locus-tag	class	description
TT65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TT65_RS00040	COG0751	glycine-tRNA ligase activity
TT65_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
TT65_RS00050	COG2818	Glycosylase
TT65_RS00070	COG1160	GTP binding
TT65_RS00075	COG1846	Transcriptional regulator
TT65_RS00090	COG1566	PFAM secretion protein HlyD family protein
TT65_RS00110	COG1960	acyl-CoA dehydrogenase activity
TT65_RS00120	COG5285	phytanoyl-CoA dioxygenase
TT65_RS00135	COG0435	Glutathione S-transferase
TT65_RS00140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TT65_RS00145	COG0583	DNA-binding transcription factor activity
TT65_RS00165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TT65_RS00180	COG0540	Belongs to the ATCase OTCase family
TT65_RS00185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TT65_RS00190	COG3038	cytochrome b561
TT65_RS00195	COG2353	YceI-like domain
TT65_RS00225	COG0678	peroxiredoxin activity
TT65_RS00245	COG1666	GTP binding
TT65_RS00260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT65_RS00260	COG0519	Catalyzes the synthesis of GMP from XMP
TT65_RS00270	COG0110	maltose O-acetyltransferase activity
TT65_RS00290	COG4399	Belongs to the UPF0754 family
TT65_RS00310	COG0604	alcohol dehydrogenase
TT65_RS00310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TT65_RS00310	COG4221	oxidoreductase activity
TT65_RS00310	COG3321	synthase
TT65_RS00320	COG1944	ATP diphosphatase activity
TT65_RS00325	COG2703	oxygen carrier activity
TT65_RS00335	COG0179	Fumarylacetoacetate (FAA) hydrolase
TT65_RS00340	COG0277	FAD linked oxidase domain protein
TT65_RS00345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TT65_RS00380	COG0475	glutathione-regulated potassium exporter activity
TT65_RS00380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TT65_RS00385	COG4773	Receptor
TT65_RS00395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TT65_RS00405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TT65_RS00425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TT65_RS00440	COG1309	transcriptional regulator
TT65_RS00445	COG0429	hydrolase of the alpha beta-hydrolase fold
TT65_RS00450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TT65_RS00480	COG0330	HflC and HflK could
TT65_RS00495	COG3038	cytochrome b561
TT65_RS00515	COG2201	protein-glutamate methylesterase activity
TT65_RS00530	COG0840	transmembrane signaling receptor activity
TT65_RS00550	COG0189	ligase activity
TT65_RS00560	COG1678	Uncharacterized ACR, COG1678
TT65_RS00565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TT65_RS00585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TT65_RS00590	COG0583	DNA-binding transcription factor activity
TT65_RS00610	COG3239	Fatty acid desaturase
TT65_RS00620	COG3121	Chaperone
TT65_RS00625	COG3188	usher protein
TT65_RS00635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TT65_RS00640	COG0569	domain protein
TT65_RS00645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TT65_RS00650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TT65_RS00655	COG0242	peptide deformylase activity
TT65_RS00665	COG0758	DNA mediated transformation
TT65_RS00670	COG0009	L-threonylcarbamoyladenylate synthase
TT65_RS00675	COG0408	coproporphyrinogen oxidase activity
TT65_RS00680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TT65_RS00695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TT65_RS00705	COG0339	signal peptide processing
TT65_RS00735	COG0583	DNA-binding transcription factor activity
TT65_RS00740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TT65_RS00745	COG1024	Enoyl-CoA hydratase
TT65_RS00745	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT65_RS00765	COG1278	Cold shock
TT65_RS00780	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TT65_RS00785	COG1121	(ABC) transporter
TT65_RS00790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TT65_RS00795	COG0534	Mate efflux family protein
TT65_RS00800	COG2199	diguanylate cyclase activity
TT65_RS00815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT65_RS00820	COG1773	rubredoxin
TT65_RS00825	COG3161	chorismate lyase activity
TT65_RS00830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TT65_RS00845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TT65_RS00850	COG0583	DNA-binding transcription factor activity
TT65_RS00860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TT65_RS00865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TT65_RS00885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TT65_RS00890	COG1758	RNA polymerase activity
TT65_RS00895	COG0194	GDP metabolic process
TT65_RS00900	COG3608	succinylglutamate desuccinylase aspartoacylase
TT65_RS00905	COG0129	dihydroxy-acid dehydratase activity
TT65_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
TT65_RS00930	COG1960	acyl-CoA dehydrogenase activity
TT65_RS00995	COG1309	transcriptional regulator
TT65_RS01005	COG0633	Ferredoxin
TT65_RS01030	COG1561	YicC-like family, N-terminal region
TT65_RS01035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TT65_RS01040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TT65_RS01050	COG1309	transcriptional regulator
TT65_RS01055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT65_RS01065	COG0756	dUTP diphosphatase activity
TT65_RS01070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TT65_RS01075	COG2003	Belongs to the UPF0758 family
TT65_RS01080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TT65_RS01085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TT65_RS01105	COG4964	Belongs to the GSP D family
TT65_RS01180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TT65_RS01210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TT65_RS01240	COG0789	Transcriptional regulator
TT65_RS01250	COG3530	Putative quorum-sensing-regulated virulence factor
TT65_RS01260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TT65_RS01265	COG1136	(ABC) transporter
TT65_RS01265	COG0577	efflux transmembrane transporter activity
TT65_RS01270	COG1538	Outer membrane efflux protein
TT65_RS01275	COG0123	including yeast histone deacetylase and acetoin utilization protein
TT65_RS01285	COG0183	Belongs to the thiolase family
TT65_RS01290	COG0488	(ABC) transporter
TT65_RS01310	COG0545	Peptidyl-prolyl cis-trans isomerase
TT65_RS01320	COG1346	cytolysis
TT65_RS01330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TT65_RS01335	COG2918	glutathione biosynthetic process
TT65_RS01340	COG2183	response to ionizing radiation
TT65_RS01350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TT65_RS01355	COG1566	PFAM secretion protein HlyD family protein
TT65_RS01375	COG0569	domain protein
TT65_RS01380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TT65_RS01385	COG1295	ribonuclease BN
TT65_RS01390	COG1252	NADH dehydrogenase
TT65_RS01395	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TT65_RS01400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TT65_RS01405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TT65_RS01410	COG1011	Hydrolase
TT65_RS01415	COG0494	nUDIX hydrolase
TT65_RS01420	COG1218	3'(2'),5'-bisphosphate nucleotidase
TT65_RS01430	COG2072	flavoprotein involved in K transport
TT65_RS01475	COG0488	(ABC) transporter
TT65_RS01490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TT65_RS01500	COG0473	3-isopropylmalate dehydrogenase activity
TT65_RS01505	COG1131	(ABC) transporter
TT65_RS01510	COG0842	Transport permease protein
TT65_RS01515	COG3781	membrane
TT65_RS01520	COG3268	Saccharopine dehydrogenase
TT65_RS01530	COG0259	pyridoxamine-phosphate oxidase activity
TT65_RS01545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TT65_RS01550	COG0733	neurotransmitter:sodium symporter activity
TT65_RS01555	COG2914	Belongs to the UPF0125 (RnfH) family
TT65_RS01570	COG0497	DNA recombination
TT65_RS01580	COG1420	regulation of RNA biosynthetic process
TT65_RS01585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TT65_RS01590	COG0443	Heat shock 70 kDa protein
TT65_RS01595	COG0484	heat shock protein binding
TT65_RS01600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TT65_RS01605	COG0505	Belongs to the CarA family
TT65_RS01610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TT65_RS01625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TT65_RS01630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TT65_RS01635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TT65_RS01640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TT65_RS01645	COG0149	triose-phosphate isomerase activity
TT65_RS01665	COG0779	Required for maturation of 30S ribosomal subunits
TT65_RS01670	COG2251	uridine kinase activity
TT65_RS01670	COG0195	Participates in both transcription termination and antitermination
TT65_RS01675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TT65_RS01680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TT65_RS01690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TT65_RS01695	COG1185	polyribonucleotide nucleotidyltransferase activity
TT65_RS01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT65_RS01705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TT65_RS01710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TT65_RS01715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TT65_RS01720	COG1428	Deoxynucleoside kinase
TT65_RS01725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TT65_RS01740	COG3852	Histidine kinase
TT65_RS01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT65_RS01755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TT65_RS01765	COG0436	Aminotransferase
TT65_RS01770	COG1489	DNA binding
TT65_RS01775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TT65_RS01785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TT65_RS01790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TT65_RS01805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TT65_RS01810	COG0352	thiamine-phosphate diphosphorylase activity
TT65_RS01815	COG0351	phosphomethylpyrimidine kinase
TT65_RS01815	COG0352	thiamine-phosphate diphosphorylase activity
TT65_RS01815	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TT65_RS01820	COG1981	membrane
TT65_RS01830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TT65_RS01845	COG0316	Belongs to the HesB IscA family
TT65_RS01855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TT65_RS01860	COG0739	heme binding
TT65_RS01865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TT65_RS01905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TT65_RS01935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT65_RS01955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TT65_RS01960	COG0081	regulation of translation
TT65_RS01965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TT65_RS01970	COG0222	ribosome binding
TT65_RS01975	COG0085	RNA polymerase activity
TT65_RS01980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TT65_RS01985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TT65_RS01990	COG0049	tRNA binding
TT65_RS01995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TT65_RS02000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT65_RS02010	COG1215	transferase activity, transferring glycosyl groups
TT65_RS02015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TT65_RS02060	COG0662	Cupin 2, conserved barrel domain protein
TT65_RS02060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TT65_RS02065	COG0051	transcription antitermination factor activity, RNA binding
TT65_RS02070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TT65_RS02075	COG0088	Forms part of the polypeptide exit tunnel
TT65_RS02080	COG0089	rRNA binding
TT65_RS02085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TT65_RS02090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TT65_RS02095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TT65_RS02100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TT65_RS02105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TT65_RS02110	COG0255	Belongs to the universal ribosomal protein uL29 family
TT65_RS02115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TT65_RS02120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TT65_RS02125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TT65_RS02130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TT65_RS02135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TT65_RS02140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TT65_RS02145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TT65_RS02150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TT65_RS02155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TT65_RS02160	COG1841	ribosomal large subunit assembly
TT65_RS02165	COG0200	Binds to the 23S rRNA
TT65_RS02175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TT65_RS02180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TT65_RS02185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TT65_RS02190	COG0202	RNA polymerase activity
TT65_RS02195	COG0203	ribosomal protein L17
TT65_RS02225	COG2814	Major facilitator Superfamily
TT65_RS02240	COG3031	protein transport across the cell outer membrane
TT65_RS02260	COG2267	carboxylic ester hydrolase activity
TT65_RS02265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TT65_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TT65_RS02300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TT65_RS02340	COG0142	geranyltranstransferase activity
TT65_RS02345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TT65_RS02350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TT65_RS02355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TT65_RS02360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TT65_RS02365	COG0268	Binds directly to 16S ribosomal RNA
TT65_RS02370	COG0728	peptidoglycan biosynthetic process
TT65_RS02375	COG0196	riboflavin kinase activity
TT65_RS02380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TT65_RS02390	COG1047	Peptidyl-prolyl cis-trans
TT65_RS02395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TT65_RS02400	COG4969	Belongs to the N-Me-Phe pilin family
TT65_RS02490	COG0028	Belongs to the TPP enzyme family
TT65_RS02510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TT65_RS02515	COG1183	phosphatidylcholine synthase activity
TT65_RS02540	COG1597	lipid kinase activity
TT65_RS02560	COG0525	valine-tRNA ligase activity
TT65_RS02575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TT65_RS02580	COG0795	lipopolysaccharide-transporting ATPase activity
TT65_RS02585	COG0795	lipopolysaccharide-transporting ATPase activity
TT65_RS02600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TT65_RS02605	COG0343	queuine tRNA-ribosyltransferase activity
TT65_RS02610	COG1862	Preprotein translocase
TT65_RS02615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TT65_RS02630	COG0436	Aminotransferase
TT65_RS02635	COG0154	amidase activity
TT65_RS02650	COG0473	3-isopropylmalate dehydrogenase activity
TT65_RS02655	COG1012	belongs to the aldehyde dehydrogenase family
TT65_RS02665	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TT65_RS02675	COG0012	GTP binding
TT65_RS02680	COG0193	aminoacyl-tRNA hydrolase activity
TT65_RS02685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TT65_RS02690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TT65_RS02700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TT65_RS02705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TT65_RS02715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TT65_RS02720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TT65_RS02725	COG2890	protein-(glutamine-N5) methyltransferase activity
TT65_RS02740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT65_RS02745	COG0154	amidase activity
TT65_RS02750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT65_RS02755	COG1077	Cell shape determining protein MreB Mrl
TT65_RS02760	COG1792	Involved in formation and maintenance of cell shape
TT65_RS02765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TT65_RS02770	COG0424	maF-like protein
TT65_RS02780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT65_RS02785	COG0312	modulator of DNA gyrase
TT65_RS02800	COG3028	Belongs to the UPF0307 family
TT65_RS02805	COG0312	modulator of DNA gyrase
TT65_RS02810	COG2239	Acts as a magnesium transporter
TT65_RS02820	COG2181	nitrate reductase activity
TT65_RS02825	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TT65_RS02830	COG1140	nitrate reductase beta subunit
TT65_RS02835	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TT65_RS02840	COG2223	nitrite transmembrane transporter activity
TT65_RS02845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TT65_RS02850	COG1660	Displays ATPase and GTPase activities
TT65_RS02865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TT65_RS02870	COG1137	ATPase activity
TT65_RS02885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TT65_RS02905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TT65_RS02910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TT65_RS02915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TT65_RS02920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT65_RS02930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT65_RS02935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TT65_RS02940	COG1597	lipid kinase activity
TT65_RS02950	COG2945	thiolester hydrolase activity
TT65_RS02955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TT65_RS02960	COG1960	acyl-CoA dehydrogenase activity
TT65_RS02975	COG0667	Aldo Keto reductase
TT65_RS02980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TT65_RS02985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TT65_RS02990	COG0723	plastoquinol--plastocyanin reductase activity
TT65_RS02995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TT65_RS03000	COG2857	Cytochrome c1
TT65_RS03005	COG0625	glutathione transferase activity
TT65_RS03010	COG2969	positive regulation of protein catabolic process
TT65_RS03015	COG2823	Periplasmic or secreted lipoprotein
TT65_RS03025	COG0792	nuclease activity
TT65_RS03030	COG3107	peptidoglycan biosynthetic process
TT65_RS03040	COG0426	domain, Protein
TT65_RS03040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TT65_RS03045	COG2001	Belongs to the MraZ family
TT65_RS03050	COG0275	rRNA processing
TT65_RS03065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TT65_RS03070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TT65_RS03075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TT65_RS03080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TT65_RS03085	COG0772	Belongs to the SEDS family
TT65_RS03090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TT65_RS03095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TT65_RS03100	COG1181	Belongs to the D-alanine--D-alanine ligase family
TT65_RS03105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TT65_RS03120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TT65_RS03130	COG0739	heme binding
TT65_RS03135	COG0653	protein targeting
TT65_RS03145	COG0494	nUDIX hydrolase
TT65_RS03150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TT65_RS03155	COG0237	dephospho-CoA kinase activity
TT65_RS03160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TT65_RS03175	COG4969	Belongs to the N-Me-Phe pilin family
TT65_RS03190	COG1115	amino acid carrier protein
TT65_RS03215	COG0508	dehydrogenase complex catalyzes the overall conversion of
TT65_RS03225	COG0745	RESPONSE REGULATOR receiver
TT65_RS03230	COG2205	protein histidine kinase activity
TT65_RS03235	COG2096	Adenosyltransferase
TT65_RS03240	COG4206	TonB-dependent receptor
TT65_RS03245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TT65_RS03250	COG2211	Major facilitator Superfamily
TT65_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS03265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TT65_RS03270	COG0459	protein refolding
TT65_RS03285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT65_RS03310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TT65_RS03315	COG2315	Protein conserved in bacteria
TT65_RS03335	COG0183	Belongs to the thiolase family
TT65_RS03370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TT65_RS03375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TT65_RS03385	COG1611	Belongs to the LOG family
TT65_RS03395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TT65_RS03405	COG2226	methyltransferase
TT65_RS03410	COG1733	regulation of RNA biosynthetic process
TT65_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS03450	COG0633	Ferredoxin
TT65_RS03450	COG0543	2 iron, 2 sulfur cluster binding
TT65_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TT65_RS03500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TT65_RS03520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TT65_RS03530	COG0705	Rhomboid family
TT65_RS03575	COG1451	nucleotide metabolic process
TT65_RS03620	COG1012	belongs to the aldehyde dehydrogenase family
TT65_RS03645	COG0450	alkyl hydroperoxide reductase
TT65_RS03655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TT65_RS03665	COG0745	RESPONSE REGULATOR receiver
TT65_RS03670	COG2205	protein histidine kinase activity
TT65_RS03675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TT65_RS03690	COG3842	ATPase activity
TT65_RS03695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TT65_RS03700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TT65_RS03715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TT65_RS03720	COG0450	alkyl hydroperoxide reductase
TT65_RS03725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TT65_RS03730	COG0137	argininosuccinate synthase activity
TT65_RS03735	COG0346	lactoylglutathione lyase activity
TT65_RS03740	COG0189	ligase activity
TT65_RS03740	COG4067	protein conserved in archaea
TT65_RS03745	COG0189	ligase activity
TT65_RS03755	COG2046	Belongs to the sulfate adenylyltransferase family
TT65_RS03775	COG0513	Belongs to the DEAD box helicase family
TT65_RS03790	COG1192	Involved in chromosome partitioning
TT65_RS03800	COG0442	prolyl-tRNA aminoacylation
TT65_RS03815	COG0729	surface antigen
TT65_RS03820	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TT65_RS03830	COG2226	methyltransferase
TT65_RS03850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TT65_RS03855	COG0217	transcriptional regulatory protein
TT65_RS03860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TT65_RS03865	COG0632	four-way junction helicase activity
TT65_RS03870	COG2255	four-way junction helicase activity
TT65_RS03875	COG0824	Thioesterase
TT65_RS03895	COG0823	Involved in the tonB-independent uptake of proteins
TT65_RS03910	COG0602	queuosine metabolic process
TT65_RS03915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TT65_RS03940	COG0789	Transcriptional regulator
TT65_RS04015	COG2801	Transposase and inactivated derivatives
TT65_RS04035	COG0789	Transcriptional regulator
TT65_RS04040	COG0415	Belongs to the DNA photolyase family
TT65_RS04055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TT65_RS04060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TT65_RS04065	COG4783	chaperone-mediated protein folding
TT65_RS04070	COG0425	Belongs to the sulfur carrier protein TusA family
TT65_RS04080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TT65_RS04085	COG2716	regulation of RNA biosynthetic process
TT65_RS04090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TT65_RS04100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TT65_RS04105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TT65_RS04135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TT65_RS04140	COG0047	phosphoribosylformylglycinamidine synthase activity
TT65_RS04140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TT65_RS04150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TT65_RS04155	COG2816	NAD+ diphosphatase activity
TT65_RS04160	COG2197	response regulator
TT65_RS04170	COG0494	nUDIX hydrolase
TT65_RS04185	COG1752	Esterase of the alpha-beta hydrolase superfamily
TT65_RS04190	COG4536	flavin adenine dinucleotide binding
TT65_RS04200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TT65_RS04205	COG0228	four-way junction DNA binding
TT65_RS04210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TT65_RS04215	COG0336	Belongs to the RNA methyltransferase TrmD family
TT65_RS04220	COG0335	large ribosomal subunit rRNA binding
TT65_RS04225	COG2261	transglycosylase associated protein
TT65_RS04235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TT65_RS04240	COG0436	Aminotransferase
TT65_RS04250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TT65_RS04255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TT65_RS04260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TT65_RS04275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TT65_RS04280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT65_RS04285	COG2264	protein methyltransferase activity
TT65_RS04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT65_RS04315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TT65_RS04330	COG5001	Diguanylate cyclase
TT65_RS04355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TT65_RS04360	COG0642	Histidine kinase
TT65_RS04375	COG4977	sequence-specific DNA binding
TT65_RS04380	COG1960	acyl-CoA dehydrogenase activity
TT65_RS04390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TT65_RS04400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TT65_RS04405	COG3088	subunit of a heme lyase
TT65_RS04405	COG4235	cytochrome complex assembly
TT65_RS04415	COG0563	adenylate kinase activity
TT65_RS04440	COG5016	pyruvate
TT65_RS04440	COG0511	ligase activity, forming carbon-carbon bonds
TT65_RS04470	COG0477	Major facilitator Superfamily
TT65_RS04480	COG1116	anion transmembrane transporter activity
TT65_RS04480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TT65_RS04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TT65_RS04490	COG1116	anion transmembrane transporter activity
TT65_RS04520	COG3707	response regulator
TT65_RS04525	COG1116	anion transmembrane transporter activity
TT65_RS04525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TT65_RS04530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TT65_RS04535	COG0583	DNA-binding transcription factor activity
TT65_RS04540	COG4807	Protein conserved in bacteria
TT65_RS04555	COG2954	triphosphatase activity
TT65_RS04570	COG4133	protoheme IX ABC transporter activity
TT65_RS04590	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TT65_RS04595	COG0189	ligase activity
TT65_RS04600	COG0625	glutathione transferase activity
TT65_RS04620	COG1131	(ABC) transporter
TT65_RS04625	COG0842	Transport permease protein
TT65_RS04630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TT65_RS04630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TT65_RS04635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TT65_RS04705	COG0778	Nitroreductase
TT65_RS04760	COG0438	transferase activity, transferring glycosyl groups
TT65_RS04770	COG2373	Large extracellular alpha-helical protein
TT65_RS04775	COG1943	Transposase
TT65_RS04780	COG4953	penicillin-binding protein 1C
TT65_RS04785	COG3383	formate dehydrogenase (NAD+) activity
TT65_RS04810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT65_RS04820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TT65_RS04830	COG1088	dTDP-glucose 4,6-dehydratase activity
TT65_RS04835	COG1091	dTDP-4-dehydrorhamnose reductase activity
TT65_RS04870	COG0438	transferase activity, transferring glycosyl groups
TT65_RS04880	COG0438	transferase activity, transferring glycosyl groups
TT65_RS04905	COG0438	transferase activity, transferring glycosyl groups
TT65_RS04910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TT65_RS04915	COG2755	lipolytic protein G-D-S-L family
TT65_RS04915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TT65_RS04925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TT65_RS04930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TT65_RS04930	COG2755	lipolytic protein G-D-S-L family
TT65_RS04945	COG3273	potassium ion transport
TT65_RS04945	COG0471	metal ion transport
TT65_RS04950	COG0529	Catalyzes the synthesis of activated sulfate
TT65_RS04955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TT65_RS04970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TT65_RS04980	COG0166	Belongs to the GPI family
TT65_RS04990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TT65_RS05005	COG1215	transferase activity, transferring glycosyl groups
TT65_RS05015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TT65_RS05025	COG0436	Aminotransferase
TT65_RS05045	COG3115	cell septum assembly
TT65_RS05050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TT65_RS05070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TT65_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS05090	COG1960	acyl-CoA dehydrogenase activity
TT65_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS05125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TT65_RS05135	COG1309	transcriptional regulator
TT65_RS05140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TT65_RS05145	COG3089	Belongs to the UPF0270 family
TT65_RS05150	COG3788	relative of glutathione S-transferase, MAPEG superfamily
TT65_RS05155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT65_RS05155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TT65_RS05165	COG5002	protein histidine kinase activity
TT65_RS05165	COG2205	protein histidine kinase activity
TT65_RS05165	COG0784	Response regulator, receiver
TT65_RS05175	COG4106	trans-aconitate 2-methyltransferase activity
TT65_RS05180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TT65_RS05225	COG0183	Belongs to the thiolase family
TT65_RS05230	COG1960	acyl-CoA dehydrogenase activity
TT65_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
TT65_RS05250	COG1960	acyl-CoA dehydrogenase activity
TT65_RS05255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT65_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS05270	COG1309	transcriptional regulator
TT65_RS05295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT65_RS05300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TT65_RS05310	COG2267	carboxylic ester hydrolase activity
TT65_RS05315	COG0308	aminopeptidase N
TT65_RS05345	COG3130	regulation of translation
TT65_RS05350	COG0116	Belongs to the methyltransferase superfamily
TT65_RS05350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TT65_RS05370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TT65_RS05380	COG0589	response to stress
TT65_RS05410	COG1376	ErfK ybiS ycfS ynhG family protein
TT65_RS05415	COG1472	Belongs to the glycosyl hydrolase 3 family
TT65_RS05420	COG0668	transmembrane transport
TT65_RS05425	COG0037	tRNA processing
TT65_RS05425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TT65_RS05435	COG1253	flavin adenine dinucleotide binding
TT65_RS05440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TT65_RS05445	COG2081	HI0933 family
TT65_RS05465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TT65_RS05470	COG1946	Acyl-CoA thioesterase
TT65_RS05475	COG1573	uracil-dna glycosylase
TT65_RS05485	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TT65_RS05490	COG1805	sodium ion transport
TT65_RS05505	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TT65_RS05510	COG2871	sodium ion transport
TT65_RS05515	COG1477	protein flavinylation
TT65_RS05535	COG0584	glycerophosphoryl diester phosphodiesterase
TT65_RS05545	COG0438	transferase activity, transferring glycosyl groups
TT65_RS05555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT65_RS05560	COG2957	Belongs to the agmatine deiminase family
TT65_RS05570	COG4591	ABC-type transport system involved in lipoprotein release permease component
TT65_RS05575	COG1136	(ABC) transporter
TT65_RS05590	COG0811	peptide transport
TT65_RS05595	COG0848	biopolymer transport protein
TT65_RS05600	COG1132	(ABC) transporter
TT65_RS05605	COG1663	tetraacyldisaccharide 4'-kinase activity
TT65_RS05610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TT65_RS05615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT65_RS05620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TT65_RS05625	COG1530	ribonuclease E activity
TT65_RS05635	COG0546	phosphoglycolate phosphatase activity
TT65_RS05640	COG0616	signal peptide processing
TT65_RS05640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TT65_RS05645	COG0424	maF-like protein
TT65_RS05650	COG1399	metal-binding, possibly nucleic acid-binding protein
TT65_RS05655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TT65_RS05660	COG0416	fatty acid biosynthetic process
TT65_RS05675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TT65_RS05680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TT65_RS05690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TT65_RS05695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TT65_RS05710	COG0084	hydrolase, TatD family'
TT65_RS05715	COG1322	Protein conserved in bacteria
TT65_RS05730	COG1104	cysteine desulfurase activity
TT65_RS05745	COG2815	serine threonine protein kinase
TT65_RS05745	COG0515	serine threonine protein kinase
TT65_RS05750	COG2223	nitrite transmembrane transporter activity
TT65_RS05755	COG2146	nitrite reductase [NAD(P)H] activity
TT65_RS05755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT65_RS05760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT65_RS05760	COG2146	nitrite reductase [NAD(P)H] activity
TT65_RS05765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT65_RS05770	COG0243	molybdopterin cofactor binding
TT65_RS05780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT65_RS05785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TT65_RS05800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT65_RS05800	COG3153	acetyltransferase
TT65_RS05820	COG0583	DNA-binding transcription factor activity
TT65_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS05860	COG2308	Evidence 4 Homologs of previously reported genes of
TT65_RS05870	COG1305	Transglutaminase-like
TT65_RS05880	COG2194	sulfuric ester hydrolase activity
TT65_RS05920	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TT65_RS05925	COG2894	cell division
TT65_RS05930	COG0850	regulation of cytokinetic process
TT65_RS05935	COG1960	acyl-CoA dehydrogenase activity
TT65_RS05940	COG3118	belongs to the thioredoxin family
TT65_RS05950	COG0004	ammonium transporteR
TT65_RS05960	COG0746	molybdenum cofactor guanylyltransferase activity
TT65_RS05965	COG1199	ATP-dependent helicase activity
TT65_RS05970	COG1214	PFAM Peptidase M22, glycoprotease
TT65_RS05980	COG1968	undecaprenyl-diphosphatase activity
TT65_RS05985	COG0742	ribosomal rna small subunit methyltransferase
TT65_RS05990	COG2937	Belongs to the GPAT DAPAT family
TT65_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
TT65_RS06010	COG1566	PFAM secretion protein HlyD family protein
TT65_RS06020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT65_RS06030	COG1393	Belongs to the ArsC family
TT65_RS06035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT65_RS06040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TT65_RS06050	COG0052	Belongs to the universal ribosomal protein uS2 family
TT65_RS06055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TT65_RS06060	COG0528	UMP kinase activity
TT65_RS06065	COG0233	cytoplasmic translational termination
TT65_RS06070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TT65_RS06075	COG0575	Belongs to the CDS family
TT65_RS06080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TT65_RS06100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TT65_RS06105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TT65_RS06110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TT65_RS06115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TT65_RS06120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TT65_RS06130	COG0825	malonyl-CoA metabolic process
TT65_RS06135	COG0037	tRNA processing
TT65_RS06140	COG0514	ATP-dependent DNA helicase (RecQ)
TT65_RS06145	COG0504	CTP synthase activity
TT65_RS06150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TT65_RS06155	COG0148	phosphopyruvate hydratase activity
TT65_RS06160	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TT65_RS06170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TT65_RS06175	COG0585	pseudouridine synthase activity
TT65_RS06180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TT65_RS06195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TT65_RS06210	COG1454	alcohol dehydrogenase
TT65_RS06215	COG0824	Thioesterase
TT65_RS06220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TT65_RS06230	COG0501	Belongs to the peptidase M48B family
TT65_RS06235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TT65_RS06245	COG0436	Aminotransferase
TT65_RS06255	COG0672	)-iron permease
TT65_RS06270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT65_RS06280	COG0316	Belongs to the HesB IscA family
TT65_RS06280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TT65_RS06290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TT65_RS06305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT65_RS06330	COG1881	PFAM PEBP family protein
TT65_RS06355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TT65_RS06360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TT65_RS06370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT65_RS06375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TT65_RS06395	COG0544	peptidyl-prolyl cis-trans isomerase activity
TT65_RS06400	COG0740	serine-type endopeptidase activity
TT65_RS06405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TT65_RS06410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT65_RS06425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TT65_RS06435	COG4172	Belongs to the ABC transporter superfamily
TT65_RS06440	COG4239	(ABC) transporter, permease
TT65_RS06445	COG4174	ABC transporter (Permease)
TT65_RS06450	COG4166	transmembrane transport
TT65_RS06455	COG4166	transmembrane transport
TT65_RS06460	COG0741	lytic transglycosylase activity
TT65_RS06460	COG1388	LysM domain
TT65_RS06465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT65_RS06475	COG0328	RNA-DNA hybrid ribonuclease activity
TT65_RS06485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TT65_RS06495	COG2816	NAD+ diphosphatase activity
TT65_RS06505	COG0616	signal peptide processing
TT65_RS06510	COG0604	alcohol dehydrogenase
TT65_RS06515	COG2084	Dehydrogenase
TT65_RS06520	COG3622	Belongs to the hyi family
TT65_RS06525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TT65_RS06535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT65_RS06550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT65_RS06555	COG1960	acyl-CoA dehydrogenase activity
TT65_RS06575	COG0702	epimerase
TT65_RS06580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TT65_RS06585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TT65_RS06585	COG0517	IMP dehydrogenase activity
TT65_RS06585	COG0617	tRNA 3'-terminal CCA addition
TT65_RS06595	COG0039	L-malate dehydrogenase activity
TT65_RS06615	COG0271	Belongs to the BolA IbaG family
TT65_RS06620	COG1054	Belongs to the UPF0176 family
TT65_RS06635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TT65_RS06670	COG1960	acyl-CoA dehydrogenase activity
TT65_RS06675	COG1960	acyl-CoA dehydrogenase activity
TT65_RS06680	COG0300	oxidoreductase activity
TT65_RS06685	COG0037	tRNA processing
TT65_RS06690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TT65_RS06700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TT65_RS06715	COG2850	peptidyl-arginine hydroxylation
TT65_RS06725	COG2915	High frequency lysogenization protein hflD homolog
TT65_RS06730	COG0482	sulfurtransferase activity
TT65_RS06740	COG0315	cyclic pyranopterin monophosphate synthase activity
TT65_RS06745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TT65_RS06750	COG0314	molybdopterin synthase activity
TT65_RS06770	COG1278	Cold shock
TT65_RS06780	COG0542	response to heat
TT65_RS06785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TT65_RS06790	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TT65_RS06795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TT65_RS06800	COG0492	ferredoxin-NADP+ reductase activity
TT65_RS06805	COG1674	ftsk spoiiie
TT65_RS06810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TT65_RS06815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TT65_RS06820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TT65_RS06825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TT65_RS06830	COG1648	precorrin-2 dehydrogenase activity
TT65_RS06830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT65_RS06835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TT65_RS06850	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TT65_RS06865	COG0003	Pfam Anion-transporting ATPase
TT65_RS06875	COG1966	Carbon starvation protein
TT65_RS06885	COG0322	excinuclease ABC activity
TT65_RS06910	COG5002	protein histidine kinase activity
TT65_RS06910	COG0784	Response regulator, receiver
TT65_RS06915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TT65_RS06965	COG3156	type II secretion system protein K
TT65_RS06975	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
TT65_RS07000	COG0668	transmembrane transport
TT65_RS07040	COG0700	Nucleoside recognition
TT65_RS07050	COG0598	Magnesium transport protein CorA
TT65_RS07065	COG3022	response to hydroperoxide
TT65_RS07075	COG0589	response to stress
TT65_RS07080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT65_RS07110	COG0348	domain, Protein
TT65_RS07115	COG2010	Cytochrome c
TT65_RS07130	COG3278	Belongs to the heme-copper respiratory oxidase family
TT65_RS07135	COG3321	synthase
TT65_RS07135	COG0604	alcohol dehydrogenase
TT65_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS07140	COG0583	DNA-binding transcription factor activity
TT65_RS07170	COG0542	response to heat
TT65_RS07185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TT65_RS07195	COG0180	Tryptophanyl-tRNA synthetase
TT65_RS07200	COG0009	L-threonylcarbamoyladenylate synthase
TT65_RS07205	COG0613	PHP domain protein
TT65_RS07210	COG2917	probably involved in intracellular septation
TT65_RS07215	COG2350	Protein conserved in bacteria
TT65_RS07230	COG0204	Acyl-transferase
TT65_RS07250	COG4181	ATPase activity
TT65_RS07255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TT65_RS07260	COG2814	Major facilitator Superfamily
TT65_RS07270	COG0789	Transcriptional regulator
TT65_RS07280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TT65_RS07285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TT65_RS07290	COG0277	FAD linked oxidase domain protein
TT65_RS07300	COG2885	chlorophyll binding
TT65_RS07305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TT65_RS07305	COG2169	Transcriptional regulator
TT65_RS07310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TT65_RS07340	COG3243	poly(R)-hydroxyalkanoic acid synthase
TT65_RS07355	COG3339	Conserved Protein
TT65_RS07360	COG1192	Involved in chromosome partitioning
TT65_RS07370	COG0069	glutamate synthase activity
TT65_RS07375	COG0741	lytic transglycosylase activity
TT65_RS07375	COG0739	heme binding
TT65_RS07375	COG1196	nuclear chromosome segregation
TT65_RS07390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TT65_RS07395	COG2079	MmgE PrpD family protein
TT65_RS07400	COG2828	Protein conserved in bacteria
TT65_RS07410	COG0372	Belongs to the citrate synthase family
TT65_RS07415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TT65_RS07420	COG1802	Transcriptional regulator
TT65_RS07430	COG0560	Phosphoserine phosphatase
TT65_RS07470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TT65_RS07475	COG0235	Class ii aldolase
TT65_RS07480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TT65_RS07485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TT65_RS07490	COG2813	Specifically methylates the guanine in position
TT65_RS07500	COG1643	Atp-dependent helicase
TT65_RS07520	COG0714	Associated with various cellular activities
TT65_RS07535	COG1286	toxin biosynthetic process
TT65_RS07545	COG0285	dihydrofolate synthase activity
TT65_RS07550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TT65_RS07555	COG0159	tryptophan synthase activity
TT65_RS07565	COG0135	phosphoribosylanthranilate isomerase activity
TT65_RS07570	COG0101	tRNA pseudouridine synthase activity
TT65_RS07580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TT65_RS07590	COG0473	3-isopropylmalate dehydrogenase activity
TT65_RS07600	COG0066	3-isopropylmalate dehydratase activity
TT65_RS07605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TT65_RS07620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TT65_RS07635	COG0004	ammonium transporteR
TT65_RS07645	COG1301	dicarboxylic acid transport
TT65_RS07655	COG4221	oxidoreductase activity
TT65_RS07685	COG0708	Exodeoxyribonuclease III
TT65_RS07695	COG2062	phosphohistidine phosphatase, SixA
TT65_RS07700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TT65_RS07705	COG0326	Molecular chaperone. Has ATPase activity
TT65_RS07720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TT65_RS07725	COG0045	succinate-CoA ligase (ADP-forming) activity
TT65_RS07745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TT65_RS07750	COG1053	succinate dehydrogenase
TT65_RS07755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TT65_RS07775	COG2084	Dehydrogenase
TT65_RS07815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT65_RS07825	COG0589	response to stress
TT65_RS07830	COG0659	secondary active sulfate transmembrane transporter activity
TT65_RS07840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TT65_RS07850	COG2853	Lipoprotein
TT65_RS07860	COG3220	belongs to the UPF0276 family
TT65_RS07875	COG1643	Atp-dependent helicase
TT65_RS07895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TT65_RS07915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TT65_RS07920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TT65_RS07985	COG1254	Belongs to the acylphosphatase family
TT65_RS07990	COG1295	ribonuclease BN
TT65_RS07990	COG1959	2 iron, 2 sulfur cluster binding
TT65_RS07995	COG1393	Belongs to the ArsC family
TT65_RS08030	COG0714	Associated with various cellular activities
TT65_RS08035	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
TT65_RS08040	COG3101	peptidyl-lysine hydroxylation
TT65_RS08080	COG2814	Major facilitator Superfamily
TT65_RS08085	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TT65_RS08090	COG0788	formyltetrahydrofolate deformylase activity
TT65_RS08105	COG1024	Enoyl-CoA hydratase
TT65_RS08105	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT65_RS08110	COG0183	Belongs to the thiolase family
TT65_RS08125	COG2840	Smr protein MutS2
TT65_RS08130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TT65_RS08135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TT65_RS08145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TT65_RS08150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TT65_RS08165	COG0717	Belongs to the dCTP deaminase family
TT65_RS08170	COG0489	protein tyrosine kinase activity
TT65_RS08215	COG2813	Specifically methylates the guanine in position
TT65_RS08220	COG0741	lytic transglycosylase activity
TT65_RS08225	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TT65_RS08245	COG1309	transcriptional regulator
TT65_RS08275	COG5002	protein histidine kinase activity
TT65_RS08275	COG0784	Response regulator, receiver
TT65_RS08275	COG2205	protein histidine kinase activity
TT65_RS08280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT65_RS08280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT65_RS08285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT65_RS08330	COG4657	Part of a membrane complex involved in electron transport
TT65_RS08335	COG2878	Part of a membrane complex involved in electron transport
TT65_RS08345	COG4658	electron transport chain
TT65_RS08350	COG4659	FMN binding
TT65_RS08355	COG4660	Part of a membrane complex involved in electron transport
TT65_RS08365	COG0786	glutamate:sodium symporter activity
TT65_RS08370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TT65_RS08380	COG1739	Uncharacterized protein family UPF0029
TT65_RS08395	COG3956	TIGRFAM MazG family protein
TT65_RS08400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TT65_RS08405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TT65_RS08420	COG2205	protein histidine kinase activity
TT65_RS08420	COG5002	protein histidine kinase activity
TT65_RS08420	COG0784	Response regulator, receiver
TT65_RS08425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TT65_RS08435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TT65_RS08440	COG0571	ribonuclease III activity
TT65_RS08455	COG0481	GTPase activity
TT65_RS08460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT65_RS08510	COG1024	Enoyl-CoA hydratase
TT65_RS08510	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT65_RS08515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TT65_RS08520	COG3226	Transcriptional regulator
TT65_RS08525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TT65_RS08540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TT65_RS08545	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT65_RS08545	COG1024	Enoyl-CoA hydratase
TT65_RS08550	COG0183	Belongs to the thiolase family
TT65_RS08590	COG0789	Transcriptional regulator
TT65_RS08595	COG0484	heat shock protein binding
TT65_RS08600	COG0318	PFAM AMP-dependent synthetase and ligase
TT65_RS08610	COG0210	DNA helicase
TT65_RS08650	COG1136	(ABC) transporter
TT65_RS08650	COG0577	efflux transmembrane transporter activity
TT65_RS08665	COG0735	belongs to the Fur family
TT65_RS08695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TT65_RS08700	COG0546	phosphoglycolate phosphatase activity
TT65_RS08710	COG0175	sulfate reduction
TT65_RS08720	COG4771	TonB-dependent receptor
TT65_RS08755	COG0513	Belongs to the DEAD box helicase family
TT65_RS08760	COG3360	Dodecin
TT65_RS08765	COG0778	Nitroreductase
TT65_RS08785	COG1960	acyl-CoA dehydrogenase activity
TT65_RS08790	COG1960	acyl-CoA dehydrogenase activity
TT65_RS08805	COG1902	pentaerythritol trinitrate reductase activity
TT65_RS08805	COG0446	pyridine nucleotide-disulphide oxidoreductase
TT65_RS08840	COG0183	Belongs to the thiolase family
TT65_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS08870	COG1309	transcriptional regulator
TT65_RS08875	COG2030	dehydratase
TT65_RS08880	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TT65_RS08885	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TT65_RS08890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TT65_RS08890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TT65_RS08895	COG3639	organic phosphonate transmembrane transporter activity
TT65_RS08905	COG0709	Synthesizes selenophosphate from selenide and ATP
TT65_RS08920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TT65_RS08925	COG3264	Mechanosensitive ion channel
TT65_RS08925	COG1196	nuclear chromosome segregation
TT65_RS08950	COG1901	pseudouridine methyltransferase
TT65_RS08965	COG0488	(ABC) transporter
TT65_RS08980	COG0284	orotidine-5'-phosphate decarboxylase activity
TT65_RS08995	COG0776	regulation of translation
TT65_RS09005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TT65_RS09010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TT65_RS09015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT65_RS09020	COG0077	Prephenate dehydratase
TT65_RS09020	COG1605	Chorismate mutase
TT65_RS09025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TT65_RS09035	COG0402	S-adenosylhomocysteine deaminase activity
TT65_RS09040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TT65_RS09045	COG0546	phosphoglycolate phosphatase activity
TT65_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS09105	COG2983	Belongs to the UPF0260 family
TT65_RS09110	COG3100	YcgL domain-containing protein
TT65_RS09115	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TT65_RS09120	COG0588	phosphoglycerate mutase activity
TT65_RS09130	COG1960	acyl-CoA dehydrogenase activity
TT65_RS09135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TT65_RS09140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TT65_RS09170	COG1695	Transcriptional regulator
TT65_RS09190	COG1819	glycosyl
TT65_RS09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TT65_RS09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TT65_RS09205	COG2801	Transposase and inactivated derivatives
TT65_RS09225	COG0427	acetyl-CoA hydrolase
TT65_RS09235	COG0523	cobalamin synthesis protein
TT65_RS09240	COG0418	dihydroorotase activity
TT65_RS09250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TT65_RS09255	COG0527	aspartate kinase activity
TT65_RS09260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TT65_RS09265	COG0730	response to heat
TT65_RS09270	COG2137	regulation of response to DNA damage stimulus
TT65_RS09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TT65_RS09280	COG1546	Belongs to the CinA family
TT65_RS09285	COG0217	transcriptional regulatory protein
TT65_RS09300	COG1021	2,3-dihydroxybenzoate-AMP ligase
TT65_RS09330	COG2963	transposase activity
TT65_RS09335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TT65_RS09340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TT65_RS09370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TT65_RS09375	COG1509	lysine 2,3-aminomutase activity
TT65_RS09380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TT65_RS09385	COG1074	ATP-dependent DNA helicase activity
TT65_RS09390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TT65_RS09400	COG3784	Protein of unknown function (DUF1318)
TT65_RS09415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TT65_RS09425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TT65_RS09440	COG0732	type I restriction modification DNA specificity domain
TT65_RS09445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TT65_RS09455	COG0537	adenosine 5'-monophosphoramidase activity
TT65_RS09470	COG0776	regulation of translation
TT65_RS09475	COG0072	phenylalanine-tRNA ligase activity
TT65_RS09480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TT65_RS09485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TT65_RS09490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TT65_RS09495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TT65_RS09505	COG0492	ferredoxin-NADP+ reductase activity
TT65_RS09520	COG0842	Transport permease protein
TT65_RS09525	COG0842	Transport permease protein
TT65_RS09525	COG1129	ABC transporter
TT65_RS09530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TT65_RS09535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT65_RS09535	COG0519	Catalyzes the synthesis of GMP from XMP
TT65_RS09540	COG3706	GGDEF domain
TT65_RS09540	COG5001	Diguanylate cyclase
TT65_RS09540	COG4251	negative regulation of phosphorylation
TT65_RS09540	COG2203	Gaf domain
TT65_RS09550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TT65_RS09555	COG2814	Major facilitator Superfamily
TT65_RS09565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT65_RS09565	COG0519	Catalyzes the synthesis of GMP from XMP
TT65_RS09575	COG1570	exodeoxyribonuclease VII activity
TT65_RS09595	COG1160	GTP binding
TT65_RS09600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TT65_RS09610	COG0124	histidyl-tRNA synthetase
TT65_RS09615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TT65_RS09620	COG1426	Protein conserved in bacteria
TT65_RS09630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TT65_RS09635	COG0105	UTP biosynthetic process
TT65_RS09640	COG0719	Fe-S assembly protein
TT65_RS09645	COG0396	ATPase activity
TT65_RS09650	COG0719	Fe-S assembly protein
TT65_RS09655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TT65_RS09660	COG0316	Belongs to the HesB IscA family
TT65_RS09670	COG2166	iron-sulfur cluster assembly
TT65_RS09675	COG1104	cysteine desulfurase activity
TT65_RS09695	COG4974	Belongs to the 'phage' integrase family
TT65_RS09705	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TT65_RS09710	COG1704	LemA family
TT65_RS09715	COG2827	Endonuclease containing a URI domain
TT65_RS09750	COG3842	ATPase activity
TT65_RS09760	COG3665	Urea carboxylase-associated protein
TT65_RS09765	COG0439	Biotin carboxylase
TT65_RS09775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TT65_RS09800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT65_RS09805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TT65_RS09830	COG1612	heme a metabolic process
TT65_RS09835	COG0109	protoheme IX farnesyltransferase activity
TT65_RS09845	COG1704	LemA family
TT65_RS09850	COG0501	Belongs to the peptidase M48B family
TT65_RS09865	COG1278	Cold shock
TT65_RS09870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TT65_RS09910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT65_RS09915	COG3047	cAMP biosynthetic process
TT65_RS09925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TT65_RS09965	COG1999	signal sequence binding
TT65_RS09970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT65_RS09975	COG1702	phosphate starvation-inducible protein PhoH
TT65_RS09980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TT65_RS09985	COG4535	Mg2 and Co2 transporter CorC
TT65_RS10000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TT65_RS10030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TT65_RS10035	COG0495	leucyl-tRNA aminoacylation
TT65_RS10055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TT65_RS10070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TT65_RS10075	COG0768	penicillin binding
TT65_RS10080	COG0772	Belongs to the SEDS family
TT65_RS10085	COG2951	lytic endotransglycosylase activity
TT65_RS10095	COG1686	Belongs to the peptidase S11 family
TT65_RS10105	COG2921	Belongs to the UPF0250 family
TT65_RS10115	COG0321	lipoyl(octanoyl) transferase activity
TT65_RS10120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TT65_RS10130	COG3015	lipoprotein NlpE involved in copper resistance
TT65_RS10135	COG0811	peptide transport
TT65_RS10160	COG0163	prenyltransferase activity
TT65_RS10170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TT65_RS10175	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TT65_RS10215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT65_RS10225	COG1131	(ABC) transporter
TT65_RS10240	COG0683	leucine binding
TT65_RS10245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TT65_RS10245	COG2198	Histidine kinase
TT65_RS10245	COG2205	protein histidine kinase activity
TT65_RS10245	COG0784	Response regulator, receiver
TT65_RS10250	COG0745	RESPONSE REGULATOR receiver
TT65_RS10260	COG0205	6-phosphofructokinase activity
TT65_RS10265	COG2233	PERMEase
TT65_RS10270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TT65_RS10280	COG1054	Belongs to the UPF0176 family
TT65_RS10285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TT65_RS10300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TT65_RS10305	COG3642	lipopolysaccharide core region biosynthetic process
TT65_RS10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TT65_RS10350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TT65_RS10355	COG0511	ligase activity, forming carbon-carbon bonds
TT65_RS10365	COG2264	protein methyltransferase activity
TT65_RS10385	COG0138	bifunctional purine biosynthesis protein purh
TT65_RS10390	COG0151	Belongs to the GarS family
TT65_RS10400	COG2205	protein histidine kinase activity
TT65_RS10400	COG3437	response regulator, receiver
TT65_RS10400	COG4999	Histidine kinase
TT65_RS10400	COG3850	Histidine kinase
TT65_RS10405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TT65_RS10410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TT65_RS10415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TT65_RS10420	COG1765	OsmC-like protein
TT65_RS10430	COG0134	indole-3-glycerol-phosphate synthase activity
TT65_RS10435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TT65_RS10440	COG0512	Glutamine amidotransferase of anthranilate synthase
TT65_RS10465	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TT65_RS10480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TT65_RS10485	COG1845	cytochrome c oxidase, subunit III
TT65_RS10490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT65_RS10495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TT65_RS10500	COG0477	Major facilitator Superfamily
TT65_RS10515	COG0791	NLP P60 protein
TT65_RS10520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TT65_RS10535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TT65_RS10540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TT65_RS10545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TT65_RS10550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TT65_RS10555	COG2967	ApaG domain
TT65_RS10570	COG0617	tRNA 3'-terminal CCA addition
TT65_RS10590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TT65_RS10590	COG0302	gtp cyclohydrolase
TT65_RS10595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TT65_RS10600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT65_RS10605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TT65_RS10610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TT65_RS10615	COG1610	YqeY-like protein
TT65_RS10625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TT65_RS10635	COG2801	Transposase and inactivated derivatives
TT65_RS10640	COG2963	transposase activity
TT65_RS10650	COG0443	Heat shock 70 kDa protein
TT65_RS10660	COG0513	Belongs to the DEAD box helicase family
TT65_RS10685	COG4774	siderophore transport
TT65_RS10705	COG4615	Cyclic peptide transporter
TT65_RS10720	COG1960	acyl-CoA dehydrogenase activity
TT65_RS10730	COG2832	Protein of unknown function (DUF454)
TT65_RS10735	COG1960	acyl-CoA dehydrogenase activity
TT65_RS10740	COG2835	tetraacyldisaccharide 4'-kinase activity
TT65_RS10770	COG4221	oxidoreductase activity
TT65_RS10785	COG0300	oxidoreductase activity
TT65_RS10800	COG0537	adenosine 5'-monophosphoramidase activity
TT65_RS10820	COG5001	Diguanylate cyclase
TT65_RS10820	COG4251	negative regulation of phosphorylation
TT65_RS10820	COG3706	GGDEF domain
TT65_RS10820	COG2203	Gaf domain
TT65_RS10825	COG1017	nitric oxide dioxygenase activity
TT65_RS10825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TT65_RS10830	COG1959	2 iron, 2 sulfur cluster binding
TT65_RS10845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TT65_RS10870	COG2070	2-Nitropropane dioxygenase
TT65_RS10885	COG3437	response regulator, receiver
TT65_RS10895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TT65_RS10900	COG0215	cysteine-tRNA ligase activity
TT65_RS10915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TT65_RS10945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TT65_RS10955	COG1469	GTP cyclohydrolase I activity
TT65_RS10965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TT65_RS10970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TT65_RS10975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TT65_RS10995	COG0662	Cupin 2, conserved barrel domain protein
TT65_RS11010	COG0784	Response regulator, receiver
TT65_RS11010	COG2205	protein histidine kinase activity
TT65_RS11030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TT65_RS11055	COG1722	exodeoxyribonuclease VII activity
TT65_RS11060	COG0142	geranyltranstransferase activity
TT65_RS11065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TT65_RS11070	COG5001	Diguanylate cyclase
TT65_RS11070	COG3706	GGDEF domain
TT65_RS11070	COG2203	Gaf domain
TT65_RS11070	COG4251	negative regulation of phosphorylation
TT65_RS11075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TT65_RS11080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TT65_RS11085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TT65_RS11090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TT65_RS11105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT65_RS11105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT65_RS11110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TT65_RS11115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TT65_RS11120	COG0488	(ABC) transporter
TT65_RS11130	COG1595	DNA-templated transcription, initiation
TT65_RS11145	COG2226	methyltransferase
TT65_RS11150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TT65_RS11165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TT65_RS11170	COG0305	Participates in initiation and elongation during chromosome replication
TT65_RS11175	COG0359	binds to the 23S rRNA
TT65_RS11180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TT65_RS11190	COG0360	Binds together with S18 to 16S ribosomal RNA
TT65_RS11195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT65_RS11200	COG0557	exoribonuclease II activity
TT65_RS11225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TT65_RS11230	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TT65_RS11240	COG0330	HflC and HflK could
TT65_RS11245	COG0330	HflC and HflK could
TT65_RS11250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TT65_RS11255	COG1923	regulation of RNA biosynthetic process
TT65_RS11260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TT65_RS11265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TT65_RS11270	COG0860	N-Acetylmuramoyl-L-alanine amidase
TT65_RS11275	COG0802	atpase or kinase
TT65_RS11280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TT65_RS11280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TT65_RS11290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TT65_RS11295	COG1162	GTPase activity
TT65_RS11305	COG0688	phosphatidylethanolamine metabolic process
TT65_RS11320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TT65_RS11325	COG2226	methyltransferase
TT65_RS11330	COG2267	carboxylic ester hydrolase activity
TT65_RS11335	COG0156	8-amino-7-oxononanoate synthase activity
TT65_RS11340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TT65_RS11345	COG1040	competence protein
TT65_RS11365	COG2154	pterin-4-alpha-carbinolamine dehydratase
TT65_RS11375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TT65_RS11380	COG0493	'glutamate synthase
TT65_RS11385	COG0070	glutamate synthase
TT65_RS11385	COG0069	glutamate synthase activity
TT65_RS11385	COG0067	glutamate synthase
TT65_RS11395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TT65_RS11400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TT65_RS11435	COG0281	malic enzyme
TT65_RS11440	COG0254	rRNA binding
TT65_RS11445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TT65_RS11450	COG0018	arginyl-trna synthetase
TT65_RS11460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TT65_RS11465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TT65_RS11475	COG2226	methyltransferase
TT65_RS11485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TT65_RS11490	COG0140	phosphoribosyl-ATP diphosphatase activity
TT65_RS11495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TT65_RS11500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TT65_RS11525	COG1490	D-aminoacyl-tRNA deacylase activity
TT65_RS11535	COG2204	response regulator
TT65_RS11540	COG3852	Histidine kinase
TT65_RS11560	COG0482	sulfurtransferase activity
TT65_RS11565	COG3083	sulfuric ester hydrolase activity
TT65_RS11585	COG1217	gtp-binding protein TYPA
TT65_RS11595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TT65_RS11600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TT65_RS11610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT65_RS11615	COG4942	peptidase
TT65_RS11620	COG0793	Belongs to the peptidase S41A family
TT65_RS11625	COG2861	carbohydrate metabolic process
TT65_RS11630	COG0107	imidazoleglycerol-phosphate synthase activity
TT65_RS11635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TT65_RS11645	COG0131	Imidazoleglycerol-phosphate dehydratase
TT65_RS11655	COG2205	protein histidine kinase activity
TT65_RS11665	COG1194	a g-specific adenine glycosylase
TT65_RS11670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TT65_RS11715	COG0582	viral genome integration into host DNA
TT65_RS11725	COG0501	Belongs to the peptidase M48B family
TT65_RS11730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TT65_RS11730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TT65_RS11740	COG1560	Kdo2-lipid A biosynthetic process
TT65_RS11755	COG1215	transferase activity, transferring glycosyl groups
TT65_RS11765	COG0438	transferase activity, transferring glycosyl groups
TT65_RS11780	COG0859	PFAM glycosyl transferase family 9
TT65_RS11795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TT65_RS11800	COG1392	Phosphate transport regulator
TT65_RS11805	COG0306	phosphate transporter
TT65_RS11810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT65_RS11810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TT65_RS11855	COG2995	paraquat-inducible protein a
TT65_RS11860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TT65_RS11860	COG3008	intermembrane lipid transfer
TT65_RS11875	COG2959	enzyme of heme biosynthesis
TT65_RS11885	COG0181	hydroxymethylbilane synthase activity
TT65_RS11895	COG3275	phosphorelay sensor kinase activity
TT65_RS11900	COG0165	Argininosuccinate lyase
TT65_RS11905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TT65_RS11915	COG0019	diaminopimelate decarboxylase activity
TT65_RS11920	COG1757	Na H antiporter
TT65_RS11930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TT65_RS11935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TT65_RS11945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TT65_RS11955	COG3098	single-species biofilm formation
TT65_RS11990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TT65_RS12000	COG0730	response to heat
TT65_RS12015	COG0494	nUDIX hydrolase
TT65_RS12040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TT65_RS12065	COG2132	Multicopper oxidase
TT65_RS12075	COG0288	reversible hydration of carbon dioxide
TT65_RS12080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TT65_RS12085	COG1047	Peptidyl-prolyl cis-trans
TT65_RS12090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TT65_RS12095	COG1492	cobalamin metabolic process
TT65_RS12110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TT65_RS12115	COG4139	cobalamin transport
TT65_RS12125	COG4206	TonB-dependent receptor
TT65_RS12135	COG1858	cytochrome C peroxidase
TT65_RS12150	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TT65_RS12155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TT65_RS12170	COG2824	Alkylphosphonate utilization operon protein PhnA
TT65_RS12180	COG0521	Mo-molybdopterin cofactor biosynthetic process
TT65_RS12190	COG0668	transmembrane transport
TT65_RS12195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT65_RS12215	COG0432	Pfam Uncharacterised protein family UPF0047
TT65_RS12220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TT65_RS12230	COG2072	flavoprotein involved in K transport
TT65_RS12250	COG1166	arginine decarboxylase activity
TT65_RS12270	COG0583	DNA-binding transcription factor activity
TT65_RS12285	COG3008	intermembrane lipid transfer
TT65_RS12290	COG2995	paraquat-inducible protein a
TT65_RS12300	COG0513	Belongs to the DEAD box helicase family
TT65_RS12315	COG0189	ligase activity
TT65_RS12315	COG4067	protein conserved in archaea
TT65_RS12320	COG2974	May be involved in recombination
TT65_RS12325	COG0656	L-ascorbic acid biosynthetic process
TT65_RS12330	COG0596	Alpha beta hydrolase
TT65_RS12335	COG4628	conserved protein (DUF2132)
TT65_RS12345	COG1309	transcriptional regulator
TT65_RS12350	COG1979	alcohol dehydrogenase
TT65_RS12360	COG1294	oxidase, subunit
TT65_RS12365	COG1271	oxidase subunit
TT65_RS12375	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TT65_RS12380	COG0625	glutathione transferase activity
TT65_RS12390	COG0583	DNA-binding transcription factor activity
TT65_RS12415	COG0450	alkyl hydroperoxide reductase
TT65_RS12425	COG3447	MASE1 domain protein
TT65_RS12425	COG5002	protein histidine kinase activity
TT65_RS12425	COG5001	Diguanylate cyclase
TT65_RS12430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TT65_RS12445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT65_RS12460	COG1024	Enoyl-CoA hydratase
TT65_RS12470	COG0560	Phosphoserine phosphatase
TT65_RS12470	COG3830	Belongs to the UPF0237 family
TT65_RS12475	COG3706	GGDEF domain
TT65_RS12485	COG1509	lysine 2,3-aminomutase activity
TT65_RS12490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TT65_RS12495	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TT65_RS12505	COG0596	Alpha beta hydrolase
TT65_RS12515	COG0183	Belongs to the thiolase family
TT65_RS12520	COG1960	acyl-CoA dehydrogenase activity
TT65_RS12540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TT65_RS12580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TT65_RS12605	COG4771	TonB-dependent receptor
TT65_RS12610	COG0154	amidase activity
TT65_RS12615	COG0604	alcohol dehydrogenase
TT65_RS12640	COG3122	Protein conserved in bacteria
TT65_RS12655	COG0204	Acyl-transferase
TT65_RS12670	COG3150	esterase
TT65_RS12675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TT65_RS12680	COG3151	Protein conserved in bacteria
TT65_RS12685	COG0494	nUDIX hydrolase
TT65_RS12690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TT65_RS12695	COG1538	Outer membrane efflux protein
TT65_RS12700	COG1519	Transferase
TT65_RS12710	COG0667	Aldo Keto reductase
TT65_RS12780	COG2205	protein histidine kinase activity
TT65_RS12780	COG0784	Response regulator, receiver
TT65_RS12790	COG4566	intracellular signal transduction
TT65_RS12795	COG4191	Histidine kinase
TT65_RS12810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TT65_RS12840	COG0004	ammonium transporteR
TT65_RS12845	COG0347	Belongs to the P(II) protein family
TT65_RS12850	COG2960	long-chain fatty acid transporting porin activity
TT65_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
TT65_RS12880	COG1187	pseudouridine synthase activity
TT65_RS12885	COG0210	DNA helicase
TT65_RS12915	COG2076	Multidrug Resistance protein
TT65_RS12980	COG1024	Enoyl-CoA hydratase
TT65_RS12995	COG1196	nuclear chromosome segregation
TT65_RS12995	COG3264	Mechanosensitive ion channel
TT65_RS13020	COG0742	ribosomal rna small subunit methyltransferase
TT65_RS13030	COG0612	Peptidase, M16
TT65_RS13035	COG0552	protein localization to endoplasmic reticulum
TT65_RS13040	COG2884	Cell division ATP-binding protein ftsE
TT65_RS13045	COG2177	Part of the ABC transporter FtsEX involved in
TT65_RS13055	COG2363	Small membrane protein
TT65_RS13065	COG2022	thiamine diphosphate biosynthetic process
TT65_RS13070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TT65_RS13085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TT65_RS13090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TT65_RS13090	COG2813	Specifically methylates the guanine in position
TT65_RS13100	COG1671	Belongs to the UPF0178 family
TT65_RS13105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TT65_RS13110	COG1309	transcriptional regulator
TT65_RS13120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TT65_RS13145	COG1280	lysine exporter protein (LysE YggA)
TT65_RS13160	COG2801	Transposase and inactivated derivatives
TT65_RS13190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT65_RS13195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT65_RS13200	COG0509	glycine decarboxylation via glycine cleavage system
TT65_RS13205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TT65_RS13215	COG1178	ABC-type Fe3 transport system permease component
TT65_RS13225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TT65_RS13230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TT65_RS13235	COG0006	proline dipeptidase activity
TT65_RS13240	COG3079	Belongs to the UPF0149 family
TT65_RS13255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TT65_RS13260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TT65_RS13265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TT65_RS13300	COG0126	phosphoglycerate kinase activity
TT65_RS13305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TT65_RS13310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TT65_RS13315	COG0640	Transcriptional regulator
TT65_RS13320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TT65_RS13325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TT65_RS13330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TT65_RS13340	COG0469	pyruvate kinase activity
TT65_RS13355	COG0534	Mate efflux family protein
TT65_RS13370	COG3123	guanosine phosphorylase activity
TT65_RS13400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TT65_RS13400	COG0678	peroxiredoxin activity
TT65_RS13405	COG0783	Belongs to the Dps family
TT65_RS13410	COG1272	protein, Hemolysin III
TT65_RS13415	COG0640	Transcriptional regulator
TT65_RS13430	COG0386	Belongs to the glutathione peroxidase family
TT65_RS13465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TT65_RS13480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TT65_RS13490	COG1320	monovalent cation:proton antiporter activity
TT65_RS13495	COG2212	antiporter activity
TT65_RS13500	COG1863	multisubunit Na H antiporter MnhE subunit
TT65_RS13505	COG0651	ATP synthesis coupled electron transport
TT65_RS13510	COG1006	Multisubunit Na H antiporter MnhC subunit
TT65_RS13515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TT65_RS13515	COG2111	Na H antiporter
TT65_RS13535	COG1960	acyl-CoA dehydrogenase activity
TT65_RS13550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT65_RS13555	COG3447	MASE1 domain protein
TT65_RS13555	COG5001	Diguanylate cyclase
TT65_RS13555	COG5002	protein histidine kinase activity
TT65_RS13585	COG2900	Belongs to the SlyX family
TT65_RS13590	COG2119	membrane
TT65_RS13610	COG0431	NADPH-dependent FMN reductase
TT65_RS13615	COG0798	PFAM Bile acid sodium symporter
TT65_RS13620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT65_RS13625	COG0640	Transcriptional regulator
TT65_RS13630	COG0704	Plays a role in the regulation of phosphate uptake
TT65_RS13635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TT65_RS13640	COG0581	inorganic phosphate transmembrane transporter activity
TT65_RS13645	COG0573	inorganic phosphate transmembrane transporter activity
TT65_RS13665	COG1607	acyl-coa hydrolase
TT65_RS13670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT65_RS13675	COG0210	DNA helicase
TT65_RS13695	COG0668	transmembrane transport
TT65_RS13715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TT65_RS13730	COG1793	dna ligase
TT65_RS13735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TT65_RS13735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TT65_RS13740	COG2354	Protein conserved in bacteria
TT65_RS13750	COG2909	trisaccharide binding
TT65_RS13755	COG3239	Fatty acid desaturase
TT65_RS13825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TT65_RS13835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TT65_RS13840	COG0830	nickel cation binding
TT65_RS13845	COG0830	nickel cation binding
TT65_RS13855	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TT65_RS13860	COG0804	urea catabolic process
TT65_RS13865	COG0832	Belongs to the urease beta subunit family
TT65_RS13870	COG0831	urea catabolic process
TT65_RS13875	COG0829	nickel cation binding
TT65_RS13885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TT65_RS13890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TT65_RS13895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TT65_RS13900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TT65_RS13905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TT65_RS13910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TT65_RS13915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TT65_RS13925	COG0356	it plays a direct role in the translocation of protons across the membrane
TT65_RS13935	COG1475	DNA binding
TT65_RS13940	COG1192	Involved in chromosome partitioning
TT65_RS13945	COG0357	Ribosomal RNA small subunit methyltransferase G
TT65_RS13950	COG0445	tRNA wobble uridine modification
TT65_RS13960	COG1960	acyl-CoA dehydrogenase activity
TT65_RS13975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TT65_RS13980	COG0676	glucose-6-phosphate 1-epimerase activity
TT65_RS13985	COG1278	Cold shock
TT65_RS13995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TT65_RS14005	COG0318	PFAM AMP-dependent synthetase and ligase
TT65_RS14015	COG1309	transcriptional regulator
TT65_RS14025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TT65_RS14030	COG0706	membrane insertase activity
TT65_RS14035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TT65_RS14060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family