locus-tag	class	description
C3B42_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3B42_RS00010	COG0592	DNA-directed DNA polymerase activity
C3B42_RS00015	COG0187	DNA topoisomerase II activity
C3B42_RS00020	COG0492	ferredoxin-NADP+ reductase activity
C3B42_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3B42_RS00050	COG0500	methyltransferase
C3B42_RS00055	COG3842	ATPase activity
C3B42_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3B42_RS00120	COG0840	transmembrane signaling receptor activity
C3B42_RS00125	COG0840	transmembrane signaling receptor activity
C3B42_RS00130	COG2081	HI0933 family
C3B42_RS00145	COG1959	2 iron, 2 sulfur cluster binding
C3B42_RS00165	COG0175	sulfate reduction
C3B42_RS00170	COG2895	sulfate adenylyltransferase (ATP) activity
C3B42_RS00180	COG2814	Major facilitator Superfamily
C3B42_RS00185	COG0783	Belongs to the Dps family
C3B42_RS00190	COG0546	phosphoglycolate phosphatase activity
C3B42_RS00200	COG1012	belongs to the aldehyde dehydrogenase family
C3B42_RS00205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3B42_RS00220	COG3022	response to hydroperoxide
C3B42_RS00240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3B42_RS00245	COG0233	cytoplasmic translational termination
C3B42_RS00250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3B42_RS00260	COG0352	thiamine-phosphate diphosphorylase activity
C3B42_RS00265	COG0670	Belongs to the BI1 family
C3B42_RS00295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3B42_RS00325	COG0598	Magnesium transport protein CorA
C3B42_RS00340	COG1178	ABC-type Fe3 transport system permease component
C3B42_RS00345	COG1840	ABC-type Fe3 transport system, periplasmic component
C3B42_RS00405	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3B42_RS00410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3B42_RS00415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3B42_RS00420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3B42_RS00425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3B42_RS00430	COG1077	Cell shape determining protein MreB Mrl
C3B42_RS00445	COG0445	tRNA wobble uridine modification
C3B42_RS00450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3B42_RS00460	COG2814	Major facilitator Superfamily
C3B42_RS00475	COG0659	secondary active sulfate transmembrane transporter activity
C3B42_RS00490	COG1222	aaa ATPase
C3B42_RS00500	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C3B42_RS00505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3B42_RS00520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3B42_RS00525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3B42_RS00535	COG1086	Polysaccharide biosynthesis protein
C3B42_RS00540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3B42_RS00545	COG1083	cytidylyl-transferase
C3B42_RS00560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B42_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
C3B42_RS00600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B42_RS00615	COG0318	PFAM AMP-dependent synthetase and ligase
C3B42_RS00615	COG0204	Acyl-transferase
C3B42_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
C3B42_RS00635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B42_RS00640	COG2089	acid synthase
C3B42_RS00645	COG3980	spore coat polysaccharide biosynthesis protein
C3B42_RS00675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3B42_RS00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3B42_RS00700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3B42_RS00705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3B42_RS00710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3B42_RS00725	COG0101	tRNA pseudouridine synthase activity
C3B42_RS00735	COG1420	regulation of RNA biosynthetic process
C3B42_RS00740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3B42_RS00745	COG0443	Heat shock 70 kDa protein
C3B42_RS00765	COG2121	Domain of unknown function (DUF374)
C3B42_RS00770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3B42_RS00780	COG0195	Participates in both transcription termination and antitermination
C3B42_RS00785	COG0215	cysteine-tRNA ligase activity
C3B42_RS00790	COG1393	Belongs to the ArsC family
C3B42_RS00795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B42_RS00800	COG0343	queuine tRNA-ribosyltransferase activity
C3B42_RS00830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3B42_RS00835	COG0557	exoribonuclease II activity
C3B42_RS00850	COG0360	Binds together with S18 to 16S ribosomal RNA
C3B42_RS00855	COG0629	single-stranded DNA binding
C3B42_RS00860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3B42_RS00865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3B42_RS00880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3B42_RS00890	COG0157	Belongs to the NadC ModD family
C3B42_RS00905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C3B42_RS00915	COG0083	homoserine kinase activity
C3B42_RS00925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3B42_RS00930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3B42_RS00935	COG0779	Required for maturation of 30S ribosomal subunits
C3B42_RS00940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3B42_RS00940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3B42_RS00945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3B42_RS00950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3B42_RS00955	COG1185	polyribonucleotide nucleotidyltransferase activity
C3B42_RS00955	COG0539	negative regulation of cytoplasmic translation
C3B42_RS00960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3B42_RS00965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3B42_RS00970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B42_RS00970	COG0072	phenylalanine-tRNA ligase activity
C3B42_RS00975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3B42_RS00980	COG0537	adenosine 5'-monophosphoramidase activity
C3B42_RS00985	COG0825	malonyl-CoA metabolic process
C3B42_RS00990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3B42_RS00995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3B42_RS01005	COG0602	queuosine metabolic process
C3B42_RS01015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C3B42_RS01035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3B42_RS01045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3B42_RS01050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3B42_RS01065	COG0356	it plays a direct role in the translocation of protons across the membrane
C3B42_RS01070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3B42_RS01075	COG0191	fructose-bisphosphate aldolase activity
C3B42_RS01085	COG0745	RESPONSE REGULATOR receiver
C3B42_RS01090	COG0642	Histidine kinase
C3B42_RS01120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3B42_RS01130	COG2199	diguanylate cyclase activity
C3B42_RS01130	COG3287	FIST C domain
C3B42_RS01130	COG2200	EAL domain
C3B42_RS01150	COG3043	anaerobic respiration
C3B42_RS01155	COG0348	domain, Protein
C3B42_RS01160	COG0437	4 iron, 4 sulfur cluster binding
C3B42_RS01165	COG0243	molybdopterin cofactor binding
C3B42_RS01180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3B42_RS01185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3B42_RS01190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3B42_RS01200	COG2404	hydrolase activity, acting on ester bonds
C3B42_RS01215	COG3721	Heme iron utilization protein
C3B42_RS01220	COG1132	(ABC) transporter
C3B42_RS01235	COG4558	Periplasmic binding protein
C3B42_RS01240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3B42_RS01245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C3B42_RS01250	COG4771	TonB-dependent receptor
C3B42_RS01255	COG4771	TonB-dependent receptor
C3B42_RS01265	COG0840	transmembrane signaling receptor activity
C3B42_RS01270	COG0840	transmembrane signaling receptor activity
C3B42_RS01295	COG2030	dehydratase
C3B42_RS01310	COG1401	restriction endodeoxyribonuclease activity
C3B42_RS01325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3B42_RS01330	COG0542	response to heat
C3B42_RS01365	COG0148	phosphopyruvate hydratase activity
C3B42_RS01380	COG2814	Major facilitator Superfamily
C3B42_RS01390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3B42_RS01395	COG0049	tRNA binding
C3B42_RS01400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3B42_RS01405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3B42_RS01410	COG0497	DNA recombination
C3B42_RS01415	COG0840	transmembrane signaling receptor activity
C3B42_RS01420	COG0826	peptidase U32
C3B42_RS01430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3B42_RS01440	COG0752	glycyl-tRNA synthetase alpha subunit
C3B42_RS01455	COG1519	Transferase
C3B42_RS01455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3B42_RS01460	COG0564	pseudouridine synthase activity
C3B42_RS01465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3B42_RS01470	COG0228	four-way junction DNA binding
C3B42_RS01475	COG1837	Belongs to the UPF0109 family
C3B42_RS01480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3B42_RS01500	COG0745	RESPONSE REGULATOR receiver
C3B42_RS01510	COG4786	Flagellar basal body rod
C3B42_RS01515	COG1815	bacterial-type flagellum-dependent cell motility
C3B42_RS01520	COG1766	The M ring may be actively involved in energy transduction
C3B42_RS01525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3B42_RS01535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3B42_RS01545	COG1749	Flagellar hook protein flgE
C3B42_RS01550	COG1749	Flagellar hook protein flgE
C3B42_RS01575	COG3951	Flagellar rod assembly protein muramidase FlgJ
C3B42_RS01590	COG1419	protein localization to endoplasmic reticulum
C3B42_RS01595	COG0455	bacterial-type flagellum organization
C3B42_RS01625	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3B42_RS01635	COG1157	protein secretion by the type III secretion system
C3B42_RS01645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3B42_RS01655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3B42_RS01670	COG3328	transposase activity
C3B42_RS01675	COG1686	Belongs to the peptidase S11 family
C3B42_RS01690	COG0840	transmembrane signaling receptor activity
C3B42_RS01705	COG0745	RESPONSE REGULATOR receiver
C3B42_RS01710	COG1639	'signal transduction protein
C3B42_RS01715	COG0840	transmembrane signaling receptor activity
C3B42_RS01720	COG2199	diguanylate cyclase activity
C3B42_RS01725	COG0840	transmembrane signaling receptor activity
C3B42_RS01730	COG0840	transmembrane signaling receptor activity
C3B42_RS01735	COG0840	transmembrane signaling receptor activity
C3B42_RS01740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3B42_RS01750	COG0336	Belongs to the RNA methyltransferase TrmD family
C3B42_RS01755	COG0335	large ribosomal subunit rRNA binding
C3B42_RS01760	COG0586	Pfam SNARE associated Golgi protein
C3B42_RS01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3B42_RS01780	COG0251	oxidation-reduction process
C3B42_RS01795	COG2199	diguanylate cyclase activity
C3B42_RS01800	COG2207	Transcriptional regulator
C3B42_RS01810	COG0300	oxidoreductase activity
C3B42_RS01825	COG3610	response to peptide
C3B42_RS01830	COG2966	Psort location CytoplasmicMembrane, score
C3B42_RS01845	COG0811	peptide transport
C3B42_RS01860	COG1971	Probably functions as a manganese efflux pump
C3B42_RS01885	COG0628	permease
C3B42_RS01895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3B42_RS01900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3B42_RS01925	COG4773	Receptor
C3B42_RS01930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3B42_RS01935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3B42_RS01945	COG0142	geranyltranstransferase activity
C3B42_RS01950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3B42_RS01955	COG0442	prolyl-tRNA aminoacylation
C3B42_RS01960	COG0668	transmembrane transport
C3B42_RS01965	COG0617	tRNA 3'-terminal CCA addition
C3B42_RS01970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3B42_RS01975	COG1862	Preprotein translocase
C3B42_RS01980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3B42_RS01985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3B42_RS02000	COG1360	Flagellar Motor Protein
C3B42_RS02005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3B42_RS02015	COG0495	leucyl-tRNA aminoacylation
C3B42_RS02025	COG0285	dihydrofolate synthase activity
C3B42_RS02050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3B42_RS02060	COG1396	sequence-specific DNA binding
C3B42_RS02130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3B42_RS02135	COG0444	Belongs to the ABC transporter superfamily
C3B42_RS02140	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3B42_RS02145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3B42_RS02175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3B42_RS02180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3B42_RS02195	COG0250	Participates in transcription elongation, termination and antitermination
C3B42_RS02200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3B42_RS02205	COG0081	regulation of translation
C3B42_RS02210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3B42_RS02215	COG0222	ribosome binding
C3B42_RS02220	COG0085	RNA polymerase activity
C3B42_RS02225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3B42_RS02245	COG0386	Belongs to the glutathione peroxidase family
C3B42_RS02250	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C3B42_RS02255	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C3B42_RS02275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C3B42_RS02280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C3B42_RS02285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C3B42_RS02290	COG2205	protein histidine kinase activity
C3B42_RS02295	COG2205	protein histidine kinase activity
C3B42_RS02300	COG0745	RESPONSE REGULATOR receiver
C3B42_RS02305	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C3B42_RS02320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3B42_RS02325	COG0298	carbon dioxide binding
C3B42_RS02330	COG0409	Hydrogenase expression formation protein
C3B42_RS02345	COG0309	Hydrogenase expression formation protein (HypE)
C3B42_RS02360	COG0310	cobalt ion transport
C3B42_RS02395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3B42_RS02405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3B42_RS02415	COG1295	ribonuclease BN
C3B42_RS02420	COG0277	FAD linked oxidase domain protein
C3B42_RS02430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3B42_RS02435	COG2226	methyltransferase
C3B42_RS02440	COG0196	riboflavin kinase activity
C3B42_RS02465	COG1739	Uncharacterized protein family UPF0029
C3B42_RS02490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3B42_RS02560	COG1696	Membrane protein involved in D-alanine export
C3B42_RS02575	COG1696	Membrane protein involved in D-alanine export
C3B42_RS02605	COG0463	Glycosyl transferase, family 2
C3B42_RS02605	COG1216	Glycosyl transferase, family 2
C3B42_RS02615	COG0438	transferase activity, transferring glycosyl groups
C3B42_RS02640	COG0859	PFAM glycosyl transferase family 9
C3B42_RS02655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C3B42_RS02660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3B42_RS02660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3B42_RS02665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3B42_RS02670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C3B42_RS02680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3B42_RS02690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3B42_RS02705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3B42_RS02715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3B42_RS02760	COG1136	(ABC) transporter
C3B42_RS02785	COG1408	metallophosphoesterase
C3B42_RS02800	COG1121	(ABC) transporter
C3B42_RS02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3B42_RS02815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3B42_RS02835	COG0525	valine-tRNA ligase activity
C3B42_RS02865	COG2814	Major facilitator Superfamily
C3B42_RS02870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3B42_RS02890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3B42_RS02900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3B42_RS02905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3B42_RS02915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B42_RS02935	COG0439	Biotin carboxylase
C3B42_RS02945	COG2166	iron-sulfur cluster assembly
C3B42_RS02950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3B42_RS02960	COG0396	ATPase activity
C3B42_RS02965	COG0719	Fe-S assembly protein
C3B42_RS02980	COG3706	GGDEF domain
C3B42_RS02985	COG0165	Argininosuccinate lyase
C3B42_RS02990	COG0556	nucleotide-excision repair
C3B42_RS03000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3B42_RS03005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3B42_RS03010	COG0784	Response regulator, receiver
C3B42_RS03010	COG0835	chemotaxis
C3B42_RS03020	COG0582	viral genome integration into host DNA
C3B42_RS03110	COG3328	transposase activity
C3B42_RS03115	COG3177	Filamentation induced by cAMP protein fic
C3B42_RS03155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3B42_RS03160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C3B42_RS03165	COG0585	pseudouridine synthase activity
C3B42_RS03175	COG0840	transmembrane signaling receptor activity
C3B42_RS03180	COG0632	four-way junction helicase activity
C3B42_RS03185	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3B42_RS03195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3B42_RS03305	COG0284	orotidine-5'-phosphate decarboxylase activity
C3B42_RS03310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3B42_RS03315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3B42_RS03330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3B42_RS03330	COG0189	ligase activity
C3B42_RS03345	COG0784	Response regulator, receiver
C3B42_RS03345	COG2205	protein histidine kinase activity
C3B42_RS03350	COG2205	protein histidine kinase activity
C3B42_RS03355	COG0174	glutamine synthetase
C3B42_RS03365	COG0314	molybdopterin synthase activity
C3B42_RS03375	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C3B42_RS03380	COG1968	undecaprenyl-diphosphatase activity
C3B42_RS03415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3B42_RS03465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3B42_RS03470	COG0772	Belongs to the SEDS family
C3B42_RS03475	COG0768	penicillin binding
C3B42_RS03480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3B42_RS03485	COG1858	cytochrome C peroxidase
C3B42_RS03515	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B42_RS03530	COG1116	anion transmembrane transporter activity
C3B42_RS03535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3B42_RS03550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3B42_RS03560	COG2204	response regulator
C3B42_RS03570	COG5001	Diguanylate cyclase
C3B42_RS03570	COG2203	Gaf domain
C3B42_RS03570	COG3706	GGDEF domain
C3B42_RS03570	COG4251	negative regulation of phosphorylation
C3B42_RS03585	COG0745	RESPONSE REGULATOR receiver
C3B42_RS03590	COG0642	Histidine kinase
C3B42_RS03595	COG2081	HI0933 family
C3B42_RS03600	COG0840	transmembrane signaling receptor activity
C3B42_RS03610	COG3920	Histidine kinase
C3B42_RS03615	COG5002	protein histidine kinase activity
C3B42_RS03620	COG1692	metallophosphoesterase
C3B42_RS03640	COG1570	exodeoxyribonuclease VII activity
C3B42_RS03645	COG0835	chemotaxis
C3B42_RS03655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3B42_RS03660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3B42_RS03670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3B42_RS03675	COG0459	protein refolding
C3B42_RS03680	COG1686	Belongs to the peptidase S11 family
C3B42_RS03695	COG0848	biopolymer transport protein
C3B42_RS03700	COG0811	peptide transport
C3B42_RS03715	COG0577	efflux transmembrane transporter activity
C3B42_RS03715	COG1136	(ABC) transporter
C3B42_RS03720	COG1136	(ABC) transporter
C3B42_RS03720	COG0577	efflux transmembrane transporter activity
C3B42_RS03725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3B42_RS03730	COG0542	response to heat
C3B42_RS03735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3B42_RS03745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3B42_RS03750	COG0706	membrane insertase activity
C3B42_RS03760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3B42_RS03780	COG3706	GGDEF domain
C3B42_RS03790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3B42_RS03795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C3B42_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3B42_RS03815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3B42_RS03830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3B42_RS03835	COG0305	Participates in initiation and elongation during chromosome replication
C3B42_RS03855	COG4771	TonB-dependent receptor
C3B42_RS03860	COG4771	TonB-dependent receptor
C3B42_RS03880	COG2819	hydrolase of the alpha beta superfamily
C3B42_RS03885	COG0500	methyltransferase
C3B42_RS03905	COG1966	Carbon starvation protein
C3B42_RS03915	COG0563	adenylate kinase activity
C3B42_RS03925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3B42_RS03930	COG2207	Transcriptional regulator
C3B42_RS03960	COG1979	alcohol dehydrogenase
C3B42_RS03965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3B42_RS03970	COG0322	excinuclease ABC activity
C3B42_RS03975	COG0840	transmembrane signaling receptor activity
C3B42_RS04000	COG0745	RESPONSE REGULATOR receiver
C3B42_RS04010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3B42_RS04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3B42_RS04035	COG3437	response regulator, receiver
C3B42_RS04035	COG0784	Response regulator, receiver
C3B42_RS04040	COG1338	Plays a role in the flagellum-specific transport system
C3B42_RS04045	COG0768	penicillin binding
C3B42_RS04065	COG2884	Cell division ATP-binding protein ftsE
C3B42_RS04070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3B42_RS04080	COG0564	pseudouridine synthase activity
C3B42_RS04085	COG0772	Belongs to the SEDS family
C3B42_RS04095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3B42_RS04100	COG3123	guanosine phosphorylase activity
C3B42_RS04180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3B42_RS04185	COG0475	glutathione-regulated potassium exporter activity
C3B42_RS04185	COG0569	domain protein
C3B42_RS04190	COG0210	DNA helicase
C3B42_RS04195	COG0709	Synthesizes selenophosphate from selenide and ATP
C3B42_RS04200	COG1305	Transglutaminase-like
C3B42_RS04220	COG2204	response regulator
C3B42_RS04255	COG0243	molybdopterin cofactor binding
C3B42_RS04255	COG3383	formate dehydrogenase (NAD+) activity
C3B42_RS04260	COG0437	4 iron, 4 sulfur cluster binding
C3B42_RS04270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3B42_RS04275	COG1104	cysteine desulfurase activity
C3B42_RS04280	COG0303	'Molybdopterin
C3B42_RS04290	COG2814	Major facilitator Superfamily
C3B42_RS04300	COG2354	Protein conserved in bacteria
C3B42_RS04305	COG0726	polysaccharide deacetylase
C3B42_RS04315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3B42_RS04340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3B42_RS04345	COG2171	N-acyltransferase activity
C3B42_RS04350	COG1944	ATP diphosphatase activity
C3B42_RS04355	COG2169	Transcriptional regulator
C3B42_RS04355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3B42_RS04360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3B42_RS04405	COG0628	permease
C3B42_RS04410	COG2255	four-way junction helicase activity
C3B42_RS04415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3B42_RS04420	COG0159	tryptophan synthase activity
C3B42_RS04425	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C3B42_RS04435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3B42_RS04440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3B42_RS04455	COG0137	argininosuccinate synthase activity
C3B42_RS04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3B42_RS04465	COG0742	ribosomal rna small subunit methyltransferase
C3B42_RS04470	COG1418	mRNA catabolic process
C3B42_RS04485	COG0552	protein localization to endoplasmic reticulum
C3B42_RS04505	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3B42_RS04510	COG0778	Nitroreductase
C3B42_RS04520	COG0488	(ABC) transporter
C3B42_RS04525	COG1607	acyl-coa hydrolase
C3B42_RS04530	COG0840	transmembrane signaling receptor activity
C3B42_RS04540	COG0484	heat shock protein binding
C3B42_RS04545	COG0484	heat shock protein binding
C3B42_RS04560	COG0300	oxidoreductase activity
C3B42_RS04570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3B42_RS04575	COG0802	atpase or kinase
C3B42_RS04580	COG1137	ATPase activity
C3B42_RS04585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C3B42_RS04595	COG2201	protein-glutamate methylesterase activity
C3B42_RS04610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3B42_RS04645	COG2076	Multidrug Resistance protein
C3B42_RS04650	COG0642	Histidine kinase
C3B42_RS04665	COG3258	Cytochrome c
C3B42_RS04675	COG1049	propionate catabolic process, 2-methylcitrate cycle
C3B42_RS04680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C3B42_RS04685	COG2363	Small membrane protein
C3B42_RS04690	COG1666	GTP binding
C3B42_RS04745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C3B42_RS04760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B42_RS04760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3B42_RS04770	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C3B42_RS04795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3B42_RS04800	COG0612	Peptidase, M16
C3B42_RS04805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3B42_RS04810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3B42_RS04815	COG0287	Prephenate dehydrogenase
C3B42_RS04830	COG0243	molybdopterin cofactor binding
C3B42_RS04840	COG1921	L-seryl-tRNASec selenium transferase activity
C3B42_RS04955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3B42_RS04960	COG0135	phosphoribosylanthranilate isomerase activity
C3B42_RS04965	COG2176	DNA-directed DNA polymerase activity
C3B42_RS04975	COG1013	pyruvate-flavodoxin oxidoreductase activity
C3B42_RS04980	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3B42_RS04980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3B42_RS04990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3B42_RS04995	COG0727	PFAM Uncharacterised protein family (UPF0153)
C3B42_RS05005	COG0134	indole-3-glycerol-phosphate synthase activity
C3B42_RS05010	COG0583	DNA-binding transcription factor activity
C3B42_RS05015	COG1942	4-Oxalocrotonate Tautomerase
C3B42_RS05020	COG2199	diguanylate cyclase activity
C3B42_RS05030	COG0739	heme binding
C3B42_RS05035	COG1610	YqeY-like protein
C3B42_RS05040	COG0488	(ABC) transporter
C3B42_RS05045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3B42_RS05065	COG0667	Aldo Keto reductase
C3B42_RS05070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B42_RS05075	COG0805	protein transport
C3B42_RS05080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3B42_RS05090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C3B42_RS05105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3B42_RS05115	COG1663	tetraacyldisaccharide 4'-kinase activity
C3B42_RS05120	COG0861	Integral membrane protein TerC family
C3B42_RS05125	COG0789	Transcriptional regulator
C3B42_RS05130	COG0484	heat shock protein binding
C3B42_RS05135	COG4191	Histidine kinase
C3B42_RS05145	COG2201	protein-glutamate methylesterase activity
C3B42_RS05165	COG0776	regulation of translation
C3B42_RS05175	COG0275	rRNA processing
C3B42_RS05205	COG0039	L-malate dehydrogenase activity
C3B42_RS05215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3B42_RS05225	COG1193	negative regulation of DNA recombination
C3B42_RS05230	COG1253	flavin adenine dinucleotide binding
C3B42_RS05240	COG1119	ATPase activity
C3B42_RS05250	COG2258	MOSC domain
C3B42_RS05255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3B42_RS05265	COG3135	benzoate transporter
C3B42_RS05275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3B42_RS05280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3B42_RS05315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B42_RS05315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3B42_RS05330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3B42_RS05345	COG0527	aspartate kinase activity
C3B42_RS05350	COG0494	nUDIX hydrolase
C3B42_RS05355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3B42_RS05360	COG2890	protein-(glutamine-N5) methyltransferase activity
C3B42_RS05365	COG0339	signal peptide processing
C3B42_RS05385	COG2203	Gaf domain
C3B42_RS05385	COG3706	GGDEF domain
C3B42_RS05385	COG4251	negative regulation of phosphorylation
C3B42_RS05385	COG5001	Diguanylate cyclase
C3B42_RS05390	COG0824	Thioesterase
C3B42_RS05395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3B42_RS05400	COG0501	Belongs to the peptidase M48B family
C3B42_RS05410	COG2321	neutral zinc metallopeptidase
C3B42_RS05430	COG0037	tRNA processing
C3B42_RS05465	COG0028	Belongs to the TPP enzyme family
C3B42_RS05470	COG0440	acetolactate synthase activity
C3B42_RS05475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3B42_RS05480	COG1196	nuclear chromosome segregation
C3B42_RS05480	COG1674	ftsk spoiiie
C3B42_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
C3B42_RS05495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3B42_RS05500	COG1160	GTP binding
C3B42_RS05505	COG0659	secondary active sulfate transmembrane transporter activity
C3B42_RS05525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C3B42_RS05535	COG1185	polyribonucleotide nucleotidyltransferase activity
C3B42_RS05540	COG0745	RESPONSE REGULATOR receiver
C3B42_RS05545	COG2198	Histidine kinase
C3B42_RS05545	COG0643	Histidine kinase
C3B42_RS05550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3B42_RS05560	COG2201	protein-glutamate methylesterase activity
C3B42_RS05565	COG0582	viral genome integration into host DNA
C3B42_RS05570	COG0484	heat shock protein binding
C3B42_RS05595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3B42_RS05605	COG4251	negative regulation of phosphorylation
C3B42_RS05605	COG3706	GGDEF domain
C3B42_RS05605	COG2203	Gaf domain
C3B42_RS05605	COG5001	Diguanylate cyclase
C3B42_RS05610	COG0500	methyltransferase
C3B42_RS05620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3B42_RS05620	COG1333	cytochrome c biogenesis protein
C3B42_RS05625	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3B42_RS05640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3B42_RS05645	COG0653	protein targeting
C3B42_RS05655	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3B42_RS05665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B42_RS05670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3B42_RS05685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3B42_RS05715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3B42_RS05720	COG4771	TonB-dependent receptor
C3B42_RS05750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3B42_RS05775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C3B42_RS05785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3B42_RS05785	COG0475	glutathione-regulated potassium exporter activity
C3B42_RS05825	COG1451	nucleotide metabolic process
C3B42_RS05835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3B42_RS05840	COG0519	Catalyzes the synthesis of GMP from XMP
C3B42_RS05840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3B42_RS05865	COG3328	transposase activity
C3B42_RS05885	COG0596	Alpha beta hydrolase
C3B42_RS05900	COG2199	diguanylate cyclase activity
C3B42_RS05900	COG2200	EAL domain
C3B42_RS05900	COG3287	FIST C domain
C3B42_RS05905	COG5002	protein histidine kinase activity
C3B42_RS05905	COG5001	Diguanylate cyclase
C3B42_RS05910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3B42_RS05915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3B42_RS05930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3B42_RS05935	COG3177	Filamentation induced by cAMP protein fic
C3B42_RS05955	COG0415	Belongs to the DNA photolyase family
C3B42_RS05960	COG1090	epimerase
C3B42_RS05970	COG3040	lipid binding
C3B42_RS05975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3B42_RS05980	COG3046	protein related to deoxyribodipyrimidine photolyase
C3B42_RS05995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3B42_RS06005	COG2200	EAL domain
C3B42_RS06015	COG3275	phosphorelay sensor kinase activity
C3B42_RS06040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3B42_RS06040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3B42_RS06045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3B42_RS06055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3B42_RS06060	COG0735	belongs to the Fur family
C3B42_RS06070	COG0728	peptidoglycan biosynthetic process
C3B42_RS06075	COG1132	(ABC) transporter
C3B42_RS06080	COG0167	dihydroorotate dehydrogenase activity
C3B42_RS06085	COG0612	Peptidase, M16
C3B42_RS06090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3B42_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
C3B42_RS06100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3B42_RS06105	COG0750	zinc metalloprotease
C3B42_RS06110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3B42_RS06120	COG0840	transmembrane signaling receptor activity
C3B42_RS06130	COG0642	Histidine kinase
C3B42_RS06135	COG0745	RESPONSE REGULATOR receiver
C3B42_RS06150	COG0217	transcriptional regulatory protein
C3B42_RS06170	COG1611	Belongs to the LOG family
C3B42_RS06175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3B42_RS06190	COG3328	transposase activity
C3B42_RS06200	COG0351	phosphomethylpyrimidine kinase
C3B42_RS06205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3B42_RS06220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3B42_RS06250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3B42_RS06255	COG1696	Membrane protein involved in D-alanine export
C3B42_RS06270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3B42_RS06295	COG5002	protein histidine kinase activity
C3B42_RS06325	COG1114	Component of the transport system for branched-chain amino acids
C3B42_RS06330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3B42_RS06335	COG0788	formyltetrahydrofolate deformylase activity
C3B42_RS06340	COG1496	oxidoreductase activity
C3B42_RS06345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3B42_RS06350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3B42_RS06360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3B42_RS06390	COG0513	Belongs to the DEAD box helicase family
C3B42_RS06400	COG0754	glutathionylspermidine amidase activity
C3B42_RS06405	COG0840	transmembrane signaling receptor activity
C3B42_RS06410	COG0840	transmembrane signaling receptor activity
C3B42_RS06420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3B42_RS06425	COG3328	transposase activity
C3B42_RS06430	COG0516	GMP reductase activity
C3B42_RS06430	COG0517	IMP dehydrogenase activity
C3B42_RS06435	COG0154	amidase activity
C3B42_RS06440	COG0203	ribosomal protein L17
C3B42_RS06445	COG0202	RNA polymerase activity
C3B42_RS06450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3B42_RS06455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3B42_RS06460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3B42_RS06465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3B42_RS06480	COG0473	3-isopropylmalate dehydrogenase activity
C3B42_RS06485	COG0066	3-isopropylmalate dehydratase activity
C3B42_RS06490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3B42_RS06495	COG0751	glycine-tRNA ligase activity
C3B42_RS06515	COG0357	Ribosomal RNA small subunit methyltransferase G
C3B42_RS06520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3B42_RS06525	COG0113	porphobilinogen synthase activity
C3B42_RS06555	COG1671	Belongs to the UPF0178 family
C3B42_RS06570	COG0166	Belongs to the GPI family
C3B42_RS06590	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3B42_RS06600	COG1086	Polysaccharide biosynthesis protein
C3B42_RS06605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3B42_RS06610	COG0110	maltose O-acetyltransferase activity
C3B42_RS06615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3B42_RS06630	COG0438	transferase activity, transferring glycosyl groups
C3B42_RS06635	COG1132	(ABC) transporter
C3B42_RS06665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3B42_RS06670	COG0367	asparagine synthase
C3B42_RS06675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3B42_RS06680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3B42_RS06685	COG0579	oxidoreductase
C3B42_RS06705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3B42_RS06730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3B42_RS06740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3B42_RS06750	COG2391	methyltransferase activity
C3B42_RS06755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3B42_RS06760	COG0849	cell division
C3B42_RS06770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3B42_RS06790	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3B42_RS06795	COG0488	(ABC) transporter
C3B42_RS06800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3B42_RS06810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3B42_RS06815	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3B42_RS06820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3B42_RS06830	COG2217	Heavy metal translocating P-type atpase
C3B42_RS06835	COG0513	Belongs to the DEAD box helicase family
C3B42_RS06850	COG0840	transmembrane signaling receptor activity
C3B42_RS06855	COG0328	RNA-DNA hybrid ribonuclease activity
C3B42_RS06860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3B42_RS06870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3B42_RS06880	COG0456	acetyltransferase
C3B42_RS06885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3B42_RS06900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C3B42_RS06905	COG0131	Imidazoleglycerol-phosphate dehydratase
C3B42_RS06910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3B42_RS06920	COG0084	hydrolase, TatD family'
C3B42_RS06930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C3B42_RS06935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C3B42_RS06940	COG0359	binds to the 23S rRNA
C3B42_RS06950	COG0163	prenyltransferase activity
C3B42_RS06955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3B42_RS06960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3B42_RS06965	COG0124	histidyl-tRNA synthetase
C3B42_RS06970	COG1166	arginine decarboxylase activity
C3B42_RS06975	COG1045	serine acetyltransferase
C3B42_RS06980	COG0730	response to heat
C3B42_RS07010	COG1639	'signal transduction protein
C3B42_RS07015	COG0012	GTP binding
C3B42_RS07085	COG3328	transposase activity
C3B42_RS07185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3B42_RS07195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3B42_RS07265	COG1696	Membrane protein involved in D-alanine export
C3B42_RS07275	COG2855	membrane
C3B42_RS07280	COG0583	DNA-binding transcription factor activity
C3B42_RS07285	COG0500	methyltransferase
C3B42_RS07295	COG2267	carboxylic ester hydrolase activity
C3B42_RS07310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3B42_RS07315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3B42_RS07320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3B42_RS07340	COG2986	histidine ammonia-lyase
C3B42_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
C3B42_RS07370	COG1131	(ABC) transporter
C3B42_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3B42_RS07405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B42_RS07420	COG1032	radical SAM domain protein
C3B42_RS07425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3B42_RS07435	COG1573	uracil-dna glycosylase
C3B42_RS07440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3B42_RS07445	COG0024	Methionine aminopeptidase
C3B42_RS07450	COG0201	protein transport
C3B42_RS07455	COG0200	Binds to the 23S rRNA
C3B42_RS07460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3B42_RS07465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3B42_RS07470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3B42_RS07475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3B42_RS07480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3B42_RS07485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3B42_RS07490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3B42_RS07495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3B42_RS07500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3B42_RS07505	COG0255	Belongs to the universal ribosomal protein uL29 family
C3B42_RS07510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3B42_RS07515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3B42_RS07520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3B42_RS07525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3B42_RS07530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3B42_RS07535	COG0089	rRNA binding
C3B42_RS07540	COG0088	Forms part of the polypeptide exit tunnel
C3B42_RS07545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3B42_RS07550	COG0051	transcription antitermination factor activity, RNA binding
C3B42_RS07570	COG0708	Exodeoxyribonuclease III
C3B42_RS07575	COG0301	tRNA thio-modification
C3B42_RS07575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3B42_RS07595	COG0606	chelatase, subunit chli
C3B42_RS07600	COG0840	transmembrane signaling receptor activity
C3B42_RS07605	COG0840	transmembrane signaling receptor activity
C3B42_RS07615	COG0242	peptide deformylase activity
C3B42_RS07620	COG0740	serine-type endopeptidase activity
C3B42_RS07625	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3B42_RS07630	COG2326	polyphosphate kinase activity
C3B42_RS07655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C3B42_RS07660	COG1355	regulation of microtubule-based process
C3B42_RS07680	COG3256	nitric oxide reductase
C3B42_RS07690	COG2010	Cytochrome c
C3B42_RS07695	COG2010	Cytochrome c
C3B42_RS07700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3B42_RS07710	COG0535	radical SAM domain protein
C3B42_RS07720	COG1648	precorrin-2 dehydrogenase activity
C3B42_RS07720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3B42_RS07730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3B42_RS07730	COG1648	precorrin-2 dehydrogenase activity
C3B42_RS07735	COG1522	sequence-specific DNA binding
C3B42_RS07750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3B42_RS07760	COG1278	Cold shock
C3B42_RS07775	COG2217	Heavy metal translocating P-type atpase
C3B42_RS07785	COG0194	GDP metabolic process
C3B42_RS07795	COG1136	(ABC) transporter
C3B42_RS07800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3B42_RS07805	COG0052	Belongs to the universal ribosomal protein uS2 family
C3B42_RS07810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3B42_RS07825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3B42_RS07830	COG0579	oxidoreductase
C3B42_RS07835	COG1058	Belongs to the CinA family
C3B42_RS07835	COG1546	Belongs to the CinA family
C3B42_RS07885	COG0745	RESPONSE REGULATOR receiver
C3B42_RS07895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3B42_RS07905	COG2176	DNA-directed DNA polymerase activity
C3B42_RS07945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3B42_RS07950	COG0280	phosphate acetyltransferase
C3B42_RS07960	COG0616	signal peptide processing
C3B42_RS07965	COG0402	S-adenosylhomocysteine deaminase activity
C3B42_RS07970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3B42_RS07975	COG0006	proline dipeptidase activity
C3B42_RS07980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3B42_RS07985	COG0482	sulfurtransferase activity
C3B42_RS07990	COG0482	sulfurtransferase activity
C3B42_RS08000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3B42_RS08010	COG0481	GTPase activity
C3B42_RS08025	COG3328	transposase activity
C3B42_RS08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3B42_RS08045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3B42_RS08065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3B42_RS08080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3B42_RS08085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3B42_RS08090	COG2264	protein methyltransferase activity
C3B42_RS08095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3B42_RS08105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3B42_RS08115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3B42_RS08120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3B42_RS08125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3B42_RS08140	COG0840	transmembrane signaling receptor activity
C3B42_RS08180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3B42_RS08190	COG0133	tryptophan synthase activity
C3B42_RS08195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3B42_RS08200	COG1793	dna ligase
C3B42_RS08210	COG0626	cystathionine gamma-synthase activity
C3B42_RS08240	COG0745	RESPONSE REGULATOR receiver
C3B42_RS08280	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C3B42_RS08295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3B42_RS08335	COG0528	UMP kinase activity
C3B42_RS08340	COG1758	RNA polymerase activity
C3B42_RS08345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3B42_RS08350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3B42_RS08360	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3B42_RS08375	COG0193	aminoacyl-tRNA hydrolase activity
C3B42_RS08380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3B42_RS08385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3B42_RS08390	COG0681	Belongs to the peptidase S26 family
C3B42_RS08395	COG0698	ribose 5-phosphate isomerase
C3B42_RS08435	COG3287	FIST C domain
C3B42_RS08435	COG2200	EAL domain
C3B42_RS08435	COG2199	diguanylate cyclase activity
C3B42_RS08440	COG0259	pyridoxamine-phosphate oxidase activity
C3B42_RS08445	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3B42_RS08450	COG3328	transposase activity
C3B42_RS08460	COG0513	Belongs to the DEAD box helicase family
C3B42_RS08480	COG0326	Molecular chaperone. Has ATPase activity
C3B42_RS08485	COG4251	negative regulation of phosphorylation
C3B42_RS08485	COG3706	GGDEF domain
C3B42_RS08485	COG2203	Gaf domain
C3B42_RS08485	COG5001	Diguanylate cyclase
C3B42_RS08490	COG2205	protein histidine kinase activity
C3B42_RS08490	COG3850	Histidine kinase
C3B42_RS08490	COG4999	Histidine kinase
C3B42_RS08490	COG3437	response regulator, receiver
C3B42_RS08500	COG0010	Belongs to the arginase family
C3B42_RS08505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3B42_RS08510	COG0581	inorganic phosphate transmembrane transporter activity
C3B42_RS08515	COG0573	inorganic phosphate transmembrane transporter activity
C3B42_RS08520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3B42_RS08530	COG4335	DNA alkylation repair
C3B42_RS08535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3B42_RS08545	COG2264	protein methyltransferase activity
C3B42_RS08570	COG2995	paraquat-inducible protein a
C3B42_RS08575	COG3008	intermembrane lipid transfer
C3B42_RS08580	COG0753	catalase activity
C3B42_RS08595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3B42_RS08600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3B42_RS08610	COG0668	transmembrane transport
C3B42_RS08615	COG1227	inorganic diphosphatase activity
C3B42_RS08620	COG3012	SEC-C Motif Domain Protein
C3B42_RS08640	COG1027	Aspartate ammonia-lyase
C3B42_RS08645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3B42_RS08650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3B42_RS08655	COG1047	Peptidyl-prolyl cis-trans
C3B42_RS08670	COG0823	Involved in the tonB-independent uptake of proteins
C3B42_RS08680	COG0848	biopolymer transport protein
C3B42_RS08685	COG0811	peptide transport
C3B42_RS08690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3B42_RS08695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3B42_RS08700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3B42_RS08705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3B42_RS08710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3B42_RS08715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3B42_RS08725	COG1475	DNA binding
C3B42_RS08730	COG1192	Involved in chromosome partitioning
C3B42_RS08745	COG0840	transmembrane signaling receptor activity
C3B42_RS08750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3B42_RS08755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3B42_RS08760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3B42_RS08765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3B42_RS08770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3B42_RS08790	COG0358	DNA primase activity
C3B42_RS08800	COG0571	ribonuclease III activity
C3B42_RS08805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3B42_RS08815	COG2326	polyphosphate kinase activity
C3B42_RS08830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3B42_RS08855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3B42_RS08865	COG1196	nuclear chromosome segregation
C3B42_RS08865	COG0741	lytic transglycosylase activity
C3B42_RS08865	COG0739	heme binding
C3B42_RS08885	COG2183	response to ionizing radiation
C3B42_RS08890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3B42_RS08895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3B42_RS08900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3B42_RS08905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3B42_RS08905	COG0649	NAD binding
C3B42_RS08910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C3B42_RS08920	COG0372	Belongs to the citrate synthase family
C3B42_RS08930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3B42_RS08935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3B42_RS08940	COG0839	Belongs to the complex I subunit 6 family
C3B42_RS08945	COG0713	ATP synthesis coupled electron transport
C3B42_RS08950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3B42_RS08960	COG1007	ATP synthesis coupled electron transport
C3B42_RS08970	COG1053	succinate dehydrogenase
C3B42_RS08975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3B42_RS08995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3B42_RS09000	COG0416	fatty acid biosynthetic process
C3B42_RS09005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3B42_RS09015	COG0105	UTP biosynthetic process
C3B42_RS09025	COG0450	alkyl hydroperoxide reductase
C3B42_RS09030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3B42_RS09035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3B42_RS09040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3B42_RS09045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3B42_RS09055	COG0181	hydroxymethylbilane synthase activity
C3B42_RS09060	COG1335	isochorismatase
C3B42_RS09100	COG3278	Belongs to the heme-copper respiratory oxidase family
C3B42_RS09105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3B42_RS09110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3B42_RS09115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3B42_RS09130	COG1242	4 iron, 4 sulfur cluster binding
C3B42_RS09135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3B42_RS09140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3B42_RS09145	COG0492	ferredoxin-NADP+ reductase activity
C3B42_RS09150	COG3118	belongs to the thioredoxin family
C3B42_RS09155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3B42_RS09180	COG0642	Histidine kinase
C3B42_RS09185	COG0745	RESPONSE REGULATOR receiver
C3B42_RS09195	COG0129	dihydroxy-acid dehydratase activity
C3B42_RS09225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3B42_RS09245	COG0585	pseudouridine synthase activity
C3B42_RS09260	COG0793	Belongs to the peptidase S41A family
C3B42_RS09265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3B42_RS09270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3B42_RS09275	COG0047	phosphoribosylformylglycinamidine synthase activity
C3B42_RS09285	COG0204	Acyl-transferase
C3B42_RS09290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3B42_RS09295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B42_RS09300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3B42_RS09305	COG0018	arginyl-trna synthetase
C3B42_RS09315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3B42_RS09320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3B42_RS09325	COG0126	phosphoglycerate kinase activity
C3B42_RS09330	COG0149	triose-phosphate isomerase activity
C3B42_RS09335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3B42_RS09340	COG0019	diaminopimelate decarboxylase activity
C3B42_RS09345	COG1605	Chorismate mutase
C3B42_RS09345	COG0077	Prephenate dehydratase
C3B42_RS09350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3B42_RS09355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3B42_RS09370	COG0424	maF-like protein
C3B42_RS09380	COG0791	NLP P60 protein
C3B42_RS09405	COG3118	belongs to the thioredoxin family
C3B42_RS09410	COG0189	ligase activity
C3B42_RS09425	COG2200	EAL domain
C3B42_RS09425	COG2199	diguanylate cyclase activity
C3B42_RS09425	COG3287	FIST C domain
C3B42_RS09430	COG0688	phosphatidylethanolamine metabolic process
C3B42_RS09440	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3B42_RS09450	COG0288	reversible hydration of carbon dioxide
C3B42_RS09455	COG0156	8-amino-7-oxononanoate synthase activity
C3B42_RS09460	COG0792	nuclease activity
C3B42_RS09480	COG5002	protein histidine kinase activity
C3B42_RS09485	COG0745	RESPONSE REGULATOR receiver
C3B42_RS09535	COG1987	bacterial-type flagellum assembly
C3B42_RS09545	COG1706	bacterial-type flagellum-dependent cell motility
C3B42_RS09565	COG0004	ammonium transporteR
C3B42_RS09570	COG0666	response to abiotic stimulus
C3B42_RS09575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3B42_RS09600	COG1742	UPF0060 membrane protein
C3B42_RS09610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3B42_RS09620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3B42_RS09635	COG0840	transmembrane signaling receptor activity
C3B42_RS09640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3B42_RS09685	COG2022	thiamine diphosphate biosynthetic process
C3B42_RS09690	COG1324	tolerance protein
C3B42_RS09695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3B42_RS09695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3B42_RS09705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3B42_RS09720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3B42_RS09725	COG0575	Belongs to the CDS family
C3B42_RS09750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3B42_RS09755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3B42_RS09760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3B42_RS09765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3B42_RS09775	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3B42_RS09780	COG0746	molybdenum cofactor guanylyltransferase activity
C3B42_RS09785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3B42_RS09790	COG1393	Belongs to the ArsC family
C3B42_RS09795	COG2828	Protein conserved in bacteria
C3B42_RS09800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3B42_RS09810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C3B42_RS09820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3B42_RS09825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3B42_RS09830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3B42_RS09835	COG0560	Phosphoserine phosphatase
C3B42_RS09845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3B42_RS09850	COG0786	glutamate:sodium symporter activity
C3B42_RS09865	COG0736	holo-[acyl-carrier-protein] synthase activity
C3B42_RS09870	COG0601	transmembrane transport
C3B42_RS09875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3B42_RS09900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3B42_RS09940	COG2824	Alkylphosphonate utilization operon protein PhnA
C3B42_RS09945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3B42_RS09955	COG0573	inorganic phosphate transmembrane transporter activity
C3B42_RS09960	COG0581	inorganic phosphate transmembrane transporter activity
C3B42_RS09965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3B42_RS09970	COG0704	Plays a role in the regulation of phosphate uptake
C3B42_RS09980	COG0745	RESPONSE REGULATOR receiver
C3B42_RS09985	COG5002	protein histidine kinase activity
C3B42_RS09990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3B42_RS09995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3B42_RS10000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3B42_RS10040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3B42_RS10055	COG1854	S-ribosylhomocysteine lyase activity
C3B42_RS10065	COG1686	Belongs to the peptidase S11 family
C3B42_RS10075	COG5002	protein histidine kinase activity
C3B42_RS10115	COG1410	methionine synthase
C3B42_RS10115	COG0646	methionine synthase
C3B42_RS10140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3B42_RS10140	COG0140	phosphoribosyl-ATP diphosphatase activity
C3B42_RS10155	COG0456	acetyltransferase
C3B42_RS10160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3B42_RS10165	COG1917	Cupin 2, conserved barrel domain protein
C3B42_RS10170	COG0489	protein tyrosine kinase activity
C3B42_RS10175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3B42_RS10185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3B42_RS10185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3B42_RS10195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3B42_RS10200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3B42_RS10205	COG0268	Binds directly to 16S ribosomal RNA
C3B42_RS10210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3B42_RS10215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3B42_RS10220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3B42_RS10230	COG0540	Belongs to the ATCase OTCase family
C3B42_RS10235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3B42_RS10240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3B42_RS10245	COG0505	Belongs to the CarA family
C3B42_RS10255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3B42_RS10260	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3B42_RS10265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3B42_RS10295	COG4895	conserved protein (DUF2196)
C3B42_RS10300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3B42_RS10310	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3B42_RS10315	COG0745	RESPONSE REGULATOR receiver
C3B42_RS10320	COG3852	Histidine kinase
C3B42_RS10325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3B42_RS10330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3B42_RS10335	COG0237	dephospho-CoA kinase activity
C3B42_RS10345	COG0348	domain, Protein
C3B42_RS10350	COG0504	CTP synthase activity
C3B42_RS10355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3B42_RS10355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3B42_RS10370	COG0693	protein deglycase activity
C3B42_RS10375	COG0587	DNA-directed DNA polymerase activity
C3B42_RS10380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C3B42_RS10395	COG0315	cyclic pyranopterin monophosphate synthase activity
C3B42_RS10400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3B42_RS10405	COG0428	transporter
C3B42_RS10465	COG0109	protoheme IX farnesyltransferase activity
C3B42_RS10475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3B42_RS10480	COG0254	rRNA binding
C3B42_RS10485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3B42_RS10490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3B42_RS10500	COG0436	Aminotransferase
C3B42_RS10505	COG0460	homoserine dehydrogenase
C3B42_RS10510	COG0564	pseudouridine synthase activity
C3B42_RS10515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3B42_RS10520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B42_RS10525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3B42_RS10530	COG2885	chlorophyll binding
C3B42_RS10530	COG3047	cAMP biosynthetic process
C3B42_RS10540	COG4206	TonB-dependent receptor
C3B42_RS10555	COG0745	RESPONSE REGULATOR receiver
C3B42_RS10575	COG0604	alcohol dehydrogenase
C3B42_RS10580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3B42_RS10585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3B42_RS10595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3B42_RS10595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3B42_RS10600	COG0511	ligase activity, forming carbon-carbon bonds
C3B42_RS10605	COG0439	Biotin carboxylase
C3B42_RS10610	COG0513	Belongs to the DEAD box helicase family
C3B42_RS10615	COG1278	Cold shock
C3B42_RS10630	COG0306	phosphate transporter
C3B42_RS10640	COG0367	asparagine synthase
C3B42_RS10660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3B42_RS10665	COG1981	membrane
C3B42_RS10670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3B42_RS10670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C3B42_RS10675	COG1187	pseudouridine synthase activity
C3B42_RS10680	COG0517	IMP dehydrogenase activity
C3B42_RS10680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3B42_RS10685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3B42_RS10690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3B42_RS10695	COG0107	imidazoleglycerol-phosphate synthase activity
C3B42_RS10710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3B42_RS10715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3B42_RS10720	COG0724	RNA recognition motif
C3B42_RS10725	COG0745	RESPONSE REGULATOR receiver
C3B42_RS10730	COG0642	Histidine kinase
C3B42_RS10750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3B42_RS10755	COG2353	YceI-like domain
C3B42_RS10760	COG0133	tryptophan synthase activity
C3B42_RS10775	COG1408	metallophosphoesterase
C3B42_RS10790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3B42_RS10795	COG4208	sulfate ABC transporter
C3B42_RS10800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C3B42_RS10825	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3B42_RS10830	COG1959	2 iron, 2 sulfur cluster binding
C3B42_RS10835	COG1217	gtp-binding protein TYPA
C3B42_RS10840	COG2391	methyltransferase activity
C3B42_RS10845	COG0425	Belongs to the sulfur carrier protein TusA family
C3B42_RS10860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3B42_RS10890	COG0745	RESPONSE REGULATOR receiver
C3B42_RS10895	COG0642	Histidine kinase
C3B42_RS10900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C3B42_RS10905	COG2860	membrane
C3B42_RS10920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3B42_RS10930	COG1459	type II secretion system
C3B42_RS10940	COG1073	alpha beta
C3B42_RS10945	COG1073	alpha beta
C3B42_RS10965	COG4974	Belongs to the 'phage' integrase family
C3B42_RS10990	COG3328	transposase activity
C3B42_RS10995	COG3328	transposase activity