locus-tag	class	description
ID165_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ID165_RS00020	COG4771	TonB-dependent receptor
ID165_RS00030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID165_RS00035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ID165_RS00050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID165_RS00080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ID165_RS00080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ID165_RS00130	COG0793	Belongs to the peptidase S41A family
ID165_RS00140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ID165_RS00145	COG0242	peptide deformylase activity
ID165_RS00215	COG4654	Cytochrome c, class I
ID165_RS00225	COG0673	inositol 2-dehydrogenase activity
ID165_RS00230	COG2211	Major facilitator Superfamily
ID165_RS00235	COG1082	Xylose isomerase domain protein TIM barrel
ID165_RS00270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ID165_RS00280	COG0006	proline dipeptidase activity
ID165_RS00300	COG1011	Hydrolase
ID165_RS00305	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS00325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID165_RS00330	COG1595	DNA-templated transcription, initiation
ID165_RS00345	COG0584	glycerophosphoryl diester phosphodiesterase
ID165_RS00360	COG0363	glucosamine-6-phosphate deaminase activity
ID165_RS00365	COG3265	gluconokinase activity
ID165_RS00375	COG2017	converts alpha-aldose to the beta-anomer
ID165_RS00385	COG1472	Belongs to the glycosyl hydrolase 3 family
ID165_RS00390	COG2211	Major facilitator Superfamily
ID165_RS00405	COG1649	PFAM Uncharacterised BCR, COG1649
ID165_RS00415	COG1349	DNA-binding transcription factor activity
ID165_RS00435	COG1473	amidohydrolase
ID165_RS00440	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID165_RS00470	COG2378	regulation of single-species biofilm formation
ID165_RS00485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ID165_RS00500	COG4771	TonB-dependent receptor
ID165_RS00505	COG0702	epimerase
ID165_RS00510	COG1785	Belongs to the alkaline phosphatase family
ID165_RS00510	COG1785	Belongs to the alkaline phosphatase family
ID165_RS00520	COG3263	regulation of cellular component size
ID165_RS00530	COG0702	epimerase
ID165_RS00535	COG1629	transport
ID165_RS00545	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS00545	COG1506	peptidase
ID165_RS00545	COG4946	Tricorn protease homolog
ID165_RS00665	COG1131	(ABC) transporter
ID165_RS00675	COG1725	Transcriptional regulator
ID165_RS00685	COG0251	oxidation-reduction process
ID165_RS00690	COG0456	acetyltransferase
ID165_RS00690	COG0454	-acetyltransferase
ID165_RS00700	COG1196	nuclear chromosome segregation
ID165_RS00700	COG3264	Mechanosensitive ion channel
ID165_RS00705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID165_RS00705	COG3153	acetyltransferase
ID165_RS00710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ID165_RS00715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ID165_RS00740	COG0302	gtp cyclohydrolase
ID165_RS00750	COG5002	protein histidine kinase activity
ID165_RS00750	COG2198	Histidine kinase
ID165_RS00750	COG0784	Response regulator, receiver
ID165_RS00765	COG1595	DNA-templated transcription, initiation
ID165_RS00780	COG1136	(ABC) transporter
ID165_RS00780	COG0577	efflux transmembrane transporter activity
ID165_RS00790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ID165_RS00800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ID165_RS00805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ID165_RS00815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ID165_RS00865	COG1858	cytochrome C peroxidase
ID165_RS00885	COG1609	Transcriptional regulator
ID165_RS00890	COG1629	transport
ID165_RS00890	COG4206	TonB-dependent receptor
ID165_RS00895	COG0702	epimerase
ID165_RS00910	COG3507	Belongs to the glycosyl hydrolase 43 family
ID165_RS00910	COG3693	PFAM glycoside hydrolase, family 10
ID165_RS00910	COG2382	esterase
ID165_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS00920	COG1063	alcohol dehydrogenase
ID165_RS00935	COG0745	RESPONSE REGULATOR receiver
ID165_RS00935	COG3292	Two component regulator propeller
ID165_RS00935	COG2205	protein histidine kinase activity
ID165_RS00940	COG4771	TonB-dependent receptor
ID165_RS00945	COG0561	phosphatase activity
ID165_RS00955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ID165_RS00960	COG3250	beta-galactosidase activity
ID165_RS00965	COG2909	trisaccharide binding
ID165_RS00975	COG4774	siderophore transport
ID165_RS00985	COG3279	Response regulator of the LytR AlgR family
ID165_RS00990	COG3275	phosphorelay sensor kinase activity
ID165_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS01040	COG1309	transcriptional regulator
ID165_RS01050	COG3604	Transcriptional regulator
ID165_RS01060	COG3920	Histidine kinase
ID165_RS01075	COG3604	Transcriptional regulator
ID165_RS01085	COG3781	membrane
ID165_RS01100	COG1335	isochorismatase
ID165_RS01125	COG1764	response to oxidative stress
ID165_RS01145	COG0778	Nitroreductase
ID165_RS01150	COG0683	leucine binding
ID165_RS01155	COG1741	Belongs to the pirin family
ID165_RS01170	COG1335	isochorismatase
ID165_RS01180	COG2353	YceI-like domain
ID165_RS01200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ID165_RS01200	COG0475	glutathione-regulated potassium exporter activity
ID165_RS01210	COG0492	ferredoxin-NADP+ reductase activity
ID165_RS01230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID165_RS01235	COG0596	Alpha beta hydrolase
ID165_RS01265	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS01275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ID165_RS01290	COG1228	amidohydrolase
ID165_RS01305	COG3279	Response regulator of the LytR AlgR family
ID165_RS01330	COG3275	phosphorelay sensor kinase activity
ID165_RS01335	COG3279	Response regulator of the LytR AlgR family
ID165_RS01400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ID165_RS01500	COG4771	TonB-dependent receptor
ID165_RS01545	COG1131	(ABC) transporter
ID165_RS01550	COG2972	Histidine kinase
ID165_RS01560	COG1733	regulation of RNA biosynthetic process
ID165_RS01565	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID165_RS01605	COG1629	transport
ID165_RS01610	COG0702	epimerase
ID165_RS01615	COG0584	glycerophosphoryl diester phosphodiesterase
ID165_RS01640	COG1629	transport
ID165_RS01650	COG0405	Gamma-glutamyltransferase
ID165_RS01675	COG2271	Major facilitator Superfamily
ID165_RS01705	COG2204	response regulator
ID165_RS01720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ID165_RS01725	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ID165_RS01730	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ID165_RS01740	COG2205	protein histidine kinase activity
ID165_RS01745	COG5002	protein histidine kinase activity
ID165_RS01750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ID165_RS01755	COG0569	domain protein
ID165_RS01775	COG0584	glycerophosphoryl diester phosphodiesterase
ID165_RS01790	COG1629	transport
ID165_RS01790	COG4206	TonB-dependent receptor
ID165_RS01855	COG2003	Belongs to the UPF0758 family
ID165_RS01880	COG3279	Response regulator of the LytR AlgR family
ID165_RS01905	COG4977	sequence-specific DNA binding
ID165_RS01960	COG2267	carboxylic ester hydrolase activity
ID165_RS01990	COG3279	Response regulator of the LytR AlgR family
ID165_RS01995	COG2972	Histidine kinase
ID165_RS02025	COG3275	phosphorelay sensor kinase activity
ID165_RS02030	COG3279	Response regulator of the LytR AlgR family
ID165_RS02090	COG0346	lactoylglutathione lyase activity
ID165_RS02095	COG2003	Belongs to the UPF0758 family
ID165_RS02135	COG2003	Belongs to the UPF0758 family
ID165_RS02145	COG2267	carboxylic ester hydrolase activity
ID165_RS02240	COG4221	oxidoreductase activity
ID165_RS02260	COG0450	alkyl hydroperoxide reductase
ID165_RS02325	COG1741	Belongs to the pirin family
ID165_RS02340	COG1902	pentaerythritol trinitrate reductase activity
ID165_RS02350	COG2801	Transposase and inactivated derivatives
ID165_RS02670	COG1595	DNA-templated transcription, initiation
ID165_RS02680	COG4771	TonB-dependent receptor
ID165_RS02700	COG0673	inositol 2-dehydrogenase activity
ID165_RS02705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID165_RS02735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS02740	COG1136	(ABC) transporter
ID165_RS02745	COG0577	efflux transmembrane transporter activity
ID165_RS02745	COG1136	(ABC) transporter
ID165_RS02750	COG3275	phosphorelay sensor kinase activity
ID165_RS02755	COG3279	Response regulator of the LytR AlgR family
ID165_RS02770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID165_RS02790	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ID165_RS02830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID165_RS02840	COG0009	L-threonylcarbamoyladenylate synthase
ID165_RS02850	COG0542	response to heat
ID165_RS02855	COG1595	DNA-templated transcription, initiation
ID165_RS02880	COG1796	DNA polymerase
ID165_RS02880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ID165_RS02895	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ID165_RS02900	COG0540	Belongs to the ATCase OTCase family
ID165_RS02905	COG1131	(ABC) transporter
ID165_RS02945	COG0463	Glycosyl transferase, family 2
ID165_RS02960	COG3186	Phenylalanine-4-hydroxylase
ID165_RS02965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ID165_RS02970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ID165_RS02975	COG0107	imidazoleglycerol-phosphate synthase activity
ID165_RS02980	COG0140	phosphoribosyl-ATP diphosphatase activity
ID165_RS02980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ID165_RS02995	COG0667	Aldo Keto reductase
ID165_RS03005	COG1217	gtp-binding protein TYPA
ID165_RS03010	COG3537	Alpha-1,2-mannosidase
ID165_RS03015	COG2066	Belongs to the glutaminase family
ID165_RS03035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ID165_RS03040	COG1127	ABC transporter
ID165_RS03055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ID165_RS03110	COG0640	Transcriptional regulator
ID165_RS03130	COG1733	regulation of RNA biosynthetic process
ID165_RS03135	COG0702	epimerase
ID165_RS03150	COG0640	Transcriptional regulator
ID165_RS03165	COG0798	PFAM Bile acid sodium symporter
ID165_RS03170	COG2072	flavoprotein involved in K transport
ID165_RS03180	COG1595	DNA-templated transcription, initiation
ID165_RS03200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID165_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS03215	COG2318	DinB family
ID165_RS03220	COG2207	Transcriptional regulator
ID165_RS03230	COG4771	TonB-dependent receptor
ID165_RS03250	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS03255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ID165_RS03260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID165_RS03265	COG1069	ribulokinase activity
ID165_RS03270	COG1271	oxidase subunit
ID165_RS03300	COG0577	efflux transmembrane transporter activity
ID165_RS03300	COG1136	(ABC) transporter
ID165_RS03320	COG1136	(ABC) transporter
ID165_RS03320	COG0577	efflux transmembrane transporter activity
ID165_RS03325	COG0577	efflux transmembrane transporter activity
ID165_RS03380	COG0577	efflux transmembrane transporter activity
ID165_RS03420	COG0577	efflux transmembrane transporter activity
ID165_RS03420	COG1136	(ABC) transporter
ID165_RS03425	COG1136	(ABC) transporter
ID165_RS03425	COG0577	efflux transmembrane transporter activity
ID165_RS03445	COG1555	photosystem II stabilization
ID165_RS03450	COG1785	Belongs to the alkaline phosphatase family
ID165_RS03455	COG0523	cobalamin synthesis protein
ID165_RS03460	COG0523	cobalamin synthesis protein
ID165_RS03470	COG1136	(ABC) transporter
ID165_RS03485	COG4251	negative regulation of phosphorylation
ID165_RS03505	COG5002	protein histidine kinase activity
ID165_RS03515	COG2198	Histidine kinase
ID165_RS03515	COG0784	Response regulator, receiver
ID165_RS03515	COG2205	protein histidine kinase activity
ID165_RS03515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID165_RS03525	COG0745	RESPONSE REGULATOR receiver
ID165_RS03560	COG1203	CRISPR-associated helicase, Cas3
ID165_RS03580	COG1518	maintenance of DNA repeat elements
ID165_RS03585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ID165_RS03740	COG4654	Cytochrome c, class I
ID165_RS03775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ID165_RS03780	COG4948	Mandelate Racemase Muconate Lactonizing
ID165_RS03785	COG2706	6-phosphogluconolactonase activity
ID165_RS03790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ID165_RS03805	COG2133	pyrroloquinoline quinone binding
ID165_RS03915	COG2388	GCN5-related N-acetyl-transferase
ID165_RS03930	COG1228	amidohydrolase
ID165_RS03945	COG0459	protein refolding
ID165_RS03950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ID165_RS03980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID165_RS03985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID165_RS04000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ID165_RS04005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ID165_RS04010	COG1051	belongs to the nudix hydrolase family
ID165_RS04015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ID165_RS04035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID165_RS04045	COG1733	regulation of RNA biosynthetic process
ID165_RS04050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID165_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04080	COG2378	regulation of single-species biofilm formation
ID165_RS04125	COG0517	IMP dehydrogenase activity
ID165_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04145	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID165_RS04155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS04175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ID165_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04190	COG3781	membrane
ID165_RS04205	COG4974	Belongs to the 'phage' integrase family
ID165_RS04210	COG1132	(ABC) transporter
ID165_RS04225	COG2755	lipolytic protein G-D-S-L family
ID165_RS04225	COG0657	acetylesterase activity
ID165_RS04235	COG0738	Major facilitator superfamily
ID165_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04250	COG0179	Fumarylacetoacetate (FAA) hydrolase
ID165_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04260	COG0673	inositol 2-dehydrogenase activity
ID165_RS04265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ID165_RS04270	COG3850	Histidine kinase
ID165_RS04270	COG5002	protein histidine kinase activity
ID165_RS04290	COG1309	transcriptional regulator
ID165_RS04320	COG0024	Methionine aminopeptidase
ID165_RS04330	COG1115	amino acid carrier protein
ID165_RS04340	COG0673	inositol 2-dehydrogenase activity
ID165_RS04420	COG1086	Polysaccharide biosynthesis protein
ID165_RS04425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID165_RS04430	COG1083	cytidylyl-transferase
ID165_RS04450	COG2089	acid synthase
ID165_RS04460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS04505	COG1216	Glycosyl transferase, family 2
ID165_RS04520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ID165_RS04555	COG0463	Glycosyl transferase, family 2
ID165_RS04560	COG0438	transferase activity, transferring glycosyl groups
ID165_RS04570	COG0438	transferase activity, transferring glycosyl groups
ID165_RS04575	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ID165_RS04610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID165_RS04660	COG0463	Glycosyl transferase, family 2
ID165_RS04670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID165_RS04700	COG2207	Transcriptional regulator
ID165_RS04700	COG1609	Transcriptional regulator
ID165_RS04710	COG4771	TonB-dependent receptor
ID165_RS04725	COG0745	RESPONSE REGULATOR receiver
ID165_RS04755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS04760	COG0156	8-amino-7-oxononanoate synthase activity
ID165_RS04770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID165_RS04775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ID165_RS04790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ID165_RS04805	COG0442	prolyl-tRNA aminoacylation
ID165_RS04815	COG4864	UPF0365 protein
ID165_RS04825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ID165_RS04845	COG1054	Belongs to the UPF0176 family
ID165_RS04855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID165_RS04865	COG1215	transferase activity, transferring glycosyl groups
ID165_RS04905	COG0673	inositol 2-dehydrogenase activity
ID165_RS04915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID165_RS04930	COG4251	negative regulation of phosphorylation
ID165_RS04935	COG1556	Lactate utilization protein
ID165_RS04940	COG1139	Iron-sulfur cluster binding protein
ID165_RS04945	COG0247	lactate metabolic process
ID165_RS04955	COG2188	Transcriptional regulator
ID165_RS04960	COG3347	Dehydrogenase
ID165_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS04965	COG4952	isomerase
ID165_RS04970	COG3119	arylsulfatase activity
ID165_RS04975	COG3386	PFAM SMP-30 Gluconolaconase
ID165_RS05000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ID165_RS05015	COG0215	cysteine-tRNA ligase activity
ID165_RS05025	COG0138	bifunctional purine biosynthesis protein purh
ID165_RS05040	COG2205	protein histidine kinase activity
ID165_RS05040	COG0784	Response regulator, receiver
ID165_RS05090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ID165_RS05090	COG0519	Catalyzes the synthesis of GMP from XMP
ID165_RS05100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ID165_RS05110	COG1393	Belongs to the ArsC family
ID165_RS05125	COG2808	Putative FMN-binding domain
ID165_RS05130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID165_RS05170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ID165_RS05195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID165_RS05200	COG2183	response to ionizing radiation
ID165_RS05230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID165_RS05245	COG3620	sequence-specific DNA binding
ID165_RS05285	COG2514	catechol 2,3-dioxygenase activity
ID165_RS05290	COG3661	Belongs to the glycosyl hydrolase 67 family
ID165_RS05305	COG0525	valine-tRNA ligase activity
ID165_RS05310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID165_RS05315	COG2267	carboxylic ester hydrolase activity
ID165_RS05335	COG2169	Transcriptional regulator
ID165_RS05400	COG4452	Inner membrane protein CreD
ID165_RS05420	COG3279	Response regulator of the LytR AlgR family
ID165_RS05425	COG3275	phosphorelay sensor kinase activity
ID165_RS05455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID165_RS05465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID165_RS05470	COG2957	Belongs to the agmatine deiminase family
ID165_RS05480	COG1011	Hydrolase
ID165_RS05490	COG3279	Response regulator of the LytR AlgR family
ID165_RS05555	COG1525	nuclease
ID165_RS05575	COG1309	transcriptional regulator
ID165_RS05605	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS05625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ID165_RS05640	COG1201	RNA secondary structure unwinding
ID165_RS05710	COG3279	Response regulator of the LytR AlgR family
ID165_RS05720	COG0668	transmembrane transport
ID165_RS05740	COG0702	epimerase
ID165_RS05760	COG0438	transferase activity, transferring glycosyl groups
ID165_RS05765	COG0110	maltose O-acetyltransferase activity
ID165_RS05780	COG0438	transferase activity, transferring glycosyl groups
ID165_RS05785	COG1215	transferase activity, transferring glycosyl groups
ID165_RS05805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID165_RS05810	COG0745	RESPONSE REGULATOR receiver
ID165_RS05820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID165_RS05840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ID165_RS05845	COG0489	protein tyrosine kinase activity
ID165_RS05850	COG0358	DNA primase activity
ID165_RS05855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID165_RS05855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID165_RS05865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ID165_RS05870	COG2205	protein histidine kinase activity
ID165_RS05890	COG1609	Transcriptional regulator
ID165_RS05895	COG0191	fructose-bisphosphate aldolase activity
ID165_RS05905	COG0205	6-phosphofructokinase activity
ID165_RS05910	COG1803	Methylglyoxal synthase
ID165_RS05915	COG1770	oligopeptidase
ID165_RS05920	COG1970	mechanosensitive ion channel activity
ID165_RS05980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID165_RS05990	COG0730	response to heat
ID165_RS06010	COG1522	sequence-specific DNA binding
ID165_RS06020	COG0534	Mate efflux family protein
ID165_RS06040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID165_RS06045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID165_RS06050	COG2096	Adenosyltransferase
ID165_RS06055	COG1136	(ABC) transporter
ID165_RS06065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID165_RS06085	COG1388	LysM domain
ID165_RS06085	COG0791	NLP P60 protein
ID165_RS06100	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ID165_RS06110	COG0494	nUDIX hydrolase
ID165_RS06125	COG0393	Putative heavy-metal-binding
ID165_RS06130	COG0745	RESPONSE REGULATOR receiver
ID165_RS06145	COG0646	methionine synthase
ID165_RS06145	COG1410	methionine synthase
ID165_RS06150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ID165_RS06160	COG0702	epimerase
ID165_RS06165	COG4771	TonB-dependent receptor
ID165_RS06175	COG1595	DNA-templated transcription, initiation
ID165_RS06190	COG0671	phosphoesterase, PA-phosphatase related
ID165_RS06195	COG0408	coproporphyrinogen oxidase activity
ID165_RS06205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID165_RS06225	COG2204	response regulator
ID165_RS06265	COG0438	transferase activity, transferring glycosyl groups
ID165_RS06275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ID165_RS06285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ID165_RS06295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS06300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ID165_RS06355	COG0489	protein tyrosine kinase activity
ID165_RS06370	COG0438	transferase activity, transferring glycosyl groups
ID165_RS06445	COG2824	Alkylphosphonate utilization operon protein PhnA
ID165_RS06460	COG0673	inositol 2-dehydrogenase activity
ID165_RS06470	COG0702	epimerase
ID165_RS06475	COG0656	L-ascorbic acid biosynthetic process
ID165_RS06500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID165_RS06515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID165_RS06545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ID165_RS06585	COG0811	peptide transport
ID165_RS06590	COG0848	biopolymer transport protein
ID165_RS06605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ID165_RS06610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ID165_RS06625	COG1288	antiporter activity
ID165_RS06630	COG0667	Aldo Keto reductase
ID165_RS06650	COG1914	H( )-stimulated, divalent metal cation uptake system
ID165_RS06685	COG1199	ATP-dependent helicase activity
ID165_RS06685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ID165_RS06690	COG2321	neutral zinc metallopeptidase
ID165_RS06710	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID165_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS06730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID165_RS06745	COG0702	epimerase
ID165_RS06750	COG1629	transport
ID165_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS06835	COG3483	tryptophan 2,3-dioxygenase activity
ID165_RS06840	COG0534	Mate efflux family protein
ID165_RS06845	COG0363	glucosamine-6-phosphate deaminase activity
ID165_RS06850	COG0534	Mate efflux family protein
ID165_RS06870	COG4771	TonB-dependent receptor
ID165_RS06890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID165_RS06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID165_RS06900	COG4807	Protein conserved in bacteria
ID165_RS06905	COG4895	conserved protein (DUF2196)
ID165_RS06930	COG3592	Divergent 4Fe-4S mono-cluster
ID165_RS06945	COG1621	beta-fructofuranosidase activity
ID165_RS06950	COG1819	glycosyl
ID165_RS06965	COG2814	Major facilitator Superfamily
ID165_RS06975	COG1607	acyl-coa hydrolase
ID165_RS06980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ID165_RS06985	COG0307	riboflavin synthase, alpha
ID165_RS06995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID165_RS07010	COG0577	efflux transmembrane transporter activity
ID165_RS07010	COG1136	(ABC) transporter
ID165_RS07020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS07045	COG4654	Cytochrome c, class I
ID165_RS07050	COG0673	inositol 2-dehydrogenase activity
ID165_RS07065	COG0662	Cupin 2, conserved barrel domain protein
ID165_RS07065	COG2207	Transcriptional regulator
ID165_RS07070	COG3279	Response regulator of the LytR AlgR family
ID165_RS07075	COG3275	phosphorelay sensor kinase activity
ID165_RS07085	COG0450	alkyl hydroperoxide reductase
ID165_RS07095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ID165_RS07100	COG1335	isochorismatase
ID165_RS07120	COG1960	acyl-CoA dehydrogenase activity
ID165_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
ID165_RS07155	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ID165_RS07160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS07165	COG0110	maltose O-acetyltransferase activity
ID165_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS07180	COG1904	glucuronate isomerase
ID165_RS07185	COG1609	Transcriptional regulator
ID165_RS07195	COG4771	TonB-dependent receptor
ID165_RS07205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ID165_RS07205	COG0116	Belongs to the methyltransferase superfamily
ID165_RS07215	COG1984	allophanate hydrolase subunit 2
ID165_RS07220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ID165_RS07225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ID165_RS07235	COG3852	Histidine kinase
ID165_RS07240	COG0784	Response regulator, receiver
ID165_RS07245	COG4251	negative regulation of phosphorylation
ID165_RS07260	COG2204	response regulator
ID165_RS07265	COG2204	response regulator
ID165_RS07350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS07415	COG0702	epimerase
ID165_RS07420	COG4771	TonB-dependent receptor
ID165_RS07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS07550	COG1428	Deoxynucleoside kinase
ID165_RS07555	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID165_RS07575	COG1940	carbohydrate kinase activity
ID165_RS07610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ID165_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID165_RS07635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID165_RS07670	COG3541	Predicted nucleotidyltransferase
ID165_RS07680	COG0471	metal ion transport
ID165_RS07685	COG1136	(ABC) transporter
ID165_RS07690	COG0045	succinate-CoA ligase (ADP-forming) activity
ID165_RS07700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ID165_RS07710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ID165_RS07715	COG1959	2 iron, 2 sulfur cluster binding
ID165_RS07720	COG0730	response to heat
ID165_RS07730	COG0783	Belongs to the Dps family
ID165_RS07745	COG0137	argininosuccinate synthase activity
ID165_RS07750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ID165_RS07755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID165_RS07765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ID165_RS07775	COG0165	Argininosuccinate lyase
ID165_RS07785	COG0288	reversible hydration of carbon dioxide
ID165_RS07795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ID165_RS07805	COG2177	Part of the ABC transporter FtsEX involved in
ID165_RS07815	COG1968	undecaprenyl-diphosphatase activity
ID165_RS07820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ID165_RS07825	COG0196	riboflavin kinase activity
ID165_RS07835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ID165_RS07845	COG4771	TonB-dependent receptor
ID165_RS07855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID165_RS07875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID165_RS07910	COG0450	alkyl hydroperoxide reductase
ID165_RS07930	COG1132	(ABC) transporter
ID165_RS07935	COG1309	transcriptional regulator
ID165_RS07960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ID165_RS08025	COG0513	Belongs to the DEAD box helicase family
ID165_RS08040	COG1473	amidohydrolase
ID165_RS08100	COG0745	RESPONSE REGULATOR receiver
ID165_RS08110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID165_RS08120	COG0791	NLP P60 protein
ID165_RS08160	COG1196	nuclear chromosome segregation
ID165_RS08195	COG0577	efflux transmembrane transporter activity
ID165_RS08195	COG1136	(ABC) transporter
ID165_RS08210	COG0667	Aldo Keto reductase
ID165_RS08265	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ID165_RS08280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID165_RS08285	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ID165_RS08290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID165_RS08300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ID165_RS08335	COG1929	Belongs to the glycerate kinase type-1 family
ID165_RS08340	COG1115	amino acid carrier protein
ID165_RS08370	COG0123	including yeast histone deacetylase and acetoin utilization protein
ID165_RS08380	COG1950	PFAM Membrane protein of
ID165_RS08400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ID165_RS08405	COG1309	transcriptional regulator
ID165_RS08415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ID165_RS08420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ID165_RS08445	COG3275	phosphorelay sensor kinase activity
ID165_RS08455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ID165_RS08475	COG1104	cysteine desulfurase activity
ID165_RS08505	COG0673	inositol 2-dehydrogenase activity
ID165_RS08525	COG3507	Belongs to the glycosyl hydrolase 43 family
ID165_RS08550	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID165_RS08555	COG1121	(ABC) transporter
ID165_RS08560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID165_RS08560	COG1321	iron dependent repressor
ID165_RS08565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID165_RS08575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ID165_RS08590	COG2226	methyltransferase
ID165_RS08625	COG1733	regulation of RNA biosynthetic process
ID165_RS08630	COG0697	spore germination
ID165_RS08650	COG1733	regulation of RNA biosynthetic process
ID165_RS08655	COG0783	Belongs to the Dps family
ID165_RS08660	COG2267	carboxylic ester hydrolase activity
ID165_RS08685	COG3275	phosphorelay sensor kinase activity
ID165_RS08690	COG3279	Response regulator of the LytR AlgR family
ID165_RS08695	COG1764	response to oxidative stress
ID165_RS08725	COG0702	epimerase
ID165_RS08730	COG4771	TonB-dependent receptor
ID165_RS08780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID165_RS08785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID165_RS08795	COG4221	oxidoreductase activity
ID165_RS08800	COG3292	Two component regulator propeller
ID165_RS08800	COG0745	RESPONSE REGULATOR receiver
ID165_RS08800	COG2205	protein histidine kinase activity
ID165_RS08805	COG1764	response to oxidative stress
ID165_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS08825	COG3608	succinylglutamate desuccinylase aspartoacylase
ID165_RS08850	COG1643	Atp-dependent helicase
ID165_RS08875	COG2197	response regulator
ID165_RS08885	COG4771	TonB-dependent receptor
ID165_RS08890	COG1321	iron dependent repressor
ID165_RS08920	COG0667	Aldo Keto reductase
ID165_RS08930	COG1082	Xylose isomerase domain protein TIM barrel
ID165_RS08935	COG3254	rhamnose metabolic process
ID165_RS08960	COG0436	Aminotransferase
ID165_RS08965	COG0010	Belongs to the arginase family
ID165_RS08975	COG0018	arginyl-trna synthetase
ID165_RS08980	COG0386	Belongs to the glutathione peroxidase family
ID165_RS08985	COG1575	Belongs to the MenA family. Type 1 subfamily
ID165_RS09030	COG2308	Evidence 4 Homologs of previously reported genes of
ID165_RS09030	COG2307	Protein conserved in bacteria
ID165_RS09055	COG0482	sulfurtransferase activity
ID165_RS09060	COG0564	pseudouridine synthase activity
ID165_RS09065	COG1404	Belongs to the peptidase S8 family
ID165_RS09070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ID165_RS09080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ID165_RS09085	COG2086	electron transfer activity
ID165_RS09100	COG0604	alcohol dehydrogenase
ID165_RS09105	COG0305	Participates in initiation and elongation during chromosome replication
ID165_RS09110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ID165_RS09115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ID165_RS09140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID165_RS09165	COG2234	aminopeptidase activity
ID165_RS09170	COG1528	Iron-storage protein
ID165_RS09200	COG2080	2 iron, 2 sulfur cluster binding
ID165_RS09215	COG3279	Response regulator of the LytR AlgR family
ID165_RS09220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ID165_RS09225	COG4221	oxidoreductase activity
ID165_RS09250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID165_RS09255	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS09255	COG4977	sequence-specific DNA binding
ID165_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS09285	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS09285	COG4977	sequence-specific DNA binding
ID165_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS09300	COG4221	oxidoreductase activity
ID165_RS09310	COG4977	sequence-specific DNA binding
ID165_RS09310	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS09350	COG4221	oxidoreductase activity
ID165_RS09370	COG1678	Uncharacterized ACR, COG1678
ID165_RS09375	COG0259	pyridoxamine-phosphate oxidase activity
ID165_RS09385	COG0739	heme binding
ID165_RS09390	COG0492	ferredoxin-NADP+ reductase activity
ID165_RS09395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ID165_RS09400	COG1185	polyribonucleotide nucleotidyltransferase activity
ID165_RS09405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ID165_RS09435	COG0702	epimerase
ID165_RS09440	COG1629	transport
ID165_RS09450	COG1191	sigma factor activity
ID165_RS09455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ID165_RS09460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ID165_RS09465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ID165_RS09470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID165_RS09480	COG1629	transport
ID165_RS09480	COG4206	TonB-dependent receptor
ID165_RS09485	COG0579	oxidoreductase
ID165_RS09490	COG0069	glutamate synthase activity
ID165_RS09495	COG0429	hydrolase of the alpha beta-hydrolase fold
ID165_RS09505	COG2081	HI0933 family
ID165_RS09510	COG0433	COG0433 Predicted ATPase
ID165_RS09530	COG0702	epimerase
ID165_RS09535	COG1629	transport
ID165_RS09560	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS09565	COG1733	regulation of RNA biosynthetic process
ID165_RS09580	COG0667	Aldo Keto reductase
ID165_RS09605	COG1131	(ABC) transporter
ID165_RS09610	COG2755	lipolytic protein G-D-S-L family
ID165_RS09620	COG2169	Transcriptional regulator
ID165_RS09620	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS09650	COG4952	isomerase
ID165_RS09685	COG2329	Antibiotic biosynthesis monooxygenase
ID165_RS09710	COG3291	Pkd domain containing protein
ID165_RS09725	COG0561	phosphatase activity
ID165_RS09730	COG4771	TonB-dependent receptor
ID165_RS09735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ID165_RS09740	COG0745	RESPONSE REGULATOR receiver
ID165_RS09740	COG2205	protein histidine kinase activity
ID165_RS09740	COG3292	Two component regulator propeller
ID165_RS09745	COG2115	Belongs to the xylose isomerase family
ID165_RS09760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID165_RS09765	COG1760	l-serine dehydratase
ID165_RS09780	COG0424	maF-like protein
ID165_RS09790	COG0439	Biotin carboxylase
ID165_RS09840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID165_RS09845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID165_RS09850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ID165_RS09860	COG0494	nUDIX hydrolase
ID165_RS09885	COG2382	esterase
ID165_RS09900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ID165_RS09905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ID165_RS09910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ID165_RS09915	COG0131	Imidazoleglycerol-phosphate dehydratase
ID165_RS09915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ID165_RS09925	COG0463	Glycosyl transferase, family 2
ID165_RS09935	COG3876	Protein conserved in bacteria
ID165_RS09940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ID165_RS09950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID165_RS09955	COG0300	oxidoreductase activity
ID165_RS09960	COG1058	Belongs to the CinA family
ID165_RS09960	COG1546	Belongs to the CinA family
ID165_RS09965	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID165_RS09990	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ID165_RS09990	COG1703	isobutyryl-CoA mutase activity
ID165_RS09990	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ID165_RS09995	COG0427	acetyl-CoA hydrolase
ID165_RS10000	COG2814	Major facilitator Superfamily
ID165_RS10005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID165_RS10015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID165_RS10020	COG2323	membrane
ID165_RS10030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID165_RS10035	COG2239	Acts as a magnesium transporter
ID165_RS10040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ID165_RS10045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ID165_RS10055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ID165_RS10060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID165_RS10065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ID165_RS10070	COG0511	ligase activity, forming carbon-carbon bonds
ID165_RS10075	COG0439	Biotin carboxylase
ID165_RS10105	COG2326	polyphosphate kinase activity
ID165_RS10145	COG0471	metal ion transport
ID165_RS10145	COG3273	potassium ion transport
ID165_RS10155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ID165_RS10160	COG0187	DNA topoisomerase II activity
ID165_RS10180	COG0116	Belongs to the methyltransferase superfamily
ID165_RS10180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ID165_RS10185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID165_RS10190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID165_RS10195	COG0659	secondary active sulfate transmembrane transporter activity
ID165_RS10205	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID165_RS10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID165_RS10215	COG0825	malonyl-CoA metabolic process
ID165_RS10235	COG1620	l-lactate permease
ID165_RS10245	COG0488	(ABC) transporter
ID165_RS10255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ID165_RS10275	COG4206	TonB-dependent receptor
ID165_RS10275	COG1629	transport
ID165_RS10390	COG1629	transport
ID165_RS10555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ID165_RS10605	COG0270	DNA (cytosine-5-)-methyltransferase activity
ID165_RS10630	COG1595	DNA-templated transcription, initiation
ID165_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS10660	COG1733	regulation of RNA biosynthetic process
ID165_RS10730	COG2267	carboxylic ester hydrolase activity
ID165_RS10775	COG0733	neurotransmitter:sodium symporter activity
ID165_RS10885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ID165_RS10895	COG3781	membrane
ID165_RS10905	COG0702	epimerase
ID165_RS10930	COG1201	RNA secondary structure unwinding
ID165_RS10935	COG1793	dna ligase
ID165_RS10940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ID165_RS10940	COG1793	dna ligase
ID165_RS10950	COG1283	sodium-dependent phosphate transmembrane transporter activity
ID165_RS10990	COG3361	conserved protein (COG2071)
ID165_RS10995	COG1506	peptidase
ID165_RS10995	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS11000	COG1522	sequence-specific DNA binding
ID165_RS11005	COG0719	Fe-S assembly protein
ID165_RS11015	COG0396	ATPase activity
ID165_RS11020	COG0719	Fe-S assembly protein
ID165_RS11025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ID165_RS11030	COG2166	iron-sulfur cluster assembly
ID165_RS11035	COG2151	metal-sulfur cluster biosynthetic enzyme
ID165_RS11055	COG0022	dehydrogenase e1 component
ID165_RS11060	COG0686	Belongs to the AlaDH PNT family
ID165_RS11065	COG3279	Response regulator of the LytR AlgR family
ID165_RS11070	COG3275	phosphorelay sensor kinase activity
ID165_RS11140	COG1914	H( )-stimulated, divalent metal cation uptake system
ID165_RS11145	COG2133	pyrroloquinoline quinone binding
ID165_RS11155	COG0702	epimerase
ID165_RS11160	COG4771	TonB-dependent receptor
ID165_RS11170	COG1595	DNA-templated transcription, initiation
ID165_RS11175	COG3239	Fatty acid desaturase
ID165_RS11195	COG2207	Transcriptional regulator
ID165_RS11200	COG3206	protein involved in exopolysaccharide biosynthesis
ID165_RS11200	COG0489	protein tyrosine kinase activity
ID165_RS11210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ID165_RS11215	COG0489	protein tyrosine kinase activity
ID165_RS11230	COG2363	Small membrane protein
ID165_RS11235	COG2027	D-alanyl-D-alanine carboxypeptidase
ID165_RS11240	COG2267	carboxylic ester hydrolase activity
ID165_RS11255	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID165_RS11270	COG0179	Fumarylacetoacetate (FAA) hydrolase
ID165_RS11275	COG0739	heme binding
ID165_RS11280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ID165_RS11285	COG3959	Transketolase, thiamine diphosphate binding domain
ID165_RS11290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ID165_RS11305	COG4946	Tricorn protease homolog
ID165_RS11305	COG0793	Belongs to the peptidase S41A family
ID165_RS11340	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ID165_RS11355	COG4206	TonB-dependent receptor
ID165_RS11360	COG2304	oxidoreductase activity
ID165_RS11375	COG0183	Belongs to the thiolase family
ID165_RS11400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ID165_RS11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ID165_RS11420	COG0513	Belongs to the DEAD box helicase family
ID165_RS11425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ID165_RS11435	COG0758	DNA mediated transformation
ID165_RS11455	COG0673	inositol 2-dehydrogenase activity
ID165_RS11480	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ID165_RS11485	COG4771	TonB-dependent receptor
ID165_RS11500	COG1506	peptidase
ID165_RS11500	COG4946	Tricorn protease homolog
ID165_RS11500	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS11505	COG0346	lactoylglutathione lyase activity
ID165_RS11515	COG1629	transport
ID165_RS11550	COG1331	Highly conserved protein containing a thioredoxin domain
ID165_RS11555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ID165_RS11560	COG2207	Transcriptional regulator
ID165_RS11570	COG2226	methyltransferase
ID165_RS11575	COG1136	(ABC) transporter
ID165_RS11575	COG0577	efflux transmembrane transporter activity
ID165_RS11585	COG3876	Protein conserved in bacteria
ID165_RS11590	COG0577	efflux transmembrane transporter activity
ID165_RS11590	COG1136	(ABC) transporter
ID165_RS11600	COG0577	efflux transmembrane transporter activity
ID165_RS11600	COG1136	(ABC) transporter
ID165_RS11610	COG0577	efflux transmembrane transporter activity
ID165_RS11610	COG1136	(ABC) transporter
ID165_RS11615	COG0577	efflux transmembrane transporter activity
ID165_RS11620	COG0577	efflux transmembrane transporter activity
ID165_RS11620	COG1136	(ABC) transporter
ID165_RS11635	COG2204	response regulator
ID165_RS11640	COG3852	Histidine kinase
ID165_RS11645	COG4771	TonB-dependent receptor
ID165_RS11670	COG0714	Associated with various cellular activities
ID165_RS11700	COG4941	Belongs to the sigma-70 factor family
ID165_RS11720	COG0626	cystathionine gamma-synthase activity
ID165_RS11745	COG2226	methyltransferase
ID165_RS11790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ID165_RS11835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ID165_RS11840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ID165_RS11935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ID165_RS11965	COG4771	TonB-dependent receptor
ID165_RS11970	COG0586	Pfam SNARE associated Golgi protein
ID165_RS11990	COG0628	permease
ID165_RS12015	COG1881	PFAM PEBP family protein
ID165_RS12035	COG5002	protein histidine kinase activity
ID165_RS12040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ID165_RS12040	COG0574	Belongs to the PEP-utilizing enzyme family
ID165_RS12045	COG0071	Belongs to the small heat shock protein (HSP20) family
ID165_RS12055	COG0745	RESPONSE REGULATOR receiver
ID165_RS12060	COG5002	protein histidine kinase activity
ID165_RS12065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ID165_RS12105	COG1132	(ABC) transporter
ID165_RS12115	COG0438	transferase activity, transferring glycosyl groups
ID165_RS12145	COG0463	Glycosyl transferase, family 2
ID165_RS12145	COG1216	Glycosyl transferase, family 2
ID165_RS12175	COG1073	alpha beta
ID165_RS12175	COG2226	methyltransferase
ID165_RS12190	COG2207	Transcriptional regulator
ID165_RS12190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID165_RS12195	COG1902	pentaerythritol trinitrate reductase activity
ID165_RS12220	COG1476	TRANSCRIPTIONal
ID165_RS12230	COG0004	ammonium transporteR
ID165_RS12235	COG0702	epimerase
ID165_RS12240	COG4771	TonB-dependent receptor
ID165_RS12250	COG1595	DNA-templated transcription, initiation
ID165_RS12255	COG2814	Major facilitator Superfamily
ID165_RS12255	COG0477	Major facilitator Superfamily
ID165_RS12260	COG3119	arylsulfatase activity
ID165_RS12265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID165_RS12270	COG0702	epimerase
ID165_RS12275	COG4771	TonB-dependent receptor
ID165_RS12300	COG4771	TonB-dependent receptor
ID165_RS12310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ID165_RS12315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ID165_RS12340	COG0673	inositol 2-dehydrogenase activity
ID165_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS12355	COG0640	Transcriptional regulator
ID165_RS12360	COG5658	integral membrane protein
ID165_RS12385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID165_RS12390	COG3264	Mechanosensitive ion channel
ID165_RS12390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ID165_RS12395	COG1278	Cold shock
ID165_RS12400	COG0588	phosphoglycerate mutase activity
ID165_RS12410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ID165_RS12415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ID165_RS12420	COG1136	(ABC) transporter
ID165_RS12420	COG0577	efflux transmembrane transporter activity
ID165_RS12445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ID165_RS12460	COG1573	uracil-dna glycosylase
ID165_RS12485	COG0577	efflux transmembrane transporter activity
ID165_RS12485	COG1136	(ABC) transporter
ID165_RS12490	COG0673	inositol 2-dehydrogenase activity
ID165_RS12510	COG0577	efflux transmembrane transporter activity
ID165_RS12540	COG0653	protein targeting
ID165_RS12565	COG2207	Transcriptional regulator
ID165_RS12575	COG0629	single-stranded DNA binding
ID165_RS12590	COG0629	single-stranded DNA binding
ID165_RS12605	COG0667	Aldo Keto reductase
ID165_RS12610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ID165_RS12620	COG0582	viral genome integration into host DNA
ID165_RS12660	COG0205	6-phosphofructokinase activity
ID165_RS12670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ID165_RS12715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID165_RS12725	COG0571	ribonuclease III activity
ID165_RS12735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ID165_RS12740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ID165_RS12765	COG0339	signal peptide processing
ID165_RS12770	COG0628	permease
ID165_RS12780	COG2205	protein histidine kinase activity
ID165_RS12780	COG0784	Response regulator, receiver
ID165_RS12790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ID165_RS12795	COG2205	protein histidine kinase activity
ID165_RS12805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ID165_RS12820	COG0012	GTP binding
ID165_RS12835	COG0488	(ABC) transporter
ID165_RS12865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ID165_RS12870	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID165_RS12880	COG2135	peptidase activity
ID165_RS12885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID165_RS12910	COG1940	carbohydrate kinase activity
ID165_RS12925	COG3119	arylsulfatase activity
ID165_RS12930	COG1053	succinate dehydrogenase
ID165_RS12940	COG3537	Alpha-1,2-mannosidase
ID165_RS12950	COG4771	TonB-dependent receptor
ID165_RS12960	COG1629	transport
ID165_RS12970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID165_RS12985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ID165_RS12995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ID165_RS13005	COG0189	ligase activity
ID165_RS13020	COG0739	heme binding
ID165_RS13050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ID165_RS13065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID165_RS13075	COG1166	arginine decarboxylase activity
ID165_RS13085	COG0702	epimerase
ID165_RS13090	COG4771	TonB-dependent receptor
ID165_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS13105	COG1970	mechanosensitive ion channel activity
ID165_RS13110	COG0577	efflux transmembrane transporter activity
ID165_RS13125	COG1663	tetraacyldisaccharide 4'-kinase activity
ID165_RS13130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ID165_RS13145	COG0406	alpha-ribazole phosphatase activity
ID165_RS13160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ID165_RS13170	COG0583	DNA-binding transcription factor activity
ID165_RS13175	COG2986	histidine ammonia-lyase
ID165_RS13180	COG1228	amidohydrolase
ID165_RS13185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ID165_RS13205	COG0277	FAD linked oxidase domain protein
ID165_RS13205	COG0247	lactate metabolic process
ID165_RS13210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ID165_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS13245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID165_RS13255	COG0006	proline dipeptidase activity
ID165_RS13260	COG0612	Peptidase, M16
ID165_RS13270	COG1388	LysM domain
ID165_RS13270	COG1705	Flagellar rod assembly protein muramidase FlgJ
ID165_RS13285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ID165_RS13320	COG2132	Multicopper oxidase
ID165_RS13340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS13440	COG4206	TonB-dependent receptor
ID165_RS13440	COG1629	transport
ID165_RS13480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ID165_RS13550	COG2003	Belongs to the UPF0758 family
ID165_RS13645	COG0745	RESPONSE REGULATOR receiver
ID165_RS13650	COG2205	protein histidine kinase activity
ID165_RS13670	COG0463	Glycosyl transferase, family 2
ID165_RS13675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID165_RS13685	COG4221	oxidoreductase activity
ID165_RS13780	COG1131	(ABC) transporter
ID165_RS13785	COG3275	phosphorelay sensor kinase activity
ID165_RS13790	COG3279	Response regulator of the LytR AlgR family
ID165_RS13795	COG4977	sequence-specific DNA binding
ID165_RS13795	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS13800	COG0300	oxidoreductase activity
ID165_RS13815	COG4977	sequence-specific DNA binding
ID165_RS13815	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS13820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID165_RS13825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID165_RS13830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID165_RS13845	COG0297	glycogen (starch) synthase activity
ID165_RS13855	COG0110	maltose O-acetyltransferase activity
ID165_RS13885	COG0438	transferase activity, transferring glycosyl groups
ID165_RS13890	COG1215	transferase activity, transferring glycosyl groups
ID165_RS13895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ID165_RS13905	COG1045	serine acetyltransferase
ID165_RS13910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID165_RS13920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ID165_RS13925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS13935	COG0662	Cupin 2, conserved barrel domain protein
ID165_RS13935	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ID165_RS13950	COG3206	protein involved in exopolysaccharide biosynthesis
ID165_RS13950	COG0489	protein tyrosine kinase activity
ID165_RS13970	COG3693	PFAM glycoside hydrolase, family 10
ID165_RS13970	COG2382	esterase
ID165_RS13985	COG0702	epimerase
ID165_RS14000	COG1629	transport
ID165_RS14020	COG0657	acetylesterase activity
ID165_RS14020	COG2755	lipolytic protein G-D-S-L family
ID165_RS14035	COG2851	Citrate transporter
ID165_RS14040	COG3693	PFAM glycoside hydrolase, family 10
ID165_RS14040	COG3507	Belongs to the glycosyl hydrolase 43 family
ID165_RS14040	COG2382	esterase
ID165_RS14045	COG2382	esterase
ID165_RS14065	COG1063	alcohol dehydrogenase
ID165_RS14075	COG1609	Transcriptional regulator
ID165_RS14085	COG1320	monovalent cation:proton antiporter activity
ID165_RS14090	COG2212	antiporter activity
ID165_RS14095	COG1863	multisubunit Na H antiporter MnhE subunit
ID165_RS14100	COG0651	ATP synthesis coupled electron transport
ID165_RS14105	COG1006	Multisubunit Na H antiporter MnhC subunit
ID165_RS14110	COG2111	Na H antiporter
ID165_RS14120	COG2111	Na H antiporter
ID165_RS14120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ID165_RS14140	COG0702	epimerase
ID165_RS14145	COG4771	TonB-dependent receptor
ID165_RS14155	COG4771	TonB-dependent receptor
ID165_RS14160	COG2205	protein histidine kinase activity
ID165_RS14160	COG0745	RESPONSE REGULATOR receiver
ID165_RS14160	COG3292	Two component regulator propeller
ID165_RS14165	COG3292	Two component regulator propeller
ID165_RS14165	COG0745	RESPONSE REGULATOR receiver
ID165_RS14165	COG2205	protein histidine kinase activity
ID165_RS14175	COG0745	RESPONSE REGULATOR receiver
ID165_RS14185	COG2353	YceI-like domain
ID165_RS14225	COG4974	Belongs to the 'phage' integrase family
ID165_RS14355	COG4771	TonB-dependent receptor
ID165_RS14375	COG3328	transposase activity
ID165_RS14465	COG4974	Belongs to the 'phage' integrase family
ID165_RS14470	COG2003	Belongs to the UPF0758 family
ID165_RS14505	COG2003	Belongs to the UPF0758 family
ID165_RS14525	COG0587	DNA-directed DNA polymerase activity
ID165_RS14535	COG3620	sequence-specific DNA binding
ID165_RS14555	COG2003	Belongs to the UPF0758 family
ID165_RS14565	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ID165_RS14570	COG0352	thiamine-phosphate diphosphorylase activity
ID165_RS14575	COG0351	phosphomethylpyrimidine kinase
ID165_RS14620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ID165_RS14640	COG0702	epimerase
ID165_RS14645	COG4771	TonB-dependent receptor
ID165_RS14650	COG2271	Major facilitator Superfamily
ID165_RS14655	COG2188	Transcriptional regulator
ID165_RS14675	COG0436	Aminotransferase
ID165_RS14700	COG1914	H( )-stimulated, divalent metal cation uptake system
ID165_RS14705	COG2133	pyrroloquinoline quinone binding
ID165_RS14715	COG0702	epimerase
ID165_RS14720	COG4771	TonB-dependent receptor
ID165_RS14730	COG1595	DNA-templated transcription, initiation
ID165_RS14755	COG0420	3'-5' exonuclease activity
ID165_RS14770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID165_RS14810	COG3842	ATPase activity
ID165_RS14835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID165_RS14850	COG5002	protein histidine kinase activity
ID165_RS14855	COG0745	RESPONSE REGULATOR receiver
ID165_RS14865	COG4974	Belongs to the 'phage' integrase family
ID165_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS14945	COG2207	Transcriptional regulator
ID165_RS14960	COG4221	oxidoreductase activity
ID165_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS14990	COG1064	alcohol dehydrogenase
ID165_RS14995	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS14995	COG4977	sequence-specific DNA binding
ID165_RS15005	COG0800	Aldolase
ID165_RS15035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID165_RS15040	COG2076	Multidrug Resistance protein
ID165_RS15070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ID165_RS15075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ID165_RS15085	COG0415	Belongs to the DNA photolyase family
ID165_RS15090	COG1193	negative regulation of DNA recombination
ID165_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS15115	COG2258	MOSC domain
ID165_RS15130	COG2610	gluconate transmembrane transporter activity
ID165_RS15145	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ID165_RS15150	COG1704	LemA family
ID165_RS15160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID165_RS15165	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS15185	COG0513	Belongs to the DEAD box helicase family
ID165_RS15190	COG2814	Major facilitator Superfamily
ID165_RS15200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ID165_RS15220	COG0745	RESPONSE REGULATOR receiver
ID165_RS15225	COG5002	protein histidine kinase activity
ID165_RS15245	COG0385	Bile acid
ID165_RS15250	COG4948	Mandelate Racemase Muconate Lactonizing
ID165_RS15260	COG4948	Mandelate Racemase Muconate Lactonizing
ID165_RS15275	COG1629	transport
ID165_RS15275	COG4206	TonB-dependent receptor
ID165_RS15290	COG5505	Protein of unknown function (DUF819)
ID165_RS15305	COG0473	3-isopropylmalate dehydrogenase activity
ID165_RS15310	COG1024	Enoyl-CoA hydratase
ID165_RS15335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ID165_RS15340	COG0154	amidase activity
ID165_RS15345	COG1388	LysM domain
ID165_RS15345	COG0741	lytic transglycosylase activity
ID165_RS15355	COG0281	malic enzyme
ID165_RS15355	COG0280	phosphate acetyltransferase
ID165_RS15360	COG0632	four-way junction helicase activity
ID165_RS15370	COG0509	glycine decarboxylation via glycine cleavage system
ID165_RS15390	COG1561	YicC-like family, N-terminal region
ID165_RS15400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ID165_RS15405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID165_RS15410	COG1183	phosphatidylcholine synthase activity
ID165_RS15430	COG1216	Glycosyl transferase, family 2
ID165_RS15455	COG1757	Na H antiporter
ID165_RS15480	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS15490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ID165_RS15500	COG0799	negative regulation of ribosome biogenesis
ID165_RS15505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ID165_RS15510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ID165_RS15520	COG1047	Peptidyl-prolyl cis-trans
ID165_RS15530	COG0784	Response regulator, receiver
ID165_RS15530	COG2205	protein histidine kinase activity
ID165_RS15550	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ID165_RS15560	COG2378	regulation of single-species biofilm formation
ID165_RS15580	COG0346	lactoylglutathione lyase activity
ID165_RS15590	COG1595	DNA-templated transcription, initiation
ID165_RS15600	COG2104	thiamine diphosphate biosynthetic process
ID165_RS15615	COG0352	thiamine-phosphate diphosphorylase activity
ID165_RS15615	COG0351	phosphomethylpyrimidine kinase
ID165_RS15620	COG0352	thiamine-phosphate diphosphorylase activity
ID165_RS15625	COG2022	thiamine diphosphate biosynthetic process
ID165_RS15630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ID165_RS15635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID165_RS15640	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID165_RS15660	COG0745	RESPONSE REGULATOR receiver
ID165_RS15670	COG4251	negative regulation of phosphorylation
ID165_RS15675	COG0022	dehydrogenase e1 component
ID165_RS15685	COG0702	epimerase
ID165_RS15690	COG4771	TonB-dependent receptor
ID165_RS15715	COG0124	histidyl-tRNA synthetase
ID165_RS15735	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS15740	COG0022	dehydrogenase e1 component
ID165_RS15740	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID165_RS15750	COG3275	phosphorelay sensor kinase activity
ID165_RS15765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ID165_RS15790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ID165_RS15800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ID165_RS15815	COG2095	MarC family integral membrane protein
ID165_RS15820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ID165_RS15850	COG0151	Belongs to the GarS family
ID165_RS15855	COG1774	PSP1 C-terminal conserved region
ID165_RS15870	COG1082	Xylose isomerase domain protein TIM barrel
ID165_RS15895	COG3022	response to hydroperoxide
ID165_RS15950	COG2972	Histidine kinase
ID165_RS15965	COG4771	TonB-dependent receptor
ID165_RS15985	COG0300	oxidoreductase activity
ID165_RS15990	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID165_RS16005	COG3457	Alanine racemase
ID165_RS16040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ID165_RS16045	COG1053	succinate dehydrogenase
ID165_RS16060	COG3011	Protein conserved in bacteria
ID165_RS16065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ID165_RS16080	COG0616	signal peptide processing
ID165_RS16085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ID165_RS16120	COG3279	Response regulator of the LytR AlgR family
ID165_RS16125	COG0126	phosphoglycerate kinase activity
ID165_RS16150	COG0514	ATP-dependent DNA helicase (RecQ)
ID165_RS16160	COG2333	competence protein COMEC
ID165_RS16160	COG0658	competence protein
ID165_RS16170	COG2153	protein acetylation
ID165_RS16215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ID165_RS16220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ID165_RS16225	COG0193	aminoacyl-tRNA hydrolase activity
ID165_RS16245	COG3142	Participates in the control of copper homeostasis
ID165_RS16250	COG1446	asparaginase
ID165_RS16270	COG1477	protein flavinylation
ID165_RS16300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID165_RS16320	COG0420	3'-5' exonuclease activity
ID165_RS16325	COG0419	ATPase involved in DNA repair
ID165_RS16340	COG0346	lactoylglutathione lyase activity
ID165_RS16345	COG2353	YceI-like domain
ID165_RS16355	COG0596	Alpha beta hydrolase
ID165_RS16360	COG1228	amidohydrolase
ID165_RS16365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ID165_RS16370	COG0497	DNA recombination
ID165_RS16405	COG0037	tRNA processing
ID165_RS16415	COG0039	L-malate dehydrogenase activity
ID165_RS16425	COG0668	transmembrane transport
ID165_RS16455	COG0673	inositol 2-dehydrogenase activity
ID165_RS16490	COG0702	epimerase
ID165_RS16495	COG4771	TonB-dependent receptor
ID165_RS16500	COG4771	TonB-dependent receptor
ID165_RS16505	COG0702	epimerase
ID165_RS16550	COG0714	Associated with various cellular activities
ID165_RS16580	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ID165_RS16665	COG5002	protein histidine kinase activity
ID165_RS16670	COG0745	RESPONSE REGULATOR receiver
ID165_RS16690	COG4771	TonB-dependent receptor
ID165_RS16705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ID165_RS16725	COG2308	Evidence 4 Homologs of previously reported genes of
ID165_RS16730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID165_RS16735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID165_RS16735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID165_RS16750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ID165_RS16755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ID165_RS16760	COG1570	exodeoxyribonuclease VII activity
ID165_RS16845	COG2733	membrane
ID165_RS16865	COG0745	RESPONSE REGULATOR receiver
ID165_RS16865	COG3292	Two component regulator propeller
ID165_RS16865	COG2205	protein histidine kinase activity
ID165_RS16875	COG0484	heat shock protein binding
ID165_RS16885	COG3214	Protein conserved in bacteria
ID165_RS16895	COG1136	(ABC) transporter
ID165_RS16895	COG0577	efflux transmembrane transporter activity
ID165_RS16900	COG2161	toxin-antitoxin pair type II binding
ID165_RS16905	COG4115	mRNA cleavage
ID165_RS16910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ID165_RS16920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ID165_RS16925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ID165_RS16930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ID165_RS16935	COG1605	Chorismate mutase
ID165_RS16935	COG0077	Prephenate dehydratase
ID165_RS16940	COG0436	Aminotransferase
ID165_RS16945	COG0287	Prephenate dehydrogenase
ID165_RS16975	COG3511	phospholipase C
ID165_RS17030	COG2885	chlorophyll binding
ID165_RS17030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ID165_RS17040	COG2354	Protein conserved in bacteria
ID165_RS17045	COG0778	Nitroreductase
ID165_RS17065	COG4145	pantothenate transmembrane transporter activity
ID165_RS17075	COG1902	pentaerythritol trinitrate reductase activity
ID165_RS17075	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID165_RS17105	COG3292	Two component regulator propeller
ID165_RS17105	COG2205	protein histidine kinase activity
ID165_RS17105	COG0745	RESPONSE REGULATOR receiver
ID165_RS17110	COG2353	YceI-like domain
ID165_RS17145	COG2204	response regulator
ID165_RS17170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ID165_RS17180	COG0481	GTPase activity
ID165_RS17230	COG2204	response regulator
ID165_RS17235	COG0686	Belongs to the AlaDH PNT family
ID165_RS17240	COG0802	atpase or kinase
ID165_RS17250	COG1078	dGTPase activity
ID165_RS17255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ID165_RS17260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ID165_RS17260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ID165_RS17265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ID165_RS17270	COG1131	(ABC) transporter
ID165_RS17280	COG1193	negative regulation of DNA recombination
ID165_RS17300	COG2304	oxidoreductase activity
ID165_RS17305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID165_RS17320	COG0348	domain, Protein
ID165_RS17375	COG1214	PFAM Peptidase M22, glycoprotease
ID165_RS17380	COG0793	Belongs to the peptidase S41A family
ID165_RS17385	COG0594	ribonuclease P activity
ID165_RS17390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ID165_RS17405	COG0612	Peptidase, M16
ID165_RS17415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID165_RS17430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID165_RS17440	COG1136	(ABC) transporter
ID165_RS17440	COG0577	efflux transmembrane transporter activity
ID165_RS17445	COG4181	ATPase activity
ID165_RS17530	COG0733	neurotransmitter:sodium symporter activity
ID165_RS17545	COG0181	hydroxymethylbilane synthase activity
ID165_RS17550	COG0189	ligase activity
ID165_RS17570	COG0254	rRNA binding
ID165_RS17580	COG1132	(ABC) transporter
ID165_RS17590	COG0606	chelatase, subunit chli
ID165_RS17600	COG0626	cystathionine gamma-synthase activity
ID165_RS17625	COG0101	tRNA pseudouridine synthase activity
ID165_RS17630	COG1132	(ABC) transporter
ID165_RS17650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ID165_RS17655	COG3217	Mosc domain protein beta barrel domain protein
ID165_RS17655	COG0633	Ferredoxin
ID165_RS17665	COG0443	Heat shock 70 kDa protein
ID165_RS17670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ID165_RS17685	COG0004	ammonium transporteR
ID165_RS17690	COG0113	porphobilinogen synthase activity
ID165_RS17695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ID165_RS17700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID165_RS17710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ID165_RS17715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID165_RS17725	COG0552	protein localization to endoplasmic reticulum
ID165_RS17750	COG2226	methyltransferase
ID165_RS17755	COG0463	Glycosyl transferase, family 2
ID165_RS17755	COG1216	Glycosyl transferase, family 2
ID165_RS17760	COG0463	Glycosyl transferase, family 2
ID165_RS17775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID165_RS17805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ID165_RS17810	COG1366	Belongs to the anti-sigma-factor antagonist family
ID165_RS17815	COG0735	belongs to the Fur family
ID165_RS17820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ID165_RS17830	COG0544	peptidyl-prolyl cis-trans isomerase activity
ID165_RS17835	COG0740	serine-type endopeptidase activity
ID165_RS17840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ID165_RS17845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ID165_RS17855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS17890	COG4771	TonB-dependent receptor
ID165_RS17900	COG0602	queuosine metabolic process
ID165_RS17910	COG1473	amidohydrolase
ID165_RS17915	COG0495	leucyl-tRNA aminoacylation
ID165_RS17935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ID165_RS17945	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS17990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID165_RS17990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID165_RS18010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID165_RS18025	COG0513	Belongs to the DEAD box helicase family
ID165_RS18030	COG3239	Fatty acid desaturase
ID165_RS18040	COG3258	Cytochrome c
ID165_RS18050	COG0738	Major facilitator superfamily
ID165_RS18065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID165_RS18065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID165_RS18085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ID165_RS18090	COG0300	oxidoreductase activity
ID165_RS18110	COG2322	membrane
ID165_RS18115	COG1999	signal sequence binding
ID165_RS18125	COG1845	cytochrome c oxidase, subunit III
ID165_RS18130	COG1845	cytochrome c oxidase, subunit III
ID165_RS18135	COG0109	protoheme IX farnesyltransferase activity
ID165_RS18145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ID165_RS18150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ID165_RS18175	COG0437	4 iron, 4 sulfur cluster binding
ID165_RS18190	COG2080	2 iron, 2 sulfur cluster binding
ID165_RS18195	COG2010	Cytochrome c
ID165_RS18195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ID165_RS18215	COG0539	negative regulation of cytoplasmic translation
ID165_RS18215	COG2183	response to ionizing radiation
ID165_RS18225	COG3275	phosphorelay sensor kinase activity
ID165_RS18235	COG3279	Response regulator of the LytR AlgR family
ID165_RS18285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ID165_RS18290	COG0159	tryptophan synthase activity
ID165_RS18295	COG0133	tryptophan synthase activity
ID165_RS18300	COG0135	phosphoribosylanthranilate isomerase activity
ID165_RS18305	COG0134	indole-3-glycerol-phosphate synthase activity
ID165_RS18310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ID165_RS18315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ID165_RS18315	COG0512	Glutamine amidotransferase of anthranilate synthase
ID165_RS18320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ID165_RS18335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ID165_RS18345	COG2884	Cell division ATP-binding protein ftsE
ID165_RS18370	COG0671	phosphoesterase, PA-phosphatase related
ID165_RS18375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID165_RS18385	COG0517	IMP dehydrogenase activity
ID165_RS18385	COG0617	tRNA 3'-terminal CCA addition
ID165_RS18385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ID165_RS18400	COG1595	DNA-templated transcription, initiation
ID165_RS18415	COG0504	CTP synthase activity
ID165_RS18420	COG0706	membrane insertase activity
ID165_RS18455	COG0017	Asparaginyl-tRNA synthetase
ID165_RS18460	COG0477	Major facilitator Superfamily
ID165_RS18465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ID165_RS18465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ID165_RS18470	COG2270	Major facilitator Superfamily
ID165_RS18490	COG0811	peptide transport
ID165_RS18500	COG0702	epimerase
ID165_RS18505	COG1629	transport
ID165_RS18510	COG3292	Two component regulator propeller
ID165_RS18510	COG2205	protein histidine kinase activity
ID165_RS18510	COG0745	RESPONSE REGULATOR receiver
ID165_RS18530	COG0252	asparaginase activity
ID165_RS18535	COG0084	hydrolase, TatD family'
ID165_RS18540	COG1215	transferase activity, transferring glycosyl groups
ID165_RS18565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ID165_RS18630	COG4771	TonB-dependent receptor
ID165_RS18640	COG1629	transport
ID165_RS18640	COG4206	TonB-dependent receptor
ID165_RS18665	COG0484	heat shock protein binding
ID165_RS18670	COG0789	Transcriptional regulator
ID165_RS18685	COG4106	trans-aconitate 2-methyltransferase activity
ID165_RS18705	COG1045	serine acetyltransferase
ID165_RS18720	COG0148	phosphopyruvate hydratase activity
ID165_RS18725	COG0505	Belongs to the CarA family
ID165_RS18730	COG0203	ribosomal protein L17
ID165_RS18735	COG0202	RNA polymerase activity
ID165_RS18740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ID165_RS18745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ID165_RS18750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ID165_RS18760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ID165_RS18770	COG0201	protein transport
ID165_RS18775	COG0200	Binds to the 23S rRNA
ID165_RS18780	COG1841	ribosomal large subunit assembly
ID165_RS18785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ID165_RS18790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ID165_RS18795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ID165_RS18800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ID165_RS18805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID165_RS18810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ID165_RS18815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ID165_RS18820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ID165_RS18825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ID165_RS18830	COG0255	Belongs to the universal ribosomal protein uL29 family
ID165_RS18835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ID165_RS18840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ID165_RS18845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ID165_RS18850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ID165_RS18855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ID165_RS18860	COG0089	rRNA binding
ID165_RS18865	COG0088	Forms part of the polypeptide exit tunnel
ID165_RS18870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ID165_RS18875	COG0051	transcription antitermination factor activity, RNA binding
ID165_RS18880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ID165_RS18885	COG0049	tRNA binding
ID165_RS18890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ID165_RS18900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ID165_RS18905	COG0085	RNA polymerase activity
ID165_RS18910	COG0222	ribosome binding
ID165_RS18915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ID165_RS18920	COG0081	regulation of translation
ID165_RS18925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ID165_RS18975	COG0528	UMP kinase activity
ID165_RS18980	COG0233	cytoplasmic translational termination
ID165_RS18990	COG1629	transport
ID165_RS18995	COG0702	epimerase
ID165_RS19025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ID165_RS19035	COG3387	PFAM Glycoside hydrolase 15-related
ID165_RS19040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ID165_RS19045	COG0194	GDP metabolic process
ID165_RS19055	COG1595	DNA-templated transcription, initiation
ID165_RS19075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID165_RS19080	COG0129	dihydroxy-acid dehydratase activity
ID165_RS19085	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS19110	COG0346	lactoylglutathione lyase activity
ID165_RS19115	COG4628	conserved protein (DUF2132)
ID165_RS19135	COG4555	ABC transporter
ID165_RS19145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID165_RS19165	COG1733	regulation of RNA biosynthetic process
ID165_RS19170	COG2267	carboxylic ester hydrolase activity
ID165_RS19195	COG0228	four-way junction DNA binding
ID165_RS19200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ID165_RS19205	COG0336	Belongs to the RNA methyltransferase TrmD family
ID165_RS19210	COG0335	large ribosomal subunit rRNA binding
ID165_RS19225	COG1047	Peptidyl-prolyl cis-trans
ID165_RS19235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ID165_RS19240	COG0105	UTP biosynthetic process
ID165_RS19245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID165_RS19270	COG2223	nitrite transmembrane transporter activity
ID165_RS19275	COG0243	molybdopterin cofactor binding
ID165_RS19280	COG1773	rubredoxin
ID165_RS19300	COG1764	response to oxidative stress
ID165_RS19305	COG1846	Transcriptional regulator
ID165_RS19310	COG3118	belongs to the thioredoxin family
ID165_RS19310	COG0492	ferredoxin-NADP+ reductase activity
ID165_RS19315	COG0583	DNA-binding transcription factor activity
ID165_RS19320	COG3015	lipoprotein NlpE involved in copper resistance
ID165_RS19370	COG1368	sulfuric ester hydrolase activity
ID165_RS19390	COG1629	transport
ID165_RS19390	COG4206	TonB-dependent receptor
ID165_RS19395	COG1968	undecaprenyl-diphosphatase activity
ID165_RS19400	COG0693	protein deglycase activity
ID165_RS19415	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS19415	COG2207	Transcriptional regulator
ID165_RS19420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ID165_RS19425	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS19430	COG3938	Belongs to the proline racemase family
ID165_RS19435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ID165_RS19445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ID165_RS19450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ID165_RS19455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID165_RS19460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ID165_RS19480	COG1216	Glycosyl transferase, family 2
ID165_RS19480	COG0438	transferase activity, transferring glycosyl groups
ID165_RS19515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID165_RS19530	COG0531	amino acid
ID165_RS19540	COG1104	cysteine desulfurase activity
ID165_RS19545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID165_RS19555	COG3956	TIGRFAM MazG family protein
ID165_RS19560	COG0251	oxidation-reduction process
ID165_RS19580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ID165_RS19595	COG0004	ammonium transporteR
ID165_RS19600	COG0347	Belongs to the P(II) protein family
ID165_RS19610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID165_RS19615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID165_RS19625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ID165_RS19630	COG0527	aspartate kinase activity
ID165_RS19655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ID165_RS19665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID165_RS19680	COG0778	Nitroreductase
ID165_RS19695	COG4585	Histidine kinase
ID165_RS19700	COG2197	response regulator
ID165_RS19710	COG0813	purine-nucleoside phosphorylase activity
ID165_RS19715	COG1054	Belongs to the UPF0176 family
ID165_RS19730	COG0284	orotidine-5'-phosphate decarboxylase activity
ID165_RS19775	COG0463	Glycosyl transferase, family 2
ID165_RS19795	COG4974	Belongs to the 'phage' integrase family
ID165_RS19800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ID165_RS19825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ID165_RS19835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID165_RS19845	COG3720	iron ion transport
ID165_RS19850	COG4771	TonB-dependent receptor
ID165_RS19860	COG0791	NLP P60 protein
ID165_RS19870	COG1181	Belongs to the D-alanine--D-alanine ligase family
ID165_RS19875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ID165_RS19885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ID165_RS19885	COG1648	precorrin-2 dehydrogenase activity
ID165_RS19895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID165_RS19905	COG0175	sulfate reduction
ID165_RS19910	COG0175	sulfate reduction
ID165_RS19920	COG1959	2 iron, 2 sulfur cluster binding
ID165_RS19925	COG0326	Molecular chaperone. Has ATPase activity
ID165_RS19955	COG1138	Cytochrome C-type biogenesis protein
ID165_RS19965	COG1137	ATPase activity
ID165_RS19970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ID165_RS19970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ID165_RS19975	COG2264	protein methyltransferase activity
ID165_RS19980	COG0149	triose-phosphate isomerase activity
ID165_RS19985	COG2137	regulation of response to DNA damage stimulus
ID165_RS20015	COG0515	serine threonine protein kinase
ID165_RS20015	COG2815	serine threonine protein kinase
ID165_RS20030	COG0423	glycine-tRNA ligase activity
ID165_RS20040	COG0673	inositol 2-dehydrogenase activity
ID165_RS20065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ID165_RS20075	COG0572	uridine kinase
ID165_RS20080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ID165_RS20095	COG0577	efflux transmembrane transporter activity
ID165_RS20100	COG0583	DNA-binding transcription factor activity
ID165_RS20115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ID165_RS20120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ID165_RS20125	COG0363	glucosamine-6-phosphate deaminase activity
ID165_RS20130	COG3588	fructose-bisphosphate aldolase
ID165_RS20170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ID165_RS20190	COG1595	DNA-templated transcription, initiation
ID165_RS20265	COG1704	LemA family
ID165_RS20290	COG0746	molybdenum cofactor guanylyltransferase activity
ID165_RS20295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ID165_RS20295	COG1648	precorrin-2 dehydrogenase activity
ID165_RS20305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID165_RS20310	COG0314	molybdopterin synthase activity
ID165_RS20315	COG0315	cyclic pyranopterin monophosphate synthase activity
ID165_RS20320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ID165_RS20335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ID165_RS20340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID165_RS20360	COG1629	transport
ID165_RS20385	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ID165_RS20385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID165_RS20400	COG0084	hydrolase, TatD family'
ID165_RS20405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ID165_RS20410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ID165_RS20430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ID165_RS20440	COG0367	asparagine synthase
ID165_RS20445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ID165_RS20455	COG2217	Heavy metal translocating P-type atpase
ID165_RS20485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ID165_RS20495	COG0297	glycogen (starch) synthase activity
ID165_RS20500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ID165_RS20505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ID165_RS20520	COG1960	acyl-CoA dehydrogenase activity
ID165_RS20530	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ID165_RS20550	COG1611	Belongs to the LOG family
ID165_RS20555	COG1388	LysM domain
ID165_RS20555	COG0741	lytic transglycosylase activity
ID165_RS20560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ID165_RS20565	COG3275	phosphorelay sensor kinase activity
ID165_RS20570	COG3279	Response regulator of the LytR AlgR family
ID165_RS20585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ID165_RS20590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ID165_RS20595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ID165_RS20600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ID165_RS20605	COG3177	Filamentation induced by cAMP protein fic
ID165_RS20640	COG0019	diaminopimelate decarboxylase activity
ID165_RS20655	COG4948	Mandelate Racemase Muconate Lactonizing
ID165_RS20680	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ID165_RS20685	COG1764	response to oxidative stress
ID165_RS20695	COG0438	transferase activity, transferring glycosyl groups
ID165_RS20700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ID165_RS20775	COG4191	Histidine kinase
ID165_RS20775	COG0784	Response regulator, receiver
ID165_RS20780	COG0531	amino acid
ID165_RS20785	COG0405	Gamma-glutamyltransferase
ID165_RS20800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ID165_RS20805	COG0071	Belongs to the small heat shock protein (HSP20) family
ID165_RS20815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ID165_RS20835	COG1629	transport
ID165_RS20850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID165_RS20850	COG0515	serine threonine protein kinase
ID165_RS20855	COG0673	inositol 2-dehydrogenase activity
ID165_RS20860	COG3622	Belongs to the hyi family
ID165_RS20870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ID165_RS20880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID165_RS20885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID165_RS20895	COG0438	transferase activity, transferring glycosyl groups
ID165_RS20925	COG0488	(ABC) transporter
ID165_RS20935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ID165_RS20955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ID165_RS20965	COG1472	Belongs to the glycosyl hydrolase 3 family
ID165_RS20970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ID165_RS20980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ID165_RS21000	COG0517	IMP dehydrogenase activity
ID165_RS21000	COG0516	GMP reductase activity
ID165_RS21005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID165_RS21005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID165_RS21015	COG2890	protein-(glutamine-N5) methyltransferase activity
ID165_RS21050	COG0662	Cupin 2, conserved barrel domain protein
ID165_RS21055	COG3844	kynureninase activity
ID165_RS21060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ID165_RS21065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ID165_RS21070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ID165_RS21100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ID165_RS21100	COG5479	isomerase activity
ID165_RS21105	COG2176	DNA-directed DNA polymerase activity
ID165_RS21120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ID165_RS21125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID165_RS21140	COG1477	protein flavinylation
ID165_RS21145	COG2255	four-way junction helicase activity
ID165_RS21155	COG4585	Histidine kinase
ID165_RS21175	COG0653	protein targeting
ID165_RS21180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ID165_RS21185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ID165_RS21210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID165_RS21235	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS21240	COG2318	DinB family
ID165_RS21260	COG0708	Exodeoxyribonuclease III
ID165_RS21265	COG2172	sigma factor antagonist activity
ID165_RS21270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ID165_RS21275	COG0445	tRNA wobble uridine modification
ID165_RS21290	COG1022	Amp-dependent synthetase and ligase
ID165_RS21300	COG1024	Enoyl-CoA hydratase
ID165_RS21300	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID165_RS21310	COG0183	Belongs to the thiolase family
ID165_RS21320	COG1960	acyl-CoA dehydrogenase activity
ID165_RS21330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ID165_RS21345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID165_RS21345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID165_RS21350	COG1956	GAF domain-containing protein
ID165_RS21360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ID165_RS21365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ID165_RS21375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ID165_RS21380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID165_RS21385	COG0569	domain protein
ID165_RS21390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ID165_RS21395	COG0038	chloride channel
ID165_RS21400	COG1090	epimerase
ID165_RS21430	COG3279	Response regulator of the LytR AlgR family
ID165_RS21445	COG0179	Fumarylacetoacetate (FAA) hydrolase
ID165_RS21455	COG0432	Pfam Uncharacterised protein family UPF0047
ID165_RS21465	COG3394	polysaccharide catabolic process
ID165_RS21500	COG2226	methyltransferase
ID165_RS21525	COG1283	sodium-dependent phosphate transmembrane transporter activity
ID165_RS21535	COG0590	tRNA wobble adenosine to inosine editing
ID165_RS21575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID165_RS21595	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ID165_RS21600	COG0217	transcriptional regulatory protein
ID165_RS21605	COG1252	NADH dehydrogenase
ID165_RS21620	COG0070	glutamate synthase
ID165_RS21620	COG0069	glutamate synthase activity
ID165_RS21620	COG0067	glutamate synthase
ID165_RS21630	COG0629	single-stranded DNA binding
ID165_RS21640	COG0776	regulation of translation
ID165_RS21650	COG1530	ribonuclease E activity
ID165_RS21670	COG3279	Response regulator of the LytR AlgR family
ID165_RS21675	COG3275	phosphorelay sensor kinase activity
ID165_RS21705	COG0346	lactoylglutathione lyase activity
ID165_RS21710	COG0514	ATP-dependent DNA helicase (RecQ)
ID165_RS21750	COG3292	Two component regulator propeller
ID165_RS21750	COG2205	protein histidine kinase activity
ID165_RS21750	COG0745	RESPONSE REGULATOR receiver
ID165_RS21755	COG4206	TonB-dependent receptor
ID165_RS21755	COG1629	transport
ID165_RS21765	COG1621	beta-fructofuranosidase activity
ID165_RS21770	COG2814	Major facilitator Superfamily
ID165_RS21825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID165_RS21845	COG0488	(ABC) transporter
ID165_RS21860	COG0642	Histidine kinase
ID165_RS21865	COG0745	RESPONSE REGULATOR receiver
ID165_RS21880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS21890	COG1538	Outer membrane efflux protein
ID165_RS21910	COG3250	beta-galactosidase activity
ID165_RS21925	COG3507	Belongs to the glycosyl hydrolase 43 family
ID165_RS21940	COG4771	TonB-dependent receptor
ID165_RS21945	COG0745	RESPONSE REGULATOR receiver
ID165_RS21945	COG2205	protein histidine kinase activity
ID165_RS21945	COG3292	Two component regulator propeller
ID165_RS21985	COG5564	TIM-barrel signal transduction protein
ID165_RS21990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ID165_RS21995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID165_RS21995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID165_RS22020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ID165_RS22030	COG0157	Belongs to the NadC ModD family
ID165_RS22040	COG0598	Magnesium transport protein CorA
ID165_RS22045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ID165_RS22085	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ID165_RS22085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID165_RS22090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ID165_RS22115	COG2133	pyrroloquinoline quinone binding
ID165_RS22120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ID165_RS22130	COG4464	protein tyrosine phosphatase activity
ID165_RS22145	COG1809	phosphosulfolactate synthase activity
ID165_RS22155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ID165_RS22165	COG0788	formyltetrahydrofolate deformylase activity
ID165_RS22175	COG0519	Catalyzes the synthesis of GMP from XMP
ID165_RS22185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID165_RS22190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ID165_RS22195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ID165_RS22220	COG1253	flavin adenine dinucleotide binding
ID165_RS22235	COG2154	pterin-4-alpha-carbinolamine dehydratase
ID165_RS22240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ID165_RS22265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ID165_RS22270	COG0805	protein transport
ID165_RS22275	COG0698	ribose 5-phosphate isomerase
ID165_RS22310	COG4302	ethanolamine ammonia-lyase activity
ID165_RS22315	COG4303	Ethanolamine ammonia lyase large subunit
ID165_RS22325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ID165_RS22330	COG4591	ABC-type transport system involved in lipoprotein release permease component
ID165_RS22340	COG1132	(ABC) transporter
ID165_RS22360	COG2353	YceI-like domain
ID165_RS22385	COG4771	TonB-dependent receptor
ID165_RS22410	COG1473	amidohydrolase
ID165_RS22420	COG1187	pseudouridine synthase activity
ID165_RS22425	COG0714	Associated with various cellular activities
ID165_RS22435	COG1629	transport
ID165_RS22435	COG4206	TonB-dependent receptor
ID165_RS22490	COG0300	oxidoreductase activity
ID165_RS22495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ID165_RS22525	COG0644	oxidoreductase
ID165_RS22535	COG3424	synthase
ID165_RS22545	COG0668	transmembrane transport
ID165_RS22560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID165_RS22565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ID165_RS22570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ID165_RS22590	COG1595	DNA-templated transcription, initiation
ID165_RS22605	COG1187	pseudouridine synthase activity
ID165_RS22615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ID165_RS22645	COG4974	Belongs to the 'phage' integrase family
ID165_RS22660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ID165_RS22665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ID165_RS22670	COG2095	MarC family integral membrane protein
ID165_RS22675	COG0328	RNA-DNA hybrid ribonuclease activity
ID165_RS22680	COG1373	ATPase (AAA superfamily
ID165_RS22705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ID165_RS22710	COG2226	methyltransferase
ID165_RS22720	COG4221	oxidoreductase activity
ID165_RS22735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ID165_RS22750	COG0697	spore germination
ID165_RS22755	COG1373	ATPase (AAA superfamily
ID165_RS22760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID165_RS22765	COG1266	CAAX protease self-immunity
ID165_RS22780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID165_RS22795	COG0688	phosphatidylethanolamine metabolic process
ID165_RS22815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ID165_RS22820	COG0612	Peptidase, M16
ID165_RS22825	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ID165_RS22830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ID165_RS22850	COG0596	Alpha beta hydrolase
ID165_RS22855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS22860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID165_RS22870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ID165_RS22880	COG2610	gluconate transmembrane transporter activity
ID165_RS22895	COG0556	nucleotide-excision repair
ID165_RS22910	COG0564	pseudouridine synthase activity
ID165_RS22920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ID165_RS22925	COG1381	Involved in DNA repair and RecF pathway recombination
ID165_RS22955	COG0772	Belongs to the SEDS family
ID165_RS22960	COG0768	penicillin binding
ID165_RS22975	COG1077	Cell shape determining protein MreB Mrl
ID165_RS22980	COG0779	Required for maturation of 30S ribosomal subunits
ID165_RS22985	COG0195	Participates in both transcription termination and antitermination
ID165_RS22985	COG2251	uridine kinase activity
ID165_RS23035	COG2271	Major facilitator Superfamily
ID165_RS23050	COG1966	Carbon starvation protein
ID165_RS23070	COG1629	transport
ID165_RS23085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ID165_RS23110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ID165_RS23115	COG1187	pseudouridine synthase activity
ID165_RS23135	COG1917	Cupin 2, conserved barrel domain protein
ID165_RS23135	COG4977	sequence-specific DNA binding
ID165_RS23145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID165_RS23155	COG3386	PFAM SMP-30 Gluconolaconase
ID165_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS23170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ID165_RS23175	COG0596	Alpha beta hydrolase
ID165_RS23180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ID165_RS23185	COG1610	YqeY-like protein
ID165_RS23195	COG0512	Glutamine amidotransferase of anthranilate synthase
ID165_RS23215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ID165_RS23220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ID165_RS23225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID165_RS23235	COG1960	acyl-CoA dehydrogenase activity
ID165_RS23250	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID165_RS23260	COG1073	alpha beta
ID165_RS23280	COG0587	DNA-directed DNA polymerase activity
ID165_RS23295	COG2807	transmembrane transport
ID165_RS23300	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ID165_RS23305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ID165_RS23375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID165_RS23390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ID165_RS23405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID165_RS23410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ID165_RS23425	COG1160	GTP binding
ID165_RS23430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ID165_RS23595	COG2217	Heavy metal translocating P-type atpase
ID165_RS23645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID165_RS23675	COG2226	methyltransferase
ID165_RS23680	COG0745	RESPONSE REGULATOR receiver
ID165_RS23680	COG2205	protein histidine kinase activity
ID165_RS23680	COG3292	Two component regulator propeller
ID165_RS23695	COG2132	Multicopper oxidase
ID165_RS23705	COG0531	amino acid
ID165_RS23745	COG2197	response regulator
ID165_RS23795	COG1629	transport
ID165_RS23795	COG4206	TonB-dependent receptor
ID165_RS23885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ID165_RS23895	COG0629	single-stranded DNA binding
ID165_RS24075	COG2169	Transcriptional regulator
ID165_RS24100	COG1674	ftsk spoiiie
ID165_RS24105	COG0167	dihydroorotate dehydrogenase activity
ID165_RS24115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID165_RS24115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID165_RS24120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ID165_RS24150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ID165_RS24155	COG2268	Band 7 protein
ID165_RS24175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID165_RS24185	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS24185	COG1506	peptidase
ID165_RS24185	COG4946	Tricorn protease homolog
ID165_RS24190	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ID165_RS24200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ID165_RS24220	COG0561	phosphatase activity
ID165_RS24240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ID165_RS24250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID165_RS24285	COG0460	homoserine dehydrogenase
ID165_RS24285	COG0527	aspartate kinase activity
ID165_RS24290	COG0083	homoserine kinase activity
ID165_RS24295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ID165_RS24320	COG2133	pyrroloquinoline quinone binding
ID165_RS24330	COG0527	aspartate kinase activity
ID165_RS24335	COG0673	inositol 2-dehydrogenase activity
ID165_RS24340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID165_RS24350	COG1162	GTPase activity
ID165_RS24360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ID165_RS24375	COG0438	transferase activity, transferring glycosyl groups
ID165_RS24390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID165_RS24395	COG0513	Belongs to the DEAD box helicase family
ID165_RS24400	COG1473	amidohydrolase
ID165_RS24405	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS24430	COG3118	belongs to the thioredoxin family
ID165_RS24450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ID165_RS24460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID165_RS24485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ID165_RS24500	COG3781	membrane
ID165_RS24505	COG0237	dephospho-CoA kinase activity
ID165_RS24515	COG1862	Preprotein translocase
ID165_RS24530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID165_RS24540	COG1132	(ABC) transporter
ID165_RS24550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID165_RS24555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID165_RS24565	COG1366	Belongs to the anti-sigma-factor antagonist family
ID165_RS24580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID165_RS24605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID165_RS24625	COG0322	excinuclease ABC activity
ID165_RS24630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ID165_RS24650	COG0356	it plays a direct role in the translocation of protons across the membrane
ID165_RS24655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID165_RS24660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ID165_RS24665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID165_RS24670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ID165_RS24675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ID165_RS24700	COG2755	lipolytic protein G-D-S-L family
ID165_RS24700	COG0657	acetylesterase activity
ID165_RS24710	COG1960	acyl-CoA dehydrogenase activity
ID165_RS24735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ID165_RS24740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ID165_RS24750	COG0475	glutathione-regulated potassium exporter activity
ID165_RS24790	COG1595	DNA-templated transcription, initiation
ID165_RS24800	COG2181	nitrate reductase activity
ID165_RS24800	COG0247	lactate metabolic process
ID165_RS24805	COG0247	lactate metabolic process
ID165_RS24805	COG2181	nitrate reductase activity
ID165_RS24815	COG2885	chlorophyll binding
ID165_RS24815	COG3047	cAMP biosynthetic process
ID165_RS24820	COG0492	ferredoxin-NADP+ reductase activity
ID165_RS24830	COG1902	pentaerythritol trinitrate reductase activity
ID165_RS24835	COG3682	Transcriptional regulator
ID165_RS24840	COG0501	Belongs to the peptidase M48B family
ID165_RS24845	COG2001	Belongs to the MraZ family
ID165_RS24850	COG0275	rRNA processing
ID165_RS24860	COG0768	penicillin binding
ID165_RS24865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ID165_RS24870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID165_RS24875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID165_RS24880	COG0772	Belongs to the SEDS family
ID165_RS24885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID165_RS24890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ID165_RS24905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ID165_RS24915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ID165_RS24925	COG1629	transport
ID165_RS24940	COG0567	Dehydrogenase, E1 component
ID165_RS24945	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID165_RS24960	COG1741	Belongs to the pirin family
ID165_RS24965	COG3153	acetyltransferase
ID165_RS24965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID165_RS24990	COG0542	response to heat
ID165_RS25000	COG4206	TonB-dependent receptor
ID165_RS25000	COG1629	transport
ID165_RS25020	COG0475	glutathione-regulated potassium exporter activity
ID165_RS25020	COG0589	response to stress
ID165_RS25045	COG0563	adenylate kinase activity
ID165_RS25050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ID165_RS25055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ID165_RS25060	COG0484	heat shock protein binding
ID165_RS25070	COG4152	abc transporter atp-binding protein
ID165_RS25075	COG1668	transmembrane transport
ID165_RS25080	COG0783	Belongs to the Dps family
ID165_RS25085	COG3852	Histidine kinase
ID165_RS25090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ID165_RS25095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID165_RS25100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ID165_RS25105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ID165_RS25115	COG1805	sodium ion transport
ID165_RS25125	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ID165_RS25130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ID165_RS25145	COG0823	Involved in the tonB-independent uptake of proteins
ID165_RS25150	COG0709	Synthesizes selenophosphate from selenide and ATP
ID165_RS25155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ID165_RS25160	COG3118	belongs to the thioredoxin family
ID165_RS25175	COG0357	Ribosomal RNA small subunit methyltransferase G
ID165_RS25180	COG1595	DNA-templated transcription, initiation
ID165_RS25190	COG0343	queuine tRNA-ribosyltransferase activity
ID165_RS25205	COG2337	Toxic component of a toxin-antitoxin (TA) module
ID165_RS25215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ID165_RS25220	COG0129	dihydroxy-acid dehydratase activity
ID165_RS25225	COG0028	Belongs to the TPP enzyme family
ID165_RS25235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ID165_RS25240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ID165_RS25245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ID165_RS25250	COG0066	3-isopropylmalate dehydratase activity
ID165_RS25280	COG0101	tRNA pseudouridine synthase activity
ID165_RS25290	COG0673	inositol 2-dehydrogenase activity
ID165_RS25315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID165_RS25320	COG1363	Peptidase, m42
ID165_RS25325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID165_RS25375	COG0359	binds to the 23S rRNA
ID165_RS25380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ID165_RS25385	COG0360	Binds together with S18 to 16S ribosomal RNA
ID165_RS25395	COG0500	methyltransferase
ID165_RS25410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ID165_RS25415	COG0681	Belongs to the peptidase S26 family
ID165_RS25420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ID165_RS25430	COG1475	DNA binding
ID165_RS25435	COG1192	Involved in chromosome partitioning
ID165_RS25450	COG0736	holo-[acyl-carrier-protein] synthase activity
ID165_RS25490	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS25495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID165_RS25500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID165_RS25540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID165_RS25550	COG0726	polysaccharide deacetylase
ID165_RS25570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ID165_RS25570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID165_RS25580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ID165_RS25585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ID165_RS25605	COG0557	exoribonuclease II activity
ID165_RS25620	COG0321	lipoyl(octanoyl) transferase activity
ID165_RS25625	COG0792	nuclease activity
ID165_RS25640	COG0436	Aminotransferase
ID165_RS25650	COG1216	Glycosyl transferase, family 2
ID165_RS25660	COG1012	belongs to the aldehyde dehydrogenase family
ID165_RS25670	COG0316	Belongs to the HesB IscA family
ID165_RS25695	COG1490	D-aminoacyl-tRNA deacylase activity
ID165_RS25700	COG1119	ATPase activity
ID165_RS25725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ID165_RS25745	COG1694	Mazg nucleotide pyrophosphohydrolase
ID165_RS25755	COG2045	Belongs to the ComB family
ID165_RS25760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ID165_RS25765	COG0316	Belongs to the HesB IscA family
ID165_RS25770	COG0346	lactoylglutathione lyase activity
ID165_RS25775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ID165_RS25780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ID165_RS25785	COG0052	Belongs to the universal ribosomal protein uS2 family
ID165_RS25790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ID165_RS25800	COG0564	pseudouridine synthase activity
ID165_RS25805	COG5002	protein histidine kinase activity
ID165_RS25810	COG0745	RESPONSE REGULATOR receiver
ID165_RS25820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ID165_RS25830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ID165_RS25835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ID165_RS25850	COG3279	Response regulator of the LytR AlgR family
ID165_RS25865	COG0488	(ABC) transporter
ID165_RS25885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID165_RS25970	COG1408	metallophosphoesterase
ID165_RS25975	COG0436	Aminotransferase
ID165_RS25990	COG0268	Binds directly to 16S ribosomal RNA
ID165_RS25995	COG2003	Belongs to the UPF0758 family
ID165_RS26020	COG1418	mRNA catabolic process
ID165_RS26035	COG0246	Mannitol dehydrogenase
ID165_RS26040	COG1609	Transcriptional regulator
ID165_RS26045	COG1028	Short-chain dehydrogenase reductase Sdr
ID165_RS26050	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ID165_RS26060	COG4771	TonB-dependent receptor
ID165_RS26065	COG0561	phosphatase activity
ID165_RS26070	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ID165_RS26085	COG2755	lipolytic protein G-D-S-L family
ID165_RS26095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ID165_RS26120	COG2721	sulfolactate sulfo-lyase activity
ID165_RS26130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ID165_RS26140	COG0488	(ABC) transporter
ID165_RS26145	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ID165_RS26155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ID165_RS26165	COG1136	(ABC) transporter
ID165_RS26165	COG0577	efflux transmembrane transporter activity
ID165_RS26195	COG1999	signal sequence binding
ID165_RS26200	COG1981	membrane
ID165_RS26210	COG1703	isobutyryl-CoA mutase activity
ID165_RS26240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID165_RS26245	COG1120	ATPase activity
ID165_RS26255	COG1131	(ABC) transporter
ID165_RS26265	COG1538	Outer membrane efflux protein
ID165_RS26285	COG2885	chlorophyll binding
ID165_RS26365	COG0745	RESPONSE REGULATOR receiver
ID165_RS26380	COG3237	CsbD-like
ID165_RS26405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ID165_RS26415	COG0492	ferredoxin-NADP+ reductase activity
ID165_RS26470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ID165_RS26470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ID165_RS26475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly