_RS00505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UZ73_RS00520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UZ73_RS00530	COG1999	signal sequence binding
UZ73_RS00535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UZ73_RS00540	COG0640	Transcriptional regulator
UZ73_RS00555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS00560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS00565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS00570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UZ73_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS00580	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS00600	COG0183	Belongs to the thiolase family
UZ73_RS00620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UZ73_RS00630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_RS00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS00640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
UZ73_RS00660	COG0183	Belongs to the thiolase family
UZ73_RS00665	COG0183	Belongs to the thiolase family
UZ73_RS00675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UZ73_RS00710	COG0194	GDP metabolic process
UZ73_RS00715	COG1758	RNA polymerase activity
UZ73_RS00720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UZ73_RS00730	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UZ73_RS00735	COG0739	heme binding
UZ73_RS00740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_RS00745	COG0584	glycerophosphoryl diester phosphodiesterase
UZ73_RS00750	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
UZ73_RS00755	COG1187	pseudouridine synthase activity
UZ73_RS00760	COG3161	chorismate lyase activity
UZ73_RS00765	COG2814	Major facilitator Superfamily
UZ73_RS00770	COG0656	L-ascorbic acid biosynthetic process
UZ73_RS00780	COG0668	transmembrane transport
UZ73_RS00785	COG0165	Argininosuccinate lyase
UZ73_RS00800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS00810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UZ73_RS00820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UZ73_RS00825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UZ73_RS00830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UZ73_RS00835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UZ73_RS00840	COG2252	PERMEase
UZ73_RS00845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_RS00865	COG0488	(ABC) transporter
UZ73_RS00870	COG1619	proteins homologs of microcin C7 resistance protein MccF
UZ73_RS00875	COG0590	tRNA wobble adenosine to inosine editing
UZ73_RS00880	COG1131	(ABC) transporter
UZ73_RS00885	COG0842	Transport permease protein
UZ73_RS00895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS00895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS00900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS00905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS00910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS00920	COG2022	thiamine diphosphate biosynthetic process
UZ73_RS00940	COG1414	Transcriptional regulator
UZ73_RS00950	COG0730	response to heat
UZ73_RS00960	COG1666	GTP binding
UZ73_RS00965	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS00970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UZ73_RS00975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UZ73_RS00975	COG0519	Catalyzes the synthesis of GMP from XMP
UZ73_RS00980	COG2207	Transcriptional regulator
UZ73_RS00990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_RS00995	COG0135	phosphoribosylanthranilate isomerase activity
UZ73_RS01000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS01010	COG0101	tRNA pseudouridine synthase activity
UZ73_RS01020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UZ73_RS01025	COG0473	3-isopropylmalate dehydrogenase activity
UZ73_RS01045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UZ73_RS01055	COG4566	intracellular signal transduction
UZ73_RS01070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UZ73_RS01075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
UZ73_RS01085	COG1295	ribonuclease BN
UZ73_RS01095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UZ73_RS01110	COG1538	Outer membrane efflux protein
UZ73_RS01115	COG1136	(ABC) transporter
UZ73_RS01115	COG0577	efflux transmembrane transporter activity
UZ73_RS01120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS01165	COG4964	Belongs to the GSP D family
UZ73_RS01200	COG3712	iron ion homeostasis
UZ73_RS01205	COG1595	DNA-templated transcription, initiation
UZ73_RS01215	COG4774	siderophore transport
UZ73_RS01220	COG3712	iron ion homeostasis
UZ73_RS01245	COG2959	enzyme of heme biosynthesis
UZ73_RS01255	COG0181	hydroxymethylbilane synthase activity
UZ73_RS01260	COG0861	Integral membrane protein TerC family
UZ73_RS01265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UZ73_RS01270	COG0045	succinate-CoA ligase (ADP-forming) activity
UZ73_RS01280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UZ73_RS01285	COG0583	DNA-binding transcription factor activity
UZ73_RS01290	COG2137	regulation of response to DNA damage stimulus
UZ73_RS01295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UZ73_RS01310	COG0477	Major facilitator Superfamily
UZ73_RS01325	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS01330	COG1024	Enoyl-CoA hydratase
UZ73_RS01335	COG3162	membrane
UZ73_RS01350	COG0540	Belongs to the ATCase OTCase family
UZ73_RS01365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UZ73_RS01370	COG2373	Large extracellular alpha-helical protein
UZ73_RS01380	COG2070	2-Nitropropane dioxygenase
UZ73_RS01390	COG2111	Na H antiporter
UZ73_RS01390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UZ73_RS01395	COG1006	Multisubunit Na H antiporter MnhC subunit
UZ73_RS01400	COG0651	ATP synthesis coupled electron transport
UZ73_RS01410	COG2212	antiporter activity
UZ73_RS01425	COG0477	Major facilitator Superfamily
UZ73_RS01450	COG3158	transport of potassium into the cell
UZ73_RS01455	COG0642	Histidine kinase
UZ73_RS01480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_RS01485	COG4208	sulfate ABC transporter
UZ73_RS01490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_RS01495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UZ73_RS01510	COG1278	Cold shock
UZ73_RS01525	COG1648	precorrin-2 dehydrogenase activity
UZ73_RS01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_RS01530	COG2010	Cytochrome c
UZ73_RS01555	COG0535	radical SAM domain protein
UZ73_RS01565	COG1648	precorrin-2 dehydrogenase activity
UZ73_RS01565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_RS01575	COG2010	Cytochrome c
UZ73_RS01580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS01585	COG0626	cystathionine gamma-synthase activity
UZ73_RS01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UZ73_RS01595	COG0557	exoribonuclease II activity
UZ73_RS01615	COG0765	amino acid transport
UZ73_RS01620	COG0765	amino acid transport
UZ73_RS01625	COG1126	abc transporter atp-binding protein
UZ73_RS01640	COG1850	ribulose-bisphosphate carboxylase activity
UZ73_RS01660	COG2375	cellular response to nickel ion
UZ73_RS01695	COG0583	DNA-binding transcription factor activity
UZ73_RS01700	COG3842	ATPase activity
UZ73_RS01705	COG1175	transmembrane transport
UZ73_RS01710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_RS01715	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_RS01750	COG0412	Dienelactone hydrolase
UZ73_RS01755	COG3530	Putative quorum-sensing-regulated virulence factor
UZ73_RS01760	COG0625	glutathione transferase activity
UZ73_RS01770	COG1741	Belongs to the pirin family
UZ73_RS01780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_RS01785	COG2814	Major facilitator Superfamily
UZ73_RS01790	COG2807	transmembrane transport
UZ73_RS01795	COG2207	Transcriptional regulator
UZ73_RS01800	COG3135	benzoate transporter
UZ73_RS01825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_RS01835	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_RS01845	COG0745	RESPONSE REGULATOR receiver
UZ73_RS01850	COG2205	protein histidine kinase activity
UZ73_RS01865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UZ73_RS01870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
UZ73_RS01875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UZ73_RS01885	COG0330	HflC and HflK could
UZ73_RS01890	COG0330	HflC and HflK could
UZ73_RS01895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UZ73_RS01900	COG1923	regulation of RNA biosynthetic process
UZ73_RS01910	COG1160	GTP binding
UZ73_RS01915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_RS01920	COG2976	Protein conserved in bacteria
UZ73_RS01925	COG0124	histidyl-tRNA synthetase
UZ73_RS01940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UZ73_RS01945	COG0105	UTP biosynthetic process
UZ73_RS01955	COG0583	DNA-binding transcription factor activity
UZ73_RS01960	COG0697	spore germination
UZ73_RS01965	COG0336	Belongs to the RNA methyltransferase TrmD family
UZ73_RS01975	COG0228	four-way junction DNA binding
UZ73_RS01980	COG0425	Belongs to the sulfur carrier protein TusA family
UZ73_RS01985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UZ73_RS02000	COG2351	hydroxyisourate hydrolase activity
UZ73_RS02035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS02060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UZ73_RS02065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UZ73_RS02090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_RS02095	COG0601	transmembrane transport
UZ73_RS02125	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
UZ73_RS02130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UZ73_RS02135	COG0542	response to heat
UZ73_RS02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UZ73_RS02155	COG0348	domain, Protein
UZ73_RS02175	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_RS02185	COG2217	Heavy metal translocating P-type atpase
UZ73_RS02190	COG2224	Isocitrate lyase
UZ73_RS02195	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UZ73_RS02195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UZ73_RS02215	COG1472	Belongs to the glycosyl hydrolase 3 family
UZ73_RS02220	COG0736	holo-[acyl-carrier-protein] synthase activity
UZ73_RS02230	COG2050	protein possibly involved in aromatic compounds catabolism
UZ73_RS02235	COG1024	Enoyl-CoA hydratase
UZ73_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS02245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UZ73_RS02250	COG2151	metal-sulfur cluster biosynthetic enzyme
UZ73_RS02255	COG3396	Phenylacetate-CoA oxygenase
UZ73_RS02260	COG3460	Phenylacetate-CoA oxygenase
UZ73_RS02265	COG3396	Phenylacetate-CoA oxygenase
UZ73_RS02270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
UZ73_RS02275	COG0501	Belongs to the peptidase M48B family
UZ73_RS02280	COG1162	GTPase activity
UZ73_RS02290	COG0335	large ribosomal subunit rRNA binding
UZ73_RS02310	COG0450	alkyl hydroperoxide reductase
UZ73_RS02315	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS02330	COG0123	including yeast histone deacetylase and acetoin utilization protein
UZ73_RS02335	COG2951	lytic endotransglycosylase activity
UZ73_RS02345	COG1555	photosystem II stabilization
UZ73_RS02345	COG1596	polysaccharide export
UZ73_RS02350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_RS02355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UZ73_RS02360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
UZ73_RS02380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UZ73_RS02385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UZ73_RS02390	COG0287	Prephenate dehydrogenase
UZ73_RS02400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UZ73_RS02415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UZ73_RS02435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UZ73_RS02455	COG0753	catalase activity
UZ73_RS02465	COG4335	DNA alkylation repair
UZ73_RS02475	COG0436	Aminotransferase
UZ73_RS02485	COG0251	oxidation-reduction process
UZ73_RS02490	COG1309	transcriptional regulator
UZ73_RS02505	COG0488	(ABC) transporter
UZ73_RS02550	COG3634	alkyl hydroperoxide reductase activity
UZ73_RS02555	COG0625	glutathione transferase activity
UZ73_RS02560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
UZ73_RS02565	COG1280	lysine exporter protein (LysE YggA)
UZ73_RS02585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_RS02595	COG5002	protein histidine kinase activity
UZ73_RS02605	COG2046	Belongs to the sulfate adenylyltransferase family
UZ73_RS02610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UZ73_RS02625	COG0840	transmembrane signaling receptor activity
UZ73_RS02630	COG2119	membrane
UZ73_RS02645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UZ73_RS02650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UZ73_RS02665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UZ73_RS02670	COG2321	neutral zinc metallopeptidase
UZ73_RS02685	COG2175	clavaminate synthase activity
UZ73_RS02690	COG1846	Transcriptional regulator
UZ73_RS02700	COG0347	Belongs to the P(II) protein family
UZ73_RS02705	COG0004	ammonium transporteR
UZ73_RS02710	COG3909	cytochrome
UZ73_RS02720	COG0625	glutathione transferase activity
UZ73_RS02730	COG0657	acetylesterase activity
UZ73_RS02735	COG0730	response to heat
UZ73_RS02740	COG0482	sulfurtransferase activity
UZ73_RS02745	COG0277	FAD linked oxidase domain protein
UZ73_RS02750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UZ73_RS02755	COG2879	small protein
UZ73_RS02760	COG1966	Carbon starvation protein
UZ73_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS02770	COG0765	amino acid transport
UZ73_RS02775	COG0765	amino acid transport
UZ73_RS02780	COG1126	abc transporter atp-binding protein
UZ73_RS02785	COG0028	Belongs to the TPP enzyme family
UZ73_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS02795	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
UZ73_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS02805	COG2226	methyltransferase
UZ73_RS02805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_RS02805	COG0596	Alpha beta hydrolase
UZ73_RS02810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS02815	COG1116	anion transmembrane transporter activity
UZ73_RS02830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS02845	COG5285	phytanoyl-CoA dioxygenase
UZ73_RS02850	COG0662	Cupin 2, conserved barrel domain protein
UZ73_RS02860	COG0456	acetyltransferase
UZ73_RS02865	COG1846	Transcriptional regulator
UZ73_RS02875	COG0312	modulator of DNA gyrase
UZ73_RS02890	COG0308	aminopeptidase N
UZ73_RS02895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
UZ73_RS02910	COG0473	3-isopropylmalate dehydrogenase activity
UZ73_RS02920	COG0433	COG0433 Predicted ATPase
UZ73_RS02925	COG0217	transcriptional regulatory protein
UZ73_RS02930	COG0151	Belongs to the GarS family
UZ73_RS02940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UZ73_RS02945	COG0799	negative regulation of ribosome biogenesis
UZ73_RS02950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UZ73_RS02955	COG0424	maF-like protein
UZ73_RS02975	COG0023	Translation Initiation Factor
UZ73_RS02985	COG2084	Dehydrogenase
UZ73_RS02990	COG0625	glutathione transferase activity
UZ73_RS02995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UZ73_RS03000	COG1047	Peptidyl-prolyl cis-trans
UZ73_RS03005	COG2003	Belongs to the UPF0758 family
UZ73_RS03010	COG1737	Transcriptional regulator
UZ73_RS03015	COG0477	Major facilitator Superfamily
UZ73_RS03025	COG2271	Major facilitator Superfamily
UZ73_RS03040	COG0534	Mate efflux family protein
UZ73_RS03045	COG4175	Glycine betaine
UZ73_RS03050	COG4176	ABC-type proline glycine betaine transport system permease component
UZ73_RS03060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UZ73_RS03065	COG2814	Major facilitator Superfamily
UZ73_RS03070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UZ73_RS03075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UZ73_RS03080	COG0495	leucyl-tRNA aminoacylation
UZ73_RS03090	COG1466	dna polymerase III delta subunit
UZ73_RS03095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UZ73_RS03100	COG1981	membrane
UZ73_RS03115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UZ73_RS03125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
UZ73_RS03130	COG0148	phosphopyruvate hydratase activity
UZ73_RS03140	COG2814	Major facilitator Superfamily
UZ73_RS03155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
UZ73_RS03165	COG0504	CTP synthase activity
UZ73_RS03200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UZ73_RS03210	COG0791	NLP P60 protein
UZ73_RS03220	COG0583	DNA-binding transcription factor activity
UZ73_RS03230	COG0583	DNA-binding transcription factor activity
UZ73_RS03240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UZ73_RS03255	COG1045	serine acetyltransferase
UZ73_RS03270	COG1381	Involved in DNA repair and RecF pathway recombination
UZ73_RS03275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UZ73_RS03280	COG0571	ribonuclease III activity
UZ73_RS03295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UZ73_RS03315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UZ73_RS03320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UZ73_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS03330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UZ73_RS03335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UZ73_RS03345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UZ73_RS03350	COG1399	metal-binding, possibly nucleic acid-binding protein
UZ73_RS03355	COG0424	maF-like protein
UZ73_RS03365	COG3023	N-Acetylmuramoyl-L-alanine amidase
UZ73_RS03370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
UZ73_RS03375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UZ73_RS03380	COG0546	phosphoglycolate phosphatase activity
UZ73_RS03385	COG0564	pseudouridine synthase activity
UZ73_RS03390	COG1530	ribonuclease E activity
UZ73_RS03395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UZ73_RS03400	COG0159	tryptophan synthase activity
UZ73_RS03405	COG0133	tryptophan synthase activity
UZ73_RS03410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UZ73_RS03420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UZ73_RS03425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UZ73_RS03435	COG2878	Part of a membrane complex involved in electron transport
UZ73_RS03440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UZ73_RS03445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UZ73_RS03450	COG3047	cAMP biosynthetic process
UZ73_RS03475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UZ73_RS03480	COG2917	probably involved in intracellular septation
UZ73_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_RS03495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UZ73_RS03505	COG1196	nuclear chromosome segregation
UZ73_RS03515	COG1573	uracil-dna glycosylase
UZ73_RS03520	COG1214	PFAM Peptidase M22, glycoprotease
UZ73_RS03535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UZ73_RS03540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UZ73_RS03545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UZ73_RS03550	COG0560	Phosphoserine phosphatase
UZ73_RS03565	COG1007	ATP synthesis coupled electron transport
UZ73_RS03580	COG0713	ATP synthesis coupled electron transport
UZ73_RS03590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_RS03595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
UZ73_RS03600	COG1034	ATP synthesis coupled electron transport
UZ73_RS03615	COG0649	NAD binding
UZ73_RS03620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_RS03625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_RS03630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UZ73_RS03635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS03650	COG0149	triose-phosphate isomerase activity
UZ73_RS03655	COG0604	alcohol dehydrogenase
UZ73_RS03675	COG1185	polyribonucleotide nucleotidyltransferase activity
UZ73_RS03680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UZ73_RS03685	COG1183	phosphatidylcholine synthase activity
UZ73_RS03690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UZ73_RS03695	COG0440	acetolactate synthase activity
UZ73_RS03700	COG0028	Belongs to the TPP enzyme family
UZ73_RS03705	COG1289	transmembrane transporter activity
UZ73_RS03710	COG3022	response to hydroperoxide
UZ73_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS03740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UZ73_RS03745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UZ73_RS03750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UZ73_RS03755	COG1674	ftsk spoiiie
UZ73_RS03760	COG0492	ferredoxin-NADP+ reductase activity
UZ73_RS03780	COG0477	Major facilitator Superfamily
UZ73_RS03800	COG2272	Belongs to the type-B carboxylesterase lipase family
UZ73_RS03805	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS03830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UZ73_RS03850	COG2204	response regulator
UZ73_RS03890	COG4964	Belongs to the GSP D family
UZ73_RS03950	COG0612	Peptidase, M16
UZ73_RS03955	COG0484	heat shock protein binding
UZ73_RS03960	COG0443	Heat shock 70 kDa protein
UZ73_RS03965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UZ73_RS03970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UZ73_RS03975	COG1420	regulation of RNA biosynthetic process
UZ73_RS03985	COG0497	DNA recombination
UZ73_RS03990	COG0735	belongs to the Fur family
UZ73_RS03995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UZ73_RS04000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UZ73_RS04025	COG0477	Major facilitator Superfamily
UZ73_RS04030	COG1301	dicarboxylic acid transport
UZ73_RS04040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UZ73_RS04075	COG1538	Outer membrane efflux protein
UZ73_RS04095	COG2271	Major facilitator Superfamily
UZ73_RS04110	COG2814	Major facilitator Superfamily
UZ73_RS04120	COG3383	formate dehydrogenase (NAD+) activity
UZ73_RS04120	COG0243	molybdopterin cofactor binding
UZ73_RS04125	COG0437	4 iron, 4 sulfur cluster binding
UZ73_RS04130	COG2864	formate dehydrogenase
UZ73_RS04135	COG3058	Necessary for formate dehydrogenase activity
UZ73_RS04140	COG2819	hydrolase of the alpha beta superfamily
UZ73_RS04160	COG1454	alcohol dehydrogenase
UZ73_RS04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_RS04195	COG1414	Transcriptional regulator
UZ73_RS04200	COG0513	Belongs to the DEAD box helicase family
UZ73_RS04205	COG0583	DNA-binding transcription factor activity
UZ73_RS04210	COG4638	Rieske (2fe-2S)
UZ73_RS04215	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
UZ73_RS04230	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_RS04250	COG4569	acetaldehyde dehydrogenase (acetylating) activity
UZ73_RS04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_RS04260	COG2814	Major facilitator Superfamily
UZ73_RS04280	COG3121	Chaperone
UZ73_RS04290	COG0784	Response regulator, receiver
UZ73_RS04290	COG2205	protein histidine kinase activity
UZ73_RS04295	COG2205	protein histidine kinase activity
UZ73_RS04295	COG0784	Response regulator, receiver
UZ73_RS04300	COG2197	response regulator
UZ73_RS04305	COG2199	diguanylate cyclase activity
UZ73_RS04305	COG2200	EAL domain
UZ73_RS04305	COG2203	Gaf domain
UZ73_RS04315	COG0154	amidase activity
UZ73_RS04320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS04325	COG2814	Major facilitator Superfamily
UZ73_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS04370	COG0842	Transport permease protein
UZ73_RS04375	COG1129	ABC transporter
UZ73_RS04375	COG0842	Transport permease protein
UZ73_RS04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS04390	COG3243	poly(R)-hydroxyalkanoic acid synthase
UZ73_RS04400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
UZ73_RS04405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UZ73_RS04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_RS04430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_RS04445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UZ73_RS04450	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
UZ73_RS04460	COG0789	Transcriptional regulator
UZ73_RS04470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_RS04515	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS04590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_RS04655	COG0517	IMP dehydrogenase activity
UZ73_RS04655	COG0516	GMP reductase activity
UZ73_RS04670	COG1027	Aspartate ammonia-lyase
UZ73_RS04675	COG1846	Transcriptional regulator
UZ73_RS04690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UZ73_RS04695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
UZ73_RS04710	COG1414	Transcriptional regulator
UZ73_RS04730	COG0513	Belongs to the DEAD box helicase family
UZ73_RS04750	COG0429	hydrolase of the alpha beta-hydrolase fold
UZ73_RS04775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_RS04785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
UZ73_RS04795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UZ73_RS04800	COG0632	four-way junction helicase activity
UZ73_RS04810	COG2255	four-way junction helicase activity
UZ73_RS04820	COG0418	dihydroorotase activity
UZ73_RS04830	COG0415	Belongs to the DNA photolyase family
UZ73_RS04885	COG1132	(ABC) transporter
UZ73_RS04910	COG0438	transferase activity, transferring glycosyl groups
UZ73_RS04925	COG0726	polysaccharide deacetylase
UZ73_RS04930	COG0438	transferase activity, transferring glycosyl groups
UZ73_RS04940	COG1643	Atp-dependent helicase
UZ73_RS04945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UZ73_RS04945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UZ73_RS04950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
UZ73_RS04955	COG0659	secondary active sulfate transmembrane transporter activity
UZ73_RS04960	COG2203	Gaf domain
UZ73_RS04960	COG3706	GGDEF domain
UZ73_RS04960	COG4251	negative regulation of phosphorylation
UZ73_RS04960	COG5001	Diguanylate cyclase
UZ73_RS04965	COG0704	Plays a role in the regulation of phosphate uptake
UZ73_RS04970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
UZ73_RS04975	COG1393	Belongs to the ArsC family
UZ73_RS04980	COG1177	transmembrane transport
UZ73_RS04985	COG1176	ABC-type spermidine putrescine transport system, permease component I
UZ73_RS04990	COG3842	ATPase activity
UZ73_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS05020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UZ73_RS05025	COG1562	ergosterol biosynthetic process
UZ73_RS05030	COG1562	ergosterol biosynthetic process
UZ73_RS05040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UZ73_RS05055	COG0436	Aminotransferase
UZ73_RS05065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UZ73_RS05070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UZ73_RS05075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UZ73_RS05085	COG0305	Participates in initiation and elongation during chromosome replication
UZ73_RS05095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UZ73_RS05100	COG2965	DNA replication, synthesis of RNA primer
UZ73_RS05105	COG0360	Binds together with S18 to 16S ribosomal RNA
UZ73_RS05110	COG1469	GTP cyclohydrolase I activity
UZ73_RS05120	COG0142	geranyltranstransferase activity
UZ73_RS05125	COG1722	exodeoxyribonuclease VII activity
UZ73_RS05140	COG0501	Belongs to the peptidase M48B family
UZ73_RS05145	COG0456	acetyltransferase
UZ73_RS05155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UZ73_RS05165	COG1283	sodium-dependent phosphate transmembrane transporter activity
UZ73_RS05185	COG4215	(ABC) transporter
UZ73_RS05190	COG4160	amino acid transport
UZ73_RS05200	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_RS05205	COG1217	gtp-binding protein TYPA
UZ73_RS05210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UZ73_RS05215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UZ73_RS05220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UZ73_RS05225	COG2251	uridine kinase activity
UZ73_RS05225	COG0195	Participates in both transcription termination and antitermination
UZ73_RS05230	COG0779	Required for maturation of 30S ribosomal subunits
UZ73_RS05235	COG1187	pseudouridine synthase activity
UZ73_RS05240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UZ73_RS05265	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
UZ73_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS05275	COG3243	poly(R)-hydroxyalkanoic acid synthase
UZ73_RS05285	COG0564	pseudouridine synthase activity
UZ73_RS05300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS05300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS05310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS05315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS05315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UZ73_RS05330	COG1733	regulation of RNA biosynthetic process
UZ73_RS05340	COG1199	ATP-dependent helicase activity
UZ73_RS05345	COG2183	response to ionizing radiation
UZ73_RS05365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
UZ73_RS05370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UZ73_RS05375	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_RS05380	COG0567	Dehydrogenase, E1 component
UZ73_RS05390	COG0280	phosphate acetyltransferase
UZ73_RS05390	COG0281	malic enzyme
UZ73_RS05395	COG1620	l-lactate permease
UZ73_RS05400	COG2186	Transcriptional regulator
UZ73_RS05405	COG0372	Belongs to the citrate synthase family
UZ73_RS05410	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
UZ73_RS05415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UZ73_RS05420	COG1053	succinate dehydrogenase
UZ73_RS05430	COG2009	succinate dehydrogenase
UZ73_RS05435	COG2188	Transcriptional regulator
UZ73_RS05440	COG0039	L-malate dehydrogenase activity
UZ73_RS05450	COG0477	Major facilitator Superfamily
UZ73_RS05455	COG3829	transcription factor binding
UZ73_RS05485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS05510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UZ73_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS05525	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS05530	COG0183	Belongs to the thiolase family
UZ73_RS05540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS05560	COG1454	alcohol dehydrogenase
UZ73_RS05565	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS05570	COG3284	Transcriptional regulator
UZ73_RS05580	COG4172	Belongs to the ABC transporter superfamily
UZ73_RS05585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_RS05595	COG0747	negative chemotaxis
UZ73_RS05605	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS05610	COG0598	Magnesium transport protein CorA
UZ73_RS05615	COG2363	Small membrane protein
UZ73_RS05620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UZ73_RS05640	COG0655	NAD(P)H dehydrogenase (quinone) activity
UZ73_RS05645	COG0435	Glutathione S-transferase
UZ73_RS05650	COG1304	FMN binding
UZ73_RS05665	COG4773	Receptor
UZ73_RS05695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
UZ73_RS05705	COG3842	ATPase activity
UZ73_RS05710	COG4208	sulfate ABC transporter
UZ73_RS05730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_RS05745	COG0330	HflC and HflK could
UZ73_RS05770	COG0825	malonyl-CoA metabolic process
UZ73_RS05780	COG0215	cysteine-tRNA ligase activity
UZ73_RS05800	COG1968	undecaprenyl-diphosphatase activity
UZ73_RS05805	COG1253	flavin adenine dinucleotide binding
UZ73_RS05810	COG0483	inositol monophosphate 1-phosphatase activity
UZ73_RS05825	COG2031	fatty acid transporter
UZ73_RS05830	COG0154	amidase activity
UZ73_RS05875	COG0668	transmembrane transport
UZ73_RS05885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_RS05895	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS05905	COG1132	(ABC) transporter
UZ73_RS05910	COG0363	glucosamine-6-phosphate deaminase activity
UZ73_RS05915	COG1538	Outer membrane efflux protein
UZ73_RS05920	COG1136	(ABC) transporter
UZ73_RS05920	COG0577	efflux transmembrane transporter activity
UZ73_RS05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS05935	COG3391	amine dehydrogenase activity
UZ73_RS05945	COG2850	peptidyl-arginine hydroxylation
UZ73_RS05950	COG3135	benzoate transporter
UZ73_RS05955	COG2124	cytochrome p450
UZ73_RS05960	COG0156	8-amino-7-oxononanoate synthase activity
UZ73_RS05970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UZ73_RS05985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
UZ73_RS05990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_RS05995	COG1994	Peptidase M50
UZ73_RS06000	COG0009	L-threonylcarbamoyladenylate synthase
UZ73_RS06015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UZ73_RS06020	COG3327	negative regulation of DNA-templated transcription, initiation
UZ73_RS06025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_RS06055	COG1368	sulfuric ester hydrolase activity
UZ73_RS06070	COG2323	membrane
UZ73_RS06075	COG2010	Cytochrome c
UZ73_RS06080	COG1231	oxidoreductase activity
UZ73_RS06130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UZ73_RS06135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UZ73_RS06155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UZ73_RS06160	COG0248	Ppx GppA phosphatase
UZ73_RS06170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UZ73_RS06180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UZ73_RS06185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
UZ73_RS06190	COG1534	Rna-binding protein
UZ73_RS06195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UZ73_RS06200	COG2233	PERMEase
UZ73_RS06225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UZ73_RS06230	COG0505	Belongs to the CarA family
UZ73_RS06235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UZ73_RS06240	COG3391	amine dehydrogenase activity
UZ73_RS06260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS06290	COG1074	ATP-dependent DNA helicase activity
UZ73_RS06305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_RS06310	COG4149	molybdate abc transporter
UZ73_RS06315	COG0725	ABC transporter, periplasmic molybdate-binding protein
UZ73_RS06320	COG4974	Belongs to the 'phage' integrase family
UZ73_RS06325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UZ73_RS06330	COG2223	nitrite transmembrane transporter activity
UZ73_RS06340	COG2910	NAD(P)H-binding
UZ73_RS06345	COG1733	regulation of RNA biosynthetic process
UZ73_RS06370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS06390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_RS06395	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS06400	COG0583	DNA-binding transcription factor activity
UZ73_RS06405	COG0280	phosphate acetyltransferase
UZ73_RS06405	COG0281	malic enzyme
UZ73_RS06410	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS06420	COG0802	atpase or kinase
UZ73_RS06425	COG0860	N-Acetylmuramoyl-L-alanine amidase
UZ73_RS06430	COG0586	Pfam SNARE associated Golgi protein
UZ73_RS06435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UZ73_RS06440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UZ73_RS06445	COG1953	Uracil, thiamine, allantoin
UZ73_RS06450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UZ73_RS06455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UZ73_RS06465	COG0617	tRNA 3'-terminal CCA addition
UZ73_RS06470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UZ73_RS06475	COG1573	uracil-dna glycosylase
UZ73_RS06490	COG2814	Major facilitator Superfamily
UZ73_RS06500	COG1309	transcriptional regulator
UZ73_RS06510	COG1024	Enoyl-CoA hydratase
UZ73_RS06515	COG0752	glycyl-tRNA synthetase alpha subunit
UZ73_RS06520	COG0751	glycine-tRNA ligase activity
UZ73_RS06525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UZ73_RS06530	COG0204	Acyl-transferase
UZ73_RS06545	COG0700	Nucleoside recognition
UZ73_RS06550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UZ73_RS06555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_RS06570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UZ73_RS06580	COG1126	abc transporter atp-binding protein
UZ73_RS06585	COG0765	amino acid transport
UZ73_RS06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS06600	COG2011	ABC-type metal ion transport system permease component
UZ73_RS06605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_RS06620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS06620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UZ73_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS06635	COG1473	amidohydrolase
UZ73_RS06645	COG2239	Acts as a magnesium transporter
UZ73_RS06655	COG0653	protein targeting
UZ73_RS06660	COG0741	lytic transglycosylase activity
UZ73_RS06660	COG1196	nuclear chromosome segregation
UZ73_RS06660	COG0739	heme binding
UZ73_RS06670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
UZ73_RS06685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UZ73_RS06690	COG1181	Belongs to the D-alanine--D-alanine ligase family
UZ73_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UZ73_RS06700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UZ73_RS06710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UZ73_RS06715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UZ73_RS06720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UZ73_RS06730	COG3116	cell division
UZ73_RS06735	COG0275	rRNA processing
UZ73_RS06740	COG2001	Belongs to the MraZ family
UZ73_RS06745	COG0488	(ABC) transporter
UZ73_RS06750	COG0633	Ferredoxin
UZ73_RS06755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UZ73_RS06760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UZ73_RS06765	COG0514	ATP-dependent DNA helicase (RecQ)
UZ73_RS06775	COG0038	chloride channel
UZ73_RS06780	COG1294	oxidase, subunit
UZ73_RS06785	COG1271	oxidase subunit
UZ73_RS06790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UZ73_RS06800	COG2894	cell division
UZ73_RS06805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
UZ73_RS06825	COG0488	(ABC) transporter
UZ73_RS06835	COG1215	transferase activity, transferring glycosyl groups
UZ73_RS06840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UZ73_RS06855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UZ73_RS06865	COG0259	pyridoxamine-phosphate oxidase activity
UZ73_RS06870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_RS06875	COG0579	oxidoreductase
UZ73_RS06885	COG0405	Gamma-glutamyltransferase
UZ73_RS06895	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS06900	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS06900	COG2030	dehydratase
UZ73_RS06905	COG0596	Alpha beta hydrolase
UZ73_RS06910	COG0009	L-threonylcarbamoyladenylate synthase
UZ73_RS06915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UZ73_RS06920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UZ73_RS06925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UZ73_RS06935	COG0521	Mo-molybdopterin cofactor biosynthetic process
UZ73_RS06955	COG0126	phosphoglycerate kinase activity
UZ73_RS06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UZ73_RS06965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UZ73_RS06970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UZ73_RS06975	COG2732	(Barnase) inhibitor
UZ73_RS06985	COG0280	phosphate acetyltransferase
UZ73_RS06985	COG0281	malic enzyme
UZ73_RS06995	COG0436	Aminotransferase
UZ73_RS07005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UZ73_RS07020	COG0477	Major facilitator Superfamily
UZ73_RS07030	COG0154	amidase activity
UZ73_RS07045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_RS07060	COG0583	DNA-binding transcription factor activity
UZ73_RS07075	COG4575	ribosome binding
UZ73_RS07085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UZ73_RS07090	COG2027	D-alanyl-D-alanine carboxypeptidase
UZ73_RS07095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UZ73_RS07100	COG0343	queuine tRNA-ribosyltransferase activity
UZ73_RS07105	COG1862	Preprotein translocase
UZ73_RS07110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UZ73_RS07115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UZ73_RS07130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UZ73_RS07135	COG1702	phosphate starvation-inducible protein PhoH
UZ73_RS07140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UZ73_RS07145	COG4535	Mg2 and Co2 transporter CorC
UZ73_RS07150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UZ73_RS07190	COG2814	Major facilitator Superfamily
UZ73_RS07225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UZ73_RS07230	COG0697	spore germination
UZ73_RS07245	COG0678	peroxiredoxin activity
UZ73_RS07275	COG0315	cyclic pyranopterin monophosphate synthase activity
UZ73_RS07285	COG0314	molybdopterin synthase activity
UZ73_RS07290	COG0521	Mo-molybdopterin cofactor biosynthetic process
UZ73_RS07295	COG0303	'Molybdopterin
UZ73_RS07305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UZ73_RS07310	COG1910	domain protein
UZ73_RS07325	COG3383	formate dehydrogenase (NAD+) activity
UZ73_RS07330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UZ73_RS07370	COG0463	Glycosyl transferase, family 2
UZ73_RS07375	COG2346	COG2346, Truncated hemoglobins
UZ73_RS07380	COG1959	2 iron, 2 sulfur cluster binding
UZ73_RS07385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UZ73_RS07390	COG1858	cytochrome C peroxidase
UZ73_RS07400	COG0411	ABC transporter
UZ73_RS07410	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS07430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UZ73_RS07430	COG2169	Transcriptional regulator
UZ73_RS07440	COG0785	Cytochrome C biogenesis protein
UZ73_RS07445	COG4235	cytochrome complex assembly
UZ73_RS07450	COG3088	subunit of a heme lyase
UZ73_RS07455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_RS07465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
UZ73_RS07485	COG4133	protoheme IX ABC transporter activity
UZ73_RS07495	COG0583	DNA-binding transcription factor activity
UZ73_RS07500	COG0288	reversible hydration of carbon dioxide
UZ73_RS07515	COG0488	(ABC) transporter
UZ73_RS07530	COG0367	asparagine synthase
UZ73_RS07535	COG1024	Enoyl-CoA hydratase
UZ73_RS07625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UZ73_RS07655	COG0582	viral genome integration into host DNA
UZ73_RS07660	COG0012	GTP binding
UZ73_RS07670	COG0193	aminoacyl-tRNA hydrolase activity
UZ73_RS07675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UZ73_RS07680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UZ73_RS07695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
UZ73_RS07705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UZ73_RS07715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_RS07725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
UZ73_RS07730	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_RS07740	COG0277	FAD linked oxidase domain protein
UZ73_RS07750	COG0438	transferase activity, transferring glycosyl groups
UZ73_RS07760	COG0438	transferase activity, transferring glycosyl groups
UZ73_RS07775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UZ73_RS07780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UZ73_RS07790	COG3195	allantoin biosynthetic process
UZ73_RS07790	COG3648	Uricase
UZ73_RS07800	COG0235	Class ii aldolase
UZ73_RS07805	COG1942	4-Oxalocrotonate Tautomerase
UZ73_RS07810	COG2233	PERMEase
UZ73_RS07820	COG0583	DNA-binding transcription factor activity
UZ73_RS07825	COG3960	tartronate-semialdehyde synthase activity
UZ73_RS07830	COG3622	Belongs to the hyi family
UZ73_RS07835	COG2084	Dehydrogenase
UZ73_RS07845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
UZ73_RS07850	COG0469	pyruvate kinase activity
UZ73_RS07855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
UZ73_RS07880	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_RS07885	COG1765	OsmC-like protein
UZ73_RS07890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UZ73_RS07900	COG0509	glycine decarboxylation via glycine cleavage system
UZ73_RS07905	COG2081	HI0933 family
UZ73_RS07930	COG0489	protein tyrosine kinase activity
UZ73_RS07940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_RS07940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_RS07945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UZ73_RS07950	COG0583	DNA-binding transcription factor activity
UZ73_RS07955	COG3257	ureidoglycine aminohydrolase activity
UZ73_RS07960	COG0590	tRNA wobble adenosine to inosine editing
UZ73_RS07965	COG3391	amine dehydrogenase activity
UZ73_RS07975	COG0235	Class ii aldolase
UZ73_RS07980	COG0477	Major facilitator Superfamily
UZ73_RS07995	COG0387	Pfam Sodium calcium exchanger
UZ73_RS08000	COG0583	DNA-binding transcription factor activity
UZ73_RS08025	COG3433	isochorismatase activity
UZ73_RS08025	COG1535	isochorismatase
UZ73_RS08045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UZ73_RS08060	COG1652	LysM domain
UZ73_RS08065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UZ73_RS08080	COG3023	N-Acetylmuramoyl-L-alanine amidase
UZ73_RS08090	COG3128	pkhd-type hydroxylase
UZ73_RS08095	COG4774	siderophore transport
UZ73_RS08100	COG0326	Molecular chaperone. Has ATPase activity
UZ73_RS08125	COG0583	DNA-binding transcription factor activity
UZ73_RS08135	COG0154	amidase activity
UZ73_RS08150	COG0477	Major facilitator Superfamily
UZ73_RS08160	COG4948	Mandelate Racemase Muconate Lactonizing
UZ73_RS08170	COG1418	mRNA catabolic process
UZ73_RS08180	COG2161	toxin-antitoxin pair type II binding
UZ73_RS08190	COG1671	Belongs to the UPF0178 family
UZ73_RS08200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_RS08205	COG0861	Integral membrane protein TerC family
UZ73_RS08230	COG0395	ABC-type sugar transport system, permease component
UZ73_RS08245	COG3842	ATPase activity
UZ73_RS08250	COG1349	DNA-binding transcription factor activity
UZ73_RS08255	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS08290	COG1113	amino acid transport
UZ73_RS08295	COG3844	kynureninase activity
UZ73_RS08300	COG1522	sequence-specific DNA binding
UZ73_RS08305	COG1609	Transcriptional regulator
UZ73_RS08325	COG2186	Transcriptional regulator
UZ73_RS08330	COG1304	FMN binding
UZ73_RS08335	COG0277	FAD linked oxidase domain protein
UZ73_RS08340	COG2375	cellular response to nickel ion
UZ73_RS08340	COG1132	(ABC) transporter
UZ73_RS08345	COG1132	(ABC) transporter
UZ73_RS08350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UZ73_RS08355	COG4605	iron ion homeostasis
UZ73_RS08360	COG4604	ABC transporter, ATP-binding protein
UZ73_RS08365	COG4607	ABC-type enterochelin transport system periplasmic component
UZ73_RS08370	COG4774	siderophore transport
UZ73_RS08380	COG0789	Transcriptional regulator
UZ73_RS08390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS08405	COG1846	Transcriptional regulator
UZ73_RS08425	COG3685	Protein conserved in bacteria
UZ73_RS08435	COG0583	DNA-binding transcription factor activity
UZ73_RS08440	COG2814	Major facilitator Superfamily
UZ73_RS08445	COG0656	L-ascorbic acid biosynthetic process
UZ73_RS08450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS08485	COG0628	permease
UZ73_RS08490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UZ73_RS08505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS08505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS08515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS08525	COG0129	dihydroxy-acid dehydratase activity
UZ73_RS08530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
UZ73_RS08535	COG0730	response to heat
UZ73_RS08540	COG0275	rRNA processing
UZ73_RS08575	COG1950	PFAM Membrane protein of
UZ73_RS08580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UZ73_RS08585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UZ73_RS08595	COG1560	Kdo2-lipid A biosynthetic process
UZ73_RS08600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UZ73_RS08610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
UZ73_RS08615	COG0803	Belongs to the bacterial solute-binding protein 9 family
UZ73_RS08620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UZ73_RS08630	COG0735	belongs to the Fur family
UZ73_RS08635	COG0523	cobalamin synthesis protein
UZ73_RS08645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UZ73_RS08650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UZ73_RS08665	COG2096	Adenosyltransferase
UZ73_RS08680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UZ73_RS08695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UZ73_RS08705	COG1280	lysine exporter protein (LysE YggA)
UZ73_RS08720	COG5295	Hep Hag repeat protein
UZ73_RS08735	COG0251	oxidation-reduction process
UZ73_RS08750	COG1346	cytolysis
UZ73_RS08755	COG2860	membrane
UZ73_RS08760	COG2223	nitrite transmembrane transporter activity
UZ73_RS08770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_RS08780	COG2918	glutathione biosynthetic process
UZ73_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
UZ73_RS08815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS08825	COG1024	Enoyl-CoA hydratase
UZ73_RS08830	COG0070	glutamate synthase
UZ73_RS08830	COG0069	glutamate synthase activity
UZ73_RS08830	COG0067	glutamate synthase
UZ73_RS08845	COG0210	DNA helicase
UZ73_RS08850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UZ73_RS08855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UZ73_RS08880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UZ73_RS08890	COG3391	amine dehydrogenase activity
UZ73_RS08905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UZ73_RS08915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_RS08920	COG0765	amino acid transport
UZ73_RS08925	COG0765	amino acid transport
UZ73_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS08940	COG0583	DNA-binding transcription factor activity
UZ73_RS08950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_RS08955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS08975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_RS09010	COG2311	Membrane
UZ73_RS09020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UZ73_RS09055	COG1253	flavin adenine dinucleotide binding
UZ73_RS09065	COG0583	DNA-binding transcription factor activity
UZ73_RS09075	COG2814	Major facilitator Superfamily
UZ73_RS09080	COG0513	Belongs to the DEAD box helicase family
UZ73_RS09085	COG2819	hydrolase of the alpha beta superfamily
UZ73_RS09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UZ73_RS09095	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
UZ73_RS09130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS09145	COG0683	leucine binding
UZ73_RS09175	COG1021	2,3-dihydroxybenzoate-AMP ligase
UZ73_RS09180	COG1535	isochorismatase
UZ73_RS09180	COG3433	isochorismatase activity
UZ73_RS09185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
UZ73_RS09185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UZ73_RS09200	COG1169	isochorismate synthase
UZ73_RS09205	COG1535	isochorismatase
UZ73_RS09205	COG3433	isochorismatase activity
UZ73_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS09220	COG0840	transmembrane signaling receptor activity
UZ73_RS09230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_RS09235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_RS09240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
UZ73_RS09245	COG2967	ApaG domain
UZ73_RS09250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UZ73_RS09260	COG0546	phosphoglycolate phosphatase activity
UZ73_RS09270	COG0512	Glutamine amidotransferase of anthranilate synthase
UZ73_RS09275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UZ73_RS09280	COG0134	indole-3-glycerol-phosphate synthase activity
UZ73_RS09305	COG3154	lipid carrier protein
UZ73_RS09315	COG0826	peptidase U32
UZ73_RS09365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UZ73_RS09375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UZ73_RS09380	COG1024	Enoyl-CoA hydratase
UZ73_RS09400	COG0321	lipoyl(octanoyl) transferase activity
UZ73_RS09405	COG2921	Belongs to the UPF0250 family
UZ73_RS09415	COG1686	Belongs to the peptidase S11 family
UZ73_RS09425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UZ73_RS09425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UZ73_RS09430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UZ73_RS09435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UZ73_RS09440	COG1278	Cold shock
UZ73_RS09450	COG0859	PFAM glycosyl transferase family 9
UZ73_RS09455	COG0583	DNA-binding transcription factor activity
UZ73_RS09460	COG4336	lyase activity
UZ73_RS09475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS09490	COG0697	spore germination
UZ73_RS09495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UZ73_RS09500	COG0242	peptide deformylase activity
UZ73_RS09505	COG0758	DNA mediated transformation
UZ73_RS09525	COG3712	iron ion homeostasis
UZ73_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS09560	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS09580	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS09585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UZ73_RS09590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UZ73_RS09615	COG0252	asparaginase activity
UZ73_RS09620	COG0564	pseudouridine synthase activity
UZ73_RS09630	COG2358	TRAP transporter, solute receptor (TAXI family
UZ73_RS09655	COG3093	addiction module antidote protein HigA
UZ73_RS09675	COG0583	DNA-binding transcription factor activity
UZ73_RS09705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS09715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS09720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_RS09735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_RS09735	COG3218	ABC-type transport auxiliary lipoprotein component
UZ73_RS09740	COG1127	ABC transporter
UZ73_RS09745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UZ73_RS09775	COG0583	DNA-binding transcription factor activity
UZ73_RS09790	COG0154	amidase activity
UZ73_RS09805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UZ73_RS09820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UZ73_RS09830	COG0513	Belongs to the DEAD box helicase family
UZ73_RS09835	COG1280	lysine exporter protein (LysE YggA)
UZ73_RS09840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UZ73_RS09860	COG0583	DNA-binding transcription factor activity
UZ73_RS09865	COG1335	isochorismatase
UZ73_RS09870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS09880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS09880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UZ73_RS09885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS09890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_RS09895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UZ73_RS09900	COG0066	3-isopropylmalate dehydratase activity
UZ73_RS09905	COG4774	siderophore transport
UZ73_RS09910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UZ73_RS09920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_RS09940	COG0018	arginyl-trna synthetase
UZ73_RS09950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_RS09970	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS09975	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
UZ73_RS09980	COG0183	Belongs to the thiolase family
UZ73_RS09985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UZ73_RS10000	COG2922	Belongs to the Smg family
UZ73_RS10030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS10035	COG0028	Belongs to the TPP enzyme family
UZ73_RS10055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UZ73_RS10065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UZ73_RS10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UZ73_RS10080	COG4149	molybdate abc transporter
UZ73_RS10115	COG0431	NADPH-dependent FMN reductase
UZ73_RS10120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_RS10140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_RS10150	COG1464	Belongs to the NlpA lipoprotein family
UZ73_RS10175	COG2011	ABC-type metal ion transport system permease component
UZ73_RS10180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UZ73_RS10185	COG1464	Belongs to the NlpA lipoprotein family
UZ73_RS10190	COG1464	Belongs to the NlpA lipoprotein family
UZ73_RS10195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UZ73_RS10200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UZ73_RS10205	COG4774	siderophore transport
UZ73_RS10210	COG3712	iron ion homeostasis
UZ73_RS10215	COG1595	DNA-templated transcription, initiation
UZ73_RS10220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UZ73_RS10230	COG0601	transmembrane transport
UZ73_RS10235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_RS10240	COG0444	Belongs to the ABC transporter superfamily
UZ73_RS10245	COG4608	Belongs to the ABC transporter superfamily
UZ73_RS10250	COG1595	DNA-templated transcription, initiation
UZ73_RS10285	COG2207	Transcriptional regulator
UZ73_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS10360	COG4638	Rieske (2fe-2S)
UZ73_RS10370	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
UZ73_RS10375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_RS10380	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_RS10400	COG1846	Transcriptional regulator
UZ73_RS10455	COG0523	cobalamin synthesis protein
UZ73_RS10465	COG0436	Aminotransferase
UZ73_RS10475	COG3842	ATPase activity
UZ73_RS10485	COG0583	DNA-binding transcription factor activity
UZ73_RS10490	COG0697	spore germination
UZ73_RS10500	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS10515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS10520	COG0508	dehydrogenase complex catalyzes the overall conversion of
UZ73_RS10520	COG0596	Alpha beta hydrolase
UZ73_RS10530	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS10545	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS10555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS10565	COG0583	DNA-binding transcription factor activity
UZ73_RS10570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UZ73_RS10590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS10600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS10610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS10620	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS10630	COG2070	2-Nitropropane dioxygenase
UZ73_RS10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UZ73_RS10670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UZ73_RS10675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS10700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS10715	COG1187	pseudouridine synthase activity
UZ73_RS10725	COG0592	DNA-directed DNA polymerase activity
UZ73_RS10730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UZ73_RS10735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UZ73_RS10740	COG0594	ribonuclease P activity
UZ73_RS10745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UZ73_RS10750	COG0706	membrane insertase activity
UZ73_RS10755	COG0753	catalase activity
UZ73_RS10780	COG1335	isochorismatase
UZ73_RS10785	COG2309	aminopeptidase activity
UZ73_RS10790	COG0596	Alpha beta hydrolase
UZ73_RS10810	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS10850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UZ73_RS10895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UZ73_RS10905	COG0688	phosphatidylethanolamine metabolic process
UZ73_RS10910	COG3706	GGDEF domain
UZ73_RS10920	COG0436	Aminotransferase
UZ73_RS10925	COG0445	tRNA wobble uridine modification
UZ73_RS10930	COG0357	Ribosomal RNA small subunit methyltransferase G
UZ73_RS10935	COG1192	Involved in chromosome partitioning
UZ73_RS10940	COG1475	DNA binding
UZ73_RS10965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UZ73_RS10970	COG0051	transcription antitermination factor activity, RNA binding
UZ73_RS10980	COG4176	ABC-type proline glycine betaine transport system permease component
UZ73_RS10985	COG4175	Glycine betaine
UZ73_RS10990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UZ73_RS10995	COG0088	Forms part of the polypeptide exit tunnel
UZ73_RS11000	COG0089	rRNA binding
UZ73_RS11005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UZ73_RS11010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UZ73_RS11015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UZ73_RS11020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UZ73_RS11025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UZ73_RS11030	COG0255	Belongs to the universal ribosomal protein uL29 family
UZ73_RS11035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UZ73_RS11055	COG1116	anion transmembrane transporter activity
UZ73_RS11070	COG1648	precorrin-2 dehydrogenase activity
UZ73_RS11070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UZ73_RS11075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UZ73_RS11080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UZ73_RS11085	COG0318	PFAM AMP-dependent synthetase and ligase
UZ73_RS11110	COG0183	Belongs to the thiolase family
UZ73_RS11115	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS11130	COG1538	Outer membrane efflux protein
UZ73_RS11170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UZ73_RS11175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UZ73_RS11180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UZ73_RS11185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UZ73_RS11190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UZ73_RS11195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UZ73_RS11200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UZ73_RS11205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UZ73_RS11210	COG1841	ribosomal large subunit assembly
UZ73_RS11215	COG0200	Binds to the 23S rRNA
UZ73_RS11220	COG0201	protein transport
UZ73_RS11230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UZ73_RS11235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UZ73_RS11240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UZ73_RS11245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UZ73_RS11250	COG0202	RNA polymerase activity
UZ73_RS11255	COG0203	ribosomal protein L17
UZ73_RS11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_RS11280	COG4232	protein-disulfide reductase activity
UZ73_RS11285	COG0113	porphobilinogen synthase activity
UZ73_RS11290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UZ73_RS11300	COG1333	cytochrome c biogenesis protein
UZ73_RS11305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UZ73_RS11310	COG5002	protein histidine kinase activity
UZ73_RS11310	COG5001	Diguanylate cyclase
UZ73_RS11325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UZ73_RS11330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UZ73_RS11335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UZ73_RS11345	COG2814	Major facilitator Superfamily
UZ73_RS11360	COG3712	iron ion homeostasis
UZ73_RS11365	COG1595	DNA-templated transcription, initiation
UZ73_RS11370	COG1802	Transcriptional regulator
UZ73_RS11375	COG0179	Fumarylacetoacetate (FAA) hydrolase
UZ73_RS11380	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS11385	COG0251	oxidation-reduction process
UZ73_RS11390	COG2814	Major facilitator Superfamily
UZ73_RS11405	COG2814	Major facilitator Superfamily
UZ73_RS11415	COG1802	Transcriptional regulator
UZ73_RS11425	COG3069	C4-dicarboxylate transmembrane transporter activity
UZ73_RS11475	COG2423	ornithine cyclodeaminase activity
UZ73_RS11495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UZ73_RS11500	COG2365	Tyrosine phosphatase family
UZ73_RS11520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UZ73_RS11520	COG1017	nitric oxide dioxygenase activity
UZ73_RS11530	COG0625	glutathione transferase activity
UZ73_RS11560	COG0789	Transcriptional regulator
UZ73_RS11570	COG2814	Major facilitator Superfamily
UZ73_RS11600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UZ73_RS11605	COG2986	histidine ammonia-lyase
UZ73_RS11625	COG1228	amidohydrolase
UZ73_RS11635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS11655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UZ73_RS11660	COG3568	Endonuclease Exonuclease Phosphatase
UZ73_RS11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UZ73_RS11700	COG0109	protoheme IX farnesyltransferase activity
UZ73_RS11735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UZ73_RS11755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UZ73_RS11765	COG1522	sequence-specific DNA binding
UZ73_RS11775	COG1595	DNA-templated transcription, initiation
UZ73_RS11805	COG4774	siderophore transport
UZ73_RS11820	COG3284	Transcriptional regulator
UZ73_RS11830	COG2823	Periplasmic or secreted lipoprotein
UZ73_RS11850	COG1335	isochorismatase
UZ73_RS11855	COG1335	isochorismatase
UZ73_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS11870	COG0477	Major facilitator Superfamily
UZ73_RS11875	COG0583	DNA-binding transcription factor activity
UZ73_RS11880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
UZ73_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_RS11905	COG2226	methyltransferase
UZ73_RS11910	COG3706	GGDEF domain
UZ73_RS11915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UZ73_RS11925	COG0656	L-ascorbic acid biosynthetic process
UZ73_RS11930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UZ73_RS11950	COG3483	tryptophan 2,3-dioxygenase activity
UZ73_RS11955	COG1522	sequence-specific DNA binding
UZ73_RS11960	COG1802	Transcriptional regulator
UZ73_RS11965	COG0129	dihydroxy-acid dehydratase activity
UZ73_RS11980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UZ73_RS11985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS12005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_RS12025	COG4150	thiosulfate binding
UZ73_RS12030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_RS12035	COG4208	sulfate ABC transporter
UZ73_RS12040	COG2969	positive regulation of protein catabolic process
UZ73_RS12045	COG0625	glutathione transferase activity
UZ73_RS12050	COG2857	Cytochrome c1
UZ73_RS12055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UZ73_RS12060	COG0723	plastoquinol--plastocyanin reductase activity
UZ73_RS12065	COG1970	mechanosensitive ion channel activity
UZ73_RS12075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UZ73_RS12085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UZ73_RS12090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UZ73_RS12095	COG0537	adenosine 5'-monophosphoramidase activity
UZ73_RS12100	COG0140	phosphoribosyl-ATP diphosphatase activity
UZ73_RS12110	COG0107	imidazoleglycerol-phosphate synthase activity
UZ73_RS12115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UZ73_RS12125	COG0131	Imidazoleglycerol-phosphate dehydratase
UZ73_RS12130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UZ73_RS12140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UZ73_RS12150	COG0842	Transport permease protein
UZ73_RS12155	COG1131	(ABC) transporter
UZ73_RS12170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_RS12175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UZ73_RS12180	COG1127	ABC transporter
UZ73_RS12195	COG1250	3-hydroxyacyl-CoA dehydrogenase
UZ73_RS12195	COG1024	Enoyl-CoA hydratase
UZ73_RS12200	COG0183	Belongs to the thiolase family
UZ73_RS12295	COG2885	chlorophyll binding
UZ73_RS12315	COG0697	spore germination
UZ73_RS12320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UZ73_RS12325	COG0697	spore germination
UZ73_RS12330	COG2233	PERMEase
UZ73_RS12340	COG0156	8-amino-7-oxononanoate synthase activity
UZ73_RS12375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UZ73_RS12400	COG1215	transferase activity, transferring glycosyl groups
UZ73_RS12415	COG0166	Belongs to the GPI family
UZ73_RS12430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UZ73_RS12445	COG4263	nitrous-oxide reductase activity
UZ73_RS12450	COG3901	Regulator of nitric oxide reductase transcription
UZ73_RS12450	COG0348	domain, Protein
UZ73_RS12455	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UZ73_RS12460	COG0583	DNA-binding transcription factor activity
UZ73_RS12475	COG0709	Synthesizes selenophosphate from selenide and ATP
UZ73_RS12490	COG4771	TonB-dependent receptor
UZ73_RS12500	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS12515	COG1476	TRANSCRIPTIONal
UZ73_RS12525	COG3276	selenocysteine insertion sequence binding
UZ73_RS12530	COG1921	L-seryl-tRNASec selenium transferase activity
UZ73_RS12540	COG2864	formate dehydrogenase
UZ73_RS12545	COG0437	4 iron, 4 sulfur cluster binding
UZ73_RS12550	COG0243	molybdopterin cofactor binding
UZ73_RS12550	COG3383	formate dehydrogenase (NAD+) activity
UZ73_RS12555	COG0243	molybdopterin cofactor binding
UZ73_RS12555	COG3383	formate dehydrogenase (NAD+) activity
UZ73_RS12580	COG1116	anion transmembrane transporter activity
UZ73_RS12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UZ73_RS12605	COG0477	Major facilitator Superfamily
UZ73_RS12620	COG5002	protein histidine kinase activity
UZ73_RS12640	COG3180	Ammonia monooxygenase
UZ73_RS12665	COG4773	Receptor
UZ73_RS12670	COG2264	protein methyltransferase activity
UZ73_RS12675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UZ73_RS12690	COG0811	peptide transport
UZ73_RS12720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UZ73_RS12775	COG0582	viral genome integration into host DNA
UZ73_RS12795	COG2890	protein-(glutamine-N5) methyltransferase activity
UZ73_RS12800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
UZ73_RS12805	COG0163	prenyltransferase activity
UZ73_RS12810	COG0037	tRNA processing
UZ73_RS12825	COG1024	Enoyl-CoA hydratase
UZ73_RS12835	COG0356	it plays a direct role in the translocation of protons across the membrane
UZ73_RS12850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UZ73_RS12855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UZ73_RS12860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UZ73_RS12870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UZ73_RS12905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UZ73_RS12915	COG0438	transferase activity, transferring glycosyl groups
UZ73_RS12920	COG0463	Glycosyl transferase, family 2
UZ73_RS12935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_RS12950	COG3473	Maleate cis-trans isomerase
UZ73_RS12955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UZ73_RS12965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UZ73_RS12985	COG2204	response regulator
UZ73_RS13000	COG0745	RESPONSE REGULATOR receiver
UZ73_RS13005	COG4771	TonB-dependent receptor
UZ73_RS13010	COG2226	methyltransferase
UZ73_RS13015	COG1040	competence protein
UZ73_RS13020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UZ73_RS13025	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS13030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UZ73_RS13035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
UZ73_RS13045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UZ73_RS13050	COG0588	phosphoglycerate mutase activity
UZ73_RS13060	COG0793	Belongs to the peptidase S41A family
UZ73_RS13065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UZ73_RS13085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UZ73_RS13100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UZ73_RS13105	COG0792	nuclease activity
UZ73_RS13110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UZ73_RS13120	COG1660	Displays ATPase and GTPase activities
UZ73_RS13125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
UZ73_RS13130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UZ73_RS13140	COG1137	ATPase activity
UZ73_RS13155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
UZ73_RS13170	COG1271	oxidase subunit
UZ73_RS13175	COG1294	oxidase, subunit
UZ73_RS13185	COG4988	ABC transporter
UZ73_RS13190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UZ73_RS13215	COG1238	metal cluster binding
UZ73_RS13220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UZ73_RS13225	COG1984	allophanate hydrolase subunit 2
UZ73_RS13230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UZ73_RS13245	COG0745	RESPONSE REGULATOR receiver
UZ73_RS13250	COG2226	methyltransferase
UZ73_RS13265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UZ73_RS13275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UZ73_RS13280	COG1538	Outer membrane efflux protein
UZ73_RS13285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UZ73_RS13290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UZ73_RS13295	COG0351	phosphomethylpyrimidine kinase
UZ73_RS13300	COG2022	thiamine diphosphate biosynthetic process
UZ73_RS13320	COG0598	Magnesium transport protein CorA
UZ73_RS13340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS13350	COG1595	DNA-templated transcription, initiation
UZ73_RS13365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UZ73_RS13370	COG4206	TonB-dependent receptor
UZ73_RS13385	COG0477	Major facilitator Superfamily
UZ73_RS13395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
UZ73_RS13400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UZ73_RS13415	COG0237	dephospho-CoA kinase activity
UZ73_RS13420	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
UZ73_RS13445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UZ73_RS13450	COG0494	nUDIX hydrolase
UZ73_RS13460	COG0142	geranyltranstransferase activity
UZ73_RS13465	COG0786	glutamate:sodium symporter activity
UZ73_RS13480	COG3604	Transcriptional regulator
UZ73_RS13495	COG3245	cytochrome
UZ73_RS13505	COG3384	dioxygenase
UZ73_RS13510	COG2259	Doxx family
UZ73_RS13515	COG0583	DNA-binding transcription factor activity
UZ73_RS13520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UZ73_RS13525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UZ73_RS13530	COG0154	amidase activity
UZ73_RS13535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UZ73_RS13540	COG1077	Cell shape determining protein MreB Mrl
UZ73_RS13545	COG1792	Involved in formation and maintenance of cell shape
UZ73_RS13555	COG0768	penicillin binding
UZ73_RS13560	COG0772	Belongs to the SEDS family
UZ73_RS13565	COG1194	a g-specific adenine glycosylase
UZ73_RS13570	COG2177	Part of the ABC transporter FtsEX involved in
UZ73_RS13575	COG2884	Cell division ATP-binding protein ftsE
UZ73_RS13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS13585	COG4597	amino acid ABC transporter
UZ73_RS13590	COG0765	amino acid transport
UZ73_RS13595	COG1126	abc transporter atp-binding protein
UZ73_RS13610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UZ73_RS13635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UZ73_RS13640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UZ73_RS13645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UZ73_RS13650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UZ73_RS13655	COG3237	CsbD-like
UZ73_RS13660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UZ73_RS13675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UZ73_RS13680	COG0352	thiamine-phosphate diphosphorylase activity
UZ73_RS13695	COG1678	Uncharacterized ACR, COG1678
UZ73_RS13710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UZ73_RS13720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UZ73_RS13725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UZ73_RS13740	COG3150	esterase
UZ73_RS13745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UZ73_RS13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UZ73_RS13755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UZ73_RS13760	COG0511	ligase activity, forming carbon-carbon bonds
UZ73_RS13765	COG0439	Biotin carboxylase
UZ73_RS13780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UZ73_RS13790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UZ73_RS13795	COG0762	integral membrane protein
UZ73_RS13820	COG4681	YaeQ
UZ73_RS13825	COG0583	DNA-binding transcription factor activity
UZ73_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS13845	COG0596	Alpha beta hydrolase
UZ73_RS13845	COG2945	thiolester hydrolase activity
UZ73_RS13850	COG2233	PERMEase
UZ73_RS13855	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_RS13865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UZ73_RS13870	COG4566	intracellular signal transduction
UZ73_RS13900	COG3028	Belongs to the UPF0307 family
UZ73_RS13905	COG0312	modulator of DNA gyrase
UZ73_RS13910	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS13915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UZ73_RS13920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UZ73_RS13925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UZ73_RS13935	COG0316	Belongs to the HesB IscA family
UZ73_RS13940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
UZ73_RS13945	COG0739	heme binding
UZ73_RS13950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UZ73_RS13955	COG1881	PFAM PEBP family protein
UZ73_RS13960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UZ73_RS13965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UZ73_RS13970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UZ73_RS13970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UZ73_RS13990	COG0642	Histidine kinase
UZ73_RS13995	COG0745	RESPONSE REGULATOR receiver
UZ73_RS14000	COG0431	NADPH-dependent FMN reductase
UZ73_RS14005	COG1393	Belongs to the ArsC family
UZ73_RS14020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS14045	COG0583	DNA-binding transcription factor activity
UZ73_RS14050	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
UZ73_RS14065	COG1454	alcohol dehydrogenase
UZ73_RS14070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UZ73_RS14075	COG0583	DNA-binding transcription factor activity
UZ73_RS14095	COG1902	pentaerythritol trinitrate reductase activity
UZ73_RS14120	COG4804	nuclease activity
UZ73_RS14125	COG2003	Belongs to the UPF0758 family
UZ73_RS14135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
UZ73_RS14185	COG1192	Involved in chromosome partitioning
UZ73_RS14200	COG4959	Type IV secretory pathway protease TraF
UZ73_RS14215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UZ73_RS14220	COG0583	DNA-binding transcription factor activity
UZ73_RS14240	COG4962	Type ii secretion system protein e
UZ73_RS14245	COG3838	Conjugal transfer protein Trbc
UZ73_RS14255	COG3451	type IV secretory pathway VirB4
UZ73_RS14270	COG3846	protein secretion by the type IV secretion system
UZ73_RS14295	COG1024	Enoyl-CoA hydratase
UZ73_RS14305	COG0604	alcohol dehydrogenase
UZ73_RS14340	COG1877	trehalose-phosphatase activity
UZ73_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS14360	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
UZ73_RS14375	COG2204	response regulator
UZ73_RS14380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UZ73_RS14405	COG1054	Belongs to the UPF0176 family
UZ73_RS14415	COG1301	dicarboxylic acid transport
UZ73_RS14420	COG4191	Histidine kinase
UZ73_RS14425	COG2204	response regulator
UZ73_RS14450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UZ73_RS14470	COG0741	lytic transglycosylase activity
UZ73_RS14470	COG1388	LysM domain
UZ73_RS14475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UZ73_RS14480	COG2226	methyltransferase
UZ73_RS14485	COG0328	RNA-DNA hybrid ribonuclease activity
UZ73_RS14490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UZ73_RS14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UZ73_RS14510	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS14515	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_RS14520	COG0583	DNA-binding transcription factor activity
UZ73_RS14525	COG2031	fatty acid transporter
UZ73_RS14530	COG4206	TonB-dependent receptor
UZ73_RS14540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UZ73_RS14545	COG1120	ATPase activity
UZ73_RS14560	COG0596	Alpha beta hydrolase
UZ73_RS14565	COG2309	aminopeptidase activity
UZ73_RS14570	COG1335	isochorismatase
UZ73_RS14595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UZ73_RS14625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS14635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS14640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UZ73_RS14640	COG3608	succinylglutamate desuccinylase aspartoacylase
UZ73_RS14645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UZ73_RS14645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UZ73_RS14655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UZ73_RS14665	COG2188	Transcriptional regulator
UZ73_RS14670	COG1234	tRNA 3'-trailer cleavage
UZ73_RS14690	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS14730	COG0411	ABC transporter
UZ73_RS14745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_RS14745	COG2010	Cytochrome c
UZ73_RS14750	COG2080	2 iron, 2 sulfur cluster binding
UZ73_RS14755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UZ73_RS14755	COG2010	Cytochrome c
UZ73_RS14760	COG0596	Alpha beta hydrolase
UZ73_RS14765	COG2309	aminopeptidase activity
UZ73_RS14770	COG1335	isochorismatase
UZ73_RS14785	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UZ73_RS14815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UZ73_RS14820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UZ73_RS14825	COG0742	ribosomal rna small subunit methyltransferase
UZ73_RS14850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UZ73_RS14855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UZ73_RS14865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UZ73_RS14875	COG1414	Transcriptional regulator
UZ73_RS14890	COG0284	orotidine-5'-phosphate decarboxylase activity
UZ73_RS14895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UZ73_RS14905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UZ73_RS14915	COG1595	DNA-templated transcription, initiation
UZ73_RS14920	COG3712	iron ion homeostasis
UZ73_RS14930	COG0154	amidase activity
UZ73_RS14935	COG3706	GGDEF domain
UZ73_RS14940	COG1741	Belongs to the pirin family
UZ73_RS14945	COG0583	DNA-binding transcription factor activity
UZ73_RS14960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UZ73_RS14965	COG2895	sulfate adenylyltransferase (ATP) activity
UZ73_RS14975	COG0175	sulfate reduction
UZ73_RS14980	COG0697	spore germination
UZ73_RS14995	COG3634	alkyl hydroperoxide reductase activity
UZ73_RS15000	COG0583	DNA-binding transcription factor activity
UZ73_RS15005	COG0427	acetyl-CoA hydrolase
UZ73_RS15025	COG3845	ABC transporter
UZ73_RS15030	COG4603	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS15035	COG1079	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS15060	COG0596	Alpha beta hydrolase
UZ73_RS15075	COG0823	Involved in the tonB-independent uptake of proteins
UZ73_RS15090	COG0811	peptide transport
UZ73_RS15095	COG0824	Thioesterase
UZ73_RS15100	COG0442	prolyl-tRNA aminoacylation
UZ73_RS15105	COG0494	nUDIX hydrolase
UZ73_RS15120	COG2084	Dehydrogenase
UZ73_RS15125	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_RS15130	COG3842	ATPase activity
UZ73_RS15135	COG1177	transmembrane transport
UZ73_RS15170	COG4654	Cytochrome c, class I
UZ73_RS15175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UZ73_RS15230	COG2186	Transcriptional regulator
UZ73_RS15235	COG0277	FAD linked oxidase domain protein
UZ73_RS15240	COG0277	FAD linked oxidase domain protein
UZ73_RS15245	COG0247	lactate metabolic process
UZ73_RS15285	COG1283	sodium-dependent phosphate transmembrane transporter activity
UZ73_RS15300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UZ73_RS15310	COG0697	spore germination
UZ73_RS15330	COG3094	Invasion gene expression up-regulator, SirB
UZ73_RS15340	COG0640	Transcriptional regulator
UZ73_RS15365	COG0659	secondary active sulfate transmembrane transporter activity
UZ73_RS15370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_RS15380	COG2314	TM2 domain
UZ73_RS15385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UZ73_RS15390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UZ73_RS15395	COG0791	NLP P60 protein
UZ73_RS15415	COG1360	Flagellar Motor Protein
UZ73_RS15425	COG0835	chemotaxis
UZ73_RS15430	COG0840	transmembrane signaling receptor activity
UZ73_RS15435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UZ73_RS15445	COG0745	RESPONSE REGULATOR receiver
UZ73_RS15450	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
UZ73_RS15460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UZ73_RS15485	COG1815	bacterial-type flagellum-dependent cell motility
UZ73_RS15490	COG1558	bacterial-type flagellum-dependent cell motility
UZ73_RS15495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UZ73_RS15535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UZ73_RS15560	COG2176	DNA-directed DNA polymerase activity
UZ73_RS15570	COG1987	bacterial-type flagellum assembly
UZ73_RS15585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UZ73_RS15610	COG1157	protein secretion by the type III secretion system
UZ73_RS15625	COG1766	The M ring may be actively involved in energy transduction
UZ73_RS15630	COG1677	Flagellar hook-basal body complex protein FliE
UZ73_RS15635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UZ73_RS15660	COG1334	flagellar protein FlaG
UZ73_RS15665	COG1191	sigma factor activity
UZ73_RS15720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_RS15740	COG2733	membrane
UZ73_RS15745	COG0840	transmembrane signaling receptor activity
UZ73_RS15750	COG0840	transmembrane signaling receptor activity
UZ73_RS15775	COG2610	gluconate transmembrane transporter activity
UZ73_RS15790	COG4521	taurine ABC transporter
UZ73_RS15795	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
UZ73_RS15800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UZ73_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS15810	COG0583	DNA-binding transcription factor activity
UZ73_RS15840	COG2824	Alkylphosphonate utilization operon protein PhnA
UZ73_RS15855	COG4771	TonB-dependent receptor
UZ73_RS15860	COG1858	cytochrome C peroxidase
UZ73_RS15870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UZ73_RS15900	COG1113	amino acid transport
UZ73_RS15920	COG0583	DNA-binding transcription factor activity
UZ73_RS15925	COG3755	Protein conserved in bacteria
UZ73_RS15930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UZ73_RS15970	COG0446	pyridine nucleotide-disulphide oxidoreductase
UZ73_RS15995	COG1278	Cold shock
UZ73_RS16000	COG0642	Histidine kinase
UZ73_RS16010	COG3278	Belongs to the heme-copper respiratory oxidase family
UZ73_RS16020	COG2863	cytochrome
UZ73_RS16025	COG3258	Cytochrome c
UZ73_RS16055	COG0025	NhaP-type Na H and K H
UZ73_RS16070	COG1289	transmembrane transporter activity
UZ73_RS16075	COG2252	PERMEase
UZ73_RS16095	COG1999	signal sequence binding
UZ73_RS16105	COG0069	glutamate synthase activity
UZ73_RS16115	COG1846	Transcriptional regulator
UZ73_RS16125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UZ73_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS16175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
UZ73_RS16175	COG3264	Mechanosensitive ion channel
UZ73_RS16180	COG3264	Mechanosensitive ion channel
UZ73_RS16180	COG1511	domain protein
UZ73_RS16185	COG0477	Major facilitator Superfamily
UZ73_RS16200	COG1396	sequence-specific DNA binding
UZ73_RS16205	COG3437	response regulator, receiver
UZ73_RS16210	COG2205	protein histidine kinase activity
UZ73_RS16210	COG2198	Histidine kinase
UZ73_RS16210	COG0784	Response regulator, receiver
UZ73_RS16215	COG2239	Acts as a magnesium transporter
UZ73_RS16225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UZ73_RS16230	COG1490	D-aminoacyl-tRNA deacylase activity
UZ73_RS16245	COG0456	acetyltransferase
UZ73_RS16255	COG0501	Belongs to the peptidase M48B family
UZ73_RS16260	COG2814	Major facilitator Superfamily
UZ73_RS16270	COG4115	mRNA cleavage
UZ73_RS16275	COG2161	toxin-antitoxin pair type II binding
UZ73_RS16395	COG3772	lysozyme
UZ73_RS16445	COG3706	GGDEF domain
UZ73_RS16460	COG1522	sequence-specific DNA binding
UZ73_RS16465	COG0626	cystathionine gamma-synthase activity
UZ73_RS16475	COG0494	nUDIX hydrolase
UZ73_RS16480	COG2832	Protein of unknown function (DUF454)
UZ73_RS16490	COG0137	argininosuccinate synthase activity
UZ73_RS16495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UZ73_RS16500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UZ73_RS16520	COG1609	Transcriptional regulator
UZ73_RS16525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UZ73_RS16535	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UZ73_RS16540	COG2205	protein histidine kinase activity
UZ73_RS16545	COG0745	RESPONSE REGULATOR receiver
UZ73_RS16550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UZ73_RS16560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_RS16565	COG0268	Binds directly to 16S ribosomal RNA
UZ73_RS16570	COG0728	peptidoglycan biosynthetic process
UZ73_RS16580	COG0563	adenylate kinase activity
UZ73_RS16585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UZ73_RS16590	COG2835	tetraacyldisaccharide 4'-kinase activity
UZ73_RS16595	COG1663	tetraacyldisaccharide 4'-kinase activity
UZ73_RS16600	COG0848	biopolymer transport protein
UZ73_RS16605	COG0811	peptide transport
UZ73_RS16610	COG1570	exodeoxyribonuclease VII activity
UZ73_RS16615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UZ73_RS16625	COG0183	Belongs to the thiolase family
UZ73_RS16635	COG1278	Cold shock
UZ73_RS16640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
UZ73_RS16645	COG0542	response to heat
UZ73_RS16650	COG2995	paraquat-inducible protein a
UZ73_RS16655	COG3008	intermembrane lipid transfer
UZ73_RS16655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UZ73_RS16675	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS16705	COG0300	oxidoreductase activity
UZ73_RS16715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
UZ73_RS16720	COG0756	dUTP diphosphatase activity
UZ73_RS16730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UZ73_RS16735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UZ73_RS16740	COG0196	riboflavin kinase activity
UZ73_RS16745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UZ73_RS16750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UZ73_RS16750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UZ73_RS16760	COG0210	DNA helicase
UZ73_RS16815	COG0488	(ABC) transporter
UZ73_RS16820	COG2890	protein-(glutamine-N5) methyltransferase activity
UZ73_RS16825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UZ73_RS16830	COG2171	N-acyltransferase activity
UZ73_RS16840	COG2207	Transcriptional regulator
UZ73_RS16850	COG0471	metal ion transport
UZ73_RS16850	COG3273	potassium ion transport
UZ73_RS16900	COG0789	Transcriptional regulator
UZ73_RS16920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS16925	COG0544	peptidyl-prolyl cis-trans isomerase activity
UZ73_RS16930	COG0740	serine-type endopeptidase activity
UZ73_RS16940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UZ73_RS16960	COG0556	nucleotide-excision repair
UZ73_RS16965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UZ73_RS16975	COG1104	cysteine desulfurase activity
UZ73_RS16980	COG0822	iron-sulfur transferase activity
UZ73_RS16985	COG0316	Belongs to the HesB IscA family
UZ73_RS17000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UZ73_RS17005	COG4221	oxidoreductase activity
UZ73_RS17010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UZ73_RS17020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UZ73_RS17025	COG0697	spore germination
UZ73_RS17030	COG0385	Bile acid
UZ73_RS17040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UZ73_RS17055	COG1136	(ABC) transporter
UZ73_RS17060	COG0084	hydrolase, TatD family'
UZ73_RS17075	COG0613	PHP domain protein
UZ73_RS17085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UZ73_RS17085	COG0047	phosphoribosylformylglycinamidine synthase activity
UZ73_RS17110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UZ73_RS17110	COG0519	Catalyzes the synthesis of GMP from XMP
UZ73_RS17115	COG1595	DNA-templated transcription, initiation
UZ73_RS17135	COG3971	2-oxopent-4-enoate hydratase activity
UZ73_RS17140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UZ73_RS17155	COG0583	DNA-binding transcription factor activity
UZ73_RS17170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UZ73_RS17180	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS17185	COG0523	cobalamin synthesis protein
UZ73_RS17190	COG1469	GTP cyclohydrolase I activity
UZ73_RS17205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UZ73_RS17210	COG0735	belongs to the Fur family
UZ73_RS17215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UZ73_RS17245	COG0745	RESPONSE REGULATOR receiver
UZ73_RS17250	COG2207	Transcriptional regulator
UZ73_RS17265	COG0494	nUDIX hydrolase
UZ73_RS17270	COG0583	DNA-binding transcription factor activity
UZ73_RS17275	COG1289	transmembrane transporter activity
UZ73_RS17295	COG1942	4-Oxalocrotonate Tautomerase
UZ73_RS17310	COG3162	membrane
UZ73_RS17315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UZ73_RS17325	COG2070	2-Nitropropane dioxygenase
UZ73_RS17360	COG1309	transcriptional regulator
UZ73_RS17385	COG2816	NAD+ diphosphatase activity
UZ73_RS17390	COG0625	glutathione transferase activity
UZ73_RS17395	COG0740	serine-type endopeptidase activity
UZ73_RS17450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UZ73_RS17460	COG1960	acyl-CoA dehydrogenase activity
UZ73_RS17490	COG0640	Transcriptional regulator
UZ73_RS17515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UZ73_RS17540	COG3485	protocatechuate 3,4-dioxygenase
UZ73_RS17550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UZ73_RS17555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UZ73_RS17565	COG3135	benzoate transporter
UZ73_RS17570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UZ73_RS17575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UZ73_RS17585	COG4555	ABC transporter
UZ73_RS17595	COG2197	response regulator
UZ73_RS17600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UZ73_RS17625	COG1846	Transcriptional regulator
UZ73_RS17630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_RS17635	COG2271	Major facilitator Superfamily
UZ73_RS17645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UZ73_RS17655	COG0697	spore germination
UZ73_RS17680	COG3842	ATPase activity
UZ73_RS17695	COG2205	protein histidine kinase activity
UZ73_RS17710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UZ73_RS17715	COG0667	Aldo Keto reductase
UZ73_RS17740	COG2135	peptidase activity
UZ73_RS17775	COG1272	protein, Hemolysin III
UZ73_RS17795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UZ73_RS17800	COG0765	amino acid transport
UZ73_RS17805	COG0765	amino acid transport
UZ73_RS17810	COG1126	abc transporter atp-binding protein
UZ73_RS17860	COG2871	sodium ion transport
UZ73_RS17890	COG2814	Major facilitator Superfamily
UZ73_RS17895	COG1280	lysine exporter protein (LysE YggA)
UZ73_RS17915	COG0402	S-adenosylhomocysteine deaminase activity
UZ73_RS17940	COG0330	HflC and HflK could
UZ73_RS17945	COG1585	Membrane protein implicated in regulation of membrane protease activity
UZ73_RS17950	COG2226	methyltransferase
UZ73_RS17960	COG3042	response to heat
UZ73_RS17970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UZ73_RS17985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UZ73_RS17990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UZ73_RS18005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UZ73_RS18010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UZ73_RS18050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UZ73_RS18055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UZ73_RS18060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UZ73_RS18065	COG0072	phenylalanine-tRNA ligase activity
UZ73_RS18065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UZ73_RS18080	COG2833	Protein of unknown function (DUF455)
UZ73_RS18095	COG5265	(ABC) transporter
UZ73_RS18100	COG1959	2 iron, 2 sulfur cluster binding
UZ73_RS18105	COG0719	Fe-S assembly protein
UZ73_RS18110	COG0396	ATPase activity
UZ73_RS18115	COG0719	Fe-S assembly protein
UZ73_RS18125	COG0822	iron-sulfur transferase activity
UZ73_RS18130	COG2151	metal-sulfur cluster biosynthetic enzyme
UZ73_RS18150	COG1538	Outer membrane efflux protein
UZ73_RS18185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UZ73_RS18190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UZ73_RS18195	COG1181	Belongs to the D-alanine--D-alanine ligase family
UZ73_RS18215	COG0747	negative chemotaxis
UZ73_RS18220	COG0601	transmembrane transport
UZ73_RS18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UZ73_RS18230	COG4172	Belongs to the ABC transporter superfamily
UZ73_RS18240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UZ73_RS18285	COG0604	alcohol dehydrogenase
UZ73_RS18290	COG2207	Transcriptional regulator
UZ73_RS18295	COG3048	D-serine ammonia-lyase activity
UZ73_RS18300	COG3258	Cytochrome c
UZ73_RS18315	COG3949	Membrane
UZ73_RS18330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UZ73_RS18345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UZ73_RS18350	COG0569	domain protein
UZ73_RS18355	COG1902	pentaerythritol trinitrate reductase activity
UZ73_RS18365	COG1610	YqeY-like protein
UZ73_RS18370	COG0587	DNA-directed DNA polymerase activity
UZ73_RS18405	COG3181	Tripartite tricarboxylate transporter family receptor
UZ73_RS18410	COG0583	DNA-binding transcription factor activity
UZ73_RS18415	COG1686	Belongs to the peptidase S11 family
UZ73_RS18430	COG1360	Flagellar Motor Protein
UZ73_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS18445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UZ73_RS18450	COG4221	oxidoreductase activity
UZ73_RS18455	COG0307	riboflavin synthase, alpha
UZ73_RS18500	COG2233	PERMEase
UZ73_RS18505	COG0071	Belongs to the small heat shock protein (HSP20) family
UZ73_RS18510	COG1473	amidohydrolase
UZ73_RS18550	COG2816	NAD+ diphosphatase activity
UZ73_RS18555	COG1561	YicC-like family, N-terminal region
UZ73_RS18570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UZ73_RS18575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UZ73_RS18580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UZ73_RS18585	COG0174	glutamine synthetase
UZ73_RS18590	COG2153	protein acetylation
UZ73_RS18610	COG3842	ATPase activity
UZ73_RS18615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UZ73_RS18620	COG1840	ABC-type Fe3 transport system, periplasmic component
UZ73_RS18635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UZ73_RS18645	COG0783	Belongs to the Dps family
UZ73_RS18655	COG3842	ATPase activity
UZ73_RS18660	COG0395	ABC-type sugar transport system, permease component
UZ73_RS18665	COG1175	transmembrane transport
UZ73_RS18670	COG1653	transport
UZ73_RS18685	COG0559	Belongs to the binding-protein-dependent transport system permease family
UZ73_RS18705	COG0625	glutathione transferase activity
UZ73_RS18715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UZ73_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
UZ73_RS18730	COG0114	fumarate hydratase activity
UZ73_RS18735	COG2133	pyrroloquinoline quinone binding
UZ73_RS18740	COG2226	methyltransferase
UZ73_RS18745	COG0589	response to stress
UZ73_RS18750	COG4654	Cytochrome c, class I
UZ73_RS18755	COG2207	Transcriptional regulator
UZ73_RS18770	COG1012	belongs to the aldehyde dehydrogenase family
UZ73_RS18775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UZ73_RS18780	COG2807	transmembrane transport
UZ73_RS18790	COG0583	DNA-binding transcription factor activity
UZ73_RS18820	COG0583	DNA-binding transcription factor activity
UZ73_RS18825	COG4974	Belongs to the 'phage' integrase family
UZ73_RS18835	COG2132	Multicopper oxidase
UZ73_RS18840	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
UZ73_RS19000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UZ73_RS19045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UZ73_RS19060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UZ73_RS19065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UZ73_RS19070	COG0049	tRNA binding
UZ73_RS19075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UZ73_RS19105	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
UZ73_RS19110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UZ73_RS19115	COG0085	RNA polymerase activity
UZ73_RS19120	COG0222	ribosome binding
UZ73_RS19125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UZ73_RS19135	COG0081	regulation of translation