locus-tag	class	description
GYM62_RS00030	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GYM62_RS00045	COG0006	proline dipeptidase activity
GYM62_RS00065	COG1011	Hydrolase
GYM62_RS00070	COG1012	belongs to the aldehyde dehydrogenase family
GYM62_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GYM62_RS00120	COG0584	glycerophosphoryl diester phosphodiesterase
GYM62_RS00130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GYM62_RS00135	COG0612	Peptidase, M16
GYM62_RS00140	COG0612	Peptidase, M16
GYM62_RS00150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GYM62_RS00155	COG0594	ribonuclease P activity
GYM62_RS00165	COG1214	PFAM Peptidase M22, glycoprotease
GYM62_RS00215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GYM62_RS00245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GYM62_RS00270	COG0563	adenylate kinase activity
GYM62_RS00275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GYM62_RS00280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GYM62_RS00285	COG0484	heat shock protein binding
GYM62_RS00295	COG4152	abc transporter atp-binding protein
GYM62_RS00300	COG1668	transmembrane transport
GYM62_RS00305	COG0783	Belongs to the Dps family
GYM62_RS00310	COG3852	Histidine kinase
GYM62_RS00315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GYM62_RS00370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GYM62_RS00375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GYM62_RS00380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GYM62_RS00385	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GYM62_RS00390	COG1805	sodium ion transport
GYM62_RS00395	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GYM62_RS00400	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GYM62_RS00405	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GYM62_RS00455	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS00465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GYM62_RS00470	COG3118	belongs to the thioredoxin family
GYM62_RS00480	COG0357	Ribosomal RNA small subunit methyltransferase G
GYM62_RS00485	COG1595	DNA-templated transcription, initiation
GYM62_RS00490	COG1215	transferase activity, transferring glycosyl groups
GYM62_RS00495	COG0343	queuine tRNA-ribosyltransferase activity
GYM62_RS00520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GYM62_RS00525	COG0129	dihydroxy-acid dehydratase activity
GYM62_RS00530	COG0028	Belongs to the TPP enzyme family
GYM62_RS00540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GYM62_RS00545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYM62_RS00550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GYM62_RS00555	COG0066	3-isopropylmalate dehydratase activity
GYM62_RS00600	COG2205	protein histidine kinase activity
GYM62_RS00620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYM62_RS00635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYM62_RS00645	COG0584	glycerophosphoryl diester phosphodiesterase
GYM62_RS00655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYM62_RS00675	COG1131	(ABC) transporter
GYM62_RS00715	COG0658	competence protein
GYM62_RS00715	COG2333	competence protein COMEC
GYM62_RS00725	COG0514	ATP-dependent DNA helicase (RecQ)
GYM62_RS00750	COG0009	L-threonylcarbamoyladenylate synthase
GYM62_RS00755	COG0126	phosphoglycerate kinase activity
GYM62_RS00765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GYM62_RS00770	COG0052	Belongs to the universal ribosomal protein uS2 family
GYM62_RS00775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GYM62_RS00785	COG0564	pseudouridine synthase activity
GYM62_RS00795	COG5002	protein histidine kinase activity
GYM62_RS00800	COG0745	RESPONSE REGULATOR receiver
GYM62_RS00810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GYM62_RS00815	COG1136	(ABC) transporter
GYM62_RS00815	COG0577	efflux transmembrane transporter activity
GYM62_RS00820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GYM62_RS00830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GYM62_RS00840	COG3275	phosphorelay sensor kinase activity
GYM62_RS00845	COG3279	Response regulator of the LytR AlgR family
GYM62_RS00860	COG0488	(ABC) transporter
GYM62_RS00880	COG1408	metallophosphoesterase
GYM62_RS00890	COG0436	Aminotransferase
GYM62_RS00905	COG0268	Binds directly to 16S ribosomal RNA
GYM62_RS00910	COG2003	Belongs to the UPF0758 family
GYM62_RS00945	COG1418	mRNA catabolic process
GYM62_RS00955	COG0246	Mannitol dehydrogenase
GYM62_RS00960	COG2721	sulfolactate sulfo-lyase activity
GYM62_RS00970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GYM62_RS00995	COG2205	protein histidine kinase activity
GYM62_RS01000	COG1556	Lactate utilization protein
GYM62_RS01005	COG1139	Iron-sulfur cluster binding protein
GYM62_RS01010	COG0247	lactate metabolic process
GYM62_RS01025	COG3119	arylsulfatase activity
GYM62_RS01030	COG4251	negative regulation of phosphorylation
GYM62_RS01060	COG2353	YceI-like domain
GYM62_RS01065	COG4654	Cytochrome c, class I
GYM62_RS01085	COG1064	alcohol dehydrogenase
GYM62_RS01130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GYM62_RS01135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GYM62_RS01135	COG0512	Glutamine amidotransferase of anthranilate synthase
GYM62_RS01140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GYM62_RS01145	COG0134	indole-3-glycerol-phosphate synthase activity
GYM62_RS01150	COG0135	phosphoribosylanthranilate isomerase activity
GYM62_RS01155	COG0133	tryptophan synthase activity
GYM62_RS01160	COG0159	tryptophan synthase activity
GYM62_RS01165	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GYM62_RS01170	COG3186	Phenylalanine-4-hydroxylase
GYM62_RS01180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GYM62_RS01185	COG0107	imidazoleglycerol-phosphate synthase activity
GYM62_RS01190	COG0140	phosphoribosyl-ATP diphosphatase activity
GYM62_RS01190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GYM62_RS01195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GYM62_RS01200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GYM62_RS01205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GYM62_RS01210	COG0673	inositol 2-dehydrogenase activity
GYM62_RS01230	COG4251	negative regulation of phosphorylation
GYM62_RS01250	COG3177	Filamentation induced by cAMP protein fic
GYM62_RS01270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GYM62_RS01280	COG0071	Belongs to the small heat shock protein (HSP20) family
GYM62_RS01285	COG0071	Belongs to the small heat shock protein (HSP20) family
GYM62_RS01290	COG3344	reverse transcriptase
GYM62_RS01310	COG3344	reverse transcriptase
GYM62_RS01325	COG3344	reverse transcriptase
GYM62_RS01340	COG4974	Belongs to the 'phage' integrase family
GYM62_RS01345	COG2826	transposase and inactivated derivatives, IS30 family
GYM62_RS01365	COG1940	carbohydrate kinase activity
GYM62_RS01370	COG0363	glucosamine-6-phosphate deaminase activity
GYM62_RS01380	COG3265	gluconokinase activity
GYM62_RS01385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GYM62_RS01415	COG1472	Belongs to the glycosyl hydrolase 3 family
GYM62_RS01420	COG2211	Major facilitator Superfamily
GYM62_RS01430	COG1649	PFAM Uncharacterised BCR, COG1649
GYM62_RS01440	COG1349	DNA-binding transcription factor activity
GYM62_RS01445	COG2366	antibiotic biosynthetic process
GYM62_RS01455	COG2010	Cytochrome c
GYM62_RS01485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GYM62_RS01510	COG3842	ATPase activity
GYM62_RS01520	COG2226	methyltransferase
GYM62_RS01530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GYM62_RS01535	COG0590	tRNA wobble adenosine to inosine editing
GYM62_RS01540	COG3279	Response regulator of the LytR AlgR family
GYM62_RS01545	COG3275	phosphorelay sensor kinase activity
GYM62_RS01555	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYM62_RS01555	COG0022	dehydrogenase e1 component
GYM62_RS01560	COG1012	belongs to the aldehyde dehydrogenase family
GYM62_RS01565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GYM62_RS01580	COG0124	histidyl-tRNA synthetase
GYM62_RS01610	COG4771	TonB-dependent receptor
GYM62_RS01630	COG1446	asparaginase
GYM62_RS01635	COG3142	Participates in the control of copper homeostasis
GYM62_RS01655	COG0193	aminoacyl-tRNA hydrolase activity
GYM62_RS01660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GYM62_RS01665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GYM62_RS01700	COG0359	binds to the 23S rRNA
GYM62_RS01705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GYM62_RS01710	COG0360	Binds together with S18 to 16S ribosomal RNA
GYM62_RS01730	COG2967	ApaG domain
GYM62_RS01735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GYM62_RS01745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GYM62_RS01755	COG1475	DNA binding
GYM62_RS01760	COG1192	Involved in chromosome partitioning
GYM62_RS01765	COG0706	membrane insertase activity
GYM62_RS01770	COG0504	CTP synthase activity
GYM62_RS01790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GYM62_RS01790	COG0617	tRNA 3'-terminal CCA addition
GYM62_RS01790	COG0517	IMP dehydrogenase activity
GYM62_RS01810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GYM62_RS01815	COG2884	Cell division ATP-binding protein ftsE
GYM62_RS01825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GYM62_RS01850	COG4771	TonB-dependent receptor
GYM62_RS01865	COG4771	TonB-dependent receptor
GYM62_RS01915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GYM62_RS01920	COG0732	type I restriction modification DNA specificity domain
GYM62_RS01925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GYM62_RS01935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GYM62_RS01980	COG1629	transport
GYM62_RS01980	COG4206	TonB-dependent receptor
GYM62_RS02030	COG3023	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS02080	COG5444	nuclease activity
GYM62_RS02120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GYM62_RS02135	COG3119	arylsulfatase activity
GYM62_RS02140	COG0745	RESPONSE REGULATOR receiver
GYM62_RS02140	COG3292	Two component regulator propeller
GYM62_RS02140	COG2205	protein histidine kinase activity
GYM62_RS02145	COG1629	transport
GYM62_RS02150	COG4771	TonB-dependent receptor
GYM62_RS02155	COG0702	epimerase
GYM62_RS02160	COG3119	arylsulfatase activity
GYM62_RS02170	COG3119	arylsulfatase activity
GYM62_RS02175	COG1295	ribonuclease BN
GYM62_RS02185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GYM62_RS02190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GYM62_RS02195	COG0494	nUDIX hydrolase
GYM62_RS02200	COG0009	L-threonylcarbamoyladenylate synthase
GYM62_RS02210	COG0542	response to heat
GYM62_RS02225	COG1796	DNA polymerase
GYM62_RS02225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GYM62_RS02240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GYM62_RS02245	COG0540	Belongs to the ATCase OTCase family
GYM62_RS02255	COG1131	(ABC) transporter
GYM62_RS02280	COG0539	negative regulation of cytoplasmic translation
GYM62_RS02280	COG2183	response to ionizing radiation
GYM62_RS02295	COG0437	4 iron, 4 sulfur cluster binding
GYM62_RS02325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GYM62_RS02330	COG1612	heme a metabolic process
GYM62_RS02335	COG0109	protoheme IX farnesyltransferase activity
GYM62_RS02345	COG1845	cytochrome c oxidase, subunit III
GYM62_RS02360	COG2322	membrane
GYM62_RS02370	COG5000	phosphorelay sensor kinase activity
GYM62_RS02380	COG0300	oxidoreductase activity
GYM62_RS02385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GYM62_RS02400	COG0488	(ABC) transporter
GYM62_RS02405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GYM62_RS02410	COG2205	protein histidine kinase activity
GYM62_RS02415	COG2205	protein histidine kinase activity
GYM62_RS02415	COG0784	Response regulator, receiver
GYM62_RS02420	COG1136	(ABC) transporter
GYM62_RS02435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GYM62_RS02450	COG1999	signal sequence binding
GYM62_RS02455	COG1981	membrane
GYM62_RS02465	COG1703	isobutyryl-CoA mutase activity
GYM62_RS02485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYM62_RS02490	COG1120	ATPase activity
GYM62_RS02500	COG0492	ferredoxin-NADP+ reductase activity
GYM62_RS02505	COG0633	Ferredoxin
GYM62_RS02520	COG2851	Citrate transporter
GYM62_RS02540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYM62_RS02540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYM62_RS02545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYM62_RS02550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GYM62_RS02560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GYM62_RS02565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GYM62_RS02570	COG0750	zinc metalloprotease
GYM62_RS02590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GYM62_RS02595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GYM62_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS02610	COG1278	Cold shock
GYM62_RS02615	COG0071	Belongs to the small heat shock protein (HSP20) family
GYM62_RS02625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GYM62_RS02630	COG0740	serine-type endopeptidase activity
GYM62_RS02635	COG0544	peptidyl-prolyl cis-trans isomerase activity
GYM62_RS02645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GYM62_RS02650	COG0735	belongs to the Fur family
GYM62_RS02655	COG1366	Belongs to the anti-sigma-factor antagonist family
GYM62_RS02660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GYM62_RS02695	COG2217	Heavy metal translocating P-type atpase
GYM62_RS02715	COG2010	Cytochrome c
GYM62_RS02720	COG0348	domain, Protein
GYM62_RS02735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GYM62_RS02745	COG2304	oxidoreductase activity
GYM62_RS02775	COG1131	(ABC) transporter
GYM62_RS02780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GYM62_RS02785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GYM62_RS02785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GYM62_RS02790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GYM62_RS02795	COG1078	dGTPase activity
GYM62_RS02805	COG0802	atpase or kinase
GYM62_RS02810	COG0686	Belongs to the AlaDH PNT family
GYM62_RS02850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GYM62_RS02865	COG0481	GTPase activity
GYM62_RS02875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GYM62_RS02890	COG2205	protein histidine kinase activity
GYM62_RS02890	COG0784	Response regulator, receiver
GYM62_RS02895	COG2204	response regulator
GYM62_RS02925	COG0525	valine-tRNA ligase activity
GYM62_RS02935	COG4771	TonB-dependent receptor
GYM62_RS02950	COG1115	amino acid carrier protein
GYM62_RS02990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYM62_RS03040	COG0629	single-stranded DNA binding
GYM62_RS03060	COG0657	acetylesterase activity
GYM62_RS03060	COG2755	lipolytic protein G-D-S-L family
GYM62_RS03070	COG0352	thiamine-phosphate diphosphorylase activity
GYM62_RS03080	COG2226	methyltransferase
GYM62_RS03090	COG0738	Major facilitator superfamily
GYM62_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS03105	COG0179	Fumarylacetoacetate (FAA) hydrolase
GYM62_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS03125	COG0784	Response regulator, receiver
GYM62_RS03130	COG4251	negative regulation of phosphorylation
GYM62_RS03135	COG4251	negative regulation of phosphorylation
GYM62_RS03140	COG0673	inositol 2-dehydrogenase activity
GYM62_RS03145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GYM62_RS03160	COG2382	esterase
GYM62_RS03170	COG0628	permease
GYM62_RS03175	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GYM62_RS03175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GYM62_RS03190	COG1401	restriction endodeoxyribonuclease activity
GYM62_RS03230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GYM62_RS03235	COG2706	6-phosphogluconolactonase activity
GYM62_RS03245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GYM62_RS03250	COG3279	Response regulator of the LytR AlgR family
GYM62_RS03275	COG4974	Belongs to the 'phage' integrase family
GYM62_RS03355	COG0860	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS03410	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GYM62_RS03430	COG0375	protein maturation
GYM62_RS03435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GYM62_RS03440	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GYM62_RS03445	COG0298	carbon dioxide binding
GYM62_RS03500	COG2003	Belongs to the UPF0758 family
GYM62_RS03505	COG0629	single-stranded DNA binding
GYM62_RS03515	COG0513	Belongs to the DEAD box helicase family
GYM62_RS03535	COG0477	Major facilitator Superfamily
GYM62_RS03545	COG0671	phosphoesterase, PA-phosphatase related
GYM62_RS03550	COG0408	coproporphyrinogen oxidase activity
GYM62_RS03560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GYM62_RS03585	COG2151	metal-sulfur cluster biosynthetic enzyme
GYM62_RS03590	COG2166	iron-sulfur cluster assembly
GYM62_RS03595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GYM62_RS03600	COG0719	Fe-S assembly protein
GYM62_RS03605	COG0396	ATPase activity
GYM62_RS03610	COG0719	Fe-S assembly protein
GYM62_RS03615	COG1522	sequence-specific DNA binding
GYM62_RS03630	COG1506	peptidase
GYM62_RS03630	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS03635	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GYM62_RS03700	COG1216	Glycosyl transferase, family 2
GYM62_RS03700	COG0463	Glycosyl transferase, family 2
GYM62_RS03720	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS03725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GYM62_RS03740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GYM62_RS03750	COG0489	protein tyrosine kinase activity
GYM62_RS03770	COG0463	Glycosyl transferase, family 2
GYM62_RS03770	COG1216	Glycosyl transferase, family 2
GYM62_RS03775	COG0367	asparagine synthase
GYM62_RS03780	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS03780	COG0297	glycogen (starch) synthase activity
GYM62_RS03790	COG0367	asparagine synthase
GYM62_RS03805	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS03810	COG0367	asparagine synthase
GYM62_RS03825	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS03845	COG1063	alcohol dehydrogenase
GYM62_RS03860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GYM62_RS03865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GYM62_RS03895	COG3291	Pkd domain containing protein
GYM62_RS03935	COG3344	reverse transcriptase
GYM62_RS03970	COG0463	Glycosyl transferase, family 2
GYM62_RS03990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GYM62_RS04015	COG0110	maltose O-acetyltransferase activity
GYM62_RS04025	COG3754	Rhamnan synthesis protein F
GYM62_RS04030	COG0463	Glycosyl transferase, family 2
GYM62_RS04030	COG1216	Glycosyl transferase, family 2
GYM62_RS04045	COG0463	Glycosyl transferase, family 2
GYM62_RS04045	COG1216	Glycosyl transferase, family 2
GYM62_RS04055	COG1216	Glycosyl transferase, family 2
GYM62_RS04055	COG0463	Glycosyl transferase, family 2
GYM62_RS04070	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS04080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GYM62_RS04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS04090	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS04110	COG1629	transport
GYM62_RS04110	COG4206	TonB-dependent receptor
GYM62_RS04150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GYM62_RS04170	COG0860	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS04175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYM62_RS04200	COG3599	regulation of cell shape
GYM62_RS04205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GYM62_RS04205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GYM62_RS04220	COG0316	Belongs to the HesB IscA family
GYM62_RS04240	COG0702	epimerase
GYM62_RS04245	COG1490	D-aminoacyl-tRNA deacylase activity
GYM62_RS04250	COG1119	ATPase activity
GYM62_RS04265	COG1694	Mazg nucleotide pyrophosphohydrolase
GYM62_RS04285	COG2045	Belongs to the ComB family
GYM62_RS04290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GYM62_RS04295	COG0316	Belongs to the HesB IscA family
GYM62_RS04300	COG1082	Xylose isomerase domain protein TIM barrel
GYM62_RS04300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GYM62_RS04305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GYM62_RS04315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GYM62_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS04330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GYM62_RS04330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GYM62_RS04350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GYM62_RS04355	COG0247	lactate metabolic process
GYM62_RS04355	COG0277	FAD linked oxidase domain protein
GYM62_RS04370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GYM62_RS04375	COG1228	amidohydrolase
GYM62_RS04380	COG2986	histidine ammonia-lyase
GYM62_RS04385	COG0583	DNA-binding transcription factor activity
GYM62_RS04400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GYM62_RS04410	COG2050	protein possibly involved in aromatic compounds catabolism
GYM62_RS04415	COG0406	alpha-ribazole phosphatase activity
GYM62_RS04430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GYM62_RS04435	COG1663	tetraacyldisaccharide 4'-kinase activity
GYM62_RS04450	COG0577	efflux transmembrane transporter activity
GYM62_RS04470	COG3655	Transcriptional regulator
GYM62_RS04500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GYM62_RS04510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYM62_RS04520	COG1629	transport
GYM62_RS04535	COG1940	carbohydrate kinase activity
GYM62_RS04540	COG0445	tRNA wobble uridine modification
GYM62_RS04555	COG1595	DNA-templated transcription, initiation
GYM62_RS04595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS04620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GYM62_RS04625	COG0303	'Molybdopterin
GYM62_RS04630	COG0730	response to heat
GYM62_RS04640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GYM62_RS04645	COG0314	molybdopterin synthase activity
GYM62_RS04655	COG0521	Mo-molybdopterin cofactor biosynthetic process
GYM62_RS04655	COG0315	cyclic pyranopterin monophosphate synthase activity
GYM62_RS04695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GYM62_RS04700	COG2183	response to ionizing radiation
GYM62_RS04715	COG2826	transposase and inactivated derivatives, IS30 family
GYM62_RS04725	COG1943	Transposase
GYM62_RS04735	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GYM62_RS04750	COG3620	sequence-specific DNA binding
GYM62_RS04800	COG3119	arylsulfatase activity
GYM62_RS04815	COG1940	carbohydrate kinase activity
GYM62_RS04835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GYM62_RS04840	COG2135	peptidase activity
GYM62_RS04845	COG0429	hydrolase of the alpha beta-hydrolase fold
GYM62_RS04855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GYM62_RS04875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYM62_RS04890	COG0667	Aldo Keto reductase
GYM62_RS04895	COG1288	antiporter activity
GYM62_RS04905	COG2072	flavoprotein involved in K transport
GYM62_RS04915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GYM62_RS04925	COG2062	phosphohistidine phosphatase, SixA
GYM62_RS04950	COG5520	Belongs to the glycosyl hydrolase 30 family
GYM62_RS04965	COG4946	Tricorn protease homolog
GYM62_RS04965	COG0793	Belongs to the peptidase S41A family
GYM62_RS05090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYM62_RS05100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GYM62_RS05110	COG0179	Fumarylacetoacetate (FAA) hydrolase
GYM62_RS05120	COG1619	proteins homologs of microcin C7 resistance protein MccF
GYM62_RS05130	COG2363	Small membrane protein
GYM62_RS05150	COG0686	Belongs to the AlaDH PNT family
GYM62_RS05155	COG0022	dehydrogenase e1 component
GYM62_RS05170	COG2204	response regulator
GYM62_RS05180	COG4772	TonB-dependent receptor
GYM62_RS05205	COG2326	polyphosphate kinase activity
GYM62_RS05210	COG1404	Belongs to the peptidase S8 family
GYM62_RS05215	COG1404	Belongs to the peptidase S8 family
GYM62_RS05225	COG0587	DNA-directed DNA polymerase activity
GYM62_RS05240	COG0745	RESPONSE REGULATOR receiver
GYM62_RS05240	COG2205	protein histidine kinase activity
GYM62_RS05240	COG4191	Histidine kinase
GYM62_RS05265	COG2514	catechol 2,3-dioxygenase activity
GYM62_RS05270	COG3661	Belongs to the glycosyl hydrolase 67 family
GYM62_RS05275	COG1074	ATP-dependent DNA helicase activity
GYM62_RS05295	COG0251	oxidation-reduction process
GYM62_RS05300	COG0456	acetyltransferase
GYM62_RS05310	COG1283	sodium-dependent phosphate transmembrane transporter activity
GYM62_RS05320	COG1511	domain protein
GYM62_RS05320	COG3264	Mechanosensitive ion channel
GYM62_RS05325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYM62_RS05325	COG3153	acetyltransferase
GYM62_RS05330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GYM62_RS05335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GYM62_RS05340	COG2989	Protein conserved in bacteria
GYM62_RS05355	COG0302	gtp cyclohydrolase
GYM62_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS05390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GYM62_RS05390	COG0519	Catalyzes the synthesis of GMP from XMP
GYM62_RS05400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GYM62_RS05410	COG1393	Belongs to the ArsC family
GYM62_RS05415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS05420	COG0156	8-amino-7-oxononanoate synthase activity
GYM62_RS05425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GYM62_RS05430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GYM62_RS05445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GYM62_RS05460	COG0442	prolyl-tRNA aminoacylation
GYM62_RS05470	COG4864	UPF0365 protein
GYM62_RS05480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GYM62_RS05520	COG1215	transferase activity, transferring glycosyl groups
GYM62_RS05565	COG0673	inositol 2-dehydrogenase activity
GYM62_RS05595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYM62_RS05630	COG4807	Protein conserved in bacteria
GYM62_RS05655	COG2217	Heavy metal translocating P-type atpase
GYM62_RS05660	COG2207	Transcriptional regulator
GYM62_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
GYM62_RS05690	COG1760	l-serine dehydratase
GYM62_RS05695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GYM62_RS05705	COG1070	Carbohydrate kinase
GYM62_RS05710	COG2115	Belongs to the xylose isomerase family
GYM62_RS05740	COG2329	Antibiotic biosynthesis monooxygenase
GYM62_RS05775	COG0656	L-ascorbic acid biosynthetic process
GYM62_RS05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GYM62_RS05810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GYM62_RS05840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GYM62_RS05845	COG0589	response to stress
GYM62_RS05875	COG0811	peptide transport
GYM62_RS05880	COG0848	biopolymer transport protein
GYM62_RS05895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GYM62_RS05900	COG0784	Response regulator, receiver
GYM62_RS05900	COG2205	protein histidine kinase activity
GYM62_RS05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYM62_RS05905	COG1024	Enoyl-CoA hydratase
GYM62_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS05925	COG1063	alcohol dehydrogenase
GYM62_RS05995	COG0732	type I restriction modification DNA specificity domain
GYM62_RS06005	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS06045	COG0405	Gamma-glutamyltransferase
GYM62_RS06050	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS06050	COG1506	peptidase
GYM62_RS06075	COG1428	Deoxynucleoside kinase
GYM62_RS06080	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYM62_RS06085	COG2996	Protein conserved in bacteria
GYM62_RS06135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GYM62_RS06140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GYM62_RS06150	COG1309	transcriptional regulator
GYM62_RS06155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GYM62_RS06160	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS06175	COG1950	PFAM Membrane protein of
GYM62_RS06190	COG0123	including yeast histone deacetylase and acetoin utilization protein
GYM62_RS06205	COG2885	chlorophyll binding
GYM62_RS06205	COG3047	cAMP biosynthetic process
GYM62_RS06220	COG1115	amino acid carrier protein
GYM62_RS06225	COG1929	Belongs to the glycerate kinase type-1 family
GYM62_RS06245	COG3279	Response regulator of the LytR AlgR family
GYM62_RS06265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GYM62_RS06275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYM62_RS06285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GYM62_RS06295	COG3250	beta-galactosidase activity
GYM62_RS06300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GYM62_RS06325	COG1301	dicarboxylic acid transport
GYM62_RS06330	COG3360	Dodecin
GYM62_RS06355	COG0531	amino acid
GYM62_RS06370	COG0436	Aminotransferase
GYM62_RS06410	COG3239	Fatty acid desaturase
GYM62_RS06415	COG0006	proline dipeptidase activity
GYM62_RS06540	COG4206	TonB-dependent receptor
GYM62_RS06540	COG1629	transport
GYM62_RS06575	COG1196	nuclear chromosome segregation
GYM62_RS06590	COG0723	plastoquinol--plastocyanin reductase activity
GYM62_RS06620	COG0791	NLP P60 protein
GYM62_RS06625	COG1228	amidohydrolase
GYM62_RS06630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYM62_RS06640	COG0745	RESPONSE REGULATOR receiver
GYM62_RS06680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYM62_RS06695	COG1473	amidohydrolase
GYM62_RS06710	COG0513	Belongs to the DEAD box helicase family
GYM62_RS06720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GYM62_RS06750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GYM62_RS06775	COG1132	(ABC) transporter
GYM62_RS06875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GYM62_RS06880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GYM62_RS06885	COG0196	riboflavin kinase activity
GYM62_RS06890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GYM62_RS06900	COG2177	Part of the ABC transporter FtsEX involved in
GYM62_RS06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYM62_RS06920	COG2873	o-acetylhomoserine
GYM62_RS06925	COG0288	reversible hydration of carbon dioxide
GYM62_RS06935	COG0165	Argininosuccinate lyase
GYM62_RS06940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GYM62_RS06945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GYM62_RS06960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GYM62_RS06965	COG0137	argininosuccinate synthase activity
GYM62_RS06975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GYM62_RS06985	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GYM62_RS07030	COG1643	Atp-dependent helicase
GYM62_RS07040	COG0673	inositol 2-dehydrogenase activity
GYM62_RS07075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GYM62_RS07085	COG1733	regulation of RNA biosynthetic process
GYM62_RS07090	COG1104	cysteine desulfurase activity
GYM62_RS07095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GYM62_RS07100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GYM62_RS07130	COG0471	metal ion transport
GYM62_RS07135	COG3275	phosphorelay sensor kinase activity
GYM62_RS07140	COG3279	Response regulator of the LytR AlgR family
GYM62_RS07150	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GYM62_RS07155	COG1082	Xylose isomerase domain protein TIM barrel
GYM62_RS07160	COG0673	inositol 2-dehydrogenase activity
GYM62_RS07190	COG1678	Uncharacterized ACR, COG1678
GYM62_RS07195	COG0259	pyridoxamine-phosphate oxidase activity
GYM62_RS07205	COG0739	heme binding
GYM62_RS07210	COG0492	ferredoxin-NADP+ reductase activity
GYM62_RS07215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GYM62_RS07220	COG1185	polyribonucleotide nucleotidyltransferase activity
GYM62_RS07225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GYM62_RS07255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GYM62_RS07260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GYM62_RS07265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GYM62_RS07270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GYM62_RS07285	COG0579	oxidoreductase
GYM62_RS07290	COG0069	glutamate synthase activity
GYM62_RS07305	COG2081	HI0933 family
GYM62_RS07310	COG0433	COG0433 Predicted ATPase
GYM62_RS07330	COG2171	N-acyltransferase activity
GYM62_RS07345	COG0803	Belongs to the bacterial solute-binding protein 9 family
GYM62_RS07350	COG1121	(ABC) transporter
GYM62_RS07355	COG1321	iron dependent repressor
GYM62_RS07355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GYM62_RS07360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GYM62_RS07370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GYM62_RS07380	COG4916	TIR domain
GYM62_RS07430	COG1126	abc transporter atp-binding protein
GYM62_RS07435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GYM62_RS07445	COG1819	glycosyl
GYM62_RS07450	COG1621	beta-fructofuranosidase activity
GYM62_RS07465	COG0733	neurotransmitter:sodium symporter activity
GYM62_RS07475	COG2249	NAD(P)H dehydrogenase (quinone) activity
GYM62_RS07490	COG2340	Cysteine-rich secretory protein family
GYM62_RS07505	COG0482	sulfurtransferase activity
GYM62_RS07510	COG0564	pseudouridine synthase activity
GYM62_RS07520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GYM62_RS07530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GYM62_RS07535	COG2086	electron transfer activity
GYM62_RS07550	COG0604	alcohol dehydrogenase
GYM62_RS07555	COG0305	Participates in initiation and elongation during chromosome replication
GYM62_RS07565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GYM62_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GYM62_RS07610	COG0384	phenazine biosynthesis protein PhzF
GYM62_RS07625	COG1528	Iron-storage protein
GYM62_RS07645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYM62_RS07655	COG0307	riboflavin synthase, alpha
GYM62_RS07660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GYM62_RS07675	COG2814	Major facilitator Superfamily
GYM62_RS07685	COG0424	maF-like protein
GYM62_RS07695	COG0439	Biotin carboxylase
GYM62_RS07700	COG0156	8-amino-7-oxononanoate synthase activity
GYM62_RS07720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GYM62_RS07725	COG0531	amino acid
GYM62_RS07745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GYM62_RS07750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GYM62_RS07755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GYM62_RS07760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GYM62_RS07775	COG2201	protein-glutamate methylesterase activity
GYM62_RS07800	COG0010	Belongs to the arginase family
GYM62_RS07805	COG0018	arginyl-trna synthetase
GYM62_RS07810	COG0386	Belongs to the glutathione peroxidase family
GYM62_RS07815	COG1575	Belongs to the MenA family. Type 1 subfamily
GYM62_RS07820	COG0589	response to stress
GYM62_RS07835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GYM62_RS07840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GYM62_RS07845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYM62_RS07850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GYM62_RS07850	COG0131	Imidazoleglycerol-phosphate dehydratase
GYM62_RS07865	COG0463	Glycosyl transferase, family 2
GYM62_RS07870	COG0577	efflux transmembrane transporter activity
GYM62_RS07875	COG3876	Protein conserved in bacteria
GYM62_RS07880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GYM62_RS07890	COG0300	oxidoreductase activity
GYM62_RS07895	COG1058	Belongs to the CinA family
GYM62_RS07895	COG1546	Belongs to the CinA family
GYM62_RS07900	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYM62_RS07905	COG2205	protein histidine kinase activity
GYM62_RS07905	COG0784	Response regulator, receiver
GYM62_RS07925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYM62_RS07925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYM62_RS07925	COG1703	isobutyryl-CoA mutase activity
GYM62_RS07930	COG0427	acetyl-CoA hydrolase
GYM62_RS07935	COG2814	Major facilitator Superfamily
GYM62_RS07960	COG1793	dna ligase
GYM62_RS07965	COG1201	RNA secondary structure unwinding
GYM62_RS07970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GYM62_RS07990	COG1914	H( )-stimulated, divalent metal cation uptake system
GYM62_RS08010	COG1970	mechanosensitive ion channel activity
GYM62_RS08015	COG1770	oligopeptidase
GYM62_RS08020	COG1803	Methylglyoxal synthase
GYM62_RS08025	COG0205	6-phosphofructokinase activity
GYM62_RS08040	COG2814	Major facilitator Superfamily
GYM62_RS08055	COG0534	Mate efflux family protein
GYM62_RS08065	COG1522	sequence-specific DNA binding
GYM62_RS08085	COG0415	Belongs to the DNA photolyase family
GYM62_RS08110	COG0730	response to heat
GYM62_RS08115	COG0589	response to stress
GYM62_RS08120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYM62_RS08170	COG2321	neutral zinc metallopeptidase
GYM62_RS08200	COG4206	TonB-dependent receptor
GYM62_RS08205	COG2304	oxidoreductase activity
GYM62_RS08220	COG0183	Belongs to the thiolase family
GYM62_RS08230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GYM62_RS08240	COG1234	tRNA 3'-trailer cleavage
GYM62_RS08245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GYM62_RS08250	COG0513	Belongs to the DEAD box helicase family
GYM62_RS08265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GYM62_RS08265	COG0758	DNA mediated transformation
GYM62_RS08295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GYM62_RS08300	COG0646	methionine synthase
GYM62_RS08300	COG1410	methionine synthase
GYM62_RS08315	COG2205	protein histidine kinase activity
GYM62_RS08315	COG0784	Response regulator, receiver
GYM62_RS08320	COG0393	Putative heavy-metal-binding
GYM62_RS08345	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GYM62_RS08355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GYM62_RS08385	COG1030	water channel activity
GYM62_RS08400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GYM62_RS08410	COG1136	(ABC) transporter
GYM62_RS08420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GYM62_RS08425	COG2235	arginine
GYM62_RS08435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GYM62_RS08445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GYM62_RS08445	COG1605	Chorismate mutase
GYM62_RS08450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GYM62_RS08455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GYM62_RS08460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GYM62_RS08465	COG0077	Prephenate dehydratase
GYM62_RS08465	COG1605	Chorismate mutase
GYM62_RS08470	COG0436	Aminotransferase
GYM62_RS08540	COG4771	TonB-dependent receptor
GYM62_RS08545	COG1321	iron dependent repressor
GYM62_RS08550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GYM62_RS08555	COG3279	Response regulator of the LytR AlgR family
GYM62_RS08575	COG0436	Aminotransferase
GYM62_RS08585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GYM62_RS08595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GYM62_RS08600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GYM62_RS08605	COG1984	allophanate hydrolase subunit 2
GYM62_RS08615	COG0116	Belongs to the methyltransferase superfamily
GYM62_RS08615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GYM62_RS08630	COG4771	TonB-dependent receptor
GYM62_RS08640	COG1609	Transcriptional regulator
GYM62_RS08645	COG1904	glucuronate isomerase
GYM62_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS08655	COG1312	Catalyzes the dehydration of D-mannonate
GYM62_RS08660	COG0110	maltose O-acetyltransferase activity
GYM62_RS08665	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS08670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS08680	COG0318	PFAM AMP-dependent synthetase and ligase
GYM62_RS08685	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS08705	COG1335	isochorismatase
GYM62_RS08710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GYM62_RS08750	COG1136	(ABC) transporter
GYM62_RS08755	COG0045	succinate-CoA ligase (ADP-forming) activity
GYM62_RS08775	COG0471	metal ion transport
GYM62_RS08775	COG3273	potassium ion transport
GYM62_RS08785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GYM62_RS08790	COG0187	DNA topoisomerase II activity
GYM62_RS08830	COG0116	Belongs to the methyltransferase superfamily
GYM62_RS08830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GYM62_RS08835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYM62_RS08855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYM62_RS08865	COG0667	Aldo Keto reductase
GYM62_RS08870	COG0205	6-phosphofructokinase activity
GYM62_RS08880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GYM62_RS08885	COG4999	Histidine kinase
GYM62_RS08885	COG3850	Histidine kinase
GYM62_RS08885	COG3437	response regulator, receiver
GYM62_RS08885	COG2205	protein histidine kinase activity
GYM62_RS08900	COG0321	lipoyl(octanoyl) transferase activity
GYM62_RS08900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GYM62_RS08905	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GYM62_RS08915	COG3279	Response regulator of the LytR AlgR family
GYM62_RS08920	COG3275	phosphorelay sensor kinase activity
GYM62_RS08925	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYM62_RS08945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYM62_RS08950	COG0571	ribonuclease III activity
GYM62_RS08955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYM62_RS08955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GYM62_RS08960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GYM62_RS08965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GYM62_RS08995	COG0339	signal peptide processing
GYM62_RS09000	COG0628	permease
GYM62_RS09010	COG0784	Response regulator, receiver
GYM62_RS09010	COG2205	protein histidine kinase activity
GYM62_RS09030	COG2031	fatty acid transporter
GYM62_RS09040	COG2205	protein histidine kinase activity
GYM62_RS09050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GYM62_RS09055	COG4251	negative regulation of phosphorylation
GYM62_RS09060	COG2204	response regulator
GYM62_RS09070	COG0628	permease
GYM62_RS09075	COG0012	GTP binding
GYM62_RS09095	COG0488	(ABC) transporter
GYM62_RS09105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GYM62_RS09105	COG1199	ATP-dependent helicase activity
GYM62_RS09110	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GYM62_RS09120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GYM62_RS09125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GYM62_RS09130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GYM62_RS09140	COG4771	TonB-dependent receptor
GYM62_RS09155	COG3023	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS09215	COG1629	transport
GYM62_RS09215	COG4206	TonB-dependent receptor
GYM62_RS09260	COG2801	Transposase and inactivated derivatives
GYM62_RS09310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GYM62_RS09380	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GYM62_RS09390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS09405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GYM62_RS09405	COG0662	Cupin 2, conserved barrel domain protein
GYM62_RS09425	COG3206	protein involved in exopolysaccharide biosynthesis
GYM62_RS09425	COG0489	protein tyrosine kinase activity
GYM62_RS09435	COG0366	Alpha amylase catalytic
GYM62_RS09445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GYM62_RS09455	COG1609	Transcriptional regulator
GYM62_RS09485	COG0784	Response regulator, receiver
GYM62_RS09485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GYM62_RS09485	COG2198	Histidine kinase
GYM62_RS09485	COG2205	protein histidine kinase activity
GYM62_RS09490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GYM62_RS09500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GYM62_RS09500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GYM62_RS09505	COG0358	DNA primase activity
GYM62_RS09510	COG0489	protein tyrosine kinase activity
GYM62_RS09515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GYM62_RS09535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GYM62_RS09545	COG1011	Hydrolase
GYM62_RS09590	COG0697	spore germination
GYM62_RS09605	COG1573	uracil-dna glycosylase
GYM62_RS09630	COG1136	(ABC) transporter
GYM62_RS09635	COG4591	ABC-type transport system involved in lipoprotein release permease component
GYM62_RS09645	COG0577	efflux transmembrane transporter activity
GYM62_RS09650	COG3781	membrane
GYM62_RS09665	COG0577	efflux transmembrane transporter activity
GYM62_RS09670	COG1136	(ABC) transporter
GYM62_RS09670	COG0577	efflux transmembrane transporter activity
GYM62_RS09685	COG2204	response regulator
GYM62_RS09690	COG4191	Histidine kinase
GYM62_RS09700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GYM62_RS09720	COG0732	type I restriction modification DNA specificity domain
GYM62_RS09775	COG1752	Esterase of the alpha-beta hydrolase superfamily
GYM62_RS09780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYM62_RS09785	COG0825	malonyl-CoA metabolic process
GYM62_RS09800	COG0405	Gamma-glutamyltransferase
GYM62_RS09830	COG0488	(ABC) transporter
GYM62_RS09840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GYM62_RS09855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GYM62_RS09860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYM62_RS09865	COG2239	Acts as a magnesium transporter
GYM62_RS09870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GYM62_RS09875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GYM62_RS09885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GYM62_RS09890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GYM62_RS09895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GYM62_RS09900	COG0511	ligase activity, forming carbon-carbon bonds
GYM62_RS09905	COG0439	Biotin carboxylase
GYM62_RS09940	COG2826	transposase and inactivated derivatives, IS30 family
GYM62_RS09990	COG0629	single-stranded DNA binding
GYM62_RS10035	COG2308	Evidence 4 Homologs of previously reported genes of
GYM62_RS10040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GYM62_RS10045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GYM62_RS10045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GYM62_RS10055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GYM62_RS10060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYM62_RS10065	COG1570	exodeoxyribonuclease VII activity
GYM62_RS10085	COG1132	(ABC) transporter
GYM62_RS10090	COG0861	Integral membrane protein TerC family
GYM62_RS10100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYM62_RS10120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GYM62_RS10125	COG1051	belongs to the nudix hydrolase family
GYM62_RS10130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GYM62_RS10145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GYM62_RS10165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GYM62_RS10175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GYM62_RS10175	COG0512	Glutamine amidotransferase of anthranilate synthase
GYM62_RS10180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GYM62_RS10185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYM62_RS10220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GYM62_RS10225	COG0459	protein refolding
GYM62_RS10230	COG2201	protein-glutamate methylesterase activity
GYM62_RS10245	COG1228	amidohydrolase
GYM62_RS10260	COG2388	GCN5-related N-acetyl-transferase
GYM62_RS10280	COG4654	Cytochrome c, class I
GYM62_RS10325	COG5002	protein histidine kinase activity
GYM62_RS10330	COG0745	RESPONSE REGULATOR receiver
GYM62_RS10345	COG2267	carboxylic ester hydrolase activity
GYM62_RS10360	COG2826	transposase and inactivated derivatives, IS30 family
GYM62_RS10370	COG3023	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS10425	COG0702	epimerase
GYM62_RS10430	COG1629	transport
GYM62_RS10430	COG4206	TonB-dependent receptor
GYM62_RS10595	COG2217	Heavy metal translocating P-type atpase
GYM62_RS10610	COG1742	UPF0060 membrane protein
GYM62_RS10685	COG0347	Belongs to the P(II) protein family
GYM62_RS10725	COG2132	Multicopper oxidase
GYM62_RS10760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GYM62_RS10780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GYM62_RS10790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYM62_RS10810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GYM62_RS10815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GYM62_RS10820	COG0298	carbon dioxide binding
GYM62_RS10825	COG0409	Hydrogenase expression formation protein
GYM62_RS10830	COG0309	Hydrogenase expression formation protein (HypE)
GYM62_RS10850	COG0375	protein maturation
GYM62_RS10870	COG3344	reverse transcriptase
GYM62_RS10885	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GYM62_RS10905	COG1120	ATPase activity
GYM62_RS10910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYM62_RS10935	COG4115	mRNA cleavage
GYM62_RS10940	COG2161	toxin-antitoxin pair type II binding
GYM62_RS10955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GYM62_RS10970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYM62_RS11055	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GYM62_RS11060	COG4771	TonB-dependent receptor
GYM62_RS11075	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS11075	COG1506	peptidase
GYM62_RS11075	COG4946	Tricorn protease homolog
GYM62_RS11095	COG1595	DNA-templated transcription, initiation
GYM62_RS11115	COG1331	Highly conserved protein containing a thioredoxin domain
GYM62_RS11120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GYM62_RS11145	COG4591	ABC-type transport system involved in lipoprotein release permease component
GYM62_RS11150	COG1136	(ABC) transporter
GYM62_RS11155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS11175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GYM62_RS11185	COG2610	gluconate transmembrane transporter activity
GYM62_RS11200	COG2361	Protein of unknown function DUF86
GYM62_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS11240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GYM62_RS11245	COG0531	amino acid
GYM62_RS11265	COG3344	reverse transcriptase
GYM62_RS11270	COG4974	Belongs to the 'phage' integrase family
GYM62_RS11285	COG0517	IMP dehydrogenase activity
GYM62_RS11310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GYM62_RS11330	COG0656	L-ascorbic acid biosynthetic process
GYM62_RS11340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GYM62_RS11345	COG1538	Outer membrane efflux protein
GYM62_RS11355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GYM62_RS11390	COG0473	3-isopropylmalate dehydrogenase activity
GYM62_RS11395	COG1024	Enoyl-CoA hydratase
GYM62_RS11420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GYM62_RS11425	COG0154	amidase activity
GYM62_RS11430	COG1388	LysM domain
GYM62_RS11430	COG0741	lytic transglycosylase activity
GYM62_RS11440	COG0280	phosphate acetyltransferase
GYM62_RS11440	COG0281	malic enzyme
GYM62_RS11445	COG0632	four-way junction helicase activity
GYM62_RS11455	COG0509	glycine decarboxylation via glycine cleavage system
GYM62_RS11475	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GYM62_RS11480	COG1561	YicC-like family, N-terminal region
GYM62_RS11490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYM62_RS11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYM62_RS11500	COG1183	phosphatidylcholine synthase activity
GYM62_RS11520	COG1216	Glycosyl transferase, family 2
GYM62_RS11545	COG1757	Na H antiporter
GYM62_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS11590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GYM62_RS11600	COG0799	negative regulation of ribosome biogenesis
GYM62_RS11605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GYM62_RS11610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GYM62_RS11630	COG4191	Histidine kinase
GYM62_RS11660	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS11660	COG1506	peptidase
GYM62_RS11690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GYM62_RS11710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GYM62_RS11715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GYM62_RS11725	COG0415	Belongs to the DNA photolyase family
GYM62_RS11730	COG1193	negative regulation of DNA recombination
GYM62_RS11740	COG0626	cystathionine gamma-synthase activity
GYM62_RS11760	COG1695	Transcriptional regulator
GYM62_RS11770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYM62_RS11810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GYM62_RS11815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GYM62_RS11910	COG0732	type I restriction modification DNA specificity domain
GYM62_RS11915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GYM62_RS11920	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GYM62_RS11960	COG0523	cobalamin synthesis protein
GYM62_RS11975	COG1476	TRANSCRIPTIONal
GYM62_RS12010	COG0702	epimerase
GYM62_RS12055	COG1131	(ABC) transporter
GYM62_RS12085	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GYM62_RS12105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GYM62_RS12105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GYM62_RS12110	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GYM62_RS12120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS12125	COG1959	2 iron, 2 sulfur cluster binding
GYM62_RS12130	COG3119	arylsulfatase activity
GYM62_RS12150	COG4206	TonB-dependent receptor
GYM62_RS12150	COG1629	transport
GYM62_RS12160	COG1082	Xylose isomerase domain protein TIM barrel
GYM62_RS12195	COG3177	Filamentation induced by cAMP protein fic
GYM62_RS12240	COG4974	Belongs to the 'phage' integrase family
GYM62_RS12280	COG4974	Belongs to the 'phage' integrase family
GYM62_RS12285	COG0582	viral genome integration into host DNA
GYM62_RS12335	COG4974	Belongs to the 'phage' integrase family
GYM62_RS12350	COG1395	domain, Protein
GYM62_RS12375	COG4974	Belongs to the 'phage' integrase family
GYM62_RS12395	COG1395	domain, Protein
GYM62_RS12430	COG0673	inositol 2-dehydrogenase activity
GYM62_RS12480	COG1082	Xylose isomerase domain protein TIM barrel
GYM62_RS12485	COG4948	Mandelate Racemase Muconate Lactonizing
GYM62_RS12495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GYM62_RS12525	COG0659	secondary active sulfate transmembrane transporter activity
GYM62_RS12530	COG0477	Major facilitator Superfamily
GYM62_RS12540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GYM62_RS12560	COG1629	transport
GYM62_RS12585	COG4771	TonB-dependent receptor
GYM62_RS12595	COG0602	queuosine metabolic process
GYM62_RS12605	COG1473	amidohydrolase
GYM62_RS12610	COG0495	leucyl-tRNA aminoacylation
GYM62_RS12660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYM62_RS12660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYM62_RS12690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYM62_RS12705	COG0513	Belongs to the DEAD box helicase family
GYM62_RS12710	COG3239	Fatty acid desaturase
GYM62_RS12720	COG3258	Cytochrome c
GYM62_RS12730	COG2223	nitrite transmembrane transporter activity
GYM62_RS12735	COG0392	lysyltransferase activity
GYM62_RS12750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYM62_RS12750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GYM62_RS12755	COG3118	belongs to the thioredoxin family
GYM62_RS12775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GYM62_RS12785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GYM62_RS12785	COG0517	IMP dehydrogenase activity
GYM62_RS12790	COG0514	ATP-dependent DNA helicase (RecQ)
GYM62_RS12800	COG1774	PSP1 C-terminal conserved region
GYM62_RS12810	COG0166	Belongs to the GPI family
GYM62_RS12820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GYM62_RS12835	COG1127	ABC transporter
GYM62_RS12840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GYM62_RS12860	COG2066	Belongs to the glutaminase family
GYM62_RS12865	COG1217	gtp-binding protein TYPA
GYM62_RS12875	COG0667	Aldo Keto reductase
GYM62_RS12890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GYM62_RS12895	COG0138	bifunctional purine biosynthesis protein purh
GYM62_RS12905	COG1598	PFAM Uncharacterised protein family UPF0150
GYM62_RS12920	COG0215	cysteine-tRNA ligase activity
GYM62_RS12940	COG4654	Cytochrome c, class I
GYM62_RS12970	COG1272	protein, Hemolysin III
GYM62_RS12975	COG2267	carboxylic ester hydrolase activity
GYM62_RS13045	COG2354	Protein conserved in bacteria
GYM62_RS13055	COG0501	Belongs to the peptidase M48B family
GYM62_RS13070	COG3022	response to hydroperoxide
GYM62_RS13120	COG0017	Asparaginyl-tRNA synthetase
GYM62_RS13135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GYM62_RS13135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GYM62_RS13140	COG2270	Major facilitator Superfamily
GYM62_RS13160	COG0811	peptide transport
GYM62_RS13175	COG3250	beta-galactosidase activity
GYM62_RS13180	COG2211	Major facilitator Superfamily
GYM62_RS13185	COG3530	Putative quorum-sensing-regulated virulence factor
GYM62_RS13195	COG3550	peptidyl-serine autophosphorylation
GYM62_RS13200	COG3550	peptidyl-serine autophosphorylation
GYM62_RS13205	COG1396	sequence-specific DNA binding
GYM62_RS13215	COG0252	asparaginase activity
GYM62_RS13220	COG0084	hydrolase, TatD family'
GYM62_RS13245	COG1215	transferase activity, transferring glycosyl groups
GYM62_RS13250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GYM62_RS13280	COG3457	Alanine racemase
GYM62_RS13295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GYM62_RS13300	COG1053	succinate dehydrogenase
GYM62_RS13315	COG3011	Protein conserved in bacteria
GYM62_RS13330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GYM62_RS13340	COG0616	signal peptide processing
GYM62_RS13345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYM62_RS13355	COG0006	proline dipeptidase activity
GYM62_RS13360	COG0612	Peptidase, M16
GYM62_RS13370	COG3103	Sh3 type 3 domain protein
GYM62_RS13370	COG0791	NLP P60 protein
GYM62_RS13370	COG1388	LysM domain
GYM62_RS13380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GYM62_RS13405	COG0577	efflux transmembrane transporter activity
GYM62_RS13405	COG1136	(ABC) transporter
GYM62_RS13410	COG4181	ATPase activity
GYM62_RS13475	COG0733	neurotransmitter:sodium symporter activity
GYM62_RS13490	COG0181	hydroxymethylbilane synthase activity
GYM62_RS13495	COG0189	ligase activity
GYM62_RS13505	COG0470	DNA polymerase III
GYM62_RS13515	COG0254	rRNA binding
GYM62_RS13520	COG2885	chlorophyll binding
GYM62_RS13530	COG1132	(ABC) transporter
GYM62_RS13540	COG0606	chelatase, subunit chli
GYM62_RS13555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GYM62_RS13575	COG1054	Belongs to the UPF0176 family
GYM62_RS13580	COG0626	cystathionine gamma-synthase activity
GYM62_RS13605	COG0101	tRNA pseudouridine synthase activity
GYM62_RS13610	COG1132	(ABC) transporter
GYM62_RS13630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GYM62_RS13640	COG3217	Mosc domain protein beta barrel domain protein
GYM62_RS13640	COG0633	Ferredoxin
GYM62_RS13645	COG0443	Heat shock 70 kDa protein
GYM62_RS13650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GYM62_RS13665	COG0004	ammonium transporteR
GYM62_RS13670	COG0113	porphobilinogen synthase activity
GYM62_RS13680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYM62_RS13690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GYM62_RS13695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GYM62_RS13705	COG0552	protein localization to endoplasmic reticulum
GYM62_RS13735	COG2226	methyltransferase
GYM62_RS13740	COG1216	Glycosyl transferase, family 2
GYM62_RS13745	COG0463	Glycosyl transferase, family 2
GYM62_RS13760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYM62_RS13790	COG0673	inositol 2-dehydrogenase activity
GYM62_RS13795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GYM62_RS13805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYM62_RS13810	COG0248	Ppx GppA phosphatase
GYM62_RS13820	COG0673	inositol 2-dehydrogenase activity
GYM62_RS13830	COG0022	dehydrogenase e1 component
GYM62_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GYM62_RS13870	COG2801	Transposase and inactivated derivatives
GYM62_RS13895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GYM62_RS13900	COG0420	3'-5' exonuclease activity
GYM62_RS13905	COG0419	ATPase involved in DNA repair
GYM62_RS13915	COG0346	lactoylglutathione lyase activity
GYM62_RS13920	COG2353	YceI-like domain
GYM62_RS13950	COG1228	amidohydrolase
GYM62_RS13965	COG0497	DNA recombination
GYM62_RS14000	COG0037	tRNA processing
GYM62_RS14010	COG0039	L-malate dehydrogenase activity
GYM62_RS14020	COG0668	transmembrane transport
GYM62_RS14055	COG1045	serine acetyltransferase
GYM62_RS14070	COG0148	phosphopyruvate hydratase activity
GYM62_RS14075	COG0505	Belongs to the CarA family
GYM62_RS14080	COG0203	ribosomal protein L17
GYM62_RS14085	COG0202	RNA polymerase activity
GYM62_RS14090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GYM62_RS14095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GYM62_RS14100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GYM62_RS14105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GYM62_RS14110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GYM62_RS14120	COG0201	protein transport
GYM62_RS14125	COG0200	Binds to the 23S rRNA
GYM62_RS14130	COG1841	ribosomal large subunit assembly
GYM62_RS14135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GYM62_RS14145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GYM62_RS14150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GYM62_RS14155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GYM62_RS14160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GYM62_RS14165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GYM62_RS14170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GYM62_RS14175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GYM62_RS14180	COG0255	Belongs to the universal ribosomal protein uL29 family
GYM62_RS14185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GYM62_RS14190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GYM62_RS14195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GYM62_RS14200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GYM62_RS14205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GYM62_RS14210	COG0089	rRNA binding
GYM62_RS14215	COG0088	Forms part of the polypeptide exit tunnel
GYM62_RS14220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GYM62_RS14225	COG0051	transcription antitermination factor activity, RNA binding
GYM62_RS14230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GYM62_RS14235	COG0049	tRNA binding
GYM62_RS14240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GYM62_RS14250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GYM62_RS14255	COG0085	RNA polymerase activity
GYM62_RS14260	COG0222	ribosome binding
GYM62_RS14265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GYM62_RS14270	COG0081	regulation of translation
GYM62_RS14275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GYM62_RS14320	COG4770	biotin carboxylase activity
GYM62_RS14325	COG0528	UMP kinase activity
GYM62_RS14330	COG0233	cytoplasmic translational termination
GYM62_RS14340	COG1629	transport
GYM62_RS14345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GYM62_RS14380	COG1373	ATPase (AAA superfamily
GYM62_RS14385	COG0328	RNA-DNA hybrid ribonuclease activity
GYM62_RS14390	COG2095	MarC family integral membrane protein
GYM62_RS14395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GYM62_RS14400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GYM62_RS14405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GYM62_RS14410	COG1629	transport
GYM62_RS14430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GYM62_RS14440	COG1472	Belongs to the glycosyl hydrolase 3 family
GYM62_RS14450	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS14460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS14470	COG4993	Dehydrogenase
GYM62_RS14490	COG4585	Histidine kinase
GYM62_RS14495	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS14505	COG4974	Belongs to the 'phage' integrase family
GYM62_RS14510	COG0242	peptide deformylase activity
GYM62_RS14545	COG0488	(ABC) transporter
GYM62_RS14565	COG2197	response regulator
GYM62_RS14580	COG1054	Belongs to the UPF0176 family
GYM62_RS14605	COG0284	orotidine-5'-phosphate decarboxylase activity
GYM62_RS14620	COG0463	Glycosyl transferase, family 2
GYM62_RS14640	COG4974	Belongs to the 'phage' integrase family
GYM62_RS14645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GYM62_RS14655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GYM62_RS14665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYM62_RS14675	COG3720	iron ion transport
GYM62_RS14690	COG0791	NLP P60 protein
GYM62_RS14705	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS14705	COG1506	peptidase
GYM62_RS14710	COG1181	Belongs to the D-alanine--D-alanine ligase family
GYM62_RS14715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GYM62_RS14730	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS14740	COG2755	lipolytic protein G-D-S-L family
GYM62_RS14740	COG0657	acetylesterase activity
GYM62_RS14745	COG3548	integral membrane protein
GYM62_RS14760	COG1525	nuclease
GYM62_RS14765	COG0330	HflC and HflK could
GYM62_RS14770	COG0330	HflC and HflK could
GYM62_RS14795	COG4771	TonB-dependent receptor
GYM62_RS14910	COG0464	growth
GYM62_RS14920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GYM62_RS14940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYM62_RS14975	COG0739	heme binding
GYM62_RS15095	COG1192	Involved in chromosome partitioning
GYM62_RS15115	COG1752	Esterase of the alpha-beta hydrolase superfamily
GYM62_RS15125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GYM62_RS15135	COG1309	transcriptional regulator
GYM62_RS15150	COG3384	dioxygenase
GYM62_RS15155	COG0702	epimerase
GYM62_RS15205	COG4974	Belongs to the 'phage' integrase family
GYM62_RS15245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GYM62_RS15250	COG1160	GTP binding
GYM62_RS15265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GYM62_RS15270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GYM62_RS15290	COG2801	Transposase and inactivated derivatives
GYM62_RS15300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GYM62_RS15325	COG0308	aminopeptidase N
GYM62_RS15330	COG0456	acetyltransferase
GYM62_RS15345	COG0295	cytidine deaminase activity
GYM62_RS15370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GYM62_RS15375	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GYM62_RS15380	COG2807	transmembrane transport
GYM62_RS15385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GYM62_RS15390	COG0475	glutathione-regulated potassium exporter activity
GYM62_RS15490	COG0247	lactate metabolic process
GYM62_RS15490	COG2181	nitrate reductase activity
GYM62_RS15495	COG0247	lactate metabolic process
GYM62_RS15495	COG2181	nitrate reductase activity
GYM62_RS15505	COG2885	chlorophyll binding
GYM62_RS15525	COG2852	Protein conserved in bacteria
GYM62_RS15540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GYM62_RS15545	COG2226	methyltransferase
GYM62_RS15555	COG4221	oxidoreductase activity
GYM62_RS15565	COG0167	dihydroorotate dehydrogenase activity
GYM62_RS15570	COG1674	ftsk spoiiie
GYM62_RS15580	COG0512	Glutamine amidotransferase of anthranilate synthase
GYM62_RS15590	COG1610	YqeY-like protein
GYM62_RS15595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GYM62_RS15600	COG0596	Alpha beta hydrolase
GYM62_RS15605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GYM62_RS15615	COG1404	Belongs to the peptidase S8 family
GYM62_RS15625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GYM62_RS15655	COG3344	reverse transcriptase
GYM62_RS15665	COG0228	four-way junction DNA binding
GYM62_RS15670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GYM62_RS15675	COG0336	Belongs to the RNA methyltransferase TrmD family
GYM62_RS15680	COG0335	large ribosomal subunit rRNA binding
GYM62_RS15685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GYM62_RS15685	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GYM62_RS15715	COG4206	TonB-dependent receptor
GYM62_RS15715	COG1629	transport
GYM62_RS15735	COG1131	(ABC) transporter
GYM62_RS15745	COG1917	Cupin 2, conserved barrel domain protein
GYM62_RS15745	COG4977	sequence-specific DNA binding
GYM62_RS15750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYM62_RS15760	COG3938	Belongs to the proline racemase family
GYM62_RS15765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYM62_RS15775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GYM62_RS15780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GYM62_RS15785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GYM62_RS15790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GYM62_RS15795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GYM62_RS15800	COG0356	it plays a direct role in the translocation of protons across the membrane
GYM62_RS15825	COG0322	excinuclease ABC activity
GYM62_RS15845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYM62_RS15870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GYM62_RS15885	COG1366	Belongs to the anti-sigma-factor antagonist family
GYM62_RS15895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GYM62_RS15900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GYM62_RS15910	COG1132	(ABC) transporter
GYM62_RS15920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GYM62_RS15935	COG1862	Preprotein translocase
GYM62_RS15965	COG0450	alkyl hydroperoxide reductase
GYM62_RS15970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GYM62_RS15995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GYM62_RS16005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GYM62_RS16025	COG3118	belongs to the thioredoxin family
GYM62_RS16035	COG1187	pseudouridine synthase activity
GYM62_RS16040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GYM62_RS16065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GYM62_RS16070	COG1966	Carbon starvation protein
GYM62_RS16090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GYM62_RS16090	COG5180	pathogenesis
GYM62_RS16095	COG0195	Participates in both transcription termination and antitermination
GYM62_RS16095	COG2251	uridine kinase activity
GYM62_RS16100	COG0779	Required for maturation of 30S ribosomal subunits
GYM62_RS16105	COG1077	Cell shape determining protein MreB Mrl
GYM62_RS16120	COG0768	penicillin binding
GYM62_RS16125	COG0772	Belongs to the SEDS family
GYM62_RS16145	COG1381	Involved in DNA repair and RecF pathway recombination
GYM62_RS16150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GYM62_RS16175	COG0564	pseudouridine synthase activity
GYM62_RS16180	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GYM62_RS16190	COG0556	nucleotide-excision repair
GYM62_RS16205	COG2610	gluconate transmembrane transporter activity
GYM62_RS16215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GYM62_RS16225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GYM62_RS16235	COG0596	Alpha beta hydrolase
GYM62_RS16250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GYM62_RS16255	COG0739	heme binding
GYM62_RS16265	COG1187	pseudouridine synthase activity
GYM62_RS16270	COG2885	chlorophyll binding
GYM62_RS16300	COG2885	chlorophyll binding
GYM62_RS16320	COG0657	acetylesterase activity
GYM62_RS16330	COG1595	DNA-templated transcription, initiation
GYM62_RS16350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GYM62_RS16355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GYM62_RS16365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GYM62_RS16390	COG0668	transmembrane transport
GYM62_RS16400	COG3424	synthase
GYM62_RS16410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYM62_RS16435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS16440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GYM62_RS16485	COG0714	Associated with various cellular activities
GYM62_RS16490	COG1187	pseudouridine synthase activity
GYM62_RS16515	COG1473	amidohydrolase
GYM62_RS16535	COG0702	epimerase
GYM62_RS16540	COG4771	TonB-dependent receptor
GYM62_RS16575	COG1132	(ABC) transporter
GYM62_RS16595	COG4591	ABC-type transport system involved in lipoprotein release permease component
GYM62_RS16600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GYM62_RS16610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GYM62_RS16620	COG0572	uridine kinase
GYM62_RS16625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GYM62_RS16650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GYM62_RS16655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GYM62_RS16660	COG0363	glucosamine-6-phosphate deaminase activity
GYM62_RS16665	COG1064	alcohol dehydrogenase
GYM62_RS16695	COG2801	Transposase and inactivated derivatives
GYM62_RS16715	COG2255	four-way junction helicase activity
GYM62_RS16720	COG1477	protein flavinylation
GYM62_RS16735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYM62_RS16740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYM62_RS16770	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GYM62_RS16775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GYM62_RS16780	COG0698	ribose 5-phosphate isomerase
GYM62_RS16785	COG0805	protein transport
GYM62_RS16790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GYM62_RS16805	COG3344	reverse transcriptase
GYM62_RS16815	COG0679	Auxin Efflux Carrier
GYM62_RS16820	COG0483	inositol monophosphate 1-phosphatase activity
GYM62_RS16825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GYM62_RS16830	COG2154	pterin-4-alpha-carbinolamine dehydratase
GYM62_RS16870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GYM62_RS16880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYM62_RS16895	COG0519	Catalyzes the synthesis of GMP from XMP
GYM62_RS16905	COG0788	formyltetrahydrofolate deformylase activity
GYM62_RS16910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GYM62_RS16920	COG1809	phosphosulfolactate synthase activity
GYM62_RS16930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYM62_RS16935	COG4464	protein tyrosine phosphatase activity
GYM62_RS16940	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GYM62_RS16945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GYM62_RS16950	COG5002	protein histidine kinase activity
GYM62_RS16995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GYM62_RS17000	COG0598	Magnesium transport protein CorA
GYM62_RS17005	COG0157	Belongs to the NadC ModD family
GYM62_RS17015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GYM62_RS17050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GYM62_RS17050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GYM62_RS17055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GYM62_RS17060	COG2801	Transposase and inactivated derivatives
GYM62_RS17085	COG0076	glutamate decarboxylase activity
GYM62_RS17090	COG1506	peptidase
GYM62_RS17090	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS17115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GYM62_RS17135	COG1595	DNA-templated transcription, initiation
GYM62_RS17160	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GYM62_RS17205	COG2826	transposase and inactivated derivatives, IS30 family
GYM62_RS17220	COG2860	membrane
GYM62_RS17225	COG2226	methyltransferase
GYM62_RS17240	COG0156	8-amino-7-oxononanoate synthase activity
GYM62_RS17250	COG0415	Belongs to the DNA photolyase family
GYM62_RS17270	COG0432	Pfam Uncharacterised protein family UPF0047
GYM62_RS17290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GYM62_RS17290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GYM62_RS17300	COG4585	Histidine kinase
GYM62_RS17310	COG1473	amidohydrolase
GYM62_RS17320	COG0653	protein targeting
GYM62_RS17325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GYM62_RS17330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GYM62_RS17345	COG0668	transmembrane transport
GYM62_RS17375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GYM62_RS17395	COG2197	response regulator
GYM62_RS17400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GYM62_RS17420	COG2801	Transposase and inactivated derivatives
GYM62_RS17450	COG1040	competence protein
GYM62_RS17465	COG0708	Exodeoxyribonuclease III
GYM62_RS17475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GYM62_RS17480	COG0445	tRNA wobble uridine modification
GYM62_RS17485	COG2226	methyltransferase
GYM62_RS17495	COG1022	Amp-dependent synthetase and ligase
GYM62_RS17505	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYM62_RS17505	COG1024	Enoyl-CoA hydratase
GYM62_RS17515	COG0183	Belongs to the thiolase family
GYM62_RS17520	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS17545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GYM62_RS17545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GYM62_RS17550	COG1956	GAF domain-containing protein
GYM62_RS17565	COG0662	Cupin 2, conserved barrel domain protein
GYM62_RS17570	COG3844	kynureninase activity
GYM62_RS17575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYM62_RS17595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYM62_RS17605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GYM62_RS17635	COG0154	amidase activity
GYM62_RS17650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GYM62_RS17655	COG0367	asparagine synthase
GYM62_RS17700	COG1073	alpha beta
GYM62_RS17700	COG2226	methyltransferase
GYM62_RS17720	COG3023	N-Acetylmuramoyl-L-alanine amidase
GYM62_RS17765	COG4206	TonB-dependent receptor
GYM62_RS17765	COG1629	transport
GYM62_RS17805	COG0653	protein targeting
GYM62_RS17910	COG3620	sequence-specific DNA binding
GYM62_RS17925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GYM62_RS17950	COG3956	TIGRFAM MazG family protein
GYM62_RS17960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GYM62_RS17965	COG1104	cysteine desulfurase activity
GYM62_RS18025	COG0423	glycine-tRNA ligase activity
GYM62_RS18050	COG0423	glycine-tRNA ligase activity
GYM62_RS18075	COG0149	triose-phosphate isomerase activity
GYM62_RS18080	COG2264	protein methyltransferase activity
GYM62_RS18085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GYM62_RS18085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GYM62_RS18090	COG1137	ATPase activity
GYM62_RS18105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GYM62_RS18115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GYM62_RS18125	COG3622	Belongs to the hyi family
GYM62_RS18130	COG0673	inositol 2-dehydrogenase activity
GYM62_RS18135	COG0515	serine threonine protein kinase
GYM62_RS18135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYM62_RS18150	COG0626	cystathionine gamma-synthase activity
GYM62_RS18160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GYM62_RS18170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GYM62_RS18180	COG0297	glycogen (starch) synthase activity
GYM62_RS18185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GYM62_RS18190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GYM62_RS18205	COG1960	acyl-CoA dehydrogenase activity
GYM62_RS18210	COG1917	Cupin 2, conserved barrel domain protein
GYM62_RS18210	COG4977	sequence-specific DNA binding
GYM62_RS18215	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GYM62_RS18235	COG1611	Belongs to the LOG family
GYM62_RS18245	COG0516	GMP reductase activity
GYM62_RS18245	COG0517	IMP dehydrogenase activity
GYM62_RS18255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GYM62_RS18265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GYM62_RS18270	COG0673	inositol 2-dehydrogenase activity
GYM62_RS18275	COG2197	response regulator
GYM62_RS18280	COG4585	Histidine kinase
GYM62_RS18300	COG1138	Cytochrome C-type biogenesis protein
GYM62_RS18325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GYM62_RS18335	COG0004	ammonium transporteR
GYM62_RS18360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GYM62_RS18365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GYM62_RS18375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GYM62_RS18380	COG0527	aspartate kinase activity
GYM62_RS18390	COG1764	response to oxidative stress
GYM62_RS18400	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GYM62_RS18420	COG4948	Mandelate Racemase Muconate Lactonizing
GYM62_RS18455	COG3046	protein related to deoxyribodipyrimidine photolyase
GYM62_RS18535	COG1764	response to oxidative stress
GYM62_RS18540	COG1846	Transcriptional regulator
GYM62_RS18545	COG3118	belongs to the thioredoxin family
GYM62_RS18550	COG0673	inositol 2-dehydrogenase activity
GYM62_RS18555	COG0583	DNA-binding transcription factor activity
GYM62_RS18560	COG3015	lipoprotein NlpE involved in copper resistance
GYM62_RS18600	COG4771	TonB-dependent receptor
GYM62_RS18605	COG1968	undecaprenyl-diphosphatase activity
GYM62_RS18625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYM62_RS18630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GYM62_RS18635	COG1845	cytochrome c oxidase, subunit III
GYM62_RS18655	COG1704	LemA family
GYM62_RS18670	COG0105	UTP biosynthetic process
GYM62_RS18675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GYM62_RS18680	COG0545	Peptidyl-prolyl cis-trans isomerase
GYM62_RS18705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GYM62_RS18710	COG1283	sodium-dependent phosphate transmembrane transporter activity
GYM62_RS18720	COG0590	tRNA wobble adenosine to inosine editing
GYM62_RS18765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYM62_RS18790	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GYM62_RS18795	COG0217	transcriptional regulatory protein
GYM62_RS18800	COG1252	NADH dehydrogenase
GYM62_RS18815	COG0067	glutamate synthase
GYM62_RS18815	COG0069	glutamate synthase activity
GYM62_RS18815	COG0070	glutamate synthase
GYM62_RS18825	COG0629	single-stranded DNA binding
GYM62_RS18835	COG0776	regulation of translation
GYM62_RS18845	COG1530	ribonuclease E activity
GYM62_RS18860	COG3279	Response regulator of the LytR AlgR family
GYM62_RS18865	COG2972	Histidine kinase
GYM62_RS18875	COG4771	TonB-dependent receptor
GYM62_RS18905	COG1090	epimerase
GYM62_RS18910	COG0038	chloride channel
GYM62_RS18915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYM62_RS18920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GYM62_RS18935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYM62_RS18940	COG0596	Alpha beta hydrolase
GYM62_RS18945	COG2890	protein-(glutamine-N5) methyltransferase activity
GYM62_RS18955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GYM62_RS18955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GYM62_RS18965	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
GYM62_RS18980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GYM62_RS18985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GYM62_RS18990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GYM62_RS18995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GYM62_RS19075	COG0517	IMP dehydrogenase activity
GYM62_RS19080	COG4974	Belongs to the 'phage' integrase family
GYM62_RS19085	COG3344	reverse transcriptase
GYM62_RS19095	COG0583	DNA-binding transcription factor activity
GYM62_RS19100	COG0753	catalase activity
GYM62_RS19110	COG4974	Belongs to the 'phage' integrase family
GYM62_RS19130	COG0784	Response regulator, receiver
GYM62_RS19135	COG3279	Response regulator of the LytR AlgR family
GYM62_RS19145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GYM62_RS19150	COG0346	lactoylglutathione lyase activity
GYM62_RS19220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GYM62_RS19255	COG0084	hydrolase, TatD family'
GYM62_RS19265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GYM62_RS19285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GYM62_RS19290	COG4946	Tricorn protease homolog
GYM62_RS19290	COG0793	Belongs to the peptidase S41A family
GYM62_RS19315	COG0793	Belongs to the peptidase S41A family
GYM62_RS19315	COG4946	Tricorn protease homolog
GYM62_RS19320	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS19355	COG3279	Response regulator of the LytR AlgR family
GYM62_RS19370	COG3292	Two component regulator propeller
GYM62_RS19370	COG2205	protein histidine kinase activity
GYM62_RS19370	COG0745	RESPONSE REGULATOR receiver
GYM62_RS19395	COG5002	protein histidine kinase activity
GYM62_RS19410	COG4191	Histidine kinase
GYM62_RS19460	COG2072	flavoprotein involved in K transport
GYM62_RS19465	COG3961	Belongs to the TPP enzyme family
GYM62_RS19475	COG3852	Histidine kinase
GYM62_RS19485	COG4946	Tricorn protease homolog
GYM62_RS19485	COG0823	Involved in the tonB-independent uptake of proteins
GYM62_RS19485	COG1506	peptidase
GYM62_RS19490	COG0531	amino acid
GYM62_RS19510	COG3119	arylsulfatase activity
GYM62_RS19550	COG0326	Molecular chaperone. Has ATPase activity
GYM62_RS19575	COG2801	Transposase and inactivated derivatives
GYM62_RS19580	COG1959	2 iron, 2 sulfur cluster binding
GYM62_RS19590	COG0175	sulfate reduction
GYM62_RS19595	COG0175	sulfate reduction
GYM62_RS19600	COG2895	sulfate adenylyltransferase (ATP) activity
GYM62_RS19605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GYM62_RS19615	COG1648	precorrin-2 dehydrogenase activity
GYM62_RS19615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GYM62_RS19640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GYM62_RS19645	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GYM62_RS19655	COG3387	PFAM Glycoside hydrolase 15-related
GYM62_RS19675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GYM62_RS19680	COG0194	GDP metabolic process
GYM62_RS19690	COG1595	DNA-templated transcription, initiation
GYM62_RS19710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GYM62_RS19715	COG0129	dihydroxy-acid dehydratase activity
GYM62_RS19720	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS19780	COG1523	belongs to the glycosyl hydrolase 13 family
GYM62_RS19810	COG3119	arylsulfatase activity
GYM62_RS19865	COG1595	DNA-templated transcription, initiation
GYM62_RS19890	COG4628	conserved protein (DUF2132)
GYM62_RS19905	COG0592	DNA-directed DNA polymerase activity
GYM62_RS19920	COG1131	(ABC) transporter
GYM62_RS19925	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS19930	COG1473	amidohydrolase
GYM62_RS19935	COG1473	amidohydrolase
GYM62_RS19940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GYM62_RS19945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYM62_RS19950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GYM62_RS19955	COG1349	DNA-binding transcription factor activity
GYM62_RS19965	COG0564	pseudouridine synthase activity
GYM62_RS19975	COG0492	ferredoxin-NADP+ reductase activity
GYM62_RS19985	COG1902	pentaerythritol trinitrate reductase activity
GYM62_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS20005	COG2001	Belongs to the MraZ family
GYM62_RS20010	COG0275	rRNA processing
GYM62_RS20020	COG0768	penicillin binding
GYM62_RS20025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GYM62_RS20030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GYM62_RS20035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GYM62_RS20040	COG0772	Belongs to the SEDS family
GYM62_RS20045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GYM62_RS20050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GYM62_RS20065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GYM62_RS20100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GYM62_RS20115	COG0697	spore germination
GYM62_RS20120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GYM62_RS20140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYM62_RS20145	COG0688	phosphatidylethanolamine metabolic process
GYM62_RS20165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GYM62_RS20170	COG0612	Peptidase, M16
GYM62_RS20175	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GYM62_RS20180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GYM62_RS20190	COG1629	transport
GYM62_RS20265	COG0542	response to heat
GYM62_RS20275	COG0259	pyridoxamine-phosphate oxidase activity
GYM62_RS20290	COG0589	response to stress
GYM62_RS20290	COG0475	glutathione-regulated potassium exporter activity
GYM62_RS20305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GYM62_RS20390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GYM62_RS20400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GYM62_RS20415	COG0561	phosphatase activity
GYM62_RS20440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GYM62_RS20450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYM62_RS20465	COG1028	Short-chain dehydrogenase reductase Sdr
GYM62_RS20480	COG0460	homoserine dehydrogenase
GYM62_RS20480	COG0527	aspartate kinase activity
GYM62_RS20485	COG0083	homoserine kinase activity
GYM62_RS20490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GYM62_RS20495	COG3177	Filamentation induced by cAMP protein fic
GYM62_RS20530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GYM62_RS20540	COG2133	pyrroloquinoline quinone binding
GYM62_RS20550	COG0527	aspartate kinase activity
GYM62_RS20555	COG0673	inositol 2-dehydrogenase activity
GYM62_RS20565	COG3001	Fructosamine kinase
GYM62_RS20570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GYM62_RS20590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GYM62_RS20600	COG0297	glycogen (starch) synthase activity
GYM62_RS20625	COG0513	Belongs to the DEAD box helicase family
GYM62_RS20635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GYM62_RS20635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GYM62_RS20645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GYM62_RS20645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GYM62_RS20650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GYM62_RS20655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GYM62_RS20660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GYM62_RS20685	COG0142	geranyltranstransferase activity
GYM62_RS20690	COG0557	exoribonuclease II activity
GYM62_RS20705	COG0321	lipoyl(octanoyl) transferase activity
GYM62_RS20710	COG0792	nuclease activity
GYM62_RS20735	COG1215	transferase activity, transferring glycosyl groups
GYM62_RS20750	COG0693	protein deglycase activity
GYM62_RS20795	COG0793	Belongs to the peptidase S41A family
GYM62_RS20805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GYM62_RS20810	COG0242	peptide deformylase activity
GYM62_RS20815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYM62_RS20835	COG3279	Response regulator of the LytR AlgR family
GYM62_RS20840	COG2972	Histidine kinase
GYM62_RS20910	COG0673	inositol 2-dehydrogenase activity
GYM62_RS20915	COG2211	Major facilitator Superfamily
GYM62_RS20920	COG1082	Xylose isomerase domain protein TIM barrel
GYM62_RS20965	COG0438	transferase activity, transferring glycosyl groups
GYM62_RS21020	COG2226	methyltransferase
GYM62_RS21025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYM62_RS21065	COG2197	response regulator