locus-tag	class	description
A7H1H_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7H1H_RS00010	COG0592	DNA-directed DNA polymerase activity
A7H1H_RS00015	COG0187	DNA topoisomerase II activity
A7H1H_RS00020	COG0492	ferredoxin-NADP+ reductase activity
A7H1H_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7H1H_RS00035	COG1238	metal cluster binding
A7H1H_RS00040	COG0500	methyltransferase
A7H1H_RS00045	COG3842	ATPase activity
A7H1H_RS00090	COG0564	pseudouridine synthase activity
A7H1H_RS00095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7H1H_RS00100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7H1H_RS00105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7H1H_RS00135	COG0604	alcohol dehydrogenase
A7H1H_RS00140	COG1733	regulation of RNA biosynthetic process
A7H1H_RS00145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7H1H_RS00150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7H1H_RS00170	COG1620	l-lactate permease
A7H1H_RS00175	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS00180	COG3852	Histidine kinase
A7H1H_RS00185	COG1556	Lactate utilization protein
A7H1H_RS00190	COG1139	Iron-sulfur cluster binding protein
A7H1H_RS00195	COG0247	lactate metabolic process
A7H1H_RS00200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7H1H_RS00205	COG0511	ligase activity, forming carbon-carbon bonds
A7H1H_RS00210	COG0439	Biotin carboxylase
A7H1H_RS00215	COG0513	Belongs to the DEAD box helicase family
A7H1H_RS00220	COG0306	phosphate transporter
A7H1H_RS00230	COG0367	asparagine synthase
A7H1H_RS00240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7H1H_RS00245	COG1981	membrane
A7H1H_RS00250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A7H1H_RS00250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7H1H_RS00255	COG1187	pseudouridine synthase activity
A7H1H_RS00260	COG0517	IMP dehydrogenase activity
A7H1H_RS00260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A7H1H_RS00265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A7H1H_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7H1H_RS00275	COG0107	imidazoleglycerol-phosphate synthase activity
A7H1H_RS00290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7H1H_RS00295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7H1H_RS00300	COG0724	RNA recognition motif
A7H1H_RS00305	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS00310	COG0642	Histidine kinase
A7H1H_RS00365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7H1H_RS00370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7H1H_RS00375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7H1H_RS00390	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7H1H_RS00395	COG0746	molybdenum cofactor guanylyltransferase activity
A7H1H_RS00400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7H1H_RS00415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7H1H_RS00420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7H1H_RS00425	COG0268	Binds directly to 16S ribosomal RNA
A7H1H_RS00430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7H1H_RS00440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7H1H_RS00445	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A7H1H_RS00450	COG0573	inorganic phosphate transmembrane transporter activity
A7H1H_RS00455	COG0581	inorganic phosphate transmembrane transporter activity
A7H1H_RS00460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7H1H_RS00465	COG0704	Plays a role in the regulation of phosphate uptake
A7H1H_RS00475	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS00480	COG5002	protein histidine kinase activity
A7H1H_RS00485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7H1H_RS00490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7H1H_RS00500	COG0546	phosphoglycolate phosphatase activity
A7H1H_RS00520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7H1H_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7H1H_RS00540	COG1854	S-ribosylhomocysteine lyase activity
A7H1H_RS00555	COG1686	Belongs to the peptidase S11 family
A7H1H_RS00570	COG0646	methionine synthase
A7H1H_RS00570	COG1410	methionine synthase
A7H1H_RS00590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7H1H_RS00590	COG0140	phosphoribosyl-ATP diphosphatase activity
A7H1H_RS00600	COG0489	protein tyrosine kinase activity
A7H1H_RS00605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7H1H_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7H1H_RS00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7H1H_RS00625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A7H1H_RS00630	COG0505	Belongs to the CarA family
A7H1H_RS00640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7H1H_RS00645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A7H1H_RS00650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7H1H_RS00655	COG2353	YceI-like domain
A7H1H_RS00660	COG1846	Transcriptional regulator
A7H1H_RS00685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7H1H_RS00690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7H1H_RS00695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A7H1H_RS00700	COG0237	dephospho-CoA kinase activity
A7H1H_RS00705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7H1H_RS00710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7H1H_RS00715	COG0456	acetyltransferase
A7H1H_RS00785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7H1H_RS00790	COG0254	rRNA binding
A7H1H_RS00795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7H1H_RS00810	COG0436	Aminotransferase
A7H1H_RS00815	COG0460	homoserine dehydrogenase
A7H1H_RS00825	COG0575	Belongs to the CDS family
A7H1H_RS00830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7H1H_RS00845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7H1H_RS00850	COG0023	Translation Initiation Factor
A7H1H_RS00855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7H1H_RS00855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7H1H_RS00860	COG1324	tolerance protein
A7H1H_RS00865	COG2022	thiamine diphosphate biosynthetic process
A7H1H_RS00940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7H1H_RS00950	COG1346	cytolysis
A7H1H_RS00960	COG3766	membrane
A7H1H_RS00965	COG1301	dicarboxylic acid transport
A7H1H_RS00975	COG0204	Acyl-transferase
A7H1H_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
A7H1H_RS00980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7H1H_RS00995	COG0666	response to abiotic stimulus
A7H1H_RS01005	COG0418	dihydroorotase activity
A7H1H_RS01015	COG1706	bacterial-type flagellum-dependent cell motility
A7H1H_RS01050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A7H1H_RS01075	COG0037	tRNA processing
A7H1H_RS01080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7H1H_RS01085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7H1H_RS01090	COG0601	transmembrane transport
A7H1H_RS01095	COG0736	holo-[acyl-carrier-protein] synthase activity
A7H1H_RS01100	COG0786	glutamate:sodium symporter activity
A7H1H_RS01105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7H1H_RS01115	COG0560	Phosphoserine phosphatase
A7H1H_RS01125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A7H1H_RS01130	COG3248	Nucleoside-binding outer membrane protein
A7H1H_RS01135	COG1393	Belongs to the ArsC family
A7H1H_RS01140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7H1H_RS01145	COG0343	queuine tRNA-ribosyltransferase activity
A7H1H_RS01155	COG0436	Aminotransferase
A7H1H_RS01175	COG2861	carbohydrate metabolic process
A7H1H_RS01180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7H1H_RS01185	COG0557	exoribonuclease II activity
A7H1H_RS01190	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A7H1H_RS01200	COG0360	Binds together with S18 to 16S ribosomal RNA
A7H1H_RS01205	COG0629	single-stranded DNA binding
A7H1H_RS01210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7H1H_RS01220	COG0215	cysteine-tRNA ligase activity
A7H1H_RS01225	COG0195	Participates in both transcription termination and antitermination
A7H1H_RS01235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7H1H_RS01240	COG2121	Domain of unknown function (DUF374)
A7H1H_RS01250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7H1H_RS01260	COG0288	reversible hydration of carbon dioxide
A7H1H_RS01265	COG0156	8-amino-7-oxononanoate synthase activity
A7H1H_RS01270	COG0792	nuclease activity
A7H1H_RS01290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7H1H_RS01300	COG0540	Belongs to the ATCase OTCase family
A7H1H_RS01305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7H1H_RS01315	COG2824	Alkylphosphonate utilization operon protein PhnA
A7H1H_RS01320	COG1451	nucleotide metabolic process
A7H1H_RS01325	COG0730	response to heat
A7H1H_RS01355	COG3328	transposase activity
A7H1H_RS01360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7H1H_RS01370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A7H1H_RS01375	COG0372	Belongs to the citrate synthase family
A7H1H_RS01380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7H1H_RS01385	COG2828	Protein conserved in bacteria
A7H1H_RS01395	COG1335	isochorismatase
A7H1H_RS01400	COG0181	hydroxymethylbilane synthase activity
A7H1H_RS01410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7H1H_RS01415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7H1H_RS01420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7H1H_RS01425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7H1H_RS01430	COG0450	alkyl hydroperoxide reductase
A7H1H_RS01440	COG0105	UTP biosynthetic process
A7H1H_RS01450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7H1H_RS01455	COG0416	fatty acid biosynthetic process
A7H1H_RS01460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7H1H_RS01480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7H1H_RS01485	COG1053	succinate dehydrogenase
A7H1H_RS01495	COG1007	ATP synthesis coupled electron transport
A7H1H_RS01505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7H1H_RS01510	COG0713	ATP synthesis coupled electron transport
A7H1H_RS01515	COG0839	Belongs to the complex I subunit 6 family
A7H1H_RS01520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7H1H_RS01525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7H1H_RS01530	COG1034	ATP synthesis coupled electron transport
A7H1H_RS01535	COG0372	Belongs to the citrate synthase family
A7H1H_RS01550	COG0649	NAD binding
A7H1H_RS01550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7H1H_RS01555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7H1H_RS01560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7H1H_RS01565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7H1H_RS01570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7H1H_RS01575	COG3610	response to peptide
A7H1H_RS01580	COG2966	Psort location CytoplasmicMembrane, score
A7H1H_RS01590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A7H1H_RS01595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7H1H_RS01645	COG4771	TonB-dependent receptor
A7H1H_RS01655	COG1971	Probably functions as a manganese efflux pump
A7H1H_RS01670	COG1132	(ABC) transporter
A7H1H_RS01675	COG1132	(ABC) transporter
A7H1H_RS01675	COG2375	cellular response to nickel ion
A7H1H_RS01680	COG4771	TonB-dependent receptor
A7H1H_RS01705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7H1H_RS01710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7H1H_RS01710	COG1333	cytochrome c biogenesis protein
A7H1H_RS01715	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A7H1H_RS01720	COG3005	denitrification pathway
A7H1H_RS01730	COG2199	diguanylate cyclase activity
A7H1H_RS01730	COG3287	FIST C domain
A7H1H_RS01730	COG2200	EAL domain
A7H1H_RS01735	COG0840	transmembrane signaling receptor activity
A7H1H_RS01755	COG3043	anaerobic respiration
A7H1H_RS01760	COG0348	domain, Protein
A7H1H_RS01765	COG0437	4 iron, 4 sulfur cluster binding
A7H1H_RS01770	COG0243	molybdopterin cofactor binding
A7H1H_RS01780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A7H1H_RS01785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A7H1H_RS01795	COG2204	response regulator
A7H1H_RS01800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7H1H_RS01805	COG1648	precorrin-2 dehydrogenase activity
A7H1H_RS01805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7H1H_RS01820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7H1H_RS01825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7H1H_RS01830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7H1H_RS01840	COG2404	hydrolase activity, acting on ester bonds
A7H1H_RS01845	COG1832	CoA-binding protein
A7H1H_RS01850	COG0642	Histidine kinase
A7H1H_RS01855	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS01860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7H1H_RS01865	COG0191	fructose-bisphosphate aldolase activity
A7H1H_RS01885	COG0811	peptide transport
A7H1H_RS01895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7H1H_RS01900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7H1H_RS01910	COG0142	geranyltranstransferase activity
A7H1H_RS01915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7H1H_RS01920	COG0442	prolyl-tRNA aminoacylation
A7H1H_RS01925	COG0668	transmembrane transport
A7H1H_RS01945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7H1H_RS01950	COG1862	Preprotein translocase
A7H1H_RS01955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7H1H_RS01960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7H1H_RS01975	COG1360	Flagellar Motor Protein
A7H1H_RS01980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A7H1H_RS01990	COG0495	leucyl-tRNA aminoacylation
A7H1H_RS02000	COG0285	dihydrofolate synthase activity
A7H1H_RS02040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7H1H_RS02060	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS02065	COG0642	Histidine kinase
A7H1H_RS02070	COG2081	HI0933 family
A7H1H_RS02075	COG0840	transmembrane signaling receptor activity
A7H1H_RS02090	COG5002	protein histidine kinase activity
A7H1H_RS02095	COG1692	metallophosphoesterase
A7H1H_RS02110	COG2226	methyltransferase
A7H1H_RS02115	COG1570	exodeoxyribonuclease VII activity
A7H1H_RS02120	COG0835	chemotaxis
A7H1H_RS02125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7H1H_RS02130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7H1H_RS02135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7H1H_RS02145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7H1H_RS02150	COG0459	protein refolding
A7H1H_RS02160	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS02165	COG1408	metallophosphoesterase
A7H1H_RS02190	COG1136	(ABC) transporter
A7H1H_RS02210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7H1H_RS02215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7H1H_RS02220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7H1H_RS02225	COG0352	thiamine-phosphate diphosphorylase activity
A7H1H_RS02230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7H1H_RS02240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7H1H_RS02245	COG2264	protein methyltransferase activity
A7H1H_RS02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7H1H_RS02260	COG2207	Transcriptional regulator
A7H1H_RS02260	COG4753	response regulator
A7H1H_RS02265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7H1H_RS02280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7H1H_RS02315	COG1132	(ABC) transporter
A7H1H_RS02335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7H1H_RS02340	COG1090	epimerase
A7H1H_RS02345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7H1H_RS02365	COG0481	GTPase activity
A7H1H_RS02370	COG1937	Protein conserved in bacteria
A7H1H_RS02385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7H1H_RS02395	COG0482	sulfurtransferase activity
A7H1H_RS02400	COG0482	sulfurtransferase activity
A7H1H_RS02405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7H1H_RS02410	COG0006	proline dipeptidase activity
A7H1H_RS02415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7H1H_RS02420	COG0402	S-adenosylhomocysteine deaminase activity
A7H1H_RS02425	COG0616	signal peptide processing
A7H1H_RS02475	COG0280	phosphate acetyltransferase
A7H1H_RS02480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7H1H_RS02490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7H1H_RS02495	COG2176	DNA-directed DNA polymerase activity
A7H1H_RS02525	COG2176	DNA-directed DNA polymerase activity
A7H1H_RS02535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7H1H_RS02550	COG5002	protein histidine kinase activity
A7H1H_RS02595	COG1058	Belongs to the CinA family
A7H1H_RS02595	COG1546	Belongs to the CinA family
A7H1H_RS02600	COG0579	oxidoreductase
A7H1H_RS02605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7H1H_RS02620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7H1H_RS02635	COG0667	Aldo Keto reductase
A7H1H_RS02640	COG0306	phosphate transporter
A7H1H_RS02645	COG0840	transmembrane signaling receptor activity
A7H1H_RS02655	COG0840	transmembrane signaling receptor activity
A7H1H_RS02675	COG0824	Thioesterase
A7H1H_RS02685	COG0501	Belongs to the peptidase M48B family
A7H1H_RS02690	COG1322	Protein conserved in bacteria
A7H1H_RS02710	COG0037	tRNA processing
A7H1H_RS02730	COG0052	Belongs to the universal ribosomal protein uS2 family
A7H1H_RS02735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7H1H_RS02740	COG1136	(ABC) transporter
A7H1H_RS02750	COG0194	GDP metabolic process
A7H1H_RS02755	COG5001	Diguanylate cyclase
A7H1H_RS02755	COG5002	protein histidine kinase activity
A7H1H_RS02760	COG2217	Heavy metal translocating P-type atpase
A7H1H_RS02775	COG4608	Belongs to the ABC transporter superfamily
A7H1H_RS02780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7H1H_RS02785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A7H1H_RS02795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7H1H_RS02800	COG1121	(ABC) transporter
A7H1H_RS02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7H1H_RS02815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7H1H_RS02835	COG0210	DNA helicase
A7H1H_RS02840	COG0475	glutathione-regulated potassium exporter activity
A7H1H_RS02840	COG0569	domain protein
A7H1H_RS02845	COG0525	valine-tRNA ligase activity
A7H1H_RS02850	COG4895	conserved protein (DUF2196)
A7H1H_RS02870	COG2814	Major facilitator Superfamily
A7H1H_RS02875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7H1H_RS02895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7H1H_RS02900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7H1H_RS02905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7H1H_RS02915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7H1H_RS02945	COG0439	Biotin carboxylase
A7H1H_RS02950	COG2151	metal-sulfur cluster biosynthetic enzyme
A7H1H_RS02955	COG2166	iron-sulfur cluster assembly
A7H1H_RS02960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7H1H_RS02970	COG0396	ATPase activity
A7H1H_RS02975	COG0719	Fe-S assembly protein
A7H1H_RS02985	COG0822	iron-sulfur transferase activity
A7H1H_RS02985	COG2906	2 iron, 2 sulfur cluster binding
A7H1H_RS02985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7H1H_RS02990	COG2239	Acts as a magnesium transporter
A7H1H_RS02995	COG3706	GGDEF domain
A7H1H_RS03000	COG0165	Argininosuccinate lyase
A7H1H_RS03005	COG0784	Response regulator, receiver
A7H1H_RS03005	COG0835	chemotaxis
A7H1H_RS03010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7H1H_RS03015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7H1H_RS03025	COG0556	nucleotide-excision repair
A7H1H_RS03040	COG3328	transposase activity
A7H1H_RS03045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7H1H_RS03065	COG3328	transposase activity
A7H1H_RS03070	COG0840	transmembrane signaling receptor activity
A7H1H_RS03085	COG0698	ribose 5-phosphate isomerase
A7H1H_RS03090	COG0681	Belongs to the peptidase S26 family
A7H1H_RS03095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7H1H_RS03100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7H1H_RS03105	COG0193	aminoacyl-tRNA hydrolase activity
A7H1H_RS03120	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7H1H_RS03130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7H1H_RS03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7H1H_RS03145	COG0528	UMP kinase activity
A7H1H_RS03155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7H1H_RS03160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7H1H_RS03165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7H1H_RS03175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7H1H_RS03180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7H1H_RS03190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7H1H_RS03200	COG0305	Participates in initiation and elongation during chromosome replication
A7H1H_RS03260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7H1H_RS03340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7H1H_RS03345	COG1086	Polysaccharide biosynthesis protein
A7H1H_RS03355	COG1793	dna ligase
A7H1H_RS03360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7H1H_RS03365	COG0133	tryptophan synthase activity
A7H1H_RS03375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7H1H_RS03385	COG0848	biopolymer transport protein
A7H1H_RS03405	COG0577	efflux transmembrane transporter activity
A7H1H_RS03405	COG1136	(ABC) transporter
A7H1H_RS03410	COG0577	efflux transmembrane transporter activity
A7H1H_RS03410	COG1136	(ABC) transporter
A7H1H_RS03455	COG0735	belongs to the Fur family
A7H1H_RS03465	COG0114	fumarate hydratase activity
A7H1H_RS03475	COG3328	transposase activity
A7H1H_RS03480	COG3920	Histidine kinase
A7H1H_RS03485	COG0784	Response regulator, receiver
A7H1H_RS03490	COG4771	TonB-dependent receptor
A7H1H_RS03495	COG2819	hydrolase of the alpha beta superfamily
A7H1H_RS03500	COG0500	methyltransferase
A7H1H_RS03520	COG1966	Carbon starvation protein
A7H1H_RS03525	COG0012	GTP binding
A7H1H_RS03545	COG3123	guanosine phosphorylase activity
A7H1H_RS03555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7H1H_RS03560	COG0585	pseudouridine synthase activity
A7H1H_RS03570	COG0840	transmembrane signaling receptor activity
A7H1H_RS03575	COG0632	four-way junction helicase activity
A7H1H_RS03580	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7H1H_RS03605	COG0051	transcription antitermination factor activity, RNA binding
A7H1H_RS03610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7H1H_RS03615	COG0088	Forms part of the polypeptide exit tunnel
A7H1H_RS03620	COG0089	rRNA binding
A7H1H_RS03625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7H1H_RS03630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7H1H_RS03635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7H1H_RS03640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7H1H_RS03645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7H1H_RS03650	COG0255	Belongs to the universal ribosomal protein uL29 family
A7H1H_RS03655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7H1H_RS03660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7H1H_RS03665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7H1H_RS03670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7H1H_RS03675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7H1H_RS03680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7H1H_RS03685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7H1H_RS03690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7H1H_RS03695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7H1H_RS03700	COG0200	Binds to the 23S rRNA
A7H1H_RS03705	COG0201	protein transport
A7H1H_RS03710	COG0024	Methionine aminopeptidase
A7H1H_RS03715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7H1H_RS03720	COG1573	uracil-dna glycosylase
A7H1H_RS03730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7H1H_RS03745	COG1032	radical SAM domain protein
A7H1H_RS03755	COG0563	adenylate kinase activity
A7H1H_RS03775	COG1064	alcohol dehydrogenase
A7H1H_RS03780	COG1979	alcohol dehydrogenase
A7H1H_RS03785	COG0840	transmembrane signaling receptor activity
A7H1H_RS03790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7H1H_RS03795	COG0322	excinuclease ABC activity
A7H1H_RS03800	COG0840	transmembrane signaling receptor activity
A7H1H_RS03810	COG0840	transmembrane signaling receptor activity
A7H1H_RS03815	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS03825	COG2205	protein histidine kinase activity
A7H1H_RS03825	COG0784	Response regulator, receiver
A7H1H_RS03875	COG0829	nickel cation binding
A7H1H_RS03880	COG0832	Belongs to the urease beta subunit family
A7H1H_RS03880	COG0831	urea catabolic process
A7H1H_RS03885	COG0804	urea catabolic process
A7H1H_RS03890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A7H1H_RS03900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7H1H_RS03940	COG0708	Exodeoxyribonuclease III
A7H1H_RS03960	COG3040	lipid binding
A7H1H_RS03975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7H1H_RS03985	COG2200	EAL domain
A7H1H_RS03990	COG3279	Response regulator of the LytR AlgR family
A7H1H_RS03995	COG3275	phosphorelay sensor kinase activity
A7H1H_RS04000	COG1233	COG1233 Phytoene dehydrogenase and related
A7H1H_RS04005	COG0415	Belongs to the DNA photolyase family
A7H1H_RS04025	COG0166	Belongs to the GPI family
A7H1H_RS04070	COG0840	transmembrane signaling receptor activity
A7H1H_RS04075	COG1942	4-Oxalocrotonate Tautomerase
A7H1H_RS04080	COG0583	DNA-binding transcription factor activity
A7H1H_RS04085	COG0134	indole-3-glycerol-phosphate synthase activity
A7H1H_RS04095	COG0727	PFAM Uncharacterised protein family (UPF0153)
A7H1H_RS04100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7H1H_RS04110	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7H1H_RS04110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7H1H_RS04115	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7H1H_RS04125	COG2176	DNA-directed DNA polymerase activity
A7H1H_RS04130	COG0135	phosphoribosylanthranilate isomerase activity
A7H1H_RS04135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7H1H_RS04155	COG1666	GTP binding
A7H1H_RS04165	COG2363	Small membrane protein
A7H1H_RS04170	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A7H1H_RS04185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7H1H_RS04240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A7H1H_RS04260	COG3177	Filamentation induced by cAMP protein fic
A7H1H_RS04270	COG1204	response to ionizing radiation
A7H1H_RS04315	COG0750	zinc metalloprotease
A7H1H_RS04320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7H1H_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
A7H1H_RS04330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7H1H_RS04340	COG0167	dihydroorotate dehydrogenase activity
A7H1H_RS04345	COG1132	(ABC) transporter
A7H1H_RS04350	COG0728	peptidoglycan biosynthetic process
A7H1H_RS04365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7H1H_RS04375	COG3328	transposase activity
A7H1H_RS04380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7H1H_RS04385	COG3150	esterase
A7H1H_RS04395	COG0552	protein localization to endoplasmic reticulum
A7H1H_RS04400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7H1H_RS04405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7H1H_RS04410	COG1418	mRNA catabolic process
A7H1H_RS04415	COG0742	ribosomal rna small subunit methyltransferase
A7H1H_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7H1H_RS04425	COG0300	oxidoreductase activity
A7H1H_RS04460	COG3258	Cytochrome c
A7H1H_RS04470	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS04475	COG0642	Histidine kinase
A7H1H_RS04480	COG0157	Belongs to the NadC ModD family
A7H1H_RS04490	COG1610	YqeY-like protein
A7H1H_RS04495	COG0488	(ABC) transporter
A7H1H_RS04505	COG0492	ferredoxin-NADP+ reductase activity
A7H1H_RS04510	COG0596	Alpha beta hydrolase
A7H1H_RS04565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7H1H_RS04565	COG0519	Catalyzes the synthesis of GMP from XMP
A7H1H_RS04570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A7H1H_RS04580	COG1451	nucleotide metabolic process
A7H1H_RS04585	COG0436	Aminotransferase
A7H1H_RS04590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7H1H_RS04605	COG1696	Membrane protein involved in D-alanine export
A7H1H_RS04615	COG2223	nitrite transmembrane transporter activity
A7H1H_RS04625	COG0310	cobalt ion transport
A7H1H_RS04660	COG3077	Addiction module antitoxin, RelB DinJ family
A7H1H_RS04675	COG0628	permease
A7H1H_RS04700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7H1H_RS04710	COG0840	transmembrane signaling receptor activity
A7H1H_RS04715	COG2199	diguanylate cyclase activity
A7H1H_RS04715	COG2200	EAL domain
A7H1H_RS04715	COG3287	FIST C domain
A7H1H_RS04720	COG0840	transmembrane signaling receptor activity
A7H1H_RS04725	COG0840	transmembrane signaling receptor activity
A7H1H_RS04735	COG0730	response to heat
A7H1H_RS04740	COG1045	serine acetyltransferase
A7H1H_RS04745	COG1166	arginine decarboxylase activity
A7H1H_RS04750	COG0124	histidyl-tRNA synthetase
A7H1H_RS04755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7H1H_RS04760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7H1H_RS04765	COG0163	prenyltransferase activity
A7H1H_RS04775	COG0359	binds to the 23S rRNA
A7H1H_RS04780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7H1H_RS04785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7H1H_RS04795	COG0084	hydrolase, TatD family'
A7H1H_RS04805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7H1H_RS04810	COG0131	Imidazoleglycerol-phosphate dehydratase
A7H1H_RS04815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7H1H_RS04830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7H1H_RS04835	COG0456	acetyltransferase
A7H1H_RS04840	COG1595	DNA-templated transcription, initiation
A7H1H_RS04890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7H1H_RS04905	COG3437	response regulator, receiver
A7H1H_RS04905	COG0784	Response regulator, receiver
A7H1H_RS04915	COG0768	penicillin binding
A7H1H_RS04935	COG2884	Cell division ATP-binding protein ftsE
A7H1H_RS04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7H1H_RS04950	COG0564	pseudouridine synthase activity
A7H1H_RS04955	COG0772	Belongs to the SEDS family
A7H1H_RS04965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7H1H_RS04970	COG3123	guanosine phosphorylase activity
A7H1H_RS04990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7H1H_RS04995	COG0066	3-isopropylmalate dehydratase activity
A7H1H_RS05000	COG0473	3-isopropylmalate dehydrogenase activity
A7H1H_RS05015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7H1H_RS05020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7H1H_RS05025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7H1H_RS05030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7H1H_RS05035	COG0202	RNA polymerase activity
A7H1H_RS05040	COG0203	ribosomal protein L17
A7H1H_RS05045	COG0154	amidase activity
A7H1H_RS05050	COG0516	GMP reductase activity
A7H1H_RS05050	COG0517	IMP dehydrogenase activity
A7H1H_RS05065	COG0484	heat shock protein binding
A7H1H_RS05080	COG1119	ATPase activity
A7H1H_RS05105	COG1733	regulation of RNA biosynthetic process
A7H1H_RS05110	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7H1H_RS05120	COG2076	Multidrug Resistance protein
A7H1H_RS05140	COG0583	DNA-binding transcription factor activity
A7H1H_RS05145	COG2855	membrane
A7H1H_RS05175	COG1733	regulation of RNA biosynthetic process
A7H1H_RS05180	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7H1H_RS05200	COG0778	Nitroreductase
A7H1H_RS05210	COG0488	(ABC) transporter
A7H1H_RS05215	COG1607	acyl-coa hydrolase
A7H1H_RS05225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7H1H_RS05230	COG0754	glutathionylspermidine amidase activity
A7H1H_RS05250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7H1H_RS05260	COG1496	oxidoreductase activity
A7H1H_RS05265	COG0280	phosphate acetyltransferase
A7H1H_RS05265	COG0281	malic enzyme
A7H1H_RS05270	COG0788	formyltetrahydrofolate deformylase activity
A7H1H_RS05275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7H1H_RS05300	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS05310	COG0330	HflC and HflK could
A7H1H_RS05330	COG1271	oxidase subunit
A7H1H_RS05360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7H1H_RS05370	COG0546	phosphoglycolate phosphatase activity
A7H1H_RS05380	COG1696	Membrane protein involved in D-alanine export
A7H1H_RS05410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A7H1H_RS05420	COG0406	alpha-ribazole phosphatase activity
A7H1H_RS05425	COG1132	(ABC) transporter
A7H1H_RS05435	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS05440	COG0642	Histidine kinase
A7H1H_RS05465	COG0513	Belongs to the DEAD box helicase family
A7H1H_RS05475	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS05510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7H1H_RS05520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7H1H_RS05525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7H1H_RS05535	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7H1H_RS05540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7H1H_RS05560	COG0488	(ABC) transporter
A7H1H_RS05575	COG0243	molybdopterin cofactor binding
A7H1H_RS05585	COG1193	negative regulation of DNA recombination
A7H1H_RS05590	COG1253	flavin adenine dinucleotide binding
A7H1H_RS05600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7H1H_RS05605	COG0004	ammonium transporteR
A7H1H_RS05620	COG0248	Ppx GppA phosphatase
A7H1H_RS05630	COG0028	Belongs to the TPP enzyme family
A7H1H_RS05635	COG0440	acetolactate synthase activity
A7H1H_RS05640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7H1H_RS05645	COG1196	nuclear chromosome segregation
A7H1H_RS05645	COG1674	ftsk spoiiie
A7H1H_RS05650	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS05655	COG0642	Histidine kinase
A7H1H_RS05745	COG3012	SEC-C Motif Domain Protein
A7H1H_RS05750	COG0420	3'-5' exonuclease activity
A7H1H_RS05755	COG0419	ATPase involved in DNA repair
A7H1H_RS05780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A7H1H_RS05795	COG1160	GTP binding
A7H1H_RS05800	COG0659	secondary active sulfate transmembrane transporter activity
A7H1H_RS05820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7H1H_RS05830	COG1185	polyribonucleotide nucleotidyltransferase activity
A7H1H_RS05840	COG2198	Histidine kinase
A7H1H_RS05840	COG0643	Histidine kinase
A7H1H_RS05845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7H1H_RS05850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A7H1H_RS05855	COG2201	protein-glutamate methylesterase activity
A7H1H_RS05865	COG2223	nitrite transmembrane transporter activity
A7H1H_RS05870	COG0582	viral genome integration into host DNA
A7H1H_RS05890	COG0339	signal peptide processing
A7H1H_RS05895	COG2890	protein-(glutamine-N5) methyltransferase activity
A7H1H_RS05900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7H1H_RS05905	COG0494	nUDIX hydrolase
A7H1H_RS05910	COG0527	aspartate kinase activity
A7H1H_RS05925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7H1H_RS05935	COG0287	Prephenate dehydrogenase
A7H1H_RS05940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7H1H_RS05945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7H1H_RS05950	COG0612	Peptidase, M16
A7H1H_RS05955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7H1H_RS05980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7H1H_RS05990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7H1H_RS05990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7H1H_RS06015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7H1H_RS06040	COG0751	glycine-tRNA ligase activity
A7H1H_RS06055	COG0357	Ribosomal RNA small subunit methyltransferase G
A7H1H_RS06060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7H1H_RS06065	COG0113	porphobilinogen synthase activity
A7H1H_RS06070	COG0784	Response regulator, receiver
A7H1H_RS06070	COG4191	Histidine kinase
A7H1H_RS06075	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS06085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7H1H_RS06085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7H1H_RS06090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7H1H_RS06095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7H1H_RS06115	COG1663	tetraacyldisaccharide 4'-kinase activity
A7H1H_RS06125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7H1H_RS06145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7H1H_RS06150	COG0805	protein transport
A7H1H_RS06155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7H1H_RS06160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7H1H_RS06165	COG4206	TonB-dependent receptor
A7H1H_RS06180	COG3328	transposase activity
A7H1H_RS06205	COG2181	nitrate reductase activity
A7H1H_RS06205	COG0247	lactate metabolic process
A7H1H_RS06210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7H1H_RS06230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A7H1H_RS06235	COG2199	diguanylate cyclase activity
A7H1H_RS06235	COG3287	FIST C domain
A7H1H_RS06235	COG2200	EAL domain
A7H1H_RS06240	COG1137	ATPase activity
A7H1H_RS06245	COG0802	atpase or kinase
A7H1H_RS06250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7H1H_RS06265	COG0137	argininosuccinate synthase activity
A7H1H_RS06270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7H1H_RS06275	COG1696	Membrane protein involved in D-alanine export
A7H1H_RS06285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7H1H_RS06295	COG0569	domain protein
A7H1H_RS06300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7H1H_RS06305	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS06310	COG2205	protein histidine kinase activity
A7H1H_RS06325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7H1H_RS06330	COG0484	heat shock protein binding
A7H1H_RS06335	COG0133	tryptophan synthase activity
A7H1H_RS06355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7H1H_RS06365	COG2199	diguanylate cyclase activity
A7H1H_RS06370	COG0500	methyltransferase
A7H1H_RS06380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7H1H_RS06380	COG1333	cytochrome c biogenesis protein
A7H1H_RS06385	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7H1H_RS06395	COG0840	transmembrane signaling receptor activity
A7H1H_RS06405	COG0653	protein targeting
A7H1H_RS06410	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7H1H_RS06430	COG0039	L-malate dehydrogenase activity
A7H1H_RS06455	COG0275	rRNA processing
A7H1H_RS06465	COG0776	regulation of translation
A7H1H_RS06480	COG3328	transposase activity
A7H1H_RS06535	COG1802	Transcriptional regulator
A7H1H_RS06535	COG4626	Terminase
A7H1H_RS06560	COG1401	restriction endodeoxyribonuclease activity
A7H1H_RS06570	COG0270	DNA (cytosine-5-)-methyltransferase activity
A7H1H_RS06585	COG2026	Addiction module toxin, RelE StbE family
A7H1H_RS06595	COG4974	Belongs to the 'phage' integrase family
A7H1H_RS06605	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7H1H_RS06615	COG1959	2 iron, 2 sulfur cluster binding
A7H1H_RS06630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7H1H_RS06630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7H1H_RS06640	COG2201	protein-glutamate methylesterase activity
A7H1H_RS06655	COG0484	heat shock protein binding
A7H1H_RS06660	COG0789	Transcriptional regulator
A7H1H_RS06670	COG1131	(ABC) transporter
A7H1H_RS06675	COG0842	Transport permease protein
A7H1H_RS06680	COG0842	Transport permease protein
A7H1H_RS06685	COG0861	Integral membrane protein TerC family
A7H1H_RS06690	COG1114	Component of the transport system for branched-chain amino acids
A7H1H_RS06700	COG0582	viral genome integration into host DNA
A7H1H_RS06790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7H1H_RS06800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7H1H_RS06810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7H1H_RS06820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7H1H_RS06860	COG0488	(ABC) transporter
A7H1H_RS06865	COG2171	N-acyltransferase activity
A7H1H_RS06870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7H1H_RS06880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7H1H_RS06910	COG0309	Hydrogenase expression formation protein (HypE)
A7H1H_RS06920	COG2084	Dehydrogenase
A7H1H_RS06925	COG0409	Hydrogenase expression formation protein
A7H1H_RS06930	COG0298	carbon dioxide binding
A7H1H_RS06935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7H1H_RS06945	COG0840	transmembrane signaling receptor activity
A7H1H_RS06950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7H1H_RS06960	COG2081	HI0933 family
A7H1H_RS06980	COG0439	Biotin carboxylase
A7H1H_RS07010	COG2354	Protein conserved in bacteria
A7H1H_RS07020	COG2814	Major facilitator Superfamily
A7H1H_RS07030	COG0301	tRNA thio-modification
A7H1H_RS07030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7H1H_RS07050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A7H1H_RS07055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A7H1H_RS07060	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A7H1H_RS07065	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A7H1H_RS07070	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A7H1H_RS07075	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A7H1H_RS07080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A7H1H_RS07095	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A7H1H_RS07100	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A7H1H_RS07115	COG1309	transcriptional regulator
A7H1H_RS07120	COG1049	propionate catabolic process, 2-methylcitrate cycle
A7H1H_RS07130	COG5001	Diguanylate cyclase
A7H1H_RS07130	COG2203	Gaf domain
A7H1H_RS07130	COG3706	GGDEF domain
A7H1H_RS07130	COG4251	negative regulation of phosphorylation
A7H1H_RS07135	COG0217	transcriptional regulatory protein
A7H1H_RS07140	COG2853	Lipoprotein
A7H1H_RS07155	COG1611	Belongs to the LOG family
A7H1H_RS07160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7H1H_RS07175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7H1H_RS07195	COG4773	Receptor
A7H1H_RS07210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7H1H_RS07225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7H1H_RS07250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7H1H_RS07255	COG2258	MOSC domain
A7H1H_RS07260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7H1H_RS07265	COG0095	Lipoate-protein ligase
A7H1H_RS07270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7H1H_RS07275	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7H1H_RS07280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7H1H_RS07285	COG1492	cobalamin metabolic process
A7H1H_RS07290	COG4773	Receptor
A7H1H_RS07305	COG0513	Belongs to the DEAD box helicase family
A7H1H_RS07330	COG1944	ATP diphosphatase activity
A7H1H_RS07345	COG0840	transmembrane signaling receptor activity
A7H1H_RS07350	COG0328	RNA-DNA hybrid ribonuclease activity
A7H1H_RS07355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7H1H_RS07380	COG0303	'Molybdopterin
A7H1H_RS07390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7H1H_RS07400	COG0437	4 iron, 4 sulfur cluster binding
A7H1H_RS07460	COG1305	Transglutaminase-like
A7H1H_RS07470	COG0437	4 iron, 4 sulfur cluster binding
A7H1H_RS07475	COG0243	molybdopterin cofactor binding
A7H1H_RS07475	COG3383	formate dehydrogenase (NAD+) activity
A7H1H_RS07485	COG0709	Synthesizes selenophosphate from selenide and ATP
A7H1H_RS07500	COG1921	L-seryl-tRNASec selenium transferase activity
A7H1H_RS07565	COG1078	dGTPase activity
A7H1H_RS07570	COG5002	protein histidine kinase activity
A7H1H_RS07570	COG5001	Diguanylate cyclase
A7H1H_RS07575	COG0259	pyridoxamine-phosphate oxidase activity
A7H1H_RS07585	COG0513	Belongs to the DEAD box helicase family
A7H1H_RS07605	COG0326	Molecular chaperone. Has ATPase activity
A7H1H_RS07610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7H1H_RS07630	COG2995	paraquat-inducible protein a
A7H1H_RS07645	COG5001	Diguanylate cyclase
A7H1H_RS07645	COG5002	protein histidine kinase activity
A7H1H_RS07675	COG4335	DNA alkylation repair
A7H1H_RS07680	COG2329	Antibiotic biosynthesis monooxygenase
A7H1H_RS07710	COG1595	DNA-templated transcription, initiation
A7H1H_RS07715	COG0010	Belongs to the arginase family
A7H1H_RS07720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7H1H_RS07725	COG2207	Transcriptional regulator
A7H1H_RS07735	COG0326	Molecular chaperone. Has ATPase activity
A7H1H_RS07745	COG4771	TonB-dependent receptor
A7H1H_RS07750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7H1H_RS07755	COG0668	transmembrane transport
A7H1H_RS07760	COG1227	inorganic diphosphatase activity
A7H1H_RS07775	COG1027	Aspartate ammonia-lyase
A7H1H_RS07780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7H1H_RS07785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7H1H_RS07790	COG1047	Peptidyl-prolyl cis-trans
A7H1H_RS07805	COG0823	Involved in the tonB-independent uptake of proteins
A7H1H_RS07815	COG0848	biopolymer transport protein
A7H1H_RS07820	COG0811	peptide transport
A7H1H_RS07825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7H1H_RS07830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7H1H_RS07835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7H1H_RS07840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7H1H_RS07845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7H1H_RS07850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7H1H_RS07860	COG1475	DNA binding
A7H1H_RS07865	COG1192	Involved in chromosome partitioning
A7H1H_RS07880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7H1H_RS07885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7H1H_RS07890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7H1H_RS07895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7H1H_RS07900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7H1H_RS07905	COG0358	DNA primase activity
A7H1H_RS07915	COG0571	ribonuclease III activity
A7H1H_RS07920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7H1H_RS07930	COG0501	Belongs to the peptidase M48B family
A7H1H_RS07950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7H1H_RS07960	COG0706	membrane insertase activity
A7H1H_RS07965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7H1H_RS07975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7H1H_RS07980	COG0542	response to heat
A7H1H_RS07985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7H1H_RS07995	COG2326	polyphosphate kinase activity
A7H1H_RS08005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7H1H_RS08010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7H1H_RS08015	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7H1H_RS08040	COG0138	bifunctional purine biosynthesis protein purh
A7H1H_RS08045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7H1H_RS08055	COG0739	heme binding
A7H1H_RS08060	COG0302	gtp cyclohydrolase
A7H1H_RS08065	COG0598	Magnesium transport protein CorA
A7H1H_RS08090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7H1H_RS08095	COG0606	chelatase, subunit chli
A7H1H_RS08115	COG0242	peptide deformylase activity
A7H1H_RS08120	COG0740	serine-type endopeptidase activity
A7H1H_RS08125	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7H1H_RS08160	COG0626	cystathionine gamma-synthase activity
A7H1H_RS08195	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS08205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A7H1H_RS08220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7H1H_RS08225	COG1858	cytochrome C peroxidase
A7H1H_RS08255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7H1H_RS08280	COG0351	phosphomethylpyrimidine kinase
A7H1H_RS08285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7H1H_RS08300	COG0348	domain, Protein
A7H1H_RS08320	COG2207	Transcriptional regulator
A7H1H_RS08320	COG4753	response regulator
A7H1H_RS08330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7H1H_RS08335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7H1H_RS08355	COG0716	FMN binding
A7H1H_RS08370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A7H1H_RS08375	COG0159	tryptophan synthase activity
A7H1H_RS08380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7H1H_RS08385	COG2255	four-way junction helicase activity
A7H1H_RS08390	COG0628	permease
A7H1H_RS08430	COG0731	radical SAM domain protein
A7H1H_RS08435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7H1H_RS08445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7H1H_RS08460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7H1H_RS08470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7H1H_RS08480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7H1H_RS08490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7H1H_RS08490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7H1H_RS08495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7H1H_RS08500	COG3328	transposase activity
A7H1H_RS08505	COG1368	sulfuric ester hydrolase activity
A7H1H_RS08510	COG0859	PFAM glycosyl transferase family 9
A7H1H_RS08530	COG0859	PFAM glycosyl transferase family 9
A7H1H_RS08535	COG0859	PFAM glycosyl transferase family 9
A7H1H_RS08545	COG0463	Glycosyl transferase, family 2
A7H1H_RS08550	COG1083	cytidylyl-transferase
A7H1H_RS08550	COG2755	lipolytic protein G-D-S-L family
A7H1H_RS08560	COG2089	acid synthase
A7H1H_RS08570	COG0438	transferase activity, transferring glycosyl groups
A7H1H_RS08590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7H1H_RS08605	COG0859	PFAM glycosyl transferase family 9
A7H1H_RS08615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7H1H_RS08625	COG0493	'glutamate synthase
A7H1H_RS08630	COG0067	glutamate synthase
A7H1H_RS08630	COG0069	glutamate synthase activity
A7H1H_RS08630	COG0070	glutamate synthase
A7H1H_RS08645	COG0840	transmembrane signaling receptor activity
A7H1H_RS08655	COG1739	Uncharacterized protein family UPF0029
A7H1H_RS08665	COG0196	riboflavin kinase activity
A7H1H_RS08670	COG2226	methyltransferase
A7H1H_RS08675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7H1H_RS08685	COG0277	FAD linked oxidase domain protein
A7H1H_RS08690	COG1295	ribonuclease BN
A7H1H_RS08700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7H1H_RS08710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A7H1H_RS08720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7H1H_RS08725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7H1H_RS08730	COG0284	orotidine-5'-phosphate decarboxylase activity
A7H1H_RS08755	COG1918	ferrous iron import across plasma membrane
A7H1H_RS08760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A7H1H_RS08760	COG1918	ferrous iron import across plasma membrane
A7H1H_RS08785	COG2217	Heavy metal translocating P-type atpase
A7H1H_RS08790	COG0640	Transcriptional regulator
A7H1H_RS08795	COG4773	Receptor
A7H1H_RS08805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7H1H_RS08820	COG1278	Cold shock
A7H1H_RS08825	COG4753	response regulator
A7H1H_RS08825	COG2207	Transcriptional regulator
A7H1H_RS08830	COG3852	Histidine kinase
A7H1H_RS08860	COG0450	alkyl hydroperoxide reductase
A7H1H_RS08865	COG3118	belongs to the thioredoxin family
A7H1H_RS08880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7H1H_RS08885	COG0085	RNA polymerase activity
A7H1H_RS08890	COG0222	ribosome binding
A7H1H_RS08895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7H1H_RS08900	COG0081	regulation of translation
A7H1H_RS08905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7H1H_RS08910	COG0250	Participates in transcription elongation, termination and antitermination
A7H1H_RS08925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7H1H_RS08930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7H1H_RS08960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7H1H_RS08965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A7H1H_RS08970	COG0444	Belongs to the ABC transporter superfamily
A7H1H_RS08975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7H1H_RS08985	COG1696	Membrane protein involved in D-alanine export
A7H1H_RS08990	COG0174	glutamine synthetase
A7H1H_RS09000	COG0314	molybdopterin synthase activity
A7H1H_RS09010	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7H1H_RS09015	COG1968	undecaprenyl-diphosphatase activity
A7H1H_RS09020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7H1H_RS09025	COG0772	Belongs to the SEDS family
A7H1H_RS09035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7H1H_RS09080	COG0542	response to heat
A7H1H_RS09085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7H1H_RS09090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7H1H_RS09105	COG2030	dehydratase
A7H1H_RS09125	COG0840	transmembrane signaling receptor activity
A7H1H_RS09130	COG1970	mechanosensitive ion channel activity
A7H1H_RS09135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A7H1H_RS09155	COG2059	Chromate
A7H1H_RS09160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7H1H_RS09165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7H1H_RS09175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7H1H_RS09180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7H1H_RS09185	COG1157	protein secretion by the type III secretion system
A7H1H_RS09195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7H1H_RS09215	COG1677	Flagellar hook-basal body complex protein FliE
A7H1H_RS09225	COG0455	bacterial-type flagellum organization
A7H1H_RS09230	COG1419	protein localization to endoplasmic reticulum
A7H1H_RS09245	COG3951	Flagellar rod assembly protein muramidase FlgJ
A7H1H_RS09250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7H1H_RS09270	COG1749	Flagellar hook protein flgE
A7H1H_RS09275	COG4786	Flagellar basal body rod
A7H1H_RS09285	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7H1H_RS09295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7H1H_RS09300	COG1766	The M ring may be actively involved in energy transduction
A7H1H_RS09305	COG1815	bacterial-type flagellum-dependent cell motility
A7H1H_RS09310	COG4786	Flagellar basal body rod
A7H1H_RS09320	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS09340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7H1H_RS09350	COG0228	four-way junction DNA binding
A7H1H_RS09355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7H1H_RS09360	COG0564	pseudouridine synthase activity
A7H1H_RS09365	COG1519	Transferase
A7H1H_RS09375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7H1H_RS09380	COG0752	glycyl-tRNA synthetase alpha subunit
A7H1H_RS09390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7H1H_RS09400	COG0826	peptidase U32
A7H1H_RS09405	COG0840	transmembrane signaling receptor activity
A7H1H_RS09410	COG0497	DNA recombination
A7H1H_RS09415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7H1H_RS09420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7H1H_RS09425	COG0049	tRNA binding
A7H1H_RS09430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7H1H_RS09440	COG2814	Major facilitator Superfamily
A7H1H_RS09445	COG4771	TonB-dependent receptor
A7H1H_RS09460	COG1116	anion transmembrane transporter activity
A7H1H_RS09465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7H1H_RS09505	COG0512	Glutamine amidotransferase of anthranilate synthase
A7H1H_RS09510	COG1840	ABC-type Fe3 transport system, periplasmic component
A7H1H_RS09515	COG1178	ABC-type Fe3 transport system permease component
A7H1H_RS09530	COG4774	siderophore transport
A7H1H_RS09570	COG2183	response to ionizing radiation
A7H1H_RS09580	COG0251	oxidation-reduction process
A7H1H_RS09595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7H1H_RS09605	COG0586	Pfam SNARE associated Golgi protein
A7H1H_RS09610	COG0335	large ribosomal subunit rRNA binding
A7H1H_RS09615	COG0336	Belongs to the RNA methyltransferase TrmD family
A7H1H_RS09625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7H1H_RS09630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7H1H_RS09635	COG0356	it plays a direct role in the translocation of protons across the membrane
A7H1H_RS09645	COG4773	Receptor
A7H1H_RS09655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7H1H_RS09665	COG0157	Belongs to the NadC ModD family
A7H1H_RS09680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7H1H_RS09690	COG0083	homoserine kinase activity
A7H1H_RS09700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7H1H_RS09705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7H1H_RS09710	COG0779	Required for maturation of 30S ribosomal subunits
A7H1H_RS09715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7H1H_RS09715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7H1H_RS09720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7H1H_RS09725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7H1H_RS09730	COG0539	negative regulation of cytoplasmic translation
A7H1H_RS09730	COG1185	polyribonucleotide nucleotidyltransferase activity
A7H1H_RS09735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7H1H_RS09740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7H1H_RS09745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7H1H_RS09745	COG0072	phenylalanine-tRNA ligase activity
A7H1H_RS09750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7H1H_RS09755	COG0537	adenosine 5'-monophosphoramidase activity
A7H1H_RS09760	COG0825	malonyl-CoA metabolic process
A7H1H_RS09765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7H1H_RS09770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7H1H_RS09780	COG0602	queuosine metabolic process
A7H1H_RS09790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7H1H_RS09800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7H1H_RS09815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A7H1H_RS09825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A7H1H_RS09830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7H1H_RS09835	COG1074	ATP-dependent DNA helicase activity
A7H1H_RS09845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7H1H_RS09850	COG3328	transposase activity
A7H1H_RS09895	COG3278	Belongs to the heme-copper respiratory oxidase family
A7H1H_RS09900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7H1H_RS09905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7H1H_RS09910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7H1H_RS09915	COG0210	DNA helicase
A7H1H_RS09925	COG1242	4 iron, 4 sulfur cluster binding
A7H1H_RS09930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7H1H_RS09935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7H1H_RS09940	COG0492	ferredoxin-NADP+ reductase activity
A7H1H_RS09945	COG3118	belongs to the thioredoxin family
A7H1H_RS09950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7H1H_RS09975	COG0642	Histidine kinase
A7H1H_RS09980	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS09990	COG0129	dihydroxy-acid dehydratase activity
A7H1H_RS10020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7H1H_RS10035	COG0585	pseudouridine synthase activity
A7H1H_RS10050	COG0793	Belongs to the peptidase S41A family
A7H1H_RS10055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7H1H_RS10060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7H1H_RS10065	COG0047	phosphoribosylformylglycinamidine synthase activity
A7H1H_RS10075	COG0204	Acyl-transferase
A7H1H_RS10080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7H1H_RS10085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7H1H_RS10090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7H1H_RS10095	COG0018	arginyl-trna synthetase
A7H1H_RS10105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7H1H_RS10115	COG0126	phosphoglycerate kinase activity
A7H1H_RS10120	COG0149	triose-phosphate isomerase activity
A7H1H_RS10125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7H1H_RS10130	COG0019	diaminopimelate decarboxylase activity
A7H1H_RS10135	COG1605	Chorismate mutase
A7H1H_RS10135	COG0077	Prephenate dehydratase
A7H1H_RS10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7H1H_RS10145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7H1H_RS10155	COG0424	maF-like protein
A7H1H_RS10170	COG0791	NLP P60 protein
A7H1H_RS10185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7H1H_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
A7H1H_RS10200	COG1704	LemA family
A7H1H_RS10215	COG0546	phosphoglycolate phosphatase activity
A7H1H_RS10220	COG0783	Belongs to the Dps family
A7H1H_RS10225	COG2814	Major facilitator Superfamily
A7H1H_RS10245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7H1H_RS10270	COG1595	DNA-templated transcription, initiation
A7H1H_RS10290	COG2081	HI0933 family
A7H1H_RS10305	COG1959	2 iron, 2 sulfur cluster binding
A7H1H_RS10320	COG0175	sulfate reduction
A7H1H_RS10325	COG0175	sulfate reduction
A7H1H_RS10330	COG2895	sulfate adenylyltransferase (ATP) activity
A7H1H_RS10345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7H1H_RS10375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7H1H_RS10390	COG4232	protein-disulfide reductase activity
A7H1H_RS10395	COG0189	ligase activity
A7H1H_RS10410	COG2199	diguanylate cyclase activity
A7H1H_RS10410	COG3287	FIST C domain
A7H1H_RS10410	COG2200	EAL domain
A7H1H_RS10415	COG0688	phosphatidylethanolamine metabolic process
A7H1H_RS10425	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A7H1H_RS10430	COG0443	Heat shock 70 kDa protein
A7H1H_RS10435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7H1H_RS10450	COG0101	tRNA pseudouridine synthase activity
A7H1H_RS10465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7H1H_RS10470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7H1H_RS10475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7H1H_RS10490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7H1H_RS10495	COG0494	nUDIX hydrolase
A7H1H_RS10555	COG0445	tRNA wobble uridine modification
A7H1H_RS10575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7H1H_RS10580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7H1H_RS10585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7H1H_RS10595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7H1H_RS10620	COG1252	NADH dehydrogenase
A7H1H_RS10625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7H1H_RS10635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7H1H_RS10640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7H1H_RS10650	COG2814	Major facilitator Superfamily
A7H1H_RS10655	COG0659	secondary active sulfate transmembrane transporter activity
A7H1H_RS10675	COG1222	aaa ATPase
A7H1H_RS10685	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7H1H_RS10690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7H1H_RS10705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7H1H_RS10720	COG0148	phosphopyruvate hydratase activity
A7H1H_RS10725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7H1H_RS10735	COG1086	Polysaccharide biosynthesis protein
A7H1H_RS10740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7H1H_RS10745	COG1083	cytidylyl-transferase
A7H1H_RS10755	COG2089	acid synthase
A7H1H_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
A7H1H_RS10795	COG1216	Glycosyl transferase, family 2
A7H1H_RS10870	COG0348	domain, Protein
A7H1H_RS10875	COG0504	CTP synthase activity
A7H1H_RS10880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7H1H_RS10900	COG0587	DNA-directed DNA polymerase activity
A7H1H_RS10905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7H1H_RS10915	COG3328	transposase activity
A7H1H_RS10925	COG0315	cyclic pyranopterin monophosphate synthase activity
A7H1H_RS10930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A7H1H_RS10965	COG0670	Belongs to the BI1 family
A7H1H_RS10970	COG0352	thiamine-phosphate diphosphorylase activity
A7H1H_RS10980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7H1H_RS10985	COG0233	cytoplasmic translational termination
A7H1H_RS10990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7H1H_RS11015	COG3022	response to hydroperoxide
A7H1H_RS11030	COG1408	metallophosphoesterase
A7H1H_RS11040	COG4771	TonB-dependent receptor
A7H1H_RS11045	COG2207	Transcriptional regulator
A7H1H_RS11045	COG1609	Transcriptional regulator
A7H1H_RS11050	COG0071	Belongs to the small heat shock protein (HSP20) family
A7H1H_RS11055	COG2703	oxygen carrier activity
A7H1H_RS11060	COG0840	transmembrane signaling receptor activity
A7H1H_RS11080	COG1305	Transglutaminase-like
A7H1H_RS11090	COG4208	sulfate ABC transporter
A7H1H_RS11095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A7H1H_RS11105	COG2200	EAL domain
A7H1H_RS11105	COG3287	FIST C domain
A7H1H_RS11105	COG2199	diguanylate cyclase activity
A7H1H_RS11130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7H1H_RS11145	COG1116	anion transmembrane transporter activity
A7H1H_RS11150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7H1H_RS11155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7H1H_RS11160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7H1H_RS11185	COG2308	Evidence 4 Homologs of previously reported genes of
A7H1H_RS11190	COG1217	gtp-binding protein TYPA
A7H1H_RS11195	COG2391	methyltransferase activity
A7H1H_RS11200	COG0425	Belongs to the sulfur carrier protein TusA family
A7H1H_RS11205	COG3706	GGDEF domain
A7H1H_RS11245	COG0745	RESPONSE REGULATOR receiver
A7H1H_RS11250	COG2205	protein histidine kinase activity
A7H1H_RS11250	COG2770	Histidine kinase
A7H1H_RS11255	COG2226	methyltransferase
A7H1H_RS11260	COG2207	Transcriptional regulator
A7H1H_RS11270	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A7H1H_RS11290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7H1H_RS11320	COG1045	serine acetyltransferase
A7H1H_RS11335	COG4735	regulation of single-species biofilm formation
A7H1H_RS11345	COG2207	Transcriptional regulator
A7H1H_RS11345	COG1609	Transcriptional regulator
A7H1H_RS11370	COG1442	glycosyl transferase family 8
A7H1H_RS11370	COG1216	Glycosyl transferase, family 2
A7H1H_RS11395	COG0594	ribonuclease P activity
A7H1H_RS11400	COG0840	transmembrane signaling receptor activity
A7H1H_RS11415	COG2205	protein histidine kinase activity
A7H1H_RS11475	COG0454	-acetyltransferase
A7H1H_RS11540	COG2608	mercury ion transmembrane transporter activity