locus-tag	class	description
CLH39_RS00045	COG3391	amine dehydrogenase activity
CLH39_RS00065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS00070	COG0028	Belongs to the TPP enzyme family
CLH39_RS00090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS00100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLH39_RS00105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CLH39_RS00115	COG4149	molybdate abc transporter
CLH39_RS00150	COG0431	NADPH-dependent FMN reductase
CLH39_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_RS00170	COG1464	Belongs to the NlpA lipoprotein family
CLH39_RS00195	COG2011	ABC-type metal ion transport system permease component
CLH39_RS00200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLH39_RS00205	COG1464	Belongs to the NlpA lipoprotein family
CLH39_RS00210	COG1464	Belongs to the NlpA lipoprotein family
CLH39_RS00225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLH39_RS00230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLH39_RS00240	COG0601	transmembrane transport
CLH39_RS00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_RS00250	COG0444	Belongs to the ABC transporter superfamily
CLH39_RS00255	COG4608	Belongs to the ABC transporter superfamily
CLH39_RS00260	COG1595	DNA-templated transcription, initiation
CLH39_RS00290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_RS00305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS00370	COG4638	Rieske (2fe-2S)
CLH39_RS00380	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLH39_RS00385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_RS00390	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_RS00410	COG1846	Transcriptional regulator
CLH39_RS00465	COG0523	cobalamin synthesis protein
CLH39_RS00470	COG0697	spore germination
CLH39_RS00480	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS00495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS00500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_RS00500	COG0596	Alpha beta hydrolase
CLH39_RS00510	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_RS00525	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS00545	COG2271	Major facilitator Superfamily
CLH39_RS00550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS00555	COG1802	Transcriptional regulator
CLH39_RS00560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS00570	COG0583	DNA-binding transcription factor activity
CLH39_RS00575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLH39_RS00595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS00600	COG2186	Transcriptional regulator
CLH39_RS00615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_RS00635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_RS00640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS00665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS00680	COG1187	pseudouridine synthase activity
CLH39_RS00690	COG0592	DNA-directed DNA polymerase activity
CLH39_RS00695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLH39_RS00700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLH39_RS00705	COG0594	ribonuclease P activity
CLH39_RS00710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLH39_RS00715	COG0706	membrane insertase activity
CLH39_RS00720	COG0753	catalase activity
CLH39_RS00745	COG1335	isochorismatase
CLH39_RS00750	COG2309	aminopeptidase activity
CLH39_RS00755	COG0596	Alpha beta hydrolase
CLH39_RS00775	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS00810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLH39_RS00865	COG3645	SOS response
CLH39_RS00905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLH39_RS00915	COG0688	phosphatidylethanolamine metabolic process
CLH39_RS00920	COG3706	GGDEF domain
CLH39_RS00925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_RS00935	COG0436	Aminotransferase
CLH39_RS00940	COG0445	tRNA wobble uridine modification
CLH39_RS00945	COG0357	Ribosomal RNA small subunit methyltransferase G
CLH39_RS00950	COG1192	Involved in chromosome partitioning
CLH39_RS00955	COG1475	DNA binding
CLH39_RS00980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLH39_RS01005	COG0081	regulation of translation
CLH39_RS01010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLH39_RS01015	COG0222	ribosome binding
CLH39_RS01020	COG0085	RNA polymerase activity
CLH39_RS01025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLH39_RS01030	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CLH39_RS01060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLH39_RS01065	COG0049	tRNA binding
CLH39_RS01070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLH39_RS01075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLH39_RS01080	COG0051	transcription antitermination factor activity, RNA binding
CLH39_RS01085	COG4176	ABC-type proline glycine betaine transport system permease component
CLH39_RS01090	COG4175	Glycine betaine
CLH39_RS01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLH39_RS01100	COG0088	Forms part of the polypeptide exit tunnel
CLH39_RS01105	COG0089	rRNA binding
CLH39_RS01110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLH39_RS01115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLH39_RS01120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLH39_RS01125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLH39_RS01130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLH39_RS01135	COG0255	Belongs to the universal ribosomal protein uL29 family
CLH39_RS01140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLH39_RS01155	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS01160	COG1116	anion transmembrane transporter activity
CLH39_RS01175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_RS01175	COG1648	precorrin-2 dehydrogenase activity
CLH39_RS01180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLH39_RS01185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLH39_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_RS01205	COG2067	long-chain fatty acid transport protein
CLH39_RS01215	COG0183	Belongs to the thiolase family
CLH39_RS01220	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS01235	COG1538	Outer membrane efflux protein
CLH39_RS01275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLH39_RS01280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLH39_RS01285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLH39_RS01290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLH39_RS01295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLH39_RS01300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLH39_RS01305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLH39_RS01310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLH39_RS01315	COG1841	ribosomal large subunit assembly
CLH39_RS01320	COG0200	Binds to the 23S rRNA
CLH39_RS01325	COG0201	protein transport
CLH39_RS01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLH39_RS01340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLH39_RS01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLH39_RS01350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLH39_RS01355	COG0202	RNA polymerase activity
CLH39_RS01360	COG0203	ribosomal protein L17
CLH39_RS01365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_RS01385	COG4232	protein-disulfide reductase activity
CLH39_RS01390	COG0113	porphobilinogen synthase activity
CLH39_RS01395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLH39_RS01405	COG1333	cytochrome c biogenesis protein
CLH39_RS01410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLH39_RS01415	COG5001	Diguanylate cyclase
CLH39_RS01415	COG5002	protein histidine kinase activity
CLH39_RS01435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLH39_RS01440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLH39_RS01445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLH39_RS01455	COG2814	Major facilitator Superfamily
CLH39_RS01470	COG3712	iron ion homeostasis
CLH39_RS01475	COG1595	DNA-templated transcription, initiation
CLH39_RS01480	COG1802	Transcriptional regulator
CLH39_RS01485	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_RS01490	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS01495	COG0251	oxidation-reduction process
CLH39_RS01500	COG2814	Major facilitator Superfamily
CLH39_RS01520	COG2814	Major facilitator Superfamily
CLH39_RS01525	COG1309	transcriptional regulator
CLH39_RS01530	COG1802	Transcriptional regulator
CLH39_RS01540	COG3069	C4-dicarboxylate transmembrane transporter activity
CLH39_RS01590	COG2423	ornithine cyclodeaminase activity
CLH39_RS01610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLH39_RS01615	COG2365	Tyrosine phosphatase family
CLH39_RS01645	COG0625	glutathione transferase activity
CLH39_RS01675	COG0789	Transcriptional regulator
CLH39_RS01685	COG0583	DNA-binding transcription factor activity
CLH39_RS01710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLH39_RS01715	COG2986	histidine ammonia-lyase
CLH39_RS01735	COG1228	amidohydrolase
CLH39_RS01745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS01770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLH39_RS01775	COG3568	Endonuclease Exonuclease Phosphatase
CLH39_RS01795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLH39_RS01815	COG0109	protoheme IX farnesyltransferase activity
CLH39_RS01850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLH39_RS01870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLH39_RS01880	COG1522	sequence-specific DNA binding
CLH39_RS01895	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS01930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLH39_RS01955	COG1595	DNA-templated transcription, initiation
CLH39_RS01995	COG0583	DNA-binding transcription factor activity
CLH39_RS02000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_RS02005	COG3284	Transcriptional regulator
CLH39_RS02015	COG2823	Periplasmic or secreted lipoprotein
CLH39_RS02035	COG1335	isochorismatase
CLH39_RS02040	COG1335	isochorismatase
CLH39_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS02055	COG0477	Major facilitator Superfamily
CLH39_RS02060	COG0583	DNA-binding transcription factor activity
CLH39_RS02065	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CLH39_RS02080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_RS02090	COG2226	methyltransferase
CLH39_RS02095	COG3706	GGDEF domain
CLH39_RS02100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLH39_RS02110	COG0656	L-ascorbic acid biosynthetic process
CLH39_RS02115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLH39_RS02135	COG3483	tryptophan 2,3-dioxygenase activity
CLH39_RS02145	COG1522	sequence-specific DNA binding
CLH39_RS02150	COG1802	Transcriptional regulator
CLH39_RS02155	COG0129	dihydroxy-acid dehydratase activity
CLH39_RS02160	COG2084	Dehydrogenase
CLH39_RS02170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_RS02175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS02195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_RS02210	COG4150	thiosulfate binding
CLH39_RS02215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_RS02220	COG4208	sulfate ABC transporter
CLH39_RS02230	COG2969	positive regulation of protein catabolic process
CLH39_RS02235	COG0625	glutathione transferase activity
CLH39_RS02240	COG2857	Cytochrome c1
CLH39_RS02245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLH39_RS02250	COG0723	plastoquinol--plastocyanin reductase activity
CLH39_RS02255	COG1970	mechanosensitive ion channel activity
CLH39_RS02265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLH39_RS02275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLH39_RS02280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLH39_RS02285	COG0537	adenosine 5'-monophosphoramidase activity
CLH39_RS02290	COG0140	phosphoribosyl-ATP diphosphatase activity
CLH39_RS02300	COG0107	imidazoleglycerol-phosphate synthase activity
CLH39_RS02305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLH39_RS02315	COG0131	Imidazoleglycerol-phosphate dehydratase
CLH39_RS02320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLH39_RS02330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLH39_RS02340	COG0842	Transport permease protein
CLH39_RS02345	COG1131	(ABC) transporter
CLH39_RS02360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLH39_RS02365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLH39_RS02370	COG1127	ABC transporter
CLH39_RS02385	COG1024	Enoyl-CoA hydratase
CLH39_RS02385	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_RS02390	COG0183	Belongs to the thiolase family
CLH39_RS02485	COG2885	chlorophyll binding
CLH39_RS02505	COG0697	spore germination
CLH39_RS02510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS02515	COG0697	spore germination
CLH39_RS02520	COG2233	PERMEase
CLH39_RS02525	COG3321	synthase
CLH39_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS02525	COG0604	alcohol dehydrogenase
CLH39_RS02530	COG0156	8-amino-7-oxononanoate synthase activity
CLH39_RS02565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLH39_RS02570	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS02600	COG1215	transferase activity, transferring glycosyl groups
CLH39_RS02625	COG0166	Belongs to the GPI family
CLH39_RS02640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CLH39_RS02655	COG4263	nitrous-oxide reductase activity
CLH39_RS02665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLH39_RS02670	COG0709	Synthesizes selenophosphate from selenide and ATP
CLH39_RS02695	COG3276	selenocysteine insertion sequence binding
CLH39_RS02700	COG1921	L-seryl-tRNASec selenium transferase activity
CLH39_RS02710	COG2864	formate dehydrogenase
CLH39_RS02715	COG0437	4 iron, 4 sulfur cluster binding
CLH39_RS02745	COG1116	anion transmembrane transporter activity
CLH39_RS02765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_RS02770	COG0477	Major facilitator Superfamily
CLH39_RS02785	COG5002	protein histidine kinase activity
CLH39_RS02805	COG3180	Ammonia monooxygenase
CLH39_RS02830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_RS02840	COG1595	DNA-templated transcription, initiation
CLH39_RS02855	COG2264	protein methyltransferase activity
CLH39_RS02860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLH39_RS02875	COG0811	peptide transport
CLH39_RS02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_RS02950	COG3550	peptidyl-serine autophosphorylation
CLH39_RS02970	COG2890	protein-(glutamine-N5) methyltransferase activity
CLH39_RS02975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLH39_RS02980	COG0163	prenyltransferase activity
CLH39_RS02985	COG0037	tRNA processing
CLH39_RS03000	COG1024	Enoyl-CoA hydratase
CLH39_RS03010	COG0356	it plays a direct role in the translocation of protons across the membrane
CLH39_RS03025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLH39_RS03030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLH39_RS03035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLH39_RS03045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLH39_RS03060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_RS03075	COG3473	Maleate cis-trans isomerase
CLH39_RS03080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLH39_RS03095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLH39_RS03115	COG2204	response regulator
CLH39_RS03125	COG2205	protein histidine kinase activity
CLH39_RS03130	COG0745	RESPONSE REGULATOR receiver
CLH39_RS03135	COG4771	TonB-dependent receptor
CLH39_RS03140	COG2226	methyltransferase
CLH39_RS03145	COG1040	competence protein
CLH39_RS03150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLH39_RS03155	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS03160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLH39_RS03165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CLH39_RS03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLH39_RS03180	COG0588	phosphoglycerate mutase activity
CLH39_RS03190	COG0793	Belongs to the peptidase S41A family
CLH39_RS03195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLH39_RS03215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLH39_RS03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLH39_RS03235	COG0792	nuclease activity
CLH39_RS03240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLH39_RS03245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLH39_RS03250	COG1660	Displays ATPase and GTPase activities
CLH39_RS03255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLH39_RS03260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLH39_RS03270	COG1137	ATPase activity
CLH39_RS03285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLH39_RS03300	COG1271	oxidase subunit
CLH39_RS03305	COG1294	oxidase, subunit
CLH39_RS03315	COG4988	ABC transporter
CLH39_RS03320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLH39_RS03360	COG1238	metal cluster binding
CLH39_RS03365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLH39_RS03370	COG1984	allophanate hydrolase subunit 2
CLH39_RS03375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLH39_RS03390	COG0745	RESPONSE REGULATOR receiver
CLH39_RS03395	COG2226	methyltransferase
CLH39_RS03410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLH39_RS03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLH39_RS03425	COG1538	Outer membrane efflux protein
CLH39_RS03430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLH39_RS03435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLH39_RS03440	COG0351	phosphomethylpyrimidine kinase
CLH39_RS03445	COG2022	thiamine diphosphate biosynthetic process
CLH39_RS03460	COG0598	Magnesium transport protein CorA
CLH39_RS03480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS03495	COG1595	DNA-templated transcription, initiation
CLH39_RS03510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLH39_RS03515	COG4206	TonB-dependent receptor
CLH39_RS03530	COG0477	Major facilitator Superfamily
CLH39_RS03540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLH39_RS03545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLH39_RS03560	COG0237	dephospho-CoA kinase activity
CLH39_RS03565	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CLH39_RS03590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLH39_RS03595	COG0494	nUDIX hydrolase
CLH39_RS03605	COG0142	geranyltranstransferase activity
CLH39_RS03610	COG0786	glutamate:sodium symporter activity
CLH39_RS03625	COG3604	Transcriptional regulator
CLH39_RS03650	COG3384	dioxygenase
CLH39_RS03655	COG2259	Doxx family
CLH39_RS03660	COG0583	DNA-binding transcription factor activity
CLH39_RS03665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLH39_RS03670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLH39_RS03675	COG0154	amidase activity
CLH39_RS03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLH39_RS03685	COG1077	Cell shape determining protein MreB Mrl
CLH39_RS03690	COG1792	Involved in formation and maintenance of cell shape
CLH39_RS03700	COG0768	penicillin binding
CLH39_RS03705	COG0772	Belongs to the SEDS family
CLH39_RS03715	COG2177	Part of the ABC transporter FtsEX involved in
CLH39_RS03720	COG2884	Cell division ATP-binding protein ftsE
CLH39_RS03725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS03730	COG4597	amino acid ABC transporter
CLH39_RS03735	COG0765	amino acid transport
CLH39_RS03740	COG1126	abc transporter atp-binding protein
CLH39_RS03755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLH39_RS03780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLH39_RS03785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLH39_RS03790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLH39_RS03795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLH39_RS03800	COG3237	CsbD-like
CLH39_RS03810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLH39_RS03825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLH39_RS03830	COG0352	thiamine-phosphate diphosphorylase activity
CLH39_RS03845	COG1678	Uncharacterized ACR, COG1678
CLH39_RS03860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_RS03870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLH39_RS03875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLH39_RS03890	COG3150	esterase
CLH39_RS03895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLH39_RS03905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLH39_RS03910	COG0511	ligase activity, forming carbon-carbon bonds
CLH39_RS03915	COG0439	Biotin carboxylase
CLH39_RS03930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLH39_RS03935	COG3133	Outer membrane lipoprotein
CLH39_RS03940	COG2169	Transcriptional regulator
CLH39_RS03940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_RS03950	COG0762	integral membrane protein
CLH39_RS03980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLH39_RS03985	COG4566	intracellular signal transduction
CLH39_RS03990	COG0745	RESPONSE REGULATOR receiver
CLH39_RS03990	COG4191	Histidine kinase
CLH39_RS03990	COG2205	protein histidine kinase activity
CLH39_RS04020	COG3028	Belongs to the UPF0307 family
CLH39_RS04025	COG0312	modulator of DNA gyrase
CLH39_RS04030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS04035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLH39_RS04040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLH39_RS04045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLH39_RS04055	COG0316	Belongs to the HesB IscA family
CLH39_RS04060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CLH39_RS04065	COG0739	heme binding
CLH39_RS04070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLH39_RS04075	COG1881	PFAM PEBP family protein
CLH39_RS04080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_RS04085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLH39_RS04090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLH39_RS04090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLH39_RS04130	COG0642	Histidine kinase
CLH39_RS04135	COG0745	RESPONSE REGULATOR receiver
CLH39_RS04140	COG0431	NADPH-dependent FMN reductase
CLH39_RS04145	COG1393	Belongs to the ArsC family
CLH39_RS04160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS04170	COG1280	lysine exporter protein (LysE YggA)
CLH39_RS04195	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CLH39_RS04215	COG1024	Enoyl-CoA hydratase
CLH39_RS04225	COG0604	alcohol dehydrogenase
CLH39_RS04260	COG1877	trehalose-phosphatase activity
CLH39_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS04280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CLH39_RS04305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLH39_RS04330	COG1054	Belongs to the UPF0176 family
CLH39_RS04340	COG1301	dicarboxylic acid transport
CLH39_RS04345	COG4191	Histidine kinase
CLH39_RS04350	COG2204	response regulator
CLH39_RS04375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLH39_RS04395	COG0741	lytic transglycosylase activity
CLH39_RS04395	COG1388	LysM domain
CLH39_RS04400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLH39_RS04405	COG2226	methyltransferase
CLH39_RS04410	COG0328	RNA-DNA hybrid ribonuclease activity
CLH39_RS04415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_RS04420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_RS04435	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS04440	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_RS04445	COG0583	DNA-binding transcription factor activity
CLH39_RS04450	COG2031	fatty acid transporter
CLH39_RS04455	COG4206	TonB-dependent receptor
CLH39_RS04465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_RS04470	COG1120	ATPase activity
CLH39_RS04485	COG0596	Alpha beta hydrolase
CLH39_RS04490	COG2309	aminopeptidase activity
CLH39_RS04495	COG1335	isochorismatase
CLH39_RS04520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS04545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_RS04550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_RS04560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS04565	COG3608	succinylglutamate desuccinylase aspartoacylase
CLH39_RS04565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLH39_RS04570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLH39_RS04570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLH39_RS04580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLH39_RS04590	COG2188	Transcriptional regulator
CLH39_RS04595	COG1234	tRNA 3'-trailer cleavage
CLH39_RS04610	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS04625	COG3706	GGDEF domain
CLH39_RS04650	COG0411	ABC transporter
CLH39_RS04655	COG0410	ABC transporter
CLH39_RS04665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_RS04665	COG2010	Cytochrome c
CLH39_RS04670	COG2080	2 iron, 2 sulfur cluster binding
CLH39_RS04675	COG2010	Cytochrome c
CLH39_RS04675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_RS04680	COG0596	Alpha beta hydrolase
CLH39_RS04685	COG2309	aminopeptidase activity
CLH39_RS04690	COG1335	isochorismatase
CLH39_RS04715	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CLH39_RS04745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLH39_RS04750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLH39_RS04755	COG0742	ribosomal rna small subunit methyltransferase
CLH39_RS04780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLH39_RS04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLH39_RS04790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLH39_RS04795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLH39_RS04805	COG1414	Transcriptional regulator
CLH39_RS04820	COG0284	orotidine-5'-phosphate decarboxylase activity
CLH39_RS04825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLH39_RS04835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLH39_RS04850	COG0154	amidase activity
CLH39_RS04855	COG3706	GGDEF domain
CLH39_RS04865	COG1741	Belongs to the pirin family
CLH39_RS04870	COG0583	DNA-binding transcription factor activity
CLH39_RS04885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLH39_RS04890	COG2895	sulfate adenylyltransferase (ATP) activity
CLH39_RS04900	COG0697	spore germination
CLH39_RS04915	COG3634	alkyl hydroperoxide reductase activity
CLH39_RS04920	COG0583	DNA-binding transcription factor activity
CLH39_RS04925	COG0427	acetyl-CoA hydrolase
CLH39_RS04945	COG3845	ABC transporter
CLH39_RS04950	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS04955	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS04980	COG0596	Alpha beta hydrolase
CLH39_RS04995	COG0823	Involved in the tonB-independent uptake of proteins
CLH39_RS05010	COG0811	peptide transport
CLH39_RS05015	COG0824	Thioesterase
CLH39_RS05020	COG0442	prolyl-tRNA aminoacylation
CLH39_RS05025	COG0494	nUDIX hydrolase
CLH39_RS05040	COG2084	Dehydrogenase
CLH39_RS05045	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_RS05050	COG3842	ATPase activity
CLH39_RS05055	COG1177	transmembrane transport
CLH39_RS05095	COG4654	Cytochrome c, class I
CLH39_RS05100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLH39_RS05170	COG0415	Belongs to the DNA photolyase family
CLH39_RS05180	COG0418	dihydroorotase activity
CLH39_RS05190	COG2255	four-way junction helicase activity
CLH39_RS05200	COG0632	four-way junction helicase activity
CLH39_RS05205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLH39_RS05215	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CLH39_RS05225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_RS05250	COG0429	hydrolase of the alpha beta-hydrolase fold
CLH39_RS05270	COG0513	Belongs to the DEAD box helicase family
CLH39_RS05290	COG1414	Transcriptional regulator
CLH39_RS05310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CLH39_RS05315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLH39_RS05330	COG1846	Transcriptional regulator
CLH39_RS05335	COG1027	Aspartate ammonia-lyase
CLH39_RS05350	COG0517	IMP dehydrogenase activity
CLH39_RS05350	COG0516	GMP reductase activity
CLH39_RS05415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLH39_RS05465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLH39_RS05485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS05490	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_RS05505	COG0697	spore germination
CLH39_RS05535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_RS05545	COG0789	Transcriptional regulator
CLH39_RS05555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLH39_RS05560	COG0505	Belongs to the CarA family
CLH39_RS05575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_RS05590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLH39_RS05600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLH39_RS05605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLH39_RS05615	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLH39_RS05620	COG1538	Outer membrane efflux protein
CLH39_RS05625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_RS05630	COG0842	Transport permease protein
CLH39_RS05630	COG1129	ABC transporter
CLH39_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS05680	COG2814	Major facilitator Superfamily
CLH39_RS05685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS05690	COG0154	amidase activity
CLH39_RS05710	COG2197	response regulator
CLH39_RS05715	COG0784	Response regulator, receiver
CLH39_RS05715	COG2205	protein histidine kinase activity
CLH39_RS05720	COG0784	Response regulator, receiver
CLH39_RS05720	COG2205	protein histidine kinase activity
CLH39_RS05730	COG3121	Chaperone
CLH39_RS05750	COG2814	Major facilitator Superfamily
CLH39_RS05760	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CLH39_RS05765	COG3971	2-oxopent-4-enoate hydratase activity
CLH39_RS05780	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_RS05795	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CLH39_RS05800	COG4638	Rieske (2fe-2S)
CLH39_RS05805	COG0583	DNA-binding transcription factor activity
CLH39_RS05815	COG0513	Belongs to the DEAD box helicase family
CLH39_RS05820	COG1414	Transcriptional regulator
CLH39_RS05855	COG1454	alcohol dehydrogenase
CLH39_RS05870	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLH39_RS05875	COG2819	hydrolase of the alpha beta superfamily
CLH39_RS05880	COG3058	Necessary for formate dehydrogenase activity
CLH39_RS05885	COG2864	formate dehydrogenase
CLH39_RS05890	COG0437	4 iron, 4 sulfur cluster binding
CLH39_RS05895	COG0243	molybdopterin cofactor binding
CLH39_RS05895	COG3383	formate dehydrogenase (NAD+) activity
CLH39_RS05905	COG2814	Major facilitator Superfamily
CLH39_RS05925	COG2814	Major facilitator Superfamily
CLH39_RS05950	COG1538	Outer membrane efflux protein
CLH39_RS05975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLH39_RS05985	COG1301	dicarboxylic acid transport
CLH39_RS05990	COG0477	Major facilitator Superfamily
CLH39_RS06000	COG2267	carboxylic ester hydrolase activity
CLH39_RS06015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLH39_RS06020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_RS06025	COG0735	belongs to the Fur family
CLH39_RS06030	COG0497	DNA recombination
CLH39_RS06040	COG1420	regulation of RNA biosynthetic process
CLH39_RS06045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLH39_RS06050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLH39_RS06055	COG0443	Heat shock 70 kDa protein
CLH39_RS06060	COG0484	heat shock protein binding
CLH39_RS06065	COG0612	Peptidase, M16
CLH39_RS06125	COG4964	Belongs to the GSP D family
CLH39_RS06165	COG2204	response regulator
CLH39_RS06185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLH39_RS06210	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS06215	COG2272	Belongs to the type-B carboxylesterase lipase family
CLH39_RS06235	COG0477	Major facilitator Superfamily
CLH39_RS06255	COG0492	ferredoxin-NADP+ reductase activity
CLH39_RS06260	COG1674	ftsk spoiiie
CLH39_RS06265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLH39_RS06270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLH39_RS06275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLH39_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS06300	COG3022	response to hydroperoxide
CLH39_RS06305	COG1289	transmembrane transporter activity
CLH39_RS06310	COG0028	Belongs to the TPP enzyme family
CLH39_RS06315	COG0440	acetolactate synthase activity
CLH39_RS06320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLH39_RS06325	COG1183	phosphatidylcholine synthase activity
CLH39_RS06330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLH39_RS06335	COG1185	polyribonucleotide nucleotidyltransferase activity
CLH39_RS06355	COG0604	alcohol dehydrogenase
CLH39_RS06360	COG0149	triose-phosphate isomerase activity
CLH39_RS06375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS06380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_RS06385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_RS06390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_RS06395	COG0649	NAD binding
CLH39_RS06410	COG1034	ATP synthesis coupled electron transport
CLH39_RS06415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLH39_RS06420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLH39_RS06430	COG0713	ATP synthesis coupled electron transport
CLH39_RS06445	COG1007	ATP synthesis coupled electron transport
CLH39_RS06455	COG2070	2-Nitropropane dioxygenase
CLH39_RS06460	COG0560	Phosphoserine phosphatase
CLH39_RS06465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLH39_RS06470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLH39_RS06475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLH39_RS06490	COG1214	PFAM Peptidase M22, glycoprotease
CLH39_RS06495	COG1573	uracil-dna glycosylase
CLH39_RS06505	COG1196	nuclear chromosome segregation
CLH39_RS06515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLH39_RS06520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_RS06530	COG2917	probably involved in intracellular septation
CLH39_RS06535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLH39_RS06560	COG3047	cAMP biosynthetic process
CLH39_RS06565	COG1129	ABC transporter
CLH39_RS06570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLH39_RS06575	COG2878	Part of a membrane complex involved in electron transport
CLH39_RS06585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLH39_RS06590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLH39_RS06600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLH39_RS06605	COG0133	tryptophan synthase activity
CLH39_RS06610	COG0159	tryptophan synthase activity
CLH39_RS06615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLH39_RS06620	COG1530	ribonuclease E activity
CLH39_RS06625	COG0564	pseudouridine synthase activity
CLH39_RS06630	COG0546	phosphoglycolate phosphatase activity
CLH39_RS06635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLH39_RS06640	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CLH39_RS06645	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLH39_RS06655	COG0424	maF-like protein
CLH39_RS06660	COG1399	metal-binding, possibly nucleic acid-binding protein
CLH39_RS06665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLH39_RS06675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLH39_RS06680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLH39_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS06690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLH39_RS06695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLH39_RS06720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLH39_RS06735	COG0571	ribonuclease III activity
CLH39_RS06740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLH39_RS06745	COG1381	Involved in DNA repair and RecF pathway recombination
CLH39_RS06760	COG1045	serine acetyltransferase
CLH39_RS06775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLH39_RS06785	COG0583	DNA-binding transcription factor activity
CLH39_RS06795	COG0583	DNA-binding transcription factor activity
CLH39_RS06805	COG0791	NLP P60 protein
CLH39_RS06815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLH39_RS06850	COG0504	CTP synthase activity
CLH39_RS06860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLH39_RS06875	COG2814	Major facilitator Superfamily
CLH39_RS06885	COG0148	phosphopyruvate hydratase activity
CLH39_RS06890	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLH39_RS06900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLH39_RS06915	COG1981	membrane
CLH39_RS06920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLH39_RS06925	COG1466	dna polymerase III delta subunit
CLH39_RS06935	COG0495	leucyl-tRNA aminoacylation
CLH39_RS06940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLH39_RS06945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLH39_RS06950	COG2814	Major facilitator Superfamily
CLH39_RS06955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLH39_RS06965	COG4176	ABC-type proline glycine betaine transport system permease component
CLH39_RS06970	COG4175	Glycine betaine
CLH39_RS06975	COG0534	Mate efflux family protein
CLH39_RS06990	COG2271	Major facilitator Superfamily
CLH39_RS07000	COG0477	Major facilitator Superfamily
CLH39_RS07005	COG1737	Transcriptional regulator
CLH39_RS07010	COG2003	Belongs to the UPF0758 family
CLH39_RS07015	COG1047	Peptidyl-prolyl cis-trans
CLH39_RS07020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLH39_RS07025	COG0625	glutathione transferase activity
CLH39_RS07030	COG2084	Dehydrogenase
CLH39_RS07040	COG0023	Translation Initiation Factor
CLH39_RS07060	COG0424	maF-like protein
CLH39_RS07065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLH39_RS07070	COG0799	negative regulation of ribosome biogenesis
CLH39_RS07075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLH39_RS07085	COG0151	Belongs to the GarS family
CLH39_RS07090	COG0217	transcriptional regulatory protein
CLH39_RS07095	COG0433	COG0433 Predicted ATPase
CLH39_RS07105	COG0473	3-isopropylmalate dehydrogenase activity
CLH39_RS07120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLH39_RS07125	COG0308	aminopeptidase N
CLH39_RS07140	COG0312	modulator of DNA gyrase
CLH39_RS07150	COG1846	Transcriptional regulator
CLH39_RS07155	COG0456	acetyltransferase
CLH39_RS07165	COG0662	Cupin 2, conserved barrel domain protein
CLH39_RS07170	COG5285	phytanoyl-CoA dioxygenase
CLH39_RS07185	COG1126	abc transporter atp-binding protein
CLH39_RS07190	COG0765	amino acid transport
CLH39_RS07195	COG0765	amino acid transport
CLH39_RS07200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS07205	COG1966	Carbon starvation protein
CLH39_RS07210	COG2879	small protein
CLH39_RS07215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLH39_RS07220	COG0277	FAD linked oxidase domain protein
CLH39_RS07225	COG0482	sulfurtransferase activity
CLH39_RS07230	COG0730	response to heat
CLH39_RS07235	COG0657	acetylesterase activity
CLH39_RS07245	COG0625	glutathione transferase activity
CLH39_RS07255	COG3909	cytochrome
CLH39_RS07260	COG0004	ammonium transporteR
CLH39_RS07265	COG0347	Belongs to the P(II) protein family
CLH39_RS07270	COG1846	Transcriptional regulator
CLH39_RS07275	COG2175	clavaminate synthase activity
CLH39_RS07280	COG2271	Major facilitator Superfamily
CLH39_RS07295	COG2321	neutral zinc metallopeptidase
CLH39_RS07300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLH39_RS07315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLH39_RS07320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLH39_RS07335	COG2119	membrane
CLH39_RS07340	COG0840	transmembrane signaling receptor activity
CLH39_RS07355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLH39_RS07360	COG2046	Belongs to the sulfate adenylyltransferase family
CLH39_RS07370	COG0784	Response regulator, receiver
CLH39_RS07370	COG2198	Histidine kinase
CLH39_RS07370	COG2205	protein histidine kinase activity
CLH39_RS07380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_RS07400	COG1280	lysine exporter protein (LysE YggA)
CLH39_RS07405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLH39_RS07415	COG0625	glutathione transferase activity
CLH39_RS07465	COG0488	(ABC) transporter
CLH39_RS07475	COG1309	transcriptional regulator
CLH39_RS07480	COG0251	oxidation-reduction process
CLH39_RS07490	COG0436	Aminotransferase
CLH39_RS07500	COG4335	DNA alkylation repair
CLH39_RS07505	COG1408	metallophosphoesterase
CLH39_RS07510	COG0753	catalase activity
CLH39_RS07525	COG4771	TonB-dependent receptor
CLH39_RS07535	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLH39_RS07545	COG0583	DNA-binding transcription factor activity
CLH39_RS07555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLH39_RS07570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLH39_RS07580	COG0287	Prephenate dehydrogenase
CLH39_RS07585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLH39_RS07590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLH39_RS07610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CLH39_RS07615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLH39_RS07620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_RS07635	COG2951	lytic endotransglycosylase activity
CLH39_RS07640	COG0123	including yeast histone deacetylase and acetoin utilization protein
CLH39_RS07655	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS07660	COG0450	alkyl hydroperoxide reductase
CLH39_RS07680	COG0335	large ribosomal subunit rRNA binding
CLH39_RS07690	COG1162	GTPase activity
CLH39_RS07695	COG0501	Belongs to the peptidase M48B family
CLH39_RS07700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CLH39_RS07705	COG3396	Phenylacetate-CoA oxygenase
CLH39_RS07710	COG3460	Phenylacetate-CoA oxygenase
CLH39_RS07715	COG3396	Phenylacetate-CoA oxygenase
CLH39_RS07720	COG2151	metal-sulfur cluster biosynthetic enzyme
CLH39_RS07725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLH39_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_RS07735	COG1024	Enoyl-CoA hydratase
CLH39_RS07740	COG2050	protein possibly involved in aromatic compounds catabolism
CLH39_RS07750	COG0736	holo-[acyl-carrier-protein] synthase activity
CLH39_RS07755	COG1472	Belongs to the glycosyl hydrolase 3 family
CLH39_RS07775	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLH39_RS07775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLH39_RS07780	COG2224	Isocitrate lyase
CLH39_RS07785	COG2217	Heavy metal translocating P-type atpase
CLH39_RS07795	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_RS07815	COG0348	domain, Protein
CLH39_RS07830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLH39_RS07835	COG0542	response to heat
CLH39_RS07840	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLH39_RS07845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CLH39_RS07875	COG0601	transmembrane transport
CLH39_RS07880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_RS07890	COG4638	Rieske (2fe-2S)
CLH39_RS07905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLH39_RS07910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLH39_RS07935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_RS07970	COG2351	hydroxyisourate hydrolase activity
CLH39_RS07985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLH39_RS07990	COG0425	Belongs to the sulfur carrier protein TusA family
CLH39_RS07995	COG0228	four-way junction DNA binding
CLH39_RS08005	COG0336	Belongs to the RNA methyltransferase TrmD family
CLH39_RS08010	COG0697	spore germination
CLH39_RS08015	COG0583	DNA-binding transcription factor activity
CLH39_RS08020	COG0525	valine-tRNA ligase activity
CLH39_RS08025	COG0105	UTP biosynthetic process
CLH39_RS08030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLH39_RS08045	COG0124	histidyl-tRNA synthetase
CLH39_RS08050	COG2976	Protein conserved in bacteria
CLH39_RS08055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_RS08060	COG1160	GTP binding
CLH39_RS08070	COG1923	regulation of RNA biosynthetic process
CLH39_RS08075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLH39_RS08080	COG0330	HflC and HflK could
CLH39_RS08085	COG0330	HflC and HflK could
CLH39_RS08095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLH39_RS08100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CLH39_RS08105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLH39_RS08120	COG2205	protein histidine kinase activity
CLH39_RS08125	COG0745	RESPONSE REGULATOR receiver
CLH39_RS08135	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_RS08145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLH39_RS08170	COG3135	benzoate transporter
CLH39_RS08175	COG2207	Transcriptional regulator
CLH39_RS08180	COG2807	transmembrane transport
CLH39_RS08185	COG2814	Major facilitator Superfamily
CLH39_RS08190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_RS08200	COG1741	Belongs to the pirin family
CLH39_RS08210	COG0625	glutathione transferase activity
CLH39_RS08215	COG3530	Putative quorum-sensing-regulated virulence factor
CLH39_RS08220	COG0412	Dienelactone hydrolase
CLH39_RS08240	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_RS08245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_RS08255	COG3842	ATPase activity
CLH39_RS08260	COG0583	DNA-binding transcription factor activity
CLH39_RS08290	COG2375	cellular response to nickel ion
CLH39_RS08310	COG1850	ribulose-bisphosphate carboxylase activity
CLH39_RS08325	COG1126	abc transporter atp-binding protein
CLH39_RS08330	COG0765	amino acid transport
CLH39_RS08335	COG0765	amino acid transport
CLH39_RS08370	COG0557	exoribonuclease II activity
CLH39_RS08375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLH39_RS08380	COG0626	cystathionine gamma-synthase activity
CLH39_RS08385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLH39_RS08390	COG2010	Cytochrome c
CLH39_RS08400	COG1648	precorrin-2 dehydrogenase activity
CLH39_RS08400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_RS08405	COG0535	radical SAM domain protein
CLH39_RS08420	COG1522	sequence-specific DNA binding
CLH39_RS08435	COG1648	precorrin-2 dehydrogenase activity
CLH39_RS08435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLH39_RS08570	COG4626	Terminase
CLH39_RS08570	COG1802	Transcriptional regulator
CLH39_RS08620	COG0740	serine-type endopeptidase activity
CLH39_RS08715	COG2135	peptidase activity
CLH39_RS08740	COG1278	Cold shock
CLH39_RS08760	COG4106	trans-aconitate 2-methyltransferase activity
CLH39_RS08765	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLH39_RS08770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_RS08775	COG4208	sulfate ABC transporter
CLH39_RS08780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_RS08805	COG0642	Histidine kinase
CLH39_RS08810	COG3158	transport of potassium into the cell
CLH39_RS08825	COG2212	antiporter activity
CLH39_RS08835	COG0651	ATP synthesis coupled electron transport
CLH39_RS08840	COG1006	Multisubunit Na H antiporter MnhC subunit
CLH39_RS08845	COG2111	Na H antiporter
CLH39_RS08845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLH39_RS08850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLH39_RS08855	COG2070	2-Nitropropane dioxygenase
CLH39_RS08870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLH39_RS08885	COG0540	Belongs to the ATCase OTCase family
CLH39_RS08900	COG3162	membrane
CLH39_RS08905	COG1024	Enoyl-CoA hydratase
CLH39_RS08910	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_RS08925	COG0477	Major facilitator Superfamily
CLH39_RS08940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLH39_RS08945	COG2137	regulation of response to DNA damage stimulus
CLH39_RS08950	COG0583	DNA-binding transcription factor activity
CLH39_RS08955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLH39_RS08965	COG0045	succinate-CoA ligase (ADP-forming) activity
CLH39_RS08970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLH39_RS08975	COG0861	Integral membrane protein TerC family
CLH39_RS08980	COG0181	hydroxymethylbilane synthase activity
CLH39_RS08990	COG2959	enzyme of heme biosynthesis
CLH39_RS09015	COG3712	iron ion homeostasis
CLH39_RS09020	COG4774	siderophore transport
CLH39_RS09030	COG1595	DNA-templated transcription, initiation
CLH39_RS09070	COG4964	Belongs to the GSP D family
CLH39_RS09115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_RS09120	COG1136	(ABC) transporter
CLH39_RS09120	COG0577	efflux transmembrane transporter activity
CLH39_RS09125	COG1538	Outer membrane efflux protein
CLH39_RS09135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLH39_RS09145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLH39_RS09155	COG1295	ribonuclease BN
CLH39_RS09165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLH39_RS09170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLH39_RS09185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_RS09190	COG0625	glutathione transferase activity
CLH39_RS09195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLH39_RS09215	COG0473	3-isopropylmalate dehydrogenase activity
CLH39_RS09220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLH39_RS09230	COG0101	tRNA pseudouridine synthase activity
CLH39_RS09240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS09245	COG0135	phosphoribosylanthranilate isomerase activity
CLH39_RS09250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_RS09265	COG2207	Transcriptional regulator
CLH39_RS09270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLH39_RS09270	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_RS09275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLH39_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_RS09285	COG1666	GTP binding
CLH39_RS09295	COG0842	Transport permease protein
CLH39_RS09300	COG1131	(ABC) transporter
CLH39_RS09305	COG0590	tRNA wobble adenosine to inosine editing
CLH39_RS09310	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLH39_RS09315	COG0488	(ABC) transporter
CLH39_RS09335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_RS09340	COG2252	PERMEase
CLH39_RS09345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLH39_RS09350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLH39_RS09355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLH39_RS09360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLH39_RS09370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLH39_RS09380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_RS09395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CLH39_RS09400	COG0789	Transcriptional regulator
CLH39_RS09405	COG0165	Argininosuccinate lyase
CLH39_RS09410	COG0668	transmembrane transport
CLH39_RS09420	COG0656	L-ascorbic acid biosynthetic process
CLH39_RS09425	COG2814	Major facilitator Superfamily
CLH39_RS09430	COG3161	chorismate lyase activity
CLH39_RS09435	COG1187	pseudouridine synthase activity
CLH39_RS09440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CLH39_RS09445	COG0584	glycerophosphoryl diester phosphodiesterase
CLH39_RS09450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_RS09455	COG0739	heme binding
CLH39_RS09460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLH39_RS09480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_RS09485	COG0583	DNA-binding transcription factor activity
CLH39_RS09490	COG0583	DNA-binding transcription factor activity
CLH39_RS09495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLH39_RS09500	COG1758	RNA polymerase activity
CLH39_RS09505	COG0194	GDP metabolic process
CLH39_RS09540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CLH39_RS09550	COG0183	Belongs to the thiolase family
CLH39_RS09555	COG0183	Belongs to the thiolase family
CLH39_RS09575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLH39_RS09580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_RS09585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLH39_RS09595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLH39_RS09615	COG0183	Belongs to the thiolase family
CLH39_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS09645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLH39_RS09650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS09655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_RS09660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS09675	COG0640	Transcriptional regulator
CLH39_RS09680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLH39_RS09690	COG1999	signal sequence binding
CLH39_RS09700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLH39_RS09705	COG4566	intracellular signal transduction
CLH39_RS09715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_RS09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_RS09725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLH39_RS09730	COG0285	dihydrofolate synthase activity
CLH39_RS09740	COG1286	toxin biosynthetic process
CLH39_RS09765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CLH39_RS09770	COG0024	Methionine aminopeptidase
CLH39_RS09775	COG0052	Belongs to the universal ribosomal protein uS2 family
CLH39_RS09780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLH39_RS09785	COG0528	UMP kinase activity
CLH39_RS09790	COG0233	cytoplasmic translational termination
CLH39_RS09795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLH39_RS09800	COG0575	Belongs to the CDS family
CLH39_RS09805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLH39_RS09815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLH39_RS09825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLH39_RS09830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLH39_RS09840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLH39_RS09845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLH39_RS09850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLH39_RS09875	COG1252	NADH dehydrogenase
CLH39_RS09880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLH39_RS09885	COG2867	negative regulation of translational initiation
CLH39_RS09890	COG2914	Belongs to the UPF0125 (RnfH) family
CLH39_RS09895	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS09910	COG0354	folic acid binding
CLH39_RS09915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLH39_RS09925	COG0470	DNA polymerase III
CLH39_RS09930	COG0084	hydrolase, TatD family'
CLH39_RS09950	COG0625	glutathione transferase activity
CLH39_RS09955	COG1393	Belongs to the ArsC family
CLH39_RS09960	COG2353	YceI-like domain
CLH39_RS09970	COG3038	cytochrome b561
CLH39_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS10015	COG2894	cell division
CLH39_RS10060	COG0583	DNA-binding transcription factor activity
CLH39_RS10105	COG4771	TonB-dependent receptor
CLH39_RS10120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLH39_RS10125	COG1335	isochorismatase
CLH39_RS10140	COG2814	Major facilitator Superfamily
CLH39_RS10185	COG2003	Belongs to the UPF0758 family
CLH39_RS10205	COG4774	siderophore transport
CLH39_RS10240	COG1858	cytochrome C peroxidase
CLH39_RS10250	COG4771	TonB-dependent receptor
CLH39_RS10275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_RS10290	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CLH39_RS10445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLH39_RS10450	COG2132	Multicopper oxidase
CLH39_RS10460	COG4974	Belongs to the 'phage' integrase family
CLH39_RS10465	COG0583	DNA-binding transcription factor activity
CLH39_RS10500	COG0583	DNA-binding transcription factor activity
CLH39_RS10510	COG2807	transmembrane transport
CLH39_RS10515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_RS10520	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_RS10530	COG0235	Class ii aldolase
CLH39_RS10535	COG2207	Transcriptional regulator
CLH39_RS10540	COG4654	Cytochrome c, class I
CLH39_RS10545	COG0589	response to stress
CLH39_RS10550	COG2226	methyltransferase
CLH39_RS10555	COG2133	pyrroloquinoline quinone binding
CLH39_RS10560	COG0114	fumarate hydratase activity
CLH39_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS10575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_RS10585	COG0625	glutathione transferase activity
CLH39_RS10605	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS10620	COG1653	transport
CLH39_RS10625	COG1175	transmembrane transport
CLH39_RS10630	COG0395	ABC-type sugar transport system, permease component
CLH39_RS10635	COG3842	ATPase activity
CLH39_RS10645	COG0783	Belongs to the Dps family
CLH39_RS10655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLH39_RS10670	COG1840	ABC-type Fe3 transport system, periplasmic component
CLH39_RS10675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLH39_RS10680	COG3842	ATPase activity
CLH39_RS10700	COG2153	protein acetylation
CLH39_RS10705	COG0174	glutamine synthetase
CLH39_RS10710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLH39_RS10715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLH39_RS10720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLH39_RS10735	COG1561	YicC-like family, N-terminal region
CLH39_RS10770	COG2814	Major facilitator Superfamily
CLH39_RS10780	COG1473	amidohydrolase
CLH39_RS10785	COG0071	Belongs to the small heat shock protein (HSP20) family
CLH39_RS10790	COG2233	PERMEase
CLH39_RS10840	COG1053	succinate dehydrogenase
CLH39_RS10845	COG0583	DNA-binding transcription factor activity
CLH39_RS10855	COG4191	Histidine kinase
CLH39_RS10860	COG1301	dicarboxylic acid transport
CLH39_RS10875	COG0307	riboflavin synthase, alpha
CLH39_RS10885	COG4221	oxidoreductase activity
CLH39_RS10890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS10905	COG1360	Flagellar Motor Protein
CLH39_RS10920	COG1686	Belongs to the peptidase S11 family
CLH39_RS10925	COG0583	DNA-binding transcription factor activity
CLH39_RS10965	COG0587	DNA-directed DNA polymerase activity
CLH39_RS10970	COG1610	YqeY-like protein
CLH39_RS10980	COG1902	pentaerythritol trinitrate reductase activity
CLH39_RS10985	COG0569	domain protein
CLH39_RS10990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLH39_RS11005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_RS11015	COG3949	Membrane
CLH39_RS11030	COG3258	Cytochrome c
CLH39_RS11035	COG3048	D-serine ammonia-lyase activity
CLH39_RS11040	COG2207	Transcriptional regulator
CLH39_RS11045	COG0604	alcohol dehydrogenase
CLH39_RS11155	COG2948	multi-organism process
CLH39_RS11190	COG0433	COG0433 Predicted ATPase
CLH39_RS11255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLH39_RS11265	COG4172	Belongs to the ABC transporter superfamily
CLH39_RS11270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_RS11275	COG0601	transmembrane transport
CLH39_RS11280	COG0747	negative chemotaxis
CLH39_RS11305	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLH39_RS11310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLH39_RS11315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLH39_RS11340	COG2274	protein secretion by the type I secretion system
CLH39_RS11350	COG1538	Outer membrane efflux protein
CLH39_RS11370	COG2151	metal-sulfur cluster biosynthetic enzyme
CLH39_RS11375	COG0822	iron-sulfur transferase activity
CLH39_RS11385	COG0719	Fe-S assembly protein
CLH39_RS11390	COG0396	ATPase activity
CLH39_RS11395	COG0719	Fe-S assembly protein
CLH39_RS11400	COG1959	2 iron, 2 sulfur cluster binding
CLH39_RS11405	COG5265	(ABC) transporter
CLH39_RS11420	COG2833	Protein of unknown function (DUF455)
CLH39_RS11435	COG0072	phenylalanine-tRNA ligase activity
CLH39_RS11435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_RS11440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLH39_RS11445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLH39_RS11450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLH39_RS11480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLH39_RS11485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLH39_RS11500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLH39_RS11505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLH39_RS11520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLH39_RS11530	COG3042	response to heat
CLH39_RS11540	COG2226	methyltransferase
CLH39_RS11545	COG1585	Membrane protein implicated in regulation of membrane protease activity
CLH39_RS11550	COG0330	HflC and HflK could
CLH39_RS11575	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_RS11585	COG1609	Transcriptional regulator
CLH39_RS11590	COG1280	lysine exporter protein (LysE YggA)
CLH39_RS11595	COG2814	Major facilitator Superfamily
CLH39_RS11625	COG2871	sodium ion transport
CLH39_RS11680	COG1126	abc transporter atp-binding protein
CLH39_RS11685	COG0765	amino acid transport
CLH39_RS11690	COG0765	amino acid transport
CLH39_RS11695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS11720	COG3422	double-strand break repair
CLH39_RS11725	COG1272	protein, Hemolysin III
CLH39_RS11745	COG3772	lysozyme
CLH39_RS11820	COG2856	Zn peptidase
CLH39_RS11870	COG5410	chromosome segregation
CLH39_RS11875	COG3728	DNA packaging
CLH39_RS11875	COG5484	DNA packaging
CLH39_RS12035	COG0582	viral genome integration into host DNA
CLH39_RS12055	COG0667	Aldo Keto reductase
CLH39_RS12060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLH39_RS12090	COG3842	ATPase activity
CLH39_RS12110	COG0697	spore germination
CLH39_RS12120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLH39_RS12130	COG2271	Major facilitator Superfamily
CLH39_RS12135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_RS12140	COG1846	Transcriptional regulator
CLH39_RS12165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLH39_RS12180	COG4555	ABC transporter
CLH39_RS12190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLH39_RS12195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLH39_RS12200	COG3135	benzoate transporter
CLH39_RS12210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLH39_RS12215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLH39_RS12225	COG3485	protocatechuate 3,4-dioxygenase
CLH39_RS12250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_RS12275	COG0640	Transcriptional regulator
CLH39_RS12305	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS12315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_RS12365	COG0740	serine-type endopeptidase activity
CLH39_RS12370	COG0625	glutathione transferase activity
CLH39_RS12375	COG2816	NAD+ diphosphatase activity
CLH39_RS12395	COG0583	DNA-binding transcription factor activity
CLH39_RS12400	COG0625	glutathione transferase activity
CLH39_RS12415	COG1309	transcriptional regulator
CLH39_RS12450	COG2070	2-Nitropropane dioxygenase
CLH39_RS12465	COG1942	4-Oxalocrotonate Tautomerase
CLH39_RS12475	COG1566	PFAM secretion protein HlyD family protein
CLH39_RS12485	COG1289	transmembrane transporter activity
CLH39_RS12490	COG0583	DNA-binding transcription factor activity
CLH39_RS12510	COG2207	Transcriptional regulator
CLH39_RS12515	COG0745	RESPONSE REGULATOR receiver
CLH39_RS12535	COG1078	dGTPase activity
CLH39_RS12555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLH39_RS12560	COG0735	belongs to the Fur family
CLH39_RS12565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLH39_RS12575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLH39_RS12580	COG1469	GTP cyclohydrolase I activity
CLH39_RS12585	COG0523	cobalamin synthesis protein
CLH39_RS12590	COG2378	regulation of single-species biofilm formation
CLH39_RS12600	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS12610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLH39_RS12625	COG0583	DNA-binding transcription factor activity
CLH39_RS12630	COG3328	transposase activity
CLH39_RS12660	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_RS12660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLH39_RS12685	COG0047	phosphoribosylformylglycinamidine synthase activity
CLH39_RS12685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLH39_RS12695	COG0613	PHP domain protein
CLH39_RS12710	COG0084	hydrolase, TatD family'
CLH39_RS12715	COG1136	(ABC) transporter
CLH39_RS12730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLH39_RS12755	COG3210	domain, Protein
CLH39_RS12760	COG2831	hemolysin activation secretion protein
CLH39_RS12770	COG0385	Bile acid
CLH39_RS12775	COG0697	spore germination
CLH39_RS12780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLH39_RS12785	COG0840	transmembrane signaling receptor activity
CLH39_RS12795	COG4221	oxidoreductase activity
CLH39_RS12800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLH39_RS12805	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS12815	COG0316	Belongs to the HesB IscA family
CLH39_RS12825	COG1104	cysteine desulfurase activity
CLH39_RS12835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLH39_RS12840	COG0556	nucleotide-excision repair
CLH39_RS12860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLH39_RS12870	COG0740	serine-type endopeptidase activity
CLH39_RS12875	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLH39_RS12880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_RS12895	COG0789	Transcriptional regulator
CLH39_RS12935	COG3273	potassium ion transport
CLH39_RS12935	COG0471	metal ion transport
CLH39_RS12945	COG2207	Transcriptional regulator
CLH39_RS12955	COG2171	N-acyltransferase activity
CLH39_RS12960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLH39_RS12965	COG2890	protein-(glutamine-N5) methyltransferase activity
CLH39_RS12970	COG0488	(ABC) transporter
CLH39_RS13025	COG0210	DNA helicase
CLH39_RS13035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLH39_RS13035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLH39_RS13040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLH39_RS13045	COG0196	riboflavin kinase activity
CLH39_RS13050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLH39_RS13055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLH39_RS13065	COG0756	dUTP diphosphatase activity
CLH39_RS13070	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CLH39_RS13080	COG0300	oxidoreductase activity
CLH39_RS13115	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS13135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLH39_RS13135	COG3008	intermembrane lipid transfer
CLH39_RS13140	COG2995	paraquat-inducible protein a
CLH39_RS13145	COG0542	response to heat
CLH39_RS13150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLH39_RS13155	COG1278	Cold shock
CLH39_RS13165	COG0183	Belongs to the thiolase family
CLH39_RS13180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLH39_RS13185	COG1570	exodeoxyribonuclease VII activity
CLH39_RS13190	COG0811	peptide transport
CLH39_RS13195	COG0848	biopolymer transport protein
CLH39_RS13200	COG1663	tetraacyldisaccharide 4'-kinase activity
CLH39_RS13205	COG2835	tetraacyldisaccharide 4'-kinase activity
CLH39_RS13210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLH39_RS13215	COG0563	adenylate kinase activity
CLH39_RS13225	COG0728	peptidoglycan biosynthetic process
CLH39_RS13230	COG0268	Binds directly to 16S ribosomal RNA
CLH39_RS13235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLH39_RS13245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLH39_RS13250	COG0745	RESPONSE REGULATOR receiver
CLH39_RS13255	COG2205	protein histidine kinase activity
CLH39_RS13270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CLH39_RS13280	COG0519	Catalyzes the synthesis of GMP from XMP
CLH39_RS13285	COG1609	Transcriptional regulator
CLH39_RS13305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_RS13310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLH39_RS13315	COG0137	argininosuccinate synthase activity
CLH39_RS13325	COG2832	Protein of unknown function (DUF454)
CLH39_RS13330	COG0494	nUDIX hydrolase
CLH39_RS13340	COG0626	cystathionine gamma-synthase activity
CLH39_RS13345	COG1522	sequence-specific DNA binding
CLH39_RS13360	COG2199	diguanylate cyclase activity
CLH39_RS13415	COG3772	lysozyme
CLH39_RS13515	COG2161	toxin-antitoxin pair type II binding
CLH39_RS13520	COG4115	mRNA cleavage
CLH39_RS13535	COG0501	Belongs to the peptidase M48B family
CLH39_RS13545	COG0456	acetyltransferase
CLH39_RS13560	COG1490	D-aminoacyl-tRNA deacylase activity
CLH39_RS13575	COG2239	Acts as a magnesium transporter
CLH39_RS13580	COG0784	Response regulator, receiver
CLH39_RS13580	COG2198	Histidine kinase
CLH39_RS13580	COG2205	protein histidine kinase activity
CLH39_RS13585	COG3437	response regulator, receiver
CLH39_RS13590	COG1396	sequence-specific DNA binding
CLH39_RS13605	COG0477	Major facilitator Superfamily
CLH39_RS13610	COG1196	nuclear chromosome segregation
CLH39_RS13610	COG3264	Mechanosensitive ion channel
CLH39_RS13620	COG3264	Mechanosensitive ion channel
CLH39_RS13620	COG1511	domain protein
CLH39_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS13670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLH39_RS13675	COG1058	Belongs to the CinA family
CLH39_RS13675	COG1546	Belongs to the CinA family
CLH39_RS13680	COG1846	Transcriptional regulator
CLH39_RS13690	COG0069	glutamate synthase activity
CLH39_RS13705	COG1999	signal sequence binding
CLH39_RS13725	COG2252	PERMEase
CLH39_RS13730	COG1289	transmembrane transporter activity
CLH39_RS13745	COG0025	NhaP-type Na H and K H
CLH39_RS13780	COG4774	siderophore transport
CLH39_RS13785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLH39_RS13790	COG3258	Cytochrome c
CLH39_RS13805	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_RS13815	COG0642	Histidine kinase
CLH39_RS13820	COG1278	Cold shock
CLH39_RS13845	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_RS13885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLH39_RS13890	COG3755	Protein conserved in bacteria
CLH39_RS13915	COG1113	amino acid transport
CLH39_RS13925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS13935	COG1858	cytochrome C peroxidase
CLH39_RS13940	COG4771	TonB-dependent receptor
CLH39_RS13955	COG2824	Alkylphosphonate utilization operon protein PhnA
CLH39_RS13965	COG0583	DNA-binding transcription factor activity
CLH39_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS13975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_RS13980	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_RS13985	COG4521	taurine ABC transporter
CLH39_RS13990	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLH39_RS14035	COG0582	viral genome integration into host DNA
CLH39_RS14045	COG2610	gluconate transmembrane transporter activity
CLH39_RS14055	COG2080	2 iron, 2 sulfur cluster binding
CLH39_RS14065	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS14080	COG0840	transmembrane signaling receptor activity
CLH39_RS14085	COG0840	transmembrane signaling receptor activity
CLH39_RS14090	COG2733	membrane
CLH39_RS14110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_RS14120	COG1136	(ABC) transporter
CLH39_RS14160	COG1191	sigma factor activity
CLH39_RS14165	COG1334	flagellar protein FlaG
CLH39_RS14170	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLH39_RS14190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLH39_RS14195	COG1677	Flagellar hook-basal body complex protein FliE
CLH39_RS14200	COG1766	The M ring may be actively involved in energy transduction
CLH39_RS14215	COG1157	protein secretion by the type III secretion system
CLH39_RS14230	COG1580	Controls the rotational direction of flagella during chemotaxis
CLH39_RS14240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLH39_RS14255	COG1987	bacterial-type flagellum assembly
CLH39_RS14265	COG2176	DNA-directed DNA polymerase activity
CLH39_RS14290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLH39_RS14330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLH39_RS14335	COG1558	bacterial-type flagellum-dependent cell motility
CLH39_RS14365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLH39_RS14375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CLH39_RS14380	COG0745	RESPONSE REGULATOR receiver
CLH39_RS14390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLH39_RS14395	COG0840	transmembrane signaling receptor activity
CLH39_RS14400	COG0835	chemotaxis
CLH39_RS14410	COG1360	Flagellar Motor Protein
CLH39_RS14430	COG0791	NLP P60 protein
CLH39_RS14435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CLH39_RS14440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLH39_RS14445	COG2314	TM2 domain
CLH39_RS14455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLH39_RS14460	COG0659	secondary active sulfate transmembrane transporter activity
CLH39_RS14485	COG0640	Transcriptional regulator
CLH39_RS14495	COG3094	Invasion gene expression up-regulator, SirB
CLH39_RS14525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS14540	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLH39_RS14545	COG0628	permease
CLH39_RS14580	COG0277	FAD linked oxidase domain protein
CLH39_RS14585	COG0277	FAD linked oxidase domain protein
CLH39_RS14590	COG2186	Transcriptional regulator
CLH39_RS14645	COG1132	(ABC) transporter
CLH39_RS14670	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS14685	COG0726	polysaccharide deacetylase
CLH39_RS14690	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS14700	COG1643	Atp-dependent helicase
CLH39_RS14705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLH39_RS14705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLH39_RS14710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CLH39_RS14715	COG4251	negative regulation of phosphorylation
CLH39_RS14715	COG2203	Gaf domain
CLH39_RS14715	COG3706	GGDEF domain
CLH39_RS14715	COG5001	Diguanylate cyclase
CLH39_RS14720	COG0704	Plays a role in the regulation of phosphate uptake
CLH39_RS14725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLH39_RS14730	COG1393	Belongs to the ArsC family
CLH39_RS14735	COG1177	transmembrane transport
CLH39_RS14740	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLH39_RS14745	COG3842	ATPase activity
CLH39_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS14775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLH39_RS14780	COG1562	ergosterol biosynthetic process
CLH39_RS14785	COG1562	ergosterol biosynthetic process
CLH39_RS14790	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLH39_RS14795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLH39_RS14810	COG0436	Aminotransferase
CLH39_RS14820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLH39_RS14825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLH39_RS14830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLH39_RS14840	COG0305	Participates in initiation and elongation during chromosome replication
CLH39_RS14850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLH39_RS14855	COG2965	DNA replication, synthesis of RNA primer
CLH39_RS14860	COG0360	Binds together with S18 to 16S ribosomal RNA
CLH39_RS14865	COG1469	GTP cyclohydrolase I activity
CLH39_RS14870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLH39_RS14875	COG0142	geranyltranstransferase activity
CLH39_RS14880	COG1722	exodeoxyribonuclease VII activity
CLH39_RS14900	COG0501	Belongs to the peptidase M48B family
CLH39_RS14920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLH39_RS14930	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLH39_RS14950	COG4215	(ABC) transporter
CLH39_RS14955	COG4160	amino acid transport
CLH39_RS14965	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLH39_RS14970	COG1217	gtp-binding protein TYPA
CLH39_RS14975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLH39_RS14980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLH39_RS14990	COG2251	uridine kinase activity
CLH39_RS14990	COG0195	Participates in both transcription termination and antitermination
CLH39_RS14995	COG0779	Required for maturation of 30S ribosomal subunits
CLH39_RS15000	COG1187	pseudouridine synthase activity
CLH39_RS15005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLH39_RS15045	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CLH39_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS15055	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLH39_RS15065	COG0564	pseudouridine synthase activity
CLH39_RS15090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS15095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLH39_RS15095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_RS15110	COG1733	regulation of RNA biosynthetic process
CLH39_RS15120	COG1199	ATP-dependent helicase activity
CLH39_RS15125	COG2183	response to ionizing radiation
CLH39_RS15145	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CLH39_RS15150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLH39_RS15155	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLH39_RS15160	COG0567	Dehydrogenase, E1 component
CLH39_RS15165	COG0281	malic enzyme
CLH39_RS15165	COG0280	phosphate acetyltransferase
CLH39_RS15175	COG0038	chloride channel
CLH39_RS15180	COG1620	l-lactate permease
CLH39_RS15185	COG2186	Transcriptional regulator
CLH39_RS15190	COG0372	Belongs to the citrate synthase family
CLH39_RS15195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CLH39_RS15200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLH39_RS15205	COG1053	succinate dehydrogenase
CLH39_RS15215	COG2009	succinate dehydrogenase
CLH39_RS15220	COG2188	Transcriptional regulator
CLH39_RS15225	COG0039	L-malate dehydrogenase activity
CLH39_RS15245	COG3829	transcription factor binding
CLH39_RS15275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS15300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLH39_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS15320	COG0183	Belongs to the thiolase family
CLH39_RS15330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS15350	COG1454	alcohol dehydrogenase
CLH39_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_RS15360	COG3284	Transcriptional regulator
CLH39_RS15370	COG4172	Belongs to the ABC transporter superfamily
CLH39_RS15375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLH39_RS15395	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS15400	COG0598	Magnesium transport protein CorA
CLH39_RS15405	COG2363	Small membrane protein
CLH39_RS15410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLH39_RS15415	COG2094	Belongs to the DNA glycosylase MPG family
CLH39_RS15430	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLH39_RS15435	COG0435	Glutathione S-transferase
CLH39_RS15440	COG1304	FMN binding
CLH39_RS15455	COG4773	Receptor
CLH39_RS15485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLH39_RS15495	COG3842	ATPase activity
CLH39_RS15500	COG4208	sulfate ABC transporter
CLH39_RS15520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLH39_RS15535	COG0330	HflC and HflK could
CLH39_RS15560	COG0037	tRNA processing
CLH39_RS15565	COG0825	malonyl-CoA metabolic process
CLH39_RS15575	COG0215	cysteine-tRNA ligase activity
CLH39_RS15595	COG1968	undecaprenyl-diphosphatase activity
CLH39_RS15600	COG1253	flavin adenine dinucleotide binding
CLH39_RS15605	COG0483	inositol monophosphate 1-phosphatase activity
CLH39_RS15620	COG2031	fatty acid transporter
CLH39_RS15625	COG0154	amidase activity
CLH39_RS15660	COG3321	synthase
CLH39_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS15660	COG0604	alcohol dehydrogenase
CLH39_RS15670	COG0668	transmembrane transport
CLH39_RS15680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLH39_RS15690	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS15700	COG1132	(ABC) transporter
CLH39_RS15705	COG0363	glucosamine-6-phosphate deaminase activity
CLH39_RS15710	COG1538	Outer membrane efflux protein
CLH39_RS15715	COG1136	(ABC) transporter
CLH39_RS15715	COG0577	efflux transmembrane transporter activity
CLH39_RS15720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLH39_RS15730	COG3391	amine dehydrogenase activity
CLH39_RS15740	COG2850	peptidyl-arginine hydroxylation
CLH39_RS15745	COG3135	benzoate transporter
CLH39_RS15750	COG2124	cytochrome p450
CLH39_RS15755	COG0156	8-amino-7-oxononanoate synthase activity
CLH39_RS15765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLH39_RS15780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CLH39_RS15785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_RS15790	COG1994	Peptidase M50
CLH39_RS15795	COG0009	L-threonylcarbamoyladenylate synthase
CLH39_RS15810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLH39_RS15815	COG3327	negative regulation of DNA-templated transcription, initiation
CLH39_RS15820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLH39_RS15850	COG1368	sulfuric ester hydrolase activity
CLH39_RS15865	COG2323	membrane
CLH39_RS15870	COG2010	Cytochrome c
CLH39_RS15925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLH39_RS15930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLH39_RS15950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLH39_RS15955	COG0248	Ppx GppA phosphatase
CLH39_RS15965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLH39_RS15975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLH39_RS15980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CLH39_RS15985	COG1534	Rna-binding protein
CLH39_RS15990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLH39_RS16000	COG2233	PERMEase
CLH39_RS16020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLH39_RS16025	COG0505	Belongs to the CarA family
CLH39_RS16030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLH39_RS16035	COG3391	amine dehydrogenase activity
CLH39_RS16055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_RS16090	COG1074	ATP-dependent DNA helicase activity
CLH39_RS16105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLH39_RS16110	COG4149	molybdate abc transporter
CLH39_RS16115	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLH39_RS16120	COG4974	Belongs to the 'phage' integrase family
CLH39_RS16125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLH39_RS16130	COG2223	nitrite transmembrane transporter activity
CLH39_RS16140	COG2910	NAD(P)H-binding
CLH39_RS16145	COG1733	regulation of RNA biosynthetic process
CLH39_RS16170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS16190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_RS16200	COG0583	DNA-binding transcription factor activity
CLH39_RS16205	COG0281	malic enzyme
CLH39_RS16205	COG0280	phosphate acetyltransferase
CLH39_RS16210	COG0463	Glycosyl transferase, family 2
CLH39_RS16245	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS16255	COG0802	atpase or kinase
CLH39_RS16260	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLH39_RS16265	COG0586	Pfam SNARE associated Golgi protein
CLH39_RS16270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLH39_RS16275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLH39_RS16280	COG1953	Uracil, thiamine, allantoin
CLH39_RS16290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLH39_RS16295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLH39_RS16305	COG0617	tRNA 3'-terminal CCA addition
CLH39_RS16310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLH39_RS16315	COG1573	uracil-dna glycosylase
CLH39_RS16330	COG2814	Major facilitator Superfamily
CLH39_RS16340	COG1309	transcriptional regulator
CLH39_RS16360	COG0752	glycyl-tRNA synthetase alpha subunit
CLH39_RS16365	COG0751	glycine-tRNA ligase activity
CLH39_RS16370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLH39_RS16375	COG0204	Acyl-transferase
CLH39_RS16390	COG0700	Nucleoside recognition
CLH39_RS16395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLH39_RS16400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_RS16405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLH39_RS16425	COG1126	abc transporter atp-binding protein
CLH39_RS16430	COG0765	amino acid transport
CLH39_RS16435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS16445	COG2011	ABC-type metal ion transport system permease component
CLH39_RS16450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLH39_RS16465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLH39_RS16465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLH39_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
CLH39_RS16480	COG1473	amidohydrolase
CLH39_RS16490	COG2239	Acts as a magnesium transporter
CLH39_RS16500	COG0653	protein targeting
CLH39_RS16505	COG0739	heme binding
CLH39_RS16505	COG0741	lytic transglycosylase activity
CLH39_RS16505	COG1196	nuclear chromosome segregation
CLH39_RS16515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLH39_RS16530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLH39_RS16535	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLH39_RS16540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLH39_RS16545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLH39_RS16555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLH39_RS16560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLH39_RS16565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLH39_RS16575	COG3116	cell division
CLH39_RS16580	COG0275	rRNA processing
CLH39_RS16585	COG2001	Belongs to the MraZ family
CLH39_RS16595	COG0488	(ABC) transporter
CLH39_RS16600	COG0633	Ferredoxin
CLH39_RS16605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLH39_RS16610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLH39_RS16615	COG0514	ATP-dependent DNA helicase (RecQ)
CLH39_RS16625	COG0038	chloride channel
CLH39_RS16630	COG1294	oxidase, subunit
CLH39_RS16635	COG1271	oxidase subunit
CLH39_RS16640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLH39_RS16650	COG2894	cell division
CLH39_RS16655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLH39_RS16675	COG0488	(ABC) transporter
CLH39_RS16685	COG1215	transferase activity, transferring glycosyl groups
CLH39_RS16690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLH39_RS16705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLH39_RS16715	COG0259	pyridoxamine-phosphate oxidase activity
CLH39_RS16720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_RS16725	COG0579	oxidoreductase
CLH39_RS16735	COG0405	Gamma-glutamyltransferase
CLH39_RS16745	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS16750	COG2030	dehydratase
CLH39_RS16750	COG1012	belongs to the aldehyde dehydrogenase family
CLH39_RS16755	COG0596	Alpha beta hydrolase
CLH39_RS16760	COG0009	L-threonylcarbamoyladenylate synthase
CLH39_RS16765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLH39_RS16770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLH39_RS16775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLH39_RS16785	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLH39_RS16810	COG0126	phosphoglycerate kinase activity
CLH39_RS16815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLH39_RS16820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLH39_RS16825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLH39_RS16830	COG2732	(Barnase) inhibitor
CLH39_RS16840	COG0280	phosphate acetyltransferase
CLH39_RS16840	COG0281	malic enzyme
CLH39_RS16850	COG0436	Aminotransferase
CLH39_RS16860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLH39_RS16875	COG0477	Major facilitator Superfamily
CLH39_RS16885	COG0154	amidase activity
CLH39_RS16900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLH39_RS16915	COG0583	DNA-binding transcription factor activity
CLH39_RS16930	COG4575	ribosome binding
CLH39_RS16940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLH39_RS16945	COG2027	D-alanyl-D-alanine carboxypeptidase
CLH39_RS16950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLH39_RS16955	COG0343	queuine tRNA-ribosyltransferase activity
CLH39_RS16960	COG1862	Preprotein translocase
CLH39_RS16965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLH39_RS16970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLH39_RS16975	COG0024	Methionine aminopeptidase
CLH39_RS16985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLH39_RS16990	COG1702	phosphate starvation-inducible protein PhoH
CLH39_RS16995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLH39_RS17000	COG4535	Mg2 and Co2 transporter CorC
CLH39_RS17005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLH39_RS17045	COG2814	Major facilitator Superfamily
CLH39_RS17080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLH39_RS17085	COG0697	spore germination
CLH39_RS17100	COG0678	peroxiredoxin activity
CLH39_RS17130	COG0315	cyclic pyranopterin monophosphate synthase activity
CLH39_RS17140	COG0314	molybdopterin synthase activity
CLH39_RS17145	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLH39_RS17150	COG0303	'Molybdopterin
CLH39_RS17160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLH39_RS17165	COG1910	domain protein
CLH39_RS17180	COG3383	formate dehydrogenase (NAD+) activity
CLH39_RS17185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLH39_RS17225	COG0463	Glycosyl transferase, family 2
CLH39_RS17230	COG2346	COG2346, Truncated hemoglobins
CLH39_RS17235	COG1959	2 iron, 2 sulfur cluster binding
CLH39_RS17240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLH39_RS17245	COG1858	cytochrome C peroxidase
CLH39_RS17255	COG0411	ABC transporter
CLH39_RS17265	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS17285	COG2169	Transcriptional regulator
CLH39_RS17285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_RS17295	COG0785	Cytochrome C biogenesis protein
CLH39_RS17300	COG4235	cytochrome complex assembly
CLH39_RS17305	COG3088	subunit of a heme lyase
CLH39_RS17310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLH39_RS17320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLH39_RS17330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLH39_RS17350	COG0583	DNA-binding transcription factor activity
CLH39_RS17355	COG0288	reversible hydration of carbon dioxide
CLH39_RS17370	COG0488	(ABC) transporter
CLH39_RS17390	COG0012	GTP binding
CLH39_RS17400	COG0193	aminoacyl-tRNA hydrolase activity
CLH39_RS17405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLH39_RS17410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLH39_RS17425	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CLH39_RS17435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLH39_RS17445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_RS17455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CLH39_RS17460	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLH39_RS17470	COG0277	FAD linked oxidase domain protein
CLH39_RS17480	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS17485	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS17490	COG0438	transferase activity, transferring glycosyl groups
CLH39_RS17505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLH39_RS17510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLH39_RS17520	COG3195	allantoin biosynthetic process
CLH39_RS17520	COG3648	Uricase
CLH39_RS17525	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CLH39_RS17530	COG0235	Class ii aldolase
CLH39_RS17535	COG1942	4-Oxalocrotonate Tautomerase
CLH39_RS17540	COG2233	PERMEase
CLH39_RS17550	COG0583	DNA-binding transcription factor activity
CLH39_RS17555	COG3960	tartronate-semialdehyde synthase activity
CLH39_RS17560	COG3622	Belongs to the hyi family
CLH39_RS17565	COG2084	Dehydrogenase
CLH39_RS17575	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CLH39_RS17580	COG0469	pyruvate kinase activity
CLH39_RS17585	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CLH39_RS17610	COG3278	Belongs to the heme-copper respiratory oxidase family
CLH39_RS17615	COG1765	OsmC-like protein
CLH39_RS17620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLH39_RS17630	COG0509	glycine decarboxylation via glycine cleavage system
CLH39_RS17635	COG2081	HI0933 family
CLH39_RS17660	COG0489	protein tyrosine kinase activity
CLH39_RS17670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_RS17670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLH39_RS17675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLH39_RS17680	COG0583	DNA-binding transcription factor activity
CLH39_RS17685	COG3257	ureidoglycine aminohydrolase activity
CLH39_RS17690	COG0590	tRNA wobble adenosine to inosine editing
CLH39_RS17695	COG3391	amine dehydrogenase activity
CLH39_RS17710	COG0235	Class ii aldolase
CLH39_RS17715	COG0477	Major facilitator Superfamily
CLH39_RS17730	COG0387	Pfam Sodium calcium exchanger
CLH39_RS17740	COG0583	DNA-binding transcription factor activity
CLH39_RS17765	COG3433	isochorismatase activity
CLH39_RS17765	COG1535	isochorismatase
CLH39_RS17785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLH39_RS17800	COG1652	LysM domain
CLH39_RS17805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLH39_RS17820	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLH39_RS17825	COG0326	Molecular chaperone. Has ATPase activity
CLH39_RS17850	COG0583	DNA-binding transcription factor activity
CLH39_RS17860	COG0154	amidase activity
CLH39_RS17875	COG0477	Major facilitator Superfamily
CLH39_RS17885	COG4948	Mandelate Racemase Muconate Lactonizing
CLH39_RS17895	COG1418	mRNA catabolic process
CLH39_RS17905	COG1671	Belongs to the UPF0178 family
CLH39_RS17915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLH39_RS17920	COG0861	Integral membrane protein TerC family
CLH39_RS17945	COG0395	ABC-type sugar transport system, permease component
CLH39_RS17960	COG3842	ATPase activity
CLH39_RS17965	COG1349	DNA-binding transcription factor activity
CLH39_RS17990	COG1113	amino acid transport
CLH39_RS17995	COG3844	kynureninase activity
CLH39_RS18000	COG1522	sequence-specific DNA binding
CLH39_RS18005	COG1609	Transcriptional regulator
CLH39_RS18025	COG2186	Transcriptional regulator
CLH39_RS18030	COG1304	FMN binding
CLH39_RS18035	COG0277	FAD linked oxidase domain protein
CLH39_RS18040	COG1132	(ABC) transporter
CLH39_RS18040	COG2375	cellular response to nickel ion
CLH39_RS18045	COG1132	(ABC) transporter
CLH39_RS18050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_RS18055	COG4605	iron ion homeostasis
CLH39_RS18060	COG4604	ABC transporter, ATP-binding protein
CLH39_RS18065	COG4607	ABC-type enterochelin transport system periplasmic component
CLH39_RS18070	COG4774	siderophore transport
CLH39_RS18085	COG0583	DNA-binding transcription factor activity
CLH39_RS18090	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLH39_RS18095	COG2814	Major facilitator Superfamily
CLH39_RS18100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLH39_RS18125	COG3685	Protein conserved in bacteria
CLH39_RS18135	COG0583	DNA-binding transcription factor activity
CLH39_RS18140	COG2814	Major facilitator Superfamily
CLH39_RS18145	COG0656	L-ascorbic acid biosynthetic process
CLH39_RS18155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CLH39_RS18160	COG1196	nuclear chromosome segregation
CLH39_RS18245	COG0628	permease
CLH39_RS18250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLH39_RS18265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_RS18265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS18275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS18285	COG0129	dihydroxy-acid dehydratase activity
CLH39_RS18290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLH39_RS18295	COG0730	response to heat
CLH39_RS18335	COG1950	PFAM Membrane protein of
CLH39_RS18340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLH39_RS18345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLH39_RS18355	COG1560	Kdo2-lipid A biosynthetic process
CLH39_RS18360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLH39_RS18370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLH39_RS18375	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLH39_RS18380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLH39_RS18395	COG0735	belongs to the Fur family
CLH39_RS18400	COG0523	cobalamin synthesis protein
CLH39_RS18410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLH39_RS18415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLH39_RS18430	COG2096	Adenosyltransferase
CLH39_RS18445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLH39_RS18460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLH39_RS18470	COG1280	lysine exporter protein (LysE YggA)
CLH39_RS18490	COG0251	oxidation-reduction process
CLH39_RS18505	COG1346	cytolysis
CLH39_RS18510	COG2860	membrane
CLH39_RS18515	COG2223	nitrite transmembrane transporter activity
CLH39_RS18525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLH39_RS18530	COG2197	response regulator
CLH39_RS18540	COG2918	glutathione biosynthetic process
CLH39_RS18570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_RS18575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_RS18585	COG1024	Enoyl-CoA hydratase
CLH39_RS18590	COG0070	glutamate synthase
CLH39_RS18590	COG0067	glutamate synthase
CLH39_RS18590	COG0069	glutamate synthase activity
CLH39_RS18605	COG0210	DNA helicase
CLH39_RS18610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLH39_RS18615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLH39_RS18640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLH39_RS18650	COG3391	amine dehydrogenase activity
CLH39_RS18665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLH39_RS18670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLH39_RS18675	COG0765	amino acid transport
CLH39_RS18680	COG0765	amino acid transport
CLH39_RS18685	COG1126	abc transporter atp-binding protein
CLH39_RS18690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS18695	COG0583	DNA-binding transcription factor activity
CLH39_RS18705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLH39_RS18710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_RS18715	COG0402	S-adenosylhomocysteine deaminase activity
CLH39_RS18730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLH39_RS18750	COG0456	acetyltransferase
CLH39_RS18760	COG1132	(ABC) transporter
CLH39_RS18770	COG2311	Membrane
CLH39_RS18785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLH39_RS18795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLH39_RS18820	COG1253	flavin adenine dinucleotide binding
CLH39_RS18830	COG0583	DNA-binding transcription factor activity
CLH39_RS18840	COG2814	Major facilitator Superfamily
CLH39_RS18845	COG0513	Belongs to the DEAD box helicase family
CLH39_RS18850	COG2819	hydrolase of the alpha beta superfamily
CLH39_RS18855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLH39_RS18860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CLH39_RS18880	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLH39_RS18895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLH39_RS18910	COG0683	leucine binding
CLH39_RS18940	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLH39_RS18945	COG1535	isochorismatase
CLH39_RS18945	COG3433	isochorismatase activity
CLH39_RS18950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLH39_RS18965	COG1169	isochorismate synthase
CLH39_RS18970	COG1535	isochorismatase
CLH39_RS18970	COG3433	isochorismatase activity
CLH39_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
CLH39_RS18985	COG0840	transmembrane signaling receptor activity
CLH39_RS18995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_RS19000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLH39_RS19005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CLH39_RS19010	COG2967	ApaG domain
CLH39_RS19015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLH39_RS19025	COG0546	phosphoglycolate phosphatase activity
CLH39_RS19035	COG0512	Glutamine amidotransferase of anthranilate synthase
CLH39_RS19040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLH39_RS19045	COG0134	indole-3-glycerol-phosphate synthase activity
CLH39_RS19070	COG3154	lipid carrier protein
CLH39_RS19080	COG0826	peptidase U32
CLH39_RS19125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLH39_RS19135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLH39_RS19140	COG1024	Enoyl-CoA hydratase
CLH39_RS19145	COG0321	lipoyl(octanoyl) transferase activity
CLH39_RS19150	COG2921	Belongs to the UPF0250 family
CLH39_RS19160	COG1686	Belongs to the peptidase S11 family
CLH39_RS19170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLH39_RS19170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLH39_RS19175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLH39_RS19180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLH39_RS19185	COG1278	Cold shock
CLH39_RS19195	COG0859	PFAM glycosyl transferase family 9
CLH39_RS19200	COG0583	DNA-binding transcription factor activity
CLH39_RS19205	COG4336	lyase activity
CLH39_RS19220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS19235	COG0697	spore germination
CLH39_RS19240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLH39_RS19245	COG0242	peptide deformylase activity
CLH39_RS19250	COG0758	DNA mediated transformation
CLH39_RS19265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLH39_RS19290	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLH39_RS19310	COG3181	Tripartite tricarboxylate transporter family receptor
CLH39_RS19315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLH39_RS19320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLH39_RS19345	COG0252	asparaginase activity
CLH39_RS19350	COG0564	pseudouridine synthase activity
CLH39_RS19360	COG2358	TRAP transporter, solute receptor (TAXI family
CLH39_RS19370	COG1254	Belongs to the acylphosphatase family
CLH39_RS19385	COG3093	addiction module antidote protein HigA
CLH39_RS19405	COG0583	DNA-binding transcription factor activity
CLH39_RS19435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS19445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLH39_RS19450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLH39_RS19470	COG1127	ABC transporter
CLH39_RS19475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLH39_RS19505	COG0583	DNA-binding transcription factor activity
CLH39_RS19520	COG0154	amidase activity
CLH39_RS19535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLH39_RS19550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLH39_RS19560	COG0513	Belongs to the DEAD box helicase family
CLH39_RS19565	COG1280	lysine exporter protein (LysE YggA)
CLH39_RS19570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLH39_RS19590	COG0583	DNA-binding transcription factor activity
CLH39_RS19595	COG1335	isochorismatase
CLH39_RS19600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLH39_RS19610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLH39_RS19610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLH39_RS19615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLH39_RS19620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_RS19625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLH39_RS19630	COG0066	3-isopropylmalate dehydratase activity
CLH39_RS19635	COG4774	siderophore transport
CLH39_RS19640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLH39_RS19655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLH39_RS19690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLH39_RS19710	COG1960	acyl-CoA dehydrogenase activity
CLH39_RS19715	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CLH39_RS19720	COG0183	Belongs to the thiolase family
CLH39_RS19725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta