locus-tag	class	description
PCI15_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PCI15_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PCI15_RS00020	COG0187	DNA topoisomerase II activity
PCI15_RS00035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PCI15_RS00040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PCI15_RS00055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PCI15_RS00060	COG1522	sequence-specific DNA binding
PCI15_RS00065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PCI15_RS00065	COG4651	solute:proton antiporter activity
PCI15_RS00070	COG0508	dehydrogenase complex catalyzes the overall conversion of
PCI15_RS00070	COG0596	Alpha beta hydrolase
PCI15_RS00085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS00095	COG0583	DNA-binding transcription factor activity
PCI15_RS00100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PCI15_RS00110	COG0840	transmembrane signaling receptor activity
PCI15_RS00165	COG4251	negative regulation of phosphorylation
PCI15_RS00165	COG3706	GGDEF domain
PCI15_RS00165	COG2203	Gaf domain
PCI15_RS00165	COG5001	Diguanylate cyclase
PCI15_RS00170	COG0702	epimerase
PCI15_RS00175	COG0583	DNA-binding transcription factor activity
PCI15_RS00185	COG0730	response to heat
PCI15_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PCI15_RS00200	COG0751	glycine-tRNA ligase activity
PCI15_RS00205	COG0752	glycyl-tRNA synthetase alpha subunit
PCI15_RS00220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PCI15_RS00225	COG0569	domain protein
PCI15_RS00230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PCI15_RS00235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PCI15_RS00240	COG0242	peptide deformylase activity
PCI15_RS00250	COG0758	DNA mediated transformation
PCI15_RS00255	COG0009	L-threonylcarbamoyladenylate synthase
PCI15_RS00265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PCI15_RS00270	COG1067	ATP-dependent peptidase activity
PCI15_RS00275	COG1744	ABC transporter substrate-binding protein PnrA-like
PCI15_RS00280	COG3845	ABC transporter
PCI15_RS00290	COG1079	Belongs to the binding-protein-dependent transport system permease family
PCI15_RS00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PCI15_RS00310	COG0501	Belongs to the peptidase M48B family
PCI15_RS00320	COG5265	(ABC) transporter
PCI15_RS00330	COG0583	DNA-binding transcription factor activity
PCI15_RS00355	COG0583	DNA-binding transcription factor activity
PCI15_RS00385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PCI15_RS00400	COG0107	imidazoleglycerol-phosphate synthase activity
PCI15_RS00405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PCI15_RS00410	COG0131	Imidazoleglycerol-phosphate dehydratase
PCI15_RS00420	COG1194	a g-specific adenine glycosylase
PCI15_RS00435	COG1959	2 iron, 2 sulfur cluster binding
PCI15_RS00485	COG0625	glutathione transferase activity
PCI15_RS00500	COG2358	TRAP transporter, solute receptor (TAXI family
PCI15_RS00530	COG3177	Filamentation induced by cAMP protein fic
PCI15_RS00535	COG0784	Response regulator, receiver
PCI15_RS00535	COG3437	response regulator, receiver
PCI15_RS00550	COG0784	Response regulator, receiver
PCI15_RS00550	COG5002	protein histidine kinase activity
PCI15_RS00550	COG2205	protein histidine kinase activity
PCI15_RS00560	COG0405	Gamma-glutamyltransferase
PCI15_RS00585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PCI15_RS00590	COG1561	YicC-like family, N-terminal region
PCI15_RS00595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PCI15_RS00615	COG0443	Heat shock 70 kDa protein
PCI15_RS00630	COG2010	Cytochrome c
PCI15_RS00645	COG0583	DNA-binding transcription factor activity
PCI15_RS00665	COG0583	DNA-binding transcription factor activity
PCI15_RS00675	COG1418	mRNA catabolic process
PCI15_RS00680	COG0583	DNA-binding transcription factor activity
PCI15_RS00695	COG1126	abc transporter atp-binding protein
PCI15_RS00700	COG2423	ornithine cyclodeaminase activity
PCI15_RS00715	COG0010	Belongs to the arginase family
PCI15_RS00740	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS00760	COG4589	Belongs to the CDS family
PCI15_RS00775	COG2358	TRAP transporter, solute receptor (TAXI family
PCI15_RS00800	COG0837	glucose binding
PCI15_RS00800	COG1737	Transcriptional regulator
PCI15_RS00805	COG1250	3-hydroxyacyl-CoA dehydrogenase
PCI15_RS00810	COG1024	Enoyl-CoA hydratase
PCI15_RS00815	COG1511	domain protein
PCI15_RS00815	COG3264	Mechanosensitive ion channel
PCI15_RS00840	COG1120	ATPase activity
PCI15_RS00845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS00850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PCI15_RS00855	COG4206	TonB-dependent receptor
PCI15_RS00865	COG0708	Exodeoxyribonuclease III
PCI15_RS00890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PCI15_RS00900	COG2814	Major facilitator Superfamily
PCI15_RS01020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PCI15_RS01025	COG0735	belongs to the Fur family
PCI15_RS01030	COG1121	(ABC) transporter
PCI15_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PCI15_RS01040	COG0697	spore germination
PCI15_RS01050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PCI15_RS01055	COG0572	uridine kinase
PCI15_RS01060	COG2373	Large extracellular alpha-helical protein
PCI15_RS01065	COG4953	penicillin-binding protein 1C
PCI15_RS01070	COG1917	Cupin 2, conserved barrel domain protein
PCI15_RS01070	COG4977	sequence-specific DNA binding
PCI15_RS01085	COG0840	transmembrane signaling receptor activity
PCI15_RS01105	COG2205	protein histidine kinase activity
PCI15_RS01120	COG2818	Glycosylase
PCI15_RS01135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PCI15_RS01145	COG0745	RESPONSE REGULATOR receiver
PCI15_RS01150	COG2205	protein histidine kinase activity
PCI15_RS01155	COG4452	Inner membrane protein CreD
PCI15_RS01165	COG0501	Belongs to the peptidase M48B family
PCI15_RS01195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PCI15_RS01200	COG4181	ATPase activity
PCI15_RS01215	COG0583	DNA-binding transcription factor activity
PCI15_RS01220	COG1160	GTP binding
PCI15_RS01245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PCI15_RS01245	COG0678	peroxiredoxin activity
PCI15_RS01250	COG1760	l-serine dehydratase
PCI15_RS01270	COG4176	ABC-type proline glycine betaine transport system permease component
PCI15_RS01275	COG3448	diguanylate cyclase activity
PCI15_RS01275	COG4175	Glycine betaine
PCI15_RS01285	COG0583	DNA-binding transcription factor activity
PCI15_RS01295	COG0745	RESPONSE REGULATOR receiver
PCI15_RS01320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS01320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS01325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS01330	COG3383	formate dehydrogenase (NAD+) activity
PCI15_RS01345	COG0251	oxidation-reduction process
PCI15_RS01355	COG0733	neurotransmitter:sodium symporter activity
PCI15_RS01375	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PCI15_RS01380	COG3706	GGDEF domain
PCI15_RS01380	COG2203	Gaf domain
PCI15_RS01380	COG4251	negative regulation of phosphorylation
PCI15_RS01380	COG5001	Diguanylate cyclase
PCI15_RS01385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PCI15_RS01460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PCI15_RS01495	COG0494	nUDIX hydrolase
PCI15_RS01500	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS01510	COG0583	DNA-binding transcription factor activity
PCI15_RS01525	COG0840	transmembrane signaling receptor activity
PCI15_RS01530	COG0583	DNA-binding transcription factor activity
PCI15_RS01535	COG5598	trimethylamine methyltransferase
PCI15_RS01545	COG2252	PERMEase
PCI15_RS01555	COG3360	Dodecin
PCI15_RS01580	COG1760	l-serine dehydratase
PCI15_RS01620	COG0583	DNA-binding transcription factor activity
PCI15_RS01625	COG2217	Heavy metal translocating P-type atpase
PCI15_RS01645	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS01655	COG0011	TIGRFAM Protein of
PCI15_RS01670	COG2313	pseudouridylate synthase activity
PCI15_RS01675	COG1522	sequence-specific DNA binding
PCI15_RS01675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PCI15_RS01680	COG1522	sequence-specific DNA binding
PCI15_RS01685	COG0010	Belongs to the arginase family
PCI15_RS01690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS01700	COG1522	sequence-specific DNA binding
PCI15_RS01715	COG1653	transport
PCI15_RS01735	COG0069	glutamate synthase activity
PCI15_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS01770	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS01815	COG1609	Transcriptional regulator
PCI15_RS01820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS01825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS01830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS01845	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS01860	COG1132	(ABC) transporter
PCI15_RS01870	COG1335	isochorismatase
PCI15_RS01880	COG0583	DNA-binding transcription factor activity
PCI15_RS01895	COG1368	sulfuric ester hydrolase activity
PCI15_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS01905	COG4597	amino acid ABC transporter
PCI15_RS01910	COG0765	amino acid transport
PCI15_RS01915	COG1126	abc transporter atp-binding protein
PCI15_RS01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS01925	COG2205	protein histidine kinase activity
PCI15_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS01965	COG0513	Belongs to the DEAD box helicase family
PCI15_RS01970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PCI15_RS01975	COG2154	pterin-4-alpha-carbinolamine dehydratase
PCI15_RS01990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PCI15_RS01995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PCI15_RS02030	COG1309	transcriptional regulator
PCI15_RS02050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PCI15_RS02055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PCI15_RS02060	COG0501	Belongs to the peptidase M48B family
PCI15_RS02065	COG0742	ribosomal rna small subunit methyltransferase
PCI15_RS02075	COG0552	protein localization to endoplasmic reticulum
PCI15_RS02080	COG2884	Cell division ATP-binding protein ftsE
PCI15_RS02085	COG2177	Part of the ABC transporter FtsEX involved in
PCI15_RS02095	COG2363	Small membrane protein
PCI15_RS02110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PCI15_RS02120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PCI15_RS02125	COG2379	hydroxypyruvate reductase
PCI15_RS02130	COG3437	response regulator, receiver
PCI15_RS02130	COG2770	Histidine kinase
PCI15_RS02135	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PCI15_RS02165	COG0501	Belongs to the peptidase M48B family
PCI15_RS02170	COG4269	membrane
PCI15_RS02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PCI15_RS02175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PCI15_RS02185	COG0306	phosphate transporter
PCI15_RS02190	COG1392	Phosphate transport regulator
PCI15_RS02195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PCI15_RS02205	COG0626	cystathionine gamma-synthase activity
PCI15_RS02210	COG2814	Major facilitator Superfamily
PCI15_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS02225	COG1024	Enoyl-CoA hydratase
PCI15_RS02230	COG2814	Major facilitator Superfamily
PCI15_RS02240	COG0824	Thioesterase
PCI15_RS02240	COG1250	3-hydroxyacyl-CoA dehydrogenase
PCI15_RS02245	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS02265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PCI15_RS02270	COG2194	sulfuric ester hydrolase activity
PCI15_RS02280	COG0859	PFAM glycosyl transferase family 9
PCI15_RS02305	COG0515	serine threonine protein kinase
PCI15_RS02315	COG0297	glycogen (starch) synthase activity
PCI15_RS02335	COG1560	Kdo2-lipid A biosynthetic process
PCI15_RS02340	COG1132	(ABC) transporter
PCI15_RS02355	COG0667	Aldo Keto reductase
PCI15_RS02365	COG1519	Transferase
PCI15_RS02370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PCI15_RS02375	COG1965	Belongs to the frataxin family
PCI15_RS02380	COG5001	Diguanylate cyclase
PCI15_RS02380	COG3706	GGDEF domain
PCI15_RS02380	COG2203	Gaf domain
PCI15_RS02380	COG4251	negative regulation of phosphorylation
PCI15_RS02395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PCI15_RS02405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PCI15_RS02430	COG0494	nUDIX hydrolase
PCI15_RS02435	COG1011	Hydrolase
PCI15_RS02440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PCI15_RS02445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PCI15_RS02450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PCI15_RS02465	COG2188	Transcriptional regulator
PCI15_RS02475	COG2986	histidine ammonia-lyase
PCI15_RS02485	COG1228	amidohydrolase
PCI15_RS02510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PCI15_RS02530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PCI15_RS02535	COG1522	sequence-specific DNA binding
PCI15_RS02550	COG0315	cyclic pyranopterin monophosphate synthase activity
PCI15_RS02560	COG1983	PspC domain protein
PCI15_RS02570	COG1842	Phage shock protein A
PCI15_RS02575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PCI15_RS02585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PCI15_RS02590	COG0142	geranyltranstransferase activity
PCI15_RS02595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PCI15_RS02600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PCI15_RS02605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PCI15_RS02610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PCI15_RS02615	COG0268	Binds directly to 16S ribosomal RNA
PCI15_RS02620	COG0728	peptidoglycan biosynthetic process
PCI15_RS02625	COG0196	riboflavin kinase activity
PCI15_RS02630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PCI15_RS02635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PCI15_RS02640	COG1047	Peptidyl-prolyl cis-trans
PCI15_RS02665	COG4969	Belongs to the N-Me-Phe pilin family
PCI15_RS02745	COG0583	DNA-binding transcription factor activity
PCI15_RS02750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PCI15_RS02755	COG2207	Transcriptional regulator
PCI15_RS02770	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PCI15_RS02775	COG1120	ATPase activity
PCI15_RS02875	COG0582	viral genome integration into host DNA
PCI15_RS02885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PCI15_RS02890	COG2867	negative regulation of translational initiation
PCI15_RS02895	COG2914	Belongs to the UPF0125 (RnfH) family
PCI15_RS02905	COG0735	belongs to the Fur family
PCI15_RS02910	COG0497	DNA recombination
PCI15_RS02915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PCI15_RS02920	COG0443	Heat shock 70 kDa protein
PCI15_RS02930	COG1045	serine acetyltransferase
PCI15_RS02935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PCI15_RS02955	COG0494	nUDIX hydrolase
PCI15_RS02965	COG4536	flavin adenine dinucleotide binding
PCI15_RS02975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PCI15_RS02980	COG0228	four-way junction DNA binding
PCI15_RS02985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PCI15_RS02990	COG0336	Belongs to the RNA methyltransferase TrmD family
PCI15_RS02995	COG0335	large ribosomal subunit rRNA binding
PCI15_RS03010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PCI15_RS03025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PCI15_RS03030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PCI15_RS03040	COG0840	transmembrane signaling receptor activity
PCI15_RS03045	COG5001	Diguanylate cyclase
PCI15_RS03045	COG3300	MHYT domain
PCI15_RS03050	COG0494	nUDIX hydrolase
PCI15_RS03095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PCI15_RS03100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PCI15_RS03110	COG0069	glutamate synthase activity
PCI15_RS03110	COG0070	glutamate synthase
PCI15_RS03110	COG0067	glutamate synthase
PCI15_RS03115	COG0493	'glutamate synthase
PCI15_RS03120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PCI15_RS03125	COG0288	reversible hydration of carbon dioxide
PCI15_RS03135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PCI15_RS03145	COG0488	(ABC) transporter
PCI15_RS03150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PCI15_RS03155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PCI15_RS03155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PCI15_RS03170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PCI15_RS03175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PCI15_RS03180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PCI15_RS03185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PCI15_RS03210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PCI15_RS03215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PCI15_RS03220	COG0142	geranyltranstransferase activity
PCI15_RS03230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PCI15_RS03235	COG1360	Flagellar Motor Protein
PCI15_RS03260	COG2198	Histidine kinase
PCI15_RS03260	COG0643	Histidine kinase
PCI15_RS03265	COG0835	chemotaxis
PCI15_RS03270	COG0840	transmembrane signaling receptor activity
PCI15_RS03270	COG0840	transmembrane signaling receptor activity
PCI15_RS03280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PCI15_RS03285	COG2201	protein-glutamate methylesterase activity
PCI15_RS03290	COG0840	transmembrane signaling receptor activity
PCI15_RS03300	COG0745	RESPONSE REGULATOR receiver
PCI15_RS03305	COG2113	Glycine betaine
PCI15_RS03310	COG3713	MltA-interacting MipA family protein
PCI15_RS03315	COG0642	Histidine kinase
PCI15_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PCI15_RS03360	COG3181	Tripartite tricarboxylate transporter family receptor
PCI15_RS03365	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS03370	COG0318	PFAM AMP-dependent synthetase and ligase
PCI15_RS03380	COG0583	DNA-binding transcription factor activity
PCI15_RS03385	COG1279	arginine transmembrane transporter activity
PCI15_RS03405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS03410	COG0583	DNA-binding transcription factor activity
PCI15_RS03440	COG2226	methyltransferase
PCI15_RS03445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PCI15_RS03455	COG1393	Belongs to the ArsC family
PCI15_RS03460	COG0436	Aminotransferase
PCI15_RS03495	COG3008	intermembrane lipid transfer
PCI15_RS03500	COG2995	paraquat-inducible protein a
PCI15_RS03505	COG2995	paraquat-inducible protein a
PCI15_RS03515	COG1047	Peptidyl-prolyl cis-trans
PCI15_RS03545	COG0716	FMN binding
PCI15_RS03550	COG4771	TonB-dependent receptor
PCI15_RS03565	COG1917	Cupin 2, conserved barrel domain protein
PCI15_RS03565	COG2169	Transcriptional regulator
PCI15_RS03570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PCI15_RS03575	COG0084	hydrolase, TatD family'
PCI15_RS03585	COG0784	Response regulator, receiver
PCI15_RS03585	COG2205	protein histidine kinase activity
PCI15_RS03590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PCI15_RS03600	COG2885	chlorophyll binding
PCI15_RS03625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PCI15_RS03630	COG0024	Methionine aminopeptidase
PCI15_RS03635	COG0052	Belongs to the universal ribosomal protein uS2 family
PCI15_RS03640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PCI15_RS03645	COG0528	UMP kinase activity
PCI15_RS03650	COG0233	cytoplasmic translational termination
PCI15_RS03655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PCI15_RS03660	COG0575	Belongs to the CDS family
PCI15_RS03680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PCI15_RS03685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PCI15_RS03690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PCI15_RS03700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PCI15_RS03705	COG0587	DNA-directed DNA polymerase activity
PCI15_RS03710	COG0825	malonyl-CoA metabolic process
PCI15_RS03715	COG0037	tRNA processing
PCI15_RS03720	COG0504	CTP synthase activity
PCI15_RS03725	COG0148	phosphopyruvate hydratase activity
PCI15_RS03730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PCI15_RS03735	COG0585	pseudouridine synthase activity
PCI15_RS03740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PCI15_RS03745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PCI15_RS03770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PCI15_RS03775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PCI15_RS03790	COG2204	response regulator
PCI15_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PCI15_RS03810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PCI15_RS03815	COG0436	Aminotransferase
PCI15_RS03820	COG1489	DNA binding
PCI15_RS03840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PCI15_RS03850	COG2010	Cytochrome c
PCI15_RS03865	COG1845	cytochrome c oxidase, subunit III
PCI15_RS03875	COG0714	Associated with various cellular activities
PCI15_RS03890	COG1648	precorrin-2 dehydrogenase activity
PCI15_RS03890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PCI15_RS03920	COG0535	radical SAM domain protein
PCI15_RS03930	COG2010	Cytochrome c
PCI15_RS03940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PCI15_RS03950	COG1234	tRNA 3'-trailer cleavage
PCI15_RS03960	COG1283	sodium-dependent phosphate transmembrane transporter activity
PCI15_RS03965	COG4172	Belongs to the ABC transporter superfamily
PCI15_RS03970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PCI15_RS03975	COG0601	transmembrane transport
PCI15_RS03985	COG0583	DNA-binding transcription factor activity
PCI15_RS03995	COG3220	belongs to the UPF0276 family
PCI15_RS04015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PCI15_RS04020	COG0352	thiamine-phosphate diphosphorylase activity
PCI15_RS04025	COG0038	chloride channel
PCI15_RS04030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PCI15_RS04035	COG0316	Belongs to the HesB IscA family
PCI15_RS04040	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PCI15_RS04045	COG0739	heme binding
PCI15_RS04075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PCI15_RS04100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PCI15_RS04105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PCI15_RS04125	COG0358	DNA primase activity
PCI15_RS04135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PCI15_RS04140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PCI15_RS04145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PCI15_RS04150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PCI15_RS04155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PCI15_RS04155	COG0302	gtp cyclohydrolase
PCI15_RS04160	COG1704	LemA family
PCI15_RS04165	COG0501	Belongs to the peptidase M48B family
PCI15_RS04170	COG0617	tRNA 3'-terminal CCA addition
PCI15_RS04175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PCI15_RS04180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PCI15_RS04185	COG2967	ApaG domain
PCI15_RS04190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PCI15_RS04195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PCI15_RS04205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PCI15_RS04210	COG3178	'Phosphotransferase
PCI15_RS04215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PCI15_RS04220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PCI15_RS04230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PCI15_RS04235	COG0546	phosphoglycolate phosphatase activity
PCI15_RS04240	COG0523	cobalamin synthesis protein
PCI15_RS04260	COG1846	Transcriptional regulator
PCI15_RS04275	COG4175	Glycine betaine
PCI15_RS04275	COG0517	IMP dehydrogenase activity
PCI15_RS04280	COG0583	DNA-binding transcription factor activity
PCI15_RS04295	COG2133	pyrroloquinoline quinone binding
PCI15_RS04300	COG2346	COG2346, Truncated hemoglobins
PCI15_RS04310	COG0583	DNA-binding transcription factor activity
PCI15_RS04315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS04320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS04320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS04325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS04325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS04355	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS04360	COG0583	DNA-binding transcription factor activity
PCI15_RS04380	COG0006	proline dipeptidase activity
PCI15_RS04385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PCI15_RS04415	COG1396	sequence-specific DNA binding
PCI15_RS04420	COG1063	alcohol dehydrogenase
PCI15_RS04465	COG3852	Histidine kinase
PCI15_RS04475	COG1858	cytochrome C peroxidase
PCI15_RS04480	COG1858	cytochrome C peroxidase
PCI15_RS04490	COG0243	molybdopterin cofactor binding
PCI15_RS04505	COG3781	membrane
PCI15_RS04515	COG0512	Glutamine amidotransferase of anthranilate synthase
PCI15_RS04520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PCI15_RS04525	COG0134	indole-3-glycerol-phosphate synthase activity
PCI15_RS04530	COG1765	OsmC-like protein
PCI15_RS04540	COG0360	Binds together with S18 to 16S ribosomal RNA
PCI15_RS04545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PCI15_RS04550	COG0359	binds to the 23S rRNA
PCI15_RS04555	COG0305	Participates in initiation and elongation during chromosome replication
PCI15_RS04585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PCI15_RS04600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PCI15_RS04605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PCI15_RS04615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PCI15_RS04620	COG0768	penicillin binding
PCI15_RS04625	COG0772	Belongs to the SEDS family
PCI15_RS04630	COG2951	lytic endotransglycosylase activity
PCI15_RS04640	COG1686	Belongs to the peptidase S11 family
PCI15_RS04650	COG2921	Belongs to the UPF0250 family
PCI15_RS04655	COG0321	lipoyl(octanoyl) transferase activity
PCI15_RS04710	COG3048	D-serine ammonia-lyase activity
PCI15_RS04715	COG1466	dna polymerase III delta subunit
PCI15_RS04725	COG0495	leucyl-tRNA aminoacylation
PCI15_RS04735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PCI15_RS04740	COG4535	Mg2 and Co2 transporter CorC
PCI15_RS04745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PCI15_RS04750	COG1702	phosphate starvation-inducible protein PhoH
PCI15_RS04755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PCI15_RS04765	COG5001	Diguanylate cyclase
PCI15_RS04765	COG5002	protein histidine kinase activity
PCI15_RS04770	COG1509	lysine 2,3-aminomutase activity
PCI15_RS04775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PCI15_RS04790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PCI15_RS04810	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PCI15_RS04825	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS04830	COG1177	transmembrane transport
PCI15_RS04835	COG1176	ABC-type spermidine putrescine transport system, permease component I
PCI15_RS04845	COG3842	ATPase activity
PCI15_RS04850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS04855	COG0415	Belongs to the DNA photolyase family
PCI15_RS04860	COG3272	Protein of unknown function (DUF1722)
PCI15_RS04865	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PCI15_RS04880	COG2153	protein acetylation
PCI15_RS04910	COG1115	amino acid carrier protein
PCI15_RS04915	COG0488	(ABC) transporter
PCI15_RS04920	COG3148	PFAM DTW domain containing protein
PCI15_RS04940	COG5598	trimethylamine methyltransferase
PCI15_RS04950	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS04965	COG2204	response regulator
PCI15_RS04970	COG4191	Histidine kinase
PCI15_RS04975	COG2223	nitrite transmembrane transporter activity
PCI15_RS04990	COG0702	epimerase
PCI15_RS05000	COG2944	sequence-specific DNA binding
PCI15_RS05025	COG0840	transmembrane signaling receptor activity
PCI15_RS05040	COG0525	valine-tRNA ligase activity
PCI15_RS05055	COG0795	lipopolysaccharide-transporting ATPase activity
PCI15_RS05060	COG0795	lipopolysaccharide-transporting ATPase activity
PCI15_RS05070	COG2391	methyltransferase activity
PCI15_RS05095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PCI15_RS05100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PCI15_RS05110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PCI15_RS05115	COG0697	spore germination
PCI15_RS05135	COG0688	phosphatidylethanolamine metabolic process
PCI15_RS05150	COG1162	GTPase activity
PCI15_RS05155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PCI15_RS05160	COG0840	transmembrane signaling receptor activity
PCI15_RS05170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PCI15_RS05170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PCI15_RS05175	COG0802	atpase or kinase
PCI15_RS05180	COG0860	N-Acetylmuramoyl-L-alanine amidase
PCI15_RS05185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PCI15_RS05200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PCI15_RS05205	COG0330	HflC and HflK could
PCI15_RS05210	COG0330	HflC and HflK could
PCI15_RS05220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PCI15_RS05225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PCI15_RS05245	COG1104	cysteine desulfurase activity
PCI15_RS05255	COG0316	Belongs to the HesB IscA family
PCI15_RS05280	COG0105	UTP biosynthetic process
PCI15_RS05285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PCI15_RS05290	COG3063	Type IV pilus biogenesis stability protein PilW
PCI15_RS05300	COG0124	histidyl-tRNA synthetase
PCI15_RS05305	COG2976	Protein conserved in bacteria
PCI15_RS05315	COG1160	GTP binding
PCI15_RS05350	COG1335	isochorismatase
PCI15_RS05360	COG1473	amidohydrolase
PCI15_RS05365	COG0697	spore germination
PCI15_RS05405	COG3086	response to oxidative stress
PCI15_RS05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PCI15_RS05415	COG0481	GTPase activity
PCI15_RS05430	COG0571	ribonuclease III activity
PCI15_RS05435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PCI15_RS05445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PCI15_RS05460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PCI15_RS05465	COG3956	TIGRFAM MazG family protein
PCI15_RS05475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PCI15_RS05480	COG0563	adenylate kinase activity
PCI15_RS05485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS05490	COG4597	amino acid ABC transporter
PCI15_RS05495	COG0765	amino acid transport
PCI15_RS05500	COG1126	abc transporter atp-binding protein
PCI15_RS05505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PCI15_RS05510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PCI15_RS05515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PCI15_RS05525	COG0537	adenosine 5'-monophosphoramidase activity
PCI15_RS05530	COG2719	SpoVR family
PCI15_RS05535	COG2718	Belongs to the UPF0229 family
PCI15_RS05540	COG2766	serine protein kinase
PCI15_RS05550	COG0022	dehydrogenase e1 component
PCI15_RS05580	COG2350	Protein conserved in bacteria
PCI15_RS05585	COG2917	probably involved in intracellular septation
PCI15_RS05595	COG0009	L-threonylcarbamoyladenylate synthase
PCI15_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS05630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PCI15_RS05640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PCI15_RS05645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PCI15_RS05650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PCI15_RS05660	COG0776	regulation of translation
PCI15_RS05670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PCI15_RS05675	COG0284	orotidine-5'-phosphate decarboxylase activity
PCI15_RS05680	COG1555	photosystem II stabilization
PCI15_RS05690	COG3220	belongs to the UPF0276 family
PCI15_RS05710	COG1720	tRNA m6t6A37 methyltransferase activity
PCI15_RS05715	COG1040	competence protein
PCI15_RS05720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PCI15_RS05740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PCI15_RS05755	COG0596	Alpha beta hydrolase
PCI15_RS05760	COG0545	Peptidyl-prolyl cis-trans isomerase
PCI15_RS05765	COG1570	exodeoxyribonuclease VII activity
PCI15_RS05780	COG0590	tRNA wobble adenosine to inosine editing
PCI15_RS05790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PCI15_RS05805	COG0151	Belongs to the GarS family
PCI15_RS05820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PCI15_RS05845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PCI15_RS05855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PCI15_RS05865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PCI15_RS05870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PCI15_RS05875	COG0154	amidase activity
PCI15_RS05880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PCI15_RS05885	COG1077	Cell shape determining protein MreB Mrl
PCI15_RS05890	COG1792	Involved in formation and maintenance of cell shape
PCI15_RS05895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PCI15_RS05900	COG0424	maF-like protein
PCI15_RS05920	COG2239	Acts as a magnesium transporter
PCI15_RS05930	COG1660	Displays ATPase and GTPase activities
PCI15_RS05950	COG1137	ATPase activity
PCI15_RS05980	COG1127	ABC transporter
PCI15_RS05985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PCI15_RS05990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PCI15_RS06005	COG5007	Belongs to the BolA IbaG family
PCI15_RS06010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PCI15_RS06015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PCI15_RS06020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PCI15_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS06035	COG3030	protein affecting phage T7 exclusion by the F plasmid
PCI15_RS06040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PCI15_RS06045	COG0459	protein refolding
PCI15_RS06080	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PCI15_RS06090	COG1819	glycosyl
PCI15_RS06095	COG0254	rRNA binding
PCI15_RS06100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PCI15_RS06105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PCI15_RS06110	COG0824	Thioesterase
PCI15_RS06110	COG1250	3-hydroxyacyl-CoA dehydrogenase
PCI15_RS06115	COG3246	L-lysine catabolic process to acetate
PCI15_RS06125	COG2194	sulfuric ester hydrolase activity
PCI15_RS06130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PCI15_RS06135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PCI15_RS06145	COG3962	Belongs to the TPP enzyme family
PCI15_RS06150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PCI15_RS06155	COG0673	inositol 2-dehydrogenase activity
PCI15_RS06180	COG0673	inositol 2-dehydrogenase activity
PCI15_RS06185	COG3718	enzyme involved in inositol metabolism
PCI15_RS06200	COG0175	sulfate reduction
PCI15_RS06205	COG0730	response to heat
PCI15_RS06210	COG0175	sulfate reduction
PCI15_RS06215	COG2962	Rard protein
PCI15_RS06220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PCI15_RS06230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PCI15_RS06240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PCI15_RS06250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PCI15_RS06260	COG0205	6-phosphofructokinase activity
PCI15_RS06295	COG0004	ammonium transporteR
PCI15_RS06300	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PCI15_RS06305	COG3148	PFAM DTW domain containing protein
PCI15_RS06325	COG0277	FAD linked oxidase domain protein
PCI15_RS06340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PCI15_RS06345	COG2186	Transcriptional regulator
PCI15_RS06355	COG0508	dehydrogenase complex catalyzes the overall conversion of
PCI15_RS06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PCI15_RS06370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PCI15_RS06375	COG0166	Belongs to the GPI family
PCI15_RS06380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PCI15_RS06390	COG0521	Mo-molybdopterin cofactor biosynthetic process
PCI15_RS06405	COG0746	molybdenum cofactor guanylyltransferase activity
PCI15_RS06410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PCI15_RS06415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PCI15_RS06420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PCI15_RS06425	COG0723	plastoquinol--plastocyanin reductase activity
PCI15_RS06430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PCI15_RS06435	COG2857	Cytochrome c1
PCI15_RS06440	COG0625	glutathione transferase activity
PCI15_RS06445	COG2969	positive regulation of protein catabolic process
PCI15_RS06450	COG2823	Periplasmic or secreted lipoprotein
PCI15_RS06455	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PCI15_RS06460	COG0792	nuclease activity
PCI15_RS06465	COG3107	peptidoglycan biosynthetic process
PCI15_RS06485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PCI15_RS06490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PCI15_RS06495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PCI15_RS06510	COG2983	Belongs to the UPF0260 family
PCI15_RS06515	COG0737	Belongs to the 5'-nucleotidase family
PCI15_RS06530	COG2001	Belongs to the MraZ family
PCI15_RS06535	COG0275	rRNA processing
PCI15_RS06550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PCI15_RS06555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PCI15_RS06560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PCI15_RS06565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PCI15_RS06570	COG0772	Belongs to the SEDS family
PCI15_RS06575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PCI15_RS06580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PCI15_RS06585	COG1181	Belongs to the D-alanine--D-alanine ligase family
PCI15_RS06605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PCI15_RS06610	COG0653	protein targeting
PCI15_RS06615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PCI15_RS06620	COG0352	thiamine-phosphate diphosphorylase activity
PCI15_RS06625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PCI15_RS06630	COG0237	dephospho-CoA kinase activity
PCI15_RS06635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PCI15_RS06650	COG4969	Belongs to the N-Me-Phe pilin family
PCI15_RS06655	COG4969	Belongs to the N-Me-Phe pilin family
PCI15_RS06670	COG3023	N-Acetylmuramoyl-L-alanine amidase
PCI15_RS06675	COG3842	ATPase activity
PCI15_RS06680	COG1178	ABC-type Fe3 transport system permease component
PCI15_RS06685	COG1840	ABC-type Fe3 transport system, periplasmic component
PCI15_RS06705	COG0534	Mate efflux family protein
PCI15_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS06720	COG3012	SEC-C Motif Domain Protein
PCI15_RS06725	COG2925	Exonuclease
PCI15_RS06755	COG3022	response to hydroperoxide
PCI15_RS06770	COG0180	Tryptophanyl-tRNA synthetase
PCI15_RS06780	COG2837	iron assimilation
PCI15_RS06785	COG2199	diguanylate cyclase activity
PCI15_RS06785	COG2203	Gaf domain
PCI15_RS06790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PCI15_RS06810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PCI15_RS06815	COG0748	coenzyme F420 binding
PCI15_RS06845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PCI15_RS06850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PCI15_RS06855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PCI15_RS06860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PCI15_RS06865	COG4660	Part of a membrane complex involved in electron transport
PCI15_RS06870	COG4659	FMN binding
PCI15_RS06875	COG4658	electron transport chain
PCI15_RS06885	COG2878	Part of a membrane complex involved in electron transport
PCI15_RS06890	COG4657	Part of a membrane complex involved in electron transport
PCI15_RS06895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PCI15_RS06905	COG1648	precorrin-2 dehydrogenase activity
PCI15_RS06905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PCI15_RS06910	COG2267	carboxylic ester hydrolase activity
PCI15_RS06915	COG2827	Endonuclease containing a URI domain
PCI15_RS06925	COG0348	domain, Protein
PCI15_RS06930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS06935	COG0418	dihydroorotase activity
PCI15_RS06940	COG0252	asparaginase activity
PCI15_RS06965	COG1136	(ABC) transporter
PCI15_RS06980	COG1686	Belongs to the peptidase S11 family
PCI15_RS06990	COG0436	Aminotransferase
PCI15_RS07015	COG1643	Atp-dependent helicase
PCI15_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS07030	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS07055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS07070	COG0697	spore germination
PCI15_RS07075	COG0420	3'-5' exonuclease activity
PCI15_RS07080	COG0419	ATPase involved in DNA repair
PCI15_RS07115	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PCI15_RS07150	COG0714	Associated with various cellular activities
PCI15_RS07165	COG2304	oxidoreductase activity
PCI15_RS07170	COG2304	oxidoreductase activity
PCI15_RS07180	COG0778	Nitroreductase
PCI15_RS07190	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS07195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PCI15_RS07200	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS07220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PCI15_RS07235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PCI15_RS07240	COG0174	glutamine synthetase
PCI15_RS07245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS07250	COG3226	Transcriptional regulator
PCI15_RS07265	COG3706	GGDEF domain
PCI15_RS07270	COG2132	Multicopper oxidase
PCI15_RS07295	COG0778	Nitroreductase
PCI15_RS07300	COG0697	spore germination
PCI15_RS07320	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS07325	COG1741	Belongs to the pirin family
PCI15_RS07330	COG0583	DNA-binding transcription factor activity
PCI15_RS07335	COG0435	Glutathione S-transferase
PCI15_RS07360	COG3226	Transcriptional regulator
PCI15_RS07395	COG0346	lactoylglutathione lyase activity
PCI15_RS07410	COG1984	allophanate hydrolase subunit 2
PCI15_RS07415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PCI15_RS07420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PCI15_RS07425	COG4336	lyase activity
PCI15_RS07450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PCI15_RS07455	COG3383	formate dehydrogenase (NAD+) activity
PCI15_RS07485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PCI15_RS07505	COG0174	glutamine synthetase
PCI15_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS07560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS07565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PCI15_RS07570	COG1115	amino acid carrier protein
PCI15_RS07595	COG0583	DNA-binding transcription factor activity
PCI15_RS07600	COG1054	Belongs to the UPF0176 family
PCI15_RS07605	COG3706	GGDEF domain
PCI15_RS07605	COG2203	Gaf domain
PCI15_RS07605	COG5001	Diguanylate cyclase
PCI15_RS07605	COG4251	negative regulation of phosphorylation
PCI15_RS07630	COG0583	DNA-binding transcription factor activity
PCI15_RS07720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PCI15_RS07730	COG1228	amidohydrolase
PCI15_RS07735	COG0523	cobalamin synthesis protein
PCI15_RS07765	COG4774	siderophore transport
PCI15_RS07765	COG1629	transport
PCI15_RS07800	COG5001	Diguanylate cyclase
PCI15_RS07805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PCI15_RS07810	COG2329	Antibiotic biosynthesis monooxygenase
PCI15_RS07820	COG0640	Transcriptional regulator
PCI15_RS07825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PCI15_RS07825	COG2755	lipolytic protein G-D-S-L family
PCI15_RS07830	COG0640	Transcriptional regulator
PCI15_RS07850	COG0010	Belongs to the arginase family
PCI15_RS07865	COG1166	arginine decarboxylase activity
PCI15_RS07885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS07890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS07895	COG0686	Belongs to the AlaDH PNT family
PCI15_RS07905	COG0280	phosphate acetyltransferase
PCI15_RS07915	COG2197	response regulator
PCI15_RS07925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PCI15_RS08140	COG1598	PFAM Uncharacterised protein family UPF0150
PCI15_RS08145	COG1724	mRNA binding
PCI15_RS08165	COG2261	transglycosylase associated protein
PCI15_RS08185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PCI15_RS08195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PCI15_RS08195	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
PCI15_RS08205	COG0584	glycerophosphoryl diester phosphodiesterase
PCI15_RS08275	COG0159	tryptophan synthase activity
PCI15_RS08285	COG1309	transcriptional regulator
PCI15_RS08295	COG1902	pentaerythritol trinitrate reductase activity
PCI15_RS08295	COG0446	pyridine nucleotide-disulphide oxidoreductase
PCI15_RS08300	COG0006	proline dipeptidase activity
PCI15_RS08310	COG2274	protein secretion by the type I secretion system
PCI15_RS08325	COG0037	tRNA processing
PCI15_RS08355	COG3258	Cytochrome c
PCI15_RS08365	COG0737	Belongs to the 5'-nucleotidase family
PCI15_RS08375	COG3101	peptidyl-lysine hydroxylation
PCI15_RS08400	COG0023	Translation Initiation Factor
PCI15_RS08415	COG3794	PFAM blue (type 1) copper domain protein
PCI15_RS08430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PCI15_RS08435	COG2954	triphosphatase activity
PCI15_RS08440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PCI15_RS08440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PCI15_RS08445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PCI15_RS08470	COG0671	phosphoesterase, PA-phosphatase related
PCI15_RS08475	COG2974	May be involved in recombination
PCI15_RS08485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PCI15_RS08490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PCI15_RS08525	COG2010	Cytochrome c
PCI15_RS08540	COG3278	Belongs to the heme-copper respiratory oxidase family
PCI15_RS08550	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PCI15_RS08560	COG0425	Belongs to the sulfur carrier protein TusA family
PCI15_RS08570	COG2199	diguanylate cyclase activity
PCI15_RS08570	COG3287	FIST C domain
PCI15_RS08570	COG2200	EAL domain
PCI15_RS08590	COG3243	poly(R)-hydroxyalkanoic acid synthase
PCI15_RS08600	COG0084	hydrolase, TatD family'
PCI15_RS08605	COG0741	lytic transglycosylase activity
PCI15_RS08610	COG0488	(ABC) transporter
PCI15_RS08615	COG0589	response to stress
PCI15_RS08655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PCI15_RS08660	COG1199	ATP-dependent helicase activity
PCI15_RS08675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PCI15_RS08700	COG0302	gtp cyclohydrolase
PCI15_RS08715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PCI15_RS08720	COG2814	Major facilitator Superfamily
PCI15_RS08730	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
PCI15_RS08740	COG0741	lytic transglycosylase activity
PCI15_RS08740	COG1388	LysM domain
PCI15_RS08745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PCI15_RS08750	COG1858	cytochrome C peroxidase
PCI15_RS08765	COG4191	Histidine kinase
PCI15_RS08765	COG0784	Response regulator, receiver
PCI15_RS08770	COG2204	response regulator
PCI15_RS08775	COG0745	RESPONSE REGULATOR receiver
PCI15_RS08780	COG2226	methyltransferase
PCI15_RS08785	COG0328	RNA-DNA hybrid ribonuclease activity
PCI15_RS08790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PCI15_RS08800	COG2816	NAD+ diphosphatase activity
PCI15_RS08810	COG0616	signal peptide processing
PCI15_RS08825	COG1472	Belongs to the glycosyl hydrolase 3 family
PCI15_RS08830	COG0668	transmembrane transport
PCI15_RS08845	COG2207	Transcriptional regulator
PCI15_RS08860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PCI15_RS08890	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PCI15_RS08900	COG1477	protein flavinylation
PCI15_RS08910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PCI15_RS08935	COG1136	(ABC) transporter
PCI15_RS08950	COG0658	competence protein
PCI15_RS08950	COG2333	competence protein COMEC
PCI15_RS08955	COG0811	peptide transport
PCI15_RS08960	COG0848	biopolymer transport protein
PCI15_RS08965	COG1663	tetraacyldisaccharide 4'-kinase activity
PCI15_RS08970	COG2835	tetraacyldisaccharide 4'-kinase activity
PCI15_RS08975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PCI15_RS08980	COG3813	Protein conserved in bacteria
PCI15_RS08985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PCI15_RS08990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PCI15_RS08995	COG1530	ribonuclease E activity
PCI15_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS09020	COG1607	acyl-coa hydrolase
PCI15_RS09030	COG0596	Alpha beta hydrolase
PCI15_RS09035	COG1802	Transcriptional regulator
PCI15_RS09040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PCI15_RS09045	COG0372	Belongs to the citrate synthase family
PCI15_RS09060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PCI15_RS09080	COG3243	poly(R)-hydroxyalkanoic acid synthase
PCI15_RS09095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PCI15_RS09100	COG0066	3-isopropylmalate dehydratase activity
PCI15_RS09105	COG0473	3-isopropylmalate dehydrogenase activity
PCI15_RS09110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PCI15_RS09120	COG1522	sequence-specific DNA binding
PCI15_RS09130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PCI15_RS09135	COG0506	proline dehydrogenase activity
PCI15_RS09135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PCI15_RS09135	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PCI15_RS09145	COG1802	Transcriptional regulator
PCI15_RS09155	COG0579	oxidoreductase
PCI15_RS09185	COG0513	Belongs to the DEAD box helicase family
PCI15_RS09205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PCI15_RS09210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PCI15_RS09220	COG0628	permease
PCI15_RS09235	COG0564	pseudouridine synthase activity
PCI15_RS09245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PCI15_RS09255	COG0583	DNA-binding transcription factor activity
PCI15_RS09265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PCI15_RS09280	COG1393	Belongs to the ArsC family
PCI15_RS09285	COG1295	ribonuclease BN
PCI15_RS09285	COG1959	2 iron, 2 sulfur cluster binding
PCI15_RS09295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PCI15_RS09310	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PCI15_RS09320	COG1079	Belongs to the binding-protein-dependent transport system permease family
PCI15_RS09325	COG4603	Belongs to the binding-protein-dependent transport system permease family
PCI15_RS09330	COG3845	ABC transporter
PCI15_RS09340	COG2329	Antibiotic biosynthesis monooxygenase
PCI15_RS09345	COG0442	prolyl-tRNA aminoacylation
PCI15_RS09365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PCI15_RS09380	COG4566	intracellular signal transduction
PCI15_RS09385	COG4191	Histidine kinase
PCI15_RS09390	COG0318	PFAM AMP-dependent synthetase and ligase
PCI15_RS09400	COG4783	chaperone-mediated protein folding
PCI15_RS09405	COG0425	Belongs to the sulfur carrier protein TusA family
PCI15_RS09420	COG0583	DNA-binding transcription factor activity
PCI15_RS09425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PCI15_RS09435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PCI15_RS09450	COG0564	pseudouridine synthase activity
PCI15_RS09455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PCI15_RS09460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PCI15_RS09465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PCI15_RS09470	COG4651	solute:proton antiporter activity
PCI15_RS09470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PCI15_RS09475	COG0316	Belongs to the HesB IscA family
PCI15_RS09475	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PCI15_RS09480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PCI15_RS09495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PCI15_RS09510	COG1049	propionate catabolic process, 2-methylcitrate cycle
PCI15_RS09515	COG0217	transcriptional regulatory protein
PCI15_RS09525	COG1794	racemase activity, acting on amino acids and derivatives
PCI15_RS09540	COG2081	HI0933 family
PCI15_RS09575	COG0583	DNA-binding transcription factor activity
PCI15_RS09600	COG1006	Multisubunit Na H antiporter MnhC subunit
PCI15_RS09605	COG0651	ATP synthesis coupled electron transport
PCI15_RS09610	COG0651	ATP synthesis coupled electron transport
PCI15_RS09620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PCI15_RS09620	COG2111	Na H antiporter
PCI15_RS09635	COG0583	DNA-binding transcription factor activity
PCI15_RS09640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PCI15_RS09655	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS09670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS09675	COG1757	Na H antiporter
PCI15_RS09680	COG2423	ornithine cyclodeaminase activity
PCI15_RS09715	COG0583	DNA-binding transcription factor activity
PCI15_RS09735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PCI15_RS09740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PCI15_RS09745	COG2116	formate transmembrane transporter activity
PCI15_RS09755	COG5001	Diguanylate cyclase
PCI15_RS09755	COG4251	negative regulation of phosphorylation
PCI15_RS09755	COG3706	GGDEF domain
PCI15_RS09755	COG2203	Gaf domain
PCI15_RS09760	COG0583	DNA-binding transcription factor activity
PCI15_RS09770	COG2423	ornithine cyclodeaminase activity
PCI15_RS09785	COG1944	ATP diphosphatase activity
PCI15_RS09790	COG0583	DNA-binding transcription factor activity
PCI15_RS09830	COG0583	DNA-binding transcription factor activity
PCI15_RS09835	COG0443	Heat shock 70 kDa protein
PCI15_RS09840	COG0826	peptidase U32
PCI15_RS09845	COG0826	peptidase U32
PCI15_RS09850	COG3154	lipid carrier protein
PCI15_RS09890	COG2353	YceI-like domain
PCI15_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS09920	COG0583	DNA-binding transcription factor activity
PCI15_RS09930	COG0174	glutamine synthetase
PCI15_RS09935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS09945	COG0667	Aldo Keto reductase
PCI15_RS09950	COG2207	Transcriptional regulator
PCI15_RS09985	COG2204	response regulator
PCI15_RS10015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PCI15_RS10025	COG0438	transferase activity, transferring glycosyl groups
PCI15_RS10055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PCI15_RS10090	COG3300	MHYT domain
PCI15_RS10090	COG5001	Diguanylate cyclase
PCI15_RS10105	COG4191	Histidine kinase
PCI15_RS10110	COG1733	regulation of RNA biosynthetic process
PCI15_RS10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PCI15_RS10180	COG2113	Glycine betaine
PCI15_RS10185	COG4176	ABC-type proline glycine betaine transport system permease component
PCI15_RS10190	COG4175	Glycine betaine
PCI15_RS10195	COG0697	spore germination
PCI15_RS10205	COG0583	DNA-binding transcription factor activity
PCI15_RS10210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PCI15_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS10225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PCI15_RS10225	COG1017	nitric oxide dioxygenase activity
PCI15_RS10230	COG0583	DNA-binding transcription factor activity
PCI15_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS10265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PCI15_RS10270	COG4115	mRNA cleavage
PCI15_RS10275	COG2161	toxin-antitoxin pair type II binding
PCI15_RS10280	COG2197	response regulator
PCI15_RS10350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PCI15_RS10360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PCI15_RS10370	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS10375	COG0679	Auxin Efflux Carrier
PCI15_RS10385	COG3971	2-oxopent-4-enoate hydratase activity
PCI15_RS10395	COG0179	Fumarylacetoacetate (FAA) hydrolase
PCI15_RS10440	COG2814	Major facilitator Superfamily
PCI15_RS10450	COG3384	dioxygenase
PCI15_RS10460	COG3384	dioxygenase
PCI15_RS10465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PCI15_RS10480	COG0175	sulfate reduction
PCI15_RS10485	COG1218	3'(2'),5'-bisphosphate nucleotidase
PCI15_RS10490	COG0583	DNA-binding transcription factor activity
PCI15_RS10495	COG4638	Rieske (2fe-2S)
PCI15_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS10505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PCI15_RS10535	COG3300	MHYT domain
PCI15_RS10535	COG5001	Diguanylate cyclase
PCI15_RS10550	COG3833	ABC-type maltose transport systems, permease component
PCI15_RS10555	COG3842	ATPase activity
PCI15_RS10560	COG0584	glycerophosphoryl diester phosphodiesterase
PCI15_RS10565	COG1609	Transcriptional regulator
PCI15_RS10575	COG0842	Transport permease protein
PCI15_RS10580	COG1131	(ABC) transporter
PCI15_RS10585	COG0625	glutathione transferase activity
PCI15_RS10595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS10595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS10605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS10625	COG0318	PFAM AMP-dependent synthetase and ligase
PCI15_RS10630	COG1802	Transcriptional regulator
PCI15_RS10635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS10650	COG1802	Transcriptional regulator
PCI15_RS10660	COG4106	trans-aconitate 2-methyltransferase activity
PCI15_RS10680	COG0583	DNA-binding transcription factor activity
PCI15_RS10690	COG0653	protein targeting
PCI15_RS10720	COG0765	amino acid transport
PCI15_RS10725	COG0765	amino acid transport
PCI15_RS10755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PCI15_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS10790	COG1473	amidohydrolase
PCI15_RS10795	COG0583	DNA-binding transcription factor activity
PCI15_RS10800	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS10805	COG2161	toxin-antitoxin pair type II binding
PCI15_RS10815	COG2258	MOSC domain
PCI15_RS10860	COG1017	nitric oxide dioxygenase activity
PCI15_RS10860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PCI15_RS10870	COG3604	Transcriptional regulator
PCI15_RS10885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PCI15_RS10895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS10930	COG1132	(ABC) transporter
PCI15_RS10935	COG2945	thiolester hydrolase activity
PCI15_RS10940	COG3634	alkyl hydroperoxide reductase activity
PCI15_RS10950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PCI15_RS10975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS10990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS11000	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS11010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS11010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PCI15_RS11030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PCI15_RS11035	COG0583	DNA-binding transcription factor activity
PCI15_RS11055	COG3119	arylsulfatase activity
PCI15_RS11060	COG0583	DNA-binding transcription factor activity
PCI15_RS11065	COG1027	Aspartate ammonia-lyase
PCI15_RS11070	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS11075	COG0697	spore germination
PCI15_RS11085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PCI15_RS11090	COG0583	DNA-binding transcription factor activity
PCI15_RS11110	COG2226	methyltransferase
PCI15_RS11115	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS11120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS11135	COG2175	clavaminate synthase activity
PCI15_RS11145	COG1309	transcriptional regulator
PCI15_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS11185	COG2119	membrane
PCI15_RS11205	COG1176	ABC-type spermidine putrescine transport system, permease component I
PCI15_RS11210	COG3842	ATPase activity
PCI15_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS11255	COG1294	oxidase, subunit
PCI15_RS11260	COG1271	oxidase subunit
PCI15_RS11315	COG0583	DNA-binding transcription factor activity
PCI15_RS11320	COG0564	pseudouridine synthase activity
PCI15_RS11335	COG1566	PFAM secretion protein HlyD family protein
PCI15_RS11360	COG2850	peptidyl-arginine hydroxylation
PCI15_RS11365	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PCI15_RS11380	COG1461	Dihydroxyacetone kinase
PCI15_RS11385	COG2376	Dihydroxyacetone kinase
PCI15_RS11390	COG0698	ribose 5-phosphate isomerase
PCI15_RS11400	COG1129	ABC transporter
PCI15_RS11405	COG1172	Belongs to the binding-protein-dependent transport system permease family
PCI15_RS11415	COG1063	alcohol dehydrogenase
PCI15_RS11420	COG0840	transmembrane signaling receptor activity
PCI15_RS11425	COG1858	cytochrome C peroxidase
PCI15_RS11440	COG4232	protein-disulfide reductase activity
PCI15_RS11445	COG0583	DNA-binding transcription factor activity
PCI15_RS11485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS11505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PCI15_RS11510	COG0583	DNA-binding transcription factor activity
PCI15_RS11515	COG0840	transmembrane signaling receptor activity
PCI15_RS11535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PCI15_RS11555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PCI15_RS11565	COG2814	Major facilitator Superfamily
PCI15_RS11570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PCI15_RS11580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PCI15_RS11585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PCI15_RS11590	COG2135	peptidase activity
PCI15_RS11600	COG1451	nucleotide metabolic process
PCI15_RS11605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS11630	COG3045	CreA protein
PCI15_RS11640	COG0583	DNA-binding transcription factor activity
PCI15_RS11655	COG4772	TonB-dependent receptor
PCI15_RS11660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PCI15_RS11665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS11670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS11675	COG1120	ATPase activity
PCI15_RS11685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PCI15_RS11690	COG2873	o-acetylhomoserine
PCI15_RS11695	COG0596	Alpha beta hydrolase
PCI15_RS11700	COG1024	Enoyl-CoA hydratase
PCI15_RS11700	COG1250	3-hydroxyacyl-CoA dehydrogenase
PCI15_RS11715	COG1902	pentaerythritol trinitrate reductase activity
PCI15_RS11720	COG0583	DNA-binding transcription factor activity
PCI15_RS11725	COG1858	cytochrome C peroxidase
PCI15_RS11735	COG0436	Aminotransferase
PCI15_RS11745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS11755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PCI15_RS11760	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS11765	COG3604	Transcriptional regulator
PCI15_RS11780	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS11785	COG0006	proline dipeptidase activity
PCI15_RS11790	COG0583	DNA-binding transcription factor activity
PCI15_RS11830	COG2207	Transcriptional regulator
PCI15_RS11830	COG3708	Transcriptional regulator
PCI15_RS11845	COG0583	DNA-binding transcription factor activity
PCI15_RS11850	COG0604	alcohol dehydrogenase
PCI15_RS11855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PCI15_RS11860	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PCI15_RS11895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PCI15_RS11900	COG1459	type II secretion system
PCI15_RS11925	COG3156	type II secretion system protein K
PCI15_RS11945	COG1450	Type ii and iii secretion system protein
PCI15_RS11970	COG2204	response regulator
PCI15_RS11975	COG3409	Peptidoglycan-binding domain 1 protein
PCI15_RS11975	COG3267	Type II secretory pathway component ExeA
PCI15_RS12010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PCI15_RS12020	COG1178	ABC-type Fe3 transport system permease component
PCI15_RS12025	COG4143	(ABC) transporter
PCI15_RS12120	COG0616	signal peptide processing
PCI15_RS12130	COG4626	Terminase
PCI15_RS12130	COG1802	Transcriptional regulator
PCI15_RS12170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PCI15_RS12175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PCI15_RS12275	COG0629	single-stranded DNA binding
PCI15_RS12335	COG0322	excinuclease ABC activity
PCI15_RS12355	COG2084	Dehydrogenase
PCI15_RS12360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PCI15_RS12365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PCI15_RS12375	COG0564	pseudouridine synthase activity
PCI15_RS12380	COG0670	Belongs to the BI1 family
PCI15_RS12385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PCI15_RS12400	COG2920	part of a sulfur-relay system
PCI15_RS12405	COG2084	Dehydrogenase
PCI15_RS12410	COG3622	Belongs to the hyi family
PCI15_RS12415	COG0835	chemotaxis
PCI15_RS12420	COG0840	transmembrane signaling receptor activity
PCI15_RS12425	COG0432	Pfam Uncharacterised protein family UPF0047
PCI15_RS12430	COG0697	spore germination
PCI15_RS12435	COG0583	DNA-binding transcription factor activity
PCI15_RS12440	COG0084	hydrolase, TatD family'
PCI15_RS12455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PCI15_RS12460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PCI15_RS12470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PCI15_RS12475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PCI15_RS12490	COG0416	fatty acid biosynthetic process
PCI15_RS12495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PCI15_RS12500	COG1399	metal-binding, possibly nucleic acid-binding protein
PCI15_RS12505	COG0424	maF-like protein
PCI15_RS12520	COG0546	phosphoglycolate phosphatase activity
PCI15_RS12525	COG1959	2 iron, 2 sulfur cluster binding
PCI15_RS12530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PCI15_RS12545	COG0277	FAD linked oxidase domain protein
PCI15_RS12545	COG0247	lactate metabolic process
PCI15_RS12550	COG0583	DNA-binding transcription factor activity
PCI15_RS12560	COG0697	spore germination
PCI15_RS12575	COG4628	conserved protein (DUF2132)
PCI15_RS12615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PCI15_RS12625	COG0300	oxidoreductase activity
PCI15_RS12635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PCI15_RS12640	COG1410	methionine synthase
PCI15_RS12640	COG0646	methionine synthase
PCI15_RS12645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PCI15_RS12655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PCI15_RS12675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PCI15_RS12680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PCI15_RS12685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PCI15_RS12690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PCI15_RS12710	COG0492	ferredoxin-NADP+ reductase activity
PCI15_RS12715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PCI15_RS12720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PCI15_RS12725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PCI15_RS12730	COG0542	response to heat
PCI15_RS12735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PCI15_RS12740	COG1278	Cold shock
PCI15_RS12750	COG1187	pseudouridine synthase activity
PCI15_RS12765	COG0482	sulfurtransferase activity
PCI15_RS12770	COG2915	High frequency lysogenization protein hflD homolog
PCI15_RS12785	COG4251	negative regulation of phosphorylation
PCI15_RS12785	COG3706	GGDEF domain
PCI15_RS12785	COG2203	Gaf domain
PCI15_RS12785	COG5001	Diguanylate cyclase
PCI15_RS12795	COG1252	NADH dehydrogenase
PCI15_RS12805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PCI15_RS12810	COG0740	serine-type endopeptidase activity
PCI15_RS12815	COG0544	peptidyl-prolyl cis-trans isomerase activity
PCI15_RS12840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PCI15_RS12870	COG0215	cysteine-tRNA ligase activity
PCI15_RS12875	COG1528	Iron-storage protein
PCI15_RS12880	COG1607	acyl-coa hydrolase
PCI15_RS12885	COG0778	Nitroreductase
PCI15_RS12890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PCI15_RS12895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PCI15_RS12900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PCI15_RS12910	COG2832	Protein of unknown function (DUF454)
PCI15_RS12925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PCI15_RS12935	COG1286	toxin biosynthetic process
PCI15_RS12945	COG0285	dihydrofolate synthase activity
PCI15_RS12955	COG0159	tryptophan synthase activity
PCI15_RS12965	COG0135	phosphoribosylanthranilate isomerase activity
PCI15_RS12985	COG4977	sequence-specific DNA binding
PCI15_RS12990	COG2175	clavaminate synthase activity
PCI15_RS12995	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PCI15_RS13000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PCI15_RS13000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PCI15_RS13005	COG3639	organic phosphonate transmembrane transporter activity
PCI15_RS13045	COG0513	Belongs to the DEAD box helicase family
PCI15_RS13090	COG1840	ABC-type Fe3 transport system, periplasmic component
PCI15_RS13105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PCI15_RS13110	COG0010	Belongs to the arginase family
PCI15_RS13145	COG3138	arginine N-succinyltransferase
PCI15_RS13160	COG3724	N-succinylarginine dihydrolase activity
PCI15_RS13165	COG0384	phenazine biosynthesis protein PhzF
PCI15_RS13175	COG2197	response regulator
PCI15_RS13210	COG1522	sequence-specific DNA binding
PCI15_RS13215	COG0019	diaminopimelate decarboxylase activity
PCI15_RS13225	COG0583	DNA-binding transcription factor activity
PCI15_RS13235	COG0583	DNA-binding transcription factor activity
PCI15_RS13240	COG0668	transmembrane transport
PCI15_RS13270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PCI15_RS13275	COG4638	Rieske (2fe-2S)
PCI15_RS13285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS13285	COG4191	Histidine kinase
PCI15_RS13290	COG3437	response regulator, receiver
PCI15_RS13290	COG0784	Response regulator, receiver
PCI15_RS13295	COG2072	flavoprotein involved in K transport
PCI15_RS13310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PCI15_RS13315	COG1113	amino acid transport
PCI15_RS13330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS13345	COG0351	phosphomethylpyrimidine kinase
PCI15_RS13350	COG1116	anion transmembrane transporter activity
PCI15_RS13355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PCI15_RS13360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PCI15_RS13365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PCI15_RS13375	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
PCI15_RS13385	COG0346	lactoylglutathione lyase activity
PCI15_RS13410	COG0596	Alpha beta hydrolase
PCI15_RS13420	COG1177	transmembrane transport
PCI15_RS13425	COG1176	ABC-type spermidine putrescine transport system, permease component I
PCI15_RS13435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PCI15_RS13440	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS13450	COG3835	regulator
PCI15_RS13490	COG2003	Belongs to the UPF0758 family
PCI15_RS13615	COG5001	Diguanylate cyclase
PCI15_RS13615	COG3300	MHYT domain
PCI15_RS13750	COG3437	response regulator, receiver
PCI15_RS13755	COG4191	Histidine kinase
PCI15_RS13765	COG2204	response regulator
PCI15_RS13770	COG0556	nucleotide-excision repair
PCI15_RS13775	COG0436	Aminotransferase
PCI15_RS13780	COG2989	Protein conserved in bacteria
PCI15_RS13795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PCI15_RS13805	COG0697	spore germination
PCI15_RS13810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PCI15_RS13815	COG0326	Molecular chaperone. Has ATPase activity
PCI15_RS13825	COG2353	YceI-like domain
PCI15_RS13830	COG3038	cytochrome b561
PCI15_RS13865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PCI15_RS13870	COG1074	ATP-dependent DNA helicase activity
PCI15_RS13875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PCI15_RS13895	COG0668	transmembrane transport
PCI15_RS13900	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS13905	COG2030	dehydratase
PCI15_RS13915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PCI15_RS13920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PCI15_RS13925	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PCI15_RS13930	COG2885	chlorophyll binding
PCI15_RS13935	COG0823	Involved in the tonB-independent uptake of proteins
PCI15_RS13960	COG2255	four-way junction helicase activity
PCI15_RS13965	COG0632	four-way junction helicase activity
PCI15_RS13975	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PCI15_RS13980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PCI15_RS14000	COG0045	succinate-CoA ligase (ADP-forming) activity
PCI15_RS14020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PCI15_RS14030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PCI15_RS14050	COG3130	regulation of translation
PCI15_RS14055	COG0167	dihydroorotate dehydrogenase activity
PCI15_RS14070	COG1090	epimerase
PCI15_RS14075	COG0307	riboflavin synthase, alpha
PCI15_RS14085	COG0579	oxidoreductase
PCI15_RS14100	COG1739	Uncharacterized protein family UPF0029
PCI15_RS14105	COG3706	GGDEF domain
PCI15_RS14115	COG0708	Exodeoxyribonuclease III
PCI15_RS14120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PCI15_RS14130	COG3448	diguanylate cyclase activity
PCI15_RS14130	COG4175	Glycine betaine
PCI15_RS14135	COG4176	ABC-type proline glycine betaine transport system permease component
PCI15_RS14145	COG0589	response to stress
PCI15_RS14155	COG2193	ferroxidase activity
PCI15_RS14170	COG2906	2 iron, 2 sulfur cluster binding
PCI15_RS14190	COG0640	Transcriptional regulator
PCI15_RS14195	COG1042	CoA-binding domain protein
PCI15_RS14195	COG0045	succinate-CoA ligase (ADP-forming) activity
PCI15_RS14195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PCI15_RS14215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PCI15_RS14225	COG0133	tryptophan synthase activity
PCI15_RS14245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PCI15_RS14255	COG0745	RESPONSE REGULATOR receiver
PCI15_RS14265	COG3038	cytochrome b561
PCI15_RS14285	COG3706	GGDEF domain
PCI15_RS14290	COG5001	Diguanylate cyclase
PCI15_RS14315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PCI15_RS14320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PCI15_RS14325	COG3616	Alanine racemase, N-terminal domain
PCI15_RS14330	COG2423	ornithine cyclodeaminase activity
PCI15_RS14335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PCI15_RS14365	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS14380	COG2304	oxidoreductase activity
PCI15_RS14395	COG0714	Associated with various cellular activities
PCI15_RS14410	COG2205	protein histidine kinase activity
PCI15_RS14420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PCI15_RS14430	COG1469	GTP cyclohydrolase I activity
PCI15_RS14435	COG0583	DNA-binding transcription factor activity
PCI15_RS14445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PCI15_RS14465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PCI15_RS14485	COG3706	GGDEF domain
PCI15_RS14495	COG1522	sequence-specific DNA binding
PCI15_RS14510	COG0308	aminopeptidase N
PCI15_RS14520	COG3139	Protein of unknown function (DUF1315)
PCI15_RS14525	COG0705	Rhomboid family
PCI15_RS14530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PCI15_RS14535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PCI15_RS14540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PCI15_RS14545	COG3706	GGDEF domain
PCI15_RS14615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PCI15_RS14620	COG0436	Aminotransferase
PCI15_RS14630	COG1639	'signal transduction protein
PCI15_RS14640	COG0501	Belongs to the peptidase M48B family
PCI15_RS14680	COG0513	Belongs to the DEAD box helicase family
PCI15_RS14690	COG2095	MarC family integral membrane protein
PCI15_RS14700	COG0791	NLP P60 protein
PCI15_RS14715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PCI15_RS14720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PCI15_RS14735	COG3081	Nucleoid-associated protein
PCI15_RS14755	COG0717	Belongs to the dCTP deaminase family
PCI15_RS14760	COG0489	protein tyrosine kinase activity
PCI15_RS14780	COG1234	tRNA 3'-trailer cleavage
PCI15_RS14785	COG0450	alkyl hydroperoxide reductase
PCI15_RS14795	COG1598	PFAM Uncharacterised protein family UPF0150
PCI15_RS14800	COG2824	Alkylphosphonate utilization operon protein PhnA
PCI15_RS14810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS14820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS14830	COG3958	Transketolase
PCI15_RS14835	COG3959	Transketolase, thiamine diphosphate binding domain
PCI15_RS14840	COG1609	Transcriptional regulator
PCI15_RS14860	COG1492	cobalamin metabolic process
PCI15_RS14910	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PCI15_RS14915	COG1797	cobyrinic acid a,c-diamide synthase activity
PCI15_RS14950	COG0310	cobalt ion transport
PCI15_RS14960	COG0840	transmembrane signaling receptor activity
PCI15_RS14965	COG0602	queuosine metabolic process
PCI15_RS14970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PCI15_RS14975	COG3706	GGDEF domain
PCI15_RS14985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS14990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PCI15_RS15005	COG0189	ligase activity
PCI15_RS15005	COG4067	protein conserved in archaea
PCI15_RS15015	COG0330	HflC and HflK could
PCI15_RS15030	COG1309	transcriptional regulator
PCI15_RS15035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PCI15_RS15040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PCI15_RS15045	COG1538	Outer membrane efflux protein
PCI15_RS15050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PCI15_RS15070	COG0583	DNA-binding transcription factor activity
PCI15_RS15075	COG0840	transmembrane signaling receptor activity
PCI15_RS15080	COG0840	transmembrane signaling receptor activity
PCI15_RS15090	COG4120	Belongs to the binding-protein-dependent transport system permease family
PCI15_RS15095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PCI15_RS15100	COG1609	Transcriptional regulator
PCI15_RS15100	COG2207	Transcriptional regulator
PCI15_RS15135	COG1917	Cupin 2, conserved barrel domain protein
PCI15_RS15135	COG2207	Transcriptional regulator
PCI15_RS15145	COG3486	L-lysine 6-monooxygenase (NADPH) activity
PCI15_RS15150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PCI15_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS15195	COG1024	Enoyl-CoA hydratase
PCI15_RS15200	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS15215	COG2203	Gaf domain
PCI15_RS15215	COG3706	GGDEF domain
PCI15_RS15215	COG5001	Diguanylate cyclase
PCI15_RS15215	COG4251	negative regulation of phosphorylation
PCI15_RS15220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PCI15_RS15235	COG0596	Alpha beta hydrolase
PCI15_RS15280	COG0789	Transcriptional regulator
PCI15_RS15285	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS15290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PCI15_RS15295	COG1024	Enoyl-CoA hydratase
PCI15_RS15300	COG4770	biotin carboxylase activity
PCI15_RS15315	COG0318	PFAM AMP-dependent synthetase and ligase
PCI15_RS15320	COG2226	methyltransferase
PCI15_RS15340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS15345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS15350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS15360	COG0730	response to heat
PCI15_RS15365	COG0659	secondary active sulfate transmembrane transporter activity
PCI15_RS15370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PCI15_RS15395	COG0484	heat shock protein binding
PCI15_RS15405	COG2204	response regulator
PCI15_RS15410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PCI15_RS15415	COG3530	Putative quorum-sensing-regulated virulence factor
PCI15_RS15420	COG0633	Ferredoxin
PCI15_RS15420	COG3217	Mosc domain protein beta barrel domain protein
PCI15_RS15425	COG1444	tRNA N-acetyltransferase activity
PCI15_RS15445	COG0625	glutathione transferase activity
PCI15_RS15450	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS15475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PCI15_RS15475	COG0446	pyridine nucleotide-disulphide oxidoreductase
PCI15_RS15485	COG1238	metal cluster binding
PCI15_RS15490	COG0514	ATP-dependent DNA helicase (RecQ)
PCI15_RS15540	COG3210	domain, Protein
PCI15_RS15545	COG2831	hemolysin activation secretion protein
PCI15_RS15550	COG3133	Outer membrane lipoprotein
PCI15_RS15555	COG1132	(ABC) transporter
PCI15_RS15565	COG0271	Belongs to the BolA IbaG family
PCI15_RS15585	COG1196	nuclear chromosome segregation
PCI15_RS15600	COG1944	ATP diphosphatase activity
PCI15_RS15635	COG1362	aminopeptidase activity
PCI15_RS15660	COG3214	Protein conserved in bacteria
PCI15_RS15670	COG0039	L-malate dehydrogenase activity
PCI15_RS15675	COG1309	transcriptional regulator
PCI15_RS15695	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS15715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PCI15_RS15755	COG1741	Belongs to the pirin family
PCI15_RS15760	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS15770	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PCI15_RS15790	COG0348	domain, Protein
PCI15_RS15790	COG3901	Regulator of nitric oxide reductase transcription
PCI15_RS15815	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS15820	COG3302	dmso reductase anchor subunit
PCI15_RS15825	COG0437	4 iron, 4 sulfur cluster binding
PCI15_RS15830	COG0243	molybdopterin cofactor binding
PCI15_RS15835	COG0730	response to heat
PCI15_RS15860	COG0589	response to stress
PCI15_RS15875	COG1940	carbohydrate kinase activity
PCI15_RS15875	COG1846	Transcriptional regulator
PCI15_RS15885	COG0641	radical SAM
PCI15_RS15890	COG3119	arylsulfatase activity
PCI15_RS15915	COG1414	Transcriptional regulator
PCI15_RS15920	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PCI15_RS15925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PCI15_RS15930	COG0076	glutamate decarboxylase activity
PCI15_RS15935	COG0583	DNA-binding transcription factor activity
PCI15_RS15940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PCI15_RS15955	COG0583	DNA-binding transcription factor activity
PCI15_RS15985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS15995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS15995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS16000	COG0589	response to stress
PCI15_RS16015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PCI15_RS16020	COG2853	Lipoprotein
PCI15_RS16030	COG1643	Atp-dependent helicase
PCI15_RS16035	COG0121	glutamine amidotransferase
PCI15_RS16045	COG0739	heme binding
PCI15_RS16055	COG1611	Belongs to the LOG family
PCI15_RS16060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PCI15_RS16065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PCI15_RS16075	COG2201	protein-glutamate methylesterase activity
PCI15_RS16080	COG0745	RESPONSE REGULATOR receiver
PCI15_RS16085	COG0668	transmembrane transport
PCI15_RS16090	COG1061	Type III restriction enzyme res subunit
PCI15_RS16110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PCI15_RS16130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PCI15_RS16145	COG3038	cytochrome b561
PCI15_RS16155	COG1278	Cold shock
PCI15_RS16160	COG3122	Protein conserved in bacteria
PCI15_RS16175	COG4191	Histidine kinase
PCI15_RS16175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PCI15_RS16185	COG1027	Aspartate ammonia-lyase
PCI15_RS16220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PCI15_RS16220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PCI15_RS16225	COG0509	glycine decarboxylation via glycine cleavage system
PCI15_RS16230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PCI15_RS16235	COG1760	l-serine dehydratase
PCI15_RS16245	COG1115	amino acid carrier protein
PCI15_RS16250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PCI15_RS16255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PCI15_RS16260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PCI15_RS16270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS16280	COG3048	D-serine ammonia-lyase activity
PCI15_RS16290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS16300	COG0243	molybdopterin cofactor binding
PCI15_RS16305	COG0840	transmembrane signaling receptor activity
PCI15_RS16315	COG1177	transmembrane transport
PCI15_RS16320	COG1176	ABC-type spermidine putrescine transport system, permease component I
PCI15_RS16325	COG3842	ATPase activity
PCI15_RS16345	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS16350	COG2431	L-lysine efflux transmembrane transporter activity
PCI15_RS16355	COG2197	response regulator
PCI15_RS16360	COG0513	Belongs to the DEAD box helicase family
PCI15_RS16365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PCI15_RS16370	COG0513	Belongs to the DEAD box helicase family
PCI15_RS16375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PCI15_RS16380	COG1522	sequence-specific DNA binding
PCI15_RS16400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PCI15_RS16405	COG1605	Chorismate mutase
PCI15_RS16405	COG0077	Prephenate dehydratase
PCI15_RS16415	COG0745	RESPONSE REGULATOR receiver
PCI15_RS16420	COG0642	Histidine kinase
PCI15_RS16440	COG0745	RESPONSE REGULATOR receiver
PCI15_RS16500	COG0395	ABC-type sugar transport system, permease component
PCI15_RS16510	COG3842	ATPase activity
PCI15_RS16515	COG3842	ATPase activity
PCI15_RS16520	COG3284	Transcriptional regulator
PCI15_RS16525	COG1968	undecaprenyl-diphosphatase activity
PCI15_RS16540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PCI15_RS16550	COG2205	protein histidine kinase activity
PCI15_RS16550	COG2770	Histidine kinase
PCI15_RS16555	COG0745	RESPONSE REGULATOR receiver
PCI15_RS16560	COG5499	transcription regulator containing HTH domain
PCI15_RS16590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PCI15_RS16595	COG1349	DNA-binding transcription factor activity
PCI15_RS16605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PCI15_RS16620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PCI15_RS16640	COG2814	Major facilitator Superfamily
PCI15_RS16645	COG1666	GTP binding
PCI15_RS16660	COG2096	Adenosyltransferase
PCI15_RS16675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PCI15_RS16705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PCI15_RS16730	COG1021	2,3-dihydroxybenzoate-AMP ligase
PCI15_RS16750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PCI15_RS16750	COG2226	methyltransferase
PCI15_RS16750	COG3433	isochorismatase activity
PCI15_RS16755	COG2814	Major facilitator Superfamily
PCI15_RS16760	COG4771	TonB-dependent receptor
PCI15_RS16770	COG1132	(ABC) transporter
PCI15_RS16775	COG1132	(ABC) transporter
PCI15_RS16780	COG1917	Cupin 2, conserved barrel domain protein
PCI15_RS16780	COG2207	Transcriptional regulator
PCI15_RS16795	COG0646	methionine synthase
PCI15_RS16795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PCI15_RS16810	COG0840	transmembrane signaling receptor activity
PCI15_RS16820	COG0840	transmembrane signaling receptor activity
PCI15_RS16825	COG1403	HNH endonuclease
PCI15_RS16845	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PCI15_RS16865	COG1278	Cold shock
PCI15_RS16875	COG4221	oxidoreductase activity
PCI15_RS16910	COG1917	Cupin 2, conserved barrel domain protein
PCI15_RS16910	COG2207	Transcriptional regulator
PCI15_RS16915	COG2084	Dehydrogenase
PCI15_RS16920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PCI15_RS16960	COG1522	sequence-specific DNA binding
PCI15_RS16970	COG0179	Fumarylacetoacetate (FAA) hydrolase
PCI15_RS16975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS16975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS16985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS17000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PCI15_RS17020	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS17025	COG1902	pentaerythritol trinitrate reductase activity
PCI15_RS17095	COG1715	Restriction endonuclease
PCI15_RS17115	COG0776	regulation of translation
PCI15_RS17120	COG0072	phenylalanine-tRNA ligase activity
PCI15_RS17125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PCI15_RS17130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PCI15_RS17135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PCI15_RS17140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PCI15_RS17145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PCI15_RS17150	COG1956	GAF domain-containing protein
PCI15_RS17165	COG0753	catalase activity
PCI15_RS17180	COG2186	Transcriptional regulator
PCI15_RS17185	COG0247	lactate metabolic process
PCI15_RS17190	COG1139	Iron-sulfur cluster binding protein
PCI15_RS17195	COG1556	Lactate utilization protein
PCI15_RS17235	COG4115	mRNA cleavage
PCI15_RS17250	COG1162	GTPase activity
PCI15_RS17260	COG1733	regulation of RNA biosynthetic process
PCI15_RS17270	COG5598	trimethylamine methyltransferase
PCI15_RS17275	COG0583	DNA-binding transcription factor activity
PCI15_RS17290	COG0513	Belongs to the DEAD box helicase family
PCI15_RS17295	COG4459	periplasmic nitrate reductase
PCI15_RS17300	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
PCI15_RS17300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PCI15_RS17310	COG0243	molybdopterin cofactor binding
PCI15_RS17315	COG0437	4 iron, 4 sulfur cluster binding
PCI15_RS17320	COG0348	domain, Protein
PCI15_RS17325	COG3043	anaerobic respiration
PCI15_RS17330	COG3005	denitrification pathway
PCI15_RS17335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PCI15_RS17355	COG4172	Belongs to the ABC transporter superfamily
PCI15_RS17360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PCI15_RS17370	COG0747	negative chemotaxis
PCI15_RS17385	COG2354	Protein conserved in bacteria
PCI15_RS17390	COG1802	Transcriptional regulator
PCI15_RS17405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PCI15_RS17410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS17415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS17430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PCI15_RS17440	COG3842	ATPase activity
PCI15_RS17445	COG1840	ABC-type Fe3 transport system, periplasmic component
PCI15_RS17470	COG2188	Transcriptional regulator
PCI15_RS17475	COG0417	DNA replication proofreading
PCI15_RS17495	COG3425	synthase
PCI15_RS17520	COG0137	argininosuccinate synthase activity
PCI15_RS17530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PCI15_RS17535	COG2814	Major facilitator Superfamily
PCI15_RS17540	COG0450	alkyl hydroperoxide reductase
PCI15_RS17545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PCI15_RS17550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PCI15_RS17555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PCI15_RS17560	COG0583	DNA-binding transcription factor activity
PCI15_RS17570	COG3706	GGDEF domain
PCI15_RS17575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PCI15_RS17590	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS17610	COG2267	carboxylic ester hydrolase activity
PCI15_RS17620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PCI15_RS17625	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS17630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS17635	COG4948	Mandelate Racemase Muconate Lactonizing
PCI15_RS17645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PCI15_RS17680	COG0583	DNA-binding transcription factor activity
PCI15_RS17685	COG0811	peptide transport
PCI15_RS17705	COG4774	siderophore transport
PCI15_RS17715	COG3128	pkhd-type hydroxylase
PCI15_RS17760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PCI15_RS17760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PCI15_RS17765	COG3706	GGDEF domain
PCI15_RS17775	COG0826	peptidase U32
PCI15_RS17790	COG0006	proline dipeptidase activity
PCI15_RS17795	COG0583	DNA-binding transcription factor activity
PCI15_RS17800	COG2866	Carboxypeptidase
PCI15_RS17805	COG4608	Belongs to the ABC transporter superfamily
PCI15_RS17810	COG0444	Belongs to the ABC transporter superfamily
PCI15_RS17815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PCI15_RS17820	COG0601	transmembrane transport
PCI15_RS17825	COG0747	negative chemotaxis
PCI15_RS17855	COG2358	TRAP transporter, solute receptor (TAXI family
PCI15_RS17870	COG2084	Dehydrogenase
PCI15_RS17875	COG0235	Class ii aldolase
PCI15_RS17890	COG5598	trimethylamine methyltransferase
PCI15_RS17920	COG5012	cobalamin binding
PCI15_RS17945	COG2315	Protein conserved in bacteria
PCI15_RS17950	COG2207	Transcriptional regulator
PCI15_RS17950	COG3708	Transcriptional regulator
PCI15_RS17955	COG0583	DNA-binding transcription factor activity
PCI15_RS17970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS17980	COG0454	-acetyltransferase
PCI15_RS17985	COG0456	acetyltransferase
PCI15_RS18030	COG0625	glutathione transferase activity
PCI15_RS18045	COG0346	lactoylglutathione lyase activity
PCI15_RS18060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS18070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS18070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS18095	COG1331	Highly conserved protein containing a thioredoxin domain
PCI15_RS18115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PCI15_RS18120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PCI15_RS18135	COG2010	Cytochrome c
PCI15_RS18140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PCI15_RS18170	COG4067	protein conserved in archaea
PCI15_RS18170	COG0189	ligase activity
PCI15_RS18225	COG4964	Belongs to the GSP D family
PCI15_RS18255	COG1846	Transcriptional regulator
PCI15_RS18265	COG1764	response to oxidative stress
PCI15_RS18280	COG0625	glutathione transferase activity
PCI15_RS18285	COG0583	DNA-binding transcription factor activity
PCI15_RS18305	COG2900	Belongs to the SlyX family
PCI15_RS18315	COG1968	undecaprenyl-diphosphatase activity
PCI15_RS18320	COG1214	PFAM Peptidase M22, glycoprotease
PCI15_RS18330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PCI15_RS18335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PCI15_RS18355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PCI15_RS18400	COG2197	response regulator
PCI15_RS18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PCI15_RS18445	COG1322	Protein conserved in bacteria
PCI15_RS18475	COG3784	Protein of unknown function (DUF1318)
PCI15_RS18505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PCI15_RS18515	COG0778	Nitroreductase
PCI15_RS18525	COG0842	Transport permease protein
PCI15_RS18530	COG1131	(ABC) transporter
PCI15_RS18600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PCI15_RS18605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PCI15_RS18610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PCI15_RS18615	COG2003	Belongs to the UPF0758 family
PCI15_RS18625	COG0756	dUTP diphosphatase activity
PCI15_RS18630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PCI15_RS18635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PCI15_RS18640	COG1309	transcriptional regulator
PCI15_RS18650	COG2861	carbohydrate metabolic process
PCI15_RS18655	COG0793	Belongs to the peptidase S41A family
PCI15_RS18660	COG4942	peptidase
PCI15_RS18665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PCI15_RS18670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PCI15_RS18680	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PCI15_RS18695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PCI15_RS18700	COG2204	response regulator
PCI15_RS18705	COG3852	Histidine kinase
PCI15_RS18715	COG0174	glutamine synthetase
PCI15_RS18720	COG1217	gtp-binding protein TYPA
PCI15_RS18730	COG1757	Na H antiporter
PCI15_RS18735	COG1490	D-aminoacyl-tRNA deacylase activity
PCI15_RS18745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS18760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS18770	COG0251	oxidation-reduction process
PCI15_RS18775	COG0251	oxidation-reduction process
PCI15_RS18780	COG1832	CoA-binding protein
PCI15_RS18790	COG2890	protein-(glutamine-N5) methyltransferase activity
PCI15_RS18795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PCI15_RS18800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PCI15_RS18810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PCI15_RS18820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PCI15_RS18830	COG0193	aminoacyl-tRNA hydrolase activity
PCI15_RS18835	COG0012	GTP binding
PCI15_RS18870	COG5001	Diguanylate cyclase
PCI15_RS18870	COG3300	MHYT domain
PCI15_RS18875	COG3830	Belongs to the UPF0237 family
PCI15_RS18875	COG0560	Phosphoserine phosphatase
PCI15_RS18880	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS18900	COG0517	IMP dehydrogenase activity
PCI15_RS18900	COG4175	Glycine betaine
PCI15_RS18905	COG4413	Urea transporter
PCI15_RS18920	COG3119	arylsulfatase activity
PCI15_RS18935	COG0557	exoribonuclease II activity
PCI15_RS18950	COG1862	Preprotein translocase
PCI15_RS18955	COG0343	queuine tRNA-ribosyltransferase activity
PCI15_RS18960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PCI15_RS18970	COG1309	transcriptional regulator
PCI15_RS18995	COG0582	viral genome integration into host DNA
PCI15_RS19050	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PCI15_RS19090	COG0583	DNA-binding transcription factor activity
PCI15_RS19105	COG0745	RESPONSE REGULATOR receiver
PCI15_RS19110	COG5002	protein histidine kinase activity
PCI15_RS19135	COG0545	Peptidyl-prolyl cis-trans isomerase
PCI15_RS19180	COG0604	alcohol dehydrogenase
PCI15_RS19185	COG2186	Transcriptional regulator
PCI15_RS19190	COG0666	response to abiotic stimulus
PCI15_RS19195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS19200	COG1733	regulation of RNA biosynthetic process
PCI15_RS19210	COG0655	NAD(P)H dehydrogenase (quinone) activity
PCI15_RS19215	COG5001	Diguanylate cyclase
PCI15_RS19215	COG1716	ATPase activity
PCI15_RS19230	COG5002	protein histidine kinase activity
PCI15_RS19275	COG5463	Belongs to the UPF0441 family
PCI15_RS19280	COG0754	glutathionylspermidine amidase activity
PCI15_RS19290	COG4774	siderophore transport
PCI15_RS19300	COG1595	DNA-templated transcription, initiation
PCI15_RS19305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PCI15_RS19315	COG0840	transmembrane signaling receptor activity
PCI15_RS19315	COG0840	transmembrane signaling receptor activity
PCI15_RS19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS19335	COG1858	cytochrome C peroxidase
PCI15_RS19345	COG0697	spore germination
PCI15_RS19370	COG3290	protein histidine kinase activity
PCI15_RS19375	COG4565	transcriptional regulatory protein
PCI15_RS19385	COG0259	pyridoxamine-phosphate oxidase activity
PCI15_RS19405	COG1450	Type ii and iii secretion system protein
PCI15_RS19460	COG1459	type II secretion system
PCI15_RS19465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PCI15_RS19470	COG2165	general secretion pathway protein
PCI15_RS19540	COG1116	anion transmembrane transporter activity
PCI15_RS19545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PCI15_RS19550	COG0583	DNA-binding transcription factor activity
PCI15_RS19575	COG3153	acetyltransferase
PCI15_RS19575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PCI15_RS19615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PCI15_RS19620	COG0789	Transcriptional regulator
PCI15_RS19635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS19655	COG1063	alcohol dehydrogenase
PCI15_RS19680	COG0583	DNA-binding transcription factor activity
PCI15_RS19695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PCI15_RS19715	COG4638	Rieske (2fe-2S)
PCI15_RS19720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS19725	COG0583	DNA-binding transcription factor activity
PCI15_RS19740	COG0583	DNA-binding transcription factor activity
PCI15_RS19750	COG2233	PERMEase
PCI15_RS19765	COG1309	transcriptional regulator
PCI15_RS19775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PCI15_RS19785	COG0402	S-adenosylhomocysteine deaminase activity
PCI15_RS19800	COG2252	PERMEase
PCI15_RS19805	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS19825	COG4266	Belongs to the allantoicase family
PCI15_RS19845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PCI15_RS19850	COG0028	Belongs to the TPP enzyme family
PCI15_RS19885	COG4191	Histidine kinase
PCI15_RS19890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS19895	COG0668	transmembrane transport
PCI15_RS19910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PCI15_RS19915	COG1119	ATPase activity
PCI15_RS19950	COG5001	Diguanylate cyclase
PCI15_RS19955	COG0745	RESPONSE REGULATOR receiver
PCI15_RS19965	COG0625	glutathione transferase activity
PCI15_RS19970	COG0583	DNA-binding transcription factor activity
PCI15_RS19975	COG0840	transmembrane signaling receptor activity
PCI15_RS19990	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS19995	COG2813	Specifically methylates the guanine in position
PCI15_RS20010	COG5002	protein histidine kinase activity
PCI15_RS20010	COG0784	Response regulator, receiver
PCI15_RS20010	COG2205	protein histidine kinase activity
PCI15_RS20025	COG2304	oxidoreductase activity
PCI15_RS20045	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PCI15_RS20075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PCI15_RS20085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PCI15_RS20090	COG2089	acid synthase
PCI15_RS20095	COG1083	cytidylyl-transferase
PCI15_RS20115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PCI15_RS20120	COG0107	imidazoleglycerol-phosphate synthase activity
PCI15_RS20135	COG0107	imidazoleglycerol-phosphate synthase activity
PCI15_RS20140	COG0367	asparagine synthase
PCI15_RS20160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PCI15_RS20165	COG0668	transmembrane transport
PCI15_RS20195	COG0406	alpha-ribazole phosphatase activity
PCI15_RS20215	COG0601	transmembrane transport
PCI15_RS20220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PCI15_RS20230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PCI15_RS20230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS20245	COG3089	Belongs to the UPF0270 family
PCI15_RS20250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PCI15_RS20255	COG3115	cell septum assembly
PCI15_RS20255	COG3115	cell septum assembly
PCI15_RS20275	COG1138	Cytochrome C-type biogenesis protein
PCI15_RS20280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PCI15_RS20300	COG4133	protoheme IX ABC transporter activity
PCI15_RS20310	COG2257	FlhB HrpN YscU SpaS Family
PCI15_RS20325	COG1192	Involved in chromosome partitioning
PCI15_RS20330	COG1360	Flagellar Motor Protein
PCI15_RS20335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PCI15_RS20345	COG0643	Histidine kinase
PCI15_RS20345	COG0784	Response regulator, receiver
PCI15_RS20345	COG2198	Histidine kinase
PCI15_RS20350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PCI15_RS20385	COG1684	flagellar biosynthetic protein fliR
PCI15_RS20390	COG1987	bacterial-type flagellum assembly
PCI15_RS20420	COG3144	bacterial-type flagellum assembly
PCI15_RS20440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PCI15_RS20450	COG1677	Flagellar hook-basal body complex protein FliE
PCI15_RS20465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PCI15_RS20475	COG2205	protein histidine kinase activity
PCI15_RS20475	COG0784	Response regulator, receiver
PCI15_RS20485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PCI15_RS20530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PCI15_RS20540	COG1705	Flagellar rod assembly protein muramidase FlgJ
PCI15_RS20540	COG3951	Flagellar rod assembly protein muramidase FlgJ
PCI15_RS20545	COG1706	bacterial-type flagellum-dependent cell motility
PCI15_RS20550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PCI15_RS20560	COG4786	Flagellar basal body rod
PCI15_RS20565	COG1749	Flagellar hook protein flgE
PCI15_RS20580	COG1815	bacterial-type flagellum-dependent cell motility
PCI15_RS20585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PCI15_RS20590	COG0835	chemotaxis
PCI15_RS20590	COG0784	Response regulator, receiver
PCI15_RS20600	COG2747	anti-sigma28 factor FlgM
PCI15_RS20615	COG0745	RESPONSE REGULATOR receiver
PCI15_RS20620	COG0123	including yeast histone deacetylase and acetoin utilization protein
PCI15_RS20625	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PCI15_RS20635	COG3630	sodium ion export across plasma membrane
PCI15_RS20640	COG0301	tRNA thio-modification
PCI15_RS20640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PCI15_RS20645	COG3706	GGDEF domain
PCI15_RS20650	COG2201	protein-glutamate methylesterase activity
PCI15_RS20660	COG2274	protein secretion by the type I secretion system
PCI15_RS20665	COG2274	protein secretion by the type I secretion system
PCI15_RS20695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PCI15_RS20700	COG0527	aspartate kinase activity
PCI15_RS20705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PCI15_RS20715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PCI15_RS20720	COG1546	Belongs to the CinA family
PCI15_RS20740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PCI15_RS20750	COG1187	pseudouridine synthase activity
PCI15_RS20765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PCI15_RS20795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PCI15_RS20825	COG0109	protoheme IX farnesyltransferase activity
PCI15_RS20830	COG1612	heme a metabolic process
PCI15_RS20855	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PCI15_RS20860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PCI15_RS20865	COG1565	acr, cog1565
PCI15_RS20865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PCI15_RS20875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PCI15_RS20880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PCI15_RS20885	COG1183	phosphatidylcholine synthase activity
PCI15_RS20890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PCI15_RS20890	COG0519	Catalyzes the synthesis of GMP from XMP
PCI15_RS20910	COG1496	oxidoreductase activity
PCI15_RS20935	COG1185	polyribonucleotide nucleotidyltransferase activity
PCI15_RS20940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PCI15_RS20950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PCI15_RS20955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PCI15_RS20960	COG0195	Participates in both transcription termination and antitermination
PCI15_RS20965	COG0779	Required for maturation of 30S ribosomal subunits
PCI15_RS20980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PCI15_RS20985	COG0149	triose-phosphate isomerase activity
PCI15_RS20990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PCI15_RS20995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PCI15_RS21000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PCI15_RS21005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PCI15_RS21020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PCI15_RS21035	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PCI15_RS21080	COG0709	Synthesizes selenophosphate from selenide and ATP
PCI15_RS21090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PCI15_RS21090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PCI15_RS21105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PCI15_RS21110	COG0583	DNA-binding transcription factor activity
PCI15_RS21160	COG3150	esterase
PCI15_RS21165	COG0583	DNA-binding transcription factor activity
PCI15_RS21180	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
PCI15_RS21195	COG0028	Belongs to the TPP enzyme family
PCI15_RS21205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PCI15_RS21210	COG0281	malic enzyme
PCI15_RS21215	COG0254	rRNA binding
PCI15_RS21220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PCI15_RS21225	COG0018	arginyl-trna synthetase
PCI15_RS21230	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PCI15_RS21235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PCI15_RS21240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PCI15_RS21250	COG2226	methyltransferase
PCI15_RS21260	COG1981	membrane
PCI15_RS21265	COG0179	Fumarylacetoacetate (FAA) hydrolase
PCI15_RS21270	COG3123	guanosine phosphorylase activity
PCI15_RS21295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PCI15_RS21315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PCI15_RS21325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PCI15_RS21335	COG0667	Aldo Keto reductase
PCI15_RS21345	COG0509	glycine decarboxylation via glycine cleavage system
PCI15_RS21350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PCI15_RS21355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PCI15_RS21360	COG0006	proline dipeptidase activity
PCI15_RS21365	COG3079	Belongs to the UPF0149 family
PCI15_RS21385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PCI15_RS21405	COG0840	transmembrane signaling receptor activity
PCI15_RS21410	COG0165	Argininosuccinate lyase
PCI15_RS21415	COG0181	hydroxymethylbilane synthase activity
PCI15_RS21420	COG1587	Uroporphyrinogen-III synthase
PCI15_RS21425	COG2959	enzyme of heme biosynthesis
PCI15_RS21445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PCI15_RS21460	COG0248	Ppx GppA phosphatase
PCI15_RS21465	COG2703	oxygen carrier activity
PCI15_RS21470	COG0203	ribosomal protein L17
PCI15_RS21485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PCI15_RS21490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PCI15_RS21495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PCI15_RS21505	COG0200	Binds to the 23S rRNA
PCI15_RS21510	COG1841	ribosomal large subunit assembly
PCI15_RS21515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PCI15_RS21520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PCI15_RS21525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PCI15_RS21530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PCI15_RS21535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PCI15_RS21540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PCI15_RS21545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PCI15_RS21550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PCI15_RS21555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PCI15_RS21560	COG0255	Belongs to the universal ribosomal protein uL29 family
PCI15_RS21565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PCI15_RS21570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PCI15_RS21575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PCI15_RS21580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PCI15_RS21585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PCI15_RS21590	COG0089	rRNA binding
PCI15_RS21595	COG0088	Forms part of the polypeptide exit tunnel
PCI15_RS21600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PCI15_RS21605	COG0051	transcription antitermination factor activity, RNA binding
PCI15_RS21610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PCI15_RS21615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PCI15_RS21620	COG0049	tRNA binding
PCI15_RS21625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PCI15_RS21630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PCI15_RS21635	COG0085	RNA polymerase activity
PCI15_RS21640	COG0222	ribosome binding
PCI15_RS21650	COG0081	regulation of translation
PCI15_RS21655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PCI15_RS21675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PCI15_RS21705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PCI15_RS21710	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PCI15_RS21710	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PCI15_RS21720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PCI15_RS21725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PCI15_RS21730	COG0730	response to heat
PCI15_RS21745	COG0494	nUDIX hydrolase
PCI15_RS21755	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS21760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PCI15_RS21770	COG0436	Aminotransferase
PCI15_RS21785	COG0642	Histidine kinase
PCI15_RS21805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PCI15_RS21840	COG0210	DNA helicase
PCI15_RS21860	COG0004	ammonium transporteR
PCI15_RS21895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PCI15_RS21910	COG2205	protein histidine kinase activity
PCI15_RS21915	COG0745	RESPONSE REGULATOR receiver
PCI15_RS21925	COG1573	uracil-dna glycosylase
PCI15_RS21930	COG1858	cytochrome C peroxidase
PCI15_RS21935	COG0471	metal ion transport
PCI15_RS21935	COG3273	potassium ion transport
PCI15_RS21940	COG0583	DNA-binding transcription factor activity
PCI15_RS21945	COG0191	fructose-bisphosphate aldolase activity
PCI15_RS21950	COG3588	fructose-bisphosphate aldolase
PCI15_RS21955	COG0126	phosphoglycerate kinase activity
PCI15_RS21965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PCI15_RS21970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PCI15_RS21975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PCI15_RS21980	COG0189	ligase activity
PCI15_RS21990	COG1678	Uncharacterized ACR, COG1678
PCI15_RS21995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PCI15_RS22000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PCI15_RS22005	COG0540	Belongs to the ATCase OTCase family
PCI15_RS22015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS22020	COG0626	cystathionine gamma-synthase activity
PCI15_RS22025	COG0583	DNA-binding transcription factor activity
PCI15_RS22030	COG2084	Dehydrogenase
PCI15_RS22080	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PCI15_RS22085	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS22105	COG3135	benzoate transporter
PCI15_RS22110	COG1396	sequence-specific DNA binding
PCI15_RS22130	COG3806	Anti-sigma factor
PCI15_RS22135	COG1595	DNA-templated transcription, initiation
PCI15_RS22150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PCI15_RS22155	COG2832	Protein of unknown function (DUF454)
PCI15_RS22160	COG0753	catalase activity
PCI15_RS22170	COG4221	oxidoreductase activity
PCI15_RS22205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PCI15_RS22210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PCI15_RS22220	COG3720	iron ion transport
PCI15_RS22225	COG4771	TonB-dependent receptor
PCI15_RS22230	COG4256	Hemin uptake protein
PCI15_RS22245	COG0848	biopolymer transport protein
PCI15_RS22250	COG0811	peptide transport
PCI15_RS22255	COG0811	peptide transport
PCI15_RS22285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PCI15_RS22300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS22355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PCI15_RS22360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PCI15_RS22400	COG2204	response regulator
PCI15_RS22405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS22410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS22415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS22420	COG0840	transmembrane signaling receptor activity
PCI15_RS22425	COG2204	response regulator
PCI15_RS22435	COG2183	response to ionizing radiation
PCI15_RS22485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PCI15_RS22490	COG3706	GGDEF domain
PCI15_RS22495	COG3041	Addiction module toxin RelE StbE family
PCI15_RS22510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS22515	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS22550	COG0583	DNA-binding transcription factor activity
PCI15_RS22555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PCI15_RS22575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS22580	COG0174	glutamine synthetase
PCI15_RS22585	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PCI15_RS22595	COG3842	ATPase activity
PCI15_RS22600	COG1176	ABC-type spermidine putrescine transport system, permease component I
PCI15_RS22605	COG1177	transmembrane transport
PCI15_RS22610	COG0519	Catalyzes the synthesis of GMP from XMP
PCI15_RS22615	COG1653	transport
PCI15_RS22625	COG0395	ABC-type sugar transport system, permease component
PCI15_RS22630	COG3842	ATPase activity
PCI15_RS22655	COG0583	DNA-binding transcription factor activity
PCI15_RS22660	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS22670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS22685	COG0714	Associated with various cellular activities
PCI15_RS22695	COG0251	oxidation-reduction process
PCI15_RS22700	COG0583	DNA-binding transcription factor activity
PCI15_RS22725	COG0545	Peptidyl-prolyl cis-trans isomerase
PCI15_RS22735	COG0488	(ABC) transporter
PCI15_RS22740	COG1280	lysine exporter protein (LysE YggA)
PCI15_RS22750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PCI15_RS22755	COG1758	RNA polymerase activity
PCI15_RS22780	COG3220	belongs to the UPF0276 family
PCI15_RS22795	COG5001	Diguanylate cyclase
PCI15_RS22795	COG1716	ATPase activity
PCI15_RS22820	COG0745	RESPONSE REGULATOR receiver
PCI15_RS22825	COG5002	protein histidine kinase activity
PCI15_RS22840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PCI15_RS22920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PCI15_RS22925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PCI15_RS22935	COG0140	phosphoribosyl-ATP diphosphatase activity
PCI15_RS22940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PCI15_RS22945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PCI15_RS22965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PCI15_RS22980	COG1733	regulation of RNA biosynthetic process
PCI15_RS22985	COG1028	Short-chain dehydrogenase reductase Sdr
PCI15_RS23005	COG1278	Cold shock
PCI15_RS23010	COG0557	exoribonuclease II activity
PCI15_RS23015	COG0210	DNA helicase
PCI15_RS23025	COG0840	transmembrane signaling receptor activity
PCI15_RS23040	COG0573	inorganic phosphate transmembrane transporter activity
PCI15_RS23045	COG0573	inorganic phosphate transmembrane transporter activity
PCI15_RS23050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PCI15_RS23065	COG2203	Gaf domain
PCI15_RS23065	COG4251	negative regulation of phosphorylation
PCI15_RS23065	COG5001	Diguanylate cyclase
PCI15_RS23065	COG3706	GGDEF domain
PCI15_RS23080	COG3161	chorismate lyase activity
PCI15_RS23085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PCI15_RS23100	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PCI15_RS23105	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PCI15_RS23115	COG0604	alcohol dehydrogenase
PCI15_RS23160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PCI15_RS23165	COG1737	Transcriptional regulator
PCI15_RS23180	COG0069	glutamate synthase activity
PCI15_RS23200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PCI15_RS23205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PCI15_RS23210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PCI15_RS23215	COG1473	amidohydrolase
PCI15_RS23225	COG1522	sequence-specific DNA binding
PCI15_RS23235	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PCI15_RS23265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PCI15_RS23275	COG2095	MarC family integral membrane protein
PCI15_RS23280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PCI15_RS23285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PCI15_RS23310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PCI15_RS23335	COG0583	DNA-binding transcription factor activity
PCI15_RS23340	COG1126	abc transporter atp-binding protein
PCI15_RS23345	COG0765	amino acid transport
PCI15_RS23370	COG1012	belongs to the aldehyde dehydrogenase family
PCI15_RS23375	COG4977	sequence-specific DNA binding
PCI15_RS23385	COG1902	pentaerythritol trinitrate reductase activity
PCI15_RS23385	COG0446	pyridine nucleotide-disulphide oxidoreductase
PCI15_RS23395	COG0583	DNA-binding transcription factor activity
PCI15_RS23415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PCI15_RS23450	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
PCI15_RS23455	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
PCI15_RS23460	COG0513	Belongs to the DEAD box helicase family
PCI15_RS23470	COG0318	PFAM AMP-dependent synthetase and ligase
PCI15_RS23475	COG0789	Transcriptional regulator
PCI15_RS23480	COG0183	Belongs to the thiolase family
PCI15_RS23485	COG1024	Enoyl-CoA hydratase
PCI15_RS23485	COG1250	3-hydroxyacyl-CoA dehydrogenase
PCI15_RS23490	COG1960	acyl-CoA dehydrogenase activity
PCI15_RS23495	COG4628	conserved protein (DUF2132)
PCI15_RS23500	COG2226	methyltransferase
PCI15_RS23515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PCI15_RS23520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PCI15_RS23525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PCI15_RS23530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PCI15_RS23535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PCI15_RS23545	COG0356	it plays a direct role in the translocation of protons across the membrane
PCI15_RS23555	COG1475	DNA binding
PCI15_RS23560	COG1192	Involved in chromosome partitioning
PCI15_RS23565	COG0357	Ribosomal RNA small subunit methyltransferase G
PCI15_RS23570	COG0445	tRNA wobble uridine modification
PCI15_RS23575	COG0840	transmembrane signaling receptor activity
PCI15_RS23585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PCI15_RS23635	COG3118	belongs to the thioredoxin family
PCI15_RS23660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PCI15_RS23665	COG0706	membrane insertase activity
PCI15_RS23670	COG0594	ribonuclease P activity
PCI15_RS23675	COG0230	Belongs to the bacterial ribosomal protein bL34 family