locus-tag	class	description
HOO34_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HOO34_RS00010	COG0592	DNA-directed DNA polymerase activity
HOO34_RS00015	COG0187	DNA topoisomerase II activity
HOO34_RS00020	COG0492	ferredoxin-NADP+ reductase activity
HOO34_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HOO34_RS00050	COG0500	methyltransferase
HOO34_RS00060	COG1120	ATPase activity
HOO34_RS00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOO34_RS00075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOO34_RS00085	COG3842	ATPase activity
HOO34_RS00145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO34_RS00155	COG0840	transmembrane signaling receptor activity
HOO34_RS00160	COG0840	transmembrane signaling receptor activity
HOO34_RS00165	COG2081	HI0933 family
HOO34_RS00195	COG1959	2 iron, 2 sulfur cluster binding
HOO34_RS00210	COG0175	sulfate reduction
HOO34_RS00215	COG0175	sulfate reduction
HOO34_RS00220	COG2895	sulfate adenylyltransferase (ATP) activity
HOO34_RS00230	COG2814	Major facilitator Superfamily
HOO34_RS00235	COG0783	Belongs to the Dps family
HOO34_RS00240	COG0546	phosphoglycolate phosphatase activity
HOO34_RS00250	COG1012	belongs to the aldehyde dehydrogenase family
HOO34_RS00255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOO34_RS00270	COG3022	response to hydroperoxide
HOO34_RS00290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOO34_RS00295	COG0233	cytoplasmic translational termination
HOO34_RS00300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HOO34_RS00310	COG0352	thiamine-phosphate diphosphorylase activity
HOO34_RS00315	COG0670	Belongs to the BI1 family
HOO34_RS00355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HOO34_RS00360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO34_RS00365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HOO34_RS00370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO34_RS00375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HOO34_RS00380	COG1077	Cell shape determining protein MreB Mrl
HOO34_RS00395	COG0445	tRNA wobble uridine modification
HOO34_RS00455	COG1484	DNA-dependent DNA replication
HOO34_RS00465	COG4584	PFAM Integrase catalytic
HOO34_RS00480	COG1484	DNA-dependent DNA replication
HOO34_RS00525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HOO34_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
HOO34_RS00535	COG0659	secondary active sulfate transmembrane transporter activity
HOO34_RS00550	COG1222	aaa ATPase
HOO34_RS00560	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOO34_RS00565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HOO34_RS00575	COG3077	Addiction module antitoxin, RelB DinJ family
HOO34_RS00595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HOO34_RS00600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOO34_RS00610	COG1086	Polysaccharide biosynthesis protein
HOO34_RS00615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO34_RS00625	COG1083	cytidylyl-transferase
HOO34_RS00630	COG2089	acid synthase
HOO34_RS00655	COG0028	Belongs to the TPP enzyme family
HOO34_RS00660	COG0028	Belongs to the TPP enzyme family
HOO34_RS00665	COG1028	Short-chain dehydrogenase reductase Sdr
HOO34_RS00675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOO34_RS00680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HOO34_RS00690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HOO34_RS00730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOO34_RS00745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HOO34_RS00755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOO34_RS00760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HOO34_RS00765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOO34_RS00790	COG1420	regulation of RNA biosynthetic process
HOO34_RS00795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOO34_RS00800	COG0443	Heat shock 70 kDa protein
HOO34_RS00820	COG2121	Domain of unknown function (DUF374)
HOO34_RS00825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO34_RS00835	COG0195	Participates in both transcription termination and antitermination
HOO34_RS00840	COG0215	cysteine-tRNA ligase activity
HOO34_RS00845	COG1002	Type II restriction enzyme, methylase subunits
HOO34_RS00860	COG1393	Belongs to the ArsC family
HOO34_RS00865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOO34_RS00870	COG0343	queuine tRNA-ribosyltransferase activity
HOO34_RS00900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOO34_RS00905	COG0557	exoribonuclease II activity
HOO34_RS00915	COG1466	dna polymerase III delta subunit
HOO34_RS00920	COG0360	Binds together with S18 to 16S ribosomal RNA
HOO34_RS00925	COG0629	single-stranded DNA binding
HOO34_RS00930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOO34_RS00940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HOO34_RS00955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HOO34_RS00965	COG0157	Belongs to the NadC ModD family
HOO34_RS00980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HOO34_RS00990	COG0083	homoserine kinase activity
HOO34_RS01000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HOO34_RS01005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HOO34_RS01010	COG0779	Required for maturation of 30S ribosomal subunits
HOO34_RS01015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO34_RS01015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO34_RS01045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOO34_RS01050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOO34_RS01055	COG1185	polyribonucleotide nucleotidyltransferase activity
HOO34_RS01055	COG0539	negative regulation of cytoplasmic translation
HOO34_RS01060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HOO34_RS01065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HOO34_RS01070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO34_RS01070	COG0072	phenylalanine-tRNA ligase activity
HOO34_RS01075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HOO34_RS01080	COG0537	adenosine 5'-monophosphoramidase activity
HOO34_RS01085	COG0825	malonyl-CoA metabolic process
HOO34_RS01090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO34_RS01095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO34_RS01105	COG0602	queuosine metabolic process
HOO34_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HOO34_RS01135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HOO34_RS01145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HOO34_RS01150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HOO34_RS01165	COG0356	it plays a direct role in the translocation of protons across the membrane
HOO34_RS01170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HOO34_RS01175	COG0191	fructose-bisphosphate aldolase activity
HOO34_RS01185	COG0745	RESPONSE REGULATOR receiver
HOO34_RS01190	COG0642	Histidine kinase
HOO34_RS01225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOO34_RS01235	COG2200	EAL domain
HOO34_RS01235	COG3287	FIST C domain
HOO34_RS01235	COG2199	diguanylate cyclase activity
HOO34_RS01255	COG3043	anaerobic respiration
HOO34_RS01260	COG0348	domain, Protein
HOO34_RS01265	COG0437	4 iron, 4 sulfur cluster binding
HOO34_RS01270	COG0243	molybdopterin cofactor binding
HOO34_RS01285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO34_RS01290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HOO34_RS01295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HOO34_RS01305	COG2404	hydrolase activity, acting on ester bonds
HOO34_RS01325	COG0840	transmembrane signaling receptor activity
HOO34_RS01350	COG2030	dehydratase
HOO34_RS01370	COG1401	restriction endodeoxyribonuclease activity
HOO34_RS01380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HOO34_RS01385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HOO34_RS01390	COG0542	response to heat
HOO34_RS01425	COG0148	phosphopyruvate hydratase activity
HOO34_RS01440	COG2814	Major facilitator Superfamily
HOO34_RS01450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HOO34_RS01455	COG0049	tRNA binding
HOO34_RS01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOO34_RS01465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HOO34_RS01470	COG0497	DNA recombination
HOO34_RS01475	COG0840	transmembrane signaling receptor activity
HOO34_RS01475	COG0840	transmembrane signaling receptor activity
HOO34_RS01480	COG0826	peptidase U32
HOO34_RS01490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HOO34_RS01500	COG0752	glycyl-tRNA synthetase alpha subunit
HOO34_RS01505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HOO34_RS01515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOO34_RS01515	COG1519	Transferase
HOO34_RS01520	COG0564	pseudouridine synthase activity
HOO34_RS01525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HOO34_RS01530	COG0228	four-way junction DNA binding
HOO34_RS01535	COG1837	Belongs to the UPF0109 family
HOO34_RS01540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOO34_RS01560	COG0745	RESPONSE REGULATOR receiver
HOO34_RS01570	COG4786	Flagellar basal body rod
HOO34_RS01575	COG1815	bacterial-type flagellum-dependent cell motility
HOO34_RS01580	COG1766	The M ring may be actively involved in energy transduction
HOO34_RS01585	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HOO34_RS01595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HOO34_RS01605	COG1749	Flagellar hook protein flgE
HOO34_RS01635	COG3951	Flagellar rod assembly protein muramidase FlgJ
HOO34_RS01650	COG1419	protein localization to endoplasmic reticulum
HOO34_RS01655	COG0455	bacterial-type flagellum organization
HOO34_RS01685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO34_RS01695	COG1157	protein secretion by the type III secretion system
HOO34_RS01705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO34_RS01715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOO34_RS01730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOO34_RS01740	COG0336	Belongs to the RNA methyltransferase TrmD family
HOO34_RS01745	COG0335	large ribosomal subunit rRNA binding
HOO34_RS01750	COG0586	Pfam SNARE associated Golgi protein
HOO34_RS01755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOO34_RS01795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HOO34_RS01805	COG0582	viral genome integration into host DNA
HOO34_RS01885	COG0582	viral genome integration into host DNA
HOO34_RS01890	COG3657	addiction module killer protein
HOO34_RS01895	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOO34_RS01995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO34_RS02005	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HOO34_RS02010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HOO34_RS02020	COG0438	transferase activity, transferring glycosyl groups
HOO34_RS02025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOO34_RS02030	COG0251	oxidation-reduction process
HOO34_RS02035	COG3610	response to peptide
HOO34_RS02040	COG2966	Psort location CytoplasmicMembrane, score
HOO34_RS02055	COG0811	peptide transport
HOO34_RS02070	COG1971	Probably functions as a manganese efflux pump
HOO34_RS02095	COG0628	permease
HOO34_RS02105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HOO34_RS02110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HOO34_RS02135	COG4773	Receptor
HOO34_RS02140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HOO34_RS02145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOO34_RS02155	COG0142	geranyltranstransferase activity
HOO34_RS02160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HOO34_RS02165	COG0442	prolyl-tRNA aminoacylation
HOO34_RS02170	COG0668	transmembrane transport
HOO34_RS02190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HOO34_RS02195	COG1862	Preprotein translocase
HOO34_RS02200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO34_RS02205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO34_RS02215	COG1360	Flagellar Motor Protein
HOO34_RS02220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HOO34_RS02230	COG0495	leucyl-tRNA aminoacylation
HOO34_RS02240	COG0285	dihydrofolate synthase activity
HOO34_RS02265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HOO34_RS02290	COG0077	Prephenate dehydratase
HOO34_RS02290	COG1605	Chorismate mutase
HOO34_RS02340	COG2911	Protein conserved in bacteria
HOO34_RS02345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HOO34_RS02350	COG0444	Belongs to the ABC transporter superfamily
HOO34_RS02355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HOO34_RS02360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HOO34_RS02390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOO34_RS02395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HOO34_RS02410	COG0250	Participates in transcription elongation, termination and antitermination
HOO34_RS02415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HOO34_RS02420	COG0081	regulation of translation
HOO34_RS02425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOO34_RS02430	COG0222	ribosome binding
HOO34_RS02435	COG0085	RNA polymerase activity
HOO34_RS02440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOO34_RS02455	COG0582	viral genome integration into host DNA
HOO34_RS02510	COG0358	DNA primase activity
HOO34_RS02565	COG0386	Belongs to the glutathione peroxidase family
HOO34_RS02570	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HOO34_RS02575	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HOO34_RS02610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HOO34_RS02615	COG0298	carbon dioxide binding
HOO34_RS02625	COG4804	nuclease activity
HOO34_RS02635	COG0309	Hydrogenase expression formation protein (HypE)
HOO34_RS02650	COG0310	cobalt ion transport
HOO34_RS02685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HOO34_RS02695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOO34_RS02705	COG1295	ribonuclease BN
HOO34_RS02710	COG0277	FAD linked oxidase domain protein
HOO34_RS02720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HOO34_RS02725	COG2226	methyltransferase
HOO34_RS02730	COG0196	riboflavin kinase activity
HOO34_RS02775	COG1739	Uncharacterized protein family UPF0029
HOO34_RS02795	COG0483	inositol monophosphate 1-phosphatase activity
HOO34_RS02800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HOO34_RS02820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HOO34_RS02840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HOO34_RS02865	COG2194	sulfuric ester hydrolase activity
HOO34_RS02875	COG0438	transferase activity, transferring glycosyl groups
HOO34_RS02880	COG0297	glycogen (starch) synthase activity
HOO34_RS02885	COG0463	Glycosyl transferase, family 2
HOO34_RS02895	COG0859	PFAM glycosyl transferase family 9
HOO34_RS02905	COG1368	sulfuric ester hydrolase activity
HOO34_RS02930	COG1368	sulfuric ester hydrolase activity
HOO34_RS02935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HOO34_RS02940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HOO34_RS02940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HOO34_RS02950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HOO34_RS02960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HOO34_RS02970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HOO34_RS02985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOO34_RS02995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HOO34_RS03055	COG1121	(ABC) transporter
HOO34_RS03060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HOO34_RS03065	COG2996	Protein conserved in bacteria
HOO34_RS03070	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HOO34_RS03090	COG0525	valine-tRNA ligase activity
HOO34_RS03120	COG2814	Major facilitator Superfamily
HOO34_RS03125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HOO34_RS03145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOO34_RS03155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO34_RS03160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HOO34_RS03170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOO34_RS03190	COG0439	Biotin carboxylase
HOO34_RS03205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOO34_RS03215	COG0396	ATPase activity
HOO34_RS03220	COG0719	Fe-S assembly protein
HOO34_RS03235	COG3706	GGDEF domain
HOO34_RS03240	COG0165	Argininosuccinate lyase
HOO34_RS03245	COG0556	nucleotide-excision repair
HOO34_RS03255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HOO34_RS03260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HOO34_RS03265	COG0784	Response regulator, receiver
HOO34_RS03265	COG0835	chemotaxis
HOO34_RS03275	COG0582	viral genome integration into host DNA
HOO34_RS03290	COG4584	PFAM Integrase catalytic
HOO34_RS03295	COG4584	PFAM Integrase catalytic
HOO34_RS03310	COG3328	transposase activity
HOO34_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
HOO34_RS03395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOO34_RS03405	COG2337	Toxic component of a toxin-antitoxin (TA) module
HOO34_RS03440	COG0166	Belongs to the GPI family
HOO34_RS03455	COG1671	Belongs to the UPF0178 family
HOO34_RS03485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOO34_RS03535	COG1459	type II secretion system
HOO34_RS03540	COG0598	Magnesium transport protein CorA
HOO34_RS03595	COG2217	Heavy metal translocating P-type atpase
HOO34_RS03610	COG1278	Cold shock
HOO34_RS03630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOO34_RS03645	COG1522	sequence-specific DNA binding
HOO34_RS03650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO34_RS03650	COG1648	precorrin-2 dehydrogenase activity
HOO34_RS03660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO34_RS03660	COG1648	precorrin-2 dehydrogenase activity
HOO34_RS03670	COG0535	radical SAM domain protein
HOO34_RS03680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HOO34_RS03685	COG2010	Cytochrome c
HOO34_RS03690	COG2010	Cytochrome c
HOO34_RS03700	COG3256	nitric oxide reductase
HOO34_RS03720	COG1355	regulation of microtubule-based process
HOO34_RS03725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HOO34_RS03765	COG2326	polyphosphate kinase activity
HOO34_RS03770	COG0544	peptidyl-prolyl cis-trans isomerase activity
HOO34_RS03775	COG0740	serine-type endopeptidase activity
HOO34_RS03780	COG0242	peptide deformylase activity
HOO34_RS03795	COG0840	transmembrane signaling receptor activity
HOO34_RS03800	COG0606	chelatase, subunit chli
HOO34_RS03825	COG0708	Exodeoxyribonuclease III
HOO34_RS03840	COG0051	transcription antitermination factor activity, RNA binding
HOO34_RS03845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOO34_RS03850	COG0088	Forms part of the polypeptide exit tunnel
HOO34_RS03855	COG0089	rRNA binding
HOO34_RS03860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HOO34_RS03865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOO34_RS03870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOO34_RS03875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOO34_RS03880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HOO34_RS03885	COG0255	Belongs to the universal ribosomal protein uL29 family
HOO34_RS03890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOO34_RS03895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HOO34_RS03900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HOO34_RS03905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOO34_RS03910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOO34_RS03915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HOO34_RS03920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOO34_RS03925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HOO34_RS03930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HOO34_RS03935	COG0200	Binds to the 23S rRNA
HOO34_RS03940	COG0201	protein transport
HOO34_RS03945	COG0024	Methionine aminopeptidase
HOO34_RS03950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOO34_RS03955	COG1573	uracil-dna glycosylase
HOO34_RS03965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HOO34_RS03970	COG1032	radical SAM domain protein
HOO34_RS03980	COG0583	DNA-binding transcription factor activity
HOO34_RS04000	COG2855	membrane
HOO34_RS04025	COG1696	Membrane protein involved in D-alanine export
HOO34_RS04030	COG0840	transmembrane signaling receptor activity
HOO34_RS04035	COG0012	GTP binding
HOO34_RS04040	COG1639	'signal transduction protein
HOO34_RS04055	COG3123	guanosine phosphorylase activity
HOO34_RS04070	COG0730	response to heat
HOO34_RS04075	COG1045	serine acetyltransferase
HOO34_RS04080	COG1166	arginine decarboxylase activity
HOO34_RS04085	COG0124	histidyl-tRNA synthetase
HOO34_RS04090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HOO34_RS04095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOO34_RS04100	COG0163	prenyltransferase activity
HOO34_RS04110	COG0359	binds to the 23S rRNA
HOO34_RS04115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HOO34_RS04120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HOO34_RS04130	COG0084	hydrolase, TatD family'
HOO34_RS04140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HOO34_RS04145	COG0131	Imidazoleglycerol-phosphate dehydratase
HOO34_RS04165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HOO34_RS04170	COG0456	acetyltransferase
HOO34_RS04185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HOO34_RS04195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO34_RS04200	COG0328	RNA-DNA hybrid ribonuclease activity
HOO34_RS04205	COG0840	transmembrane signaling receptor activity
HOO34_RS04220	COG0513	Belongs to the DEAD box helicase family
HOO34_RS04225	COG2217	Heavy metal translocating P-type atpase
HOO34_RS04260	COG0745	RESPONSE REGULATOR receiver
HOO34_RS04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO34_RS04295	COG3437	response regulator, receiver
HOO34_RS04295	COG0784	Response regulator, receiver
HOO34_RS04305	COG1338	Plays a role in the flagellum-specific transport system
HOO34_RS04310	COG0768	penicillin binding
HOO34_RS04330	COG2884	Cell division ATP-binding protein ftsE
HOO34_RS04335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOO34_RS04345	COG0564	pseudouridine synthase activity
HOO34_RS04350	COG0772	Belongs to the SEDS family
HOO34_RS04360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HOO34_RS04365	COG3123	guanosine phosphorylase activity
HOO34_RS04450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HOO34_RS04455	COG0475	glutathione-regulated potassium exporter activity
HOO34_RS04455	COG0569	domain protein
HOO34_RS04460	COG0210	DNA helicase
HOO34_RS04465	COG0709	Synthesizes selenophosphate from selenide and ATP
HOO34_RS04470	COG1305	Transglutaminase-like
HOO34_RS04490	COG2204	response regulator
HOO34_RS04530	COG0437	4 iron, 4 sulfur cluster binding
HOO34_RS04540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HOO34_RS04565	COG2998	abc-type tungstate transport system, permease component
HOO34_RS04570	COG4662	Binding-protein-dependent transport system inner membrane component
HOO34_RS04590	COG2814	Major facilitator Superfamily
HOO34_RS04605	COG2354	Protein conserved in bacteria
HOO34_RS04615	COG2081	HI0933 family
HOO34_RS04620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HOO34_RS04650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOO34_RS04675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HOO34_RS04680	COG2171	N-acyltransferase activity
HOO34_RS04685	COG1944	ATP diphosphatase activity
HOO34_RS04690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOO34_RS04690	COG2169	Transcriptional regulator
HOO34_RS04695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO34_RS04725	COG4536	flavin adenine dinucleotide binding
HOO34_RS04755	COG0628	permease
HOO34_RS04760	COG2255	four-way junction helicase activity
HOO34_RS04765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HOO34_RS04770	COG0159	tryptophan synthase activity
HOO34_RS04775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HOO34_RS04785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HOO34_RS04800	COG0137	argininosuccinate synthase activity
HOO34_RS04805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO34_RS04810	COG0742	ribosomal rna small subunit methyltransferase
HOO34_RS04815	COG1418	mRNA catabolic process
HOO34_RS04830	COG0552	protein localization to endoplasmic reticulum
HOO34_RS04860	COG2249	NAD(P)H dehydrogenase (quinone) activity
HOO34_RS04865	COG0778	Nitroreductase
HOO34_RS04875	COG0488	(ABC) transporter
HOO34_RS04880	COG1607	acyl-coa hydrolase
HOO34_RS04885	COG0840	transmembrane signaling receptor activity
HOO34_RS04890	COG0840	transmembrane signaling receptor activity
HOO34_RS04900	COG0484	heat shock protein binding
HOO34_RS04905	COG0484	heat shock protein binding
HOO34_RS04925	COG0300	oxidoreductase activity
HOO34_RS04935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO34_RS04940	COG0802	atpase or kinase
HOO34_RS04945	COG1137	ATPase activity
HOO34_RS04950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HOO34_RS04960	COG2201	protein-glutamate methylesterase activity
HOO34_RS04970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HOO34_RS04975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HOO34_RS05020	COG2076	Multidrug Resistance protein
HOO34_RS05025	COG0642	Histidine kinase
HOO34_RS05040	COG3258	Cytochrome c
HOO34_RS05050	COG1049	propionate catabolic process, 2-methylcitrate cycle
HOO34_RS05055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HOO34_RS05060	COG2363	Small membrane protein
HOO34_RS05065	COG1666	GTP binding
HOO34_RS05105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HOO34_RS05120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO34_RS05120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO34_RS05130	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HOO34_RS05160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOO34_RS05170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOO34_RS05175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO34_RS05180	COG0287	Prephenate dehydrogenase
HOO34_RS05195	COG0243	molybdopterin cofactor binding
HOO34_RS05205	COG1921	L-seryl-tRNASec selenium transferase activity
HOO34_RS05220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOO34_RS05225	COG0135	phosphoribosylanthranilate isomerase activity
HOO34_RS05230	COG2176	DNA-directed DNA polymerase activity
HOO34_RS05240	COG1013	pyruvate-flavodoxin oxidoreductase activity
HOO34_RS05245	COG0674	pyruvate-flavodoxin oxidoreductase activity
HOO34_RS05245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HOO34_RS05255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HOO34_RS05260	COG0727	PFAM Uncharacterised protein family (UPF0153)
HOO34_RS05270	COG0134	indole-3-glycerol-phosphate synthase activity
HOO34_RS05275	COG0583	DNA-binding transcription factor activity
HOO34_RS05280	COG1942	4-Oxalocrotonate Tautomerase
HOO34_RS05285	COG3706	GGDEF domain
HOO34_RS05295	COG0739	heme binding
HOO34_RS05305	COG0488	(ABC) transporter
HOO34_RS05310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOO34_RS05330	COG0667	Aldo Keto reductase
HOO34_RS05335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO34_RS05340	COG0805	protein transport
HOO34_RS05345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HOO34_RS05355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HOO34_RS05370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HOO34_RS05375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO34_RS05380	COG1663	tetraacyldisaccharide 4'-kinase activity
HOO34_RS05385	COG0861	Integral membrane protein TerC family
HOO34_RS05390	COG0789	Transcriptional regulator
HOO34_RS05395	COG0484	heat shock protein binding
HOO34_RS05400	COG4191	Histidine kinase
HOO34_RS05410	COG2201	protein-glutamate methylesterase activity
HOO34_RS05430	COG0776	regulation of translation
HOO34_RS05440	COG0275	rRNA processing
HOO34_RS05470	COG0039	L-malate dehydrogenase activity
HOO34_RS05480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOO34_RS05495	COG1193	negative regulation of DNA recombination
HOO34_RS05500	COG1253	flavin adenine dinucleotide binding
HOO34_RS05515	COG1119	ATPase activity
HOO34_RS05525	COG2258	MOSC domain
HOO34_RS05535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HOO34_RS05540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HOO34_RS05545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOO34_RS05545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO34_RS05565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HOO34_RS05580	COG0527	aspartate kinase activity
HOO34_RS05585	COG0494	nUDIX hydrolase
HOO34_RS05600	COG0339	signal peptide processing
HOO34_RS05645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HOO34_RS05760	COG0582	viral genome integration into host DNA
HOO34_RS05765	COG0824	Thioesterase
HOO34_RS05770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOO34_RS05775	COG0501	Belongs to the peptidase M48B family
HOO34_RS05785	COG2321	neutral zinc metallopeptidase
HOO34_RS05795	COG0303	'Molybdopterin
HOO34_RS05805	COG0037	tRNA processing
HOO34_RS05840	COG0028	Belongs to the TPP enzyme family
HOO34_RS05845	COG0440	acetolactate synthase activity
HOO34_RS05850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO34_RS05855	COG1196	nuclear chromosome segregation
HOO34_RS05855	COG1674	ftsk spoiiie
HOO34_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
HOO34_RS05875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOO34_RS05880	COG1160	GTP binding
HOO34_RS05885	COG0659	secondary active sulfate transmembrane transporter activity
HOO34_RS05905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HOO34_RS05915	COG1185	polyribonucleotide nucleotidyltransferase activity
HOO34_RS05920	COG0745	RESPONSE REGULATOR receiver
HOO34_RS05925	COG0643	Histidine kinase
HOO34_RS05925	COG2198	Histidine kinase
HOO34_RS05930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HOO34_RS05940	COG2201	protein-glutamate methylesterase activity
HOO34_RS05945	COG0582	viral genome integration into host DNA
HOO34_RS05950	COG0484	heat shock protein binding
HOO34_RS05975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOO34_RS05990	COG0500	methyltransferase
HOO34_RS06005	COG1333	cytochrome c biogenesis protein
HOO34_RS06005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HOO34_RS06025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HOO34_RS06030	COG0653	protein targeting
HOO34_RS06040	COG0521	Mo-molybdopterin cofactor biosynthetic process
HOO34_RS06050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOO34_RS06055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO34_RS06070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HOO34_RS06100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOO34_RS06130	COG0546	phosphoglycolate phosphatase activity
HOO34_RS06140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HOO34_RS06165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HOO34_RS06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO34_RS06175	COG4191	Histidine kinase
HOO34_RS06185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HOO34_RS06185	COG0475	glutathione-regulated potassium exporter activity
HOO34_RS06215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HOO34_RS06220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HOO34_RS06220	COG0519	Catalyzes the synthesis of GMP from XMP
HOO34_RS06250	COG0596	Alpha beta hydrolase
HOO34_RS06265	COG5001	Diguanylate cyclase
HOO34_RS06265	COG5002	protein histidine kinase activity
HOO34_RS06270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOO34_RS06275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HOO34_RS06290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HOO34_RS06330	COG0415	Belongs to the DNA photolyase family
HOO34_RS06335	COG1090	epimerase
HOO34_RS06345	COG3040	lipid binding
HOO34_RS06350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOO34_RS06380	COG2200	EAL domain
HOO34_RS06390	COG3275	phosphorelay sensor kinase activity
HOO34_RS06415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO34_RS06415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO34_RS06420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HOO34_RS06430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOO34_RS06435	COG0735	belongs to the Fur family
HOO34_RS06445	COG0728	peptidoglycan biosynthetic process
HOO34_RS06450	COG1132	(ABC) transporter
HOO34_RS06455	COG0167	dihydroorotate dehydrogenase activity
HOO34_RS06460	COG0612	Peptidase, M16
HOO34_RS06465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOO34_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
HOO34_RS06475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOO34_RS06480	COG0750	zinc metalloprotease
HOO34_RS06485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HOO34_RS06495	COG0840	transmembrane signaling receptor activity
HOO34_RS06505	COG0642	Histidine kinase
HOO34_RS06510	COG0745	RESPONSE REGULATOR receiver
HOO34_RS06520	COG1132	(ABC) transporter
HOO34_RS06525	COG0217	transcriptional regulatory protein
HOO34_RS06545	COG1611	Belongs to the LOG family
HOO34_RS06550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO34_RS06570	COG0351	phosphomethylpyrimidine kinase
HOO34_RS06570	COG0352	thiamine-phosphate diphosphorylase activity
HOO34_RS06575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOO34_RS06605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOO34_RS06610	COG1696	Membrane protein involved in D-alanine export
HOO34_RS06625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO34_RS06700	COG5002	protein histidine kinase activity
HOO34_RS06705	COG0745	RESPONSE REGULATOR receiver
HOO34_RS06725	COG1114	Component of the transport system for branched-chain amino acids
HOO34_RS06730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HOO34_RS06735	COG0788	formyltetrahydrofolate deformylase activity
HOO34_RS06750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOO34_RS06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO34_RS06790	COG0513	Belongs to the DEAD box helicase family
HOO34_RS06800	COG0754	glutathionylspermidine amidase activity
HOO34_RS06805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HOO34_RS06815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOO34_RS06820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOO34_RS06825	COG0517	IMP dehydrogenase activity
HOO34_RS06825	COG0516	GMP reductase activity
HOO34_RS06830	COG0154	amidase activity
HOO34_RS06835	COG0203	ribosomal protein L17
HOO34_RS06840	COG0202	RNA polymerase activity
HOO34_RS06845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOO34_RS06850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOO34_RS06855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOO34_RS06860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HOO34_RS06875	COG0473	3-isopropylmalate dehydrogenase activity
HOO34_RS06880	COG0066	3-isopropylmalate dehydratase activity
HOO34_RS06885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HOO34_RS06890	COG4974	Belongs to the 'phage' integrase family
HOO34_RS06895	COG3328	transposase activity
HOO34_RS06990	COG0358	DNA primase activity
HOO34_RS07070	COG3550	peptidyl-serine autophosphorylation
HOO34_RS07080	COG4584	PFAM Integrase catalytic
HOO34_RS07115	COG0357	Ribosomal RNA small subunit methyltransferase G
HOO34_RS07120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOO34_RS07125	COG0113	porphobilinogen synthase activity
HOO34_RS07180	COG1484	DNA-dependent DNA replication
HOO34_RS07190	COG4584	PFAM Integrase catalytic
HOO34_RS07200	COG0582	viral genome integration into host DNA
HOO34_RS07230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOO34_RS07245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HOO34_RS07260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HOO34_RS07265	COG0849	cell division
HOO34_RS07275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOO34_RS07285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOO34_RS07295	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO34_RS07300	COG0488	(ABC) transporter
HOO34_RS07345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HOO34_RS07355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HOO34_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOO34_RS07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOO34_RS07370	COG0840	transmembrane signaling receptor activity
HOO34_RS07375	COG0322	excinuclease ABC activity
HOO34_RS07380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOO34_RS07385	COG0840	transmembrane signaling receptor activity
HOO34_RS07390	COG1979	alcohol dehydrogenase
HOO34_RS07395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HOO34_RS07420	COG0563	adenylate kinase activity
HOO34_RS07425	COG0563	adenylate kinase activity
HOO34_RS07430	COG1966	Carbon starvation protein
HOO34_RS07445	COG4771	TonB-dependent receptor
HOO34_RS07455	COG0673	inositol 2-dehydrogenase activity
HOO34_RS07470	COG0305	Participates in initiation and elongation during chromosome replication
HOO34_RS07475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOO34_RS07490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HOO34_RS07495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO34_RS07505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO34_RS07510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HOO34_RS07515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HOO34_RS07525	COG3706	GGDEF domain
HOO34_RS07535	COG3300	MHYT domain
HOO34_RS07535	COG5001	Diguanylate cyclase
HOO34_RS07560	COG0706	membrane insertase activity
HOO34_RS07565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HOO34_RS07575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HOO34_RS07580	COG0542	response to heat
HOO34_RS07585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOO34_RS07590	COG1136	(ABC) transporter
HOO34_RS07590	COG0577	efflux transmembrane transporter activity
HOO34_RS07610	COG0811	peptide transport
HOO34_RS07615	COG0848	biopolymer transport protein
HOO34_RS07635	COG1686	Belongs to the peptidase S11 family
HOO34_RS07640	COG0459	protein refolding
HOO34_RS07655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HOO34_RS07660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HOO34_RS07670	COG0835	chemotaxis
HOO34_RS07675	COG1570	exodeoxyribonuclease VII activity
HOO34_RS07695	COG1692	metallophosphoesterase
HOO34_RS07700	COG5002	protein histidine kinase activity
HOO34_RS07705	COG3920	Histidine kinase
HOO34_RS07720	COG0840	transmembrane signaling receptor activity
HOO34_RS07725	COG2081	HI0933 family
HOO34_RS07730	COG0642	Histidine kinase
HOO34_RS07735	COG0745	RESPONSE REGULATOR receiver
HOO34_RS07745	COG3706	GGDEF domain
HOO34_RS07745	COG2203	Gaf domain
HOO34_RS07745	COG4251	negative regulation of phosphorylation
HOO34_RS07745	COG5001	Diguanylate cyclase
HOO34_RS07755	COG2204	response regulator
HOO34_RS07780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOO34_RS07785	COG1116	anion transmembrane transporter activity
HOO34_RS07800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOO34_RS07830	COG1858	cytochrome C peroxidase
HOO34_RS07835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOO34_RS07840	COG0768	penicillin binding
HOO34_RS07845	COG0772	Belongs to the SEDS family
HOO34_RS07855	COG1968	undecaprenyl-diphosphatase activity
HOO34_RS07860	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOO34_RS07870	COG0314	molybdopterin synthase activity
HOO34_RS07880	COG0174	glutamine synthetase
HOO34_RS07885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HOO34_RS07890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOO34_RS07895	COG0284	orotidine-5'-phosphate decarboxylase activity
HOO34_RS07930	COG1181	Belongs to the D-alanine--D-alanine ligase family
HOO34_RS07935	COG0632	four-way junction helicase activity
HOO34_RS07950	COG0585	pseudouridine synthase activity
HOO34_RS07955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HOO34_RS07960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HOO34_RS07985	COG1178	ABC-type Fe3 transport system permease component
HOO34_RS07990	COG1840	ABC-type Fe3 transport system, periplasmic component
HOO34_RS07995	COG0512	Glutamine amidotransferase of anthranilate synthase
HOO34_RS08035	COG5001	Diguanylate cyclase
HOO34_RS08035	COG5002	protein histidine kinase activity
HOO34_RS08040	COG0194	GDP metabolic process
HOO34_RS08050	COG1136	(ABC) transporter
HOO34_RS08055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HOO34_RS08060	COG0052	Belongs to the universal ribosomal protein uS2 family
HOO34_RS08080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HOO34_RS08085	COG0579	oxidoreductase
HOO34_RS08090	COG1546	Belongs to the CinA family
HOO34_RS08090	COG1058	Belongs to the CinA family
HOO34_RS08150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO34_RS08160	COG2176	DNA-directed DNA polymerase activity
HOO34_RS08170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO34_RS08200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOO34_RS08205	COG0280	phosphate acetyltransferase
HOO34_RS08210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOO34_RS08215	COG0616	signal peptide processing
HOO34_RS08220	COG0402	S-adenosylhomocysteine deaminase activity
HOO34_RS08225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HOO34_RS08230	COG0006	proline dipeptidase activity
HOO34_RS08235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HOO34_RS08240	COG0482	sulfurtransferase activity
HOO34_RS08245	COG0482	sulfurtransferase activity
HOO34_RS08255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOO34_RS08265	COG0481	GTPase activity
HOO34_RS08315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOO34_RS08320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HOO34_RS08325	COG3706	GGDEF domain
HOO34_RS08335	COG2095	MarC family integral membrane protein
HOO34_RS08340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HOO34_RS08355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO34_RS08365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOO34_RS08370	COG2264	protein methyltransferase activity
HOO34_RS08375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOO34_RS08385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HOO34_RS08395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOO34_RS08400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOO34_RS08415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOO34_RS08430	COG0840	transmembrane signaling receptor activity
HOO34_RS08470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HOO34_RS08480	COG0133	tryptophan synthase activity
HOO34_RS08485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOO34_RS08490	COG1793	dna ligase
HOO34_RS08500	COG0626	cystathionine gamma-synthase activity
HOO34_RS08535	COG0745	RESPONSE REGULATOR receiver
HOO34_RS08560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HOO34_RS08560	COG2111	Na H antiporter
HOO34_RS08565	COG1006	Multisubunit Na H antiporter MnhC subunit
HOO34_RS08570	COG0651	ATP synthesis coupled electron transport
HOO34_RS08575	COG1863	multisubunit Na H antiporter MnhE subunit
HOO34_RS08580	COG2212	antiporter activity
HOO34_RS08585	COG1320	monovalent cation:proton antiporter activity
HOO34_RS08590	COG0528	UMP kinase activity
HOO34_RS08595	COG1758	RNA polymerase activity
HOO34_RS08600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOO34_RS08605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOO34_RS08615	COG0860	N-Acetylmuramoyl-L-alanine amidase
HOO34_RS08630	COG0193	aminoacyl-tRNA hydrolase activity
HOO34_RS08635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HOO34_RS08640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOO34_RS08645	COG0681	Belongs to the peptidase S26 family
HOO34_RS08650	COG0698	ribose 5-phosphate isomerase
HOO34_RS08695	COG3287	FIST C domain
HOO34_RS08695	COG2200	EAL domain
HOO34_RS08695	COG2199	diguanylate cyclase activity
HOO34_RS08700	COG0259	pyridoxamine-phosphate oxidase activity
HOO34_RS08715	COG0513	Belongs to the DEAD box helicase family
HOO34_RS08735	COG0326	Molecular chaperone. Has ATPase activity
HOO34_RS08745	COG2205	protein histidine kinase activity
HOO34_RS08745	COG3437	response regulator, receiver
HOO34_RS08745	COG3850	Histidine kinase
HOO34_RS08745	COG4999	Histidine kinase
HOO34_RS08755	COG0010	Belongs to the arginase family
HOO34_RS08765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOO34_RS08775	COG2264	protein methyltransferase activity
HOO34_RS08795	COG2995	paraquat-inducible protein a
HOO34_RS08800	COG3008	intermembrane lipid transfer
HOO34_RS08805	COG0753	catalase activity
HOO34_RS08820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HOO34_RS08825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO34_RS08835	COG0668	transmembrane transport
HOO34_RS08840	COG1227	inorganic diphosphatase activity
HOO34_RS08850	COG1027	Aspartate ammonia-lyase
HOO34_RS08870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOO34_RS08875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HOO34_RS08880	COG1047	Peptidyl-prolyl cis-trans
HOO34_RS08895	COG0823	Involved in the tonB-independent uptake of proteins
HOO34_RS08905	COG0848	biopolymer transport protein
HOO34_RS08910	COG0811	peptide transport
HOO34_RS08915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HOO34_RS08920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOO34_RS08925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOO34_RS08930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HOO34_RS08935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOO34_RS08940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOO34_RS08950	COG1475	DNA binding
HOO34_RS08955	COG1192	Involved in chromosome partitioning
HOO34_RS08970	COG0840	transmembrane signaling receptor activity
HOO34_RS08975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOO34_RS08980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOO34_RS08985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOO34_RS08990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HOO34_RS08995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HOO34_RS09050	COG0037	tRNA processing
HOO34_RS09080	COG0582	viral genome integration into host DNA
HOO34_RS09085	COG0358	DNA primase activity
HOO34_RS09095	COG0571	ribonuclease III activity
HOO34_RS09100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HOO34_RS09110	COG2326	polyphosphate kinase activity
HOO34_RS09125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO34_RS09150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOO34_RS09160	COG0741	lytic transglycosylase activity
HOO34_RS09160	COG1196	nuclear chromosome segregation
HOO34_RS09160	COG0739	heme binding
HOO34_RS09180	COG2183	response to ionizing radiation
HOO34_RS09185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HOO34_RS09190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO34_RS09195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO34_RS09200	COG0649	NAD binding
HOO34_RS09200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO34_RS09205	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HOO34_RS09215	COG0372	Belongs to the citrate synthase family
HOO34_RS09225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HOO34_RS09230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOO34_RS09235	COG0839	Belongs to the complex I subunit 6 family
HOO34_RS09240	COG0713	ATP synthesis coupled electron transport
HOO34_RS09245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HOO34_RS09255	COG1007	ATP synthesis coupled electron transport
HOO34_RS09265	COG1053	succinate dehydrogenase
HOO34_RS09270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HOO34_RS09290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOO34_RS09295	COG0416	fatty acid biosynthetic process
HOO34_RS09300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HOO34_RS09310	COG0105	UTP biosynthetic process
HOO34_RS09320	COG0450	alkyl hydroperoxide reductase
HOO34_RS09325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HOO34_RS09330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HOO34_RS09335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HOO34_RS09340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HOO34_RS09350	COG0181	hydroxymethylbilane synthase activity
HOO34_RS09355	COG1335	isochorismatase
HOO34_RS09395	COG3278	Belongs to the heme-copper respiratory oxidase family
HOO34_RS09400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HOO34_RS09405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HOO34_RS09410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HOO34_RS09425	COG1242	4 iron, 4 sulfur cluster binding
HOO34_RS09430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HOO34_RS09435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HOO34_RS09440	COG0492	ferredoxin-NADP+ reductase activity
HOO34_RS09445	COG3118	belongs to the thioredoxin family
HOO34_RS09450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOO34_RS09475	COG0642	Histidine kinase
HOO34_RS09480	COG0745	RESPONSE REGULATOR receiver
HOO34_RS09490	COG0129	dihydroxy-acid dehydratase activity
HOO34_RS09520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOO34_RS09540	COG0585	pseudouridine synthase activity
HOO34_RS09555	COG0793	Belongs to the peptidase S41A family
HOO34_RS09560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HOO34_RS09565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOO34_RS09570	COG0047	phosphoribosylformylglycinamidine synthase activity
HOO34_RS09580	COG0204	Acyl-transferase
HOO34_RS09585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOO34_RS09590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO34_RS09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO34_RS09600	COG0018	arginyl-trna synthetase
HOO34_RS09610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOO34_RS09635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO34_RS09640	COG0126	phosphoglycerate kinase activity
HOO34_RS09645	COG0149	triose-phosphate isomerase activity
HOO34_RS09650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HOO34_RS09655	COG0019	diaminopimelate decarboxylase activity
HOO34_RS09660	COG0077	Prephenate dehydratase
HOO34_RS09660	COG1605	Chorismate mutase
HOO34_RS09665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOO34_RS09670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOO34_RS09685	COG0424	maF-like protein
HOO34_RS09695	COG0791	NLP P60 protein
HOO34_RS09720	COG0189	ligase activity
HOO34_RS09735	COG3287	FIST C domain
HOO34_RS09735	COG2200	EAL domain
HOO34_RS09735	COG2199	diguanylate cyclase activity
HOO34_RS09740	COG0688	phosphatidylethanolamine metabolic process
HOO34_RS09800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOO34_RS09810	COG0288	reversible hydration of carbon dioxide
HOO34_RS09815	COG0156	8-amino-7-oxononanoate synthase activity
HOO34_RS09820	COG0792	nuclease activity
HOO34_RS09840	COG5002	protein histidine kinase activity
HOO34_RS09845	COG0745	RESPONSE REGULATOR receiver
HOO34_RS09860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HOO34_RS09895	COG1987	bacterial-type flagellum assembly
HOO34_RS09905	COG1706	bacterial-type flagellum-dependent cell motility
HOO34_RS09920	COG0347	Belongs to the P(II) protein family
HOO34_RS09925	COG0004	ammonium transporteR
HOO34_RS09930	COG0666	response to abiotic stimulus
HOO34_RS09935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HOO34_RS09970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOO34_RS09980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HOO34_RS10000	COG0840	transmembrane signaling receptor activity
HOO34_RS10050	COG2022	thiamine diphosphate biosynthetic process
HOO34_RS10055	COG1324	tolerance protein
HOO34_RS10060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HOO34_RS10060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HOO34_RS10070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOO34_RS10085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HOO34_RS10090	COG0575	Belongs to the CDS family
HOO34_RS10115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOO34_RS10120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HOO34_RS10125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HOO34_RS10130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HOO34_RS10140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO34_RS10150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HOO34_RS10155	COG1393	Belongs to the ArsC family
HOO34_RS10160	COG2828	Protein conserved in bacteria
HOO34_RS10165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HOO34_RS10175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HOO34_RS10185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOO34_RS10190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HOO34_RS10195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HOO34_RS10200	COG0560	Phosphoserine phosphatase
HOO34_RS10210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOO34_RS10215	COG0786	glutamate:sodium symporter activity
HOO34_RS10230	COG0736	holo-[acyl-carrier-protein] synthase activity
HOO34_RS10235	COG0601	transmembrane transport
HOO34_RS10240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HOO34_RS10250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO34_RS10280	COG2824	Alkylphosphonate utilization operon protein PhnA
HOO34_RS10285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HOO34_RS10290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HOO34_RS10295	COG0573	inorganic phosphate transmembrane transporter activity
HOO34_RS10300	COG0581	inorganic phosphate transmembrane transporter activity
HOO34_RS10305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HOO34_RS10310	COG0704	Plays a role in the regulation of phosphate uptake
HOO34_RS10320	COG0745	RESPONSE REGULATOR receiver
HOO34_RS10330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HOO34_RS10335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HOO34_RS10340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HOO34_RS10355	COG0546	phosphoglycolate phosphatase activity
HOO34_RS10380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HOO34_RS10385	COG1854	S-ribosylhomocysteine lyase activity
HOO34_RS10395	COG1686	Belongs to the peptidase S11 family
HOO34_RS10405	COG5002	protein histidine kinase activity
HOO34_RS10410	COG0646	methionine synthase
HOO34_RS10410	COG1410	methionine synthase
HOO34_RS10435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HOO34_RS10435	COG0140	phosphoribosyl-ATP diphosphatase activity
HOO34_RS10450	COG0456	acetyltransferase
HOO34_RS10455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOO34_RS10460	COG1917	Cupin 2, conserved barrel domain protein
HOO34_RS10465	COG0489	protein tyrosine kinase activity
HOO34_RS10470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HOO34_RS10480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HOO34_RS10480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HOO34_RS10490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HOO34_RS10495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOO34_RS10500	COG0268	Binds directly to 16S ribosomal RNA
HOO34_RS10505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOO34_RS10510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HOO34_RS10515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOO34_RS10525	COG0540	Belongs to the ATCase OTCase family
HOO34_RS10530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO34_RS10535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HOO34_RS10540	COG0505	Belongs to the CarA family
HOO34_RS10550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOO34_RS10555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HOO34_RS10560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HOO34_RS10600	COG4895	conserved protein (DUF2196)
HOO34_RS10605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO34_RS10610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HOO34_RS10615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HOO34_RS10620	COG0237	dephospho-CoA kinase activity
HOO34_RS10635	COG0348	domain, Protein
HOO34_RS10640	COG0504	CTP synthase activity
HOO34_RS10645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HOO34_RS10645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HOO34_RS10660	COG0693	protein deglycase activity
HOO34_RS10665	COG0587	DNA-directed DNA polymerase activity
HOO34_RS10670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HOO34_RS10685	COG0315	cyclic pyranopterin monophosphate synthase activity
HOO34_RS10690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HOO34_RS10785	COG0109	protoheme IX farnesyltransferase activity
HOO34_RS10795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HOO34_RS10800	COG0254	rRNA binding
HOO34_RS10805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HOO34_RS10810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOO34_RS10820	COG0436	Aminotransferase
HOO34_RS10825	COG0460	homoserine dehydrogenase
HOO34_RS10830	COG0513	Belongs to the DEAD box helicase family
HOO34_RS10835	COG0439	Biotin carboxylase
HOO34_RS10840	COG0511	ligase activity, forming carbon-carbon bonds
HOO34_RS10845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO34_RS10845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO34_RS10855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOO34_RS10860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HOO34_RS10865	COG0604	alcohol dehydrogenase
HOO34_RS10880	COG0745	RESPONSE REGULATOR receiver
HOO34_RS10895	COG4206	TonB-dependent receptor
HOO34_RS10905	COG3047	cAMP biosynthetic process
HOO34_RS10905	COG2885	chlorophyll binding
HOO34_RS10910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO34_RS10915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO34_RS10920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOO34_RS10925	COG0564	pseudouridine synthase activity
HOO34_RS10955	COG0133	tryptophan synthase activity
HOO34_RS10960	COG2353	YceI-like domain
HOO34_RS10965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO34_RS10985	COG0642	Histidine kinase
HOO34_RS10990	COG0745	RESPONSE REGULATOR receiver
HOO34_RS10995	COG0724	RNA recognition motif
HOO34_RS11000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOO34_RS11005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HOO34_RS11020	COG0107	imidazoleglycerol-phosphate synthase activity
HOO34_RS11025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HOO34_RS11035	COG0517	IMP dehydrogenase activity
HOO34_RS11035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HOO34_RS11040	COG1187	pseudouridine synthase activity
HOO34_RS11045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HOO34_RS11045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HOO34_RS11050	COG1981	membrane
HOO34_RS11055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HOO34_RS11065	COG0367	asparagine synthase
HOO34_RS11075	COG0306	phosphate transporter
HOO34_RS11095	COG2337	Toxic component of a toxin-antitoxin (TA) module
HOO34_RS11105	COG1408	metallophosphoesterase
HOO34_RS11120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HOO34_RS11125	COG4208	sulfate ABC transporter
HOO34_RS11130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HOO34_RS11135	COG3287	FIST C domain
HOO34_RS11135	COG2199	diguanylate cyclase activity
HOO34_RS11135	COG2200	EAL domain
HOO34_RS11150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HOO34_RS11155	COG1959	2 iron, 2 sulfur cluster binding
HOO34_RS11160	COG1217	gtp-binding protein TYPA
HOO34_RS11180	COG3437	response regulator, receiver
HOO34_RS11185	COG3706	GGDEF domain
HOO34_RS11215	COG0745	RESPONSE REGULATOR receiver
HOO34_RS11220	COG0642	Histidine kinase
HOO34_RS11225	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HOO34_RS11230	COG2860	membrane
HOO34_RS11240	COG0840	transmembrane signaling receptor activity
HOO34_RS11260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group