locus-tag	class	description
HF896_RS00010	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF896_RS00010	COG1902	pentaerythritol trinitrate reductase activity
HF896_RS00035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF896_RS00035	COG3608	succinylglutamate desuccinylase aspartoacylase
HF896_RS00040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF896_RS00055	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS00065	COG3321	synthase
HF896_RS00065	COG0604	alcohol dehydrogenase
HF896_RS00065	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS00075	COG3608	succinylglutamate desuccinylase aspartoacylase
HF896_RS00075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF896_RS00080	COG0154	amidase activity
HF896_RS00150	COG1053	succinate dehydrogenase
HF896_RS00150	COG3976	FMN-binding domain protein
HF896_RS00150	COG0431	NADPH-dependent FMN reductase
HF896_RS00165	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF896_RS00165	COG1902	pentaerythritol trinitrate reductase activity
HF896_RS00190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF896_RS00190	COG3608	succinylglutamate desuccinylase aspartoacylase
HF896_RS00195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF896_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS00220	COG3321	synthase
HF896_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS00220	COG0604	alcohol dehydrogenase
HF896_RS00230	COG3608	succinylglutamate desuccinylase aspartoacylase
HF896_RS00230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF896_RS00235	COG0154	amidase activity
HF896_RS00290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF896_RS00310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS00320	COG0583	DNA-binding transcription factor activity
HF896_RS00325	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS00335	COG4770	biotin carboxylase activity
HF896_RS00340	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS00350	COG1254	Belongs to the acylphosphatase family
HF896_RS00365	COG1199	ATP-dependent helicase activity
HF896_RS00375	COG0791	NLP P60 protein
HF896_RS00380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HF896_RS00400	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00405	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00420	COG1024	Enoyl-CoA hydratase
HF896_RS00440	COG2974	May be involved in recombination
HF896_RS00445	COG0700	Nucleoside recognition
HF896_RS00460	COG0789	Transcriptional regulator
HF896_RS00495	COG0745	RESPONSE REGULATOR receiver
HF896_RS00500	COG0642	Histidine kinase
HF896_RS00505	COG1902	pentaerythritol trinitrate reductase activity
HF896_RS00525	COG0445	tRNA wobble uridine modification
HF896_RS00535	COG0357	Ribosomal RNA small subunit methyltransferase G
HF896_RS00545	COG1192	Involved in chromosome partitioning
HF896_RS00555	COG1475	DNA binding
HF896_RS00580	COG0668	transmembrane transport
HF896_RS00585	COG0277	FAD linked oxidase domain protein
HF896_RS00595	COG2096	Adenosyltransferase
HF896_RS00600	COG2050	protein possibly involved in aromatic compounds catabolism
HF896_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS00640	COG2233	PERMEase
HF896_RS00655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS00660	COG0583	DNA-binding transcription factor activity
HF896_RS00670	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00675	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00685	COG1183	phosphatidylcholine synthase activity
HF896_RS00690	COG4774	siderophore transport
HF896_RS00705	COG0850	regulation of cytokinetic process
HF896_RS00715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HF896_RS00720	COG0583	DNA-binding transcription factor activity
HF896_RS00725	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS00730	COG4948	Mandelate Racemase Muconate Lactonizing
HF896_RS00735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HF896_RS00740	COG2267	carboxylic ester hydrolase activity
HF896_RS00770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HF896_RS00780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HF896_RS00785	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00800	COG0583	DNA-binding transcription factor activity
HF896_RS00815	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS00820	COG0514	ATP-dependent DNA helicase (RecQ)
HF896_RS00850	COG3256	nitric oxide reductase
HF896_RS00855	COG3604	Transcriptional regulator
HF896_RS00865	COG1760	l-serine dehydratase
HF896_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS00905	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS00950	COG0183	Belongs to the thiolase family
HF896_RS00955	COG1960	acyl-CoA dehydrogenase activity
HF896_RS00965	COG2030	dehydratase
HF896_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS00990	COG0583	DNA-binding transcription factor activity
HF896_RS01000	COG0604	alcohol dehydrogenase
HF896_RS01005	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS01010	COG0583	DNA-binding transcription factor activity
HF896_RS01015	COG0277	FAD linked oxidase domain protein
HF896_RS01020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS01055	COG1960	acyl-CoA dehydrogenase activity
HF896_RS01060	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HF896_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS01070	COG2030	dehydratase
HF896_RS01075	COG1024	Enoyl-CoA hydratase
HF896_RS01080	COG0427	acetyl-CoA hydrolase
HF896_RS01085	COG0183	Belongs to the thiolase family
HF896_RS01110	COG0583	DNA-binding transcription factor activity
HF896_RS01120	COG1473	amidohydrolase
HF896_RS01130	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS01145	COG1473	amidohydrolase
HF896_RS01160	COG1960	acyl-CoA dehydrogenase activity
HF896_RS01185	COG1960	acyl-CoA dehydrogenase activity
HF896_RS01190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS01195	COG1960	acyl-CoA dehydrogenase activity
HF896_RS01200	COG1024	Enoyl-CoA hydratase
HF896_RS01225	COG0583	DNA-binding transcription factor activity
HF896_RS01230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS01235	COG0583	DNA-binding transcription factor activity
HF896_RS01250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HF896_RS01260	COG3204	pilus organization
HF896_RS01265	COG0646	methionine synthase
HF896_RS01265	COG1410	methionine synthase
HF896_RS01290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HF896_RS01310	COG0683	leucine binding
HF896_RS01345	COG0606	chelatase, subunit chli
HF896_RS01355	COG0347	Belongs to the P(II) protein family
HF896_RS01360	COG0004	ammonium transporteR
HF896_RS01370	COG2084	Dehydrogenase
HF896_RS01400	COG2267	carboxylic ester hydrolase activity
HF896_RS01410	COG3180	Ammonia monooxygenase
HF896_RS01415	COG2079	MmgE PrpD family protein
HF896_RS01435	COG0277	FAD linked oxidase domain protein
HF896_RS01445	COG0247	lactate metabolic process
HF896_RS01460	COG0477	Major facilitator Superfamily
HF896_RS01465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF896_RS01470	COG1858	cytochrome C peroxidase
HF896_RS01475	COG0625	glutathione transferase activity
HF896_RS01490	COG0154	amidase activity
HF896_RS01520	COG1442	glycosyl transferase family 8
HF896_RS01520	COG1216	Glycosyl transferase, family 2
HF896_RS01540	COG0477	Major facilitator Superfamily
HF896_RS01545	COG2258	MOSC domain
HF896_RS01565	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS01580	COG2205	protein histidine kinase activity
HF896_RS01585	COG0745	RESPONSE REGULATOR receiver
HF896_RS01605	COG0501	Belongs to the peptidase M48B family
HF896_RS01695	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HF896_RS01720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF896_RS01725	COG1414	Transcriptional regulator
HF896_RS01745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS01750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS01770	COG3386	PFAM SMP-30 Gluconolaconase
HF896_RS01780	COG2084	Dehydrogenase
HF896_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS01790	COG1414	Transcriptional regulator
HF896_RS01840	COG1960	acyl-CoA dehydrogenase activity
HF896_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS01855	COG0708	Exodeoxyribonuclease III
HF896_RS01860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HF896_RS01870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF896_RS01875	COG0154	amidase activity
HF896_RS01880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF896_RS01885	COG1077	Cell shape determining protein MreB Mrl
HF896_RS01895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HF896_RS01900	COG0768	penicillin binding
HF896_RS01910	COG0730	response to heat
HF896_RS01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HF896_RS01925	COG1127	ABC transporter
HF896_RS01930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HF896_RS01930	COG3008	intermembrane lipid transfer
HF896_RS01940	COG0583	DNA-binding transcription factor activity
HF896_RS01945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF896_RS01955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS01960	COG2095	MarC family integral membrane protein
HF896_RS01965	COG0412	Dienelactone hydrolase
HF896_RS01990	COG0598	Magnesium transport protein CorA
HF896_RS02020	COG2945	thiolester hydrolase activity
HF896_RS02025	COG1686	Belongs to the peptidase S11 family
HF896_RS02030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HF896_RS02035	COG0049	tRNA binding
HF896_RS02040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF896_RS02045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF896_RS02050	COG0051	transcription antitermination factor activity, RNA binding
HF896_RS02055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF896_RS02060	COG0088	Forms part of the polypeptide exit tunnel
HF896_RS02065	COG0089	rRNA binding
HF896_RS02070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF896_RS02075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HF896_RS02080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HF896_RS02085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF896_RS02090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HF896_RS02095	COG0255	Belongs to the universal ribosomal protein uL29 family
HF896_RS02100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HF896_RS02105	COG0678	peroxiredoxin activity
HF896_RS02105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HF896_RS02110	COG0456	acetyltransferase
HF896_RS02120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HF896_RS02135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HF896_RS02140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HF896_RS02145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HF896_RS02150	COG0321	lipoyl(octanoyl) transferase activity
HF896_RS02155	COG2921	Belongs to the UPF0250 family
HF896_RS02165	COG0356	it plays a direct role in the translocation of protons across the membrane
HF896_RS02175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HF896_RS02180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF896_RS02185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HF896_RS02190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF896_RS02195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HF896_RS02200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF896_RS02250	COG3245	cytochrome
HF896_RS02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF896_RS02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF896_RS02295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF896_RS02305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HF896_RS02315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HF896_RS02320	COG0081	regulation of translation
HF896_RS02325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF896_RS02330	COG0222	ribosome binding
HF896_RS02335	COG0085	RNA polymerase activity
HF896_RS02340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HF896_RS02350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF896_RS02350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HF896_RS02360	COG5000	phosphorelay sensor kinase activity
HF896_RS02365	COG2204	response regulator
HF896_RS02400	COG4584	PFAM Integrase catalytic
HF896_RS02405	COG1484	DNA-dependent DNA replication
HF896_RS02445	COG1111	helicase
HF896_RS02445	COG1205	dead DEAH box helicase
HF896_RS02455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HF896_RS02460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HF896_RS02465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HF896_RS02515	COG0582	viral genome integration into host DNA
HF896_RS02590	COG5489	Protein of unknown function (DUF736)
HF896_RS02595	COG0484	heat shock protein binding
HF896_RS02600	COG3328	transposase activity
HF896_RS02640	COG1192	Involved in chromosome partitioning
HF896_RS02665	COG2132	Multicopper oxidase
HF896_RS02675	COG2205	protein histidine kinase activity
HF896_RS02685	COG2132	Multicopper oxidase
HF896_RS02720	COG2010	Cytochrome c
HF896_RS02755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF896_RS02760	COG0583	DNA-binding transcription factor activity
HF896_RS02780	COG4962	Type ii secretion system protein e
HF896_RS02785	COG3838	Conjugal transfer protein Trbc
HF896_RS02795	COG3451	type IV secretory pathway VirB4
HF896_RS02805	COG3846	protein secretion by the type IV secretion system
HF896_RS02820	COG2948	multi-organism process
HF896_RS02865	COG3311	Transcriptional regulator
HF896_RS02890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HF896_RS02905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HF896_RS02910	COG0792	nuclease activity
HF896_RS02915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HF896_RS02925	COG2084	Dehydrogenase
HF896_RS02935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF896_RS02945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HF896_RS02965	COG0277	FAD linked oxidase domain protein
HF896_RS02970	COG0583	DNA-binding transcription factor activity
HF896_RS02980	COG5001	Diguanylate cyclase
HF896_RS02995	COG4585	Histidine kinase
HF896_RS03000	COG2197	response regulator
HF896_RS03010	COG2223	nitrite transmembrane transporter activity
HF896_RS03015	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HF896_RS03020	COG1140	nitrate reductase beta subunit
HF896_RS03025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HF896_RS03030	COG2181	nitrate reductase activity
HF896_RS03040	COG0288	reversible hydration of carbon dioxide
HF896_RS03055	COG3945	hemerythrin HHE cation binding domain
HF896_RS03080	COG0243	molybdopterin cofactor binding
HF896_RS03090	COG2301	Belongs to the HpcH HpaI aldolase family
HF896_RS03095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS03100	COG2030	dehydratase
HF896_RS03110	COG2030	dehydratase
HF896_RS03130	COG1473	amidohydrolase
HF896_RS03145	COG2818	Glycosylase
HF896_RS03155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HF896_RS03195	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS03205	COG1022	Amp-dependent synthetase and ligase
HF896_RS03210	COG3267	Type II secretory pathway component ExeA
HF896_RS03210	COG3409	Peptidoglycan-binding domain 1 protein
HF896_RS03220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF896_RS03225	COG1187	pseudouridine synthase activity
HF896_RS03230	COG0326	Molecular chaperone. Has ATPase activity
HF896_RS03240	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS03245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HF896_RS03260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS03275	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS03300	COG1131	(ABC) transporter
HF896_RS03305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HF896_RS03310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HF896_RS03315	COG3300	MHYT domain
HF896_RS03315	COG5001	Diguanylate cyclase
HF896_RS03320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HF896_RS03325	COG1490	D-aminoacyl-tRNA deacylase activity
HF896_RS03330	COG0730	response to heat
HF896_RS03345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS03350	COG0604	alcohol dehydrogenase
HF896_RS03355	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS03360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HF896_RS03365	COG1702	phosphate starvation-inducible protein PhoH
HF896_RS03370	COG0632	four-way junction helicase activity
HF896_RS03385	COG0443	Heat shock 70 kDa protein
HF896_RS03395	COG2255	four-way junction helicase activity
HF896_RS03400	COG1285	pathogenesis
HF896_RS03430	COG0037	tRNA processing
HF896_RS03465	COG1940	carbohydrate kinase activity
HF896_RS03470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HF896_RS03475	COG3387	PFAM Glycoside hydrolase 15-related
HF896_RS03480	COG1877	trehalose-phosphatase activity
HF896_RS03490	COG0617	tRNA 3'-terminal CCA addition
HF896_RS03510	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS03525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HF896_RS03530	COG0739	heme binding
HF896_RS03530	COG1196	nuclear chromosome segregation
HF896_RS03530	COG0741	lytic transglycosylase activity
HF896_RS03545	COG3128	pkhd-type hydroxylase
HF896_RS03555	COG4774	siderophore transport
HF896_RS03565	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS03580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF896_RS03585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HF896_RS03600	COG1522	sequence-specific DNA binding
HF896_RS03610	COG3186	Phenylalanine-4-hydroxylase
HF896_RS03620	COG0022	dehydrogenase e1 component
HF896_RS03635	COG0752	glycyl-tRNA synthetase alpha subunit
HF896_RS03640	COG0751	glycine-tRNA ligase activity
HF896_RS03645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HF896_RS03650	COG0204	Acyl-transferase
HF896_RS03665	COG1652	LysM domain
HF896_RS03670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HF896_RS03715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HF896_RS03745	COG3156	type II secretion system protein K
HF896_RS03765	COG1450	Type ii and iii secretion system protein
HF896_RS03820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF896_RS03825	COG1196	nuclear chromosome segregation
HF896_RS03825	COG0739	heme binding
HF896_RS03825	COG0741	lytic transglycosylase activity
HF896_RS03835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF896_RS03850	COG1960	acyl-CoA dehydrogenase activity
HF896_RS03860	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS03860	COG1024	Enoyl-CoA hydratase
HF896_RS03865	COG0183	Belongs to the thiolase family
HF896_RS03875	COG1024	Enoyl-CoA hydratase
HF896_RS03890	COG5265	(ABC) transporter
HF896_RS03915	COG0583	DNA-binding transcription factor activity
HF896_RS03925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF896_RS03935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HF896_RS03940	COG0583	DNA-binding transcription factor activity
HF896_RS03945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS03950	COG0765	amino acid transport
HF896_RS03955	COG0765	amino acid transport
HF896_RS03960	COG1126	abc transporter atp-binding protein
HF896_RS03965	COG2423	ornithine cyclodeaminase activity
HF896_RS03975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HF896_RS03985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HF896_RS03995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HF896_RS04000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HF896_RS04005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HF896_RS04015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HF896_RS04020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HF896_RS04025	COG0316	Belongs to the HesB IscA family
HF896_RS04040	COG4584	PFAM Integrase catalytic
HF896_RS04045	COG1484	DNA-dependent DNA replication
HF896_RS04110	COG5489	Protein of unknown function (DUF736)
HF896_RS04145	COG1192	Involved in chromosome partitioning
HF896_RS04170	COG0789	Transcriptional regulator
HF896_RS04190	COG0642	Histidine kinase
HF896_RS04225	COG0583	DNA-binding transcription factor activity
HF896_RS04260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HF896_RS04265	COG0739	heme binding
HF896_RS04270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HF896_RS04275	COG0583	DNA-binding transcription factor activity
HF896_RS04280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF896_RS04285	COG2205	protein histidine kinase activity
HF896_RS04300	COG1522	sequence-specific DNA binding
HF896_RS04315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HF896_RS04320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HF896_RS04325	COG0745	RESPONSE REGULATOR receiver
HF896_RS04330	COG5002	protein histidine kinase activity
HF896_RS04360	COG0489	protein tyrosine kinase activity
HF896_RS04370	COG3267	Type II secretory pathway component ExeA
HF896_RS04370	COG3409	Peptidoglycan-binding domain 1 protein
HF896_RS04395	COG0367	asparagine synthase
HF896_RS04410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HF896_RS04415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HF896_RS04420	COG0438	transferase activity, transferring glycosyl groups
HF896_RS04450	COG1216	Glycosyl transferase, family 2
HF896_RS04495	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS04505	COG5002	protein histidine kinase activity
HF896_RS04505	COG3850	Histidine kinase
HF896_RS04510	COG2204	response regulator
HF896_RS04525	COG2076	Multidrug Resistance protein
HF896_RS04530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF896_RS04530	COG0546	phosphoglycolate phosphatase activity
HF896_RS04540	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS04550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HF896_RS04560	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS04585	COG3045	CreA protein
HF896_RS04590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HF896_RS04590	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF896_RS04595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HF896_RS04595	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF896_RS04600	COG1132	(ABC) transporter
HF896_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HF896_RS04700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HF896_RS04705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HF896_RS04710	COG1765	OsmC-like protein
HF896_RS04715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HF896_RS04735	COG1473	amidohydrolase
HF896_RS04740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF896_RS04745	COG0444	Belongs to the ABC transporter superfamily
HF896_RS04750	COG4608	Belongs to the ABC transporter superfamily
HF896_RS04755	COG1881	PFAM PEBP family protein
HF896_RS04760	COG0837	glucose binding
HF896_RS04760	COG1737	Transcriptional regulator
HF896_RS04765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HF896_RS04770	COG0166	Belongs to the GPI family
HF896_RS04775	COG0459	protein refolding
HF896_RS04780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HF896_RS04785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF896_RS04790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HF896_RS04800	COG1560	Kdo2-lipid A biosynthetic process
HF896_RS04805	COG0583	DNA-binding transcription factor activity
HF896_RS04815	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS04820	COG0473	3-isopropylmalate dehydrogenase activity
HF896_RS04830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HF896_RS04840	COG1333	cytochrome c biogenesis protein
HF896_RS04845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HF896_RS04850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HF896_RS04855	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HF896_RS04875	COG1965	Belongs to the frataxin family
HF896_RS04920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HF896_RS04955	COG0067	glutamate synthase
HF896_RS04955	COG0070	glutamate synthase
HF896_RS04955	COG0069	glutamate synthase activity
HF896_RS04970	COG0765	amino acid transport
HF896_RS04985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HF896_RS04990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HF896_RS04995	COG1127	ABC transporter
HF896_RS05000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HF896_RS05005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HF896_RS05030	COG1131	(ABC) transporter
HF896_RS05035	COG0842	Transport permease protein
HF896_RS05040	COG5007	Belongs to the BolA IbaG family
HF896_RS05045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HF896_RS05050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HF896_RS05070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HF896_RS05075	COG0131	Imidazoleglycerol-phosphate dehydratase
HF896_RS05085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HF896_RS05100	COG0438	transferase activity, transferring glycosyl groups
HF896_RS05130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HF896_RS05135	COG0107	imidazoleglycerol-phosphate synthase activity
HF896_RS05140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HF896_RS05145	COG0140	phosphoribosyl-ATP diphosphatase activity
HF896_RS05160	COG0537	adenosine 5'-monophosphoramidase activity
HF896_RS05165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF896_RS05170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF896_RS05175	COG0805	protein transport
HF896_RS05180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF896_RS05185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HF896_RS05190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HF896_RS05195	COG1970	mechanosensitive ion channel activity
HF896_RS05200	COG0723	plastoquinol--plastocyanin reductase activity
HF896_RS05205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF896_RS05210	COG2857	Cytochrome c1
HF896_RS05215	COG0625	glutathione transferase activity
HF896_RS05220	COG2969	positive regulation of protein catabolic process
HF896_RS05235	COG0653	protein targeting
HF896_RS05240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HF896_RS05250	COG0494	nUDIX hydrolase
HF896_RS05255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HF896_RS05260	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HF896_RS05265	COG0237	dephospho-CoA kinase activity
HF896_RS05285	COG0582	viral genome integration into host DNA
HF896_RS05360	COG0142	geranyltranstransferase activity
HF896_RS05365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HF896_RS05370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HF896_RS05375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF896_RS05380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HF896_RS05385	COG0494	nUDIX hydrolase
HF896_RS05390	COG0442	prolyl-tRNA aminoacylation
HF896_RS05400	COG1253	flavin adenine dinucleotide binding
HF896_RS05405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF896_RS05410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HF896_RS05415	COG2890	protein-(glutamine-N5) methyltransferase activity
HF896_RS05420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF896_RS05425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HF896_RS05450	COG3264	Mechanosensitive ion channel
HF896_RS05450	COG1511	domain protein
HF896_RS05455	COG0584	glycerophosphoryl diester phosphodiesterase
HF896_RS05460	COG3842	ATPase activity
HF896_RS05465	COG0395	ABC-type sugar transport system, permease component
HF896_RS05470	COG1175	transmembrane transport
HF896_RS05475	COG1653	transport
HF896_RS05480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HF896_RS05500	COG2226	methyltransferase
HF896_RS05515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HF896_RS05535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HF896_RS05550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF896_RS05555	COG0302	gtp cyclohydrolase
HF896_RS05570	COG4191	Histidine kinase
HF896_RS05575	COG4566	intracellular signal transduction
HF896_RS05580	COG3258	Cytochrome c
HF896_RS05595	COG1280	lysine exporter protein (LysE YggA)
HF896_RS05600	COG0154	amidase activity
HF896_RS05610	COG4608	Belongs to the ABC transporter superfamily
HF896_RS05615	COG0444	Belongs to the ABC transporter superfamily
HF896_RS05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF896_RS05630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HF896_RS05635	COG0193	aminoacyl-tRNA hydrolase activity
HF896_RS05640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HF896_RS05645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HF896_RS05655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HF896_RS05670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HF896_RS05690	COG1660	Displays ATPase and GTPase activities
HF896_RS05695	COG0497	DNA recombination
HF896_RS05700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HF896_RS05705	COG1420	regulation of RNA biosynthetic process
HF896_RS05725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HF896_RS05730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HF896_RS05750	COG1561	YicC-like family, N-terminal region
HF896_RS05820	COG1222	aaa ATPase
HF896_RS05850	COG0194	GDP metabolic process
HF896_RS05855	COG1758	RNA polymerase activity
HF896_RS05860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HF896_RS05880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HF896_RS05885	COG1185	polyribonucleotide nucleotidyltransferase activity
HF896_RS05890	COG3321	synthase
HF896_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS05890	COG0604	alcohol dehydrogenase
HF896_RS05895	COG0149	triose-phosphate isomerase activity
HF896_RS05910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF896_RS05915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF896_RS05920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF896_RS05925	COG0649	NAD binding
HF896_RS05940	COG1034	ATP synthesis coupled electron transport
HF896_RS05945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HF896_RS05950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF896_RS05960	COG0713	ATP synthesis coupled electron transport
HF896_RS05975	COG1007	ATP synthesis coupled electron transport
HF896_RS05995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HF896_RS06000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HF896_RS06010	COG0586	Pfam SNARE associated Golgi protein
HF896_RS06015	COG0402	S-adenosylhomocysteine deaminase activity
HF896_RS06030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HF896_RS06035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HF896_RS06045	COG0860	N-Acetylmuramoyl-L-alanine amidase
HF896_RS06050	COG0802	atpase or kinase
HF896_RS06055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HF896_RS06075	COG4974	Belongs to the 'phage' integrase family
HF896_RS06080	COG0840	transmembrane signaling receptor activity
HF896_RS06090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HF896_RS06095	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HF896_RS06100	COG2833	Protein of unknown function (DUF455)
HF896_RS06110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HF896_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS06135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HF896_RS06140	COG0148	phosphopyruvate hydratase activity
HF896_RS06150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HF896_RS06155	COG0504	CTP synthase activity
HF896_RS06160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HF896_RS06170	COG0756	dUTP diphosphatase activity
HF896_RS06175	COG1047	Peptidyl-prolyl cis-trans
HF896_RS06180	COG2850	peptidyl-arginine hydroxylation
HF896_RS06195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HF896_RS06200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS06255	COG1722	exodeoxyribonuclease VII activity
HF896_RS06265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HF896_RS06270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HF896_RS06275	COG1201	RNA secondary structure unwinding
HF896_RS06280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF896_RS06300	COG1045	serine acetyltransferase
HF896_RS06310	COG1063	alcohol dehydrogenase
HF896_RS06315	COG0521	Mo-molybdopterin cofactor biosynthetic process
HF896_RS06320	COG3028	Belongs to the UPF0307 family
HF896_RS06325	COG0312	modulator of DNA gyrase
HF896_RS06370	COG4584	PFAM Integrase catalytic
HF896_RS06375	COG1484	DNA-dependent DNA replication
HF896_RS06390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HF896_RS06415	COG0114	fumarate hydratase activity
HF896_RS06420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF896_RS06425	COG2113	Glycine betaine
HF896_RS06430	COG4176	ABC-type proline glycine betaine transport system permease component
HF896_RS06435	COG4175	Glycine betaine
HF896_RS06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS06445	COG2304	oxidoreductase activity
HF896_RS06455	COG0714	Associated with various cellular activities
HF896_RS06460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF896_RS06470	COG0640	Transcriptional regulator
HF896_RS06480	COG0084	hydrolase, TatD family'
HF896_RS06490	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HF896_RS06495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HF896_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS06525	COG0697	spore germination
HF896_RS06540	COG0583	DNA-binding transcription factor activity
HF896_RS06555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HF896_RS06560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HF896_RS06570	COG4149	molybdate abc transporter
HF896_RS06575	COG1840	ABC-type Fe3 transport system, periplasmic component
HF896_RS06580	COG1609	Transcriptional regulator
HF896_RS06585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF896_RS06590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF896_RS06595	COG0196	riboflavin kinase activity
HF896_RS06605	COG1960	acyl-CoA dehydrogenase activity
HF896_RS06610	COG1960	acyl-CoA dehydrogenase activity
HF896_RS06615	COG3132	Protein of unknown function, DUF480
HF896_RS06620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HF896_RS06625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HF896_RS06625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF896_RS06630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF896_RS06635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HF896_RS06640	COG0492	ferredoxin-NADP+ reductase activity
HF896_RS06645	COG1674	ftsk spoiiie
HF896_RS06650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HF896_RS06655	COG1575	Belongs to the MenA family. Type 1 subfamily
HF896_RS06660	COG1573	uracil-dna glycosylase
HF896_RS06665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HF896_RS06670	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS06700	COG1392	Phosphate transport regulator
HF896_RS06705	COG0306	phosphate transporter
HF896_RS06720	COG0228	four-way junction DNA binding
HF896_RS06725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HF896_RS06730	COG0336	Belongs to the RNA methyltransferase TrmD family
HF896_RS06735	COG0335	large ribosomal subunit rRNA binding
HF896_RS06740	COG0494	nUDIX hydrolase
HF896_RS06745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HF896_RS06750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HF896_RS06755	COG0659	secondary active sulfate transmembrane transporter activity
HF896_RS06760	COG1162	GTPase activity
HF896_RS06765	COG2154	pterin-4-alpha-carbinolamine dehydratase
HF896_RS06770	COG0501	Belongs to the peptidase M48B family
HF896_RS06775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HF896_RS06785	COG0513	Belongs to the DEAD box helicase family
HF896_RS06790	COG3447	MASE1 domain protein
HF896_RS06790	COG5002	protein histidine kinase activity
HF896_RS06790	COG5001	Diguanylate cyclase
HF896_RS06795	COG2814	Major facilitator Superfamily
HF896_RS06830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HF896_RS06840	COG4771	TonB-dependent receptor
HF896_RS06875	COG0516	GMP reductase activity
HF896_RS06880	COG0210	DNA helicase
HF896_RS06890	COG5001	Diguanylate cyclase
HF896_RS06890	COG4251	negative regulation of phosphorylation
HF896_RS06890	COG3706	GGDEF domain
HF896_RS06890	COG2203	Gaf domain
HF896_RS06900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HF896_RS06925	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS06940	COG0583	DNA-binding transcription factor activity
HF896_RS06950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS06955	COG1024	Enoyl-CoA hydratase
HF896_RS06960	COG0412	Dienelactone hydrolase
HF896_RS06975	COG0560	Phosphoserine phosphatase
HF896_RS06990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HF896_RS06995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HF896_RS06995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF896_RS07000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF896_RS07005	COG2205	protein histidine kinase activity
HF896_RS07010	COG0745	RESPONSE REGULATOR receiver
HF896_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS07030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HF896_RS07045	COG0724	RNA recognition motif
HF896_RS07050	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HF896_RS07055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF896_RS07075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF896_RS07080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS07090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HF896_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS07115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF896_RS07130	COG1122	ATPase activity
HF896_RS07210	COG0071	Belongs to the small heat shock protein (HSP20) family
HF896_RS07215	COG1136	(ABC) transporter
HF896_RS07220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HF896_RS07230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS07235	COG0537	adenosine 5'-monophosphoramidase activity
HF896_RS07250	COG5002	protein histidine kinase activity
HF896_RS07250	COG5001	Diguanylate cyclase
HF896_RS07250	COG3447	MASE1 domain protein
HF896_RS07255	COG1129	ABC transporter
HF896_RS07280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS07285	COG1126	abc transporter atp-binding protein
HF896_RS07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS07310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HF896_RS07320	COG4166	transmembrane transport
HF896_RS07325	COG4608	Belongs to the ABC transporter superfamily
HF896_RS07330	COG0444	Belongs to the ABC transporter superfamily
HF896_RS07335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF896_RS07340	COG0601	transmembrane transport
HF896_RS07350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HF896_RS07355	COG0727	PFAM Uncharacterised protein family (UPF0153)
HF896_RS07375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HF896_RS07390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HF896_RS07395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF896_RS07415	COG0268	Binds directly to 16S ribosomal RNA
HF896_RS07420	COG0728	peptidoglycan biosynthetic process
HF896_RS07430	COG0589	response to stress
HF896_RS07440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HF896_RS07445	COG0405	Gamma-glutamyltransferase
HF896_RS07450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF896_RS07460	COG0617	tRNA 3'-terminal CCA addition
HF896_RS07465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HF896_RS07470	COG0463	Glycosyl transferase, family 2
HF896_RS07475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HF896_RS07505	COG0583	DNA-binding transcription factor activity
HF896_RS07510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HF896_RS07535	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS07540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS07545	COG1960	acyl-CoA dehydrogenase activity
HF896_RS07550	COG0583	DNA-binding transcription factor activity
HF896_RS07590	COG0513	Belongs to the DEAD box helicase family
HF896_RS07595	COG0488	(ABC) transporter
HF896_RS07605	COG3191	aminopeptidase activity
HF896_RS07635	COG0789	Transcriptional regulator
HF896_RS07660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HF896_RS07660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HF896_RS07675	COG0052	Belongs to the universal ribosomal protein uS2 family
HF896_RS07680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HF896_RS07685	COG0528	UMP kinase activity
HF896_RS07690	COG0233	cytoplasmic translational termination
HF896_RS07695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HF896_RS07700	COG0575	Belongs to the CDS family
HF896_RS07705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HF896_RS07710	COG0750	zinc metalloprotease
HF896_RS07725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF896_RS07730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF896_RS07735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF896_RS07740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF896_RS07745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF896_RS07750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF896_RS07760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HF896_RS07765	COG0308	aminopeptidase N
HF896_RS07795	COG3842	ATPase activity
HF896_RS07800	COG0667	Aldo Keto reductase
HF896_RS07805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HF896_RS07810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HF896_RS07820	COG3577	Aspartyl protease
HF896_RS07825	COG1666	GTP binding
HF896_RS07830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HF896_RS07840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HF896_RS07845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HF896_RS07850	COG0145	ligase activity
HF896_RS07855	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HF896_RS07860	COG4647	ligase activity
HF896_RS07865	COG3284	Transcriptional regulator
HF896_RS07870	COG0137	argininosuccinate synthase activity
HF896_RS07875	COG3123	guanosine phosphorylase activity
HF896_RS07885	COG1393	Belongs to the ArsC family
HF896_RS07890	COG0285	dihydrofolate synthase activity
HF896_RS07900	COG1286	toxin biosynthetic process
HF896_RS07915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF896_RS08000	COG3547	Transposase (IS116 IS110 IS902 family)
HF896_RS08005	COG2855	membrane
HF896_RS08025	COG1053	succinate dehydrogenase
HF896_RS08065	COG2855	membrane
HF896_RS08080	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS08095	COG0583	DNA-binding transcription factor activity
HF896_RS08115	COG0765	amino acid transport
HF896_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF896_RS08125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS08130	COG0582	viral genome integration into host DNA
HF896_RS08170	COG1840	ABC-type Fe3 transport system, periplasmic component
HF896_RS08185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HF896_RS08195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS08215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HF896_RS08230	COG2212	antiporter activity
HF896_RS08240	COG0651	ATP synthesis coupled electron transport
HF896_RS08245	COG1006	Multisubunit Na H antiporter MnhC subunit
HF896_RS08250	COG2111	Na H antiporter
HF896_RS08250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF896_RS08260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HF896_RS08270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF896_RS08280	COG2917	probably involved in intracellular septation
HF896_RS08285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF896_RS08290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HF896_RS08295	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS08305	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS08315	COG0411	ABC transporter
HF896_RS08325	COG1024	Enoyl-CoA hydratase
HF896_RS08325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS08330	COG0183	Belongs to the thiolase family
HF896_RS08340	COG0765	amino acid transport
HF896_RS08345	COG0765	amino acid transport
HF896_RS08350	COG1960	acyl-CoA dehydrogenase activity
HF896_RS08390	COG1309	transcriptional regulator
HF896_RS08395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF896_RS08425	COG0259	pyridoxamine-phosphate oxidase activity
HF896_RS08450	COG2183	response to ionizing radiation
HF896_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS08480	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS08490	COG1609	Transcriptional regulator
HF896_RS08515	COG3618	amidohydrolase
HF896_RS08550	COG4566	intracellular signal transduction
HF896_RS08560	COG2807	transmembrane transport
HF896_RS08565	COG0590	tRNA wobble adenosine to inosine editing
HF896_RS08575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HF896_RS08580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF896_RS08585	COG0470	DNA polymerase III
HF896_RS08595	COG0084	hydrolase, TatD family'
HF896_RS08615	COG1802	Transcriptional regulator
HF896_RS08620	COG2814	Major facilitator Superfamily
HF896_RS08625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HF896_RS08630	COG4336	lyase activity
HF896_RS08635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HF896_RS08640	COG4770	biotin carboxylase activity
HF896_RS08645	COG1132	(ABC) transporter
HF896_RS08650	COG0823	Involved in the tonB-independent uptake of proteins
HF896_RS08660	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HF896_RS08665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HF896_RS08685	COG1388	LysM domain
HF896_RS08685	COG0741	lytic transglycosylase activity
HF896_RS08690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF896_RS08695	COG2226	methyltransferase
HF896_RS08700	COG0328	RNA-DNA hybrid ribonuclease activity
HF896_RS08705	COG0436	Aminotransferase
HF896_RS08710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS08715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS08715	COG0473	3-isopropylmalate dehydrogenase activity
HF896_RS08720	COG0583	DNA-binding transcription factor activity
HF896_RS08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS08750	COG0303	'Molybdopterin
HF896_RS08760	COG0746	molybdenum cofactor guanylyltransferase activity
HF896_RS08765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HF896_RS08780	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS08790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HF896_RS08795	COG0835	chemotaxis
HF896_RS08800	COG0840	transmembrane signaling receptor activity
HF896_RS08820	COG0347	Belongs to the P(II) protein family
HF896_RS08850	COG1595	DNA-templated transcription, initiation
HF896_RS08855	COG0028	Belongs to the TPP enzyme family
HF896_RS08860	COG0440	acetolactate synthase activity
HF896_RS08865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HF896_RS08870	COG1183	phosphatidylcholine synthase activity
HF896_RS08895	COG0583	DNA-binding transcription factor activity
HF896_RS08905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF896_RS08915	COG1414	Transcriptional regulator
HF896_RS08920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF896_RS08925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HF896_RS08925	COG0506	proline dehydrogenase activity
HF896_RS08925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HF896_RS08945	COG1024	Enoyl-CoA hydratase
HF896_RS08950	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS08965	COG2022	thiamine diphosphate biosynthetic process
HF896_RS08980	COG0351	phosphomethylpyrimidine kinase
HF896_RS08995	COG0492	ferredoxin-NADP+ reductase activity
HF896_RS09000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HF896_RS09010	COG0175	sulfate reduction
HF896_RS09015	COG0175	sulfate reduction
HF896_RS09030	COG0730	response to heat
HF896_RS09035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HF896_RS09035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS09040	COG2860	membrane
HF896_RS09045	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HF896_RS09050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HF896_RS09070	COG0183	Belongs to the thiolase family
HF896_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS09085	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS09100	COG0410	ABC transporter
HF896_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS09135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HF896_RS09160	COG0210	DNA helicase
HF896_RS09170	COG1484	DNA-dependent DNA replication
HF896_RS09175	COG4584	PFAM Integrase catalytic
HF896_RS09195	COG3328	transposase activity
HF896_RS09230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF896_RS09250	COG5377	YqaJ viral recombinase family
HF896_RS09285	COG4983	Phage plasmid primase, P4 family domain protein
HF896_RS09315	COG1002	Type II restriction enzyme, methylase subunits
HF896_RS09345	COG0028	Belongs to the TPP enzyme family
HF896_RS09350	COG0583	DNA-binding transcription factor activity
HF896_RS09365	COG1982	Orn Lys Arg decarboxylase major
HF896_RS09370	COG0861	Integral membrane protein TerC family
HF896_RS09375	COG1793	dna ligase
HF896_RS09380	COG2841	Protein conserved in bacteria
HF896_RS09405	COG4174	ABC transporter (Permease)
HF896_RS09410	COG4239	(ABC) transporter, permease
HF896_RS09415	COG4172	Belongs to the ABC transporter superfamily
HF896_RS09420	COG0589	response to stress
HF896_RS09445	COG0628	permease
HF896_RS09450	COG0567	Dehydrogenase, E1 component
HF896_RS09455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF896_RS09460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF896_RS09465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HF896_RS09475	COG0631	protein serine/threonine phosphatase activity
HF896_RS09480	COG1199	ATP-dependent helicase activity
HF896_RS09495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HF896_RS09500	COG0542	response to heat
HF896_RS09505	COG1609	Transcriptional regulator
HF896_RS09510	COG3265	gluconokinase activity
HF896_RS09515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HF896_RS09520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF896_RS09525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF896_RS09535	COG0800	Aldolase
HF896_RS09550	COG3485	protocatechuate 3,4-dioxygenase
HF896_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS09560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HF896_RS09580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HF896_RS09585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HF896_RS09590	COG0346	lactoylglutathione lyase activity
HF896_RS09610	COG1122	ATPase activity
HF896_RS09620	COG1268	BioY protein
HF896_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS09630	COG0183	Belongs to the thiolase family
HF896_RS09635	COG1643	Atp-dependent helicase
HF896_RS09645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HF896_RS09650	COG0252	asparaginase activity
HF896_RS09655	COG0563	adenylate kinase activity
HF896_RS09660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HF896_RS09665	COG2835	tetraacyldisaccharide 4'-kinase activity
HF896_RS09670	COG1663	tetraacyldisaccharide 4'-kinase activity
HF896_RS09680	COG0811	peptide transport
HF896_RS09685	COG1570	exodeoxyribonuclease VII activity
HF896_RS09690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HF896_RS09735	COG2832	Protein of unknown function (DUF454)
HF896_RS09740	COG0242	peptide deformylase activity
HF896_RS09745	COG2233	PERMEase
HF896_RS09755	COG0024	Methionine aminopeptidase
HF896_RS09760	COG0047	phosphoribosylformylglycinamidine synthase activity
HF896_RS09760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF896_RS09765	COG2354	Protein conserved in bacteria
HF896_RS09770	COG3047	cAMP biosynthetic process
HF896_RS09775	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HF896_RS09780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HF896_RS09790	COG0826	peptidase U32
HF896_RS09805	COG1619	proteins homologs of microcin C7 resistance protein MccF
HF896_RS09825	COG2169	Transcriptional regulator
HF896_RS09840	COG3718	enzyme involved in inositol metabolism
HF896_RS09865	COG0045	succinate-CoA ligase (ADP-forming) activity
HF896_RS09865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HF896_RS09865	COG1042	CoA-binding domain protein
HF896_RS09870	COG0564	pseudouridine synthase activity
HF896_RS09875	COG1802	Transcriptional regulator
HF896_RS09880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HF896_RS09885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF896_RS09890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF896_RS09900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS09905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF896_RS09910	COG3706	GGDEF domain
HF896_RS09915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HF896_RS09920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF896_RS09925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HF896_RS09925	COG0493	'glutamate synthase
HF896_RS09930	COG0583	DNA-binding transcription factor activity
HF896_RS09935	COG1741	Belongs to the pirin family
HF896_RS09940	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HF896_RS09945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HF896_RS09950	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS09955	COG4948	Mandelate Racemase Muconate Lactonizing
HF896_RS09960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS09970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS09975	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS09985	COG4948	Mandelate Racemase Muconate Lactonizing
HF896_RS09990	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS09995	COG2721	sulfolactate sulfo-lyase activity
HF896_RS10005	COG0133	tryptophan synthase activity
HF896_RS10035	COG1960	acyl-CoA dehydrogenase activity
HF896_RS10050	COG0583	DNA-binding transcription factor activity
HF896_RS10055	COG2133	pyrroloquinoline quinone binding
HF896_RS10065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS10075	COG3706	GGDEF domain
HF896_RS10090	COG0626	cystathionine gamma-synthase activity
HF896_RS10105	COG4181	ATPase activity
HF896_RS10110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HF896_RS10115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF896_RS10150	COG5507	3-demethylubiquinone-9 3-methyltransferase
HF896_RS10160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HF896_RS10175	COG2076	Multidrug Resistance protein
HF896_RS10195	COG0670	Belongs to the BI1 family
HF896_RS10200	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HF896_RS10250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HF896_RS10255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HF896_RS10260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HF896_RS10265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HF896_RS10270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HF896_RS10275	COG0072	phenylalanine-tRNA ligase activity
HF896_RS10275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF896_RS10280	COG0776	regulation of translation
HF896_RS10285	COG0789	Transcriptional regulator
HF896_RS10295	COG0505	Belongs to the CarA family
HF896_RS10300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HF896_RS10305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF896_RS10320	COG1534	Rna-binding protein
HF896_RS10325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HF896_RS10330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF896_RS10340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF896_RS10370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HF896_RS10375	COG0573	inorganic phosphate transmembrane transporter activity
HF896_RS10380	COG0581	inorganic phosphate transmembrane transporter activity
HF896_RS10385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HF896_RS10390	COG0704	Plays a role in the regulation of phosphate uptake
HF896_RS10405	COG0534	Mate efflux family protein
HF896_RS10415	COG0254	rRNA binding
HF896_RS10420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HF896_RS10430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HF896_RS10460	COG4206	TonB-dependent receptor
HF896_RS10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HF896_RS10480	COG1120	ATPase activity
HF896_RS10500	COG4149	molybdate abc transporter
HF896_RS10520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HF896_RS10525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF896_RS10530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF896_RS10540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HF896_RS10545	COG2011	ABC-type metal ion transport system permease component
HF896_RS10550	COG1464	Belongs to the NlpA lipoprotein family
HF896_RS10560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HF896_RS10575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HF896_RS10585	COG4208	sulfate ABC transporter
HF896_RS10590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HF896_RS10595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HF896_RS10600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF896_RS10605	COG2186	Transcriptional regulator
HF896_RS10615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS10620	COG0683	leucine binding
HF896_RS10650	COG3473	Maleate cis-trans isomerase
HF896_RS10655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS10665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF896_RS10665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HF896_RS10670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HF896_RS10670	COG2755	lipolytic protein G-D-S-L family
HF896_RS10690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF896_RS10700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HF896_RS10705	COG0719	Fe-S assembly protein
HF896_RS10710	COG0396	ATPase activity
HF896_RS10720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HF896_RS10725	COG0822	iron-sulfur transferase activity
HF896_RS10745	COG2081	HI0933 family
HF896_RS10750	COG1607	acyl-coa hydrolase
HF896_RS10760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HF896_RS10770	COG2223	nitrite transmembrane transporter activity
HF896_RS10775	COG0243	molybdopterin cofactor binding
HF896_RS10785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HF896_RS10790	COG1538	Outer membrane efflux protein
HF896_RS10795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF896_RS10810	COG0617	tRNA 3'-terminal CCA addition
HF896_RS10810	COG0517	IMP dehydrogenase activity
HF896_RS10810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HF896_RS10815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF896_RS10825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF896_RS10830	COG0577	efflux transmembrane transporter activity
HF896_RS10830	COG1136	(ABC) transporter
HF896_RS10835	COG1136	(ABC) transporter
HF896_RS10835	COG0577	efflux transmembrane transporter activity
HF896_RS10845	COG0683	leucine binding
HF896_RS10855	COG0583	DNA-binding transcription factor activity
HF896_RS10860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS10870	COG0583	DNA-binding transcription factor activity
HF896_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS10880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF896_RS10890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF896_RS10895	COG3959	Transketolase, thiamine diphosphate binding domain
HF896_RS10900	COG3958	Transketolase
HF896_RS10905	COG2951	lytic endotransglycosylase activity
HF896_RS10920	COG0714	Associated with various cellular activities
HF896_RS10925	COG0123	including yeast histone deacetylase and acetoin utilization protein
HF896_RS10945	COG1960	acyl-CoA dehydrogenase activity
HF896_RS10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF896_RS10995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HF896_RS11000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HF896_RS11010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF896_RS11010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF896_RS11015	COG0509	glycine decarboxylation via glycine cleavage system
HF896_RS11020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HF896_RS11040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF896_RS11050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF896_RS11055	COG0022	dehydrogenase e1 component
HF896_RS11060	COG0022	dehydrogenase e1 component
HF896_RS11060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF896_RS11065	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF896_RS11090	COG3284	Transcriptional regulator
HF896_RS11100	COG4120	Belongs to the binding-protein-dependent transport system permease family
HF896_RS11120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS11130	COG1960	acyl-CoA dehydrogenase activity
HF896_RS11135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS11140	COG1064	alcohol dehydrogenase
HF896_RS11150	COG1024	Enoyl-CoA hydratase
HF896_RS11155	COG0642	Histidine kinase
HF896_RS11160	COG0745	RESPONSE REGULATOR receiver
HF896_RS11190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HF896_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS11210	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS11250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HF896_RS11265	COG0732	type I restriction modification DNA specificity domain
HF896_RS11270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HF896_RS11305	COG0640	Transcriptional regulator
HF896_RS11320	COG1538	Outer membrane efflux protein
HF896_RS11325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF896_RS11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF896_RS11355	COG0642	Histidine kinase
HF896_RS11370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HF896_RS11380	COG4770	biotin carboxylase activity
HF896_RS11385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS11390	COG1703	isobutyryl-CoA mutase activity
HF896_RS11395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS11395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS11405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS11415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF896_RS11420	COG1802	Transcriptional regulator
HF896_RS11425	COG1022	Amp-dependent synthetase and ligase
HF896_RS11435	COG1309	transcriptional regulator
HF896_RS11460	COG2878	Part of a membrane complex involved in electron transport
HF896_RS11470	COG2171	N-acyltransferase activity
HF896_RS11480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF896_RS11485	COG2890	protein-(glutamine-N5) methyltransferase activity
HF896_RS11490	COG0583	DNA-binding transcription factor activity
HF896_RS11495	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS11500	COG1960	acyl-CoA dehydrogenase activity
HF896_RS11510	COG0488	(ABC) transporter
HF896_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS11520	COG0183	Belongs to the thiolase family
HF896_RS11525	COG3243	poly(R)-hydroxyalkanoic acid synthase
HF896_RS11565	COG1752	Esterase of the alpha-beta hydrolase superfamily
HF896_RS11570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF896_RS11580	COG1196	nuclear chromosome segregation
HF896_RS11590	COG1742	UPF0060 membrane protein
HF896_RS11600	COG2814	Major facilitator Superfamily
HF896_RS11605	COG1113	amino acid transport
HF896_RS11610	COG0791	NLP P60 protein
HF896_RS11625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HF896_RS11685	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS11690	COG2079	MmgE PrpD family protein
HF896_RS11695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS11700	COG0583	DNA-binding transcription factor activity
HF896_RS11725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF896_RS11730	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF896_RS11735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HF896_RS11745	COG4566	intracellular signal transduction
HF896_RS11750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HF896_RS11765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HF896_RS11770	COG0167	dihydroorotate dehydrogenase activity
HF896_RS11790	COG0579	oxidoreductase
HF896_RS11810	COG0633	Ferredoxin
HF896_RS11815	COG0443	Heat shock 70 kDa protein
HF896_RS11830	COG0822	iron-sulfur transferase activity
HF896_RS11835	COG1104	cysteine desulfurase activity
HF896_RS11840	COG1959	2 iron, 2 sulfur cluster binding
HF896_RS11845	COG0556	nucleotide-excision repair
HF896_RS11860	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HF896_RS11865	COG1739	Uncharacterized protein family UPF0029
HF896_RS11870	COG3048	D-serine ammonia-lyase activity
HF896_RS11875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF896_RS11885	COG1595	DNA-templated transcription, initiation
HF896_RS11925	COG2197	response regulator
HF896_RS11930	COG0545	Peptidyl-prolyl cis-trans isomerase
HF896_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS11950	COG0183	Belongs to the thiolase family
HF896_RS11965	COG0589	response to stress
HF896_RS11990	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF896_RS12030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF896_RS12050	COG0583	DNA-binding transcription factor activity
HF896_RS12055	COG0436	Aminotransferase
HF896_RS12070	COG1530	ribonuclease E activity
HF896_RS12075	COG1648	precorrin-2 dehydrogenase activity
HF896_RS12075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HF896_RS12085	COG2010	Cytochrome c
HF896_RS12090	COG3391	amine dehydrogenase activity
HF896_RS12120	COG0424	maF-like protein
HF896_RS12125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HF896_RS12130	COG0799	negative regulation of ribosome biogenesis
HF896_RS12135	COG0408	coproporphyrinogen oxidase activity
HF896_RS12140	COG0151	Belongs to the GarS family
HF896_RS12145	COG0217	transcriptional regulatory protein
HF896_RS12150	COG0433	COG0433 Predicted ATPase
HF896_RS12155	COG0625	glutathione transferase activity
HF896_RS12160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF896_RS12170	COG1346	cytolysis
HF896_RS12190	COG4584	PFAM Integrase catalytic
HF896_RS12195	COG1484	DNA-dependent DNA replication
HF896_RS12205	COG1271	oxidase subunit
HF896_RS12225	COG3328	transposase activity
HF896_RS12260	COG0217	transcriptional regulatory protein
HF896_RS12270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HF896_RS12280	COG0628	permease
HF896_RS12285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HF896_RS12290	COG2925	Exonuclease
HF896_RS12295	COG2951	lytic endotransglycosylase activity
HF896_RS12300	COG1136	(ABC) transporter
HF896_RS12315	COG1309	transcriptional regulator
HF896_RS12330	COG0527	aspartate kinase activity
HF896_RS12335	COG0037	tRNA processing
HF896_RS12350	COG0215	cysteine-tRNA ligase activity
HF896_RS12375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF896_RS12380	COG3228	Belongs to the MtfA family
HF896_RS12385	COG3622	Belongs to the hyi family
HF896_RS12390	COG0235	Class ii aldolase
HF896_RS12395	COG3395	kinase activity
HF896_RS12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HF896_RS12405	COG2084	Dehydrogenase
HF896_RS12410	COG2271	Major facilitator Superfamily
HF896_RS12420	COG2186	Transcriptional regulator
HF896_RS12425	COG0583	DNA-binding transcription factor activity
HF896_RS12435	COG0154	amidase activity
HF896_RS12445	COG1522	sequence-specific DNA binding
HF896_RS12455	COG0400	carboxylic ester hydrolase activity
HF896_RS12460	COG3384	dioxygenase
HF896_RS12475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HF896_RS12485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF896_RS12540	COG0564	pseudouridine synthase activity
HF896_RS12550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HF896_RS12580	COG0251	oxidation-reduction process
HF896_RS12590	COG1289	transmembrane transporter activity
HF896_RS12595	COG2918	glutathione biosynthetic process
HF896_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS12620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HF896_RS12625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF896_RS12630	COG0436	Aminotransferase
HF896_RS12635	COG0824	Thioesterase
HF896_RS12655	COG0477	Major facilitator Superfamily
HF896_RS12660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF896_RS12665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF896_RS12670	COG1845	cytochrome c oxidase, subunit III
HF896_RS12675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HF896_RS12690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HF896_RS12715	COG0463	Glycosyl transferase, family 2
HF896_RS12745	COG3608	succinylglutamate desuccinylase aspartoacylase
HF896_RS12745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF896_RS12760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF896_RS12780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF896_RS12785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS12795	COG1960	acyl-CoA dehydrogenase activity
HF896_RS12800	COG0583	DNA-binding transcription factor activity
HF896_RS12810	COG1049	propionate catabolic process, 2-methylcitrate cycle
HF896_RS12825	COG4106	trans-aconitate 2-methyltransferase activity
HF896_RS12830	COG0039	L-malate dehydrogenase activity
HF896_RS12835	COG2188	Transcriptional regulator
HF896_RS12840	COG2009	succinate dehydrogenase
HF896_RS12845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HF896_RS12850	COG1053	succinate dehydrogenase
HF896_RS12855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HF896_RS12860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HF896_RS12865	COG0372	Belongs to the citrate synthase family
HF896_RS12910	COG1484	DNA-dependent DNA replication
HF896_RS12915	COG4584	PFAM Integrase catalytic
HF896_RS12965	COG0582	viral genome integration into host DNA
HF896_RS12970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HF896_RS12970	COG0519	Catalyzes the synthesis of GMP from XMP
HF896_RS12990	COG2867	negative regulation of translational initiation
HF896_RS12995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HF896_RS13015	COG1024	Enoyl-CoA hydratase
HF896_RS13030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF896_RS13035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HF896_RS13040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF896_RS13045	COG0195	Participates in both transcription termination and antitermination
HF896_RS13050	COG0779	Required for maturation of 30S ribosomal subunits
HF896_RS13055	COG3118	belongs to the thioredoxin family
HF896_RS13060	COG2010	Cytochrome c
HF896_RS13060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HF896_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS13075	COG0557	exoribonuclease II activity
HF896_RS13100	COG0741	lytic transglycosylase activity
HF896_RS13105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HF896_RS13110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF896_RS13115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HF896_RS13140	COG1011	Hydrolase
HF896_RS13145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HF896_RS13185	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS13195	COG0642	Histidine kinase
HF896_RS13200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HF896_RS13220	COG1396	sequence-specific DNA binding
HF896_RS13220	COG3800	Transcriptional regulator
HF896_RS13240	COG2828	Protein conserved in bacteria
HF896_RS13265	COG0583	DNA-binding transcription factor activity
HF896_RS13270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HF896_RS13280	COG0415	Belongs to the DNA photolyase family
HF896_RS13285	COG2814	Major facilitator Superfamily
HF896_RS13300	COG2130	NADP-dependent
HF896_RS13330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF896_RS13345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HF896_RS13350	COG1605	Chorismate mutase
HF896_RS13350	COG0077	Prephenate dehydratase
HF896_RS13355	COG0287	Prephenate dehydrogenase
HF896_RS13360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HF896_RS13370	COG0776	regulation of translation
HF896_RS13380	COG3706	GGDEF domain
HF896_RS13390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HF896_RS13395	COG0517	IMP dehydrogenase activity
HF896_RS13395	COG1125	glycine betaine transport
HF896_RS13400	COG0688	phosphatidylethanolamine metabolic process
HF896_RS13415	COG1959	2 iron, 2 sulfur cluster binding
HF896_RS13450	COG0583	DNA-binding transcription factor activity
HF896_RS13455	COG0473	3-isopropylmalate dehydrogenase activity
HF896_RS13460	COG1752	Esterase of the alpha-beta hydrolase superfamily
HF896_RS13475	COG2721	sulfolactate sulfo-lyase activity
HF896_RS13480	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS13495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HF896_RS13510	COG1228	amidohydrolase
HF896_RS13520	COG1126	abc transporter atp-binding protein
HF896_RS13525	COG0765	amino acid transport
HF896_RS13540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HF896_RS13545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HF896_RS13555	COG2986	histidine ammonia-lyase
HF896_RS13560	COG2188	Transcriptional regulator
HF896_RS13570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HF896_RS13590	COG0583	DNA-binding transcription factor activity
HF896_RS13605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF896_RS13610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS13615	COG0583	DNA-binding transcription factor activity
HF896_RS13625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HF896_RS13635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF896_RS13650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HF896_RS13680	COG0753	catalase activity
HF896_RS13685	COG3634	alkyl hydroperoxide reductase activity
HF896_RS13710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HF896_RS13715	COG0181	hydroxymethylbilane synthase activity
HF896_RS13735	COG3278	Belongs to the heme-copper respiratory oxidase family
HF896_RS13760	COG0525	valine-tRNA ligase activity
HF896_RS13765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HF896_RS13770	COG0425	Belongs to the sulfur carrier protein TusA family
HF896_RS13775	COG2816	NAD+ diphosphatase activity
HF896_RS13785	COG1451	nucleotide metabolic process
HF896_RS13810	COG4584	PFAM Integrase catalytic
HF896_RS13815	COG1484	DNA-dependent DNA replication
HF896_RS13825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS13830	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS13855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS13865	COG1414	Transcriptional regulator
HF896_RS13875	COG1024	Enoyl-CoA hydratase
HF896_RS13880	COG1024	Enoyl-CoA hydratase
HF896_RS13895	COG2030	dehydratase
HF896_RS13900	COG1960	acyl-CoA dehydrogenase activity
HF896_RS13905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS13910	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS13920	COG0427	acetyl-CoA hydrolase
HF896_RS13925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS13940	COG2070	2-Nitropropane dioxygenase
HF896_RS13945	COG1024	Enoyl-CoA hydratase
HF896_RS13970	COG2030	dehydratase
HF896_RS13990	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS13995	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14000	COG1024	Enoyl-CoA hydratase
HF896_RS14010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HF896_RS14010	COG0045	succinate-CoA ligase (ADP-forming) activity
HF896_RS14010	COG1042	CoA-binding domain protein
HF896_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS14020	COG1414	Transcriptional regulator
HF896_RS14035	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14040	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14090	COG1484	DNA-dependent DNA replication
HF896_RS14095	COG4584	PFAM Integrase catalytic
HF896_RS14110	COG0583	DNA-binding transcription factor activity
HF896_RS14125	COG0589	response to stress
HF896_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS14145	COG1309	transcriptional regulator
HF896_RS14155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF896_RS14160	COG1131	(ABC) transporter
HF896_RS14165	COG0842	Transport permease protein
HF896_RS14170	COG0842	Transport permease protein
HF896_RS14180	COG1454	alcohol dehydrogenase
HF896_RS14190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HF896_RS14195	COG1611	Belongs to the LOG family
HF896_RS14215	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HF896_RS14260	COG1477	protein flavinylation
HF896_RS14270	COG3038	cytochrome b561
HF896_RS14275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF896_RS14310	COG1192	Involved in chromosome partitioning
HF896_RS14340	COG1396	sequence-specific DNA binding
HF896_RS14345	COG5489	Protein of unknown function (DUF736)
HF896_RS14355	COG1695	Transcriptional regulator
HF896_RS14365	COG3328	transposase activity
HF896_RS14420	COG0464	growth
HF896_RS14435	COG3657	addiction module killer protein
HF896_RS14450	COG1024	Enoyl-CoA hydratase
HF896_RS14465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF896_RS14475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS14480	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HF896_RS14485	COG1024	Enoyl-CoA hydratase
HF896_RS14495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF896_RS14520	COG0322	excinuclease ABC activity
HF896_RS14560	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14565	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS14590	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS14610	COG1024	Enoyl-CoA hydratase
HF896_RS14615	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS14620	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS14640	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS14645	COG1063	alcohol dehydrogenase
HF896_RS14665	COG0411	ABC transporter
HF896_RS14690	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HF896_RS14705	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14710	COG0583	DNA-binding transcription factor activity
HF896_RS14720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS14735	COG0183	Belongs to the thiolase family
HF896_RS14745	COG2030	dehydratase
HF896_RS14750	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14810	COG1024	Enoyl-CoA hydratase
HF896_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS14820	COG1960	acyl-CoA dehydrogenase activity
HF896_RS14840	COG0183	Belongs to the thiolase family
HF896_RS14855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14895	COG1902	pentaerythritol trinitrate reductase activity
HF896_RS14895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF896_RS14915	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS14930	COG0778	Nitroreductase
HF896_RS14945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS14960	COG2030	dehydratase
HF896_RS14965	COG2301	Belongs to the HpcH HpaI aldolase family
HF896_RS14970	COG1309	transcriptional regulator
HF896_RS14985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF896_RS14990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF896_RS14995	COG0740	serine-type endopeptidase activity
HF896_RS15000	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF896_RS15010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF896_RS15025	COG1562	ergosterol biosynthetic process
HF896_RS15030	COG0840	transmembrane signaling receptor activity
HF896_RS15035	COG1233	COG1233 Phytoene dehydrogenase and related
HF896_RS15045	COG1295	ribonuclease BN
HF896_RS15055	COG0277	FAD linked oxidase domain protein
HF896_RS15060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HF896_RS15075	COG1360	Flagellar Motor Protein
HF896_RS15095	COG0745	RESPONSE REGULATOR receiver
HF896_RS15100	COG2205	protein histidine kinase activity
HF896_RS15110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HF896_RS15115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HF896_RS15125	COG0708	Exodeoxyribonuclease III
HF896_RS15145	COG0174	glutamine synthetase
HF896_RS15175	COG1187	pseudouridine synthase activity
HF896_RS15210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HF896_RS15215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HF896_RS15225	COG0330	HflC and HflK could
HF896_RS15230	COG0330	HflC and HflK could
HF896_RS15235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HF896_RS15240	COG1923	regulation of RNA biosynthetic process
HF896_RS15245	COG1160	GTP binding
HF896_RS15250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF896_RS15260	COG0124	histidyl-tRNA synthetase
HF896_RS15265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF896_RS15280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HF896_RS15285	COG0105	UTP biosynthetic process
HF896_RS15290	COG1187	pseudouridine synthase activity
HF896_RS15295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HF896_RS15300	COG0564	pseudouridine synthase activity
HF896_RS15310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HF896_RS15315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF896_RS15325	COG3540	Alkaline phosphatase
HF896_RS15340	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS15365	COG0179	Fumarylacetoacetate (FAA) hydrolase
HF896_RS15390	COG4191	Histidine kinase
HF896_RS15395	COG0270	DNA (cytosine-5-)-methyltransferase activity
HF896_RS15415	COG2948	multi-organism process
HF896_RS15430	COG3846	protein secretion by the type IV secretion system
HF896_RS15445	COG3451	type IV secretory pathway VirB4
HF896_RS15460	COG4962	Type ii secretion system protein e
HF896_RS15475	COG0583	DNA-binding transcription factor activity
HF896_RS15485	COG0251	oxidation-reduction process
HF896_RS15520	COG4959	Type IV secretory pathway protease TraF
HF896_RS15535	COG1192	Involved in chromosome partitioning
HF896_RS15560	COG1476	TRANSCRIPTIONal
HF896_RS15570	COG5489	Protein of unknown function (DUF736)
HF896_RS15580	COG1475	DNA binding
HF896_RS15620	COG0582	viral genome integration into host DNA
HF896_RS15625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HF896_RS15640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF896_RS15655	COG1968	undecaprenyl-diphosphatase activity
HF896_RS15670	COG2972	Histidine kinase
HF896_RS15675	COG3279	Response regulator of the LytR AlgR family
HF896_RS15680	COG2814	Major facilitator Superfamily
HF896_RS15690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF896_RS15695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HF896_RS15700	COG2916	Histone family protein nucleoid-structuring protein H-NS
HF896_RS15705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HF896_RS15715	COG3245	cytochrome
HF896_RS15725	COG4263	nitrous-oxide reductase activity
HF896_RS15745	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HF896_RS15760	COG0513	Belongs to the DEAD box helicase family
HF896_RS15765	COG2321	neutral zinc metallopeptidase
HF896_RS15770	COG0717	Belongs to the dCTP deaminase family
HF896_RS15795	COG0405	Gamma-glutamyltransferase
HF896_RS15810	COG2084	Dehydrogenase
HF896_RS15815	COG3622	Belongs to the hyi family
HF896_RS15820	COG3960	tartronate-semialdehyde synthase activity
HF896_RS15825	COG0583	DNA-binding transcription factor activity
HF896_RS15835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HF896_RS15860	COG0583	DNA-binding transcription factor activity
HF896_RS15865	COG2186	Transcriptional regulator
HF896_RS15880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF896_RS15895	COG0840	transmembrane signaling receptor activity
HF896_RS15900	COG2233	PERMEase
HF896_RS15905	COG0280	phosphate acetyltransferase
HF896_RS15905	COG0281	malic enzyme
HF896_RS15930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF896_RS15935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HF896_RS15940	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS15950	COG0359	binds to the 23S rRNA
HF896_RS15955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HF896_RS15960	COG2965	DNA replication, synthesis of RNA primer
HF896_RS15965	COG0360	Binds together with S18 to 16S ribosomal RNA
HF896_RS15970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF896_RS15975	COG0443	Heat shock 70 kDa protein
HF896_RS15980	COG0484	heat shock protein binding
HF896_RS15990	COG3033	Beta-eliminating lyase
HF896_RS15995	COG0826	peptidase U32
HF896_RS16000	COG0826	peptidase U32
HF896_RS16005	COG3154	lipid carrier protein
HF896_RS16020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HF896_RS16030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HF896_RS16040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF896_RS16045	COG5510	response to toxic substance
HF896_RS16050	COG0066	3-isopropylmalate dehydratase activity
HF896_RS16055	COG0473	3-isopropylmalate dehydrogenase activity
HF896_RS16070	COG0101	tRNA pseudouridine synthase activity
HF896_RS16075	COG0135	phosphoribosylanthranilate isomerase activity
HF896_RS16080	COG0133	tryptophan synthase activity
HF896_RS16085	COG0159	tryptophan synthase activity
HF896_RS16090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HF896_RS16095	COG0762	integral membrane protein
HF896_RS16115	COG0110	maltose O-acetyltransferase activity
HF896_RS16120	COG0438	transferase activity, transferring glycosyl groups
HF896_RS16135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HF896_RS16140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HF896_RS16145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HF896_RS16185	COG1472	Belongs to the glycosyl hydrolase 3 family
HF896_RS16190	COG0736	holo-[acyl-carrier-protein] synthase activity
HF896_RS16195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HF896_RS16200	COG1381	Involved in DNA repair and RecF pathway recombination
HF896_RS16205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HF896_RS16210	COG0571	ribonuclease III activity
HF896_RS16225	COG0481	GTPase activity
HF896_RS16230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF896_RS16255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF896_RS16260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF896_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS16275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HF896_RS16280	COG0416	fatty acid biosynthetic process
HF896_RS16285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HF896_RS16290	COG1399	metal-binding, possibly nucleic acid-binding protein
HF896_RS16295	COG0424	maF-like protein
HF896_RS16300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HF896_RS16305	COG0616	signal peptide processing
HF896_RS16305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HF896_RS16320	COG0564	pseudouridine synthase activity
HF896_RS16325	COG1530	ribonuclease E activity
HF896_RS16330	COG3022	response to hydroperoxide
HF896_RS16340	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HF896_RS16340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HF896_RS16345	COG0840	transmembrane signaling receptor activity
HF896_RS16350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HF896_RS16355	COG0583	DNA-binding transcription factor activity
HF896_RS16365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS16370	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16380	COG1304	FMN binding
HF896_RS16385	COG2885	chlorophyll binding
HF896_RS16390	COG5001	Diguanylate cyclase
HF896_RS16390	COG3300	MHYT domain
HF896_RS16400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HF896_RS16410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS16425	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16430	COG0252	asparaginase activity
HF896_RS16445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HF896_RS16455	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS16460	COG0165	Argininosuccinate lyase
HF896_RS16465	COG3275	phosphorelay sensor kinase activity
HF896_RS16475	COG2719	SpoVR family
HF896_RS16480	COG2718	Belongs to the UPF0229 family
HF896_RS16485	COG2766	serine protein kinase
HF896_RS16490	COG1959	2 iron, 2 sulfur cluster binding
HF896_RS16495	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HF896_RS16500	COG2346	COG2346, Truncated hemoglobins
HF896_RS16515	COG0667	Aldo Keto reductase
HF896_RS16520	COG2900	Belongs to the SlyX family
HF896_RS16525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF896_RS16535	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS16540	COG0154	amidase activity
HF896_RS16550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HF896_RS16560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HF896_RS16565	COG1492	cobalamin metabolic process
HF896_RS16575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HF896_RS16580	COG4969	Belongs to the N-Me-Phe pilin family
HF896_RS16610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF896_RS16610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF896_RS16615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF896_RS16625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HF896_RS16645	COG0542	response to heat
HF896_RS16650	COG0314	molybdopterin synthase activity
HF896_RS16670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS16680	COG0303	'Molybdopterin
HF896_RS16685	COG1763	Mo-molybdopterin cofactor biosynthetic process
HF896_RS16690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HF896_RS16695	COG1487	ribonuclease activity
HF896_RS16710	COG0436	Aminotransferase
HF896_RS16730	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16735	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16755	COG0183	Belongs to the thiolase family
HF896_RS16765	COG0183	Belongs to the thiolase family
HF896_RS16770	COG1024	Enoyl-CoA hydratase
HF896_RS16775	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16795	COG1024	Enoyl-CoA hydratase
HF896_RS16800	COG1024	Enoyl-CoA hydratase
HF896_RS16800	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS16815	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16820	COG1960	acyl-CoA dehydrogenase activity
HF896_RS16825	COG1024	Enoyl-CoA hydratase
HF896_RS16830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HF896_RS16835	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS16845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS16870	COG1902	pentaerythritol trinitrate reductase activity
HF896_RS16875	COG2226	methyltransferase
HF896_RS16880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HF896_RS16890	COG1120	ATPase activity
HF896_RS16895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HF896_RS16915	COG4206	TonB-dependent receptor
HF896_RS16935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF896_RS16950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF896_RS16985	COG3278	Belongs to the heme-copper respiratory oxidase family
HF896_RS17005	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS17025	COG1802	Transcriptional regulator
HF896_RS17030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HF896_RS17045	COG0129	dihydroxy-acid dehydratase activity
HF896_RS17050	COG0129	dihydroxy-acid dehydratase activity
HF896_RS17065	COG1136	(ABC) transporter
HF896_RS17070	COG4591	ABC-type transport system involved in lipoprotein release permease component
HF896_RS17080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF896_RS17085	COG0840	transmembrane signaling receptor activity
HF896_RS17090	COG0613	PHP domain protein
HF896_RS17095	COG0009	L-threonylcarbamoyladenylate synthase
HF896_RS17105	COG1994	Peptidase M50
HF896_RS17110	COG0180	Tryptophanyl-tRNA synthetase
HF896_RS17115	COG0745	RESPONSE REGULATOR receiver
HF896_RS17130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HF896_RS17145	COG3781	membrane
HF896_RS17150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF896_RS17160	COG1253	flavin adenine dinucleotide binding
HF896_RS17165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HF896_RS17170	COG1047	Peptidyl-prolyl cis-trans
HF896_RS17175	COG2003	Belongs to the UPF0758 family
HF896_RS17185	COG1193	negative regulation of DNA recombination
HF896_RS17195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF896_RS17200	COG0066	3-isopropylmalate dehydratase activity
HF896_RS17210	COG4626	Terminase
HF896_RS17210	COG1802	Transcriptional regulator
HF896_RS17235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HF896_RS17240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HF896_RS17260	COG0437	4 iron, 4 sulfur cluster binding
HF896_RS17265	COG3383	formate dehydrogenase (NAD+) activity
HF896_RS17295	COG3383	formate dehydrogenase (NAD+) activity
HF896_RS17315	COG2186	Transcriptional regulator
HF896_RS17320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS17325	COG1960	acyl-CoA dehydrogenase activity
HF896_RS17335	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS17345	COG0489	protein tyrosine kinase activity
HF896_RS17360	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HF896_RS17375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF896_RS17375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF896_RS17390	COG3135	benzoate transporter
HF896_RS17400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HF896_RS17420	COG0028	Belongs to the TPP enzyme family
HF896_RS17450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HF896_RS17465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HF896_RS17475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HF896_RS17480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HF896_RS17490	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS17515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HF896_RS17520	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HF896_RS17530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF896_RS17535	COG0588	phosphoglycerate mutase activity
HF896_RS17540	COG0793	Belongs to the peptidase S41A family
HF896_RS17545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HF896_RS17555	COG2197	response regulator
HF896_RS17565	COG5487	UPF0391 membrane protein
HF896_RS17575	COG2823	Periplasmic or secreted lipoprotein
HF896_RS17580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF896_RS17585	COG0742	ribosomal rna small subunit methyltransferase
HF896_RS17590	COG0612	Peptidase, M16
HF896_RS17595	COG0612	Peptidase, M16
HF896_RS17605	COG0583	DNA-binding transcription factor activity
HF896_RS17610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF896_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS17625	COG4948	Mandelate Racemase Muconate Lactonizing
HF896_RS17655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HF896_RS17660	COG2706	6-phosphogluconolactonase activity
HF896_RS17685	COG0642	Histidine kinase
HF896_RS17735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF896_RS17740	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS17745	COG1999	signal sequence binding
HF896_RS17750	COG0109	protoheme IX farnesyltransferase activity
HF896_RS17785	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HF896_RS17790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF896_RS17800	COG2226	methyltransferase
HF896_RS17805	COG1040	competence protein
HF896_RS17810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HF896_RS17830	COG1280	lysine exporter protein (LysE YggA)
HF896_RS17835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HF896_RS17835	COG0475	glutathione-regulated potassium exporter activity
HF896_RS17850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF896_RS17855	COG0066	3-isopropylmalate dehydratase activity
HF896_RS17885	COG1473	amidohydrolase
HF896_RS17895	COG0583	DNA-binding transcription factor activity
HF896_RS17915	COG0183	Belongs to the thiolase family
HF896_RS17920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HF896_RS17930	COG1414	Transcriptional regulator
HF896_RS17950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF896_RS17960	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS17965	COG1609	Transcriptional regulator
HF896_RS17970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS18020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF896_RS18025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF896_RS18050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF896_RS18055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HF896_RS18055	COG0543	2 iron, 2 sulfur cluster binding
HF896_RS18065	COG0642	Histidine kinase
HF896_RS18075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF896_RS18085	COG1178	ABC-type Fe3 transport system permease component
HF896_RS18090	COG3842	ATPase activity
HF896_RS18105	COG0540	Belongs to the ATCase OTCase family
HF896_RS18110	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HF896_RS18115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF896_RS18120	COG1678	Uncharacterized ACR, COG1678
HF896_RS18125	COG0643	Histidine kinase
HF896_RS18125	COG0784	Response regulator, receiver
HF896_RS18125	COG2198	Histidine kinase
HF896_RS18130	COG0840	transmembrane signaling receptor activity
HF896_RS18150	COG1773	rubredoxin
HF896_RS18160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HF896_RS18165	COG0138	bifunctional purine biosynthesis protein purh
HF896_RS18170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HF896_RS18175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF896_RS18180	COG1238	metal cluster binding
HF896_RS18190	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS18195	COG1473	amidohydrolase
HF896_RS18210	COG2205	protein histidine kinase activity
HF896_RS18220	COG0012	GTP binding
HF896_RS18225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF896_RS18240	COG1024	Enoyl-CoA hydratase
HF896_RS18255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF896_RS18260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF896_RS18265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HF896_RS18290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF896_RS18290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF896_RS18315	COG2264	protein methyltransferase activity
HF896_RS18320	COG0439	Biotin carboxylase
HF896_RS18325	COG0511	ligase activity, forming carbon-carbon bonds
HF896_RS18330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HF896_RS18340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF896_RS18350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HF896_RS18355	COG0312	modulator of DNA gyrase
HF896_RS18360	COG0772	Belongs to the SEDS family
HF896_RS18365	COG3150	esterase
HF896_RS18375	COG3474	cytochrome
HF896_RS18385	COG1595	DNA-templated transcription, initiation
HF896_RS18390	COG0557	exoribonuclease II activity
HF896_RS18400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HF896_RS18405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HF896_RS18420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HF896_RS18435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HF896_RS18445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HF896_RS18460	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS18495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HF896_RS18500	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF896_RS18505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF896_RS18510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HF896_RS18515	COG0772	Belongs to the SEDS family
HF896_RS18520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HF896_RS18525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HF896_RS18530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HF896_RS18535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HF896_RS18550	COG0275	rRNA processing
HF896_RS18555	COG2001	Belongs to the MraZ family
HF896_RS18560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HF896_RS18565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HF896_RS18580	COG0523	cobalamin synthesis protein
HF896_RS18595	COG2201	protein-glutamate methylesterase activity
HF896_RS18605	COG2202	Pas domain
HF896_RS18605	COG2205	protein histidine kinase activity
HF896_RS18610	COG2201	protein-glutamate methylesterase activity
HF896_RS18615	COG0745	RESPONSE REGULATOR receiver
HF896_RS18620	COG0784	Response regulator, receiver
HF896_RS18620	COG3437	response regulator, receiver
HF896_RS18630	COG5002	protein histidine kinase activity
HF896_RS18630	COG2205	protein histidine kinase activity
HF896_RS18630	COG0784	Response regulator, receiver
HF896_RS18640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HF896_RS18650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HF896_RS18660	COG1187	pseudouridine synthase activity
HF896_RS18685	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HF896_RS18725	COG1846	Transcriptional regulator
HF896_RS18730	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS18735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HF896_RS18745	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS18770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS18780	COG1024	Enoyl-CoA hydratase
HF896_RS18785	COG1960	acyl-CoA dehydrogenase activity
HF896_RS18790	COG1960	acyl-CoA dehydrogenase activity
HF896_RS18795	COG0183	Belongs to the thiolase family
HF896_RS18800	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF896_RS18800	COG1024	Enoyl-CoA hydratase
HF896_RS18805	COG0583	DNA-binding transcription factor activity
HF896_RS18835	COG0501	Belongs to the peptidase M48B family
HF896_RS18845	COG0418	dihydroorotase activity
HF896_RS18855	COG3189	MarR family transcriptional regulator
HF896_RS18860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HF896_RS18865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HF896_RS18870	COG0683	leucine binding
HF896_RS18885	COG0477	Major facilitator Superfamily
HF896_RS18930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HF896_RS18950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS18955	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS18995	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HF896_RS19000	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS19005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF896_RS19015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HF896_RS19020	COG3706	GGDEF domain
HF896_RS19020	COG5001	Diguanylate cyclase
HF896_RS19020	COG4251	negative regulation of phosphorylation
HF896_RS19020	COG2203	Gaf domain
HF896_RS19025	COG0747	negative chemotaxis
HF896_RS19035	COG5001	Diguanylate cyclase
HF896_RS19035	COG5002	protein histidine kinase activity
HF896_RS19040	COG3012	SEC-C Motif Domain Protein
HF896_RS19090	COG1960	acyl-CoA dehydrogenase activity
HF896_RS19100	COG0183	Belongs to the thiolase family
HF896_RS19105	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HF896_RS19110	COG0288	reversible hydration of carbon dioxide
HF896_RS19115	COG1960	acyl-CoA dehydrogenase activity
HF896_RS19120	COG0789	Transcriptional regulator
HF896_RS19155	COG2201	protein-glutamate methylesterase activity
HF896_RS19160	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HF896_RS19165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HF896_RS19175	COG0643	Histidine kinase
HF896_RS19175	COG2198	Histidine kinase
HF896_RS19180	COG2201	protein-glutamate methylesterase activity
HF896_RS19195	COG2197	response regulator
HF896_RS19205	COG1987	bacterial-type flagellum assembly
HF896_RS19210	COG1338	Plays a role in the flagellum-specific transport system
HF896_RS19220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HF896_RS19260	COG1766	The M ring may be actively involved in energy transduction
HF896_RS19265	COG1677	Flagellar hook-basal body complex protein FliE
HF896_RS19295	COG3754	Rhamnan synthesis protein F
HF896_RS19300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS19310	COG1360	Flagellar Motor Protein
HF896_RS19315	COG0745	RESPONSE REGULATOR receiver
HF896_RS19320	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HF896_RS19345	COG1191	sigma factor activity
HF896_RS19360	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HF896_RS19365	COG1815	bacterial-type flagellum-dependent cell motility
HF896_RS19370	COG1558	bacterial-type flagellum-dependent cell motility
HF896_RS19375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HF896_RS19380	COG1749	Flagellar hook protein flgE
HF896_RS19395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HF896_RS19400	COG1706	bacterial-type flagellum-dependent cell motility
HF896_RS19405	COG3951	Flagellar rod assembly protein muramidase FlgJ
HF896_RS19405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HF896_RS19415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HF896_RS19425	COG2070	2-Nitropropane dioxygenase
HF896_RS19430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF896_RS19440	COG0697	spore germination
HF896_RS19445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF896_RS19450	COG0384	phenazine biosynthesis protein PhzF
HF896_RS19455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HF896_RS19480	COG5001	Diguanylate cyclase
HF896_RS19480	COG4251	negative regulation of phosphorylation
HF896_RS19480	COG3706	GGDEF domain
HF896_RS19480	COG2203	Gaf domain
HF896_RS19505	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS19530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HF896_RS19535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HF896_RS19540	COG0183	Belongs to the thiolase family
HF896_RS19545	COG1024	Enoyl-CoA hydratase
HF896_RS19550	COG1022	Amp-dependent synthetase and ligase
HF896_RS19585	COG0679	Auxin Efflux Carrier
HF896_RS19590	COG0210	DNA helicase
HF896_RS19605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HF896_RS19625	COG0179	Fumarylacetoacetate (FAA) hydrolase
HF896_RS19635	COG1802	Transcriptional regulator
HF896_RS19645	COG0589	response to stress
HF896_RS19650	COG0343	queuine tRNA-ribosyltransferase activity
HF896_RS19680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HF896_RS19690	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS19690	COG0204	Acyl-transferase
HF896_RS19695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF896_RS19720	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS19725	COG2072	flavoprotein involved in K transport
HF896_RS19750	COG2365	Tyrosine phosphatase family
HF896_RS19765	COG1414	Transcriptional regulator
HF896_RS19805	COG1960	acyl-CoA dehydrogenase activity
HF896_RS19890	COG0583	DNA-binding transcription factor activity
HF896_RS19910	COG4974	Belongs to the 'phage' integrase family
HF896_RS19915	COG0582	viral genome integration into host DNA
HF896_RS19920	COG4974	Belongs to the 'phage' integrase family
HF896_RS19930	COG0203	ribosomal protein L17
HF896_RS19935	COG0202	RNA polymerase activity
HF896_RS19940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HF896_RS19945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HF896_RS19950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF896_RS19955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HF896_RS19960	COG0201	protein transport
HF896_RS19965	COG0200	Binds to the 23S rRNA
HF896_RS19970	COG1841	ribosomal large subunit assembly
HF896_RS19975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HF896_RS19980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HF896_RS19985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HF896_RS19990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HF896_RS19995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF896_RS20000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HF896_RS20005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HF896_RS20010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF896_RS20015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HF896_RS20025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HF896_RS20040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF896_RS20045	COG0783	Belongs to the Dps family
HF896_RS20055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF896_RS20065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HF896_RS20085	COG0583	DNA-binding transcription factor activity
HF896_RS20090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HF896_RS20095	COG0134	indole-3-glycerol-phosphate synthase activity
HF896_RS20105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HF896_RS20110	COG0512	Glutamine amidotransferase of anthranilate synthase
HF896_RS20160	COG0629	single-stranded DNA binding
HF896_RS20165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF896_RS20170	COG0270	DNA (cytosine-5-)-methyltransferase activity
HF896_RS20280	COG0456	acetyltransferase
HF896_RS20280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HF896_RS20370	COG2003	Belongs to the UPF0758 family
HF896_RS20445	COG1960	acyl-CoA dehydrogenase activity
HF896_RS20470	COG1022	Amp-dependent synthetase and ligase
HF896_RS20485	COG0183	Belongs to the thiolase family
HF896_RS20495	COG1024	Enoyl-CoA hydratase
HF896_RS20520	COG0798	PFAM Bile acid sodium symporter
HF896_RS20545	COG0640	Transcriptional regulator
HF896_RS20595	COG0840	transmembrane signaling receptor activity
HF896_RS20605	COG0546	phosphoglycolate phosphatase activity
HF896_RS20615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF896_RS20620	COG2967	ApaG domain
HF896_RS20635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HF896_RS20645	COG1309	transcriptional regulator
HF896_RS20650	COG3243	poly(R)-hydroxyalkanoic acid synthase
HF896_RS20655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HF896_RS20660	COG1538	Outer membrane efflux protein
HF896_RS20665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF896_RS20670	COG0842	Transport permease protein
HF896_RS20670	COG1129	ABC transporter
HF896_RS20675	COG0842	Transport permease protein
HF896_RS20685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HF896_RS20690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF896_RS20700	COG0840	transmembrane signaling receptor activity
HF896_RS20720	COG3318	Belongs to the UPF0149 family
HF896_RS20720	COG3012	SEC-C Motif Domain Protein
HF896_RS20745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HF896_RS20750	COG1137	ATPase activity
HF896_RS20760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HF896_RS20770	COG0018	arginyl-trna synthetase
HF896_RS20785	COG1301	dicarboxylic acid transport
HF896_RS20790	COG4191	Histidine kinase
HF896_RS20805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HF896_RS20815	COG1942	4-Oxalocrotonate Tautomerase
HF896_RS20825	COG0121	glutamine amidotransferase
HF896_RS20855	COG0189	ligase activity
HF896_RS20860	COG3135	benzoate transporter
HF896_RS20865	COG3158	transport of potassium into the cell
HF896_RS20875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HF896_RS20880	COG0569	domain protein
HF896_RS20885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HF896_RS20910	COG1466	dna polymerase III delta subunit
HF896_RS20920	COG0495	leucyl-tRNA aminoacylation
HF896_RS20925	COG0668	transmembrane transport
HF896_RS20930	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS20940	COG3284	Transcriptional regulator
HF896_RS20950	COG2199	diguanylate cyclase activity
HF896_RS20950	COG2200	EAL domain
HF896_RS20950	COG2202	Pas domain
HF896_RS20965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HF896_RS20970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF896_RS20975	COG0735	belongs to the Fur family
HF896_RS20980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HF896_RS20990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HF896_RS20995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HF896_RS21000	COG3118	belongs to the thioredoxin family
HF896_RS21010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HF896_RS21015	COG0009	L-threonylcarbamoyladenylate synthase
HF896_RS21030	COG3328	transposase activity
HF896_RS21075	COG2027	D-alanyl-D-alanine carboxypeptidase
HF896_RS21095	COG0598	Magnesium transport protein CorA
HF896_RS21115	COG0318	PFAM AMP-dependent synthetase and ligase
HF896_RS21120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HF896_RS21125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HF896_RS21140	COG0469	pyruvate kinase activity
HF896_RS21145	COG0006	proline dipeptidase activity
HF896_RS21150	COG1024	Enoyl-CoA hydratase
HF896_RS21175	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS21180	COG0583	DNA-binding transcription factor activity
HF896_RS21185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HF896_RS21190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HF896_RS21195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HF896_RS21205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HF896_RS21210	COG0583	DNA-binding transcription factor activity
HF896_RS21255	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS21270	COG0583	DNA-binding transcription factor activity
HF896_RS21280	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS21315	COG0045	succinate-CoA ligase (ADP-forming) activity
HF896_RS21315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HF896_RS21315	COG1042	CoA-binding domain protein
HF896_RS21320	COG0625	glutathione transferase activity
HF896_RS21325	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS21335	COG2814	Major facilitator Superfamily
HF896_RS21345	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS21365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS21370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS21370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS21375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS21375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF896_RS21380	COG1024	Enoyl-CoA hydratase
HF896_RS21385	COG1414	Transcriptional regulator
HF896_RS21390	COG0551	DNA topoisomerase type I activity
HF896_RS21390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF896_RS21410	COG0604	alcohol dehydrogenase
HF896_RS21420	COG2030	dehydratase
HF896_RS21430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS21435	COG1846	Transcriptional regulator
HF896_RS21455	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS21460	COG0642	Histidine kinase
HF896_RS21475	COG1178	ABC-type Fe3 transport system permease component
HF896_RS21480	COG3842	ATPase activity
HF896_RS21485	COG1840	ABC-type Fe3 transport system, periplasmic component
HF896_RS21500	COG1012	belongs to the aldehyde dehydrogenase family
HF896_RS21510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS21515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF896_RS21520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS21535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HF896_RS21540	COG2137	regulation of response to DNA damage stimulus
HF896_RS21550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF896_RS21555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF896_RS21560	COG1862	Preprotein translocase
HF896_RS21570	COG1522	sequence-specific DNA binding
HF896_RS21575	COG2814	Major facilitator Superfamily
HF896_RS21580	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HF896_RS21590	COG4566	intracellular signal transduction
HF896_RS21610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HF896_RS21615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF896_RS21625	COG0625	glutathione transferase activity
HF896_RS21650	COG0861	Integral membrane protein TerC family
HF896_RS21660	COG0583	DNA-binding transcription factor activity
HF896_RS21670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS21675	COG1950	PFAM Membrane protein of
HF896_RS21680	COG4783	chaperone-mediated protein folding
HF896_RS21685	COG0315	cyclic pyranopterin monophosphate synthase activity
HF896_RS21705	COG1234	tRNA 3'-trailer cleavage
HF896_RS21710	COG1716	ATPase activity
HF896_RS21720	COG0861	Integral membrane protein TerC family
HF896_RS21725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HF896_RS21730	COG0045	succinate-CoA ligase (ADP-forming) activity
HF896_RS21735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HF896_RS21740	COG0758	DNA mediated transformation
HF896_RS21750	COG0242	peptide deformylase activity
HF896_RS21760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HF896_RS21775	COG0126	phosphoglycerate kinase activity
HF896_RS21790	COG0697	spore germination
HF896_RS21795	COG0284	orotidine-5'-phosphate decarboxylase activity
HF896_RS21825	COG2814	Major facilitator Superfamily
HF896_RS21830	COG0629	single-stranded DNA binding
HF896_RS21840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS21860	COG1028	Short-chain dehydrogenase reductase Sdr
HF896_RS21870	COG1960	acyl-CoA dehydrogenase activity
HF896_RS21875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS21880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HF896_RS21890	COG0482	sulfurtransferase activity
HF896_RS21895	COG0583	DNA-binding transcription factor activity
HF896_RS21900	COG2828	Protein conserved in bacteria
HF896_RS21910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HF896_RS21920	COG1053	succinate dehydrogenase
HF896_RS21920	COG3976	FMN-binding domain protein
HF896_RS21940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF896_RS21955	COG0439	Biotin carboxylase
HF896_RS21960	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HF896_RS21980	COG4771	TonB-dependent receptor
HF896_RS21995	COG3181	Tripartite tricarboxylate transporter family receptor
HF896_RS22000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS22010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF896_RS22015	COG0307	riboflavin synthase, alpha
HF896_RS22020	COG1280	lysine exporter protein (LysE YggA)
HF896_RS22025	COG2205	protein histidine kinase activity
HF896_RS22030	COG0745	RESPONSE REGULATOR receiver
HF896_RS22045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HF896_RS22050	COG3038	cytochrome b561
HF896_RS22070	COG1477	protein flavinylation
HF896_RS22085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HF896_RS22095	COG2070	2-Nitropropane dioxygenase
HF896_RS22105	COG1960	acyl-CoA dehydrogenase activity
HF896_RS22110	COG1414	Transcriptional regulator
HF896_RS22120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS22135	COG1960	acyl-CoA dehydrogenase activity
HF896_RS22150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF896_RS22180	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HF896_RS22225	COG3706	GGDEF domain
HF896_RS22230	COG1802	Transcriptional regulator
HF896_RS22240	COG0559	Belongs to the binding-protein-dependent transport system permease family
HF896_RS22245	COG4177	L-phenylalanine transmembrane transporter activity
HF896_RS22275	COG4290	ribonuclease
HF896_RS22285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF896_RS22290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF896_RS22295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HF896_RS22305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HF896_RS22320	COG1196	nuclear chromosome segregation
HF896_RS22335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF896_RS22340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HF896_RS22345	COG2119	membrane
HF896_RS22350	COG0724	RNA recognition motif
HF896_RS22355	COG0724	RNA recognition motif
HF896_RS22360	COG0300	oxidoreductase activity
HF896_RS22370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HF896_RS22385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HF896_RS22400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF896_RS22405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF896_RS22410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF896_RS22440	COG0601	transmembrane transport
HF896_RS22450	COG4172	Belongs to the ABC transporter superfamily
HF896_RS22455	COG1446	asparaginase
HF896_RS22475	COG0747	negative chemotaxis
HF896_RS22480	COG0706	membrane insertase activity
HF896_RS22485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HF896_RS22490	COG0594	ribonuclease P activity
HF896_RS22495	COG0230	Belongs to the bacterial ribosomal protein bL34 family