locus-tag	class	description
P40_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P40_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
P40_RS00020	COG0187	DNA topoisomerase II activity
P40_RS00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
P40_RS00055	COG0683	leucine binding
P40_RS00070	COG0751	glycine-tRNA ligase activity
P40_RS00080	COG2818	Glycosylase
P40_RS00085	COG0519	Catalyzes the synthesis of GMP from XMP
P40_RS00085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P40_RS00095	COG0110	maltose O-acetyltransferase activity
P40_RS00110	COG4067	protein conserved in archaea
P40_RS00110	COG0189	ligase activity
P40_RS00115	COG0179	Fumarylacetoacetate (FAA) hydrolase
P40_RS00120	COG0277	FAD linked oxidase domain protein
P40_RS00125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_RS00170	COG0405	Gamma-glutamyltransferase
P40_RS00190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
P40_RS00210	COG1414	Transcriptional regulator
P40_RS00230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
P40_RS00240	COG0429	hydrolase of the alpha beta-hydrolase fold
P40_RS00245	COG0330	HflC and HflK could
P40_RS00255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P40_RS00260	COG0154	amidase activity
P40_RS00265	COG0640	Transcriptional regulator
P40_RS00280	COG2814	Major facilitator Superfamily
P40_RS00295	COG0433	COG0433 Predicted ATPase
P40_RS00300	COG1047	Peptidyl-prolyl cis-trans
P40_RS00320	COG2201	protein-glutamate methylesterase activity
P40_RS00335	COG0840	transmembrane signaling receptor activity
P40_RS00355	COG0189	ligase activity
P40_RS00365	COG1678	Uncharacterized ACR, COG1678
P40_RS00370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P40_RS00380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
P40_RS00385	COG0540	Belongs to the ATCase OTCase family
P40_RS00400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P40_RS00425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
P40_RS00430	COG0435	Glutathione S-transferase
P40_RS00470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_RS00500	COG1960	acyl-CoA dehydrogenase activity
P40_RS00520	COG3239	Fatty acid desaturase
P40_RS00530	COG0789	Transcriptional regulator
P40_RS00535	COG0415	Belongs to the DNA photolyase family
P40_RS00575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
P40_RS00580	COG0642	Histidine kinase
P40_RS00600	COG1024	Enoyl-CoA hydratase
P40_RS00605	COG1960	acyl-CoA dehydrogenase activity
P40_RS00615	COG0183	Belongs to the thiolase family
P40_RS00625	COG3618	amidohydrolase
P40_RS00630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P40_RS00635	COG0569	domain protein
P40_RS00645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P40_RS00650	COG0242	peptide deformylase activity
P40_RS00660	COG0758	DNA mediated transformation
P40_RS00665	COG0009	L-threonylcarbamoyladenylate synthase
P40_RS00670	COG0408	coproporphyrinogen oxidase activity
P40_RS00675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
P40_RS00685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
P40_RS00690	COG0339	signal peptide processing
P40_RS00740	COG0583	DNA-binding transcription factor activity
P40_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P40_RS00760	COG0583	DNA-binding transcription factor activity
P40_RS00770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P40_RS00775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P40_RS00780	COG2272	Belongs to the type-B carboxylesterase lipase family
P40_RS00810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P40_RS00815	COG1758	RNA polymerase activity
P40_RS00820	COG0194	GDP metabolic process
P40_RS00825	COG3608	succinylglutamate desuccinylase aspartoacylase
P40_RS00840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS00845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_RS00885	COG1561	YicC-like family, N-terminal region
P40_RS00890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
P40_RS00895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P40_RS00905	COG1309	transcriptional regulator
P40_RS00910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P40_RS00920	COG0756	dUTP diphosphatase activity
P40_RS00925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P40_RS00930	COG2003	Belongs to the UPF0758 family
P40_RS00935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P40_RS00940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P40_RS00965	COG4964	Belongs to the GSP D family
P40_RS01005	COG1414	Transcriptional regulator
P40_RS01015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS01060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P40_RS01080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_RS01085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS01090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P40_RS01100	COG2813	Specifically methylates the guanine in position
P40_RS01100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_RS01105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_RS01120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P40_RS01125	COG2022	thiamine diphosphate biosynthetic process
P40_RS01135	COG2363	Small membrane protein
P40_RS01145	COG2177	Part of the ABC transporter FtsEX involved in
P40_RS01150	COG2884	Cell division ATP-binding protein ftsE
P40_RS01155	COG0552	protein localization to endoplasmic reticulum
P40_RS01160	COG0612	Peptidase, M16
P40_RS01170	COG0742	ribosomal rna small subunit methyltransferase
P40_RS01190	COG3123	guanosine phosphorylase activity
P40_RS01200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
P40_RS01205	COG0402	S-adenosylhomocysteine deaminase activity
P40_RS01210	COG0534	Mate efflux family protein
P40_RS01230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
P40_RS01245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
P40_RS01255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P40_RS01260	COG0640	Transcriptional regulator
P40_RS01270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P40_RS01275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P40_RS01280	COG0126	phosphoglycerate kinase activity
P40_RS01315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
P40_RS01330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P40_RS01335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
P40_RS01355	COG3079	Belongs to the UPF0149 family
P40_RS01360	COG0006	proline dipeptidase activity
P40_RS01365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P40_RS01370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P40_RS01380	COG1178	ABC-type Fe3 transport system permease component
P40_RS01395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
P40_RS01400	COG0509	glycine decarboxylation via glycine cleavage system
P40_RS01405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P40_RS01410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P40_RS01485	COG1063	alcohol dehydrogenase
P40_RS01490	COG1942	4-Oxalocrotonate Tautomerase
P40_RS01515	COG3609	addiction module antidote protein, CC2985 family
P40_RS01535	COG0346	lactoylglutathione lyase activity
P40_RS01570	COG1944	ATP diphosphatase activity
P40_RS01590	COG0625	glutathione transferase activity
P40_RS01600	COG0604	alcohol dehydrogenase
P40_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS01600	COG3321	synthase
P40_RS01620	COG2226	methyltransferase
P40_RS01655	COG0456	acetyltransferase
P40_RS01660	COG0625	glutathione transferase activity
P40_RS01715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_RS01735	COG1960	acyl-CoA dehydrogenase activity
P40_RS01745	COG1652	LysM domain
P40_RS01745	COG2823	Periplasmic or secreted lipoprotein
P40_RS01765	COG3738	Protein conserved in bacteria
P40_RS01775	COG0625	glutathione transferase activity
P40_RS01805	COG0431	NADPH-dependent FMN reductase
P40_RS01815	COG0596	Alpha beta hydrolase
P40_RS01820	COG2824	Alkylphosphonate utilization operon protein PhnA
P40_RS01825	COG2031	fatty acid transporter
P40_RS01835	COG0656	L-ascorbic acid biosynthetic process
P40_RS01840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P40_RS01845	COG1690	Belongs to the RtcB family
P40_RS01860	COG2358	TRAP transporter, solute receptor (TAXI family
P40_RS01900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS01910	COG4399	Belongs to the UPF0754 family
P40_RS01920	COG0346	lactoylglutathione lyase activity
P40_RS01985	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS01995	COG2974	May be involved in recombination
P40_RS02005	COG3795	YCII-related domain
P40_RS02010	COG4941	Belongs to the sigma-70 factor family
P40_RS02030	COG0659	secondary active sulfate transmembrane transporter activity
P40_RS02045	COG2321	neutral zinc metallopeptidase
P40_RS02065	COG0515	serine threonine protein kinase
P40_RS02065	COG2815	serine threonine protein kinase
P40_RS02070	COG2116	formate transmembrane transporter activity
P40_RS02075	COG0586	Pfam SNARE associated Golgi protein
P40_RS02080	COG0625	glutathione transferase activity
P40_RS02090	COG0583	DNA-binding transcription factor activity
P40_RS02100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P40_RS02120	COG0513	Belongs to the DEAD box helicase family
P40_RS02145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P40_RS02150	COG2217	Heavy metal translocating P-type atpase
P40_RS02170	COG1051	belongs to the nudix hydrolase family
P40_RS02175	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
P40_RS02185	COG0730	response to heat
P40_RS02190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P40_RS02195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
P40_RS02240	COG0488	(ABC) transporter
P40_RS02250	COG1742	UPF0060 membrane protein
P40_RS02275	COG1960	acyl-CoA dehydrogenase activity
P40_RS02290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P40_RS02290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P40_RS02295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_RS02300	COG0439	Biotin carboxylase
P40_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS02315	COG0545	Peptidyl-prolyl cis-trans isomerase
P40_RS02335	COG1346	cytolysis
P40_RS02345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
P40_RS02350	COG2918	glutathione biosynthetic process
P40_RS02355	COG2183	response to ionizing radiation
P40_RS02375	COG2814	Major facilitator Superfamily
P40_RS02380	COG0129	dihydroxy-acid dehydratase activity
P40_RS02390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
P40_RS02395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_RS02405	COG2133	pyrroloquinoline quinone binding
P40_RS02410	COG0625	glutathione transferase activity
P40_RS02430	COG1309	transcriptional regulator
P40_RS02450	COG1595	DNA-templated transcription, initiation
P40_RS02455	COG3712	iron ion homeostasis
P40_RS02460	COG4771	TonB-dependent receptor
P40_RS02470	COG2951	lytic endotransglycosylase activity
P40_RS02480	COG1252	NADH dehydrogenase
P40_RS02485	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS02490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS02495	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS02515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P40_RS02525	COG3391	amine dehydrogenase activity
P40_RS02540	COG2207	Transcriptional regulator
P40_RS02545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
P40_RS02550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
P40_RS02555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
P40_RS02560	COG1011	Hydrolase
P40_RS02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_RS02575	COG0494	nUDIX hydrolase
P40_RS02580	COG1218	3'(2'),5'-bisphosphate nucleotidase
P40_RS02620	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS02635	COG0747	negative chemotaxis
P40_RS02640	COG4608	Belongs to the ABC transporter superfamily
P40_RS02645	COG0444	Belongs to the ABC transporter superfamily
P40_RS02660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_RS02730	COG0560	Phosphoserine phosphatase
P40_RS02730	COG3830	Belongs to the UPF0237 family
P40_RS02750	COG0131	Imidazoleglycerol-phosphate dehydratase
P40_RS02755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P40_RS02760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
P40_RS02765	COG0107	imidazoleglycerol-phosphate synthase activity
P40_RS02770	COG1671	Belongs to the UPF0178 family
P40_RS02785	COG0385	Bile acid
P40_RS02790	COG2223	nitrite transmembrane transporter activity
P40_RS02795	COG2146	nitrite reductase [NAD(P)H] activity
P40_RS02795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_RS02800	COG0243	molybdopterin cofactor binding
P40_RS02805	COG0746	molybdenum cofactor guanylyltransferase activity
P40_RS02820	COG0314	molybdopterin synthase activity
P40_RS02825	COG0315	cyclic pyranopterin monophosphate synthase activity
P40_RS02825	COG0521	Mo-molybdopterin cofactor biosynthetic process
P40_RS02830	COG0303	'Molybdopterin
P40_RS02835	COG0793	Belongs to the peptidase S41A family
P40_RS02840	COG4942	peptidase
P40_RS02845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_RS02855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
P40_RS02860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P40_RS02865	COG3237	CsbD-like
P40_RS02870	COG1217	gtp-binding protein TYPA
P40_RS02885	COG0189	ligase activity
P40_RS02890	COG3083	sulfuric ester hydrolase activity
P40_RS02895	COG0482	sulfurtransferase activity
P40_RS02905	COG0174	glutamine synthetase
P40_RS02920	COG3852	Histidine kinase
P40_RS02925	COG2204	response regulator
P40_RS02935	COG1490	D-aminoacyl-tRNA deacylase activity
P40_RS02950	COG1073	alpha beta
P40_RS02950	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
P40_RS02950	COG3064	Membrane
P40_RS02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P40_RS02965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P40_RS02970	COG0140	phosphoribosyl-ATP diphosphatase activity
P40_RS02975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_RS02985	COG2226	methyltransferase
P40_RS02995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P40_RS02995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
P40_RS03000	COG0306	phosphate transporter
P40_RS03005	COG1392	Phosphate transport regulator
P40_RS03010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P40_RS03025	COG0859	PFAM glycosyl transferase family 9
P40_RS03035	COG0859	PFAM glycosyl transferase family 9
P40_RS03040	COG0438	transferase activity, transferring glycosyl groups
P40_RS03075	COG1560	Kdo2-lipid A biosynthetic process
P40_RS03085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
P40_RS03085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
P40_RS03090	COG2207	Transcriptional regulator
P40_RS03100	COG0667	Aldo Keto reductase
P40_RS03110	COG1519	Transferase
P40_RS03115	COG1538	Outer membrane efflux protein
P40_RS03120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P40_RS03125	COG0494	nUDIX hydrolase
P40_RS03135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
P40_RS03160	COG3321	synthase
P40_RS03160	COG0604	alcohol dehydrogenase
P40_RS03165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_RS03175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_RS03185	COG0183	Belongs to the thiolase family
P40_RS03190	COG4566	intracellular signal transduction
P40_RS03195	COG5507	3-demethylubiquinone-9 3-methyltransferase
P40_RS03200	COG1283	sodium-dependent phosphate transmembrane transporter activity
P40_RS03205	COG3150	esterase
P40_RS03220	COG0204	Acyl-transferase
P40_RS03230	COG3122	Protein conserved in bacteria
P40_RS03240	COG2366	antibiotic biosynthetic process
P40_RS03245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P40_RS03260	COG0596	Alpha beta hydrolase
P40_RS03270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P40_RS03275	COG1509	lysine 2,3-aminomutase activity
P40_RS03310	COG1024	Enoyl-CoA hydratase
P40_RS03335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_RS03340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS03345	COG0583	DNA-binding transcription factor activity
P40_RS03350	COG0667	Aldo Keto reductase
P40_RS03360	COG1024	Enoyl-CoA hydratase
P40_RS03380	COG0473	3-isopropylmalate dehydrogenase activity
P40_RS03385	COG1902	pentaerythritol trinitrate reductase activity
P40_RS03390	COG2207	Transcriptional regulator
P40_RS03395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS03410	COG3781	membrane
P40_RS03415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P40_RS03420	COG2375	cellular response to nickel ion
P40_RS03430	COG3239	Fatty acid desaturase
P40_RS03445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
P40_RS03450	COG0259	pyridoxamine-phosphate oxidase activity
P40_RS03475	COG2161	toxin-antitoxin pair type II binding
P40_RS03490	COG0410	ABC transporter
P40_RS03505	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_RS03515	COG1802	Transcriptional regulator
P40_RS03520	COG0439	Biotin carboxylase
P40_RS03530	COG0583	DNA-binding transcription factor activity
P40_RS03550	COG1079	Belongs to the binding-protein-dependent transport system permease family
P40_RS03555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_RS03565	COG3845	ABC transporter
P40_RS03570	COG1335	isochorismatase
P40_RS03585	COG0739	heme binding
P40_RS03595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
P40_RS03600	COG1194	a g-specific adenine glycosylase
P40_RS03615	COG0688	phosphatidylethanolamine metabolic process
P40_RS03625	COG1162	GTPase activity
P40_RS03630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
P40_RS03650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P40_RS03650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P40_RS03655	COG0802	atpase or kinase
P40_RS03660	COG0860	N-Acetylmuramoyl-L-alanine amidase
P40_RS03665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
P40_RS03670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P40_RS03675	COG1923	regulation of RNA biosynthetic process
P40_RS03680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
P40_RS03685	COG0330	HflC and HflK could
P40_RS03690	COG0330	HflC and HflK could
P40_RS03700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
P40_RS03705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
P40_RS03720	COG1785	Belongs to the alkaline phosphatase family
P40_RS03725	COG1785	Belongs to the alkaline phosphatase family
P40_RS03755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P40_RS03760	COG0360	Binds together with S18 to 16S ribosomal RNA
P40_RS03770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P40_RS03775	COG0359	binds to the 23S rRNA
P40_RS03780	COG0305	Participates in initiation and elongation during chromosome replication
P40_RS03785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P40_RS03790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P40_RS03795	COG0569	domain protein
P40_RS03800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P40_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P40_RS03825	COG2226	methyltransferase
P40_RS03840	COG2259	Doxx family
P40_RS03850	COG1595	DNA-templated transcription, initiation
P40_RS03855	COG0488	(ABC) transporter
P40_RS03865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
P40_RS03875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P40_RS03880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P40_RS03880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P40_RS03910	COG3396	Phenylacetate-CoA oxygenase
P40_RS03915	COG3460	Phenylacetate-CoA oxygenase
P40_RS03920	COG3396	Phenylacetate-CoA oxygenase
P40_RS03925	COG2151	metal-sulfur cluster biosynthetic enzyme
P40_RS03930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_RS03935	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS03935	COG2030	dehydratase
P40_RS03955	COG1403	HNH endonuclease
P40_RS03960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
P40_RS03975	COG0737	Belongs to the 5'-nucleotidase family
P40_RS03980	COG0456	acetyltransferase
P40_RS04025	COG3327	negative regulation of DNA-templated transcription, initiation
P40_RS04030	COG1024	Enoyl-CoA hydratase
P40_RS04035	COG2050	protein possibly involved in aromatic compounds catabolism
P40_RS04040	COG0183	Belongs to the thiolase family
P40_RS04075	COG0583	DNA-binding transcription factor activity
P40_RS04100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
P40_RS04105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P40_RS04110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P40_RS04115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
P40_RS04120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P40_RS04125	COG0142	geranyltranstransferase activity
P40_RS04145	COG0745	RESPONSE REGULATOR receiver
P40_RS04150	COG3539	Fimbrial protein
P40_RS04155	COG3121	Chaperone
P40_RS04165	COG3539	Fimbrial protein
P40_RS04175	COG2205	protein histidine kinase activity
P40_RS04175	COG0784	Response regulator, receiver
P40_RS04185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_RS04205	COG5002	protein histidine kinase activity
P40_RS04215	COG0662	Cupin 2, conserved barrel domain protein
P40_RS04220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
P40_RS04230	COG1846	Transcriptional regulator
P40_RS04235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_RS04245	COG1469	GTP cyclohydrolase I activity
P40_RS04270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
P40_RS04275	COG0215	cysteine-tRNA ligase activity
P40_RS04280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
P40_RS04290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
P40_RS04290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
P40_RS04295	COG4251	negative regulation of phosphorylation
P40_RS04295	COG3706	GGDEF domain
P40_RS04295	COG5001	Diguanylate cyclase
P40_RS04295	COG2203	Gaf domain
P40_RS04315	COG0537	adenosine 5'-monophosphoramidase activity
P40_RS04330	COG1307	EDD domain protein, DegV family
P40_RS04350	COG0300	oxidoreductase activity
P40_RS04385	COG1335	isochorismatase
P40_RS04400	COG2835	tetraacyldisaccharide 4'-kinase activity
P40_RS04405	COG1960	acyl-CoA dehydrogenase activity
P40_RS04410	COG2832	Protein of unknown function (DUF454)
P40_RS04415	COG1960	acyl-CoA dehydrogenase activity
P40_RS04465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_RS04495	COG2771	luxR family
P40_RS04505	COG2771	luxR family
P40_RS04585	COG2354	Protein conserved in bacteria
P40_RS04590	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS04595	COG1024	Enoyl-CoA hydratase
P40_RS04620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P40_RS04635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P40_RS04640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P40_RS04645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P40_RS04650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P40_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS04670	COG0617	tRNA 3'-terminal CCA addition
P40_RS04680	COG2719	SpoVR family
P40_RS04685	COG2718	Belongs to the UPF0229 family
P40_RS04690	COG2766	serine protein kinase
P40_RS04700	COG2967	ApaG domain
P40_RS04705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P40_RS04710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
P40_RS04715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_RS04720	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
P40_RS04735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
P40_RS04745	COG0791	NLP P60 protein
P40_RS04760	COG0477	Major facilitator Superfamily
P40_RS04765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P40_RS04770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P40_RS04775	COG1845	cytochrome c oxidase, subunit III
P40_RS04780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
P40_RS04795	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_RS04800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P40_RS04805	COG0512	Glutamine amidotransferase of anthranilate synthase
P40_RS04810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P40_RS04815	COG0134	indole-3-glycerol-phosphate synthase activity
P40_RS04825	COG1765	OsmC-like protein
P40_RS04830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P40_RS04835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
P40_RS04840	COG0784	Response regulator, receiver
P40_RS04840	COG2205	protein histidine kinase activity
P40_RS04840	COG5002	protein histidine kinase activity
P40_RS04845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS04850	COG0730	response to heat
P40_RS04855	COG0151	Belongs to the GarS family
P40_RS04860	COG0138	bifunctional purine biosynthesis protein purh
P40_RS04865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
P40_RS04880	COG2264	protein methyltransferase activity
P40_RS04900	COG0511	ligase activity, forming carbon-carbon bonds
P40_RS04905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
P40_RS04920	COG2226	methyltransferase
P40_RS04945	COG0642	Histidine kinase
P40_RS04970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P40_RS04980	COG2233	PERMEase
P40_RS05025	COG0205	6-phosphofructokinase activity
P40_RS05040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P40_RS05045	COG0163	prenyltransferase activity
P40_RS05050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
P40_RS05065	COG0811	peptide transport
P40_RS05070	COG3015	lipoprotein NlpE involved in copper resistance
P40_RS05090	COG2807	transmembrane transport
P40_RS05095	COG1846	Transcriptional regulator
P40_RS05100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P40_RS05105	COG0321	lipoyl(octanoyl) transferase activity
P40_RS05120	COG1686	Belongs to the peptidase S11 family
P40_RS05130	COG2951	lytic endotransglycosylase activity
P40_RS05135	COG0772	Belongs to the SEDS family
P40_RS05140	COG0768	penicillin binding
P40_RS05145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
P40_RS05155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
P40_RS05160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
P40_RS05180	COG0495	leucyl-tRNA aminoacylation
P40_RS05190	COG0471	metal ion transport
P40_RS05195	COG0659	secondary active sulfate transmembrane transporter activity
P40_RS05200	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_RS05215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P40_RS05220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
P40_RS05225	COG4535	Mg2 and Co2 transporter CorC
P40_RS05230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P40_RS05235	COG1702	phosphate starvation-inducible protein PhoH
P40_RS05240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P40_RS05245	COG4208	sulfate ABC transporter
P40_RS05255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
P40_RS05265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P40_RS05270	COG1999	signal sequence binding
P40_RS05305	COG2020	methyltransferase activity
P40_RS05310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P40_RS05325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_RS05360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P40_RS05365	COG1278	Cold shock
P40_RS05380	COG0501	Belongs to the peptidase M48B family
P40_RS05385	COG1704	LemA family
P40_RS05390	COG0109	protoheme IX farnesyltransferase activity
P40_RS05395	COG1612	heme a metabolic process
P40_RS05425	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
P40_RS05430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P40_RS05435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P40_RS05500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
P40_RS05505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS05510	COG1022	Amp-dependent synthetase and ligase
P40_RS05545	COG3284	Transcriptional regulator
P40_RS05560	COG0439	Biotin carboxylase
P40_RS05575	COG1116	anion transmembrane transporter activity
P40_RS05580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_RS05605	COG2827	Endonuclease containing a URI domain
P40_RS05615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
P40_RS05640	COG0071	Belongs to the small heat shock protein (HSP20) family
P40_RS05665	COG2963	transposase activity
P40_RS05670	COG2801	Transposase and inactivated derivatives
P40_RS05680	COG1959	2 iron, 2 sulfur cluster binding
P40_RS05685	COG1104	cysteine desulfurase activity
P40_RS05695	COG2166	iron-sulfur cluster assembly
P40_RS05700	COG2151	metal-sulfur cluster biosynthetic enzyme
P40_RS05705	COG0316	Belongs to the HesB IscA family
P40_RS05710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P40_RS05715	COG0719	Fe-S assembly protein
P40_RS05720	COG0396	ATPase activity
P40_RS05725	COG0719	Fe-S assembly protein
P40_RS05730	COG0105	UTP biosynthetic process
P40_RS05735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
P40_RS05750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
P40_RS05755	COG0124	histidyl-tRNA synthetase
P40_RS05770	COG1160	GTP binding
P40_RS05785	COG2205	protein histidine kinase activity
P40_RS05785	COG5002	protein histidine kinase activity
P40_RS05785	COG0784	Response regulator, receiver
P40_RS05790	COG1570	exodeoxyribonuclease VII activity
P40_RS05800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P40_RS05800	COG0519	Catalyzes the synthesis of GMP from XMP
P40_RS05815	COG1230	cation diffusion facilitator family transporter
P40_RS05870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P40_RS05895	COG1752	Esterase of the alpha-beta hydrolase superfamily
P40_RS05900	COG1741	Belongs to the pirin family
P40_RS05905	COG0456	acetyltransferase
P40_RS05905	COG1846	Transcriptional regulator
P40_RS05950	COG3609	addiction module antidote protein, CC2985 family
P40_RS06005	COG1304	FMN binding
P40_RS06050	COG0024	Methionine aminopeptidase
P40_RS06080	COG2814	Major facilitator Superfamily
P40_RS06085	COG2272	Belongs to the type-B carboxylesterase lipase family
P40_RS06090	COG2272	Belongs to the type-B carboxylesterase lipase family
P40_RS06130	COG2207	Transcriptional regulator
P40_RS06130	COG0662	Cupin 2, conserved barrel domain protein
P40_RS06155	COG3457	Alanine racemase
P40_RS06170	COG2207	Transcriptional regulator
P40_RS06190	COG3541	Predicted nucleotidyltransferase
P40_RS06215	COG0625	glutathione transferase activity
P40_RS06235	COG0693	protein deglycase activity
P40_RS06240	COG4638	Rieske (2fe-2S)
P40_RS06250	COG0667	Aldo Keto reductase
P40_RS06295	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
P40_RS06325	COG2226	methyltransferase
P40_RS06330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
P40_RS06350	COG4993	Dehydrogenase
P40_RS06360	COG0477	Major facilitator Superfamily
P40_RS06370	COG0583	DNA-binding transcription factor activity
P40_RS06375	COG1960	acyl-CoA dehydrogenase activity
P40_RS06380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS06385	COG3795	YCII-related domain
P40_RS06400	COG0477	Major facilitator Superfamily
P40_RS06410	COG0583	DNA-binding transcription factor activity
P40_RS06415	COG1309	transcriptional regulator
P40_RS06430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P40_RS06440	COG1309	transcriptional regulator
P40_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS06450	COG2910	NAD(P)H-binding
P40_RS06470	COG1121	(ABC) transporter
P40_RS06475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_RS06480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_RS06485	COG2259	Doxx family
P40_RS06505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
P40_RS06520	COG1024	Enoyl-CoA hydratase
P40_RS06525	COG3258	Cytochrome c
P40_RS06530	COG0183	Belongs to the thiolase family
P40_RS06545	COG1309	transcriptional regulator
P40_RS06570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
P40_RS06580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
P40_RS06595	COG3323	Protein of unknown function (DUF1653)
P40_RS06595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
P40_RS06600	COG2816	NAD+ diphosphatase activity
P40_RS06605	COG0494	nUDIX hydrolase
P40_RS06620	COG1752	Esterase of the alpha-beta hydrolase superfamily
P40_RS06625	COG4536	flavin adenine dinucleotide binding
P40_RS06635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P40_RS06640	COG0228	four-way junction DNA binding
P40_RS06645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P40_RS06650	COG0336	Belongs to the RNA methyltransferase TrmD family
P40_RS06655	COG0335	large ribosomal subunit rRNA binding
P40_RS06660	COG2261	transglycosylase associated protein
P40_RS06675	COG0436	Aminotransferase
P40_RS06685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
P40_RS06700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
P40_RS06715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS06720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P40_RS06725	COG2264	protein methyltransferase activity
P40_RS06730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_RS06760	COG4953	penicillin-binding protein 1C
P40_RS06785	COG0488	(ABC) transporter
P40_RS06795	COG3264	Mechanosensitive ion channel
P40_RS06795	COG1196	nuclear chromosome segregation
P40_RS06810	COG0709	Synthesizes selenophosphate from selenide and ATP
P40_RS06815	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
P40_RS06825	COG1309	transcriptional regulator
P40_RS06850	COG3030	protein affecting phage T7 exclusion by the F plasmid
P40_RS06860	COG0183	Belongs to the thiolase family
P40_RS06865	COG1946	Acyl-CoA thioesterase
P40_RS06895	COG1902	pentaerythritol trinitrate reductase activity
P40_RS06895	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_RS06900	COG1960	acyl-CoA dehydrogenase activity
P40_RS06905	COG1960	acyl-CoA dehydrogenase activity
P40_RS06930	COG1115	amino acid carrier protein
P40_RS06960	COG3360	Dodecin
P40_RS06965	COG0513	Belongs to the DEAD box helicase family
P40_RS06995	COG4771	TonB-dependent receptor
P40_RS07005	COG0175	sulfate reduction
P40_RS07010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
P40_RS07010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
P40_RS07040	COG0488	(ABC) transporter
P40_RS07090	COG0183	Belongs to the thiolase family
P40_RS07095	COG1024	Enoyl-CoA hydratase
P40_RS07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_RS07100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P40_RS07115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P40_RS07125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
P40_RS07130	COG1024	Enoyl-CoA hydratase
P40_RS07135	COG2070	2-Nitropropane dioxygenase
P40_RS07180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_RS07185	COG0481	GTPase activity
P40_RS07190	COG0681	Belongs to the peptidase S26 family
P40_RS07200	COG0571	ribonuclease III activity
P40_RS07205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P40_RS07210	COG1381	Involved in DNA repair and RecF pathway recombination
P40_RS07215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P40_RS07225	COG0784	Response regulator, receiver
P40_RS07225	COG5002	protein histidine kinase activity
P40_RS07225	COG2205	protein histidine kinase activity
P40_RS07240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
P40_RS07245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P40_RS07250	COG3956	TIGRFAM MazG family protein
P40_RS07265	COG0789	Transcriptional regulator
P40_RS07300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P40_RS07310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P40_RS07315	COG3088	subunit of a heme lyase
P40_RS07325	COG0563	adenylate kinase activity
P40_RS07350	COG3630	sodium ion export across plasma membrane
P40_RS07355	COG0511	ligase activity, forming carbon-carbon bonds
P40_RS07355	COG5016	pyruvate
P40_RS07360	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
P40_RS07375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_RS07375	COG1116	anion transmembrane transporter activity
P40_RS07380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_RS07385	COG1116	anion transmembrane transporter activity
P40_RS07395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_RS07395	COG1116	anion transmembrane transporter activity
P40_RS07400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
P40_RS07405	COG0583	DNA-binding transcription factor activity
P40_RS07415	COG2954	triphosphatase activity
P40_RS07420	COG4133	protoheme IX ABC transporter activity
P40_RS07440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
P40_RS07450	COG0189	ligase activity
P40_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS07525	COG1131	(ABC) transporter
P40_RS07530	COG0842	Transport permease protein
P40_RS07535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P40_RS07535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P40_RS07545	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
P40_RS07555	COG0778	Nitroreductase
P40_RS07615	COG0583	DNA-binding transcription factor activity
P40_RS07620	COG0596	Alpha beta hydrolase
P40_RS07660	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS07665	COG2271	Major facilitator Superfamily
P40_RS07675	COG0183	Belongs to the thiolase family
P40_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS07690	COG1960	acyl-CoA dehydrogenase activity
P40_RS07695	COG1960	acyl-CoA dehydrogenase activity
P40_RS07705	COG1024	Enoyl-CoA hydratase
P40_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS07745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_RS07750	COG3829	transcription factor binding
P40_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS07785	COG0784	Response regulator, receiver
P40_RS07785	COG2205	protein histidine kinase activity
P40_RS07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_RS07840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_RS07845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS07850	COG1309	transcriptional regulator
P40_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS07875	COG0559	Belongs to the binding-protein-dependent transport system permease family
P40_RS07900	COG1024	Enoyl-CoA hydratase
P40_RS07900	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_RS07905	COG1960	acyl-CoA dehydrogenase activity
P40_RS07910	COG1960	acyl-CoA dehydrogenase activity
P40_RS07915	COG2130	NADP-dependent
P40_RS07925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
P40_RS07930	COG4774	siderophore transport
P40_RS07955	COG1487	ribonuclease activity
P40_RS07960	COG0281	malic enzyme
P40_RS07960	COG0280	phosphate acetyltransferase
P40_RS07965	COG0235	Class ii aldolase
P40_RS07980	COG1487	ribonuclease activity
P40_RS08000	COG2030	dehydratase
P40_RS08005	COG1960	acyl-CoA dehydrogenase activity
P40_RS08010	COG1024	Enoyl-CoA hydratase
P40_RS08015	COG1960	acyl-CoA dehydrogenase activity
P40_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS08025	COG2358	TRAP transporter, solute receptor (TAXI family
P40_RS08060	COG0183	Belongs to the thiolase family
P40_RS08065	COG1846	Transcriptional regulator
P40_RS08070	COG1764	response to oxidative stress
P40_RS08105	COG1739	Uncharacterized protein family UPF0029
P40_RS08135	COG0471	metal ion transport
P40_RS08135	COG3273	potassium ion transport
P40_RS08140	COG0529	Catalyzes the synthesis of activated sulfate
P40_RS08175	COG1078	dGTPase activity
P40_RS08185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
P40_RS08200	COG1045	serine acetyltransferase
P40_RS08205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P40_RS08210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P40_RS08215	COG1216	Glycosyl transferase, family 2
P40_RS08230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P40_RS08240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
P40_RS08270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
P40_RS08275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
P40_RS08275	COG2755	lipolytic protein G-D-S-L family
P40_RS08380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_RS08390	COG0183	Belongs to the thiolase family
P40_RS08395	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS08435	COG0436	Aminotransferase
P40_RS08475	COG2801	Transposase and inactivated derivatives
P40_RS08480	COG3791	Glutathione-dependent formaldehyde-activating
P40_RS08495	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_RS08500	COG3657	addiction module killer protein
P40_RS08510	COG3115	cell septum assembly
P40_RS08515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P40_RS08525	COG3089	Belongs to the UPF0270 family
P40_RS08530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
P40_RS08530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P40_RS08540	COG2267	carboxylic ester hydrolase activity
P40_RS08550	COG0784	Response regulator, receiver
P40_RS08550	COG2205	protein histidine kinase activity
P40_RS08550	COG5002	protein histidine kinase activity
P40_RS08560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS08580	COG4106	trans-aconitate 2-methyltransferase activity
P40_RS08585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P40_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS08620	COG0583	DNA-binding transcription factor activity
P40_RS08635	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS08640	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS08650	COG1024	Enoyl-CoA hydratase
P40_RS08655	COG1960	acyl-CoA dehydrogenase activity
P40_RS08660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_RS08700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS08705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P40_RS08715	COG0308	aminopeptidase N
P40_RS08725	COG0167	dihydroorotate dehydrogenase activity
P40_RS08735	COG3130	regulation of translation
P40_RS08740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
P40_RS08740	COG0116	Belongs to the methyltransferase superfamily
P40_RS08750	COG0084	hydrolase, TatD family'
P40_RS08760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P40_RS08770	COG0589	response to stress
P40_RS08790	COG1309	transcriptional regulator
P40_RS08795	COG1376	ErfK ybiS ycfS ynhG family protein
P40_RS08805	COG0668	transmembrane transport
P40_RS08810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
P40_RS08855	COG2081	HI0933 family
P40_RS08860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P40_RS08865	COG1946	Acyl-CoA thioesterase
P40_RS08875	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
P40_RS08895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
P40_RS08900	COG2871	sodium ion transport
P40_RS08905	COG1477	protein flavinylation
P40_RS08910	COG2991	Protein conserved in bacteria
P40_RS08925	COG0584	glycerophosphoryl diester phosphodiesterase
P40_RS08950	COG0583	DNA-binding transcription factor activity
P40_RS08975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_RS08980	COG2957	Belongs to the agmatine deiminase family
P40_RS08995	COG1136	(ABC) transporter
P40_RS09000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
P40_RS09010	COG0714	Associated with various cellular activities
P40_RS09045	COG1393	Belongs to the ArsC family
P40_RS09050	COG1295	ribonuclease BN
P40_RS09050	COG1959	2 iron, 2 sulfur cluster binding
P40_RS09055	COG1254	Belongs to the acylphosphatase family
P40_RS09070	COG0657	acetylesterase activity
P40_RS09095	COG1024	Enoyl-CoA hydratase
P40_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS09135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
P40_RS09140	COG2894	cell division
P40_RS09145	COG0850	regulation of cytokinetic process
P40_RS09155	COG3550	peptidyl-serine autophosphorylation
P40_RS09170	COG3118	belongs to the thioredoxin family
P40_RS09175	COG0004	ammonium transporteR
P40_RS09180	COG2326	polyphosphate kinase activity
P40_RS09190	COG1199	ATP-dependent helicase activity
P40_RS09205	COG1968	undecaprenyl-diphosphatase activity
P40_RS09210	COG0742	ribosomal rna small subunit methyltransferase
P40_RS09215	COG2937	Belongs to the GPAT DAPAT family
P40_RS09235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P40_RS09240	COG2171	N-acyltransferase activity
P40_RS09245	COG1393	Belongs to the ArsC family
P40_RS09250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_RS09255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
P40_RS09260	COG0024	Methionine aminopeptidase
P40_RS09265	COG0052	Belongs to the universal ribosomal protein uS2 family
P40_RS09270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P40_RS09275	COG0528	UMP kinase activity
P40_RS09280	COG0233	cytoplasmic translational termination
P40_RS09285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P40_RS09290	COG0575	Belongs to the CDS family
P40_RS09295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P40_RS09315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_RS09320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P40_RS09330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_RS09335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P40_RS09340	COG0587	DNA-directed DNA polymerase activity
P40_RS09345	COG0825	malonyl-CoA metabolic process
P40_RS09350	COG0037	tRNA processing
P40_RS09355	COG0504	CTP synthase activity
P40_RS09360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
P40_RS09365	COG0148	phosphopyruvate hydratase activity
P40_RS09370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
P40_RS09380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P40_RS09385	COG0585	pseudouridine synthase activity
P40_RS09390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
P40_RS09425	COG3001	Fructosamine kinase
P40_RS09430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P40_RS09440	COG0300	oxidoreductase activity
P40_RS09445	COG0037	tRNA processing
P40_RS09450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
P40_RS09455	COG0583	DNA-binding transcription factor activity
P40_RS09460	COG2814	Major facilitator Superfamily
P40_RS09465	COG0667	Aldo Keto reductase
P40_RS09470	COG0667	Aldo Keto reductase
P40_RS09485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P40_RS09495	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
P40_RS09505	COG2850	peptidyl-arginine hydroxylation
P40_RS09515	COG2915	High frequency lysogenization protein hflD homolog
P40_RS09520	COG0482	sulfurtransferase activity
P40_RS09540	COG1278	Cold shock
P40_RS09545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P40_RS09550	COG0542	response to heat
P40_RS09555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P40_RS09560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
P40_RS09565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS09575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
P40_RS09580	COG0492	ferredoxin-NADP+ reductase activity
P40_RS09585	COG1674	ftsk spoiiie
P40_RS09590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
P40_RS09595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P40_RS09600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
P40_RS09605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P40_RS09610	COG1648	precorrin-2 dehydrogenase activity
P40_RS09610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
P40_RS09615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P40_RS09630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
P40_RS09670	COG2274	protein secretion by the type I secretion system
P40_RS09675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS09680	COG0596	Alpha beta hydrolase
P40_RS09695	COG3243	poly(R)-hydroxyalkanoic acid synthase
P40_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS09730	COG0477	Major facilitator Superfamily
P40_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS09770	COG1960	acyl-CoA dehydrogenase activity
P40_RS09775	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
P40_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS09805	COG1960	acyl-CoA dehydrogenase activity
P40_RS09810	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS09815	COG1802	Transcriptional regulator
P40_RS09825	COG1280	lysine exporter protein (LysE YggA)
P40_RS09830	COG0003	Pfam Anion-transporting ATPase
P40_RS09840	COG1966	Carbon starvation protein
P40_RS09850	COG0322	excinuclease ABC activity
P40_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS09930	COG1960	acyl-CoA dehydrogenase activity
P40_RS09985	COG1021	2,3-dihydroxybenzoate-AMP ligase
P40_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS10010	COG2030	dehydratase
P40_RS10015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P40_RS10040	COG0657	acetylesterase activity
P40_RS10060	COG0633	Ferredoxin
P40_RS10080	COG1309	transcriptional regulator
P40_RS10095	COG2801	Transposase and inactivated derivatives
P40_RS10140	COG3209	COG3209 Rhs family protein
P40_RS10225	COG1074	ATP-dependent DNA helicase activity
P40_RS10400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P40_RS10485	COG1192	Involved in chromosome partitioning
P40_RS10490	COG1414	Transcriptional regulator
P40_RS10495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
P40_RS10505	COG0411	ABC transporter
P40_RS10520	COG0683	leucine binding
P40_RS10555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
P40_RS10560	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS10585	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS10765	COG0784	Response regulator, receiver
P40_RS10765	COG2205	protein histidine kinase activity
P40_RS10770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
P40_RS10785	COG3437	response regulator, receiver
P40_RS10820	COG3156	type II secretion system protein K
P40_RS10845	COG1410	methionine synthase
P40_RS10845	COG0646	methionine synthase
P40_RS10860	COG2813	Specifically methylates the guanine in position
P40_RS10865	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
P40_RS10870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
P40_RS10875	COG0235	Class ii aldolase
P40_RS10880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
P40_RS10915	COG0560	Phosphoserine phosphatase
P40_RS10920	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
P40_RS10930	COG2816	NAD+ diphosphatase activity
P40_RS10940	COG0616	signal peptide processing
P40_RS10945	COG0604	alcohol dehydrogenase
P40_RS10960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_RS10970	COG0534	Mate efflux family protein
P40_RS10975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P40_RS10975	COG0316	Belongs to the HesB IscA family
P40_RS10985	COG0501	Belongs to the peptidase M48B family
P40_RS10990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_RS11005	COG0564	pseudouridine synthase activity
P40_RS11010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_RS11030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P40_RS11075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P40_RS11090	COG0700	Nucleoside recognition
P40_RS11100	COG0598	Magnesium transport protein CorA
P40_RS11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_RS11115	COG3022	response to hydroperoxide
P40_RS11120	COG0589	response to stress
P40_RS11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS11155	COG0348	domain, Protein
P40_RS11160	COG2010	Cytochrome c
P40_RS11175	COG3278	Belongs to the heme-copper respiratory oxidase family
P40_RS11185	COG1902	pentaerythritol trinitrate reductase activity
P40_RS11185	COG0446	pyridine nucleotide-disulphide oxidoreductase
P40_RS11205	COG0583	DNA-binding transcription factor activity
P40_RS11210	COG0583	DNA-binding transcription factor activity
P40_RS11215	COG2814	Major facilitator Superfamily
P40_RS11235	COG0330	HflC and HflK could
P40_RS11240	COG0697	spore germination
P40_RS11265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
P40_RS11275	COG0180	Tryptophanyl-tRNA synthetase
P40_RS11280	COG0009	L-threonylcarbamoyladenylate synthase
P40_RS11285	COG0613	PHP domain protein
P40_RS11290	COG2917	probably involved in intracellular septation
P40_RS11295	COG2350	Protein conserved in bacteria
P40_RS11310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS11315	COG0204	Acyl-transferase
P40_RS11335	COG4181	ATPase activity
P40_RS11345	COG2814	Major facilitator Superfamily
P40_RS11360	COG1070	Carbohydrate kinase
P40_RS11365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
P40_RS11370	COG0277	FAD linked oxidase domain protein
P40_RS11375	COG2885	chlorophyll binding
P40_RS11400	COG3243	poly(R)-hydroxyalkanoic acid synthase
P40_RS11405	COG3339	Conserved Protein
P40_RS11410	COG1192	Involved in chromosome partitioning
P40_RS11425	COG0069	glutamate synthase activity
P40_RS11430	COG0741	lytic transglycosylase activity
P40_RS11445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
P40_RS11460	COG3344	reverse transcriptase
P40_RS11470	COG2079	MmgE PrpD family protein
P40_RS11475	COG2828	Protein conserved in bacteria
P40_RS11485	COG0372	Belongs to the citrate synthase family
P40_RS11490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
P40_RS11495	COG1802	Transcriptional regulator
P40_RS11510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P40_RS11515	COG0328	RNA-DNA hybrid ribonuclease activity
P40_RS11525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_RS11530	COG0741	lytic transglycosylase activity
P40_RS11530	COG1388	LysM domain
P40_RS11535	COG4166	transmembrane transport
P40_RS11540	COG4174	ABC transporter (Permease)
P40_RS11545	COG4239	(ABC) transporter, permease
P40_RS11550	COG4172	Belongs to the ABC transporter superfamily
P40_RS11560	COG0737	Belongs to the 5'-nucleotidase family
P40_RS11565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P40_RS11580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_RS11585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P40_RS11590	COG0740	serine-type endopeptidase activity
P40_RS11595	COG0544	peptidyl-prolyl cis-trans isomerase activity
P40_RS11615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P40_RS11630	COG1289	transmembrane transporter activity
P40_RS11640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_RS11655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P40_RS11670	COG1309	transcriptional regulator
P40_RS11680	COG2814	Major facilitator Superfamily
P40_RS11690	COG2814	Major facilitator Superfamily
P40_RS11710	COG3119	arylsulfatase activity
P40_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS11735	COG2301	Belongs to the HpcH HpaI aldolase family
P40_RS11740	COG2301	Belongs to the HpcH HpaI aldolase family
P40_RS11755	COG1960	acyl-CoA dehydrogenase activity
P40_RS11775	COG1960	acyl-CoA dehydrogenase activity
P40_RS11780	COG1960	acyl-CoA dehydrogenase activity
P40_RS11785	COG1024	Enoyl-CoA hydratase
P40_RS11805	COG2814	Major facilitator Superfamily
P40_RS11830	COG0438	transferase activity, transferring glycosyl groups
P40_RS11860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P40_RS11890	COG1643	Atp-dependent helicase
P40_RS11910	COG0583	DNA-binding transcription factor activity
P40_RS11930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
P40_RS11945	COG1054	Belongs to the UPF0176 family
P40_RS11950	COG0271	Belongs to the BolA IbaG family
P40_RS11965	COG0039	L-malate dehydrogenase activity
P40_RS11970	COG0517	IMP dehydrogenase activity
P40_RS11970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
P40_RS11970	COG0617	tRNA 3'-terminal CCA addition
P40_RS11975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
P40_RS11980	COG0702	epimerase
P40_RS11995	COG1960	acyl-CoA dehydrogenase activity
P40_RS12000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P40_RS12005	COG1024	Enoyl-CoA hydratase
P40_RS12015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS12030	COG0824	Thioesterase
P40_RS12060	COG0587	DNA-directed DNA polymerase activity
P40_RS12075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_RS12085	COG0589	response to stress
P40_RS12090	COG0659	secondary active sulfate transmembrane transporter activity
P40_RS12095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P40_RS12100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P40_RS12110	COG2853	Lipoprotein
P40_RS12120	COG3220	belongs to the UPF0276 family
P40_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS12140	COG1960	acyl-CoA dehydrogenase activity
P40_RS12145	COG1024	Enoyl-CoA hydratase
P40_RS12150	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS12190	COG1643	Atp-dependent helicase
P40_RS12205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
P40_RS12230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_RS12240	COG2271	Major facilitator Superfamily
P40_RS12265	COG4680	protein conserved in bacteria
P40_RS12275	COG4771	TonB-dependent receptor
P40_RS12280	COG1429	ligase activity, forming nitrogen-metal bonds
P40_RS12300	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_RS12320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS12325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_RS12350	COG2356	endonuclease I
P40_RS12355	COG1802	Transcriptional regulator
P40_RS12465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
P40_RS12470	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
P40_RS12480	COG0535	radical SAM domain protein
P40_RS12495	COG0625	glutathione transferase activity
P40_RS12505	COG0583	DNA-binding transcription factor activity
P40_RS12520	COG0745	RESPONSE REGULATOR receiver
P40_RS12525	COG5002	protein histidine kinase activity
P40_RS12565	COG2186	Transcriptional regulator
P40_RS12570	COG1620	l-lactate permease
P40_RS12575	COG0247	lactate metabolic process
P40_RS12580	COG1139	Iron-sulfur cluster binding protein
P40_RS12610	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_RS12690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P40_RS12705	COG4574	serine-type endopeptidase inhibitor activity
P40_RS12740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
P40_RS12745	COG1960	acyl-CoA dehydrogenase activity
P40_RS12750	COG1960	acyl-CoA dehydrogenase activity
P40_RS12755	COG1024	Enoyl-CoA hydratase
P40_RS12760	COG1024	Enoyl-CoA hydratase
P40_RS12765	COG1802	Transcriptional regulator
P40_RS12770	COG1960	acyl-CoA dehydrogenase activity
P40_RS12775	COG1960	acyl-CoA dehydrogenase activity
P40_RS12785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS12825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
P40_RS12830	COG3622	Belongs to the hyi family
P40_RS12835	COG0672	)-iron permease
P40_RS12845	COG0436	Aminotransferase
P40_RS12855	COG0501	Belongs to the peptidase M48B family
P40_RS12885	COG0714	Associated with various cellular activities
P40_RS12900	COG1286	toxin biosynthetic process
P40_RS12910	COG0285	dihydrofolate synthase activity
P40_RS12915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P40_RS12920	COG0159	tryptophan synthase activity
P40_RS12930	COG0135	phosphoribosylanthranilate isomerase activity
P40_RS12935	COG0101	tRNA pseudouridine synthase activity
P40_RS12945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P40_RS12955	COG0473	3-isopropylmalate dehydrogenase activity
P40_RS12960	COG0066	3-isopropylmalate dehydratase activity
P40_RS12965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
P40_RS12975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
P40_RS12995	COG1301	dicarboxylic acid transport
P40_RS13010	COG3268	Saccharopine dehydrogenase
P40_RS13020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P40_RS13030	COG0708	Exodeoxyribonuclease III
P40_RS13045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
P40_RS13050	COG0326	Molecular chaperone. Has ATPase activity
P40_RS13055	COG1090	epimerase
P40_RS13085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_RS13090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P40_RS13100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P40_RS13105	COG0045	succinate-CoA ligase (ADP-forming) activity
P40_RS13130	COG1053	succinate dehydrogenase
P40_RS13135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P40_RS13165	COG2084	Dehydrogenase
P40_RS13185	COG0579	oxidoreductase
P40_RS13195	COG1305	Transglutaminase-like
P40_RS13205	COG2308	Evidence 4 Homologs of previously reported genes of
P40_RS13230	COG0583	DNA-binding transcription factor activity
P40_RS13235	COG3153	acetyltransferase
P40_RS13235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_RS13245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
P40_RS13260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS13265	COG2146	nitrite reductase [NAD(P)H] activity
P40_RS13270	COG2146	nitrite reductase [NAD(P)H] activity
P40_RS13270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_RS13285	COG1104	cysteine desulfurase activity
P40_RS13305	COG0084	hydrolase, TatD family'
P40_RS13320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P40_RS13325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P40_RS13330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P40_RS13335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P40_RS13340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P40_RS13355	COG0416	fatty acid biosynthetic process
P40_RS13360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P40_RS13370	COG0424	maF-like protein
P40_RS13380	COG0546	phosphoglycolate phosphatase activity
P40_RS13385	COG0564	pseudouridine synthase activity
P40_RS13390	COG1530	ribonuclease E activity
P40_RS13400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P40_RS13405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P40_RS13410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
P40_RS13415	COG1663	tetraacyldisaccharide 4'-kinase activity
P40_RS13420	COG1132	(ABC) transporter
P40_RS13425	COG0848	biopolymer transport protein
P40_RS13430	COG0811	peptide transport
P40_RS13435	COG0658	competence protein
P40_RS13435	COG2333	competence protein COMEC
P40_RS13445	COG3101	peptidyl-lysine hydroxylation
P40_RS13450	COG0534	Mate efflux family protein
P40_RS13460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS13495	COG2223	nitrite transmembrane transporter activity
P40_RS13500	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
P40_RS13505	COG0788	formyltetrahydrofolate deformylase activity
P40_RS13510	COG2207	Transcriptional regulator
P40_RS13515	COG1309	transcriptional regulator
P40_RS13525	COG1131	(ABC) transporter
P40_RS13530	COG0842	Transport permease protein
P40_RS13540	COG4771	TonB-dependent receptor
P40_RS13590	COG4774	siderophore transport
P40_RS13595	COG3712	iron ion homeostasis
P40_RS13600	COG1595	DNA-templated transcription, initiation
P40_RS13605	COG1024	Enoyl-CoA hydratase
P40_RS13615	COG1960	acyl-CoA dehydrogenase activity
P40_RS13635	COG2358	TRAP transporter, solute receptor (TAXI family
P40_RS13645	COG2358	TRAP transporter, solute receptor (TAXI family
P40_RS13670	COG2193	ferroxidase activity
P40_RS13675	COG1024	Enoyl-CoA hydratase
P40_RS13675	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_RS13680	COG0183	Belongs to the thiolase family
P40_RS13690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P40_RS13700	COG2840	Smr protein MutS2
P40_RS13705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P40_RS13720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P40_RS13725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P40_RS13740	COG0717	Belongs to the dCTP deaminase family
P40_RS13745	COG0489	protein tyrosine kinase activity
P40_RS13760	COG0450	alkyl hydroperoxide reductase
P40_RS13800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
P40_RS13805	COG1793	dna ligase
P40_RS13810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P40_RS13815	COG2813	Specifically methylates the guanine in position
P40_RS13820	COG0741	lytic transglycosylase activity
P40_RS13825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
P40_RS13865	COG0784	Response regulator, receiver
P40_RS13865	COG2205	protein histidine kinase activity
P40_RS13865	COG5002	protein histidine kinase activity
P40_RS13870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P40_RS13870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P40_RS13885	COG4657	Part of a membrane complex involved in electron transport
P40_RS13890	COG2878	Part of a membrane complex involved in electron transport
P40_RS13895	COG4656	Part of a membrane complex involved in electron transport
P40_RS13900	COG4658	electron transport chain
P40_RS13905	COG4659	FMN binding
P40_RS13910	COG4660	Part of a membrane complex involved in electron transport
P40_RS13920	COG0786	glutamate:sodium symporter activity
P40_RS13925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P40_RS13930	COG1555	photosystem II stabilization
P40_RS13930	COG1596	polysaccharide export
P40_RS13935	COG0284	orotidine-5'-phosphate decarboxylase activity
P40_RS13940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
P40_RS13950	COG0776	regulation of translation
P40_RS13960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P40_RS13965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
P40_RS13970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_RS13975	COG0077	Prephenate dehydratase
P40_RS13975	COG1605	Chorismate mutase
P40_RS13990	COG0402	S-adenosylhomocysteine deaminase activity
P40_RS13995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P40_RS14000	COG0546	phosphoglycolate phosphatase activity
P40_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS14050	COG2226	methyltransferase
P40_RS14065	COG2983	Belongs to the UPF0260 family
P40_RS14070	COG3100	YcgL domain-containing protein
P40_RS14075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P40_RS14080	COG0588	phosphoglycerate mutase activity
P40_RS14085	COG5380	lipid catabolic process
P40_RS14090	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
P40_RS14100	COG1960	acyl-CoA dehydrogenase activity
P40_RS14105	COG1454	alcohol dehydrogenase
P40_RS14110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
P40_RS14115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
P40_RS14155	COG1695	Transcriptional regulator
P40_RS14175	COG0427	acetyl-CoA hydrolase
P40_RS14190	COG4181	ATPase activity
P40_RS14205	COG0418	dihydroorotase activity
P40_RS14235	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS14250	COG0477	Major facilitator Superfamily
P40_RS14260	COG0583	DNA-binding transcription factor activity
P40_RS14270	COG0659	secondary active sulfate transmembrane transporter activity
P40_RS14275	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS14280	COG4191	Histidine kinase
P40_RS14285	COG4566	intracellular signal transduction
P40_RS14290	COG0583	DNA-binding transcription factor activity
P40_RS14300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_RS14320	COG2070	2-Nitropropane dioxygenase
P40_RS14325	COG3189	MarR family transcriptional regulator
P40_RS14345	COG4890	Cyd operon protein YbgT
P40_RS14350	COG1294	oxidase, subunit
P40_RS14360	COG4988	ABC transporter
P40_RS14365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
P40_RS14370	COG0826	peptidase U32
P40_RS14375	COG0826	peptidase U32
P40_RS14390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P40_RS14395	COG3154	lipid carrier protein
P40_RS14400	COG2223	nitrite transmembrane transporter activity
P40_RS14405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
P40_RS14410	COG1140	nitrate reductase beta subunit
P40_RS14415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
P40_RS14420	COG2181	nitrate reductase activity
P40_RS14440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_RS14450	COG1959	2 iron, 2 sulfur cluster binding
P40_RS14455	COG1959	2 iron, 2 sulfur cluster binding
P40_RS14475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P40_RS14480	COG0840	transmembrane signaling receptor activity
P40_RS14515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
P40_RS14520	COG0527	aspartate kinase activity
P40_RS14525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P40_RS14540	COG2137	regulation of response to DNA damage stimulus
P40_RS14550	COG1546	Belongs to the CinA family
P40_RS14615	COG4771	TonB-dependent receptor
P40_RS14625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P40_RS14630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_RS14630	COG1017	nitric oxide dioxygenase activity
P40_RS14635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
P40_RS14640	COG1024	Enoyl-CoA hydratase
P40_RS14650	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS14655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P40_RS14660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P40_RS14710	COG1509	lysine 2,3-aminomutase activity
P40_RS14715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P40_RS14725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
P40_RS14730	COG1074	ATP-dependent DNA helicase activity
P40_RS14735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P40_RS14745	COG3784	Protein of unknown function (DUF1318)
P40_RS14775	COG3077	Addiction module antitoxin, RelB DinJ family
P40_RS14900	COG2003	Belongs to the UPF0758 family
P40_RS14955	COG2608	mercury ion transmembrane transporter activity
P40_RS14995	COG2132	Multicopper oxidase
P40_RS15020	COG2003	Belongs to the UPF0758 family
P40_RS15085	COG0789	Transcriptional regulator
P40_RS15140	COG0776	regulation of translation
P40_RS15150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P40_RS15155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P40_RS15160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P40_RS15165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P40_RS15180	COG2186	Transcriptional regulator
P40_RS15190	COG1271	oxidase subunit
P40_RS15195	COG1294	oxidase, subunit
P40_RS15205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P40_RS15210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
P40_RS15220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P40_RS15230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P40_RS15240	COG0425	Belongs to the sulfur carrier protein TusA family
P40_RS15250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
P40_RS15260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
P40_RS15265	COG0602	queuosine metabolic process
P40_RS15280	COG0823	Involved in the tonB-independent uptake of proteins
P40_RS15300	COG0824	Thioesterase
P40_RS15305	COG2255	four-way junction helicase activity
P40_RS15310	COG0632	four-way junction helicase activity
P40_RS15315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P40_RS15320	COG0217	transcriptional regulatory protein
P40_RS15325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P40_RS15345	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P40_RS15350	COG0729	surface antigen
P40_RS15365	COG0442	prolyl-tRNA aminoacylation
P40_RS15375	COG1192	Involved in chromosome partitioning
P40_RS15380	COG1960	acyl-CoA dehydrogenase activity
P40_RS15385	COG1309	transcriptional regulator
P40_RS15395	COG0514	ATP-dependent DNA helicase (RecQ)
P40_RS15410	COG0513	Belongs to the DEAD box helicase family
P40_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS15450	COG0189	ligase activity
P40_RS15455	COG0189	ligase activity
P40_RS15455	COG4067	protein conserved in archaea
P40_RS15460	COG0137	argininosuccinate synthase activity
P40_RS15465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P40_RS15480	COG0450	alkyl hydroperoxide reductase
P40_RS15500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P40_RS15505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
P40_RS15510	COG3842	ATPase activity
P40_RS15525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
P40_RS15530	COG2205	protein histidine kinase activity
P40_RS15535	COG0745	RESPONSE REGULATOR receiver
P40_RS15540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P40_RS15540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P40_RS15545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P40_RS15570	COG4651	solute:proton antiporter activity
P40_RS15570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
P40_RS15625	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS15630	COG3384	dioxygenase
P40_RS15660	COG1846	Transcriptional regulator
P40_RS15665	COG0683	leucine binding
P40_RS15670	COG0861	Integral membrane protein TerC family
P40_RS15685	COG0601	transmembrane transport
P40_RS15690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P40_RS15695	COG0444	Belongs to the ABC transporter superfamily
P40_RS15700	COG4608	Belongs to the ABC transporter superfamily
P40_RS15705	COG0747	negative chemotaxis
P40_RS15720	COG2197	response regulator
P40_RS15775	COG0705	Rhomboid family
P40_RS15785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P40_RS15805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_RS15820	COG1335	isochorismatase
P40_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS15835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P40_RS15840	COG1116	anion transmembrane transporter activity
P40_RS15865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
P40_RS15885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P40_RS15890	COG1611	Belongs to the LOG family
P40_RS15905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
P40_RS15910	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
P40_RS15945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
P40_RS15950	COG0735	belongs to the Fur family
P40_RS15960	COG1960	acyl-CoA dehydrogenase activity
P40_RS15965	COG0583	DNA-binding transcription factor activity
P40_RS15970	COG2814	Major facilitator Superfamily
P40_RS15980	COG2249	NAD(P)H dehydrogenase (quinone) activity
P40_RS15985	COG0583	DNA-binding transcription factor activity
P40_RS16025	COG0183	Belongs to the thiolase family
P40_RS16035	COG4993	Dehydrogenase
P40_RS16060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P40_RS16070	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS16085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
P40_RS16090	COG1191	sigma factor activity
P40_RS16110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
P40_RS16125	COG0745	RESPONSE REGULATOR receiver
P40_RS16130	COG0840	transmembrane signaling receptor activity
P40_RS16135	COG2201	protein-glutamate methylesterase activity
P40_RS16140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
P40_RS16145	COG0840	transmembrane signaling receptor activity
P40_RS16155	COG0835	chemotaxis
P40_RS16165	COG1360	Flagellar Motor Protein
P40_RS16185	COG2257	FlhB HrpN YscU SpaS Family
P40_RS16230	COG1677	Flagellar hook-basal body complex protein FliE
P40_RS16265	COG1580	Controls the rotational direction of flagella during chemotaxis
P40_RS16270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P40_RS16290	COG1987	bacterial-type flagellum assembly
P40_RS16300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P40_RS16310	COG1705	Flagellar rod assembly protein muramidase FlgJ
P40_RS16310	COG3951	Flagellar rod assembly protein muramidase FlgJ
P40_RS16315	COG1706	bacterial-type flagellum-dependent cell motility
P40_RS16340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
P40_RS16345	COG1558	bacterial-type flagellum-dependent cell motility
P40_RS16370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
P40_RS16395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_RS16415	COG3119	arylsulfatase activity
P40_RS16425	COG4585	Histidine kinase
P40_RS16430	COG0745	RESPONSE REGULATOR receiver
P40_RS16460	COG0459	protein refolding
P40_RS16465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P40_RS16475	COG2211	Major facilitator Superfamily
P40_RS16480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
P40_RS16485	COG2096	Adenosyltransferase
P40_RS16490	COG2205	protein histidine kinase activity
P40_RS16495	COG0745	RESPONSE REGULATOR receiver
P40_RS16530	COG1115	amino acid carrier protein
P40_RS16545	COG2358	TRAP transporter, solute receptor (TAXI family
P40_RS16580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P40_RS16585	COG0237	dephospho-CoA kinase activity
P40_RS16590	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
P40_RS16600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
P40_RS16605	COG0653	protein targeting
P40_RS16610	COG0739	heme binding
P40_RS16620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
P40_RS16635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
P40_RS16640	COG1181	Belongs to the D-alanine--D-alanine ligase family
P40_RS16645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P40_RS16650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P40_RS16655	COG0772	Belongs to the SEDS family
P40_RS16660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
P40_RS16665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P40_RS16670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P40_RS16675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P40_RS16690	COG0275	rRNA processing
P40_RS16695	COG2001	Belongs to the MraZ family
P40_RS16710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P40_RS16720	COG0792	nuclease activity
P40_RS16730	COG2823	Periplasmic or secreted lipoprotein
P40_RS16735	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS16750	COG3119	arylsulfatase activity
P40_RS16755	COG2969	positive regulation of protein catabolic process
P40_RS16760	COG0625	glutathione transferase activity
P40_RS16765	COG2857	Cytochrome c1
P40_RS16770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P40_RS16775	COG0723	plastoquinol--plastocyanin reductase activity
P40_RS16780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P40_RS16785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P40_RS16790	COG0667	Aldo Keto reductase
P40_RS16795	COG1309	transcriptional regulator
P40_RS16810	COG1802	Transcriptional regulator
P40_RS16845	COG1960	acyl-CoA dehydrogenase activity
P40_RS16880	COG2801	Transposase and inactivated derivatives
P40_RS16910	COG2067	long-chain fatty acid transport protein
P40_RS16915	COG1960	acyl-CoA dehydrogenase activity
P40_RS16920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
P40_RS16925	COG2945	thiolester hydrolase activity
P40_RS16935	COG2046	Belongs to the sulfate adenylyltransferase family
P40_RS16940	COG1597	lipid kinase activity
P40_RS16950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P40_RS16960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P40_RS16965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P40_RS16970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
P40_RS16975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P40_RS16980	COG5007	Belongs to the BolA IbaG family
P40_RS17000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
P40_RS17015	COG1137	ATPase activity
P40_RS17020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
P40_RS17035	COG1660	Displays ATPase and GTPase activities
P40_RS17050	COG0443	Heat shock 70 kDa protein
P40_RS17060	COG0312	modulator of DNA gyrase
P40_RS17065	COG3028	Belongs to the UPF0307 family
P40_RS17070	COG2807	transmembrane transport
P40_RS17075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P40_RS17075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P40_RS17080	COG0312	modulator of DNA gyrase
P40_RS17085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P40_RS17095	COG0424	maF-like protein
P40_RS17100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
P40_RS17105	COG1792	Involved in formation and maintenance of cell shape
P40_RS17110	COG1077	Cell shape determining protein MreB Mrl
P40_RS17115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P40_RS17120	COG0154	amidase activity
P40_RS17125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P40_RS17140	COG1024	Enoyl-CoA hydratase
P40_RS17220	COG3038	cytochrome b561
P40_RS17235	COG2205	protein histidine kinase activity
P40_RS17240	COG2197	response regulator
P40_RS17260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P40_RS17265	COG2890	protein-(glutamine-N5) methyltransferase activity
P40_RS17270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P40_RS17275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
P40_RS17285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
P40_RS17290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P40_RS17300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P40_RS17305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
P40_RS17310	COG0193	aminoacyl-tRNA hydrolase activity
P40_RS17320	COG0012	GTP binding
P40_RS17330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
P40_RS17410	COG1045	serine acetyltransferase
P40_RS17415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
P40_RS17425	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS17430	COG0473	3-isopropylmalate dehydrogenase activity
P40_RS17435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
P40_RS17445	COG0154	amidase activity
P40_RS17450	COG0436	Aminotransferase
P40_RS17460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P40_RS17465	COG1862	Preprotein translocase
P40_RS17470	COG0343	queuine tRNA-ribosyltransferase activity
P40_RS17475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
P40_RS17495	COG1192	Involved in chromosome partitioning
P40_RS17765	COG4115	mRNA cleavage
P40_RS17770	COG2161	toxin-antitoxin pair type II binding
P40_RS17785	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
P40_RS17900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P40_RS17910	COG0795	lipopolysaccharide-transporting ATPase activity
P40_RS17915	COG0795	lipopolysaccharide-transporting ATPase activity
P40_RS17920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P40_RS17930	COG0525	valine-tRNA ligase activity
P40_RS17945	COG1597	lipid kinase activity
P40_RS17975	COG1183	phosphatidylcholine synthase activity
P40_RS17980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
P40_RS17995	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS18005	COG1280	lysine exporter protein (LysE YggA)
P40_RS18015	COG0028	Belongs to the TPP enzyme family
P40_RS18110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
P40_RS18115	COG1047	Peptidyl-prolyl cis-trans
P40_RS18120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
P40_RS18125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P40_RS18130	COG0196	riboflavin kinase activity
P40_RS18135	COG0728	peptidoglycan biosynthetic process
P40_RS18140	COG0268	Binds directly to 16S ribosomal RNA
P40_RS18145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
P40_RS18150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P40_RS18155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P40_RS18160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P40_RS18165	COG0142	geranyltranstransferase activity
P40_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS18235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P40_RS18250	COG4221	oxidoreductase activity
P40_RS18255	COG2267	carboxylic ester hydrolase activity
P40_RS18290	COG2814	Major facilitator Superfamily
P40_RS18325	COG0659	secondary active sulfate transmembrane transporter activity
P40_RS18335	COG0203	ribosomal protein L17
P40_RS18340	COG0202	RNA polymerase activity
P40_RS18345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P40_RS18350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P40_RS18355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P40_RS18360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
P40_RS18370	COG0200	Binds to the 23S rRNA
P40_RS18375	COG1841	ribosomal large subunit assembly
P40_RS18380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P40_RS18385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P40_RS18390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P40_RS18395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P40_RS18400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P40_RS18405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P40_RS18410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P40_RS18415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P40_RS18420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P40_RS18425	COG0255	Belongs to the universal ribosomal protein uL29 family
P40_RS18430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P40_RS18435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P40_RS18440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P40_RS18445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P40_RS18450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P40_RS18455	COG0089	rRNA binding
P40_RS18460	COG0088	Forms part of the polypeptide exit tunnel
P40_RS18465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P40_RS18470	COG0051	transcription antitermination factor activity, RNA binding
P40_RS18475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P40_RS18480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P40_RS18485	COG0049	tRNA binding
P40_RS18490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P40_RS18495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P40_RS18500	COG0085	RNA polymerase activity
P40_RS18505	COG0222	ribosome binding
P40_RS18510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P40_RS18515	COG0081	regulation of translation
P40_RS18520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P40_RS18540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P40_RS18570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P40_RS18610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P40_RS18615	COG0739	heme binding
P40_RS18620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
P40_RS18630	COG0316	Belongs to the HesB IscA family
P40_RS18650	COG1981	membrane
P40_RS18655	COG0351	phosphomethylpyrimidine kinase
P40_RS18655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
P40_RS18655	COG0352	thiamine-phosphate diphosphorylase activity
P40_RS18660	COG0352	thiamine-phosphate diphosphorylase activity
P40_RS18665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
P40_RS18680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P40_RS18685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P40_RS18700	COG1489	DNA binding
P40_RS18705	COG0436	Aminotransferase
P40_RS18710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P40_RS18715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P40_RS18730	COG0617	tRNA 3'-terminal CCA addition
P40_RS18740	COG1428	Deoxynucleoside kinase
P40_RS18745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P40_RS18750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
P40_RS18755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
P40_RS18760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS18770	COG2814	Major facilitator Superfamily
P40_RS18790	COG1024	Enoyl-CoA hydratase
P40_RS18815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_RS18825	COG2186	Transcriptional regulator
P40_RS18840	COG3344	reverse transcriptase
P40_RS18850	COG1185	polyribonucleotide nucleotidyltransferase activity
P40_RS18855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P40_RS18865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
P40_RS18870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P40_RS18875	COG0195	Participates in both transcription termination and antitermination
P40_RS18880	COG0779	Required for maturation of 30S ribosomal subunits
P40_RS18900	COG0149	triose-phosphate isomerase activity
P40_RS18905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P40_RS18910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P40_RS18915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P40_RS18920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
P40_RS18940	COG0505	Belongs to the CarA family
P40_RS18945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
P40_RS18950	COG0484	heat shock protein binding
P40_RS18955	COG0443	Heat shock 70 kDa protein
P40_RS18960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P40_RS18965	COG1420	regulation of RNA biosynthetic process
P40_RS18970	COG0497	DNA recombination
P40_RS18985	COG2914	Belongs to the UPF0125 (RnfH) family
P40_RS18990	COG0733	neurotransmitter:sodium symporter activity
P40_RS18995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P40_RS19010	COG0582	viral genome integration into host DNA
P40_RS19020	COG0582	viral genome integration into host DNA
P40_RS19060	COG0395	ABC-type sugar transport system, permease component
P40_RS19070	COG1653	transport
P40_RS19075	COG3842	ATPase activity
P40_RS19090	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS19110	COG0667	Aldo Keto reductase
P40_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS19120	COG0583	DNA-binding transcription factor activity
P40_RS19145	COG0154	amidase activity
P40_RS19175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_RS19210	COG2807	transmembrane transport
P40_RS19225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_RS19230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P40_RS19240	COG0402	S-adenosylhomocysteine deaminase activity
P40_RS19245	COG3195	allantoin biosynthetic process
P40_RS19245	COG3648	Uricase
P40_RS19265	COG4266	Belongs to the allantoicase family
P40_RS19270	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
P40_RS19285	COG0583	DNA-binding transcription factor activity
P40_RS19310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P40_RS19315	COG0037	tRNA processing
P40_RS19315	COG0590	tRNA wobble adenosine to inosine editing
P40_RS19335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P40_RS19345	COG0505	Belongs to the CarA family
P40_RS19355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P40_RS19360	COG1522	sequence-specific DNA binding
P40_RS19390	COG1960	acyl-CoA dehydrogenase activity
P40_RS19405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P40_RS19455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P40_RS19460	COG2226	methyltransferase
P40_RS19465	COG0596	Alpha beta hydrolase
P40_RS19470	COG0156	8-amino-7-oxononanoate synthase activity
P40_RS19475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P40_RS19480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P40_RS19485	COG2045	Belongs to the ComB family
P40_RS19495	COG2154	pterin-4-alpha-carbinolamine dehydratase
P40_RS19505	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
P40_RS19510	COG0493	'glutamate synthase
P40_RS19515	COG0070	glutamate synthase
P40_RS19515	COG0069	glutamate synthase activity
P40_RS19515	COG0067	glutamate synthase
P40_RS19525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
P40_RS19530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
P40_RS19575	COG0281	malic enzyme
P40_RS19580	COG0254	rRNA binding
P40_RS19585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P40_RS19590	COG0477	Major facilitator Superfamily
P40_RS19595	COG1566	PFAM secretion protein HlyD family protein
P40_RS19600	COG0018	arginyl-trna synthetase
P40_RS19610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
P40_RS19615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
P40_RS19620	COG0129	dihydroxy-acid dehydratase activity
P40_RS19635	COG0543	2 iron, 2 sulfur cluster binding
P40_RS19635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P40_RS19640	COG2995	paraquat-inducible protein a
P40_RS19645	COG3008	intermembrane lipid transfer
P40_RS19645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P40_RS19670	COG0181	hydroxymethylbilane synthase activity
P40_RS19680	COG3275	phosphorelay sensor kinase activity
P40_RS19685	COG0165	Argininosuccinate lyase
P40_RS19695	COG0534	Mate efflux family protein
P40_RS19715	COG4774	siderophore transport
P40_RS19725	COG1595	DNA-templated transcription, initiation
P40_RS19745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
P40_RS19750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_RS19765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
P40_RS19770	COG2267	carboxylic ester hydrolase activity
P40_RS19785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
P40_RS19795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P40_RS19805	COG3098	single-species biofilm formation
P40_RS19810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
P40_RS19820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P40_RS19830	COG4774	siderophore transport
P40_RS19840	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
P40_RS19845	COG0248	Ppx GppA phosphatase
P40_RS19860	COG1335	isochorismatase
P40_RS19865	COG0583	DNA-binding transcription factor activity
P40_RS19875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
P40_RS19900	COG2205	protein histidine kinase activity
P40_RS19905	COG0745	RESPONSE REGULATOR receiver
P40_RS19910	COG3268	Saccharopine dehydrogenase
P40_RS19920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_RS19920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
P40_RS19930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P40_RS19935	COG2186	Transcriptional regulator
P40_RS19940	COG0154	amidase activity
P40_RS19945	COG0604	alcohol dehydrogenase
P40_RS19950	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS19965	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
P40_RS19990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
P40_RS19995	COG1595	DNA-templated transcription, initiation
P40_RS20025	COG3530	Putative quorum-sensing-regulated virulence factor
P40_RS20040	COG0789	Transcriptional regulator
P40_RS20045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P40_RS20050	COG3384	dioxygenase
P40_RS20060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
P40_RS20080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS20105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P40_RS20105	COG2169	Transcriptional regulator
P40_RS20160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P40_RS20165	COG4208	sulfate ABC transporter
P40_RS20175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
P40_RS20200	COG0840	transmembrane signaling receptor activity
P40_RS20210	COG2132	Multicopper oxidase
P40_RS20225	COG0288	reversible hydration of carbon dioxide
P40_RS20230	COG1047	Peptidyl-prolyl cis-trans
P40_RS20240	COG0583	DNA-binding transcription factor activity
P40_RS20265	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS20275	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS20280	COG1960	acyl-CoA dehydrogenase activity
P40_RS20285	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20295	COG2030	dehydratase
P40_RS20305	COG4191	Histidine kinase
P40_RS20310	COG4566	intracellular signal transduction
P40_RS20325	COG1959	2 iron, 2 sulfur cluster binding
P40_RS20335	COG1492	cobalamin metabolic process
P40_RS20345	COG1797	cobyrinic acid a,c-diamide synthase activity
P40_RS20350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
P40_RS20355	COG4139	cobalamin transport
P40_RS20360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
P40_RS20365	COG4206	TonB-dependent receptor
P40_RS20390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
P40_RS20395	COG3642	lipopolysaccharide core region biosynthetic process
P40_RS20405	COG0642	Histidine kinase
P40_RS20445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P40_RS20465	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
P40_RS20475	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20480	COG0583	DNA-binding transcription factor activity
P40_RS20485	COG0432	Pfam Uncharacterised protein family UPF0047
P40_RS20490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
P40_RS20500	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS20510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
P40_RS20520	COG1166	arginine decarboxylase activity
P40_RS20530	COG2814	Major facilitator Superfamily
P40_RS20540	COG4221	oxidoreductase activity
P40_RS20565	COG0004	ammonium transporteR
P40_RS20570	COG0347	Belongs to the P(II) protein family
P40_RS20575	COG2960	long-chain fatty acid transporting porin activity
P40_RS20580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
P40_RS20595	COG0697	spore germination
P40_RS20605	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20630	COG5002	protein histidine kinase activity
P40_RS20640	COG0745	RESPONSE REGULATOR receiver
P40_RS20660	COG1960	acyl-CoA dehydrogenase activity
P40_RS20665	COG1960	acyl-CoA dehydrogenase activity
P40_RS20680	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS20685	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS20700	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS20705	COG0183	Belongs to the thiolase family
P40_RS20715	COG2909	trisaccharide binding
P40_RS20725	COG1024	Enoyl-CoA hydratase
P40_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P40_RS20750	COG1024	Enoyl-CoA hydratase
P40_RS20755	COG1960	acyl-CoA dehydrogenase activity
P40_RS20770	COG1024	Enoyl-CoA hydratase
P40_RS20795	COG1280	lysine exporter protein (LysE YggA)
P40_RS20805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P40_RS20805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
P40_RS20840	COG1515	deoxyribonuclease V activity
P40_RS20895	COG2353	YceI-like domain
P40_RS20900	COG3038	cytochrome b561
P40_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS20915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P40_RS20920	COG0385	Bile acid
P40_RS20925	COG0492	ferredoxin-NADP+ reductase activity
P40_RS20940	COG1024	Enoyl-CoA hydratase
P40_RS20955	COG0517	IMP dehydrogenase activity
P40_RS20955	COG1125	glycine betaine transport
P40_RS20985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P40_RS20985	COG0678	peroxiredoxin activity
P40_RS21000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_RS21010	COG0753	catalase activity
P40_RS21015	COG1272	protein, Hemolysin III
P40_RS21025	COG0386	Belongs to the glutathione peroxidase family
P40_RS21055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
P40_RS21075	COG0348	domain, Protein
P40_RS21075	COG3901	Regulator of nitric oxide reductase transcription
P40_RS21100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
P40_RS21105	COG1320	monovalent cation:proton antiporter activity
P40_RS21110	COG2212	antiporter activity
P40_RS21115	COG1863	multisubunit Na H antiporter MnhE subunit
P40_RS21120	COG0651	ATP synthesis coupled electron transport
P40_RS21125	COG1006	Multisubunit Na H antiporter MnhC subunit
P40_RS21130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P40_RS21130	COG2111	Na H antiporter
P40_RS21145	COG1160	GTP binding
P40_RS21155	COG2610	gluconate transmembrane transporter activity
P40_RS21165	COG1960	acyl-CoA dehydrogenase activity
P40_RS21170	COG1250	3-hydroxyacyl-CoA dehydrogenase
P40_RS21170	COG1024	Enoyl-CoA hydratase
P40_RS21190	COG5285	phytanoyl-CoA dioxygenase
P40_RS21195	COG1028	Short-chain dehydrogenase reductase Sdr
P40_RS21240	COG1131	(ABC) transporter
P40_RS21245	COG0842	Transport permease protein
P40_RS21270	COG0625	glutathione transferase activity
P40_RS21275	COG0668	transmembrane transport
P40_RS21280	COG0678	peroxiredoxin activity
P40_RS21295	COG1666	GTP binding
P40_RS21305	COG3093	addiction module antidote protein HigA
P40_RS21310	COG1901	pseudouridine methyltransferase
P40_RS21320	COG0657	acetylesterase activity
P40_RS21340	COG1121	(ABC) transporter
P40_RS21345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P40_RS21350	COG0534	Mate efflux family protein
P40_RS21410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P40_RS21415	COG1773	rubredoxin
P40_RS21420	COG3161	chorismate lyase activity
P40_RS21425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P40_RS21440	COG2900	Belongs to the SlyX family
P40_RS21445	COG1309	transcriptional regulator
P40_RS21455	COG2119	membrane
P40_RS21460	COG4681	YaeQ
P40_RS21470	COG0431	NADPH-dependent FMN reductase
P40_RS21475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P40_RS21480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P40_RS21485	COG0640	Transcriptional regulator
P40_RS21495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P40_RS21500	COG0581	inorganic phosphate transmembrane transporter activity
P40_RS21505	COG0573	inorganic phosphate transmembrane transporter activity
P40_RS21510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P40_RS21530	COG1607	acyl-coa hydrolase
P40_RS21535	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
P40_RS21540	COG0210	DNA helicase
P40_RS21560	COG3284	Transcriptional regulator
P40_RS21575	COG1012	belongs to the aldehyde dehydrogenase family
P40_RS21610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P40_RS21615	COG0601	transmembrane transport
P40_RS21620	COG0747	negative chemotaxis
P40_RS21635	COG1960	acyl-CoA dehydrogenase activity
P40_RS21640	COG1309	transcriptional regulator
P40_RS21665	COG0824	Thioesterase
P40_RS21670	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS21675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P40_RS21680	COG1970	mechanosensitive ion channel activity
P40_RS21685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_RS21685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P40_RS21690	COG0737	Belongs to the 5'-nucleotidase family
P40_RS21700	COG0583	DNA-binding transcription factor activity
P40_RS21715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P40_RS21765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P40_RS21770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
P40_RS21775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
P40_RS21780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P40_RS21785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P40_RS21790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P40_RS21795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P40_RS21800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P40_RS21810	COG0356	it plays a direct role in the translocation of protons across the membrane
P40_RS21820	COG1475	DNA binding
P40_RS21825	COG1192	Involved in chromosome partitioning
P40_RS21830	COG0357	Ribosomal RNA small subunit methyltransferase G
P40_RS21835	COG0445	tRNA wobble uridine modification
P40_RS21845	COG0300	oxidoreductase activity
P40_RS21855	COG1960	acyl-CoA dehydrogenase activity
P40_RS21860	COG0546	phosphoglycolate phosphatase activity
P40_RS21870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P40_RS21875	COG1278	Cold shock
P40_RS21895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P40_RS21900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P40_RS21905	COG0318	PFAM AMP-dependent synthetase and ligase
P40_RS21925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P40_RS21930	COG0706	membrane insertase activity
P40_RS21935	COG0594	ribonuclease P activity
P40_RS21940	COG0230	Belongs to the bacterial ribosomal protein bL34 family