locus-tag	class	description
APS56_RS00025	COG0745	RESPONSE REGULATOR receiver
APS56_RS00025	COG2205	protein histidine kinase activity
APS56_RS00025	COG3292	Two component regulator propeller
APS56_RS00040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APS56_RS00050	COG0577	efflux transmembrane transporter activity
APS56_RS00050	COG1136	(ABC) transporter
APS56_RS00075	COG0335	large ribosomal subunit rRNA binding
APS56_RS00105	COG0069	glutamate synthase activity
APS56_RS00115	COG0210	DNA helicase
APS56_RS00135	COG0009	L-threonylcarbamoyladenylate synthase
APS56_RS00165	COG1288	antiporter activity
APS56_RS00170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APS56_RS00180	COG1575	Belongs to the MenA family. Type 1 subfamily
APS56_RS00185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
APS56_RS00190	COG4948	Mandelate Racemase Muconate Lactonizing
APS56_RS00195	COG1266	CAAX protease self-immunity
APS56_RS00205	COG0616	signal peptide processing
APS56_RS00215	COG1704	LemA family
APS56_RS00225	COG2814	Major facilitator Superfamily
APS56_RS00245	COG0513	Belongs to the DEAD box helicase family
APS56_RS00250	COG2339	peptidase activity
APS56_RS00255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APS56_RS00260	COG1363	Peptidase, m42
APS56_RS00270	COG1272	protein, Hemolysin III
APS56_RS00290	COG2226	methyltransferase
APS56_RS00295	COG0116	Belongs to the methyltransferase superfamily
APS56_RS00320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APS56_RS00325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APS56_RS00335	COG3237	CsbD-like
APS56_RS00360	COG0784	Response regulator, receiver
APS56_RS00365	COG4251	negative regulation of phosphorylation
APS56_RS00380	COG0784	Response regulator, receiver
APS56_RS00385	COG1764	response to oxidative stress
APS56_RS00395	COG0745	RESPONSE REGULATOR receiver
APS56_RS00395	COG2205	protein histidine kinase activity
APS56_RS00395	COG3292	Two component regulator propeller
APS56_RS00400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS56_RS00410	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS00415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS56_RS00430	COG2234	aminopeptidase activity
APS56_RS00450	COG0589	response to stress
APS56_RS00460	COG0592	DNA-directed DNA polymerase activity
APS56_RS00485	COG1702	phosphate starvation-inducible protein PhoH
APS56_RS00500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APS56_RS00520	COG1904	glucuronate isomerase
APS56_RS00525	COG0800	Aldolase
APS56_RS00540	COG1609	Transcriptional regulator
APS56_RS00545	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
APS56_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS00555	COG4677	pectinesterase activity
APS56_RS00560	COG1482	cell wall glycoprotein biosynthetic process
APS56_RS00565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APS56_RS00570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APS56_RS00580	COG1785	Belongs to the alkaline phosphatase family
APS56_RS00585	COG4771	TonB-dependent receptor
APS56_RS00610	COG0589	response to stress
APS56_RS00615	COG0745	RESPONSE REGULATOR receiver
APS56_RS00615	COG2205	protein histidine kinase activity
APS56_RS00615	COG3292	Two component regulator propeller
APS56_RS00620	COG2202	Pas domain
APS56_RS00620	COG1366	Belongs to the anti-sigma-factor antagonist family
APS56_RS00625	COG1289	transmembrane transporter activity
APS56_RS00635	COG3347	Dehydrogenase
APS56_RS00635	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS00640	COG4952	isomerase
APS56_RS00645	COG1070	Carbohydrate kinase
APS56_RS00650	COG0235	Class ii aldolase
APS56_RS00665	COG0490	domain, Protein
APS56_RS00665	COG2985	domain, Protein
APS56_RS00670	COG4771	TonB-dependent receptor
APS56_RS00690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS56_RS00695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APS56_RS00705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS56_RS00715	COG0673	inositol 2-dehydrogenase activity
APS56_RS00725	COG0012	GTP binding
APS56_RS00760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APS56_RS00765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS56_RS00790	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS56_RS00795	COG0673	inositol 2-dehydrogenase activity
APS56_RS00800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APS56_RS00810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APS56_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS56_RS00840	COG0513	Belongs to the DEAD box helicase family
APS56_RS00860	COG0037	tRNA processing
APS56_RS00865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APS56_RS00885	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APS56_RS00900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS56_RS00915	COG4585	Histidine kinase
APS56_RS00925	COG2223	nitrite transmembrane transporter activity
APS56_RS00930	COG0243	molybdopterin cofactor binding
APS56_RS00935	COG1773	rubredoxin
APS56_RS00945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS56_RS00960	COG4771	TonB-dependent receptor
APS56_RS01025	COG0738	Major facilitator superfamily
APS56_RS01035	COG2205	protein histidine kinase activity
APS56_RS01035	COG2202	Pas domain
APS56_RS01040	COG0784	Response regulator, receiver
APS56_RS01045	COG5002	protein histidine kinase activity
APS56_RS01060	COG0300	oxidoreductase activity
APS56_RS01070	COG0488	(ABC) transporter
APS56_RS01105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APS56_RS01135	COG2267	carboxylic ester hydrolase activity
APS56_RS01230	COG1408	metallophosphoesterase
APS56_RS01295	COG4974	Belongs to the 'phage' integrase family
APS56_RS01300	COG0336	Belongs to the RNA methyltransferase TrmD family
APS56_RS01335	COG3279	Response regulator of the LytR AlgR family
APS56_RS01345	COG1169	isochorismate synthase
APS56_RS01350	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APS56_RS01360	COG2996	Protein conserved in bacteria
APS56_RS01370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS56_RS01375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APS56_RS01385	COG4974	Belongs to the 'phage' integrase family
APS56_RS01465	COG2217	Heavy metal translocating P-type atpase
APS56_RS01475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS56_RS01495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS56_RS01540	COG0022	dehydrogenase e1 component
APS56_RS01550	COG1611	Belongs to the LOG family
APS56_RS01555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APS56_RS01585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APS56_RS01600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APS56_RS01610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APS56_RS01630	COG3279	Response regulator of the LytR AlgR family
APS56_RS01635	COG3275	phosphorelay sensor kinase activity
APS56_RS01645	COG0539	negative regulation of cytoplasmic translation
APS56_RS01650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APS56_RS01655	COG0540	Belongs to the ATCase OTCase family
APS56_RS01665	COG1234	tRNA 3'-trailer cleavage
APS56_RS01675	COG0259	pyridoxamine-phosphate oxidase activity
APS56_RS01690	COG2885	chlorophyll binding
APS56_RS01720	COG2885	chlorophyll binding
APS56_RS01745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APS56_RS01765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APS56_RS01770	COG1858	cytochrome C peroxidase
APS56_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APS56_RS01800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APS56_RS01810	COG1454	alcohol dehydrogenase
APS56_RS01830	COG1595	DNA-templated transcription, initiation
APS56_RS01840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APS56_RS01865	COG1360	Flagellar Motor Protein
APS56_RS01875	COG2814	Major facilitator Superfamily
APS56_RS01880	COG0668	transmembrane transport
APS56_RS01910	COG5434	Belongs to the glycosyl hydrolase 28 family
APS56_RS01915	COG0140	phosphoribosyl-ATP diphosphatase activity
APS56_RS01915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APS56_RS01920	COG0107	imidazoleglycerol-phosphate synthase activity
APS56_RS01925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APS56_RS01935	COG0131	Imidazoleglycerol-phosphate dehydratase
APS56_RS01940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APS56_RS01945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APS56_RS01950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APS56_RS01970	COG0612	Peptidase, M16
APS56_RS01985	COG1629	transport
APS56_RS01995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS56_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS02010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS56_RS02015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS56_RS02020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APS56_RS02025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS56_RS02030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APS56_RS02030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APS56_RS02035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS56_RS02040	COG1078	dGTPase activity
APS56_RS02045	COG2204	response regulator
APS56_RS02050	COG0802	atpase or kinase
APS56_RS02065	COG0686	Belongs to the AlaDH PNT family
APS56_RS02075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS56_RS02080	COG1086	Polysaccharide biosynthesis protein
APS56_RS02085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APS56_RS02095	COG4464	protein tyrosine phosphatase activity
APS56_RS02115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APS56_RS02120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS56_RS02125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APS56_RS02130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APS56_RS02145	COG0463	Glycosyl transferase, family 2
APS56_RS02175	COG1215	transferase activity, transferring glycosyl groups
APS56_RS02185	COG1216	Glycosyl transferase, family 2
APS56_RS02190	COG0438	transferase activity, transferring glycosyl groups
APS56_RS02225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS56_RS02230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS56_RS02255	COG1522	sequence-specific DNA binding
APS56_RS02280	COG0321	lipoyl(octanoyl) transferase activity
APS56_RS02280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APS56_RS02290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APS56_RS02295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APS56_RS02310	COG1012	belongs to the aldehyde dehydrogenase family
APS56_RS02320	COG1193	negative regulation of DNA recombination
APS56_RS02330	COG3011	Protein conserved in bacteria
APS56_RS02335	COG2897	thiosulfate sulfurtransferase activity
APS56_RS02340	COG1301	dicarboxylic acid transport
APS56_RS02345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APS56_RS02360	COG2076	Multidrug Resistance protein
APS56_RS02365	COG0247	lactate metabolic process
APS56_RS02365	COG0277	FAD linked oxidase domain protein
APS56_RS02380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APS56_RS02390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APS56_RS02395	COG0564	pseudouridine synthase activity
APS56_RS02400	COG1757	Na H antiporter
APS56_RS02405	COG0450	alkyl hydroperoxide reductase
APS56_RS02410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS56_RS02420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APS56_RS02425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APS56_RS02440	COG1674	ftsk spoiiie
APS56_RS02455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APS56_RS02455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APS56_RS02460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APS56_RS02480	COG4977	sequence-specific DNA binding
APS56_RS02480	COG1917	Cupin 2, conserved barrel domain protein
APS56_RS02515	COG2378	regulation of single-species biofilm formation
APS56_RS02565	COG0640	Transcriptional regulator
APS56_RS02590	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
APS56_RS02625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APS56_RS02645	COG0110	maltose O-acetyltransferase activity
APS56_RS02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS56_RS02670	COG2226	methyltransferase
APS56_RS02680	COG2223	nitrite transmembrane transporter activity
APS56_RS02695	COG1119	ATPase activity
APS56_RS02700	COG2223	nitrite transmembrane transporter activity
APS56_RS02820	COG0823	Involved in the tonB-independent uptake of proteins
APS56_RS02820	COG1506	peptidase
APS56_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS02860	COG1119	ATPase activity
APS56_RS02875	COG0205	6-phosphofructokinase activity
APS56_RS02885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APS56_RS02890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS56_RS02910	COG0628	permease
APS56_RS02920	COG3537	Alpha-1,2-mannosidase
APS56_RS02925	COG3507	Belongs to the glycosyl hydrolase 43 family
APS56_RS02930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APS56_RS02940	COG3119	arylsulfatase activity
APS56_RS02955	COG3537	Alpha-1,2-mannosidase
APS56_RS02960	COG3119	arylsulfatase activity
APS56_RS02965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APS56_RS02980	COG1472	Belongs to the glycosyl hydrolase 3 family
APS56_RS02985	COG3119	arylsulfatase activity
APS56_RS02990	COG3119	arylsulfatase activity
APS56_RS03000	COG3119	arylsulfatase activity
APS56_RS03005	COG3119	arylsulfatase activity
APS56_RS03010	COG3119	arylsulfatase activity
APS56_RS03015	COG1472	Belongs to the glycosyl hydrolase 3 family
APS56_RS03030	COG3119	arylsulfatase activity
APS56_RS03035	COG3119	arylsulfatase activity
APS56_RS03050	COG3537	Alpha-1,2-mannosidase
APS56_RS03055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APS56_RS03060	COG1446	asparaginase
APS56_RS03075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
APS56_RS03085	COG3537	Alpha-1,2-mannosidase
APS56_RS03095	COG3279	Response regulator of the LytR AlgR family
APS56_RS03100	COG0363	glucosamine-6-phosphate deaminase activity
APS56_RS03105	COG1629	transport
APS56_RS03110	COG0702	epimerase
APS56_RS03115	COG0101	tRNA pseudouridine synthase activity
APS56_RS03135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APS56_RS03140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APS56_RS03145	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
APS56_RS03155	COG0494	nUDIX hydrolase
APS56_RS03165	COG0488	(ABC) transporter
APS56_RS03185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APS56_RS03205	COG0066	3-isopropylmalate dehydratase activity
APS56_RS03210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APS56_RS03215	COG1607	acyl-coa hydrolase
APS56_RS03245	COG1480	7TM receptor with intracellular HD hydrolase
APS56_RS03250	COG0183	Belongs to the thiolase family
APS56_RS03255	COG0791	NLP P60 protein
APS56_RS03265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APS56_RS03270	COG0542	response to heat
APS56_RS03275	COG2270	Major facilitator Superfamily
APS56_RS03285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS56_RS03290	COG1252	NADH dehydrogenase
APS56_RS03295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS56_RS03305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APS56_RS03320	COG1418	mRNA catabolic process
APS56_RS03345	COG1104	cysteine desulfurase activity
APS56_RS03380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS56_RS03385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APS56_RS03400	COG3338	carbonate dehydratase activity
APS56_RS03405	COG0546	phosphoglycolate phosphatase activity
APS56_RS03410	COG2050	protein possibly involved in aromatic compounds catabolism
APS56_RS03410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APS56_RS03415	COG1309	transcriptional regulator
APS56_RS03430	COG1979	alcohol dehydrogenase
APS56_RS03440	COG1054	Belongs to the UPF0176 family
APS56_RS03455	COG3118	belongs to the thioredoxin family
APS56_RS03460	COG1271	oxidase subunit
APS56_RS03465	COG1294	oxidase, subunit
APS56_RS03495	COG2957	Belongs to the agmatine deiminase family
APS56_RS03500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS56_RS03520	COG1278	Cold shock
APS56_RS03530	COG0667	Aldo Keto reductase
APS56_RS03560	COG0813	purine-nucleoside phosphorylase activity
APS56_RS03570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APS56_RS03575	COG0460	homoserine dehydrogenase
APS56_RS03575	COG0527	aspartate kinase activity
APS56_RS03580	COG0083	homoserine kinase activity
APS56_RS03585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APS56_RS03590	COG0784	Response regulator, receiver
APS56_RS03590	COG2205	protein histidine kinase activity
APS56_RS03590	COG5002	protein histidine kinase activity
APS56_RS03595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APS56_RS03600	COG2066	Belongs to the glutaminase family
APS56_RS03610	COG2154	pterin-4-alpha-carbinolamine dehydratase
APS56_RS03615	COG0217	transcriptional regulatory protein
APS56_RS03625	COG0438	transferase activity, transferring glycosyl groups
APS56_RS03630	COG1472	Belongs to the glycosyl hydrolase 3 family
APS56_RS03640	COG2181	nitrate reductase activity
APS56_RS03640	COG0247	lactate metabolic process
APS56_RS03645	COG0247	lactate metabolic process
APS56_RS03645	COG2181	nitrate reductase activity
APS56_RS03650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APS56_RS03655	COG0860	N-Acetylmuramoyl-L-alanine amidase
APS56_RS03665	COG0251	oxidation-reduction process
APS56_RS03670	COG3850	Histidine kinase
APS56_RS03670	COG3437	response regulator, receiver
APS56_RS03670	COG2205	protein histidine kinase activity
APS56_RS03670	COG4999	Histidine kinase
APS56_RS03675	COG0516	GMP reductase activity
APS56_RS03690	COG2307	Protein conserved in bacteria
APS56_RS03690	COG2308	Evidence 4 Homologs of previously reported genes of
APS56_RS03700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APS56_RS03715	COG0542	response to heat
APS56_RS03730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APS56_RS03735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APS56_RS03745	COG0606	chelatase, subunit chli
APS56_RS03755	COG0303	'Molybdopterin
APS56_RS03770	COG0746	molybdenum cofactor guanylyltransferase activity
APS56_RS03780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APS56_RS03790	COG0315	cyclic pyranopterin monophosphate synthase activity
APS56_RS03790	COG0521	Mo-molybdopterin cofactor biosynthetic process
APS56_RS03795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APS56_RS03800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS03820	COG0798	PFAM Bile acid sodium symporter
APS56_RS03830	COG0302	gtp cyclohydrolase
APS56_RS03855	COG0359	binds to the 23S rRNA
APS56_RS03860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APS56_RS03865	COG0360	Binds together with S18 to 16S ribosomal RNA
APS56_RS03870	COG3279	Response regulator of the LytR AlgR family
APS56_RS03875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APS56_RS03900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APS56_RS03910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APS56_RS03915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APS56_RS03920	COG0735	belongs to the Fur family
APS56_RS03925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APS56_RS03940	COG4771	TonB-dependent receptor
APS56_RS03955	COG0584	glycerophosphoryl diester phosphodiesterase
APS56_RS03965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APS56_RS03985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APS56_RS03995	COG0561	phosphatase activity
APS56_RS04000	COG3956	TIGRFAM MazG family protein
APS56_RS04005	COG0561	phosphatase activity
APS56_RS04020	COG0305	Participates in initiation and elongation during chromosome replication
APS56_RS04025	COG0825	malonyl-CoA metabolic process
APS56_RS04040	COG0343	queuine tRNA-ribosyltransferase activity
APS56_RS04055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APS56_RS04060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APS56_RS04065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APS56_RS04130	COG1233	COG1233 Phytoene dehydrogenase and related
APS56_RS04150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS56_RS04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS56_RS04165	COG0242	peptide deformylase activity
APS56_RS04170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APS56_RS04215	COG0517	IMP dehydrogenase activity
APS56_RS04215	COG0617	tRNA 3'-terminal CCA addition
APS56_RS04215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APS56_RS04220	COG1612	heme a metabolic process
APS56_RS04250	COG0556	nucleotide-excision repair
APS56_RS04270	COG0045	succinate-CoA ligase (ADP-forming) activity
APS56_RS04275	COG0019	diaminopimelate decarboxylase activity
APS56_RS04300	COG2326	polyphosphate kinase activity
APS56_RS04305	COG2204	response regulator
APS56_RS04310	COG3264	Mechanosensitive ion channel
APS56_RS04310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APS56_RS04315	COG1668	transmembrane transport
APS56_RS04320	COG4152	abc transporter atp-binding protein
APS56_RS04325	COG0484	heat shock protein binding
APS56_RS04330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APS56_RS04355	COG0671	phosphoesterase, PA-phosphatase related
APS56_RS04365	COG0534	Mate efflux family protein
APS56_RS04380	COG0482	sulfurtransferase activity
APS56_RS04385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APS56_RS04395	COG0706	membrane insertase activity
APS56_RS04400	COG0504	CTP synthase activity
APS56_RS04405	COG3530	Putative quorum-sensing-regulated virulence factor
APS56_RS04415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APS56_RS04415	COG0519	Catalyzes the synthesis of GMP from XMP
APS56_RS04420	COG0076	glutamate decarboxylase activity
APS56_RS04425	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
APS56_RS04435	COG2258	MOSC domain
APS56_RS04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APS56_RS04475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APS56_RS04485	COG1522	sequence-specific DNA binding
APS56_RS04495	COG0788	formyltetrahydrofolate deformylase activity
APS56_RS04510	COG0284	orotidine-5'-phosphate decarboxylase activity
APS56_RS04515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APS56_RS04520	COG0516	GMP reductase activity
APS56_RS04520	COG0517	IMP dehydrogenase activity
APS56_RS04530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS56_RS04540	COG0167	dihydroorotate dehydrogenase activity
APS56_RS04545	COG2195	Cleaves the N-terminal amino acid of tripeptides
APS56_RS04550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APS56_RS04555	COG3119	arylsulfatase activity
APS56_RS04575	COG0702	epimerase
APS56_RS04580	COG4771	TonB-dependent receptor
APS56_RS04595	COG3119	arylsulfatase activity
APS56_RS04600	COG3119	arylsulfatase activity
APS56_RS04615	COG3119	arylsulfatase activity
APS56_RS04625	COG3119	arylsulfatase activity
APS56_RS04630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS04650	COG0702	epimerase
APS56_RS04655	COG4771	TonB-dependent receptor
APS56_RS04665	COG3292	Two component regulator propeller
APS56_RS04665	COG2205	protein histidine kinase activity
APS56_RS04665	COG0745	RESPONSE REGULATOR receiver
APS56_RS04735	COG2003	Belongs to the UPF0758 family
APS56_RS04740	COG0629	single-stranded DNA binding
APS56_RS04775	COG3940	Belongs to the glycosyl hydrolase 43 family
APS56_RS04800	COG0702	epimerase
APS56_RS04805	COG4771	TonB-dependent receptor
APS56_RS04815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APS56_RS04870	COG4974	Belongs to the 'phage' integrase family
APS56_RS04925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS56_RS04925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS56_RS04935	COG2264	protein methyltransferase activity
APS56_RS04945	COG0149	triose-phosphate isomerase activity
APS56_RS04950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS56_RS04955	COG0601	transmembrane transport
APS56_RS04970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APS56_RS04980	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APS56_RS04985	COG1132	(ABC) transporter
APS56_RS04990	COG0101	tRNA pseudouridine synthase activity
APS56_RS05005	COG1047	Peptidyl-prolyl cis-trans
APS56_RS05025	COG0124	histidyl-tRNA synthetase
APS56_RS05030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APS56_RS05035	COG0326	Molecular chaperone. Has ATPase activity
APS56_RS05060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APS56_RS05075	COG0174	glutamine synthetase
APS56_RS05080	COG1595	DNA-templated transcription, initiation
APS56_RS05115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APS56_RS05120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APS56_RS05135	COG1862	Preprotein translocase
APS56_RS05145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS56_RS05150	COG1132	(ABC) transporter
APS56_RS05160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS56_RS05170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APS56_RS05175	COG0514	ATP-dependent DNA helicase (RecQ)
APS56_RS05185	COG0805	protein transport
APS56_RS05190	COG1137	ATPase activity
APS56_RS05205	COG2354	Protein conserved in bacteria
APS56_RS05225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS56_RS05230	COG0297	glycogen (starch) synthase activity
APS56_RS05230	COG0438	transferase activity, transferring glycosyl groups
APS56_RS05280	COG2089	acid synthase
APS56_RS05285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APS56_RS05325	COG1216	Glycosyl transferase, family 2
APS56_RS05330	COG0438	transferase activity, transferring glycosyl groups
APS56_RS05340	COG0463	Glycosyl transferase, family 2
APS56_RS05340	COG1216	Glycosyl transferase, family 2
APS56_RS05345	COG0463	Glycosyl transferase, family 2
APS56_RS05350	COG1216	Glycosyl transferase, family 2
APS56_RS05350	COG0463	Glycosyl transferase, family 2
APS56_RS05360	COG2226	methyltransferase
APS56_RS05370	COG0110	maltose O-acetyltransferase activity
APS56_RS05395	COG0529	Catalyzes the synthesis of activated sulfate
APS56_RS05405	COG0489	protein tyrosine kinase activity
APS56_RS05415	COG0488	(ABC) transporter
APS56_RS05440	COG0653	protein targeting
APS56_RS05475	COG0513	Belongs to the DEAD box helicase family
APS56_RS05510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APS56_RS05515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APS56_RS05525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APS56_RS05530	COG0085	RNA polymerase activity
APS56_RS05535	COG0222	ribosome binding
APS56_RS05540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APS56_RS05545	COG0081	regulation of translation
APS56_RS05550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APS56_RS05570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APS56_RS05595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APS56_RS05600	COG4974	Belongs to the 'phage' integrase family
APS56_RS05605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS56_RS05615	COG1960	acyl-CoA dehydrogenase activity
APS56_RS05625	COG1115	amino acid carrier protein
APS56_RS05630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS56_RS05645	COG3119	arylsulfatase activity
APS56_RS05655	COG0339	signal peptide processing
APS56_RS05660	COG0071	Belongs to the small heat shock protein (HSP20) family
APS56_RS05700	COG3876	Protein conserved in bacteria
APS56_RS05715	COG3738	Protein conserved in bacteria
APS56_RS05730	COG2884	Cell division ATP-binding protein ftsE
APS56_RS05740	COG0463	Glycosyl transferase, family 2
APS56_RS05740	COG1216	Glycosyl transferase, family 2
APS56_RS05785	COG1217	gtp-binding protein TYPA
APS56_RS05795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APS56_RS05815	COG0300	oxidoreductase activity
APS56_RS05820	COG0366	Alpha amylase catalytic
APS56_RS05825	COG1595	DNA-templated transcription, initiation
APS56_RS05880	COG0738	Major facilitator superfamily
APS56_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS05895	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS56_RS05905	COG2721	sulfolactate sulfo-lyase activity
APS56_RS05910	COG3119	arylsulfatase activity
APS56_RS05915	COG1472	Belongs to the glycosyl hydrolase 3 family
APS56_RS05940	COG3119	arylsulfatase activity
APS56_RS05950	COG3119	arylsulfatase activity
APS56_RS05955	COG3693	PFAM glycoside hydrolase, family 10
APS56_RS05955	COG2382	esterase
APS56_RS05955	COG3507	Belongs to the glycosyl hydrolase 43 family
APS56_RS05980	COG3507	Belongs to the glycosyl hydrolase 43 family
APS56_RS06005	COG1501	Belongs to the glycosyl hydrolase 31 family
APS56_RS06010	COG3408	Glycogen debranching enzyme
APS56_RS06010	COG3119	arylsulfatase activity
APS56_RS06025	COG1472	Belongs to the glycosyl hydrolase 3 family
APS56_RS06090	COG3119	arylsulfatase activity
APS56_RS06105	COG1082	Xylose isomerase domain protein TIM barrel
APS56_RS06115	COG3119	arylsulfatase activity
APS56_RS06125	COG2814	Major facilitator Superfamily
APS56_RS06150	COG1629	transport
APS56_RS06175	COG4771	TonB-dependent receptor
APS56_RS06185	COG3292	Two component regulator propeller
APS56_RS06185	COG2205	protein histidine kinase activity
APS56_RS06185	COG0745	RESPONSE REGULATOR receiver
APS56_RS06195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS56_RS06205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APS56_RS06210	COG0247	lactate metabolic process
APS56_RS06215	COG1139	Iron-sulfur cluster binding protein
APS56_RS06220	COG1556	Lactate utilization protein
APS56_RS06240	COG0702	epimerase
APS56_RS06245	COG1629	transport
APS56_RS06265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APS56_RS06270	COG0745	RESPONSE REGULATOR receiver
APS56_RS06270	COG2205	protein histidine kinase activity
APS56_RS06270	COG3292	Two component regulator propeller
APS56_RS06290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APS56_RS06305	COG1609	Transcriptional regulator
APS56_RS06325	COG2059	Chromate
APS56_RS06335	COG0702	epimerase
APS56_RS06340	COG4771	TonB-dependent receptor
APS56_RS06355	COG1609	Transcriptional regulator
APS56_RS06380	COG0501	Belongs to the peptidase M48B family
APS56_RS06390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APS56_RS06410	COG2363	Small membrane protein
APS56_RS06415	COG1477	protein flavinylation
APS56_RS06440	COG4181	ATPase activity
APS56_RS06460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APS56_RS06465	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APS56_RS06470	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APS56_RS06475	COG1805	sodium ion transport
APS56_RS06490	COG2967	ApaG domain
APS56_RS06510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS56_RS06520	COG2373	Large extracellular alpha-helical protein
APS56_RS06545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS56_RS06550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APS56_RS06555	COG0563	adenylate kinase activity
APS56_RS06560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APS56_RS06565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APS56_RS06570	COG0339	signal peptide processing
APS56_RS06590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS56_RS06590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS56_RS06595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APS56_RS06655	COG3119	arylsulfatase activity
APS56_RS06665	COG1215	transferase activity, transferring glycosyl groups
APS56_RS06670	COG1215	transferase activity, transferring glycosyl groups
APS56_RS06685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APS56_RS06690	COG1127	ABC transporter
APS56_RS06715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS56_RS06720	COG4221	oxidoreductase activity
APS56_RS06730	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS56_RS06740	COG0295	cytidine deaminase activity
APS56_RS06760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APS56_RS06790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APS56_RS06810	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
APS56_RS06840	COG0640	Transcriptional regulator
APS56_RS06885	COG2378	regulation of single-species biofilm formation
APS56_RS06930	COG0640	Transcriptional regulator
APS56_RS06975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APS56_RS07000	COG3621	Patatin-like phospholipase
APS56_RS07005	COG0860	N-Acetylmuramoyl-L-alanine amidase
APS56_RS07085	COG2003	Belongs to the UPF0758 family
APS56_RS07090	COG0629	single-stranded DNA binding
APS56_RS07160	COG0488	(ABC) transporter
APS56_RS07170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS56_RS07170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APS56_RS07190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APS56_RS07200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APS56_RS07200	COG1754	DNA topoisomerase type I activity
APS56_RS07210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS56_RS07235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APS56_RS07240	COG0459	protein refolding
APS56_RS07265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APS56_RS07270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APS56_RS07295	COG1490	D-aminoacyl-tRNA deacylase activity
APS56_RS07300	COG1162	GTPase activity
APS56_RS07310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APS56_RS07315	COG0287	Prephenate dehydrogenase
APS56_RS07320	COG0436	Aminotransferase
APS56_RS07325	COG1605	Chorismate mutase
APS56_RS07325	COG0077	Prephenate dehydratase
APS56_RS07335	COG0857	belongs to the CobB CobQ family
APS56_RS07335	COG0280	phosphate acetyltransferase
APS56_RS07340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APS56_RS07355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APS56_RS07365	COG1410	methionine synthase
APS56_RS07365	COG0646	methionine synthase
APS56_RS07375	COG1045	serine acetyltransferase
APS56_RS07380	COG0492	ferredoxin-NADP+ reductase activity
APS56_RS07395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS56_RS07405	COG0175	sulfate reduction
APS56_RS07410	COG0175	sulfate reduction
APS56_RS07420	COG1959	2 iron, 2 sulfur cluster binding
APS56_RS07430	COG0460	homoserine dehydrogenase
APS56_RS07430	COG0527	aspartate kinase activity
APS56_RS07445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS56_RS07455	COG0657	acetylesterase activity
APS56_RS07455	COG2755	lipolytic protein G-D-S-L family
APS56_RS07465	COG0165	Argininosuccinate lyase
APS56_RS07475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APS56_RS07485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APS56_RS07495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APS56_RS07500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APS56_RS07505	COG0137	argininosuccinate synthase activity
APS56_RS07525	COG0673	inositol 2-dehydrogenase activity
APS56_RS07545	COG0673	inositol 2-dehydrogenase activity
APS56_RS07570	COG1187	pseudouridine synthase activity
APS56_RS07615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APS56_RS07645	COG0714	Associated with various cellular activities
APS56_RS07665	COG4774	siderophore transport
APS56_RS07675	COG0783	Belongs to the Dps family
APS56_RS07740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APS56_RS07740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS56_RS07765	COG2116	formate transmembrane transporter activity
APS56_RS07770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APS56_RS07785	COG1022	Amp-dependent synthetase and ligase
APS56_RS07790	COG1846	Transcriptional regulator
APS56_RS07795	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS56_RS07795	COG1024	Enoyl-CoA hydratase
APS56_RS07800	COG0183	Belongs to the thiolase family
APS56_RS07805	COG1960	acyl-CoA dehydrogenase activity
APS56_RS07825	COG0438	transferase activity, transferring glycosyl groups
APS56_RS07830	COG0561	phosphatase activity
APS56_RS07855	COG0745	RESPONSE REGULATOR receiver
APS56_RS07875	COG3278	Belongs to the heme-copper respiratory oxidase family
APS56_RS07890	COG0348	domain, Protein
APS56_RS07905	COG1085	galactose-1-phosphate uridylyltransferase
APS56_RS07910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APS56_RS07960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APS56_RS07990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APS56_RS08005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS56_RS08015	COG0463	Glycosyl transferase, family 2
APS56_RS08020	COG1215	transferase activity, transferring glycosyl groups
APS56_RS08025	COG1703	isobutyryl-CoA mutase activity
APS56_RS08030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS56_RS08030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS56_RS08035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS56_RS08040	COG0427	acetyl-CoA hydrolase
APS56_RS08050	COG0511	ligase activity, forming carbon-carbon bonds
APS56_RS08060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APS56_RS08065	COG0346	lactoylglutathione lyase activity
APS56_RS08090	COG0010	Belongs to the arginase family
APS56_RS08095	COG1166	arginine decarboxylase activity
APS56_RS08100	COG0084	hydrolase, TatD family'
APS56_RS08105	COG0252	asparaginase activity
APS56_RS08115	COG0811	peptide transport
APS56_RS08145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APS56_RS08150	COG0017	Asparaginyl-tRNA synthetase
APS56_RS08165	COG0233	cytoplasmic translational termination
APS56_RS08170	COG0528	UMP kinase activity
APS56_RS08175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APS56_RS08180	COG0052	Belongs to the universal ribosomal protein uS2 family
APS56_RS08185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APS56_RS08190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APS56_RS08195	COG0772	Belongs to the SEDS family
APS56_RS08200	COG0768	penicillin binding
APS56_RS08215	COG1077	Cell shape determining protein MreB Mrl
APS56_RS08225	COG2205	protein histidine kinase activity
APS56_RS08235	COG0138	bifunctional purine biosynthesis protein purh
APS56_RS08255	COG2217	Heavy metal translocating P-type atpase
APS56_RS08275	COG0357	Ribosomal RNA small subunit methyltransferase G
APS56_RS08280	COG3239	Fatty acid desaturase
APS56_RS08285	COG0436	Aminotransferase
APS56_RS08290	COG0783	Belongs to the Dps family
APS56_RS08315	COG4251	negative regulation of phosphorylation
APS56_RS08390	COG1428	Deoxynucleoside kinase
APS56_RS08400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
APS56_RS08405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APS56_RS08415	COG0517	IMP dehydrogenase activity
APS56_RS08435	COG1610	YqeY-like protein
APS56_RS08440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APS56_RS08455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS56_RS08460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APS56_RS08465	COG0772	Belongs to the SEDS family
APS56_RS08470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APS56_RS08475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APS56_RS08480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS56_RS08485	COG0768	penicillin binding
APS56_RS08495	COG0275	rRNA processing
APS56_RS08500	COG2001	Belongs to the MraZ family
APS56_RS08505	COG2267	carboxylic ester hydrolase activity
APS56_RS08510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APS56_RS08515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS56_RS08525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APS56_RS08535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS56_RS08540	COG0791	NLP P60 protein
APS56_RS08545	COG0658	competence protein
APS56_RS08545	COG2333	competence protein COMEC
APS56_RS08550	COG4232	protein-disulfide reductase activity
APS56_RS08560	COG3104	oligopeptide transport
APS56_RS08565	COG1506	peptidase
APS56_RS08565	COG0823	Involved in the tonB-independent uptake of proteins
APS56_RS08580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS56_RS08585	COG1253	flavin adenine dinucleotide binding
APS56_RS08610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APS56_RS08685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APS56_RS08720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS56_RS08725	COG2032	superoxide dismutase activity
APS56_RS08740	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
APS56_RS08745	COG1012	belongs to the aldehyde dehydrogenase family
APS56_RS08750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APS56_RS08755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APS56_RS08765	COG0028	Belongs to the TPP enzyme family
APS56_RS08770	COG0129	dihydroxy-acid dehydratase activity
APS56_RS08775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APS56_RS08785	COG1132	(ABC) transporter
APS56_RS08795	COG0297	glycogen (starch) synthase activity
APS56_RS08805	COG0022	dehydrogenase e1 component
APS56_RS08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS56_RS08810	COG2086	electron transfer activity
APS56_RS08815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APS56_RS08825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APS56_RS08830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APS56_RS08835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS56_RS08850	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS08865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APS56_RS08870	COG0110	maltose O-acetyltransferase activity
APS56_RS08885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APS56_RS08890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APS56_RS08895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APS56_RS08915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APS56_RS08920	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APS56_RS08935	COG4771	TonB-dependent receptor
APS56_RS08960	COG0405	Gamma-glutamyltransferase
APS56_RS08970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS56_RS08985	COG1733	regulation of RNA biosynthetic process
APS56_RS09010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS56_RS09015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS56_RS09025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APS56_RS09045	COG1946	Acyl-CoA thioesterase
APS56_RS09055	COG2081	HI0933 family
APS56_RS09075	COG1696	Membrane protein involved in D-alanine export
APS56_RS09090	COG1187	pseudouridine synthase activity
APS56_RS09130	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS56_RS09135	COG0567	Dehydrogenase, E1 component
APS56_RS09145	COG1959	2 iron, 2 sulfur cluster binding
APS56_RS09155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APS56_RS09160	COG4263	nitrous-oxide reductase activity
APS56_RS09210	COG1309	transcriptional regulator
APS56_RS09230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS56_RS09240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APS56_RS09265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APS56_RS09270	COG0300	oxidoreductase activity
APS56_RS09275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APS56_RS09290	COG0659	secondary active sulfate transmembrane transporter activity
APS56_RS09300	COG1629	transport
APS56_RS09300	COG4206	TonB-dependent receptor
APS56_RS09310	COG1629	transport
APS56_RS09315	COG0629	single-stranded DNA binding
APS56_RS09325	COG0516	GMP reductase activity
APS56_RS09325	COG0517	IMP dehydrogenase activity
APS56_RS09345	COG3123	guanosine phosphorylase activity
APS56_RS09360	COG2207	Transcriptional regulator
APS56_RS09360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APS56_RS09375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APS56_RS09375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APS56_RS09390	COG2095	MarC family integral membrane protein
APS56_RS09410	COG0793	Belongs to the peptidase S41A family
APS56_RS09435	COG0067	glutamate synthase
APS56_RS09435	COG0069	glutamate synthase activity
APS56_RS09435	COG0070	glutamate synthase
APS56_RS09445	COG0004	ammonium transporteR
APS56_RS09450	COG0347	Belongs to the P(II) protein family
APS56_RS09455	COG0004	ammonium transporteR
APS56_RS09460	COG0347	Belongs to the P(II) protein family
APS56_RS09465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APS56_RS09475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APS56_RS09480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APS56_RS09495	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APS56_RS09505	COG0460	homoserine dehydrogenase
APS56_RS09505	COG0527	aspartate kinase activity
APS56_RS09515	COG3152	Membrane
APS56_RS09530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS56_RS09550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APS56_RS09550	COG0515	serine threonine protein kinase
APS56_RS09560	COG2239	Acts as a magnesium transporter
APS56_RS09565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APS56_RS09585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APS56_RS09595	COG0196	riboflavin kinase activity
APS56_RS09605	COG0193	aminoacyl-tRNA hydrolase activity
APS56_RS09610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APS56_RS09615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APS56_RS09640	COG4771	TonB-dependent receptor
APS56_RS09675	COG3119	arylsulfatase activity
APS56_RS09685	COG3119	arylsulfatase activity
APS56_RS09710	COG3119	arylsulfatase activity
APS56_RS09715	COG3119	arylsulfatase activity
APS56_RS09720	COG3119	arylsulfatase activity
APS56_RS09725	COG3119	arylsulfatase activity
APS56_RS09735	COG3119	arylsulfatase activity
APS56_RS09750	COG0657	acetylesterase activity
APS56_RS09750	COG2755	lipolytic protein G-D-S-L family
APS56_RS09755	COG3119	arylsulfatase activity
APS56_RS09765	COG3119	arylsulfatase activity
APS56_RS09780	COG3119	arylsulfatase activity
APS56_RS09785	COG3119	arylsulfatase activity
APS56_RS09810	COG3119	arylsulfatase activity
APS56_RS09815	COG3119	arylsulfatase activity
APS56_RS09825	COG3119	arylsulfatase activity
APS56_RS09840	COG4771	TonB-dependent receptor
APS56_RS09865	COG3250	beta-galactosidase activity
APS56_RS09895	COG3119	arylsulfatase activity
APS56_RS09900	COG3119	arylsulfatase activity
APS56_RS09925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APS56_RS09930	COG3119	arylsulfatase activity
APS56_RS09935	COG3119	arylsulfatase activity
APS56_RS09945	COG4771	TonB-dependent receptor
APS56_RS09970	COG0702	epimerase
APS56_RS09975	COG4771	TonB-dependent receptor
APS56_RS09980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS09985	COG0745	RESPONSE REGULATOR receiver
APS56_RS09985	COG3292	Two component regulator propeller
APS56_RS09985	COG2205	protein histidine kinase activity
APS56_RS09995	COG0471	metal ion transport
APS56_RS09995	COG3273	potassium ion transport
APS56_RS10005	COG0194	GDP metabolic process
APS56_RS10010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APS56_RS10030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APS56_RS10040	COG3655	Transcriptional regulator
APS56_RS10050	COG0745	RESPONSE REGULATOR receiver
APS56_RS10050	COG2205	protein histidine kinase activity
APS56_RS10050	COG3292	Two component regulator propeller
APS56_RS10055	COG2755	lipolytic protein G-D-S-L family
APS56_RS10055	COG0657	acetylesterase activity
APS56_RS10080	COG0561	phosphatase activity
APS56_RS10085	COG4771	TonB-dependent receptor
APS56_RS10095	COG0673	inositol 2-dehydrogenase activity
APS56_RS10100	COG0673	inositol 2-dehydrogenase activity
APS56_RS10105	COG3119	arylsulfatase activity
APS56_RS10105	COG3408	Glycogen debranching enzyme
APS56_RS10110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APS56_RS10125	COG1381	Involved in DNA repair and RecF pathway recombination
APS56_RS10135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APS56_RS10180	COG1999	signal sequence binding
APS56_RS10210	COG0803	Belongs to the bacterial solute-binding protein 9 family
APS56_RS10215	COG1121	(ABC) transporter
APS56_RS10220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS56_RS10225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS56_RS10230	COG0792	nuclease activity
APS56_RS10245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APS56_RS10270	COG2183	response to ionizing radiation
APS56_RS10285	COG1528	Iron-storage protein
APS56_RS10290	COG3015	lipoprotein NlpE involved in copper resistance
APS56_RS10295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS56_RS10295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS56_RS10300	COG1619	proteins homologs of microcin C7 resistance protein MccF
APS56_RS10330	COG0484	heat shock protein binding
APS56_RS10355	COG1418	mRNA catabolic process
APS56_RS10405	COG1858	cytochrome C peroxidase
APS56_RS10425	COG1024	Enoyl-CoA hydratase
APS56_RS10430	COG5000	phosphorelay sensor kinase activity
APS56_RS10435	COG1981	membrane
APS56_RS10445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APS56_RS10460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APS56_RS10465	COG0181	hydroxymethylbilane synthase activity
APS56_RS10470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APS56_RS10480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APS56_RS10485	COG0408	coproporphyrinogen oxidase activity
APS56_RS10490	COG0556	nucleotide-excision repair
APS56_RS10495	COG3012	SEC-C Motif Domain Protein
APS56_RS10500	COG0113	porphobilinogen synthase activity
APS56_RS10505	COG1253	flavin adenine dinucleotide binding
APS56_RS10540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APS56_RS10550	COG1774	PSP1 C-terminal conserved region
APS56_RS10560	COG0826	peptidase U32
APS56_RS10570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APS56_RS10600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APS56_RS10600	COG0758	DNA mediated transformation
APS56_RS10640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APS56_RS10645	COG0756	dUTP diphosphatase activity
APS56_RS10655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APS56_RS10660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APS56_RS10665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APS56_RS10670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APS56_RS10675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APS56_RS10680	COG0356	it plays a direct role in the translocation of protons across the membrane
APS56_RS10705	COG0859	PFAM glycosyl transferase family 9
APS56_RS10715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APS56_RS10730	COG0151	Belongs to the GarS family
APS56_RS10740	COG0463	Glycosyl transferase, family 2
APS56_RS10760	COG0535	radical SAM domain protein
APS56_RS10765	COG0438	transferase activity, transferring glycosyl groups
APS56_RS10765	COG0297	glycogen (starch) synthase activity
APS56_RS10775	COG3458	cephalosporin-C deacetylase activity
APS56_RS10805	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APS56_RS10810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APS56_RS10855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS56_RS10865	COG0791	NLP P60 protein
APS56_RS10865	COG1388	LysM domain
APS56_RS10870	COG0126	phosphoglycerate kinase activity
APS56_RS10875	COG0470	DNA polymerase III
APS56_RS10895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS56_RS10900	COG0445	tRNA wobble uridine modification
APS56_RS10905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APS56_RS10915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS56_RS10930	COG0594	ribonuclease P activity
APS56_RS10940	COG0793	Belongs to the peptidase S41A family
APS56_RS10955	COG2153	protein acetylation
APS56_RS10965	COG0698	ribose 5-phosphate isomerase
APS56_RS10980	COG0557	exoribonuclease II activity
APS56_RS11015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APS56_RS11020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS56_RS11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS56_RS11075	COG3263	regulation of cellular component size
APS56_RS11090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS56_RS11095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APS56_RS11100	COG0297	glycogen (starch) synthase activity
APS56_RS11105	COG0481	GTPase activity
APS56_RS11130	COG4591	ABC-type transport system involved in lipoprotein release permease component
APS56_RS11135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APS56_RS11145	COG2723	6-phospho-beta-galactosidase activity
APS56_RS11170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APS56_RS11180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APS56_RS11185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APS56_RS11190	COG0511	ligase activity, forming carbon-carbon bonds
APS56_RS11195	COG0439	Biotin carboxylase
APS56_RS11200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS56_RS11230	COG1505	serine-type exopeptidase activity
APS56_RS11235	COG2234	aminopeptidase activity
APS56_RS11240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APS56_RS11245	COG1970	mechanosensitive ion channel activity
APS56_RS11250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APS56_RS11255	COG1435	thymidine kinase activity
APS56_RS11265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS56_RS11275	COG1573	uracil-dna glycosylase
APS56_RS11285	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APS56_RS11285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APS56_RS11300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS56_RS11310	COG0720	synthase
APS56_RS11330	COG3250	beta-galactosidase activity
APS56_RS11340	COG0702	epimerase
APS56_RS11345	COG4771	TonB-dependent receptor
APS56_RS11355	COG2205	protein histidine kinase activity
APS56_RS11355	COG3292	Two component regulator propeller
APS56_RS11355	COG0745	RESPONSE REGULATOR receiver
APS56_RS11375	COG1074	ATP-dependent DNA helicase activity
APS56_RS11390	COG0351	phosphomethylpyrimidine kinase
APS56_RS11390	COG0352	thiamine-phosphate diphosphorylase activity
APS56_RS11405	COG0328	RNA-DNA hybrid ribonuclease activity
APS56_RS11405	COG3341	Caulimovirus viroplasmin
APS56_RS11410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APS56_RS11415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APS56_RS11420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS56_RS11425	COG0571	ribonuclease III activity
APS56_RS11435	COG0469	pyruvate kinase activity
APS56_RS11450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APS56_RS11455	COG2954	triphosphatase activity
APS56_RS11470	COG4953	penicillin-binding protein 1C
APS56_RS11480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APS56_RS11505	COG0714	Associated with various cellular activities
APS56_RS11520	COG2304	oxidoreductase activity
APS56_RS11525	COG2304	oxidoreductase activity
APS56_RS11545	COG0288	reversible hydration of carbon dioxide
APS56_RS11560	COG4206	TonB-dependent receptor
APS56_RS11605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APS56_RS11615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS56_RS11625	COG1538	Outer membrane efflux protein
APS56_RS11655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APS56_RS11660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APS56_RS11685	COG2137	regulation of response to DNA damage stimulus
APS56_RS11710	COG0667	Aldo Keto reductase
APS56_RS11715	COG1360	Flagellar Motor Protein
APS56_RS11720	COG0708	Exodeoxyribonuclease III
APS56_RS11730	COG2234	aminopeptidase activity
APS56_RS11730	COG4935	Belongs to the peptidase S8 family
APS56_RS11735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APS56_RS11740	COG1053	succinate dehydrogenase
APS56_RS11755	COG0006	proline dipeptidase activity
APS56_RS11760	COG0527	aspartate kinase activity
APS56_RS11800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APS56_RS11810	COG0316	Belongs to the HesB IscA family
APS56_RS11815	COG0719	Fe-S assembly protein
APS56_RS11825	COG0396	ATPase activity
APS56_RS11830	COG0719	Fe-S assembly protein
APS56_RS11835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APS56_RS11840	COG2166	iron-sulfur cluster assembly
APS56_RS11845	COG2151	metal-sulfur cluster biosynthetic enzyme
APS56_RS11870	COG1530	ribonuclease E activity
APS56_RS11875	COG0776	regulation of translation
APS56_RS11880	COG1194	a g-specific adenine glycosylase
APS56_RS11900	COG2608	mercury ion transmembrane transporter activity
APS56_RS11910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APS56_RS11915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APS56_RS11940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APS56_RS11950	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
APS56_RS11960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APS56_RS12020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APS56_RS12035	COG1629	transport
APS56_RS12035	COG4206	TonB-dependent receptor
APS56_RS12040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APS56_RS12050	COG0297	glycogen (starch) synthase activity
APS56_RS12055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APS56_RS12060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APS56_RS12075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APS56_RS12090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APS56_RS12100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APS56_RS12110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APS56_RS12120	COG0189	ligase activity
APS56_RS12125	COG0189	ligase activity
APS56_RS12125	COG4067	protein conserved in archaea
APS56_RS12130	COG0322	excinuclease ABC activity
APS56_RS12135	COG1752	Esterase of the alpha-beta hydrolase superfamily
APS56_RS12145	COG3483	tryptophan 2,3-dioxygenase activity
APS56_RS12155	COG0166	Belongs to the GPI family
APS56_RS12175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS56_RS12190	COG3852	Histidine kinase
APS56_RS12200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APS56_RS12210	COG0519	Catalyzes the synthesis of GMP from XMP
APS56_RS12225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APS56_RS12230	COG1968	undecaprenyl-diphosphatase activity
APS56_RS12235	COG1929	Belongs to the glycerate kinase type-1 family
APS56_RS12245	COG2177	Part of the ABC transporter FtsEX involved in
APS56_RS12250	COG0697	spore germination
APS56_RS12255	COG0495	leucyl-tRNA aminoacylation
APS56_RS12265	COG0686	Belongs to the AlaDH PNT family
APS56_RS12275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APS56_RS12305	COG0423	glycine-tRNA ligase activity
APS56_RS12310	COG1522	sequence-specific DNA binding
APS56_RS12315	COG2363	Small membrane protein
APS56_RS12330	COG0463	Glycosyl transferase, family 2
APS56_RS12335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS56_RS12350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APS56_RS12365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APS56_RS12390	COG2115	Belongs to the xylose isomerase family
APS56_RS12395	COG0477	Major facilitator Superfamily
APS56_RS12395	COG2814	Major facilitator Superfamily
APS56_RS12405	COG0745	RESPONSE REGULATOR receiver
APS56_RS12410	COG5002	protein histidine kinase activity
APS56_RS12420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APS56_RS12435	COG0133	tryptophan synthase activity
APS56_RS12440	COG0489	protein tyrosine kinase activity
APS56_RS12455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APS56_RS12455	COG1013	pyruvate-flavodoxin oxidoreductase activity
APS56_RS12455	COG0674	pyruvate-flavodoxin oxidoreductase activity
APS56_RS12455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APS56_RS12460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APS56_RS12465	COG4657	Part of a membrane complex involved in electron transport
APS56_RS12470	COG4660	Part of a membrane complex involved in electron transport
APS56_RS12475	COG4659	FMN binding
APS56_RS12480	COG4658	electron transport chain
APS56_RS12485	COG4656	Part of a membrane complex involved in electron transport
APS56_RS12490	COG1245	4Fe-4S binding domain
APS56_RS12490	COG2878	Part of a membrane complex involved in electron transport
APS56_RS12500	COG0633	Ferredoxin
APS56_RS12530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APS56_RS12540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APS56_RS12545	COG0228	four-way junction DNA binding
APS56_RS12550	COG2706	6-phosphogluconolactonase activity
APS56_RS12570	COG3279	Response regulator of the LytR AlgR family
APS56_RS12575	COG3275	phosphorelay sensor kinase activity
APS56_RS12585	COG1136	(ABC) transporter
APS56_RS12585	COG0577	efflux transmembrane transporter activity
APS56_RS12590	COG1136	(ABC) transporter
APS56_RS12595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS56_RS12600	COG1538	Outer membrane efflux protein
APS56_RS12610	COG0740	serine-type endopeptidase activity
APS56_RS12625	COG1904	glucuronate isomerase
APS56_RS12630	COG0246	Mannitol dehydrogenase
APS56_RS12635	COG2721	sulfolactate sulfo-lyase activity
APS56_RS12650	COG2755	lipolytic protein G-D-S-L family
APS56_RS12655	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS12695	COG2755	lipolytic protein G-D-S-L family
APS56_RS12695	COG0657	acetylesterase activity
APS56_RS12710	COG0702	epimerase
APS56_RS12715	COG4771	TonB-dependent receptor
APS56_RS12720	COG2755	lipolytic protein G-D-S-L family
APS56_RS12740	COG0673	inositol 2-dehydrogenase activity
APS56_RS12750	COG4585	Histidine kinase
APS56_RS12755	COG2197	response regulator
APS56_RS12760	COG2839	Protein conserved in bacteria
APS56_RS12770	COG0463	Glycosyl transferase, family 2
APS56_RS12785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APS56_RS12790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS56_RS12795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APS56_RS12805	COG2315	Protein conserved in bacteria
APS56_RS12815	COG2824	Alkylphosphonate utilization operon protein PhnA
APS56_RS12830	COG0697	spore germination
APS56_RS12870	COG1785	Belongs to the alkaline phosphatase family
APS56_RS12875	COG0589	response to stress
APS56_RS12880	COG0779	Required for maturation of 30S ribosomal subunits
APS56_RS12885	COG0195	Participates in both transcription termination and antitermination
APS56_RS12885	COG2251	uridine kinase activity
APS56_RS12890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APS56_RS12905	COG0437	4 iron, 4 sulfur cluster binding
APS56_RS12930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS56_RS12935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS56_RS12950	COG2885	chlorophyll binding
APS56_RS12955	COG2255	four-way junction helicase activity
APS56_RS12960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APS56_RS12970	COG5002	protein histidine kinase activity
APS56_RS12980	COG0632	four-way junction helicase activity
APS56_RS12990	COG0509	glycine decarboxylation via glycine cleavage system
APS56_RS13015	COG0109	protoheme IX farnesyltransferase activity
APS56_RS13020	COG1845	cytochrome c oxidase, subunit III
APS56_RS13025	COG1845	cytochrome c oxidase, subunit III
APS56_RS13040	COG1999	signal sequence binding
APS56_RS13045	COG2322	membrane
APS56_RS13055	COG1136	(ABC) transporter
APS56_RS13060	COG1136	(ABC) transporter
APS56_RS13060	COG0577	efflux transmembrane transporter activity
APS56_RS13065	COG0577	efflux transmembrane transporter activity
APS56_RS13065	COG1136	(ABC) transporter
APS56_RS13070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS56_RS13075	COG1538	Outer membrane efflux protein
APS56_RS13080	COG1214	PFAM Peptidase M22, glycoprotease
APS56_RS13085	COG0668	transmembrane transport
APS56_RS13090	COG3759	membrane
APS56_RS13095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APS56_RS13105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APS56_RS13110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APS56_RS13125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS56_RS13130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APS56_RS13140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APS56_RS13150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APS56_RS13155	COG0596	Alpha beta hydrolase
APS56_RS13165	COG0544	peptidyl-prolyl cis-trans isomerase activity
APS56_RS13175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APS56_RS13190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS56_RS13195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS56_RS13215	COG1428	Deoxynucleoside kinase
APS56_RS13235	COG3263	regulation of cellular component size
APS56_RS13260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APS56_RS13275	COG3118	belongs to the thioredoxin family
APS56_RS13280	COG1408	metallophosphoesterase
APS56_RS13295	COG2197	response regulator
APS56_RS13310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APS56_RS13310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APS56_RS13320	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
APS56_RS13325	COG1032	radical SAM domain protein
APS56_RS13330	COG4680	protein conserved in bacteria
APS56_RS13360	COG1733	regulation of RNA biosynthetic process
APS56_RS13380	COG0697	spore germination
APS56_RS13405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APS56_RS13410	COG2197	response regulator
APS56_RS13415	COG0358	DNA primase activity
APS56_RS13420	COG2308	Evidence 4 Homologs of previously reported genes of
APS56_RS13440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APS56_RS13450	COG1160	GTP binding
APS56_RS13470	COG1704	LemA family
APS56_RS13485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APS56_RS13530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APS56_RS13535	COG1629	transport
APS56_RS13535	COG4206	TonB-dependent receptor
APS56_RS13590	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
APS56_RS13610	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APS56_RS13615	COG0791	NLP P60 protein
APS56_RS13615	COG1388	LysM domain
APS56_RS13620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APS56_RS13640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APS56_RS13645	COG0321	lipoyl(octanoyl) transferase activity
APS56_RS13670	COG1609	Transcriptional regulator
APS56_RS13690	COG0363	glucosamine-6-phosphate deaminase activity
APS56_RS13700	COG3119	arylsulfatase activity
APS56_RS13710	COG0745	RESPONSE REGULATOR receiver
APS56_RS13710	COG2205	protein histidine kinase activity
APS56_RS13710	COG3292	Two component regulator propeller
APS56_RS13715	COG5492	domain, Protein
APS56_RS13720	COG4771	TonB-dependent receptor
APS56_RS13730	COG1629	transport
APS56_RS13735	COG0702	epimerase
APS56_RS13745	COG5492	domain, Protein
APS56_RS13750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
APS56_RS13755	COG3250	beta-galactosidase activity
APS56_RS13760	COG3250	beta-galactosidase activity
APS56_RS13770	COG1960	acyl-CoA dehydrogenase activity
APS56_RS13775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APS56_RS13785	COG0848	biopolymer transport protein
APS56_RS13795	COG0285	dihydrofolate synthase activity
APS56_RS13805	COG3340	Belongs to the peptidase S51 family
APS56_RS13840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APS56_RS13860	COG2003	Belongs to the UPF0758 family
APS56_RS13870	COG1011	Hydrolase
APS56_RS13890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APS56_RS13900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS56_RS13915	COG1629	transport
APS56_RS13925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APS56_RS13930	COG0049	tRNA binding
APS56_RS13935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APS56_RS13940	COG0051	transcription antitermination factor activity, RNA binding
APS56_RS13945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APS56_RS13950	COG0088	Forms part of the polypeptide exit tunnel
APS56_RS13955	COG0089	rRNA binding
APS56_RS13960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APS56_RS13965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APS56_RS13970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APS56_RS13975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APS56_RS13980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APS56_RS13985	COG0255	Belongs to the universal ribosomal protein uL29 family
APS56_RS13990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APS56_RS13995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APS56_RS14000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APS56_RS14005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APS56_RS14010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APS56_RS14015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APS56_RS14020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APS56_RS14025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APS56_RS14030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APS56_RS14035	COG1841	ribosomal large subunit assembly
APS56_RS14040	COG0200	Binds to the 23S rRNA
APS56_RS14045	COG0201	protein transport
APS56_RS14050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APS56_RS14055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APS56_RS14060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APS56_RS14065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APS56_RS14070	COG0202	RNA polymerase activity
APS56_RS14075	COG0203	ribosomal protein L17
APS56_RS14080	COG0505	Belongs to the CarA family
APS56_RS14085	COG0148	phosphopyruvate hydratase activity
APS56_RS14105	COG0688	phosphatidylethanolamine metabolic process
APS56_RS14110	COG4589	Belongs to the CDS family
APS56_RS14120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APS56_RS14125	COG0799	negative regulation of ribosome biogenesis
APS56_RS14130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APS56_RS14130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APS56_RS14140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APS56_RS14165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APS56_RS14170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APS56_RS14175	COG1187	pseudouridine synthase activity
APS56_RS14185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APS56_RS14195	COG0433	COG0433 Predicted ATPase
APS56_RS14200	COG0602	queuosine metabolic process
APS56_RS14230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APS56_RS14235	COG0154	amidase activity
APS56_RS14250	COG0187	DNA topoisomerase II activity
APS56_RS14255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS56_RS14265	COG0662	Cupin 2, conserved barrel domain protein
APS56_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS14275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS56_RS14280	COG3844	kynureninase activity
APS56_RS14285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APS56_RS14290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS56_RS14300	COG1185	polyribonucleotide nucleotidyltransferase activity
APS56_RS14305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APS56_RS14315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APS56_RS14320	COG0191	fructose-bisphosphate aldolase activity
APS56_RS14330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS56_RS14340	COG2226	methyltransferase
APS56_RS14345	COG0569	domain protein
APS56_RS14355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APS56_RS14380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APS56_RS14385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APS56_RS14395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APS56_RS14400	COG0105	UTP biosynthetic process
APS56_RS14405	COG1278	Cold shock
APS56_RS14425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APS56_RS14435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APS56_RS14450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APS56_RS14480	COG0681	Belongs to the peptidase S26 family
APS56_RS14485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APS56_RS14495	COG1475	DNA binding
APS56_RS14500	COG1192	Involved in chromosome partitioning
APS56_RS14530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS56_RS14540	COG0572	uridine kinase
APS56_RS14550	COG2133	pyrroloquinoline quinone binding
APS56_RS14565	COG2169	Transcriptional regulator
APS56_RS14570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS56_RS14590	COG1309	transcriptional regulator
APS56_RS14605	COG4771	TonB-dependent receptor
APS56_RS14610	COG0702	epimerase
APS56_RS14705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APS56_RS14710	COG1663	tetraacyldisaccharide 4'-kinase activity
APS56_RS14715	COG2205	protein histidine kinase activity
APS56_RS14715	COG0784	Response regulator, receiver
APS56_RS14720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APS56_RS14725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APS56_RS14760	COG1595	DNA-templated transcription, initiation
APS56_RS14765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APS56_RS14770	COG0436	Aminotransferase
APS56_RS14780	COG0525	valine-tRNA ligase activity
APS56_RS14820	COG0018	arginyl-trna synthetase
APS56_RS14830	COG0659	secondary active sulfate transmembrane transporter activity
APS56_RS14835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APS56_RS14840	COG1181	Belongs to the D-alanine--D-alanine ligase family
APS56_RS14850	COG0564	pseudouridine synthase activity
APS56_RS14860	COG0702	epimerase
APS56_RS14865	COG3022	response to hydroperoxide
APS56_RS14890	COG0513	Belongs to the DEAD box helicase family
APS56_RS14900	COG4628	conserved protein (DUF2132)
APS56_RS14915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS56_RS14915	COG3153	acetyltransferase
APS56_RS14920	COG3152	Membrane
APS56_RS14925	COG1252	NADH dehydrogenase
APS56_RS14930	COG0159	tryptophan synthase activity
APS56_RS14935	COG0133	tryptophan synthase activity
APS56_RS14940	COG0135	phosphoribosylanthranilate isomerase activity
APS56_RS14945	COG0134	indole-3-glycerol-phosphate synthase activity
APS56_RS14950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APS56_RS14955	COG0512	Glutamine amidotransferase of anthranilate synthase
APS56_RS14960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APS56_RS14970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS56_RS14985	COG1312	Catalyzes the dehydration of D-mannonate
APS56_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
APS56_RS15005	COG0492	ferredoxin-NADP+ reductase activity
APS56_RS15040	COG3119	arylsulfatase activity
APS56_RS15045	COG1012	belongs to the aldehyde dehydrogenase family
APS56_RS15050	COG4977	sequence-specific DNA binding
APS56_RS15055	COG0235	Class ii aldolase
APS56_RS15060	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APS56_RS15105	COG1914	H( )-stimulated, divalent metal cation uptake system
APS56_RS15115	COG4948	Mandelate Racemase Muconate Lactonizing
APS56_RS15120	COG4771	TonB-dependent receptor
APS56_RS15125	COG0702	epimerase
APS56_RS15150	COG4771	TonB-dependent receptor
APS56_RS15155	COG0702	epimerase
APS56_RS15165	COG2186	Transcriptional regulator
APS56_RS15170	COG2271	Major facilitator Superfamily
APS56_RS15195	COG1132	(ABC) transporter
APS56_RS15200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APS56_RS15215	COG0254	rRNA binding
APS56_RS15230	COG4166	transmembrane transport
APS56_RS15235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS56_RS15265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APS56_RS15270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APS56_RS15275	COG1607	acyl-coa hydrolase
APS56_RS15295	COG1322	Protein conserved in bacteria
APS56_RS15300	COG1120	ATPase activity
APS56_RS15305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS56_RS15375	COG0484	heat shock protein binding
APS56_RS15380	COG0488	(ABC) transporter
APS56_RS15395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APS56_RS15400	COG1012	belongs to the aldehyde dehydrogenase family
APS56_RS15405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APS56_RS15430	COG0501	Belongs to the peptidase M48B family
APS56_RS15435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS56_RS15455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS56_RS15465	COG2195	Cleaves the N-terminal amino acid of tripeptides
APS56_RS15480	COG0215	cysteine-tRNA ligase activity
APS56_RS15485	COG0302	gtp cyclohydrolase
APS56_RS15500	COG0442	prolyl-tRNA aminoacylation
APS56_RS15510	COG0268	Binds directly to 16S ribosomal RNA
APS56_RS15525	COG2205	protein histidine kinase activity
APS56_RS15525	COG0745	RESPONSE REGULATOR receiver
APS56_RS15525	COG3292	Two component regulator propeller
APS56_RS15530	COG3119	arylsulfatase activity
APS56_RS15540	COG3250	beta-galactosidase activity
APS56_RS15545	COG3250	beta-galactosidase activity
APS56_RS15550	COG1629	transport
APS56_RS15560	COG4206	TonB-dependent receptor
APS56_RS15560	COG1629	transport
APS56_RS15565	COG0702	epimerase
APS56_RS15575	COG3119	arylsulfatase activity
APS56_RS15575	COG3408	Glycogen debranching enzyme
APS56_RS15595	COG4771	TonB-dependent receptor
APS56_RS15600	COG0702	epimerase
APS56_RS15610	COG0784	Response regulator, receiver
APS56_RS15620	COG4251	negative regulation of phosphorylation
APS56_RS15630	COG4251	negative regulation of phosphorylation
APS56_RS15640	COG3279	Response regulator of the LytR AlgR family
APS56_RS15705	COG0745	RESPONSE REGULATOR receiver
APS56_RS15720	COG4771	TonB-dependent receptor
APS56_RS15750	COG1131	(ABC) transporter
APS56_RS15760	COG0612	Peptidase, M16
APS56_RS15775	COG1629	transport
APS56_RS15780	COG0702	epimerase
APS56_RS15820	COG1678	Uncharacterized ACR, COG1678
APS56_RS15825	COG0776	regulation of translation
APS56_RS15830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APS56_RS15835	COG0514	ATP-dependent DNA helicase (RecQ)
APS56_RS15855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APS56_RS15860	COG0415	Belongs to the DNA photolyase family
APS56_RS15890	COG0673	inositol 2-dehydrogenase activity
APS56_RS15910	COG0656	L-ascorbic acid biosynthetic process
APS56_RS15915	COG0402	S-adenosylhomocysteine deaminase activity
APS56_RS15925	COG3279	Response regulator of the LytR AlgR family
APS56_RS16065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APS56_RS16080	COG0598	Magnesium transport protein CorA
APS56_RS16095	COG0424	maF-like protein
APS56_RS16120	COG1333	cytochrome c biogenesis protein
APS56_RS16120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS56_RS16125	COG1970	mechanosensitive ion channel activity
APS56_RS16140	COG0450	alkyl hydroperoxide reductase
APS56_RS16155	COG1393	Belongs to the ArsC family
APS56_RS16165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APS56_RS16175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APS56_RS16190	COG0156	8-amino-7-oxononanoate synthase activity
APS56_RS16225	COG0443	Heat shock 70 kDa protein
APS56_RS16240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APS56_RS16250	COG2070	2-Nitropropane dioxygenase
APS56_RS16265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS56_RS16270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APS56_RS16280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APS56_RS16295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS56_RS16300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APS56_RS16305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS56_RS16310	COG0824	Thioesterase
APS56_RS16315	COG1739	Uncharacterized protein family UPF0029
APS56_RS16325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS56_RS16325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APS56_RS16335	COG2890	protein-(glutamine-N5) methyltransferase activity
APS56_RS16340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APS56_RS16355	COG0737	Belongs to the 5'-nucleotidase family
APS56_RS16370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS56_RS16395	COG0497	DNA recombination
APS56_RS16400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APS56_RS16415	COG0237	dephospho-CoA kinase activity
APS56_RS16435	COG1733	regulation of RNA biosynthetic process
APS56_RS16485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS56_RS16495	COG1215	transferase activity, transferring glycosyl groups
APS56_RS16515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APS56_RS16520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APS56_RS16530	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS56_RS16535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APS56_RS16540	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS56_RS16550	COG1058	Belongs to the CinA family
APS56_RS16550	COG1546	Belongs to the CinA family
APS56_RS16555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APS56_RS16560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APS56_RS16565	COG0552	protein localization to endoplasmic reticulum
APS56_RS16575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS56_RS16600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS56_RS16605	COG0714	Associated with various cellular activities
APS56_RS16610	COG1049	propionate catabolic process, 2-methylcitrate cycle
APS56_RS16625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APS56_RS16630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APS56_RS16635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APS56_RS16640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)