locus-tag	class	description
AACI_RS00015	COG0592	DNA-directed DNA polymerase activity
AACI_RS00020	COG2501	S4 domain
AACI_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AACI_RS00030	COG0187	DNA topoisomerase II activity
AACI_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AACI_RS00070	COG0517	IMP dehydrogenase activity
AACI_RS00070	COG0516	GMP reductase activity
AACI_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AACI_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AACI_RS00140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AACI_RS00160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AACI_RS00165	COG2224	Isocitrate lyase
AACI_RS00175	COG1079	Belongs to the binding-protein-dependent transport system permease family
AACI_RS00185	COG3845	ABC transporter
AACI_RS00190	COG1744	ABC transporter substrate-binding protein PnrA-like
AACI_RS00195	COG1335	isochorismatase
AACI_RS00205	COG0824	Thioesterase
AACI_RS00220	COG3842	ATPase activity
AACI_RS00245	COG0745	RESPONSE REGULATOR receiver
AACI_RS00250	COG5002	protein histidine kinase activity
AACI_RS00260	COG1279	arginine transmembrane transporter activity
AACI_RS00275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AACI_RS00280	COG2814	Major facilitator Superfamily
AACI_RS00285	COG0789	Transcriptional regulator
AACI_RS00295	COG1392	Phosphate transport regulator
AACI_RS00300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AACI_RS00305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AACI_RS00315	COG1802	Transcriptional regulator
AACI_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS00345	COG4191	Histidine kinase
AACI_RS00350	COG1215	transferase activity, transferring glycosyl groups
AACI_RS00355	COG0194	GDP metabolic process
AACI_RS00375	COG1435	thymidine kinase activity
AACI_RS00385	COG0644	oxidoreductase
AACI_RS00385	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AACI_RS00390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AACI_RS00395	COG0584	glycerophosphoryl diester phosphodiesterase
AACI_RS00405	COG0395	ABC-type sugar transport system, permease component
AACI_RS00410	COG1175	transmembrane transport
AACI_RS00415	COG2309	aminopeptidase activity
AACI_RS00425	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AACI_RS00430	COG1309	transcriptional regulator
AACI_RS00435	COG1511	domain protein
AACI_RS00440	COG3973	AAA domain
AACI_RS00445	COG0588	phosphoglycerate mutase activity
AACI_RS00450	COG0166	Belongs to the GPI family
AACI_RS00455	COG1940	carbohydrate kinase activity
AACI_RS00500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AACI_RS00510	COG1850	ribulose-bisphosphate carboxylase activity
AACI_RS00515	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AACI_RS00520	COG0235	Class ii aldolase
AACI_RS00525	COG0367	asparagine synthase
AACI_RS00535	COG0590	tRNA wobble adenosine to inosine editing
AACI_RS00545	COG3852	Histidine kinase
AACI_RS00555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AACI_RS00560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AACI_RS00565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AACI_RS00570	COG1970	mechanosensitive ion channel activity
AACI_RS00575	COG1802	Transcriptional regulator
AACI_RS00585	COG3328	transposase activity
AACI_RS00595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AACI_RS00610	COG2244	polysaccharide biosynthetic process
AACI_RS00620	COG1982	Orn Lys Arg decarboxylase major
AACI_RS00625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AACI_RS00630	COG3870	Protein conserved in bacteria
AACI_RS00635	COG0470	DNA polymerase III
AACI_RS00640	COG1774	PSP1 C-terminal conserved region
AACI_RS00645	COG4467	Involved in initiation control of chromosome replication
AACI_RS00655	COG2002	toxin-antitoxin pair type II binding
AACI_RS00665	COG0084	hydrolase, TatD family'
AACI_RS00680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AACI_RS00685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACI_RS00715	COG2197	response regulator
AACI_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS00740	COG1960	acyl-CoA dehydrogenase activity
AACI_RS00745	COG1024	Enoyl-CoA hydratase
AACI_RS00750	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS00770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AACI_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS00785	COG1454	alcohol dehydrogenase
AACI_RS00795	COG1960	acyl-CoA dehydrogenase activity
AACI_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS00810	COG1960	acyl-CoA dehydrogenase activity
AACI_RS00815	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS00820	COG2030	dehydratase
AACI_RS00845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AACI_RS00870	COG4466	Protein conserved in bacteria
AACI_RS00885	COG0189	ligase activity
AACI_RS00885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AACI_RS00890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AACI_RS00895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AACI_RS00900	COG0251	oxidation-reduction process
AACI_RS00905	COG2088	sporulation resulting in formation of a cellular spore
AACI_RS00910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AACI_RS00915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AACI_RS00920	COG0193	aminoacyl-tRNA hydrolase activity
AACI_RS00930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AACI_RS00935	COG2002	toxin-antitoxin pair type II binding
AACI_RS00945	COG3956	TIGRFAM MazG family protein
AACI_RS00955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AACI_RS00975	COG1098	S1 RNA binding domain
AACI_RS00985	COG2131	deaminase
AACI_RS00990	COG2208	phosphoserine phosphatase activity
AACI_RS00995	COG2304	oxidoreductase activity
AACI_RS01005	COG0037	tRNA processing
AACI_RS01015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AACI_RS01035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AACI_RS01040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AACI_RS01045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AACI_RS01050	COG1396	sequence-specific DNA binding
AACI_RS01055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AACI_RS01085	COG2318	DinB family
AACI_RS01090	COG1968	undecaprenyl-diphosphatase activity
AACI_RS01095	COG2223	nitrite transmembrane transporter activity
AACI_RS01100	COG0697	spore germination
AACI_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS01115	COG0436	Aminotransferase
AACI_RS01120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AACI_RS01135	COG3711	transcriptional antiterminator
AACI_RS01145	COG0246	Mannitol dehydrogenase
AACI_RS01150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AACI_RS01155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AACI_RS01160	COG1595	DNA-templated transcription, initiation
AACI_RS01185	COG3845	ABC transporter
AACI_RS01195	COG1268	BioY protein
AACI_RS01215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACI_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS01245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AACI_RS01260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AACI_RS01270	COG0745	RESPONSE REGULATOR receiver
AACI_RS01275	COG2205	protein histidine kinase activity
AACI_RS01280	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AACI_RS01285	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AACI_RS01290	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AACI_RS01295	COG2205	protein histidine kinase activity
AACI_RS01305	COG0667	Aldo Keto reductase
AACI_RS01310	COG2814	Major facilitator Superfamily
AACI_RS01315	COG1388	LysM domain
AACI_RS01315	COG3858	chitin binding
AACI_RS01320	COG4213	ABC transporter substrate-binding protein
AACI_RS01330	COG4214	carbohydrate transport
AACI_RS01345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACI_RS01350	COG0386	Belongs to the glutathione peroxidase family
AACI_RS01455	COG1739	Uncharacterized protein family UPF0029
AACI_RS01475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AACI_RS01515	COG3328	transposase activity
AACI_RS01530	COG0420	3'-5' exonuclease activity
AACI_RS01535	COG0419	ATPase involved in DNA repair
AACI_RS01545	COG2217	Heavy metal translocating P-type atpase
AACI_RS01550	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS01560	COG1595	DNA-templated transcription, initiation
AACI_RS01575	COG0805	protein transport
AACI_RS01580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AACI_RS01585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AACI_RS01610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AACI_RS01625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AACI_RS01630	COG1459	type II secretion system
AACI_RS01680	COG1111	helicase
AACI_RS01680	COG1205	dead DEAH box helicase
AACI_RS01690	COG3829	transcription factor binding
AACI_RS01695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AACI_RS01730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AACI_RS01735	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS01740	COG3829	transcription factor binding
AACI_RS01745	COG0833	amino acid
AACI_RS01770	COG5263	repeat protein
AACI_RS01770	COG4193	domain, Protein
AACI_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS01780	COG1472	Belongs to the glycosyl hydrolase 3 family
AACI_RS01790	COG2814	Major facilitator Superfamily
AACI_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS01820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AACI_RS01825	COG0753	catalase activity
AACI_RS01830	COG1033	growth of symbiont in host cell
AACI_RS01830	COG2409	Drug exporters of the RND superfamily
AACI_RS01835	COG4846	Membrane protein involved in cytochrome C biogenesis
AACI_RS01845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AACI_RS01860	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AACI_RS01865	COG0024	Methionine aminopeptidase
AACI_RS01880	COG0736	holo-[acyl-carrier-protein] synthase activity
AACI_RS01885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AACI_RS01885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AACI_RS01890	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AACI_RS01895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AACI_RS01905	COG2337	Toxic component of a toxin-antitoxin (TA) module
AACI_RS01910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AACI_RS01915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AACI_RS01920	COG3437	response regulator, receiver
AACI_RS01920	COG2770	Histidine kinase
AACI_RS01935	COG4844	belongs to the
AACI_RS01945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AACI_RS01950	COG0802	atpase or kinase
AACI_RS01960	COG0456	acetyltransferase
AACI_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AACI_RS01970	COG0488	(ABC) transporter
AACI_RS01975	COG0671	phosphoesterase, PA-phosphatase related
AACI_RS01980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AACI_RS01990	COG1546	Belongs to the CinA family
AACI_RS01990	COG1058	Belongs to the CinA family
AACI_RS01995	COG1763	Mo-molybdopterin cofactor biosynthetic process
AACI_RS02000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AACI_RS02030	COG2197	response regulator
AACI_RS02040	COG0714	Associated with various cellular activities
AACI_RS02050	COG1305	Transglutaminase-like
AACI_RS02055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AACI_RS02065	COG0519	Catalyzes the synthesis of GMP from XMP
AACI_RS02065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AACI_RS02070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AACI_RS02075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AACI_RS02080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AACI_RS02090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AACI_RS02095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AACI_RS02100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AACI_RS02105	COG0138	bifunctional purine biosynthesis protein purh
AACI_RS02110	COG0151	Belongs to the GarS family
AACI_RS02135	COG4166	transmembrane transport
AACI_RS02140	COG4948	Mandelate Racemase Muconate Lactonizing
AACI_RS02145	COG2884	Cell division ATP-binding protein ftsE
AACI_RS02150	COG2177	Part of the ABC transporter FtsEX involved in
AACI_RS02155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AACI_RS02160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AACI_RS02170	COG0556	nucleotide-excision repair
AACI_RS02175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AACI_RS02180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AACI_RS02190	COG4235	cytochrome complex assembly
AACI_RS02200	COG1660	Displays ATPase and GTPase activities
AACI_RS02205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AACI_RS02210	COG1481	regulation of sporulation
AACI_RS02215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AACI_RS02240	COG0670	Belongs to the BI1 family
AACI_RS02245	COG0495	leucyl-tRNA aminoacylation
AACI_RS02265	COG0628	permease
AACI_RS02280	COG1111	helicase
AACI_RS02280	COG1205	dead DEAH box helicase
AACI_RS02295	COG0737	Belongs to the 5'-nucleotidase family
AACI_RS02300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AACI_RS02310	COG0697	spore germination
AACI_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS02340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AACI_RS02345	COG0328	RNA-DNA hybrid ribonuclease activity
AACI_RS02350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AACI_RS02355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AACI_RS02365	COG0538	isocitrate dehydrogenase activity
AACI_RS02370	COG1414	Transcriptional regulator
AACI_RS02380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AACI_RS02410	COG2272	Belongs to the type-B carboxylesterase lipase family
AACI_RS02415	COG2766	serine protein kinase
AACI_RS02420	COG2718	Belongs to the UPF0229 family
AACI_RS02425	COG2719	SpoVR family
AACI_RS02430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AACI_RS02435	COG1396	sequence-specific DNA binding
AACI_RS02505	COG0592	DNA-directed DNA polymerase activity
AACI_RS02570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AACI_RS02615	COG3328	transposase activity
AACI_RS02630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AACI_RS02650	COG5002	protein histidine kinase activity
AACI_RS02655	COG2197	response regulator
AACI_RS02690	COG0784	Response regulator, receiver
AACI_RS02690	COG3437	response regulator, receiver
AACI_RS02700	COG0589	response to stress
AACI_RS02735	COG0346	lactoylglutathione lyase activity
AACI_RS02740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AACI_RS02745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AACI_RS02750	COG1247	-acetyltransferase
AACI_RS02755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AACI_RS02930	COG2894	cell division
AACI_RS02940	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AACI_RS03055	COG4456	Virulence-associated protein
AACI_RS03135	COG2002	toxin-antitoxin pair type II binding
AACI_RS03145	COG0583	DNA-binding transcription factor activity
AACI_RS03170	COG2719	SpoVR family
AACI_RS03210	COG2860	membrane
AACI_RS03220	COG2200	EAL domain
AACI_RS03220	COG2199	diguanylate cyclase activity
AACI_RS03230	COG0529	Catalyzes the synthesis of activated sulfate
AACI_RS03245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AACI_RS03250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AACI_RS03260	COG1131	(ABC) transporter
AACI_RS03270	COG1131	(ABC) transporter
AACI_RS03275	COG1725	Transcriptional regulator
AACI_RS03280	COG1234	tRNA 3'-trailer cleavage
AACI_RS03285	COG2814	Major facilitator Superfamily
AACI_RS03290	COG1846	Transcriptional regulator
AACI_RS03305	COG1131	(ABC) transporter
AACI_RS03310	COG0842	Transport permease protein
AACI_RS03315	COG4585	Histidine kinase
AACI_RS03320	COG2197	response regulator
AACI_RS03345	COG1845	cytochrome c oxidase, subunit III
AACI_RS03350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AACI_RS03355	COG1612	heme a metabolic process
AACI_RS03360	COG1686	Belongs to the peptidase S11 family
AACI_RS03380	COG0667	Aldo Keto reductase
AACI_RS03385	COG1454	alcohol dehydrogenase
AACI_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS03425	COG3850	Histidine kinase
AACI_RS03425	COG5002	protein histidine kinase activity
AACI_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS03445	COG3384	dioxygenase
AACI_RS03450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AACI_RS03455	COG0210	DNA helicase
AACI_RS03460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AACI_RS03470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AACI_RS03475	COG0154	amidase activity
AACI_RS03480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AACI_RS03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AACI_RS03490	COG1073	alpha beta
AACI_RS03520	COG1716	ATPase activity
AACI_RS03520	COG1131	(ABC) transporter
AACI_RS03520	COG0842	Transport permease protein
AACI_RS03545	COG1070	Carbohydrate kinase
AACI_RS03550	COG3347	Dehydrogenase
AACI_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS03555	COG4952	isomerase
AACI_RS03560	COG1129	ABC transporter
AACI_RS03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
AACI_RS03580	COG1349	DNA-binding transcription factor activity
AACI_RS03595	COG1139	Iron-sulfur cluster binding protein
AACI_RS03600	COG0247	lactate metabolic process
AACI_RS03610	COG2323	membrane
AACI_RS03620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AACI_RS03630	COG2755	lipolytic protein G-D-S-L family
AACI_RS03630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AACI_RS03635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AACI_RS03655	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS03665	COG2271	Major facilitator Superfamily
AACI_RS03670	COG2155	Conserved Protein
AACI_RS03675	COG0019	diaminopimelate decarboxylase activity
AACI_RS03690	COG1914	H( )-stimulated, divalent metal cation uptake system
AACI_RS03705	COG1164	Oligoendopeptidase f
AACI_RS03710	COG5002	protein histidine kinase activity
AACI_RS03715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AACI_RS03720	COG0126	phosphoglycerate kinase activity
AACI_RS03725	COG0149	triose-phosphate isomerase activity
AACI_RS03735	COG0148	phosphopyruvate hydratase activity
AACI_RS03740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AACI_RS03745	COG2807	transmembrane transport
AACI_RS03750	COG0557	exoribonuclease II activity
AACI_RS03755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AACI_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS03765	COG5609	conserved protein (DUF2294)
AACI_RS03770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AACI_RS03775	COG3002	Belongs to the UPF0753 family
AACI_RS03805	COG2226	methyltransferase
AACI_RS03820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AACI_RS03825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AACI_RS03840	COG3665	Urea carboxylase-associated protein
AACI_RS03845	COG0439	Biotin carboxylase
AACI_RS03855	COG0395	ABC-type sugar transport system, permease component
AACI_RS03860	COG1175	transmembrane transport
AACI_RS03895	COG0681	Belongs to the peptidase S26 family
AACI_RS03900	COG0667	Aldo Keto reductase
AACI_RS03905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AACI_RS03930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AACI_RS03940	COG0673	inositol 2-dehydrogenase activity
AACI_RS03960	COG3459	Glycosyltransferase 36 associated
AACI_RS03965	COG2814	Major facilitator Superfamily
AACI_RS03970	COG1609	Transcriptional regulator
AACI_RS03975	COG0395	ABC-type sugar transport system, permease component
AACI_RS03985	COG1175	transmembrane transport
AACI_RS03990	COG1486	melibiose metabolic process
AACI_RS04000	COG2079	MmgE PrpD family protein
AACI_RS04005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AACI_RS04010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AACI_RS04025	COG0542	response to heat
AACI_RS04035	COG1309	transcriptional regulator
AACI_RS04040	COG3396	Phenylacetate-CoA oxygenase
AACI_RS04055	COG2151	metal-sulfur cluster biosynthetic enzyme
AACI_RS04060	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AACI_RS04075	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS04080	COG1024	Enoyl-CoA hydratase
AACI_RS04100	COG1346	cytolysis
AACI_RS04105	COG1380	Effector of murein hydrolase LrgA
AACI_RS04110	COG0583	DNA-binding transcription factor activity
AACI_RS04120	COG2808	Putative FMN-binding domain
AACI_RS04125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AACI_RS04150	COG2962	Rard protein
AACI_RS04165	COG1132	(ABC) transporter
AACI_RS04170	COG1132	(ABC) transporter
AACI_RS04175	COG0604	alcohol dehydrogenase
AACI_RS04190	COG1132	(ABC) transporter
AACI_RS04205	COG5609	conserved protein (DUF2294)
AACI_RS04210	COG2116	formate transmembrane transporter activity
AACI_RS04215	COG3383	formate dehydrogenase (NAD+) activity
AACI_RS04225	COG1252	NADH dehydrogenase
AACI_RS04235	COG0656	L-ascorbic acid biosynthetic process
AACI_RS04240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACI_RS04245	COG2814	Major facilitator Superfamily
AACI_RS04265	COG0561	phosphatase activity
AACI_RS04285	COG0519	Catalyzes the synthesis of GMP from XMP
AACI_RS04295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AACI_RS04300	COG1119	ATPase activity
AACI_RS04305	COG2353	YceI-like domain
AACI_RS04310	COG1733	regulation of RNA biosynthetic process
AACI_RS04320	COG2046	Belongs to the sulfate adenylyltransferase family
AACI_RS04325	COG1846	Transcriptional regulator
AACI_RS04335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACI_RS04340	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS04345	COG0667	Aldo Keto reductase
AACI_RS04350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AACI_RS04355	COG1335	isochorismatase
AACI_RS04370	COG2814	Major facilitator Superfamily
AACI_RS04375	COG3973	AAA domain
AACI_RS04380	COG2207	Transcriptional regulator
AACI_RS04385	COG0477	Major facilitator Superfamily
AACI_RS04400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AACI_RS04410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AACI_RS04420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AACI_RS04440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AACI_RS04445	COG1349	DNA-binding transcription factor activity
AACI_RS04450	COG1105	Belongs to the carbohydrate kinase PfkB family
AACI_RS04465	COG0154	amidase activity
AACI_RS04470	COG2363	Small membrane protein
AACI_RS04485	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AACI_RS04495	COG0626	cystathionine gamma-synthase activity
AACI_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS04525	COG0424	maF-like protein
AACI_RS04535	COG2081	HI0933 family
AACI_RS04545	COG1979	alcohol dehydrogenase
AACI_RS04570	COG1175	transmembrane transport
AACI_RS04575	COG0395	ABC-type sugar transport system, permease component
AACI_RS04580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AACI_RS04585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AACI_RS04590	COG0109	protoheme IX farnesyltransferase activity
AACI_RS04605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AACI_RS04610	COG2823	Periplasmic or secreted lipoprotein
AACI_RS04610	COG1652	LysM domain
AACI_RS04615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AACI_RS04620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AACI_RS04625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AACI_RS04630	COG0131	Imidazoleglycerol-phosphate dehydratase
AACI_RS04635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AACI_RS04640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AACI_RS04645	COG0107	imidazoleglycerol-phosphate synthase activity
AACI_RS04650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AACI_RS04650	COG0140	phosphoribosyl-ATP diphosphatase activity
AACI_RS04665	COG0604	alcohol dehydrogenase
AACI_RS04675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACI_RS04675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AACI_RS04685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AACI_RS04685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AACI_RS04690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AACI_RS04695	COG1278	Cold shock
AACI_RS04715	COG4721	ABC-type cobalt transport system, permease component
AACI_RS04720	COG1122	ATPase activity
AACI_RS04730	COG0583	DNA-binding transcription factor activity
AACI_RS04735	COG0482	sulfurtransferase activity
AACI_RS04770	COG1960	acyl-CoA dehydrogenase activity
AACI_RS04780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AACI_RS04810	COG0564	pseudouridine synthase activity
AACI_RS04815	COG1295	ribonuclease BN
AACI_RS04820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AACI_RS04835	COG1160	GTP binding
AACI_RS04840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AACI_RS04845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AACI_RS04855	COG0586	Pfam SNARE associated Golgi protein
AACI_RS04875	COG0302	gtp cyclohydrolase
AACI_RS04895	COG0167	dihydroorotate dehydrogenase activity
AACI_RS04910	COG0686	Belongs to the AlaDH PNT family
AACI_RS04915	COG2151	metal-sulfur cluster biosynthetic enzyme
AACI_RS04920	COG0396	ATPase activity
AACI_RS04925	COG0719	Fe-S assembly protein
AACI_RS04930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AACI_RS04935	COG0822	iron-sulfur transferase activity
AACI_RS04940	COG0719	Fe-S assembly protein
AACI_RS04950	COG1959	2 iron, 2 sulfur cluster binding
AACI_RS04970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AACI_RS04975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AACI_RS04985	COG0531	amino acid
AACI_RS05010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AACI_RS05030	COG0587	DNA-directed DNA polymerase activity
AACI_RS05040	COG0671	phosphoesterase, PA-phosphatase related
AACI_RS05055	COG0537	adenosine 5'-monophosphoramidase activity
AACI_RS05060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AACI_RS05070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AACI_RS05080	COG0612	Peptidase, M16
AACI_RS05085	COG0612	Peptidase, M16
AACI_RS05095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AACI_RS05100	COG0083	homoserine kinase activity
AACI_RS05105	COG2050	protein possibly involved in aromatic compounds catabolism
AACI_RS05140	COG0772	Belongs to the SEDS family
AACI_RS05150	COG0584	glycerophosphoryl diester phosphodiesterase
AACI_RS05155	COG0772	Belongs to the SEDS family
AACI_RS05160	COG0436	Aminotransferase
AACI_RS05180	COG1982	Orn Lys Arg decarboxylase major
AACI_RS05185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AACI_RS05190	COG0316	Belongs to the HesB IscA family
AACI_RS05195	COG1078	dGTPase activity
AACI_RS05200	COG0586	Pfam SNARE associated Golgi protein
AACI_RS05205	COG3377	Domain of unknown function (DUF1805)
AACI_RS05210	COG1363	Peptidase, m42
AACI_RS05215	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AACI_RS05220	COG0494	nUDIX hydrolase
AACI_RS05230	COG1388	LysM domain
AACI_RS05230	COG3584	3D domain protein
AACI_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS05300	COG2070	2-Nitropropane dioxygenase
AACI_RS05305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AACI_RS05430	COG0592	DNA-directed DNA polymerase activity
AACI_RS05475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AACI_RS05480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AACI_RS05490	COG0038	chloride channel
AACI_RS05495	COG5002	protein histidine kinase activity
AACI_RS05500	COG0745	RESPONSE REGULATOR receiver
AACI_RS05505	COG2132	Multicopper oxidase
AACI_RS05525	COG0785	Cytochrome C biogenesis protein
AACI_RS05535	COG2132	Multicopper oxidase
AACI_RS05540	COG1937	Protein conserved in bacteria
AACI_RS05545	COG2217	Heavy metal translocating P-type atpase
AACI_RS05550	COG2217	Heavy metal translocating P-type atpase
AACI_RS05580	COG0346	lactoylglutathione lyase activity
AACI_RS05595	COG0640	Transcriptional regulator
AACI_RS05600	COG2433	Pfam Transposase IS66
AACI_RS05655	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AACI_RS05665	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AACI_RS05860	COG2020	methyltransferase activity
AACI_RS05885	COG0776	regulation of translation
AACI_RS05915	COG2894	cell division
AACI_RS05960	COG2002	toxin-antitoxin pair type II binding
AACI_RS05980	COG1960	acyl-CoA dehydrogenase activity
AACI_RS05985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AACI_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS06000	COG1609	Transcriptional regulator
AACI_RS06015	COG0395	ABC-type sugar transport system, permease component
AACI_RS06020	COG3250	beta-galactosidase activity
AACI_RS06025	COG0512	Glutamine amidotransferase of anthranilate synthase
AACI_RS06045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AACI_RS06050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AACI_RS06055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AACI_RS06065	COG0067	glutamate synthase
AACI_RS06065	COG0069	glutamate synthase activity
AACI_RS06065	COG0070	glutamate synthase
AACI_RS06070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AACI_RS06075	COG0137	argininosuccinate synthase activity
AACI_RS06080	COG0165	Argininosuccinate lyase
AACI_RS06090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AACI_RS06095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AACI_RS06120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AACI_RS06160	COG1725	Transcriptional regulator
AACI_RS06165	COG1131	(ABC) transporter
AACI_RS06175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACI_RS06195	COG1250	3-hydroxyacyl-CoA dehydrogenase
AACI_RS06195	COG1024	Enoyl-CoA hydratase
AACI_RS06200	COG0655	NAD(P)H dehydrogenase (quinone) activity
AACI_RS06205	COG1802	Transcriptional regulator
AACI_RS06210	COG1584	GPR1 FUN34 yaaH family protein
AACI_RS06215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AACI_RS06220	COG3906	Belongs to the UPF0473 family
AACI_RS06245	COG0740	serine-type endopeptidase activity
AACI_RS06250	COG1104	cysteine desulfurase activity
AACI_RS06255	COG0301	tRNA thio-modification
AACI_RS06275	COG0300	oxidoreductase activity
AACI_RS06280	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AACI_RS06285	COG2001	Belongs to the MraZ family
AACI_RS06290	COG0275	rRNA processing
AACI_RS06300	COG0768	penicillin binding
AACI_RS06305	COG0768	penicillin binding
AACI_RS06310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AACI_RS06315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AACI_RS06320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AACI_RS06325	COG0772	Belongs to the SEDS family
AACI_RS06330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AACI_RS06335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AACI_RS06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AACI_RS06345	COG0492	ferredoxin-NADP+ reductase activity
AACI_RS06350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AACI_RS06355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AACI_RS06375	COG3856	small basic protein
AACI_RS06380	COG0849	cell division
AACI_RS06385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AACI_RS06395	COG1191	sigma factor activity
AACI_RS06400	COG1191	sigma factor activity
AACI_RS06405	COG1873	PFAM PRC-barrel domain
AACI_RS06410	COG1496	oxidoreductase activity
AACI_RS06415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AACI_RS06430	COG3599	regulation of cell shape
AACI_RS06445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AACI_RS06450	COG1809	phosphosulfolactate synthase activity
AACI_RS06455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AACI_RS06460	COG0564	pseudouridine synthase activity
AACI_RS06465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AACI_RS06470	COG0540	Belongs to the ATCase OTCase family
AACI_RS06475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AACI_RS06490	COG0284	orotidine-5'-phosphate decarboxylase activity
AACI_RS06500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AACI_RS06500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AACI_RS06510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AACI_RS06515	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AACI_RS06520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AACI_RS06525	COG1561	YicC-like family, N-terminal region
AACI_RS06535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AACI_RS06540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AACI_RS06545	COG0242	peptide deformylase activity
AACI_RS06550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AACI_RS06555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AACI_RS06555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AACI_RS06560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AACI_RS06565	COG0631	protein serine/threonine phosphatase activity
AACI_RS06570	COG0515	serine threonine protein kinase
AACI_RS06570	COG2815	serine threonine protein kinase
AACI_RS06575	COG1162	GTPase activity
AACI_RS06580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AACI_RS06590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AACI_RS06595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AACI_RS06605	COG0688	phosphatidylethanolamine metabolic process
AACI_RS06620	COG0154	amidase activity
AACI_RS06625	COG0742	ribosomal rna small subunit methyltransferase
AACI_RS06630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AACI_RS06635	COG1752	Esterase of the alpha-beta hydrolase superfamily
AACI_RS06650	COG0416	fatty acid biosynthetic process
AACI_RS06655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AACI_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS06665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AACI_RS06670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AACI_RS06675	COG0571	ribonuclease III activity
AACI_RS06680	COG1196	nuclear chromosome segregation
AACI_RS06685	COG0552	protein localization to endoplasmic reticulum
AACI_RS06690	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AACI_RS06695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AACI_RS06700	COG0228	four-way junction DNA binding
AACI_RS06705	COG1837	Belongs to the UPF0109 family
AACI_RS06720	COG0336	Belongs to the RNA methyltransferase TrmD family
AACI_RS06745	COG0564	pseudouridine synthase activity
AACI_RS06755	COG0739	heme binding
AACI_RS06760	COG1607	acyl-coa hydrolase
AACI_RS06780	COG0335	large ribosomal subunit rRNA binding
AACI_RS06790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AACI_RS06820	COG0045	succinate-CoA ligase (ADP-forming) activity
AACI_RS06825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AACI_RS06830	COG0758	DNA mediated transformation
AACI_RS06830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AACI_RS06850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AACI_RS06855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AACI_RS06860	COG4974	Belongs to the 'phage' integrase family
AACI_RS06865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AACI_RS06870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AACI_RS06885	COG1677	Flagellar hook-basal body complex protein FliE
AACI_RS06890	COG1766	The M ring may be actively involved in energy transduction
AACI_RS06895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AACI_RS06905	COG1157	protein secretion by the type III secretion system
AACI_RS06925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AACI_RS06935	COG1749	Flagellar hook protein flgE
AACI_RS06935	COG1749	Flagellar hook protein flgE
AACI_RS06950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AACI_RS06955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AACI_RS06955	COG1776	CheC inhibitor of MCP methylation
AACI_RS06960	COG2201	protein-glutamate methylesterase activity
AACI_RS06965	COG3190	flagellar
AACI_RS06970	COG1338	Plays a role in the flagellum-specific transport system
AACI_RS06975	COG1987	bacterial-type flagellum assembly
AACI_RS06985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AACI_RS06990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AACI_RS06995	COG1419	protein localization to endoplasmic reticulum
AACI_RS07005	COG2201	protein-glutamate methylesterase activity
AACI_RS07010	COG0643	Histidine kinase
AACI_RS07010	COG2198	Histidine kinase
AACI_RS07015	COG0835	chemotaxis
AACI_RS07020	COG1776	CheC inhibitor of MCP methylation
AACI_RS07025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AACI_RS07035	COG0052	Belongs to the universal ribosomal protein uS2 family
AACI_RS07040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AACI_RS07045	COG0528	UMP kinase activity
AACI_RS07050	COG0233	cytoplasmic translational termination
AACI_RS07055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AACI_RS07060	COG4589	Belongs to the CDS family
AACI_RS07065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AACI_RS07070	COG0750	zinc metalloprotease
AACI_RS07075	COG2176	DNA-directed DNA polymerase activity
AACI_RS07080	COG0346	lactoylglutathione lyase activity
AACI_RS07090	COG1217	gtp-binding protein TYPA
AACI_RS07095	COG0779	Required for maturation of 30S ribosomal subunits
AACI_RS07100	COG0195	Participates in both transcription termination and antitermination
AACI_RS07105	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AACI_RS07115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AACI_RS07120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AACI_RS07125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AACI_RS07130	COG0196	riboflavin kinase activity
AACI_RS07140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AACI_RS07145	COG1185	polyribonucleotide nucleotidyltransferase activity
AACI_RS07155	COG0612	Peptidase, M16
AACI_RS07165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AACI_RS07170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AACI_RS07175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AACI_RS07180	COG0527	aspartate kinase activity
AACI_RS07195	COG1960	acyl-CoA dehydrogenase activity
AACI_RS07205	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS07210	COG1024	Enoyl-CoA hydratase
AACI_RS07215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AACI_RS07235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AACI_RS07240	COG0740	serine-type endopeptidase activity
AACI_RS07275	COG1426	Protein conserved in bacteria
AACI_RS07280	COG1666	GTP binding
AACI_RS07285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AACI_RS07290	COG1058	Belongs to the CinA family
AACI_RS07290	COG1546	Belongs to the CinA family
AACI_RS07295	COG0513	Belongs to the DEAD box helicase family
AACI_RS07300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AACI_RS07310	COG1418	mRNA catabolic process
AACI_RS07315	COG2359	stage V sporulation protein S
AACI_RS07345	COG0189	ligase activity
AACI_RS07355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AACI_RS07365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AACI_RS07370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AACI_RS07375	COG2521	methyltransferase
AACI_RS07375	COG2136	Putative SAM-dependent methyltransferase
AACI_RS07380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AACI_RS07385	COG1923	regulation of RNA biosynthetic process
AACI_RS07450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AACI_RS07490	COG3328	transposase activity
AACI_RS07500	COG3328	transposase activity
AACI_RS07505	COG3328	transposase activity
AACI_RS07555	COG3328	transposase activity
AACI_RS07580	COG3328	transposase activity
AACI_RS07625	COG3328	transposase activity
AACI_RS07640	COG3328	transposase activity
AACI_RS07660	COG0473	3-isopropylmalate dehydrogenase activity
AACI_RS07665	COG0697	spore germination
AACI_RS07685	COG0697	spore germination
AACI_RS07690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AACI_RS07695	COG2244	polysaccharide biosynthetic process
AACI_RS07705	COG0464	growth
AACI_RS07725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AACI_RS07730	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AACI_RS07735	COG0789	Transcriptional regulator
AACI_RS07740	COG0174	glutamine synthetase
AACI_RS07745	COG1609	Transcriptional regulator
AACI_RS07750	COG2721	sulfolactate sulfo-lyase activity
AACI_RS07755	COG3718	enzyme involved in inositol metabolism
AACI_RS07760	COG0246	Mannitol dehydrogenase
AACI_RS07765	COG2814	Major facilitator Superfamily
AACI_RS07770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AACI_RS07775	COG0561	phosphatase activity
AACI_RS07780	COG0423	glycine-tRNA ligase activity
AACI_RS07790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AACI_RS07790	COG0646	methionine synthase
AACI_RS07800	COG3706	GGDEF domain
AACI_RS07825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AACI_RS07830	COG2086	electron transfer activity
AACI_RS07835	COG1309	transcriptional regulator
AACI_RS07840	COG2181	nitrate reductase activity
AACI_RS07840	COG0247	lactate metabolic process
AACI_RS07845	COG1250	3-hydroxyacyl-CoA dehydrogenase
AACI_RS07845	COG1024	Enoyl-CoA hydratase
AACI_RS07850	COG0183	Belongs to the thiolase family
AACI_RS07855	COG1960	acyl-CoA dehydrogenase activity
AACI_RS07860	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS07870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACI_RS07875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AACI_RS07880	COG0531	amino acid
AACI_RS07885	COG1289	transmembrane transporter activity
AACI_RS07905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AACI_RS07910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AACI_RS07910	COG0517	IMP dehydrogenase activity
AACI_RS07915	COG0574	Belongs to the PEP-utilizing enzyme family
AACI_RS07915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AACI_RS07920	COG1494	fructose-1,6-bisphosphatase
AACI_RS07935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AACI_RS07960	COG1942	4-Oxalocrotonate Tautomerase
AACI_RS07970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACI_RS07980	COG3971	2-oxopent-4-enoate hydratase activity
AACI_RS07995	COG1414	Transcriptional regulator
AACI_RS08010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AACI_RS08015	COG0174	glutamine synthetase
AACI_RS08020	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AACI_RS08035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AACI_RS08050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AACI_RS08055	COG1181	Belongs to the D-alanine--D-alanine ligase family
AACI_RS08060	COG3935	DnaD domain protein
AACI_RS08065	COG0017	Asparaginyl-tRNA synthetase
AACI_RS08070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AACI_RS08090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AACI_RS08095	COG0402	S-adenosylhomocysteine deaminase activity
AACI_RS08100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AACI_RS08105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AACI_RS08110	COG1793	dna ligase
AACI_RS08110	COG3285	dna ligase
AACI_RS08120	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AACI_RS08125	COG1199	ATP-dependent helicase activity
AACI_RS08125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AACI_RS08140	COG0617	tRNA 3'-terminal CCA addition
AACI_RS08145	COG0438	transferase activity, transferring glycosyl groups
AACI_RS08150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AACI_RS08155	COG1694	Mazg nucleotide pyrophosphohydrolase
AACI_RS08165	COG3314	Sporulation integral membrane protein YlbJ
AACI_RS08170	COG1968	undecaprenyl-diphosphatase activity
AACI_RS08175	COG3949	Membrane
AACI_RS08180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AACI_RS08195	COG0287	Prephenate dehydrogenase
AACI_RS08200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AACI_RS08205	COG0159	tryptophan synthase activity
AACI_RS08210	COG0133	tryptophan synthase activity
AACI_RS08215	COG0135	phosphoribosylanthranilate isomerase activity
AACI_RS08220	COG0134	indole-3-glycerol-phosphate synthase activity
AACI_RS08225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AACI_RS08230	COG4401	Chorismate mutase type I
AACI_RS08235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AACI_RS08240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AACI_RS08255	COG1363	Peptidase, m42
AACI_RS08270	COG1388	LysM domain
AACI_RS08270	COG0791	NLP P60 protein
AACI_RS08280	COG0714	Associated with various cellular activities
AACI_RS08290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AACI_RS08295	COG0517	IMP dehydrogenase activity
AACI_RS08305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AACI_RS08315	COG0105	UTP biosynthetic process
AACI_RS08320	COG0142	geranyltranstransferase activity
AACI_RS08325	COG2226	methyltransferase
AACI_RS08345	COG1064	alcohol dehydrogenase
AACI_RS08350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AACI_RS08355	COG0509	glycine decarboxylation via glycine cleavage system
AACI_RS08365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AACI_RS08370	COG1160	GTP binding
AACI_RS08380	COG0539	negative regulation of cytoplasmic translation
AACI_RS08390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AACI_RS08400	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AACI_RS08420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AACI_RS08425	COG4862	establishment of competence for transformation
AACI_RS08430	COG1609	Transcriptional regulator
AACI_RS08455	COG0210	DNA helicase
AACI_RS08455	COG0210	DNA helicase
AACI_RS08465	COG2226	methyltransferase
AACI_RS08475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AACI_RS08485	COG2339	peptidase activity
AACI_RS08495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AACI_RS08510	COG5002	protein histidine kinase activity
AACI_RS08515	COG0745	RESPONSE REGULATOR receiver
AACI_RS08525	COG1187	pseudouridine synthase activity
AACI_RS08530	COG0700	Nucleoside recognition
AACI_RS08535	COG2715	membrane protein required for spore maturation
AACI_RS08540	COG3874	Sporulation protein YtfJ
AACI_RS08550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AACI_RS08555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AACI_RS08560	COG1994	Peptidase M50
AACI_RS08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AACI_RS08590	COG1191	sigma factor activity
AACI_RS08595	COG2172	sigma factor antagonist activity
AACI_RS08600	COG1366	Belongs to the anti-sigma-factor antagonist family
AACI_RS08610	COG1686	Belongs to the peptidase S11 family
AACI_RS08615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AACI_RS08620	COG4974	Belongs to the 'phage' integrase family
AACI_RS08635	COG1379	DNA repair
AACI_RS08640	COG0494	nUDIX hydrolase
AACI_RS08650	COG0321	lipoyl(octanoyl) transferase activity
AACI_RS08655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AACI_RS08660	COG0315	cyclic pyranopterin monophosphate synthase activity
AACI_RS08665	COG0314	molybdopterin synthase activity
AACI_RS08670	COG3858	chitin binding
AACI_RS08670	COG1388	LysM domain
AACI_RS08710	COG0750	zinc metalloprotease
AACI_RS08715	COG0497	DNA recombination
AACI_RS08720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AACI_RS08730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AACI_RS08750	COG1570	exodeoxyribonuclease VII activity
AACI_RS08755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AACI_RS08760	COG0492	ferredoxin-NADP+ reductase activity
AACI_RS08785	COG1302	Protein conserved in bacteria
AACI_RS08790	COG0439	Biotin carboxylase
AACI_RS08795	COG0511	ligase activity, forming carbon-carbon bonds
AACI_RS08835	COG3854	ATPases associated with a variety of cellular activities
AACI_RS08840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AACI_RS08845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AACI_RS08850	COG0406	alpha-ribazole phosphatase activity
AACI_RS08860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AACI_RS08865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AACI_RS08870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AACI_RS08880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AACI_RS08885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AACI_RS08915	COG1459	type II secretion system
AACI_RS08930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AACI_RS08940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AACI_RS08945	COG2868	ribosomal protein
AACI_RS08955	COG1994	Peptidase M50
AACI_RS08965	COG2894	cell division
AACI_RS08970	COG0850	regulation of cytokinetic process
AACI_RS08985	COG1077	Cell shape determining protein MreB Mrl
AACI_RS08990	COG2003	Belongs to the UPF0758 family
AACI_RS09005	COG3584	3D domain protein
AACI_RS09005	COG3583	domain protein
AACI_RS09010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AACI_RS09015	COG0285	dihydrofolate synthase activity
AACI_RS09020	COG0525	valine-tRNA ligase activity
AACI_RS09035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AACI_RS09040	COG0113	porphobilinogen synthase activity
AACI_RS09050	COG0181	hydroxymethylbilane synthase activity
AACI_RS09060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AACI_RS09065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AACI_RS09075	COG0470	DNA polymerase III
AACI_RS09075	COG1067	ATP-dependent peptidase activity
AACI_RS09080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AACI_RS09085	COG0740	serine-type endopeptidase activity
AACI_RS09090	COG0544	peptidyl-prolyl cis-trans isomerase activity
AACI_RS09105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AACI_RS09110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AACI_RS09115	COG1846	Transcriptional regulator
AACI_RS09120	COG1960	acyl-CoA dehydrogenase activity
AACI_RS09140	COG2197	response regulator
AACI_RS09145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AACI_RS09155	COG2188	Transcriptional regulator
AACI_RS09160	COG2814	Major facilitator Superfamily
AACI_RS09165	COG1054	Belongs to the UPF0176 family
AACI_RS09175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AACI_RS09180	COG1053	succinate dehydrogenase
AACI_RS09185	COG2009	succinate dehydrogenase
AACI_RS09190	COG0322	excinuclease ABC activity
AACI_RS09215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACI_RS09225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AACI_RS09235	COG0387	Pfam Sodium calcium exchanger
AACI_RS09265	COG0463	Glycosyl transferase, family 2
AACI_RS09275	COG1846	Transcriptional regulator
AACI_RS09290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AACI_RS09295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AACI_RS09315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AACI_RS09320	COG0647	UMP catabolic process
AACI_RS09325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AACI_RS09340	COG2076	Multidrug Resistance protein
AACI_RS09345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AACI_RS09360	COG2723	6-phospho-beta-galactosidase activity
AACI_RS09365	COG4608	Belongs to the ABC transporter superfamily
AACI_RS09380	COG0601	transmembrane transport
AACI_RS09405	COG3328	transposase activity
AACI_RS09410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AACI_RS09415	COG0704	Plays a role in the regulation of phosphate uptake
AACI_RS09420	COG0791	NLP P60 protein
AACI_RS09420	COG1388	LysM domain
AACI_RS09425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AACI_RS09445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AACI_RS09465	COG0596	Alpha beta hydrolase
AACI_RS09470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AACI_RS09475	COG1169	isochorismate synthase
AACI_RS09480	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS09485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AACI_RS09490	COG1575	Belongs to the MenA family. Type 1 subfamily
AACI_RS09495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AACI_RS09500	COG2427	Protein of unknown function (DUF1641)
AACI_RS09505	COG3383	formate dehydrogenase (NAD+) activity
AACI_RS09510	COG1331	Highly conserved protein containing a thioredoxin domain
AACI_RS09515	COG1331	Highly conserved protein containing a thioredoxin domain
AACI_RS09525	COG0697	spore germination
AACI_RS09535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AACI_RS09540	COG0351	phosphomethylpyrimidine kinase
AACI_RS09545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AACI_RS09550	COG0352	thiamine-phosphate diphosphorylase activity
AACI_RS09555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AACI_RS09560	COG4988	ABC transporter
AACI_RS09565	COG1294	oxidase, subunit
AACI_RS09570	COG1271	oxidase subunit
AACI_RS09575	COG0477	Major facilitator Superfamily
AACI_RS09580	COG1846	Transcriptional regulator
AACI_RS09590	COG1120	ATPase activity
AACI_RS09595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AACI_RS09600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AACI_RS09620	COG1733	regulation of RNA biosynthetic process
AACI_RS09625	COG0720	synthase
AACI_RS09630	COG0602	queuosine metabolic process
AACI_RS09645	COG0248	Ppx GppA phosphatase
AACI_RS09650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AACI_RS09670	COG0306	phosphate transporter
AACI_RS09675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AACI_RS09690	COG0697	spore germination
AACI_RS09710	COG4191	Histidine kinase
AACI_RS09720	COG1902	pentaerythritol trinitrate reductase activity
AACI_RS09725	COG5002	protein histidine kinase activity
AACI_RS09750	COG0010	Belongs to the arginase family
AACI_RS09755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AACI_RS09760	COG2384	SAM-dependent methyltransferase
AACI_RS09770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AACI_RS09775	COG0358	DNA primase activity
AACI_RS09780	COG1381	Involved in DNA repair and RecF pathway recombination
AACI_RS09785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AACI_RS09795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AACI_RS09800	COG1480	7TM receptor with intracellular HD hydrolase
AACI_RS09805	COG1702	phosphate starvation-inducible protein PhoH
AACI_RS09820	COG1610	YqeY-like protein
AACI_RS09825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AACI_RS09840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AACI_RS09845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AACI_RS09850	COG2264	protein methyltransferase activity
AACI_RS09855	COG0484	heat shock protein binding
AACI_RS09860	COG0443	Heat shock 70 kDa protein
AACI_RS09865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AACI_RS09870	COG1420	regulation of RNA biosynthetic process
AACI_RS09875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AACI_RS09880	COG0481	GTPase activity
AACI_RS09895	COG0741	lytic transglycosylase activity
AACI_RS09905	COG0268	Binds directly to 16S ribosomal RNA
AACI_RS09920	COG1252	NADH dehydrogenase
AACI_RS09930	COG1555	photosystem II stabilization
AACI_RS09930	COG1596	polysaccharide export
AACI_RS09935	COG1321	iron dependent repressor
AACI_RS09940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AACI_RS09940	COG2226	methyltransferase
AACI_RS09940	COG0596	Alpha beta hydrolase
AACI_RS09945	COG0799	negative regulation of ribosome biogenesis
AACI_RS09950	COG1713	HD superfamily hydrolase involved in NAD metabolism
AACI_RS09955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AACI_RS09960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AACI_RS09965	COG1160	GTP binding
AACI_RS09985	COG2226	methyltransferase
AACI_RS10000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AACI_RS10010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AACI_RS10015	COG0628	permease
AACI_RS10025	COG1104	cysteine desulfurase activity
AACI_RS10030	COG1959	2 iron, 2 sulfur cluster binding
AACI_RS10045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AACI_RS10055	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS10065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AACI_RS10070	COG0124	histidyl-tRNA synthetase
AACI_RS10075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AACI_RS10090	COG1131	(ABC) transporter
AACI_RS10100	COG2814	Major facilitator Superfamily
AACI_RS10110	COG1175	transmembrane transport
AACI_RS10115	COG0395	ABC-type sugar transport system, permease component
AACI_RS10130	COG1024	Enoyl-CoA hydratase
AACI_RS10135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AACI_RS10140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AACI_RS10145	COG0511	ligase activity, forming carbon-carbon bonds
AACI_RS10150	COG0439	Biotin carboxylase
AACI_RS10155	COG0439	Biotin carboxylase
AACI_RS10160	COG1960	acyl-CoA dehydrogenase activity
AACI_RS10175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AACI_RS10180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AACI_RS10190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AACI_RS10195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AACI_RS10195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AACI_RS10200	COG1250	3-hydroxyacyl-CoA dehydrogenase
AACI_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS10215	COG2211	Major facilitator Superfamily
AACI_RS10225	COG0667	Aldo Keto reductase
AACI_RS10230	COG0303	'Molybdopterin
AACI_RS10235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AACI_RS10250	COG1074	ATP-dependent DNA helicase activity
AACI_RS10255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AACI_RS10260	COG0477	Major facilitator Superfamily
AACI_RS10265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AACI_RS10270	COG0531	amino acid
AACI_RS10280	COG3829	transcription factor binding
AACI_RS10280	COG3290	protein histidine kinase activity
AACI_RS10285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AACI_RS10295	COG1686	Belongs to the peptidase S11 family
AACI_RS10315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AACI_RS10320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AACI_RS10325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AACI_RS10340	COG3300	MHYT domain
AACI_RS10340	COG5001	Diguanylate cyclase
AACI_RS10350	COG1490	D-aminoacyl-tRNA deacylase activity
AACI_RS10355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AACI_RS10360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AACI_RS10365	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AACI_RS10365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AACI_RS10370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AACI_RS10375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AACI_RS10380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AACI_RS10390	COG2244	polysaccharide biosynthetic process
AACI_RS10400	COG2203	Gaf domain
AACI_RS10400	COG4251	negative regulation of phosphorylation
AACI_RS10400	COG3706	GGDEF domain
AACI_RS10400	COG5001	Diguanylate cyclase
AACI_RS10415	COG0343	queuine tRNA-ribosyltransferase activity
AACI_RS10420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AACI_RS10425	COG4447	cellulose binding
AACI_RS10430	COG1191	sigma factor activity
AACI_RS10435	COG2255	four-way junction helicase activity
AACI_RS10440	COG0632	four-way junction helicase activity
AACI_RS10445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AACI_RS10455	COG0217	transcriptional regulatory protein
AACI_RS10465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AACI_RS10465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AACI_RS10485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AACI_RS10490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AACI_RS10495	COG1193	negative regulation of DNA recombination
AACI_RS10510	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AACI_RS10515	COG0072	phenylalanine-tRNA ligase activity
AACI_RS10515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AACI_RS10520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AACI_RS10525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AACI_RS10530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AACI_RS10535	COG1830	Aldolase
AACI_RS10540	COG0205	6-phosphofructokinase activity
AACI_RS10545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AACI_RS10550	COG0840	transmembrane signaling receptor activity
AACI_RS10555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AACI_RS10560	COG3842	ATPase activity
AACI_RS10575	COG0579	oxidoreductase
AACI_RS10580	COG0508	dehydrogenase complex catalyzes the overall conversion of
AACI_RS10585	COG0567	Dehydrogenase, E1 component
AACI_RS10595	COG0714	Associated with various cellular activities
AACI_RS10610	COG1482	cell wall glycoprotein biosynthetic process
AACI_RS10615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AACI_RS10635	COG0673	inositol 2-dehydrogenase activity
AACI_RS10640	COG1082	Xylose isomerase domain protein TIM barrel
AACI_RS10665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AACI_RS10670	COG0697	spore germination
AACI_RS10675	COG1214	PFAM Peptidase M22, glycoprotease
AACI_RS10675	COG0456	acetyltransferase
AACI_RS10680	COG2267	carboxylic ester hydrolase activity
AACI_RS10685	COG0531	amino acid
AACI_RS10690	COG3546	catalase activity
AACI_RS10705	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AACI_RS10710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AACI_RS10715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AACI_RS10720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AACI_RS10740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AACI_RS10760	COG1070	Carbohydrate kinase
AACI_RS10765	COG2115	Belongs to the xylose isomerase family
AACI_RS10775	COG1408	metallophosphoesterase
AACI_RS10800	COG0300	oxidoreductase activity
AACI_RS10860	COG1278	Cold shock
AACI_RS10875	COG0667	Aldo Keto reductase
AACI_RS10880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AACI_RS10900	COG4989	oxidoreductase activity
AACI_RS10905	COG1082	Xylose isomerase domain protein TIM barrel
AACI_RS10915	COG2154	pterin-4-alpha-carbinolamine dehydratase
AACI_RS10950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AACI_RS10970	COG0577	efflux transmembrane transporter activity
AACI_RS10975	COG1136	(ABC) transporter
AACI_RS10990	COG0517	IMP dehydrogenase activity
AACI_RS11000	COG0372	Belongs to the citrate synthase family
AACI_RS11005	COG1971	Probably functions as a manganese efflux pump
AACI_RS11010	COG0285	dihydrofolate synthase activity
AACI_RS11015	COG0066	3-isopropylmalate dehydratase activity
AACI_RS11020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AACI_RS11025	COG0473	3-isopropylmalate dehydrogenase activity
AACI_RS11030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AACI_RS11035	COG0440	acetolactate synthase activity
AACI_RS11040	COG0028	Belongs to the TPP enzyme family
AACI_RS11045	COG0129	dihydroxy-acid dehydratase activity
AACI_RS11055	COG0460	homoserine dehydrogenase
AACI_RS11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AACI_RS11075	COG1653	transport
AACI_RS11100	COG0450	alkyl hydroperoxide reductase
AACI_RS11105	COG1959	2 iron, 2 sulfur cluster binding
AACI_RS11115	COG3858	chitin binding
AACI_RS11115	COG1388	LysM domain
AACI_RS11120	COG0833	amino acid
AACI_RS11150	COG1132	(ABC) transporter
AACI_RS11155	COG1132	(ABC) transporter
AACI_RS11170	COG0747	negative chemotaxis
AACI_RS11175	COG0601	transmembrane transport
AACI_RS11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AACI_RS11185	COG0747	negative chemotaxis
AACI_RS11190	COG4608	Belongs to the ABC transporter superfamily
AACI_RS11195	COG0444	Belongs to the ABC transporter superfamily
AACI_RS11200	COG0745	RESPONSE REGULATOR receiver
AACI_RS11210	COG0095	Lipoate-protein ligase
AACI_RS11215	COG5002	protein histidine kinase activity
AACI_RS11220	COG0745	RESPONSE REGULATOR receiver
AACI_RS11225	COG0583	DNA-binding transcription factor activity
AACI_RS11235	COG0708	Exodeoxyribonuclease III
AACI_RS11250	COG2390	Transcriptional regulator
AACI_RS11255	COG1072	(Pantothenic acid kinase))
AACI_RS11260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AACI_RS11265	COG1879	ABC-type sugar transport system periplasmic component
AACI_RS11270	COG1172	Belongs to the binding-protein-dependent transport system permease family
AACI_RS11275	COG1129	ABC transporter
AACI_RS11280	COG1869	D-ribose catabolic process
AACI_RS11285	COG1609	Transcriptional regulator
AACI_RS11290	COG1132	(ABC) transporter
AACI_RS11295	COG1132	(ABC) transporter
AACI_RS11310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AACI_RS11320	COG1218	3'(2'),5'-bisphosphate nucleotidase
AACI_RS11325	COG1312	Catalyzes the dehydration of D-mannonate
AACI_RS11330	COG0352	thiamine-phosphate diphosphorylase activity
AACI_RS11340	COG1929	Belongs to the glycerate kinase type-1 family
AACI_RS11390	COG2814	Major facilitator Superfamily
AACI_RS11405	COG0840	transmembrane signaling receptor activity
AACI_RS11410	COG1653	transport
AACI_RS11450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AACI_RS11485	COG1349	DNA-binding transcription factor activity
AACI_RS11490	COG1085	galactose-1-phosphate uridylyltransferase
AACI_RS11495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AACI_RS11520	COG1063	alcohol dehydrogenase
AACI_RS11525	COG0668	transmembrane transport
AACI_RS11530	COG0768	penicillin binding
AACI_RS11560	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AACI_RS11580	COG1827	regulation of RNA biosynthetic process
AACI_RS11590	COG0237	dephospho-CoA kinase activity
AACI_RS11595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AACI_RS11605	COG1605	Chorismate mutase
AACI_RS11605	COG0077	Prephenate dehydratase
AACI_RS11615	COG0538	isocitrate dehydrogenase activity
AACI_RS11625	COG0745	RESPONSE REGULATOR receiver
AACI_RS11630	COG0180	Tryptophanyl-tRNA synthetase
AACI_RS11635	COG0469	pyruvate kinase activity
AACI_RS11640	COG0825	malonyl-CoA metabolic process
AACI_RS11645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AACI_RS11655	COG0587	DNA-directed DNA polymerase activity
AACI_RS11660	COG4109	DRTGG domain
AACI_RS11665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AACI_RS11685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AACI_RS11690	COG1438	arginine binding
AACI_RS11695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AACI_RS11710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AACI_RS11715	COG3679	Belongs to the UPF0342 family
AACI_RS11720	COG2346	COG2346, Truncated hemoglobins
AACI_RS11730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AACI_RS11745	COG2267	carboxylic ester hydrolase activity
AACI_RS11750	COG1045	serine acetyltransferase
AACI_RS11755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AACI_RS11765	COG4496	protein, YerC YecD
AACI_RS11775	COG2132	Multicopper oxidase
AACI_RS11790	COG1396	sequence-specific DNA binding
AACI_RS11820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AACI_RS11840	COG1063	alcohol dehydrogenase
AACI_RS11845	COG1960	acyl-CoA dehydrogenase activity
AACI_RS11850	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS11855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AACI_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS11865	COG0446	pyridine nucleotide-disulphide oxidoreductase
AACI_RS11865	COG1902	pentaerythritol trinitrate reductase activity
AACI_RS11870	COG0318	PFAM AMP-dependent synthetase and ligase
AACI_RS11875	COG1960	acyl-CoA dehydrogenase activity
AACI_RS11880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AACI_RS11890	COG1376	ErfK ybiS ycfS ynhG family protein
AACI_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
AACI_RS11925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AACI_RS11935	COG0667	Aldo Keto reductase
AACI_RS11945	COG0840	transmembrane signaling receptor activity
AACI_RS11955	COG0788	formyltetrahydrofolate deformylase activity
AACI_RS11970	COG1587	Uroporphyrinogen-III synthase
AACI_RS11970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AACI_RS11975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AACI_RS11980	COG0175	sulfate reduction
AACI_RS11985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AACI_RS11985	COG1648	precorrin-2 dehydrogenase activity
AACI_RS11990	COG2814	Major facilitator Superfamily
AACI_RS11995	COG1566	PFAM secretion protein HlyD family protein
AACI_RS12000	COG0768	penicillin binding
AACI_RS12005	COG1215	transferase activity, transferring glycosyl groups
AACI_RS12010	COG3103	Sh3 type 3 domain protein
AACI_RS12010	COG1388	LysM domain
AACI_RS12010	COG0791	NLP P60 protein
AACI_RS12015	COG1809	phosphosulfolactate synthase activity
AACI_RS12025	COG0531	amino acid
AACI_RS12040	COG0697	spore germination
AACI_RS12045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AACI_RS12060	COG1562	ergosterol biosynthetic process
AACI_RS12065	COG1657	PFAM Prenyltransferase squalene oxidase
AACI_RS12070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AACI_RS12080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AACI_RS12085	COG1304	FMN binding
AACI_RS12090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AACI_RS12125	COG2132	Multicopper oxidase
AACI_RS12130	COG2132	Multicopper oxidase
AACI_RS12140	COG0395	ABC-type sugar transport system, permease component
AACI_RS12145	COG1175	transmembrane transport
AACI_RS12160	COG0673	inositol 2-dehydrogenase activity
AACI_RS12165	COG1609	Transcriptional regulator
AACI_RS12190	COG0004	ammonium transporteR
AACI_RS12195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AACI_RS12210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AACI_RS12215	COG0601	transmembrane transport
AACI_RS12220	COG4166	transmembrane transport
AACI_RS12225	COG3291	Pkd domain containing protein
AACI_RS12230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AACI_RS12235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AACI_RS12250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AACI_RS12255	COG2022	thiamine diphosphate biosynthetic process
AACI_RS12265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AACI_RS12270	COG0352	thiamine-phosphate diphosphorylase activity
AACI_RS12275	COG1227	inorganic diphosphatase activity
AACI_RS12285	COG2814	Major facilitator Superfamily
AACI_RS12300	COG0789	Transcriptional regulator
AACI_RS12320	COG1090	epimerase
AACI_RS12325	COG2271	Major facilitator Superfamily
AACI_RS12355	COG0693	protein deglycase activity
AACI_RS12360	COG0840	transmembrane signaling receptor activity
AACI_RS12365	COG0531	amino acid
AACI_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
AACI_RS12390	COG0457	Tetratricopeptide repeat
AACI_RS12390	COG0463	Glycosyl transferase, family 2
AACI_RS12400	COG0583	DNA-binding transcription factor activity
AACI_RS12420	COG2271	Major facilitator Superfamily
AACI_RS12430	COG1063	alcohol dehydrogenase
AACI_RS12440	COG0450	alkyl hydroperoxide reductase
AACI_RS12445	COG0735	belongs to the Fur family
AACI_RS12460	COG1113	amino acid transport
AACI_RS12470	COG2204	response regulator
AACI_RS12475	COG0277	FAD linked oxidase domain protein
AACI_RS12480	COG2271	Major facilitator Superfamily
AACI_RS12485	COG2267	carboxylic ester hydrolase activity
AACI_RS12490	COG1620	l-lactate permease
AACI_RS12495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AACI_RS12500	COG1414	Transcriptional regulator
AACI_RS12505	COG0277	FAD linked oxidase domain protein
AACI_RS12510	COG0247	lactate metabolic process
AACI_RS12515	COG0277	FAD linked oxidase domain protein
AACI_RS12520	COG1215	transferase activity, transferring glycosyl groups
AACI_RS12535	COG0640	Transcriptional regulator
AACI_RS12580	COG2255	four-way junction helicase activity
AACI_RS12600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AACI_RS12605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AACI_RS12610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AACI_RS12615	COG0653	protein targeting
AACI_RS12620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AACI_RS12640	COG1216	Glycosyl transferase, family 2
AACI_RS12645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AACI_RS12650	COG0463	Glycosyl transferase, family 2
AACI_RS12650	COG0457	Tetratricopeptide repeat
AACI_RS12660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AACI_RS12665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AACI_RS12695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AACI_RS12700	COG5002	protein histidine kinase activity
AACI_RS12705	COG0745	RESPONSE REGULATOR receiver
AACI_RS12720	COG2197	response regulator
AACI_RS12725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AACI_RS12735	COG2814	Major facilitator Superfamily
AACI_RS12740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AACI_RS12745	COG0154	amidase activity
AACI_RS12750	COG0315	cyclic pyranopterin monophosphate synthase activity
AACI_RS12750	COG0521	Mo-molybdopterin cofactor biosynthetic process
AACI_RS12755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AACI_RS12760	COG1073	alpha beta
AACI_RS12815	COG0384	phenazine biosynthesis protein PhzF
AACI_RS12820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AACI_RS12830	COG1187	pseudouridine synthase activity
AACI_RS12865	COG0667	Aldo Keto reductase
AACI_RS12870	COG0785	Cytochrome C biogenesis protein
AACI_RS12875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AACI_RS12915	COG0477	Major facilitator Superfamily
AACI_RS12920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AACI_RS12925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AACI_RS12940	COG2814	Major facilitator Superfamily
AACI_RS12955	COG0803	Belongs to the bacterial solute-binding protein 9 family
AACI_RS12960	COG1121	(ABC) transporter
AACI_RS12975	COG1607	acyl-coa hydrolase
AACI_RS12990	COG5001	Diguanylate cyclase
AACI_RS12990	COG3300	MHYT domain
AACI_RS12995	COG0673	inositol 2-dehydrogenase activity
AACI_RS13000	COG2814	Major facilitator Superfamily
AACI_RS13010	COG1276	copper resistance
AACI_RS13010	COG2372	response to copper ion
AACI_RS13015	COG4549	nuclear export factor GLE1
AACI_RS13020	COG0306	phosphate transporter
AACI_RS13040	COG1472	Belongs to the glycosyl hydrolase 3 family
AACI_RS13045	COG0671	phosphoesterase, PA-phosphatase related
AACI_RS13060	COG1595	DNA-templated transcription, initiation
AACI_RS13085	COG1937	Protein conserved in bacteria
AACI_RS13095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AACI_RS13095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACI_RS13100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACI_RS13100	COG0425	Belongs to the sulfur carrier protein TusA family
AACI_RS13105	COG2210	Belongs to the sulfur carrier protein TusA family
AACI_RS13110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AACI_RS13115	COG0730	response to heat
AACI_RS13140	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AACI_RS13145	COG1518	maintenance of DNA repeat elements
AACI_RS13155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AACI_RS13170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AACI_RS13180	COG1937	Protein conserved in bacteria
AACI_RS13185	COG1302	Protein conserved in bacteria
AACI_RS13200	COG1302	Protein conserved in bacteria
AACI_RS13205	COG1522	sequence-specific DNA binding
AACI_RS13210	COG0436	Aminotransferase
AACI_RS13220	COG1064	alcohol dehydrogenase
AACI_RS13225	COG1309	transcriptional regulator
AACI_RS13230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AACI_RS13235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AACI_RS13240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AACI_RS13245	COG4856	YbbR-like protein
AACI_RS13250	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AACI_RS13260	COG0726	polysaccharide deacetylase
AACI_RS13270	COG0489	protein tyrosine kinase activity
AACI_RS13280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AACI_RS13285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AACI_RS13290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AACI_RS13295	COG0101	tRNA pseudouridine synthase activity
AACI_RS13300	COG0203	ribosomal protein L17
AACI_RS13305	COG0202	RNA polymerase activity
AACI_RS13310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AACI_RS13315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AACI_RS13320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AACI_RS13325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AACI_RS13330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AACI_RS13340	COG0563	adenylate kinase activity
AACI_RS13345	COG0201	protein transport
AACI_RS13360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AACI_RS13365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AACI_RS13370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AACI_RS13375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AACI_RS13380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AACI_RS13385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AACI_RS13390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AACI_RS13395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AACI_RS13405	COG0255	Belongs to the universal ribosomal protein uL29 family
AACI_RS13410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AACI_RS13415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AACI_RS13420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AACI_RS13425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AACI_RS13430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AACI_RS13435	COG0089	rRNA binding
AACI_RS13445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AACI_RS13450	COG0051	transcription antitermination factor activity, RNA binding
AACI_RS13455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AACI_RS13460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AACI_RS13465	COG0049	tRNA binding
AACI_RS13475	COG1358	cellular component organization or biogenesis
AACI_RS13480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AACI_RS13485	COG0085	RNA polymerase activity
AACI_RS13490	COG2813	Specifically methylates the guanine in position
AACI_RS13495	COG0222	ribosome binding
AACI_RS13500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AACI_RS13505	COG0081	regulation of translation
AACI_RS13510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AACI_RS13515	COG0250	Participates in transcription elongation, termination and antitermination
AACI_RS13525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AACI_RS13540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AACI_RS13545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AACI_RS13550	COG0215	cysteine-tRNA ligase activity
AACI_RS13555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AACI_RS13560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AACI_RS13565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AACI_RS13570	COG4956	integral membrane protein (PIN domain superfamily)
AACI_RS13575	COG1183	phosphatidylcholine synthase activity
AACI_RS13580	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AACI_RS13585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AACI_RS13590	COG0542	response to heat
AACI_RS13595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AACI_RS13600	COG3880	PFAM UvrB UvrC protein
AACI_RS13605	COG4463	regulation of RNA biosynthetic process
AACI_RS13615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AACI_RS13620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AACI_RS13625	COG4786	Flagellar basal body rod
AACI_RS13630	COG4786	Flagellar basal body rod
AACI_RS13640	COG1609	Transcriptional regulator
AACI_RS13645	COG0739	heme binding
AACI_RS13655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AACI_RS13670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AACI_RS13675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AACI_RS13680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AACI_RS13685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AACI_RS13690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AACI_RS13695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AACI_RS13700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AACI_RS13705	COG0356	it plays a direct role in the translocation of protons across the membrane
AACI_RS13720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AACI_RS13725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AACI_RS13730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AACI_RS13740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AACI_RS13745	COG1971	Probably functions as a manganese efflux pump
AACI_RS13755	COG3619	membrane
AACI_RS13775	COG0009	L-threonylcarbamoyladenylate synthase
AACI_RS13785	COG2890	protein-(glutamine-N5) methyltransferase activity
AACI_RS13790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AACI_RS13795	COG0254	rRNA binding
AACI_RS13800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AACI_RS13805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AACI_RS13815	COG0504	CTP synthase activity
AACI_RS13820	COG3343	RNA polymerase activity
AACI_RS13825	COG1024	Enoyl-CoA hydratase
AACI_RS13830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AACI_RS13835	COG1984	allophanate hydrolase subunit 2
AACI_RS13840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AACI_RS13845	COG1216	Glycosyl transferase, family 2
AACI_RS13845	COG1442	glycosyl transferase family 8
AACI_RS13860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AACI_RS13865	COG1960	acyl-CoA dehydrogenase activity
AACI_RS13875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AACI_RS13880	COG0436	Aminotransferase
AACI_RS13910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AACI_RS13915	COG1803	Methylglyoxal synthase
AACI_RS13920	COG0006	proline dipeptidase activity
AACI_RS13940	COG2271	Major facilitator Superfamily
AACI_RS13945	COG1070	Carbohydrate kinase
AACI_RS13960	COG2855	membrane
AACI_RS13970	COG0302	gtp cyclohydrolase
AACI_RS13975	COG0142	geranyltranstransferase activity
AACI_RS13990	COG2124	cytochrome p450
AACI_RS13990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AACI_RS14000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AACI_RS14005	COG1215	transferase activity, transferring glycosyl groups
AACI_RS14020	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AACI_RS14025	COG2318	DinB family
AACI_RS14035	COG1609	Transcriptional regulator
AACI_RS14040	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AACI_RS14045	COG0813	purine-nucleoside phosphorylase activity
AACI_RS14050	COG2171	N-acyltransferase activity
AACI_RS14055	COG1473	amidohydrolase
AACI_RS14060	COG0436	Aminotransferase
AACI_RS14080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AACI_RS14090	COG4208	sulfate ABC transporter
AACI_RS14095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AACI_RS14100	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AACI_RS14105	COG1116	anion transmembrane transporter activity
AACI_RS14110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AACI_RS14115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AACI_RS14120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AACI_RS14125	COG0431	NADPH-dependent FMN reductase
AACI_RS14130	COG0789	Transcriptional regulator
AACI_RS14135	COG1960	acyl-CoA dehydrogenase activity
AACI_RS14145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AACI_RS14155	COG0156	8-amino-7-oxononanoate synthase activity
AACI_RS14160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AACI_RS14170	COG0390	transport system, permease component
AACI_RS14175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AACI_RS14180	COG2130	NADP-dependent
AACI_RS14200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AACI_RS14230	COG1609	Transcriptional regulator
AACI_RS14235	COG3833	ABC-type maltose transport systems, permease component
AACI_RS14240	COG1175	transmembrane transport
AACI_RS14265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AACI_RS14275	COG0477	Major facilitator Superfamily
AACI_RS14295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AACI_RS14300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AACI_RS14310	COG1501	Belongs to the glycosyl hydrolase 31 family
AACI_RS14315	COG0589	response to stress
AACI_RS14320	COG4166	transmembrane transport
AACI_RS14335	COG1874	Beta-galactosidase
AACI_RS14340	COG0004	ammonium transporteR
AACI_RS14345	COG0347	Belongs to the P(II) protein family
AACI_RS14365	COG2160	L-arabinose isomerase activity
AACI_RS14375	COG1069	ribulokinase activity
AACI_RS14380	COG2814	Major facilitator Superfamily
AACI_RS14385	COG1609	Transcriptional regulator
AACI_RS14395	COG1172	Belongs to the binding-protein-dependent transport system permease family
AACI_RS14400	COG1129	ABC transporter
AACI_RS14405	COG1609	Transcriptional regulator
AACI_RS14425	COG2814	Major facilitator Superfamily
AACI_RS14430	COG1566	PFAM secretion protein HlyD family protein
AACI_RS14435	COG0484	heat shock protein binding
AACI_RS14440	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AACI_RS14445	COG2203	Gaf domain
AACI_RS14445	COG3706	GGDEF domain
AACI_RS14445	COG4251	negative regulation of phosphorylation
AACI_RS14445	COG5001	Diguanylate cyclase
AACI_RS14455	COG0583	DNA-binding transcription factor activity
AACI_RS14465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AACI_RS14470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AACI_RS14485	COG5002	protein histidine kinase activity
AACI_RS14490	COG0745	RESPONSE REGULATOR receiver
AACI_RS14500	COG0305	Participates in initiation and elongation during chromosome replication
AACI_RS14505	COG0359	binds to the 23S rRNA
AACI_RS14520	COG0629	single-stranded DNA binding
AACI_RS14525	COG0360	Binds together with S18 to 16S ribosomal RNA
AACI_RS14530	COG0012	GTP binding
AACI_RS14535	COG0243	molybdopterin cofactor binding
AACI_RS14540	COG4481	Protein conserved in bacteria
AACI_RS14545	COG0668	transmembrane transport
AACI_RS14565	COG1811	Na channel or pump
AACI_RS14570	COG1475	DNA binding
AACI_RS14575	COG1192	Involved in chromosome partitioning
AACI_RS14580	COG1475	DNA binding
AACI_RS14585	COG0357	Ribosomal RNA small subunit methyltransferase G
AACI_RS14590	COG0445	tRNA wobble uridine modification
AACI_RS14595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AACI_RS14600	COG1847	R3H domain protein
AACI_RS14605	COG0706	membrane insertase activity
AACI_RS14610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AACI_RS14620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AACI_RS14645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AACI_RS14840	COG3845	ABC transporter
AACI_RS15045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AACI_RS15070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AACI_RS15115	COG0517	IMP dehydrogenase activity
AACI_RS15115	COG0516	GMP reductase activity
AACI_RS15290	COG0745	RESPONSE REGULATOR receiver
AACI_RS15530	COG1525	nuclease
AACI_RS15565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AACI_RS15590	COG1396	sequence-specific DNA binding
AACI_RS15595	COG3437	response regulator, receiver
AACI_RS15600	COG1136	(ABC) transporter
AACI_RS15605	COG1595	DNA-templated transcription, initiation
AACI_RS15625	COG0596	Alpha beta hydrolase