locus-tag	class	description
C2860_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2860_RS00010	COG0592	DNA-directed DNA polymerase activity
C2860_RS00015	COG0187	DNA topoisomerase II activity
C2860_RS00020	COG0492	ferredoxin-NADP+ reductase activity
C2860_RS00030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2860_RS00060	COG0500	methyltransferase
C2860_RS00065	COG3842	ATPase activity
C2860_RS00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2860_RS00125	COG0840	transmembrane signaling receptor activity
C2860_RS00130	COG0840	transmembrane signaling receptor activity
C2860_RS00135	COG2081	HI0933 family
C2860_RS00160	COG1959	2 iron, 2 sulfur cluster binding
C2860_RS00180	COG0175	sulfate reduction
C2860_RS00185	COG2895	sulfate adenylyltransferase (ATP) activity
C2860_RS00195	COG2814	Major facilitator Superfamily
C2860_RS00200	COG0783	Belongs to the Dps family
C2860_RS00205	COG0546	phosphoglycolate phosphatase activity
C2860_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
C2860_RS00220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2860_RS00260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2860_RS00265	COG0233	cytoplasmic translational termination
C2860_RS00270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2860_RS00280	COG0352	thiamine-phosphate diphosphorylase activity
C2860_RS00285	COG0670	Belongs to the BI1 family
C2860_RS00325	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2860_RS00330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2860_RS00335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2860_RS00340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2860_RS00345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2860_RS00350	COG1077	Cell shape determining protein MreB Mrl
C2860_RS00365	COG0445	tRNA wobble uridine modification
C2860_RS00370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C2860_RS00375	COG3421	Type III restriction
C2860_RS00380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2860_RS00385	COG1028	Short-chain dehydrogenase reductase Sdr
C2860_RS00390	COG0659	secondary active sulfate transmembrane transporter activity
C2860_RS00405	COG1222	aaa ATPase
C2860_RS00415	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C2860_RS00420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2860_RS00430	COG3077	Addiction module antitoxin, RelB DinJ family
C2860_RS00455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2860_RS00460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2860_RS00475	COG1086	Polysaccharide biosynthesis protein
C2860_RS00480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2860_RS00495	COG1083	cytidylyl-transferase
C2860_RS00505	COG2089	acid synthase
C2860_RS00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2860_RS00570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2860_RS00575	COG0438	transferase activity, transferring glycosyl groups
C2860_RS00620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2860_RS00635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2860_RS00650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2860_RS00660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2860_RS00665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2860_RS00670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2860_RS00685	COG0101	tRNA pseudouridine synthase activity
C2860_RS00695	COG1420	regulation of RNA biosynthetic process
C2860_RS00700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2860_RS00705	COG0443	Heat shock 70 kDa protein
C2860_RS00725	COG2121	Domain of unknown function (DUF374)
C2860_RS00730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2860_RS00740	COG0195	Participates in both transcription termination and antitermination
C2860_RS00745	COG0215	cysteine-tRNA ligase activity
C2860_RS00755	COG1393	Belongs to the ArsC family
C2860_RS00760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2860_RS00765	COG0343	queuine tRNA-ribosyltransferase activity
C2860_RS00800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2860_RS00805	COG0557	exoribonuclease II activity
C2860_RS00815	COG1466	dna polymerase III delta subunit
C2860_RS00820	COG0360	Binds together with S18 to 16S ribosomal RNA
C2860_RS00825	COG0629	single-stranded DNA binding
C2860_RS00830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2860_RS00835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2860_RS00850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2860_RS00860	COG0157	Belongs to the NadC ModD family
C2860_RS00875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2860_RS00885	COG0083	homoserine kinase activity
C2860_RS00895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2860_RS00900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2860_RS00905	COG0779	Required for maturation of 30S ribosomal subunits
C2860_RS00910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2860_RS00910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2860_RS00915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2860_RS00920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2860_RS00925	COG1185	polyribonucleotide nucleotidyltransferase activity
C2860_RS00925	COG0539	negative regulation of cytoplasmic translation
C2860_RS00930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2860_RS00935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2860_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2860_RS00940	COG0072	phenylalanine-tRNA ligase activity
C2860_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2860_RS00945	COG0072	phenylalanine-tRNA ligase activity
C2860_RS00950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2860_RS00960	COG0825	malonyl-CoA metabolic process
C2860_RS00965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2860_RS00970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2860_RS00980	COG0602	queuosine metabolic process
C2860_RS00990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2860_RS01000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2860_RS01010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2860_RS01020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2860_RS01025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2860_RS01035	COG3328	transposase activity
C2860_RS01045	COG0356	it plays a direct role in the translocation of protons across the membrane
C2860_RS01050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2860_RS01055	COG0191	fructose-bisphosphate aldolase activity
C2860_RS01065	COG0745	RESPONSE REGULATOR receiver
C2860_RS01070	COG0642	Histidine kinase
C2860_RS01095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2860_RS01105	COG3287	FIST C domain
C2860_RS01105	COG2200	EAL domain
C2860_RS01105	COG2199	diguanylate cyclase activity
C2860_RS01125	COG3043	anaerobic respiration
C2860_RS01130	COG0348	domain, Protein
C2860_RS01135	COG0437	4 iron, 4 sulfur cluster binding
C2860_RS01140	COG0243	molybdopterin cofactor binding
C2860_RS01155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2860_RS01160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2860_RS01165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2860_RS01175	COG2404	hydrolase activity, acting on ester bonds
C2860_RS01205	COG2030	dehydratase
C2860_RS01230	COG1401	restriction endodeoxyribonuclease activity
C2860_RS01240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2860_RS01245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2860_RS01250	COG0542	response to heat
C2860_RS01305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2860_RS01315	COG1459	type II secretion system
C2860_RS01320	COG0598	Magnesium transport protein CorA
C2860_RS01370	COG1160	GTP binding
C2860_RS01410	COG4115	mRNA cleavage
C2860_RS01430	COG1178	ABC-type Fe3 transport system permease component
C2860_RS01435	COG1840	ABC-type Fe3 transport system, periplasmic component
C2860_RS01480	COG0148	phosphopyruvate hydratase activity
C2860_RS01495	COG2814	Major facilitator Superfamily
C2860_RS01505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2860_RS01510	COG0049	tRNA binding
C2860_RS01515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2860_RS01520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2860_RS01525	COG0497	DNA recombination
C2860_RS01530	COG0497	DNA recombination
C2860_RS01535	COG0840	transmembrane signaling receptor activity
C2860_RS01540	COG0826	peptidase U32
C2860_RS01550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2860_RS01560	COG0752	glycyl-tRNA synthetase alpha subunit
C2860_RS01565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2860_RS01575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2860_RS01575	COG1519	Transferase
C2860_RS01580	COG0564	pseudouridine synthase activity
C2860_RS01585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2860_RS01590	COG0228	four-way junction DNA binding
C2860_RS01595	COG1837	Belongs to the UPF0109 family
C2860_RS01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2860_RS01625	COG0745	RESPONSE REGULATOR receiver
C2860_RS01635	COG4786	Flagellar basal body rod
C2860_RS01640	COG1815	bacterial-type flagellum-dependent cell motility
C2860_RS01645	COG1766	The M ring may be actively involved in energy transduction
C2860_RS01650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2860_RS01660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2860_RS01670	COG1749	Flagellar hook protein flgE
C2860_RS01675	COG1749	Flagellar hook protein flgE
C2860_RS01700	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2860_RS01715	COG1419	protein localization to endoplasmic reticulum
C2860_RS01720	COG0455	bacterial-type flagellum organization
C2860_RS01755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2860_RS01765	COG1157	protein secretion by the type III secretion system
C2860_RS01770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2860_RS01775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2860_RS01785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2860_RS01805	COG3328	transposase activity
C2860_RS01810	COG1686	Belongs to the peptidase S11 family
C2860_RS01825	COG0840	transmembrane signaling receptor activity
C2860_RS01835	COG0745	RESPONSE REGULATOR receiver
C2860_RS01840	COG1639	'signal transduction protein
C2860_RS01845	COG0840	transmembrane signaling receptor activity
C2860_RS01850	COG2199	diguanylate cyclase activity
C2860_RS01860	COG5001	Diguanylate cyclase
C2860_RS01860	COG3300	MHYT domain
C2860_RS01865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2860_RS01875	COG0336	Belongs to the RNA methyltransferase TrmD family
C2860_RS01880	COG0335	large ribosomal subunit rRNA binding
C2860_RS01885	COG0586	Pfam SNARE associated Golgi protein
C2860_RS01895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2860_RS01910	COG0251	oxidation-reduction process
C2860_RS01915	COG3610	response to peptide
C2860_RS01920	COG2966	Psort location CytoplasmicMembrane, score
C2860_RS01935	COG0811	peptide transport
C2860_RS01960	COG1971	Probably functions as a manganese efflux pump
C2860_RS01975	COG0628	permease
C2860_RS01985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2860_RS01990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2860_RS01995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2860_RS02025	COG4773	Receptor
C2860_RS02030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2860_RS02045	COG0142	geranyltranstransferase activity
C2860_RS02050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2860_RS02055	COG0442	prolyl-tRNA aminoacylation
C2860_RS02060	COG0668	transmembrane transport
C2860_RS02065	COG0617	tRNA 3'-terminal CCA addition
C2860_RS02070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2860_RS02075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2860_RS02080	COG1862	Preprotein translocase
C2860_RS02085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2860_RS02090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2860_RS02105	COG1360	Flagellar Motor Protein
C2860_RS02110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2860_RS02120	COG0495	leucyl-tRNA aminoacylation
C2860_RS02130	COG0285	dihydrofolate synthase activity
C2860_RS02155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2860_RS02160	COG0077	Prephenate dehydratase
C2860_RS02160	COG1605	Chorismate mutase
C2860_RS02165	COG0454	-acetyltransferase
C2860_RS02175	COG1396	sequence-specific DNA binding
C2860_RS02200	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2860_RS02205	COG0444	Belongs to the ABC transporter superfamily
C2860_RS02210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2860_RS02215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2860_RS02225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2860_RS02250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2860_RS02255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2860_RS02270	COG0250	Participates in transcription elongation, termination and antitermination
C2860_RS02275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2860_RS02280	COG0081	regulation of translation
C2860_RS02285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2860_RS02290	COG0222	ribosome binding
C2860_RS02295	COG0085	RNA polymerase activity
C2860_RS02300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2860_RS02320	COG0386	Belongs to the glutathione peroxidase family
C2860_RS02325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2860_RS02330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2860_RS02355	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2860_RS02370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2860_RS02390	COG0298	carbon dioxide binding
C2860_RS02395	COG0409	Hydrogenase expression formation protein
C2860_RS02400	COG4804	nuclease activity
C2860_RS02410	COG0309	Hydrogenase expression formation protein (HypE)
C2860_RS02425	COG0310	cobalt ion transport
C2860_RS02445	COG0745	RESPONSE REGULATOR receiver
C2860_RS02495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2860_RS02505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2860_RS02515	COG1295	ribonuclease BN
C2860_RS02520	COG0277	FAD linked oxidase domain protein
C2860_RS02530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2860_RS02535	COG2226	methyltransferase
C2860_RS02540	COG0196	riboflavin kinase activity
C2860_RS02555	COG1739	Uncharacterized protein family UPF0029
C2860_RS02580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2860_RS02610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2860_RS02655	COG1216	Glycosyl transferase, family 2
C2860_RS02660	COG0438	transferase activity, transferring glycosyl groups
C2860_RS02680	COG0859	PFAM glycosyl transferase family 9
C2860_RS02700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2860_RS02705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2860_RS02705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2860_RS02715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2860_RS02725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2860_RS02735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2860_RS02750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2860_RS02760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2860_RS02815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2860_RS02820	COG1278	Cold shock
C2860_RS02835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2860_RS02850	COG1522	sequence-specific DNA binding
C2860_RS02855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2860_RS02855	COG1648	precorrin-2 dehydrogenase activity
C2860_RS02890	COG3328	transposase activity
C2860_RS02895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2860_RS02895	COG1648	precorrin-2 dehydrogenase activity
C2860_RS02915	COG0535	radical SAM domain protein
C2860_RS02925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2860_RS02940	COG2010	Cytochrome c
C2860_RS02950	COG3256	nitric oxide reductase
C2860_RS02975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2860_RS03015	COG1337	RAMP superfamily
C2860_RS03045	COG3344	reverse transcriptase
C2860_RS03055	COG1518	maintenance of DNA repeat elements
C2860_RS03120	COG4680	protein conserved in bacteria
C2860_RS03125	COG0582	viral genome integration into host DNA
C2860_RS03150	COG2326	polyphosphate kinase activity
C2860_RS03155	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2860_RS03160	COG0740	serine-type endopeptidase activity
C2860_RS03165	COG0242	peptide deformylase activity
C2860_RS03175	COG0840	transmembrane signaling receptor activity
C2860_RS03180	COG0840	transmembrane signaling receptor activity
C2860_RS03205	COG0301	tRNA thio-modification
C2860_RS03205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2860_RS03210	COG0708	Exodeoxyribonuclease III
C2860_RS03230	COG0051	transcription antitermination factor activity, RNA binding
C2860_RS03235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2860_RS03240	COG0088	Forms part of the polypeptide exit tunnel
C2860_RS03245	COG0089	rRNA binding
C2860_RS03250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2860_RS03255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2860_RS03260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2860_RS03265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2860_RS03270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2860_RS03275	COG0255	Belongs to the universal ribosomal protein uL29 family
C2860_RS03280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2860_RS03285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2860_RS03290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2860_RS03295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2860_RS03300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2860_RS03305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2860_RS03310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2860_RS03315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2860_RS03320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2860_RS03325	COG0200	Binds to the 23S rRNA
C2860_RS03330	COG0201	protein transport
C2860_RS03335	COG0024	Methionine aminopeptidase
C2860_RS03340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2860_RS03345	COG1573	uracil-dna glycosylase
C2860_RS03355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2860_RS03365	COG1032	radical SAM domain protein
C2860_RS03375	COG0583	DNA-binding transcription factor activity
C2860_RS03380	COG2855	membrane
C2860_RS03395	COG3852	Histidine kinase
C2860_RS03400	COG0840	transmembrane signaling receptor activity
C2860_RS03405	COG0840	transmembrane signaling receptor activity
C2860_RS03425	COG0450	alkyl hydroperoxide reductase
C2860_RS03430	COG3118	belongs to the thioredoxin family
C2860_RS03445	COG3328	transposase activity
C2860_RS03455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2860_RS03480	COG0012	GTP binding
C2860_RS03485	COG1639	'signal transduction protein
C2860_RS03515	COG0730	response to heat
C2860_RS03520	COG1045	serine acetyltransferase
C2860_RS03525	COG1166	arginine decarboxylase activity
C2860_RS03530	COG0124	histidyl-tRNA synthetase
C2860_RS03535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2860_RS03540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2860_RS03545	COG0163	prenyltransferase activity
C2860_RS03555	COG0359	binds to the 23S rRNA
C2860_RS03560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2860_RS03565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2860_RS03575	COG0084	hydrolase, TatD family'
C2860_RS03590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2860_RS03595	COG0131	Imidazoleglycerol-phosphate dehydratase
C2860_RS03600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2860_RS03615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2860_RS03620	COG0456	acetyltransferase
C2860_RS03630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2860_RS03640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2860_RS03645	COG0328	RNA-DNA hybrid ribonuclease activity
C2860_RS03650	COG0840	transmembrane signaling receptor activity
C2860_RS03660	COG1401	restriction endodeoxyribonuclease activity
C2860_RS03690	COG0513	Belongs to the DEAD box helicase family
C2860_RS03695	COG2217	Heavy metal translocating P-type atpase
C2860_RS03705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2860_RS03710	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2860_RS03715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2860_RS03720	COG0095	Lipoate-protein ligase
C2860_RS03725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2860_RS03765	COG0488	(ABC) transporter
C2860_RS03770	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2860_RS03790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2860_RS03800	COG0849	cell division
C2860_RS03805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2860_RS03810	COG2391	methyltransferase activity
C2860_RS03820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2860_RS03830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2860_RS03865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2860_RS03885	COG2089	acid synthase
C2860_RS03905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2860_RS03910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2860_RS03910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2860_RS03915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2860_RS03925	COG1083	cytidylyl-transferase
C2860_RS03930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2860_RS03940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2860_RS03950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2860_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
C2860_RS04015	COG0546	phosphoglycolate phosphatase activity
C2860_RS04035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2860_RS04040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2860_RS04060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2860_RS04065	COG1215	transferase activity, transferring glycosyl groups
C2860_RS04080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2860_RS04110	COG0166	Belongs to the GPI family
C2860_RS04150	COG0113	porphobilinogen synthase activity
C2860_RS04160	COG0357	Ribosomal RNA small subunit methyltransferase G
C2860_RS04190	COG1484	DNA-dependent DNA replication
C2860_RS04295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2860_RS04310	COG0745	RESPONSE REGULATOR receiver
C2860_RS04315	COG0642	Histidine kinase
C2860_RS04320	COG3111	PFAM Bacterial OB fold (BOF) protein
C2860_RS04335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2860_RS04350	COG5000	phosphorelay sensor kinase activity
C2860_RS04380	COG3328	transposase activity
C2860_RS04395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2860_RS04400	COG0066	3-isopropylmalate dehydratase activity
C2860_RS04405	COG0473	3-isopropylmalate dehydrogenase activity
C2860_RS04420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2860_RS04425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2860_RS04430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2860_RS04435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2860_RS04440	COG0202	RNA polymerase activity
C2860_RS04445	COG0203	ribosomal protein L17
C2860_RS04450	COG0154	amidase activity
C2860_RS04455	COG0516	GMP reductase activity
C2860_RS04455	COG0517	IMP dehydrogenase activity
C2860_RS04470	COG0840	transmembrane signaling receptor activity
C2860_RS04475	COG0754	glutathionylspermidine amidase activity
C2860_RS04485	COG0513	Belongs to the DEAD box helicase family
C2860_RS04515	COG0457	Tetratricopeptide repeat
C2860_RS04515	COG0859	PFAM glycosyl transferase family 9
C2860_RS04525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2860_RS04580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2860_RS04585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2860_RS04590	COG1496	oxidoreductase activity
C2860_RS04595	COG0788	formyltetrahydrofolate deformylase activity
C2860_RS04600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2860_RS04605	COG1114	Component of the transport system for branched-chain amino acids
C2860_RS04630	COG0745	RESPONSE REGULATOR receiver
C2860_RS04635	COG5002	protein histidine kinase activity
C2860_RS04640	COG3328	transposase activity
C2860_RS04695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2860_RS04710	COG1696	Membrane protein involved in D-alanine export
C2860_RS04715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2860_RS04740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2860_RS04755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2860_RS04760	COG0351	phosphomethylpyrimidine kinase
C2860_RS04760	COG0352	thiamine-phosphate diphosphorylase activity
C2860_RS04760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2860_RS04765	COG0351	phosphomethylpyrimidine kinase
C2860_RS04790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2860_RS04795	COG1611	Belongs to the LOG family
C2860_RS04820	COG0217	transcriptional regulatory protein
C2860_RS04825	COG1132	(ABC) transporter
C2860_RS04835	COG0745	RESPONSE REGULATOR receiver
C2860_RS04840	COG0642	Histidine kinase
C2860_RS04850	COG0840	transmembrane signaling receptor activity
C2860_RS04855	COG0840	transmembrane signaling receptor activity
C2860_RS04860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2860_RS04865	COG0750	zinc metalloprotease
C2860_RS04870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2860_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
C2860_RS04880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2860_RS04885	COG0612	Peptidase, M16
C2860_RS04890	COG0167	dihydroorotate dehydrogenase activity
C2860_RS04895	COG1132	(ABC) transporter
C2860_RS04900	COG0728	peptidoglycan biosynthetic process
C2860_RS04910	COG0735	belongs to the Fur family
C2860_RS04915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2860_RS04925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2860_RS04930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2860_RS04930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2860_RS04960	COG3275	phosphorelay sensor kinase activity
C2860_RS04965	COG3279	Response regulator of the LytR AlgR family
C2860_RS04970	COG2200	EAL domain
C2860_RS04980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2860_RS04995	COG3046	protein related to deoxyribodipyrimidine photolyase
C2860_RS05005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2860_RS05010	COG3040	lipid binding
C2860_RS05020	COG1090	epimerase
C2860_RS05025	COG0415	Belongs to the DNA photolyase family
C2860_RS05035	COG3177	Filamentation induced by cAMP protein fic
C2860_RS05065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2860_RS05070	COG0732	type I restriction modification DNA specificity domain
C2860_RS05075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2860_RS05080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2860_RS05085	COG2199	diguanylate cyclase activity
C2860_RS05085	COG2200	EAL domain
C2860_RS05085	COG3287	FIST C domain
C2860_RS05090	COG3706	GGDEF domain
C2860_RS05105	COG0596	Alpha beta hydrolase
C2860_RS05140	COG0519	Catalyzes the synthesis of GMP from XMP
C2860_RS05140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2860_RS05145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2860_RS05155	COG1451	nucleotide metabolic process
C2860_RS05215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2860_RS05215	COG0475	glutathione-regulated potassium exporter activity
C2860_RS05230	COG4191	Histidine kinase
C2860_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2860_RS05240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2860_RS05260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2860_RS05270	COG0546	phosphoglycolate phosphatase activity
C2860_RS05290	COG4206	TonB-dependent receptor
C2860_RS05295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2860_RS05325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2860_RS05340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2860_RS05355	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2860_RS05365	COG0653	protein targeting
C2860_RS05370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2860_RS05390	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2860_RS05400	COG1333	cytochrome c biogenesis protein
C2860_RS05400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2860_RS05405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2860_RS05405	COG1333	cytochrome c biogenesis protein
C2860_RS05420	COG0500	methyltransferase
C2860_RS05425	COG4251	negative regulation of phosphorylation
C2860_RS05425	COG5001	Diguanylate cyclase
C2860_RS05425	COG3706	GGDEF domain
C2860_RS05425	COG2203	Gaf domain
C2860_RS05460	COG0484	heat shock protein binding
C2860_RS05470	COG2201	protein-glutamate methylesterase activity
C2860_RS05475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2860_RS05490	COG2198	Histidine kinase
C2860_RS05490	COG0643	Histidine kinase
C2860_RS05495	COG0745	RESPONSE REGULATOR receiver
C2860_RS05520	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2860_RS05540	COG0659	secondary active sulfate transmembrane transporter activity
C2860_RS05545	COG0659	secondary active sulfate transmembrane transporter activity
C2860_RS05550	COG1160	GTP binding
C2860_RS05555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2860_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
C2860_RS05575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2860_RS05580	COG0440	acetolactate synthase activity
C2860_RS05585	COG0028	Belongs to the TPP enzyme family
C2860_RS05625	COG0037	tRNA processing
C2860_RS05635	COG0303	'Molybdopterin
C2860_RS05645	COG2321	neutral zinc metallopeptidase
C2860_RS05665	COG0501	Belongs to the peptidase M48B family
C2860_RS05670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2860_RS05690	COG0339	signal peptide processing
C2860_RS05700	COG2890	protein-(glutamine-N5) methyltransferase activity
C2860_RS05705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2860_RS05710	COG0494	nUDIX hydrolase
C2860_RS05715	COG0527	aspartate kinase activity
C2860_RS05730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2860_RS05750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2860_RS05750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2860_RS05755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2860_RS05760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2860_RS05770	COG3135	benzoate transporter
C2860_RS05780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2860_RS05785	COG2258	MOSC domain
C2860_RS05795	COG1119	ATPase activity
C2860_RS05820	COG1193	negative regulation of DNA recombination
C2860_RS05835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2860_RS05845	COG0039	L-malate dehydrogenase activity
C2860_RS05870	COG0275	rRNA processing
C2860_RS05880	COG0776	regulation of translation
C2860_RS05900	COG2201	protein-glutamate methylesterase activity
C2860_RS05920	COG0484	heat shock protein binding
C2860_RS05925	COG0789	Transcriptional regulator
C2860_RS05930	COG0861	Integral membrane protein TerC family
C2860_RS05935	COG1663	tetraacyldisaccharide 4'-kinase activity
C2860_RS05940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2860_RS05945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2860_RS05970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2860_RS05975	COG0805	protein transport
C2860_RS05980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2860_RS05985	COG0667	Aldo Keto reductase
C2860_RS06005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2860_RS06010	COG0488	(ABC) transporter
C2860_RS06015	COG1610	YqeY-like protein
C2860_RS06020	COG0739	heme binding
C2860_RS06035	COG3706	GGDEF domain
C2860_RS06040	COG3328	transposase activity
C2860_RS06045	COG1942	4-Oxalocrotonate Tautomerase
C2860_RS06050	COG0583	DNA-binding transcription factor activity
C2860_RS06065	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2860_RS06070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2860_RS06080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2860_RS06080	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2860_RS06085	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2860_RS06095	COG2176	DNA-directed DNA polymerase activity
C2860_RS06100	COG0135	phosphoribosylanthranilate isomerase activity
C2860_RS06105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2860_RS06135	COG0287	Prephenate dehydrogenase
C2860_RS06140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2860_RS06145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C2860_RS06155	COG0612	Peptidase, M16
C2860_RS06185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2860_RS06210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2860_RS06245	COG1666	GTP binding
C2860_RS06250	COG2363	Small membrane protein
C2860_RS06255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2860_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
C2860_RS06270	COG0277	FAD linked oxidase domain protein
C2860_RS06300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2860_RS06310	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2860_RS06320	COG3258	Cytochrome c
C2860_RS06340	COG0642	Histidine kinase
C2860_RS06345	COG2076	Multidrug Resistance protein
C2860_RS06400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2860_RS06415	COG2201	protein-glutamate methylesterase activity
C2860_RS06425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2860_RS06445	COG1686	Belongs to the peptidase S11 family
C2860_RS06450	COG1137	ATPase activity
C2860_RS06455	COG0802	atpase or kinase
C2860_RS06460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2860_RS06470	COG0300	oxidoreductase activity
C2860_RS06535	COG4974	Belongs to the 'phage' integrase family
C2860_RS06550	COG0484	heat shock protein binding
C2860_RS06555	COG0484	heat shock protein binding
C2860_RS06565	COG0840	transmembrane signaling receptor activity
C2860_RS06575	COG0840	transmembrane signaling receptor activity
C2860_RS06580	COG1607	acyl-coa hydrolase
C2860_RS06585	COG0488	(ABC) transporter
C2860_RS06595	COG0778	Nitroreductase
C2860_RS06600	COG1902	pentaerythritol trinitrate reductase activity
C2860_RS06605	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2860_RS06610	COG1733	regulation of RNA biosynthetic process
C2860_RS06630	COG0552	protein localization to endoplasmic reticulum
C2860_RS06645	COG1418	mRNA catabolic process
C2860_RS06650	COG0742	ribosomal rna small subunit methyltransferase
C2860_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2860_RS06680	COG3328	transposase activity
C2860_RS06685	COG0137	argininosuccinate synthase activity
C2860_RS06700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2860_RS06710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2860_RS06715	COG0159	tryptophan synthase activity
C2860_RS06720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2860_RS06725	COG2255	four-way junction helicase activity
C2860_RS06730	COG0628	permease
C2860_RS06775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2860_RS06780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2860_RS06780	COG2169	Transcriptional regulator
C2860_RS06785	COG1944	ATP diphosphatase activity
C2860_RS06790	COG1944	ATP diphosphatase activity
C2860_RS06795	COG2171	N-acyltransferase activity
C2860_RS06800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2860_RS06825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2860_RS06830	COG2081	HI0933 family
C2860_RS06835	COG0726	polysaccharide deacetylase
C2860_RS06840	COG2354	Protein conserved in bacteria
C2860_RS06850	COG2814	Major facilitator Superfamily
C2860_RS06870	COG4662	Binding-protein-dependent transport system inner membrane component
C2860_RS06875	COG2998	abc-type tungstate transport system, permease component
C2860_RS06880	COG0303	'Molybdopterin
C2860_RS06900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2860_RS06910	COG0437	4 iron, 4 sulfur cluster binding
C2860_RS06950	COG2204	response regulator
C2860_RS06970	COG1305	Transglutaminase-like
C2860_RS06975	COG0709	Synthesizes selenophosphate from selenide and ATP
C2860_RS06980	COG0210	DNA helicase
C2860_RS06985	COG0475	glutathione-regulated potassium exporter activity
C2860_RS06985	COG0569	domain protein
C2860_RS06990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2860_RS07070	COG3123	guanosine phosphorylase activity
C2860_RS07075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2860_RS07085	COG0772	Belongs to the SEDS family
C2860_RS07095	COG0564	pseudouridine synthase activity
C2860_RS07105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2860_RS07110	COG2884	Cell division ATP-binding protein ftsE
C2860_RS07130	COG0768	penicillin binding
C2860_RS07135	COG1338	Plays a role in the flagellum-specific transport system
C2860_RS07140	COG0784	Response regulator, receiver
C2860_RS07140	COG3437	response regulator, receiver
C2860_RS07150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2860_RS07185	COG0745	RESPONSE REGULATOR receiver
C2860_RS07210	COG0322	excinuclease ABC activity
C2860_RS07215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2860_RS07220	COG1979	alcohol dehydrogenase
C2860_RS07240	COG2207	Transcriptional regulator
C2860_RS07245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2860_RS07260	COG3328	transposase activity
C2860_RS07315	COG0563	adenylate kinase activity
C2860_RS07320	COG0563	adenylate kinase activity
C2860_RS07325	COG1966	Carbon starvation protein
C2860_RS07350	COG4771	TonB-dependent receptor
C2860_RS07355	COG0673	inositol 2-dehydrogenase activity
C2860_RS07365	COG2165	general secretion pathway protein
C2860_RS07370	COG0305	Participates in initiation and elongation during chromosome replication
C2860_RS07375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2860_RS07390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2860_RS07410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2860_RS07415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2860_RS07430	COG3706	GGDEF domain
C2860_RS07450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2860_RS07460	COG0706	membrane insertase activity
C2860_RS07465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2860_RS07475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2860_RS07480	COG0542	response to heat
C2860_RS07485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2860_RS07490	COG0577	efflux transmembrane transporter activity
C2860_RS07490	COG1136	(ABC) transporter
C2860_RS07495	COG0577	efflux transmembrane transporter activity
C2860_RS07495	COG1136	(ABC) transporter
C2860_RS07515	COG0811	peptide transport
C2860_RS07520	COG0848	biopolymer transport protein
C2860_RS07530	COG3706	GGDEF domain
C2860_RS07545	COG1686	Belongs to the peptidase S11 family
C2860_RS07550	COG0459	protein refolding
C2860_RS07555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2860_RS07565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2860_RS07570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2860_RS07580	COG0835	chemotaxis
C2860_RS07590	COG1570	exodeoxyribonuclease VII activity
C2860_RS07610	COG1692	metallophosphoesterase
C2860_RS07630	COG3920	Histidine kinase
C2860_RS07645	COG0840	transmembrane signaling receptor activity
C2860_RS07650	COG2081	HI0933 family
C2860_RS07655	COG0642	Histidine kinase
C2860_RS07660	COG0745	RESPONSE REGULATOR receiver
C2860_RS07675	COG4251	negative regulation of phosphorylation
C2860_RS07675	COG3706	GGDEF domain
C2860_RS07675	COG5001	Diguanylate cyclase
C2860_RS07675	COG2203	Gaf domain
C2860_RS07685	COG2204	response regulator
C2860_RS07705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2860_RS07720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2860_RS07725	COG1116	anion transmembrane transporter activity
C2860_RS07740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2860_RS07775	COG1858	cytochrome C peroxidase
C2860_RS07780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2860_RS07785	COG0768	penicillin binding
C2860_RS07790	COG0772	Belongs to the SEDS family
C2860_RS07800	COG1373	ATPase (AAA superfamily
C2860_RS07815	COG1968	undecaprenyl-diphosphatase activity
C2860_RS07830	COG0314	molybdopterin synthase activity
C2860_RS07840	COG0174	glutamine synthetase
C2860_RS07845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2860_RS07850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2860_RS07855	COG0284	orotidine-5'-phosphate decarboxylase activity
C2860_RS07880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2860_RS07890	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2860_RS07895	COG0632	four-way junction helicase activity
C2860_RS07900	COG0840	transmembrane signaling receptor activity
C2860_RS07910	COG0585	pseudouridine synthase activity
C2860_RS07915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2860_RS07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2860_RS07935	COG0835	chemotaxis
C2860_RS07935	COG0784	Response regulator, receiver
C2860_RS07940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2860_RS07945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2860_RS07960	COG0556	nucleotide-excision repair
C2860_RS07965	COG0165	Argininosuccinate lyase
C2860_RS07970	COG3706	GGDEF domain
C2860_RS07985	COG0719	Fe-S assembly protein
C2860_RS07990	COG0396	ATPase activity
C2860_RS08000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2860_RS08005	COG2166	iron-sulfur cluster assembly
C2860_RS08015	COG0439	Biotin carboxylase
C2860_RS08035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2860_RS08045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2860_RS08050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2860_RS08085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2860_RS08105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2860_RS08110	COG2814	Major facilitator Superfamily
C2860_RS08130	COG0525	valine-tRNA ligase activity
C2860_RS08165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2860_RS08185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2860_RS08195	COG5002	protein histidine kinase activity
C2860_RS08210	COG1408	metallophosphoesterase
C2860_RS08220	COG2353	YceI-like domain
C2860_RS08235	COG1136	(ABC) transporter
C2860_RS08260	COG2217	Heavy metal translocating P-type atpase
C2860_RS08265	COG2199	diguanylate cyclase activity
C2860_RS08265	COG2200	EAL domain
C2860_RS08265	COG3287	FIST C domain
C2860_RS08270	COG0194	GDP metabolic process
C2860_RS08280	COG1136	(ABC) transporter
C2860_RS08285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2860_RS08290	COG0052	Belongs to the universal ribosomal protein uS2 family
C2860_RS08295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2860_RS08310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2860_RS08315	COG0579	oxidoreductase
C2860_RS08320	COG1058	Belongs to the CinA family
C2860_RS08320	COG1546	Belongs to the CinA family
C2860_RS08380	COG0745	RESPONSE REGULATOR receiver
C2860_RS08390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2860_RS08405	COG2176	DNA-directed DNA polymerase activity
C2860_RS08450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2860_RS08455	COG0280	phosphate acetyltransferase
C2860_RS08465	COG0616	signal peptide processing
C2860_RS08470	COG0402	S-adenosylhomocysteine deaminase activity
C2860_RS08475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2860_RS08490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2860_RS08495	COG0482	sulfurtransferase activity
C2860_RS08500	COG0482	sulfurtransferase activity
C2860_RS08510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2860_RS08520	COG0481	GTPase activity
C2860_RS08525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2860_RS08535	COG2207	Transcriptional regulator
C2860_RS08540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2860_RS08545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2860_RS08550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2860_RS08565	COG2095	MarC family integral membrane protein
C2860_RS08570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2860_RS08585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2860_RS08630	COG2885	chlorophyll binding
C2860_RS08635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2860_RS08640	COG2264	protein methyltransferase activity
C2860_RS08645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2860_RS08655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2860_RS08665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2860_RS08670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2860_RS08675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2860_RS08690	COG0840	transmembrane signaling receptor activity
C2860_RS08750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2860_RS08760	COG0133	tryptophan synthase activity
C2860_RS08765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2860_RS08770	COG1793	dna ligase
C2860_RS08780	COG0626	cystathionine gamma-synthase activity
C2860_RS08810	COG0745	RESPONSE REGULATOR receiver
C2860_RS08850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2860_RS08890	COG0528	UMP kinase activity
C2860_RS08895	COG1758	RNA polymerase activity
C2860_RS08900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2860_RS08920	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2860_RS08935	COG0193	aminoacyl-tRNA hydrolase activity
C2860_RS08940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2860_RS08945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2860_RS08950	COG0681	Belongs to the peptidase S26 family
C2860_RS08955	COG0698	ribose 5-phosphate isomerase
C2860_RS09005	COG2199	diguanylate cyclase activity
C2860_RS09005	COG3287	FIST C domain
C2860_RS09005	COG2200	EAL domain
C2860_RS09015	COG0259	pyridoxamine-phosphate oxidase activity
C2860_RS09020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2860_RS09040	COG0513	Belongs to the DEAD box helicase family
C2860_RS09060	COG0326	Molecular chaperone. Has ATPase activity
C2860_RS09065	COG5001	Diguanylate cyclase
C2860_RS09065	COG2203	Gaf domain
C2860_RS09065	COG3706	GGDEF domain
C2860_RS09065	COG4251	negative regulation of phosphorylation
C2860_RS09070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2860_RS09070	COG2205	protein histidine kinase activity
C2860_RS09095	COG0010	Belongs to the arginase family
C2860_RS09110	COG0581	inorganic phosphate transmembrane transporter activity
C2860_RS09115	COG0573	inorganic phosphate transmembrane transporter activity
C2860_RS09120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2860_RS09135	COG4335	DNA alkylation repair
C2860_RS09140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2860_RS09150	COG2264	protein methyltransferase activity
C2860_RS09175	COG2995	paraquat-inducible protein a
C2860_RS09185	COG3008	intermembrane lipid transfer
C2860_RS09190	COG0753	catalase activity
C2860_RS09205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2860_RS09210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2860_RS09225	COG0668	transmembrane transport
C2860_RS09230	COG1227	inorganic diphosphatase activity
C2860_RS09235	COG3012	SEC-C Motif Domain Protein
C2860_RS09245	COG1027	Aspartate ammonia-lyase
C2860_RS09250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2860_RS09255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2860_RS09260	COG1047	Peptidyl-prolyl cis-trans
C2860_RS09280	COG0823	Involved in the tonB-independent uptake of proteins
C2860_RS09290	COG0848	biopolymer transport protein
C2860_RS09295	COG0811	peptide transport
C2860_RS09300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2860_RS09305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2860_RS09310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2860_RS09315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2860_RS09320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2860_RS09325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2860_RS09335	COG1475	DNA binding
C2860_RS09340	COG1192	Involved in chromosome partitioning
C2860_RS09355	COG0840	transmembrane signaling receptor activity
C2860_RS09360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2860_RS09365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2860_RS09370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2860_RS09375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2860_RS09380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2860_RS09385	COG0358	DNA primase activity
C2860_RS09400	COG0571	ribonuclease III activity
C2860_RS09405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2860_RS09415	COG2326	polyphosphate kinase activity
C2860_RS09430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2860_RS09450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2860_RS09460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2860_RS09475	COG1196	nuclear chromosome segregation
C2860_RS09475	COG0741	lytic transglycosylase activity
C2860_RS09475	COG0739	heme binding
C2860_RS09495	COG2183	response to ionizing radiation
C2860_RS09500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2860_RS09505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2860_RS09510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2860_RS09515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2860_RS09515	COG0649	NAD binding
C2860_RS09520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2860_RS09530	COG0372	Belongs to the citrate synthase family
C2860_RS09540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2860_RS09545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2860_RS09550	COG0839	Belongs to the complex I subunit 6 family
C2860_RS09555	COG0713	ATP synthesis coupled electron transport
C2860_RS09560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2860_RS09570	COG1007	ATP synthesis coupled electron transport
C2860_RS09580	COG1053	succinate dehydrogenase
C2860_RS09585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2860_RS09605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2860_RS09610	COG0416	fatty acid biosynthetic process
C2860_RS09615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2860_RS09625	COG0105	UTP biosynthetic process
C2860_RS09635	COG0450	alkyl hydroperoxide reductase
C2860_RS09640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2860_RS09645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2860_RS09650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2860_RS09655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2860_RS09665	COG0181	hydroxymethylbilane synthase activity
C2860_RS09670	COG3328	transposase activity
C2860_RS09710	COG1335	isochorismatase
C2860_RS09750	COG3278	Belongs to the heme-copper respiratory oxidase family
C2860_RS09755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2860_RS09760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2860_RS09765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2860_RS09780	COG1242	4 iron, 4 sulfur cluster binding
C2860_RS09785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2860_RS09790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2860_RS09795	COG0492	ferredoxin-NADP+ reductase activity
C2860_RS09800	COG3118	belongs to the thioredoxin family
C2860_RS09805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2860_RS09830	COG0642	Histidine kinase
C2860_RS09835	COG0745	RESPONSE REGULATOR receiver
C2860_RS09845	COG0129	dihydroxy-acid dehydratase activity
C2860_RS09875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2860_RS09895	COG0585	pseudouridine synthase activity
C2860_RS09910	COG0793	Belongs to the peptidase S41A family
C2860_RS09915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2860_RS09920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2860_RS09925	COG0047	phosphoribosylformylglycinamidine synthase activity
C2860_RS09935	COG0204	Acyl-transferase
C2860_RS09940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2860_RS09945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2860_RS09950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2860_RS09955	COG0018	arginyl-trna synthetase
C2860_RS09965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2860_RS09970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2860_RS09975	COG0126	phosphoglycerate kinase activity
C2860_RS09980	COG0149	triose-phosphate isomerase activity
C2860_RS09985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2860_RS09990	COG0019	diaminopimelate decarboxylase activity
C2860_RS09995	COG1605	Chorismate mutase
C2860_RS09995	COG0077	Prephenate dehydratase
C2860_RS10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2860_RS10005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2860_RS10020	COG0424	maF-like protein
C2860_RS10030	COG0791	NLP P60 protein
C2860_RS10060	COG0189	ligase activity
C2860_RS10075	COG2200	EAL domain
C2860_RS10075	COG3287	FIST C domain
C2860_RS10075	COG2199	diguanylate cyclase activity
C2860_RS10080	COG0688	phosphatidylethanolamine metabolic process
C2860_RS10090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C2860_RS10100	COG0288	reversible hydration of carbon dioxide
C2860_RS10105	COG0156	8-amino-7-oxononanoate synthase activity
C2860_RS10110	COG0792	nuclease activity
C2860_RS10125	COG5002	protein histidine kinase activity
C2860_RS10130	COG0745	RESPONSE REGULATOR receiver
C2860_RS10185	COG1987	bacterial-type flagellum assembly
C2860_RS10200	COG1706	bacterial-type flagellum-dependent cell motility
C2860_RS10210	COG0418	dihydroorotase activity
C2860_RS10215	COG0347	Belongs to the P(II) protein family
C2860_RS10220	COG0004	ammonium transporteR
C2860_RS10225	COG0666	response to abiotic stimulus
C2860_RS10230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2860_RS10290	COG1742	UPF0060 membrane protein
C2860_RS10305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2860_RS10315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2860_RS10325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2860_RS10325	COG2205	protein histidine kinase activity
C2860_RS10325	COG2198	Histidine kinase
C2860_RS10325	COG0784	Response regulator, receiver
C2860_RS10340	COG0840	transmembrane signaling receptor activity
C2860_RS10390	COG2022	thiamine diphosphate biosynthetic process
C2860_RS10395	COG1324	tolerance protein
C2860_RS10400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2860_RS10400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2860_RS10410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2860_RS10425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2860_RS10430	COG0575	Belongs to the CDS family
C2860_RS10455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2860_RS10460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2860_RS10465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2860_RS10470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2860_RS10480	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2860_RS10485	COG0746	molybdenum cofactor guanylyltransferase activity
C2860_RS10490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2860_RS10495	COG1393	Belongs to the ArsC family
C2860_RS10510	COG2828	Protein conserved in bacteria
C2860_RS10515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2860_RS10525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2860_RS10535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2860_RS10540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C2860_RS10545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2860_RS10550	COG0560	Phosphoserine phosphatase
C2860_RS10560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2860_RS10565	COG0786	glutamate:sodium symporter activity
C2860_RS10585	COG0736	holo-[acyl-carrier-protein] synthase activity
C2860_RS10595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2860_RS10605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2860_RS10645	COG2824	Alkylphosphonate utilization operon protein PhnA
C2860_RS10650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2860_RS10655	COG2203	Gaf domain
C2860_RS10655	COG2200	EAL domain
C2860_RS10655	COG2199	diguanylate cyclase activity
C2860_RS10660	COG0573	inorganic phosphate transmembrane transporter activity
C2860_RS10665	COG0581	inorganic phosphate transmembrane transporter activity
C2860_RS10675	COG0704	Plays a role in the regulation of phosphate uptake
C2860_RS10685	COG0745	RESPONSE REGULATOR receiver
C2860_RS10690	COG5002	protein histidine kinase activity
C2860_RS10695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2860_RS10700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2860_RS10705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2860_RS10720	COG0546	phosphoglycolate phosphatase activity
C2860_RS10745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2860_RS10750	COG1854	S-ribosylhomocysteine lyase activity
C2860_RS10760	COG1686	Belongs to the peptidase S11 family
C2860_RS10770	COG5002	protein histidine kinase activity
C2860_RS10775	COG0646	methionine synthase
C2860_RS10775	COG1410	methionine synthase
C2860_RS10800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2860_RS10800	COG0140	phosphoribosyl-ATP diphosphatase activity
C2860_RS10810	COG0489	protein tyrosine kinase activity
C2860_RS10815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2860_RS10825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2860_RS10825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2860_RS10835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2860_RS10840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2860_RS10845	COG0268	Binds directly to 16S ribosomal RNA
C2860_RS10850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2860_RS10855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2860_RS10860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2860_RS10870	COG0540	Belongs to the ATCase OTCase family
C2860_RS10875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2860_RS10880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2860_RS10885	COG0505	Belongs to the CarA family
C2860_RS10895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2860_RS10900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2860_RS10905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2860_RS10945	COG4895	conserved protein (DUF2196)
C2860_RS10950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2860_RS10955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2860_RS10960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2860_RS10965	COG0237	dephospho-CoA kinase activity
C2860_RS10980	COG0504	CTP synthase activity
C2860_RS10985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2860_RS10985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2860_RS11000	COG0693	protein deglycase activity
C2860_RS11005	COG0587	DNA-directed DNA polymerase activity
C2860_RS11010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2860_RS11025	COG0315	cyclic pyranopterin monophosphate synthase activity
C2860_RS11030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2860_RS11035	COG0428	transporter
C2860_RS11120	COG0109	protoheme IX farnesyltransferase activity
C2860_RS11130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2860_RS11135	COG0254	rRNA binding
C2860_RS11140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2860_RS11145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2860_RS11160	COG0436	Aminotransferase
C2860_RS11165	COG0460	homoserine dehydrogenase
C2860_RS11170	COG0564	pseudouridine synthase activity
C2860_RS11175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2860_RS11180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2860_RS11185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2860_RS11190	COG2885	chlorophyll binding
C2860_RS11190	COG3047	cAMP biosynthetic process
C2860_RS11200	COG4206	TonB-dependent receptor
C2860_RS11235	COG0604	alcohol dehydrogenase
C2860_RS11240	COG1733	regulation of RNA biosynthetic process
C2860_RS11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2860_RS11250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2860_RS11265	COG1620	l-lactate permease
C2860_RS11275	COG0745	RESPONSE REGULATOR receiver
C2860_RS11280	COG3852	Histidine kinase
C2860_RS11290	COG1556	Lactate utilization protein
C2860_RS11295	COG1139	Iron-sulfur cluster binding protein
C2860_RS11300	COG0247	lactate metabolic process
C2860_RS11305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2860_RS11310	COG0511	ligase activity, forming carbon-carbon bonds
C2860_RS11315	COG0439	Biotin carboxylase
C2860_RS11320	COG0513	Belongs to the DEAD box helicase family
C2860_RS11325	COG1278	Cold shock
C2860_RS11340	COG0306	phosphate transporter
C2860_RS11355	COG0367	asparagine synthase
C2860_RS11370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2860_RS11375	COG1981	membrane
C2860_RS11380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2860_RS11380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2860_RS11385	COG1187	pseudouridine synthase activity
C2860_RS11390	COG0517	IMP dehydrogenase activity
C2860_RS11390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2860_RS11395	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2860_RS11400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2860_RS11405	COG0107	imidazoleglycerol-phosphate synthase activity
C2860_RS11420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2860_RS11430	COG0724	RNA recognition motif
C2860_RS11435	COG0745	RESPONSE REGULATOR receiver
C2860_RS11440	COG0642	Histidine kinase
C2860_RS11460	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2860_RS11465	COG2353	YceI-like domain
C2860_RS11500	COG1408	metallophosphoesterase
C2860_RS11515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2860_RS11520	COG4208	sulfate ABC transporter
C2860_RS11525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2860_RS11555	COG1959	2 iron, 2 sulfur cluster binding
C2860_RS11560	COG1217	gtp-binding protein TYPA
C2860_RS11565	COG2391	methyltransferase activity
C2860_RS11570	COG0425	Belongs to the sulfur carrier protein TusA family
C2860_RS11615	COG0745	RESPONSE REGULATOR receiver
C2860_RS11620	COG0642	Histidine kinase
C2860_RS11625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C2860_RS11630	COG2860	membrane
C2860_RS11645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group