locus-tag	class	description
TC41_RS00010	COG0592	DNA-directed DNA polymerase activity
TC41_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TC41_RS00025	COG0187	DNA topoisomerase II activity
TC41_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TC41_RS00065	COG0517	IMP dehydrogenase activity
TC41_RS00065	COG0516	GMP reductase activity
TC41_RS00070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TC41_RS00075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TC41_RS00105	COG4372	Transposase
TC41_RS00125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TC41_RS00145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TC41_RS00150	COG2224	Isocitrate lyase
TC41_RS00175	COG1079	Belongs to the binding-protein-dependent transport system permease family
TC41_RS00190	COG1744	ABC transporter substrate-binding protein PnrA-like
TC41_RS00200	COG1335	isochorismatase
TC41_RS00205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_RS00210	COG0824	Thioesterase
TC41_RS00220	COG3842	ATPase activity
TC41_RS00245	COG0667	Aldo Keto reductase
TC41_RS00250	COG0656	L-ascorbic acid biosynthetic process
TC41_RS00255	COG2207	Transcriptional regulator
TC41_RS00260	COG0745	RESPONSE REGULATOR receiver
TC41_RS00265	COG5002	protein histidine kinase activity
TC41_RS00275	COG1279	arginine transmembrane transporter activity
TC41_RS00290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TC41_RS00295	COG2814	Major facilitator Superfamily
TC41_RS00300	COG0789	Transcriptional regulator
TC41_RS00305	COG0747	negative chemotaxis
TC41_RS00315	COG1392	Phosphate transport regulator
TC41_RS00325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TC41_RS00335	COG1802	Transcriptional regulator
TC41_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS00365	COG4191	Histidine kinase
TC41_RS00370	COG1289	transmembrane transporter activity
TC41_RS00385	COG0194	GDP metabolic process
TC41_RS00400	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS00415	COG0644	oxidoreductase
TC41_RS00415	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
TC41_RS00420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TC41_RS00425	COG0584	glycerophosphoryl diester phosphodiesterase
TC41_RS00435	COG0395	ABC-type sugar transport system, permease component
TC41_RS00440	COG1175	transmembrane transport
TC41_RS00445	COG2309	aminopeptidase activity
TC41_RS00455	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TC41_RS00460	COG1309	transcriptional regulator
TC41_RS00465	COG1511	domain protein
TC41_RS00470	COG3973	AAA domain
TC41_RS00475	COG0588	phosphoglycerate mutase activity
TC41_RS00485	COG1940	carbohydrate kinase activity
TC41_RS00530	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TC41_RS00540	COG1850	ribulose-bisphosphate carboxylase activity
TC41_RS00545	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
TC41_RS00550	COG0235	Class ii aldolase
TC41_RS00560	COG0367	asparagine synthase
TC41_RS00570	COG0590	tRNA wobble adenosine to inosine editing
TC41_RS00580	COG3852	Histidine kinase
TC41_RS00590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TC41_RS00595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TC41_RS00600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TC41_RS00605	COG1970	mechanosensitive ion channel activity
TC41_RS00615	COG0477	Major facilitator Superfamily
TC41_RS00620	COG0235	Class ii aldolase
TC41_RS00625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_RS00625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_RS00635	COG0840	transmembrane signaling receptor activity
TC41_RS00640	COG2201	protein-glutamate methylesterase activity
TC41_RS00650	COG0840	transmembrane signaling receptor activity
TC41_RS00655	COG2198	Histidine kinase
TC41_RS00655	COG0643	Histidine kinase
TC41_RS00660	COG0835	chemotaxis
TC41_RS00670	COG4372	Transposase
TC41_RS00675	COG4372	Transposase
TC41_RS00700	COG2244	polysaccharide biosynthetic process
TC41_RS00710	COG1982	Orn Lys Arg decarboxylase major
TC41_RS00715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TC41_RS00720	COG3870	Protein conserved in bacteria
TC41_RS00725	COG0470	DNA polymerase III
TC41_RS00730	COG1774	PSP1 C-terminal conserved region
TC41_RS00735	COG4467	Involved in initiation control of chromosome replication
TC41_RS00745	COG2002	toxin-antitoxin pair type II binding
TC41_RS00755	COG0084	hydrolase, TatD family'
TC41_RS00765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TC41_RS00775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_RS00820	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS00830	COG1960	acyl-CoA dehydrogenase activity
TC41_RS00835	COG1024	Enoyl-CoA hydratase
TC41_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TC41_RS00870	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS00875	COG1454	alcohol dehydrogenase
TC41_RS00885	COG1960	acyl-CoA dehydrogenase activity
TC41_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS00900	COG1960	acyl-CoA dehydrogenase activity
TC41_RS00905	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS00910	COG2030	dehydratase
TC41_RS00960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
TC41_RS00975	COG3328	transposase activity
TC41_RS01030	COG4466	Protein conserved in bacteria
TC41_RS01050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TC41_RS01055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_RS01060	COG0251	oxidation-reduction process
TC41_RS01065	COG2088	sporulation resulting in formation of a cellular spore
TC41_RS01070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TC41_RS01075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TC41_RS01080	COG0193	aminoacyl-tRNA hydrolase activity
TC41_RS01090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TC41_RS01105	COG3956	TIGRFAM MazG family protein
TC41_RS01115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TC41_RS01135	COG1098	S1 RNA binding domain
TC41_RS01145	COG2131	deaminase
TC41_RS01150	COG2208	phosphoserine phosphatase activity
TC41_RS01155	COG2304	oxidoreductase activity
TC41_RS01165	COG0037	tRNA processing
TC41_RS01170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TC41_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TC41_RS01190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TC41_RS01195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TC41_RS01200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TC41_RS01205	COG1396	sequence-specific DNA binding
TC41_RS01210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TC41_RS01240	COG2318	DinB family
TC41_RS01245	COG1968	undecaprenyl-diphosphatase activity
TC41_RS01250	COG2223	nitrite transmembrane transporter activity
TC41_RS01255	COG0697	spore germination
TC41_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS01270	COG0436	Aminotransferase
TC41_RS01275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TC41_RS01290	COG3711	transcriptional antiterminator
TC41_RS01300	COG0246	Mannitol dehydrogenase
TC41_RS01305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_RS01310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TC41_RS01315	COG1595	DNA-templated transcription, initiation
TC41_RS01355	COG1122	ATPase activity
TC41_RS01360	COG1122	ATPase activity
TC41_RS01365	COG1268	BioY protein
TC41_RS01380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS01410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TC41_RS01425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TC41_RS01430	COG2814	Major facilitator Superfamily
TC41_RS01435	COG0583	DNA-binding transcription factor activity
TC41_RS01445	COG0745	RESPONSE REGULATOR receiver
TC41_RS01450	COG2205	protein histidine kinase activity
TC41_RS01455	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TC41_RS01460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TC41_RS01465	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TC41_RS01470	COG2205	protein histidine kinase activity
TC41_RS01480	COG0667	Aldo Keto reductase
TC41_RS01490	COG2814	Major facilitator Superfamily
TC41_RS01495	COG3858	chitin binding
TC41_RS01495	COG1388	LysM domain
TC41_RS01500	COG4213	ABC transporter substrate-binding protein
TC41_RS01510	COG4214	carbohydrate transport
TC41_RS01525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_RS01530	COG0386	Belongs to the glutathione peroxidase family
TC41_RS01635	COG1739	Uncharacterized protein family UPF0029
TC41_RS01660	COG0463	Glycosyl transferase, family 2
TC41_RS01665	COG1674	ftsk spoiiie
TC41_RS01685	COG4974	Belongs to the 'phage' integrase family
TC41_RS01715	COG1674	ftsk spoiiie
TC41_RS01750	COG4372	Transposase
TC41_RS01760	COG1566	PFAM secretion protein HlyD family protein
TC41_RS01765	COG2814	Major facilitator Superfamily
TC41_RS01800	COG1136	(ABC) transporter
TC41_RS01800	COG4591	ABC-type transport system involved in lipoprotein release permease component
TC41_RS01805	COG1136	(ABC) transporter
TC41_RS01805	COG0577	efflux transmembrane transporter activity
TC41_RS01815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TC41_RS01820	COG0420	3'-5' exonuclease activity
TC41_RS01825	COG0419	ATPase involved in DNA repair
TC41_RS01830	COG2814	Major facilitator Superfamily
TC41_RS01835	COG2217	Heavy metal translocating P-type atpase
TC41_RS01840	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS01850	COG1595	DNA-templated transcription, initiation
TC41_RS01860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TC41_RS01865	COG0805	protein transport
TC41_RS01870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TC41_RS01875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TC41_RS01900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TC41_RS01915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TC41_RS01995	COG1205	dead DEAH box helicase
TC41_RS01995	COG1111	helicase
TC41_RS02005	COG3829	transcription factor binding
TC41_RS02010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TC41_RS02045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TC41_RS02050	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS02055	COG3829	transcription factor binding
TC41_RS02060	COG0833	amino acid
TC41_RS02070	COG1132	(ABC) transporter
TC41_RS02075	COG1132	(ABC) transporter
TC41_RS02095	COG5263	repeat protein
TC41_RS02095	COG4193	domain, Protein
TC41_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS02105	COG1917	Cupin 2, conserved barrel domain protein
TC41_RS02105	COG4977	sequence-specific DNA binding
TC41_RS02120	COG1472	Belongs to the glycosyl hydrolase 3 family
TC41_RS02130	COG2814	Major facilitator Superfamily
TC41_RS02140	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_RS02145	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS02160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TC41_RS02165	COG2409	Drug exporters of the RND superfamily
TC41_RS02165	COG1033	growth of symbiont in host cell
TC41_RS02170	COG4846	Membrane protein involved in cytochrome C biogenesis
TC41_RS02180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_RS02200	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TC41_RS02205	COG0024	Methionine aminopeptidase
TC41_RS02225	COG0736	holo-[acyl-carrier-protein] synthase activity
TC41_RS02230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TC41_RS02230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TC41_RS02235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TC41_RS02240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TC41_RS02250	COG2337	Toxic component of a toxin-antitoxin (TA) module
TC41_RS02255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TC41_RS02260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TC41_RS02265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TC41_RS02280	COG4844	belongs to the
TC41_RS02290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TC41_RS02295	COG0802	atpase or kinase
TC41_RS02305	COG0456	acetyltransferase
TC41_RS02310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TC41_RS02315	COG0488	(ABC) transporter
TC41_RS02325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TC41_RS02335	COG1058	Belongs to the CinA family
TC41_RS02335	COG1546	Belongs to the CinA family
TC41_RS02340	COG1763	Mo-molybdopterin cofactor biosynthetic process
TC41_RS02345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TC41_RS02380	COG2197	response regulator
TC41_RS02390	COG0714	Associated with various cellular activities
TC41_RS02400	COG1305	Transglutaminase-like
TC41_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_RS02415	COG0519	Catalyzes the synthesis of GMP from XMP
TC41_RS02415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TC41_RS02420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TC41_RS02425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TC41_RS02430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TC41_RS02440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TC41_RS02445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TC41_RS02450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TC41_RS02455	COG0138	bifunctional purine biosynthesis protein purh
TC41_RS02460	COG0151	Belongs to the GarS family
TC41_RS02490	COG2884	Cell division ATP-binding protein ftsE
TC41_RS02495	COG2177	Part of the ABC transporter FtsEX involved in
TC41_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_RS02505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TC41_RS02515	COG0556	nucleotide-excision repair
TC41_RS02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TC41_RS02525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TC41_RS02535	COG4235	cytochrome complex assembly
TC41_RS02545	COG1660	Displays ATPase and GTPase activities
TC41_RS02550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TC41_RS02555	COG1481	regulation of sporulation
TC41_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_RS02585	COG0670	Belongs to the BI1 family
TC41_RS02590	COG0495	leucyl-tRNA aminoacylation
TC41_RS02610	COG0628	permease
TC41_RS02625	COG1111	helicase
TC41_RS02625	COG1205	dead DEAH box helicase
TC41_RS02645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TC41_RS02655	COG0697	spore germination
TC41_RS02670	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS02675	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS02690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_RS02695	COG0328	RNA-DNA hybrid ribonuclease activity
TC41_RS02700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TC41_RS02705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TC41_RS02715	COG0538	isocitrate dehydrogenase activity
TC41_RS02720	COG1414	Transcriptional regulator
TC41_RS02730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TC41_RS02760	COG2272	Belongs to the type-B carboxylesterase lipase family
TC41_RS02765	COG2766	serine protein kinase
TC41_RS02770	COG2718	Belongs to the UPF0229 family
TC41_RS02775	COG2719	SpoVR family
TC41_RS02795	COG2860	membrane
TC41_RS02805	COG2200	EAL domain
TC41_RS02805	COG2199	diguanylate cyclase activity
TC41_RS02815	COG0529	Catalyzes the synthesis of activated sulfate
TC41_RS02830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TC41_RS02835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TC41_RS02845	COG1131	(ABC) transporter
TC41_RS02855	COG1131	(ABC) transporter
TC41_RS02860	COG1725	Transcriptional regulator
TC41_RS02865	COG1234	tRNA 3'-trailer cleavage
TC41_RS02870	COG2814	Major facilitator Superfamily
TC41_RS02875	COG1846	Transcriptional regulator
TC41_RS02885	COG1131	(ABC) transporter
TC41_RS02890	COG0842	Transport permease protein
TC41_RS02900	COG2197	response regulator
TC41_RS02925	COG1845	cytochrome c oxidase, subunit III
TC41_RS02930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TC41_RS02935	COG1612	heme a metabolic process
TC41_RS02940	COG1686	Belongs to the peptidase S11 family
TC41_RS02960	COG0667	Aldo Keto reductase
TC41_RS02965	COG1454	alcohol dehydrogenase
TC41_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS02985	COG0745	RESPONSE REGULATOR receiver
TC41_RS02990	COG5002	protein histidine kinase activity
TC41_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS03020	COG3384	dioxygenase
TC41_RS03030	COG0454	-acetyltransferase
TC41_RS03035	COG0210	DNA helicase
TC41_RS03040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TC41_RS03050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TC41_RS03055	COG0154	amidase activity
TC41_RS03060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TC41_RS03065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TC41_RS03070	COG1073	alpha beta
TC41_RS03105	COG3263	regulation of cellular component size
TC41_RS03115	COG1070	Carbohydrate kinase
TC41_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS03120	COG3347	Dehydrogenase
TC41_RS03130	COG1069	ribulokinase activity
TC41_RS03140	COG1172	Belongs to the binding-protein-dependent transport system permease family
TC41_RS03165	COG1349	DNA-binding transcription factor activity
TC41_RS03180	COG0247	lactate metabolic process
TC41_RS03190	COG2323	membrane
TC41_RS03210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TC41_RS03210	COG2755	lipolytic protein G-D-S-L family
TC41_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS03240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TC41_RS03245	COG2271	Major facilitator Superfamily
TC41_RS03250	COG2155	Conserved Protein
TC41_RS03255	COG0019	diaminopimelate decarboxylase activity
TC41_RS03270	COG1914	H( )-stimulated, divalent metal cation uptake system
TC41_RS03285	COG1164	Oligoendopeptidase f
TC41_RS03290	COG5002	protein histidine kinase activity
TC41_RS03300	COG0126	phosphoglycerate kinase activity
TC41_RS03305	COG0149	triose-phosphate isomerase activity
TC41_RS03315	COG0148	phosphopyruvate hydratase activity
TC41_RS03320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TC41_RS03325	COG2807	transmembrane transport
TC41_RS03330	COG0557	exoribonuclease II activity
TC41_RS03335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TC41_RS03340	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS03345	COG5609	conserved protein (DUF2294)
TC41_RS03385	COG2226	methyltransferase
TC41_RS03400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TC41_RS03405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TC41_RS03420	COG3665	Urea carboxylase-associated protein
TC41_RS03425	COG0439	Biotin carboxylase
TC41_RS03435	COG0395	ABC-type sugar transport system, permease component
TC41_RS03440	COG1175	transmembrane transport
TC41_RS03480	COG0681	Belongs to the peptidase S26 family
TC41_RS03485	COG0667	Aldo Keto reductase
TC41_RS03490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TC41_RS03515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TC41_RS03525	COG0673	inositol 2-dehydrogenase activity
TC41_RS03530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TC41_RS03545	COG3459	Glycosyltransferase 36 associated
TC41_RS03550	COG2814	Major facilitator Superfamily
TC41_RS03560	COG2079	MmgE PrpD family protein
TC41_RS03565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TC41_RS03570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TC41_RS03580	COG0542	response to heat
TC41_RS03605	COG0477	Major facilitator Superfamily
TC41_RS03610	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS03615	COG1454	alcohol dehydrogenase
TC41_RS03620	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS03635	COG1691	(AIR) carboxylase
TC41_RS03660	COG1058	Belongs to the CinA family
TC41_RS03660	COG1546	Belongs to the CinA family
TC41_RS03675	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TC41_RS03685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TC41_RS03690	COG1309	transcriptional regulator
TC41_RS03695	COG3396	Phenylacetate-CoA oxygenase
TC41_RS03710	COG2151	metal-sulfur cluster biosynthetic enzyme
TC41_RS03715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TC41_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS03735	COG1024	Enoyl-CoA hydratase
TC41_RS03755	COG1346	cytolysis
TC41_RS03760	COG1380	Effector of murein hydrolase LrgA
TC41_RS03765	COG0583	DNA-binding transcription factor activity
TC41_RS03775	COG2808	Putative FMN-binding domain
TC41_RS03780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TC41_RS03800	COG1024	Enoyl-CoA hydratase
TC41_RS03805	COG2962	Rard protein
TC41_RS03825	COG1132	(ABC) transporter
TC41_RS03835	COG0604	alcohol dehydrogenase
TC41_RS03850	COG1132	(ABC) transporter
TC41_RS03865	COG5609	conserved protein (DUF2294)
TC41_RS03870	COG2116	formate transmembrane transporter activity
TC41_RS03875	COG3383	formate dehydrogenase (NAD+) activity
TC41_RS03885	COG1252	NADH dehydrogenase
TC41_RS03895	COG0656	L-ascorbic acid biosynthetic process
TC41_RS03910	COG3069	C4-dicarboxylate transmembrane transporter activity
TC41_RS03915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_RS03920	COG2814	Major facilitator Superfamily
TC41_RS03945	COG0561	phosphatase activity
TC41_RS03965	COG0519	Catalyzes the synthesis of GMP from XMP
TC41_RS03975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TC41_RS03980	COG1119	ATPase activity
TC41_RS03985	COG2353	YceI-like domain
TC41_RS03990	COG1733	regulation of RNA biosynthetic process
TC41_RS04000	COG2046	Belongs to the sulfate adenylyltransferase family
TC41_RS04005	COG1846	Transcriptional regulator
TC41_RS04010	COG3361	conserved protein (COG2071)
TC41_RS04015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_RS04020	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS04025	COG0667	Aldo Keto reductase
TC41_RS04030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TC41_RS04035	COG1335	isochorismatase
TC41_RS04050	COG2814	Major facilitator Superfamily
TC41_RS04055	COG3973	AAA domain
TC41_RS04060	COG2207	Transcriptional regulator
TC41_RS04065	COG0477	Major facilitator Superfamily
TC41_RS04080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_RS04090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TC41_RS04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TC41_RS04120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_RS04120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TC41_RS04120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TC41_RS04125	COG1349	DNA-binding transcription factor activity
TC41_RS04130	COG1105	Belongs to the carbohydrate kinase PfkB family
TC41_RS04145	COG0154	amidase activity
TC41_RS04160	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
TC41_RS04165	COG0640	Transcriptional regulator
TC41_RS04180	COG0626	cystathionine gamma-synthase activity
TC41_RS04200	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS04210	COG0424	maF-like protein
TC41_RS04220	COG2081	HI0933 family
TC41_RS04230	COG1979	alcohol dehydrogenase
TC41_RS04250	COG1175	transmembrane transport
TC41_RS04255	COG0395	ABC-type sugar transport system, permease component
TC41_RS04260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TC41_RS04265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TC41_RS04270	COG0109	protoheme IX farnesyltransferase activity
TC41_RS04285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TC41_RS04290	COG2823	Periplasmic or secreted lipoprotein
TC41_RS04290	COG1652	LysM domain
TC41_RS04295	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TC41_RS04300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TC41_RS04305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TC41_RS04310	COG0131	Imidazoleglycerol-phosphate dehydratase
TC41_RS04315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TC41_RS04320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TC41_RS04325	COG0107	imidazoleglycerol-phosphate synthase activity
TC41_RS04330	COG0140	phosphoribosyl-ATP diphosphatase activity
TC41_RS04330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TC41_RS04350	COG0604	alcohol dehydrogenase
TC41_RS04360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TC41_RS04360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TC41_RS04370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TC41_RS04370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TC41_RS04375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TC41_RS04385	COG4721	ABC-type cobalt transport system, permease component
TC41_RS04390	COG1122	ATPase activity
TC41_RS04410	COG0482	sulfurtransferase activity
TC41_RS04445	COG1960	acyl-CoA dehydrogenase activity
TC41_RS04455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TC41_RS04485	COG0564	pseudouridine synthase activity
TC41_RS04490	COG1295	ribonuclease BN
TC41_RS04495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TC41_RS04510	COG1160	GTP binding
TC41_RS04515	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TC41_RS04530	COG0586	Pfam SNARE associated Golgi protein
TC41_RS04555	COG0302	gtp cyclohydrolase
TC41_RS04560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TC41_RS04575	COG0167	dihydroorotate dehydrogenase activity
TC41_RS04590	COG0686	Belongs to the AlaDH PNT family
TC41_RS04595	COG2151	metal-sulfur cluster biosynthetic enzyme
TC41_RS04600	COG0396	ATPase activity
TC41_RS04605	COG0719	Fe-S assembly protein
TC41_RS04610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TC41_RS04615	COG0822	iron-sulfur transferase activity
TC41_RS04620	COG0719	Fe-S assembly protein
TC41_RS04630	COG1959	2 iron, 2 sulfur cluster binding
TC41_RS04650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TC41_RS04655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TC41_RS04670	COG0531	amino acid
TC41_RS04695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_RS04715	COG0587	DNA-directed DNA polymerase activity
TC41_RS04725	COG0671	phosphoesterase, PA-phosphatase related
TC41_RS04740	COG0537	adenosine 5'-monophosphoramidase activity
TC41_RS04755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TC41_RS04765	COG0612	Peptidase, M16
TC41_RS04770	COG0612	Peptidase, M16
TC41_RS04780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TC41_RS04785	COG0083	homoserine kinase activity
TC41_RS04790	COG2050	protein possibly involved in aromatic compounds catabolism
TC41_RS04815	COG4372	Transposase
TC41_RS04880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TC41_RS04890	COG0772	Belongs to the SEDS family
TC41_RS04900	COG0584	glycerophosphoryl diester phosphodiesterase
TC41_RS04905	COG0772	Belongs to the SEDS family
TC41_RS04910	COG0436	Aminotransferase
TC41_RS04930	COG1982	Orn Lys Arg decarboxylase major
TC41_RS04935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TC41_RS04940	COG0316	Belongs to the HesB IscA family
TC41_RS04945	COG1078	dGTPase activity
TC41_RS04950	COG0586	Pfam SNARE associated Golgi protein
TC41_RS04955	COG3377	Domain of unknown function (DUF1805)
TC41_RS04960	COG1363	Peptidase, m42
TC41_RS04965	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TC41_RS04970	COG0494	nUDIX hydrolase
TC41_RS04980	COG3584	3D domain protein
TC41_RS04980	COG1388	LysM domain
TC41_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS05035	COG2070	2-Nitropropane dioxygenase
TC41_RS05040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TC41_RS05105	COG0395	ABC-type sugar transport system, permease component
TC41_RS05110	COG3250	beta-galactosidase activity
TC41_RS05125	COG4372	Transposase
TC41_RS05130	COG2801	Transposase and inactivated derivatives
TC41_RS05140	COG1960	acyl-CoA dehydrogenase activity
TC41_RS05145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TC41_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS05170	COG1609	Transcriptional regulator
TC41_RS05185	COG0512	Glutamine amidotransferase of anthranilate synthase
TC41_RS05205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TC41_RS05210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TC41_RS05215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TC41_RS05230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TC41_RS05235	COG0137	argininosuccinate synthase activity
TC41_RS05240	COG0165	Argininosuccinate lyase
TC41_RS05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TC41_RS05260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TC41_RS05305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_RS05355	COG1725	Transcriptional regulator
TC41_RS05360	COG1131	(ABC) transporter
TC41_RS05380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_RS05410	COG1802	Transcriptional regulator
TC41_RS05415	COG1584	GPR1 FUN34 yaaH family protein
TC41_RS05420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_RS05425	COG3906	Belongs to the UPF0473 family
TC41_RS05450	COG0740	serine-type endopeptidase activity
TC41_RS05455	COG1104	cysteine desulfurase activity
TC41_RS05460	COG0301	tRNA thio-modification
TC41_RS05480	COG0300	oxidoreductase activity
TC41_RS05485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TC41_RS05490	COG2001	Belongs to the MraZ family
TC41_RS05495	COG0275	rRNA processing
TC41_RS05505	COG0768	penicillin binding
TC41_RS05510	COG0768	penicillin binding
TC41_RS05515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TC41_RS05520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TC41_RS05525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TC41_RS05530	COG0772	Belongs to the SEDS family
TC41_RS05535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_RS05540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TC41_RS05545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_RS05550	COG0492	ferredoxin-NADP+ reductase activity
TC41_RS05555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TC41_RS05560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_RS05580	COG3856	small basic protein
TC41_RS05585	COG0849	cell division
TC41_RS05590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TC41_RS05615	COG1191	sigma factor activity
TC41_RS05620	COG1191	sigma factor activity
TC41_RS05625	COG1873	PFAM PRC-barrel domain
TC41_RS05635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TC41_RS05650	COG3599	regulation of cell shape
TC41_RS05670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TC41_RS05675	COG0564	pseudouridine synthase activity
TC41_RS05685	COG0540	Belongs to the ATCase OTCase family
TC41_RS05690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TC41_RS05705	COG0284	orotidine-5'-phosphate decarboxylase activity
TC41_RS05710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TC41_RS05715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TC41_RS05715	COG0723	plastoquinol--plastocyanin reductase activity
TC41_RS05725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TC41_RS05735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TC41_RS05740	COG1561	YicC-like family, N-terminal region
TC41_RS05750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TC41_RS05755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TC41_RS05760	COG0242	peptide deformylase activity
TC41_RS05765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TC41_RS05770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TC41_RS05770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TC41_RS05775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TC41_RS05780	COG0631	protein serine/threonine phosphatase activity
TC41_RS05785	COG0515	serine threonine protein kinase
TC41_RS05785	COG2815	serine threonine protein kinase
TC41_RS05790	COG1162	GTPase activity
TC41_RS05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TC41_RS05805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TC41_RS05810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TC41_RS05820	COG0688	phosphatidylethanolamine metabolic process
TC41_RS05835	COG0154	amidase activity
TC41_RS05840	COG0742	ribosomal rna small subunit methyltransferase
TC41_RS05845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TC41_RS05850	COG1752	Esterase of the alpha-beta hydrolase superfamily
TC41_RS05865	COG0416	fatty acid biosynthetic process
TC41_RS05870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TC41_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS05880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TC41_RS05885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TC41_RS05890	COG0571	ribonuclease III activity
TC41_RS05895	COG1196	nuclear chromosome segregation
TC41_RS05900	COG0552	protein localization to endoplasmic reticulum
TC41_RS05905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TC41_RS05910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TC41_RS05915	COG0228	four-way junction DNA binding
TC41_RS05920	COG1837	Belongs to the UPF0109 family
TC41_RS05935	COG0336	Belongs to the RNA methyltransferase TrmD family
TC41_RS05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TC41_RS05960	COG0564	pseudouridine synthase activity
TC41_RS05970	COG0739	heme binding
TC41_RS05975	COG1607	acyl-coa hydrolase
TC41_RS05995	COG0335	large ribosomal subunit rRNA binding
TC41_RS06005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TC41_RS06035	COG0045	succinate-CoA ligase (ADP-forming) activity
TC41_RS06040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TC41_RS06045	COG0758	DNA mediated transformation
TC41_RS06045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TC41_RS06065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TC41_RS06070	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TC41_RS06075	COG4974	Belongs to the 'phage' integrase family
TC41_RS06085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TC41_RS06100	COG1677	Flagellar hook-basal body complex protein FliE
TC41_RS06105	COG1766	The M ring may be actively involved in energy transduction
TC41_RS06110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_RS06120	COG1157	protein secretion by the type III secretion system
TC41_RS06155	COG1749	Flagellar hook protein flgE
TC41_RS06170	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_RS06175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TC41_RS06175	COG1776	CheC inhibitor of MCP methylation
TC41_RS06180	COG2201	protein-glutamate methylesterase activity
TC41_RS06185	COG3190	flagellar
TC41_RS06190	COG1338	Plays a role in the flagellum-specific transport system
TC41_RS06195	COG1987	bacterial-type flagellum assembly
TC41_RS06205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TC41_RS06210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TC41_RS06215	COG1419	protein localization to endoplasmic reticulum
TC41_RS06230	COG0643	Histidine kinase
TC41_RS06230	COG2198	Histidine kinase
TC41_RS06235	COG0835	chemotaxis
TC41_RS06240	COG1776	CheC inhibitor of MCP methylation
TC41_RS06245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TC41_RS06265	COG0052	Belongs to the universal ribosomal protein uS2 family
TC41_RS06270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TC41_RS06275	COG0528	UMP kinase activity
TC41_RS06280	COG0233	cytoplasmic translational termination
TC41_RS06285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TC41_RS06290	COG4589	Belongs to the CDS family
TC41_RS06295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TC41_RS06305	COG2176	DNA-directed DNA polymerase activity
TC41_RS06310	COG0346	lactoylglutathione lyase activity
TC41_RS06315	COG0077	Prephenate dehydratase
TC41_RS06320	COG1217	gtp-binding protein TYPA
TC41_RS06325	COG0779	Required for maturation of 30S ribosomal subunits
TC41_RS06330	COG0195	Participates in both transcription termination and antitermination
TC41_RS06335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TC41_RS06345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TC41_RS06350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TC41_RS06355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TC41_RS06360	COG0196	riboflavin kinase activity
TC41_RS06370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TC41_RS06375	COG1185	polyribonucleotide nucleotidyltransferase activity
TC41_RS06385	COG0612	Peptidase, M16
TC41_RS06395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TC41_RS06400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TC41_RS06405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TC41_RS06410	COG0527	aspartate kinase activity
TC41_RS06425	COG1960	acyl-CoA dehydrogenase activity
TC41_RS06435	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS06440	COG1024	Enoyl-CoA hydratase
TC41_RS06445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_RS06450	COG0183	Belongs to the thiolase family
TC41_RS06465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TC41_RS06470	COG0740	serine-type endopeptidase activity
TC41_RS06480	COG4980	gas vesicle protein
TC41_RS06480	COG1674	ftsk spoiiie
TC41_RS06505	COG1426	Protein conserved in bacteria
TC41_RS06510	COG1666	GTP binding
TC41_RS06515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TC41_RS06520	COG1058	Belongs to the CinA family
TC41_RS06520	COG1546	Belongs to the CinA family
TC41_RS06525	COG0513	Belongs to the DEAD box helicase family
TC41_RS06530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TC41_RS06540	COG1418	mRNA catabolic process
TC41_RS06545	COG2359	stage V sporulation protein S
TC41_RS06575	COG0189	ligase activity
TC41_RS06585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TC41_RS06595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TC41_RS06600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TC41_RS06605	COG2521	methyltransferase
TC41_RS06605	COG2136	Putative SAM-dependent methyltransferase
TC41_RS06610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TC41_RS06615	COG1923	regulation of RNA biosynthetic process
TC41_RS06675	COG0473	3-isopropylmalate dehydrogenase activity
TC41_RS06680	COG0697	spore germination
TC41_RS06700	COG0697	spore germination
TC41_RS06705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TC41_RS06710	COG2244	polysaccharide biosynthetic process
TC41_RS06720	COG0464	growth
TC41_RS06740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TC41_RS06745	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TC41_RS06750	COG0789	Transcriptional regulator
TC41_RS06755	COG0174	glutamine synthetase
TC41_RS06765	COG2721	sulfolactate sulfo-lyase activity
TC41_RS06770	COG3718	enzyme involved in inositol metabolism
TC41_RS06775	COG0246	Mannitol dehydrogenase
TC41_RS06780	COG2814	Major facilitator Superfamily
TC41_RS06785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TC41_RS06790	COG0561	phosphatase activity
TC41_RS06795	COG0423	glycine-tRNA ligase activity
TC41_RS06805	COG0646	methionine synthase
TC41_RS06805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TC41_RS06815	COG3706	GGDEF domain
TC41_RS06840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TC41_RS06845	COG2086	electron transfer activity
TC41_RS06850	COG1309	transcriptional regulator
TC41_RS06855	COG0247	lactate metabolic process
TC41_RS06855	COG2181	nitrate reductase activity
TC41_RS06860	COG1024	Enoyl-CoA hydratase
TC41_RS06860	COG1250	3-hydroxyacyl-CoA dehydrogenase
TC41_RS06865	COG0183	Belongs to the thiolase family
TC41_RS06870	COG1960	acyl-CoA dehydrogenase activity
TC41_RS06875	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS06885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_RS06890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TC41_RS06895	COG0531	amino acid
TC41_RS06900	COG1289	transmembrane transporter activity
TC41_RS06920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TC41_RS06925	COG0517	IMP dehydrogenase activity
TC41_RS06925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TC41_RS06930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TC41_RS06930	COG0574	Belongs to the PEP-utilizing enzyme family
TC41_RS06935	COG1494	fructose-1,6-bisphosphatase
TC41_RS06950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_RS06975	COG1942	4-Oxalocrotonate Tautomerase
TC41_RS07010	COG1414	Transcriptional regulator
TC41_RS07025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TC41_RS07030	COG0174	glutamine synthetase
TC41_RS07035	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TC41_RS07040	COG0445	tRNA wobble uridine modification
TC41_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TC41_RS07065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TC41_RS07070	COG1181	Belongs to the D-alanine--D-alanine ligase family
TC41_RS07075	COG3935	DnaD domain protein
TC41_RS07080	COG0017	Asparaginyl-tRNA synthetase
TC41_RS07085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TC41_RS07105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TC41_RS07110	COG0402	S-adenosylhomocysteine deaminase activity
TC41_RS07115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TC41_RS07120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TC41_RS07135	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TC41_RS07140	COG1199	ATP-dependent helicase activity
TC41_RS07140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_RS07155	COG0617	tRNA 3'-terminal CCA addition
TC41_RS07160	COG0438	transferase activity, transferring glycosyl groups
TC41_RS07165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TC41_RS07170	COG1694	Mazg nucleotide pyrophosphohydrolase
TC41_RS07180	COG1968	undecaprenyl-diphosphatase activity
TC41_RS07185	COG3949	Membrane
TC41_RS07190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TC41_RS07205	COG0287	Prephenate dehydrogenase
TC41_RS07210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TC41_RS07215	COG0159	tryptophan synthase activity
TC41_RS07220	COG0133	tryptophan synthase activity
TC41_RS07225	COG0135	phosphoribosylanthranilate isomerase activity
TC41_RS07230	COG0134	indole-3-glycerol-phosphate synthase activity
TC41_RS07235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TC41_RS07240	COG4401	Chorismate mutase type I
TC41_RS07245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TC41_RS07250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TC41_RS07265	COG1363	Peptidase, m42
TC41_RS07270	COG0564	pseudouridine synthase activity
TC41_RS07280	COG0791	NLP P60 protein
TC41_RS07280	COG1388	LysM domain
TC41_RS07290	COG0714	Associated with various cellular activities
TC41_RS07295	COG0508	dehydrogenase complex catalyzes the overall conversion of
TC41_RS07300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TC41_RS07305	COG0517	IMP dehydrogenase activity
TC41_RS07315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TC41_RS07325	COG0105	UTP biosynthetic process
TC41_RS07330	COG0142	geranyltranstransferase activity
TC41_RS07335	COG2226	methyltransferase
TC41_RS07355	COG1064	alcohol dehydrogenase
TC41_RS07360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TC41_RS07375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TC41_RS07380	COG1160	GTP binding
TC41_RS07390	COG0539	negative regulation of cytoplasmic translation
TC41_RS07410	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TC41_RS07430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TC41_RS07435	COG4862	establishment of competence for transformation
TC41_RS07440	COG1609	Transcriptional regulator
TC41_RS07465	COG0210	DNA helicase
TC41_RS07465	COG0210	DNA helicase
TC41_RS07485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_RS07495	COG2339	peptidase activity
TC41_RS07505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TC41_RS07520	COG5002	protein histidine kinase activity
TC41_RS07525	COG0745	RESPONSE REGULATOR receiver
TC41_RS07535	COG1187	pseudouridine synthase activity
TC41_RS07540	COG0700	Nucleoside recognition
TC41_RS07545	COG2715	membrane protein required for spore maturation
TC41_RS07550	COG3874	Sporulation protein YtfJ
TC41_RS07560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TC41_RS07565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TC41_RS07570	COG1994	Peptidase M50
TC41_RS07590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TC41_RS07600	COG1191	sigma factor activity
TC41_RS07605	COG2172	sigma factor antagonist activity
TC41_RS07610	COG1366	Belongs to the anti-sigma-factor antagonist family
TC41_RS07620	COG1686	Belongs to the peptidase S11 family
TC41_RS07625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TC41_RS07630	COG4974	Belongs to the 'phage' integrase family
TC41_RS07645	COG1379	DNA repair
TC41_RS07650	COG0494	nUDIX hydrolase
TC41_RS07655	COG2195	Cleaves the N-terminal amino acid of tripeptides
TC41_RS07660	COG0321	lipoyl(octanoyl) transferase activity
TC41_RS07665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TC41_RS07680	COG3858	chitin binding
TC41_RS07680	COG1388	LysM domain
TC41_RS07720	COG0750	zinc metalloprotease
TC41_RS07725	COG0497	DNA recombination
TC41_RS07730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TC41_RS07740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TC41_RS07760	COG1570	exodeoxyribonuclease VII activity
TC41_RS07765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TC41_RS07770	COG0492	ferredoxin-NADP+ reductase activity
TC41_RS07800	COG0439	Biotin carboxylase
TC41_RS07805	COG0511	ligase activity, forming carbon-carbon bonds
TC41_RS07845	COG3854	ATPases associated with a variety of cellular activities
TC41_RS07850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TC41_RS07855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TC41_RS07860	COG0406	alpha-ribazole phosphatase activity
TC41_RS07865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TC41_RS07870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TC41_RS07875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TC41_RS07880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TC41_RS07890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TC41_RS07895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TC41_RS07900	COG2002	toxin-antitoxin pair type II binding
TC41_RS07955	COG1192	Involved in chromosome partitioning
TC41_RS07965	COG2200	EAL domain
TC41_RS08095	COG1988	membrane-bound metal-dependent
TC41_RS08100	COG3617	BRO family, N-terminal domain
TC41_RS08105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TC41_RS08185	COG1475	DNA binding
TC41_RS08215	COG1475	DNA binding
TC41_RS08255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_RS08295	COG2433	Pfam Transposase IS66
TC41_RS08300	COG0640	Transcriptional regulator
TC41_RS08315	COG0346	lactoylglutathione lyase activity
TC41_RS08380	COG4372	Transposase
TC41_RS08385	COG4372	Transposase
TC41_RS08425	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_RS08445	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS08455	COG1024	Enoyl-CoA hydratase
TC41_RS08485	COG4372	Transposase
TC41_RS08515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_RS08595	COG0592	DNA-directed DNA polymerase activity
TC41_RS08690	COG1396	sequence-specific DNA binding
TC41_RS08735	COG1459	type II secretion system
TC41_RS08750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TC41_RS08760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TC41_RS08765	COG2868	ribosomal protein
TC41_RS08775	COG1994	Peptidase M50
TC41_RS08785	COG2894	cell division
TC41_RS08790	COG0850	regulation of cytokinetic process
TC41_RS08805	COG1077	Cell shape determining protein MreB Mrl
TC41_RS08810	COG2003	Belongs to the UPF0758 family
TC41_RS08825	COG3584	3D domain protein
TC41_RS08825	COG3583	domain protein
TC41_RS08830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TC41_RS08835	COG0285	dihydrofolate synthase activity
TC41_RS08840	COG0525	valine-tRNA ligase activity
TC41_RS08855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TC41_RS08860	COG0113	porphobilinogen synthase activity
TC41_RS08870	COG0181	hydroxymethylbilane synthase activity
TC41_RS08880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TC41_RS08885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TC41_RS08890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TC41_RS08895	COG1067	ATP-dependent peptidase activity
TC41_RS08895	COG0470	DNA polymerase III
TC41_RS08900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TC41_RS08905	COG0740	serine-type endopeptidase activity
TC41_RS08910	COG0544	peptidyl-prolyl cis-trans isomerase activity
TC41_RS08925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TC41_RS08930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TC41_RS08935	COG1846	Transcriptional regulator
TC41_RS08940	COG1960	acyl-CoA dehydrogenase activity
TC41_RS08945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TC41_RS08960	COG2197	response regulator
TC41_RS08965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TC41_RS08975	COG2188	Transcriptional regulator
TC41_RS08980	COG2814	Major facilitator Superfamily
TC41_RS08985	COG1054	Belongs to the UPF0176 family
TC41_RS08995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TC41_RS09000	COG1053	succinate dehydrogenase
TC41_RS09005	COG2009	succinate dehydrogenase
TC41_RS09010	COG0322	excinuclease ABC activity
TC41_RS09035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_RS09045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TC41_RS09055	COG0387	Pfam Sodium calcium exchanger
TC41_RS09085	COG0463	Glycosyl transferase, family 2
TC41_RS09095	COG1846	Transcriptional regulator
TC41_RS09110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TC41_RS09115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TC41_RS09135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TC41_RS09140	COG0647	UMP catabolic process
TC41_RS09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_RS09160	COG2076	Multidrug Resistance protein
TC41_RS09165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TC41_RS09180	COG2723	6-phospho-beta-galactosidase activity
TC41_RS09185	COG4608	Belongs to the ABC transporter superfamily
TC41_RS09200	COG0601	transmembrane transport
TC41_RS09220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TC41_RS09225	COG0704	Plays a role in the regulation of phosphate uptake
TC41_RS09230	COG1388	LysM domain
TC41_RS09230	COG0791	NLP P60 protein
TC41_RS09235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TC41_RS09240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_RS09255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TC41_RS09285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TC41_RS09295	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS09300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TC41_RS09305	COG1575	Belongs to the MenA family. Type 1 subfamily
TC41_RS09310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TC41_RS09315	COG2427	Protein of unknown function (DUF1641)
TC41_RS09320	COG3383	formate dehydrogenase (NAD+) activity
TC41_RS09325	COG1331	Highly conserved protein containing a thioredoxin domain
TC41_RS09330	COG1331	Highly conserved protein containing a thioredoxin domain
TC41_RS09340	COG0697	spore germination
TC41_RS09350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TC41_RS09355	COG0351	phosphomethylpyrimidine kinase
TC41_RS09360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TC41_RS09365	COG0352	thiamine-phosphate diphosphorylase activity
TC41_RS09380	COG0697	spore germination
TC41_RS09385	COG0069	glutamate synthase activity
TC41_RS09395	COG4988	ABC transporter
TC41_RS09400	COG1294	oxidase, subunit
TC41_RS09405	COG1271	oxidase subunit
TC41_RS09410	COG0477	Major facilitator Superfamily
TC41_RS09415	COG1846	Transcriptional regulator
TC41_RS09425	COG1120	ATPase activity
TC41_RS09430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TC41_RS09435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TC41_RS09455	COG1733	regulation of RNA biosynthetic process
TC41_RS09460	COG0720	synthase
TC41_RS09465	COG0602	queuosine metabolic process
TC41_RS09480	COG0248	Ppx GppA phosphatase
TC41_RS09485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TC41_RS09510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TC41_RS09530	COG0697	spore germination
TC41_RS09550	COG4191	Histidine kinase
TC41_RS09565	COG1902	pentaerythritol trinitrate reductase activity
TC41_RS09570	COG5002	protein histidine kinase activity
TC41_RS09575	COG0745	RESPONSE REGULATOR receiver
TC41_RS09595	COG0010	Belongs to the arginase family
TC41_RS09600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TC41_RS09605	COG2384	SAM-dependent methyltransferase
TC41_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TC41_RS09620	COG0358	DNA primase activity
TC41_RS09625	COG1381	Involved in DNA repair and RecF pathway recombination
TC41_RS09630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TC41_RS09640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TC41_RS09645	COG1480	7TM receptor with intracellular HD hydrolase
TC41_RS09650	COG1702	phosphate starvation-inducible protein PhoH
TC41_RS09665	COG1610	YqeY-like protein
TC41_RS09670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TC41_RS09680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TC41_RS09685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TC41_RS09690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TC41_RS09695	COG2264	protein methyltransferase activity
TC41_RS09700	COG0484	heat shock protein binding
TC41_RS09705	COG0443	Heat shock 70 kDa protein
TC41_RS09710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TC41_RS09715	COG1420	regulation of RNA biosynthetic process
TC41_RS09720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TC41_RS09725	COG0481	GTPase activity
TC41_RS09740	COG0741	lytic transglycosylase activity
TC41_RS09750	COG0268	Binds directly to 16S ribosomal RNA
TC41_RS09765	COG1252	NADH dehydrogenase
TC41_RS09775	COG1555	photosystem II stabilization
TC41_RS09775	COG1596	polysaccharide export
TC41_RS09780	COG1321	iron dependent repressor
TC41_RS09785	COG2226	methyltransferase
TC41_RS09790	COG0799	negative regulation of ribosome biogenesis
TC41_RS09795	COG1713	HD superfamily hydrolase involved in NAD metabolism
TC41_RS09800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TC41_RS09805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TC41_RS09845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TC41_RS09855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TC41_RS09860	COG0628	permease
TC41_RS09870	COG1104	cysteine desulfurase activity
TC41_RS09875	COG1959	2 iron, 2 sulfur cluster binding
TC41_RS09890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TC41_RS09895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TC41_RS09900	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS09905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TC41_RS09910	COG0124	histidyl-tRNA synthetase
TC41_RS09915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TC41_RS09930	COG1131	(ABC) transporter
TC41_RS09940	COG2814	Major facilitator Superfamily
TC41_RS09950	COG1175	transmembrane transport
TC41_RS09970	COG1024	Enoyl-CoA hydratase
TC41_RS09975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TC41_RS09980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TC41_RS09985	COG0511	ligase activity, forming carbon-carbon bonds
TC41_RS09990	COG0439	Biotin carboxylase
TC41_RS09995	COG1960	acyl-CoA dehydrogenase activity
TC41_RS10000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TC41_RS10010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TC41_RS10015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TC41_RS10030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TC41_RS10035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TC41_RS10035	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TC41_RS10040	COG1250	3-hydroxyacyl-CoA dehydrogenase
TC41_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS10055	COG2211	Major facilitator Superfamily
TC41_RS10060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TC41_RS10065	COG0667	Aldo Keto reductase
TC41_RS10075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TC41_RS10085	COG1074	ATP-dependent DNA helicase activity
TC41_RS10090	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TC41_RS10095	COG0477	Major facilitator Superfamily
TC41_RS10100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TC41_RS10115	COG1686	Belongs to the peptidase S11 family
TC41_RS10120	COG1321	iron dependent repressor
TC41_RS10135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TC41_RS10140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TC41_RS10145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TC41_RS10175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TC41_RS10180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_RS10185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TC41_RS10185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TC41_RS10190	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TC41_RS10195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TC41_RS10200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TC41_RS10210	COG2244	polysaccharide biosynthetic process
TC41_RS10215	COG2323	membrane
TC41_RS10220	COG3706	GGDEF domain
TC41_RS10235	COG0343	queuine tRNA-ribosyltransferase activity
TC41_RS10250	COG1191	sigma factor activity
TC41_RS10255	COG2255	four-way junction helicase activity
TC41_RS10260	COG0632	four-way junction helicase activity
TC41_RS10265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TC41_RS10275	COG0217	transcriptional regulatory protein
TC41_RS10285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TC41_RS10285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TC41_RS10305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TC41_RS10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_RS10315	COG1193	negative regulation of DNA recombination
TC41_RS10330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TC41_RS10335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TC41_RS10335	COG0072	phenylalanine-tRNA ligase activity
TC41_RS10340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TC41_RS10345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TC41_RS10350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TC41_RS10355	COG1830	Aldolase
TC41_RS10360	COG0205	6-phosphofructokinase activity
TC41_RS10365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TC41_RS10370	COG0840	transmembrane signaling receptor activity
TC41_RS10375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TC41_RS10380	COG3842	ATPase activity
TC41_RS10395	COG0579	oxidoreductase
TC41_RS10400	COG0508	dehydrogenase complex catalyzes the overall conversion of
TC41_RS10405	COG0567	Dehydrogenase, E1 component
TC41_RS10415	COG0714	Associated with various cellular activities
TC41_RS10430	COG1482	cell wall glycoprotein biosynthetic process
TC41_RS10435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TC41_RS10455	COG0673	inositol 2-dehydrogenase activity
TC41_RS10460	COG1082	Xylose isomerase domain protein TIM barrel
TC41_RS10485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_RS10490	COG0697	spore germination
TC41_RS10495	COG1214	PFAM Peptidase M22, glycoprotease
TC41_RS10495	COG0456	acetyltransferase
TC41_RS10500	COG2267	carboxylic ester hydrolase activity
TC41_RS10505	COG0531	amino acid
TC41_RS10510	COG3546	catalase activity
TC41_RS10525	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TC41_RS10530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_RS10535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TC41_RS10540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TC41_RS10560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TC41_RS10580	COG1070	Carbohydrate kinase
TC41_RS10585	COG2115	Belongs to the xylose isomerase family
TC41_RS10595	COG1408	metallophosphoesterase
TC41_RS10620	COG0300	oxidoreductase activity
TC41_RS10680	COG1278	Cold shock
TC41_RS10695	COG0667	Aldo Keto reductase
TC41_RS10700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TC41_RS10720	COG4989	oxidoreductase activity
TC41_RS10725	COG1082	Xylose isomerase domain protein TIM barrel
TC41_RS10735	COG2154	pterin-4-alpha-carbinolamine dehydratase
TC41_RS10770	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TC41_RS10780	COG0438	transferase activity, transferring glycosyl groups
TC41_RS10790	COG0577	efflux transmembrane transporter activity
TC41_RS10795	COG0577	efflux transmembrane transporter activity
TC41_RS10795	COG1136	(ABC) transporter
TC41_RS10810	COG0517	IMP dehydrogenase activity
TC41_RS10820	COG0372	Belongs to the citrate synthase family
TC41_RS10825	COG1971	Probably functions as a manganese efflux pump
TC41_RS10835	COG0066	3-isopropylmalate dehydratase activity
TC41_RS10840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TC41_RS10845	COG0473	3-isopropylmalate dehydrogenase activity
TC41_RS10850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TC41_RS10855	COG0440	acetolactate synthase activity
TC41_RS10860	COG0028	Belongs to the TPP enzyme family
TC41_RS10865	COG0129	dihydroxy-acid dehydratase activity
TC41_RS10875	COG0460	homoserine dehydrogenase
TC41_RS10895	COG1653	transport
TC41_RS10920	COG0450	alkyl hydroperoxide reductase
TC41_RS10950	COG2002	toxin-antitoxin pair type II binding
TC41_RS11015	COG2200	EAL domain
TC41_RS11100	COG3437	response regulator, receiver
TC41_RS11145	COG3617	BRO family, N-terminal domain
TC41_RS11200	COG0750	zinc metalloprotease
TC41_RS11255	COG1475	DNA binding
TC41_RS11330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_RS11345	COG0750	zinc metalloprotease
TC41_RS11360	COG2361	Protein of unknown function DUF86
TC41_RS11375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TC41_RS11415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TC41_RS11435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TC41_RS11445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TC41_RS11480	COG0592	DNA-directed DNA polymerase activity
TC41_RS11520	COG3617	BRO family, N-terminal domain
TC41_RS11605	COG3858	chitin binding
TC41_RS11605	COG1388	LysM domain
TC41_RS11610	COG0833	amino acid
TC41_RS11640	COG1132	(ABC) transporter
TC41_RS11645	COG1132	(ABC) transporter
TC41_RS11660	COG0747	negative chemotaxis
TC41_RS11665	COG0601	transmembrane transport
TC41_RS11670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TC41_RS11675	COG0747	negative chemotaxis
TC41_RS11680	COG4608	Belongs to the ABC transporter superfamily
TC41_RS11685	COG0444	Belongs to the ABC transporter superfamily
TC41_RS11690	COG0745	RESPONSE REGULATOR receiver
TC41_RS11700	COG0095	Lipoate-protein ligase
TC41_RS11705	COG5002	protein histidine kinase activity
TC41_RS11710	COG0745	RESPONSE REGULATOR receiver
TC41_RS11715	COG0583	DNA-binding transcription factor activity
TC41_RS11725	COG2972	Histidine kinase
TC41_RS11745	COG2207	Transcriptional regulator
TC41_RS11745	COG4753	response regulator
TC41_RS11755	COG1172	Belongs to the binding-protein-dependent transport system permease family
TC41_RS11760	COG1129	ABC transporter
TC41_RS11765	COG0708	Exodeoxyribonuclease III
TC41_RS11790	COG1072	(Pantothenic acid kinase))
TC41_RS11795	COG1132	(ABC) transporter
TC41_RS11800	COG1132	(ABC) transporter
TC41_RS11815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TC41_RS11825	COG0483	inositol monophosphate 1-phosphatase activity
TC41_RS11830	COG1312	Catalyzes the dehydration of D-mannonate
TC41_RS11835	COG0352	thiamine-phosphate diphosphorylase activity
TC41_RS11845	COG1929	Belongs to the glycerate kinase type-1 family
TC41_RS11895	COG2814	Major facilitator Superfamily
TC41_RS11910	COG0840	transmembrane signaling receptor activity
TC41_RS11950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TC41_RS11965	COG2814	Major facilitator Superfamily
TC41_RS11985	COG1349	DNA-binding transcription factor activity
TC41_RS11990	COG1085	galactose-1-phosphate uridylyltransferase
TC41_RS11995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TC41_RS12020	COG1063	alcohol dehydrogenase
TC41_RS12030	COG0768	penicillin binding
TC41_RS12060	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TC41_RS12080	COG1827	regulation of RNA biosynthetic process
TC41_RS12095	COG0237	dephospho-CoA kinase activity
TC41_RS12100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TC41_RS12110	COG1605	Chorismate mutase
TC41_RS12110	COG0077	Prephenate dehydratase
TC41_RS12120	COG0538	isocitrate dehydrogenase activity
TC41_RS12130	COG0745	RESPONSE REGULATOR receiver
TC41_RS12135	COG0180	Tryptophanyl-tRNA synthetase
TC41_RS12140	COG0469	pyruvate kinase activity
TC41_RS12145	COG0825	malonyl-CoA metabolic process
TC41_RS12150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TC41_RS12160	COG0587	DNA-directed DNA polymerase activity
TC41_RS12165	COG4109	DRTGG domain
TC41_RS12190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TC41_RS12195	COG1438	arginine binding
TC41_RS12200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TC41_RS12230	COG3679	Belongs to the UPF0342 family
TC41_RS12235	COG2346	COG2346, Truncated hemoglobins
TC41_RS12260	COG2267	carboxylic ester hydrolase activity
TC41_RS12265	COG1045	serine acetyltransferase
TC41_RS12270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TC41_RS12280	COG4496	protein, YerC YecD
TC41_RS12290	COG2132	Multicopper oxidase
TC41_RS12305	COG1396	sequence-specific DNA binding
TC41_RS12335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TC41_RS12355	COG1063	alcohol dehydrogenase
TC41_RS12360	COG1960	acyl-CoA dehydrogenase activity
TC41_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS12370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TC41_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS12380	COG1902	pentaerythritol trinitrate reductase activity
TC41_RS12380	COG0446	pyridine nucleotide-disulphide oxidoreductase
TC41_RS12385	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS12390	COG1960	acyl-CoA dehydrogenase activity
TC41_RS12395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TC41_RS12405	COG1376	ErfK ybiS ycfS ynhG family protein
TC41_RS12435	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS12440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TC41_RS12450	COG0667	Aldo Keto reductase
TC41_RS12460	COG0840	transmembrane signaling receptor activity
TC41_RS12470	COG0788	formyltetrahydrofolate deformylase activity
TC41_RS12485	COG1587	Uroporphyrinogen-III synthase
TC41_RS12485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TC41_RS12490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TC41_RS12495	COG0175	sulfate reduction
TC41_RS12500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TC41_RS12500	COG1648	precorrin-2 dehydrogenase activity
TC41_RS12510	COG0463	Glycosyl transferase, family 2
TC41_RS12515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TC41_RS12520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TC41_RS12525	COG2814	Major facilitator Superfamily
TC41_RS12530	COG1566	PFAM secretion protein HlyD family protein
TC41_RS12535	COG0768	penicillin binding
TC41_RS12540	COG1215	transferase activity, transferring glycosyl groups
TC41_RS12545	COG0791	NLP P60 protein
TC41_RS12545	COG1388	LysM domain
TC41_RS12545	COG3103	Sh3 type 3 domain protein
TC41_RS12550	COG1809	phosphosulfolactate synthase activity
TC41_RS12560	COG0531	amino acid
TC41_RS12575	COG0697	spore germination
TC41_RS12580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_RS12595	COG1562	ergosterol biosynthetic process
TC41_RS12600	COG1657	PFAM Prenyltransferase squalene oxidase
TC41_RS12605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TC41_RS12615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TC41_RS12620	COG1304	FMN binding
TC41_RS12625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TC41_RS12660	COG2132	Multicopper oxidase
TC41_RS12665	COG2132	Multicopper oxidase
TC41_RS12675	COG0395	ABC-type sugar transport system, permease component
TC41_RS12680	COG1175	transmembrane transport
TC41_RS12695	COG0673	inositol 2-dehydrogenase activity
TC41_RS12700	COG1609	Transcriptional regulator
TC41_RS12720	COG0174	glutamine synthetase
TC41_RS12725	COG0004	ammonium transporteR
TC41_RS12730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TC41_RS12745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TC41_RS12750	COG0601	transmembrane transport
TC41_RS12755	COG4166	transmembrane transport
TC41_RS12765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TC41_RS12770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TC41_RS12785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TC41_RS12790	COG2022	thiamine diphosphate biosynthetic process
TC41_RS12800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TC41_RS12805	COG0352	thiamine-phosphate diphosphorylase activity
TC41_RS12810	COG1227	inorganic diphosphatase activity
TC41_RS12820	COG2814	Major facilitator Superfamily
TC41_RS12835	COG0789	Transcriptional regulator
TC41_RS12855	COG1090	epimerase
TC41_RS12860	COG2271	Major facilitator Superfamily
TC41_RS12880	COG1215	transferase activity, transferring glycosyl groups
TC41_RS12910	COG0693	protein deglycase activity
TC41_RS12920	COG0840	transmembrane signaling receptor activity
TC41_RS12925	COG0531	amino acid
TC41_RS12935	COG1012	belongs to the aldehyde dehydrogenase family
TC41_RS12955	COG0463	Glycosyl transferase, family 2
TC41_RS12955	COG0457	Tetratricopeptide repeat
TC41_RS12965	COG0583	DNA-binding transcription factor activity
TC41_RS12975	COG2271	Major facilitator Superfamily
TC41_RS12985	COG1063	alcohol dehydrogenase
TC41_RS12995	COG0450	alkyl hydroperoxide reductase
TC41_RS13000	COG0735	belongs to the Fur family
TC41_RS13005	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS13010	COG1113	amino acid transport
TC41_RS13020	COG2204	response regulator
TC41_RS13025	COG0277	FAD linked oxidase domain protein
TC41_RS13030	COG2271	Major facilitator Superfamily
TC41_RS13035	COG2267	carboxylic ester hydrolase activity
TC41_RS13040	COG1620	l-lactate permease
TC41_RS13045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TC41_RS13050	COG1414	Transcriptional regulator
TC41_RS13055	COG0277	FAD linked oxidase domain protein
TC41_RS13060	COG0247	lactate metabolic process
TC41_RS13065	COG0277	FAD linked oxidase domain protein
TC41_RS13110	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TC41_RS13115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TC41_RS13120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TC41_RS13130	COG0653	protein targeting
TC41_RS13140	COG0438	transferase activity, transferring glycosyl groups
TC41_RS13155	COG0463	Glycosyl transferase, family 2
TC41_RS13155	COG0457	Tetratricopeptide repeat
TC41_RS13170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TC41_RS13205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TC41_RS13210	COG5002	protein histidine kinase activity
TC41_RS13215	COG0745	RESPONSE REGULATOR receiver
TC41_RS13230	COG2197	response regulator
TC41_RS13235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TC41_RS13245	COG2814	Major facilitator Superfamily
TC41_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TC41_RS13255	COG0412	Dienelactone hydrolase
TC41_RS13260	COG0521	Mo-molybdopterin cofactor biosynthetic process
TC41_RS13265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TC41_RS13270	COG1073	alpha beta
TC41_RS13325	COG0384	phenazine biosynthesis protein PhzF
TC41_RS13330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TC41_RS13340	COG1187	pseudouridine synthase activity
TC41_RS13375	COG0667	Aldo Keto reductase
TC41_RS13380	COG0785	Cytochrome C biogenesis protein
TC41_RS13425	COG0477	Major facilitator Superfamily
TC41_RS13430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TC41_RS13435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TC41_RS13450	COG2814	Major facilitator Superfamily
TC41_RS13465	COG0803	Belongs to the bacterial solute-binding protein 9 family
TC41_RS13485	COG1607	acyl-coa hydrolase
TC41_RS13500	COG5001	Diguanylate cyclase
TC41_RS13500	COG3300	MHYT domain
TC41_RS13505	COG0673	inositol 2-dehydrogenase activity
TC41_RS13510	COG2814	Major facilitator Superfamily
TC41_RS13525	COG2372	response to copper ion
TC41_RS13525	COG1276	copper resistance
TC41_RS13530	COG4549	nuclear export factor GLE1
TC41_RS13535	COG0306	phosphate transporter
TC41_RS13555	COG1472	Belongs to the glycosyl hydrolase 3 family
TC41_RS13560	COG0395	ABC-type sugar transport system, permease component
TC41_RS13580	COG0671	phosphoesterase, PA-phosphatase related
TC41_RS13595	COG1595	DNA-templated transcription, initiation
TC41_RS13620	COG1937	Protein conserved in bacteria
TC41_RS13630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_RS13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TC41_RS13635	COG0425	Belongs to the sulfur carrier protein TusA family
TC41_RS13635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TC41_RS13640	COG2210	Belongs to the sulfur carrier protein TusA family
TC41_RS13650	COG0730	response to heat
TC41_RS13675	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TC41_RS13680	COG1518	maintenance of DNA repeat elements
TC41_RS13720	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TC41_RS13725	COG2608	mercury ion transmembrane transporter activity
TC41_RS13730	COG1937	Protein conserved in bacteria
TC41_RS13735	COG1302	Protein conserved in bacteria
TC41_RS13750	COG1302	Protein conserved in bacteria
TC41_RS13755	COG1522	sequence-specific DNA binding
TC41_RS13760	COG0436	Aminotransferase
TC41_RS13765	COG2271	Major facilitator Superfamily
TC41_RS13770	COG1064	alcohol dehydrogenase
TC41_RS13775	COG1309	transcriptional regulator
TC41_RS13780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TC41_RS13790	COG4372	Transposase
TC41_RS13825	COG4372	Transposase
TC41_RS13860	COG3328	transposase activity
TC41_RS13875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TC41_RS13880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TC41_RS13885	COG4856	YbbR-like protein
TC41_RS13890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TC41_RS13900	COG0726	polysaccharide deacetylase
TC41_RS13910	COG0489	protein tyrosine kinase activity
TC41_RS13920	COG0860	N-Acetylmuramoyl-L-alanine amidase
TC41_RS13925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TC41_RS13930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TC41_RS13935	COG0101	tRNA pseudouridine synthase activity
TC41_RS13940	COG0203	ribosomal protein L17
TC41_RS13945	COG0202	RNA polymerase activity
TC41_RS13950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TC41_RS13955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TC41_RS13960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TC41_RS13965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TC41_RS13970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TC41_RS13980	COG0563	adenylate kinase activity
TC41_RS13985	COG0201	protein transport
TC41_RS14000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TC41_RS14005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TC41_RS14010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TC41_RS14015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TC41_RS14020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TC41_RS14025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TC41_RS14030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TC41_RS14035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TC41_RS14045	COG0255	Belongs to the universal ribosomal protein uL29 family
TC41_RS14050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TC41_RS14055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TC41_RS14060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TC41_RS14065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TC41_RS14070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TC41_RS14075	COG0089	rRNA binding
TC41_RS14085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TC41_RS14090	COG0051	transcription antitermination factor activity, RNA binding
TC41_RS14095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TC41_RS14100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TC41_RS14105	COG0049	tRNA binding
TC41_RS14115	COG1358	cellular component organization or biogenesis
TC41_RS14120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TC41_RS14125	COG0085	RNA polymerase activity
TC41_RS14130	COG2813	Specifically methylates the guanine in position
TC41_RS14135	COG0222	ribosome binding
TC41_RS14140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TC41_RS14145	COG0081	regulation of translation
TC41_RS14150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TC41_RS14155	COG0250	Participates in transcription elongation, termination and antitermination
TC41_RS14165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TC41_RS14180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TC41_RS14185	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TC41_RS14190	COG0215	cysteine-tRNA ligase activity
TC41_RS14195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TC41_RS14200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TC41_RS14205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TC41_RS14215	COG1183	phosphatidylcholine synthase activity
TC41_RS14220	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TC41_RS14225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TC41_RS14230	COG0542	response to heat
TC41_RS14240	COG3880	PFAM UvrB UvrC protein
TC41_RS14245	COG4463	regulation of RNA biosynthetic process
TC41_RS14265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TC41_RS14270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TC41_RS14275	COG4786	Flagellar basal body rod
TC41_RS14280	COG4786	Flagellar basal body rod
TC41_RS14290	COG1609	Transcriptional regulator
TC41_RS14295	COG0739	heme binding
TC41_RS14305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TC41_RS14320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TC41_RS14325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TC41_RS14330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TC41_RS14335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TC41_RS14340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TC41_RS14345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TC41_RS14350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TC41_RS14355	COG0356	it plays a direct role in the translocation of protons across the membrane
TC41_RS14370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TC41_RS14375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TC41_RS14380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TC41_RS14385	COG4475	Protein of unknown function (DUF436)
TC41_RS14390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TC41_RS14395	COG1971	Probably functions as a manganese efflux pump
TC41_RS14405	COG3619	membrane
TC41_RS14420	COG0009	L-threonylcarbamoyladenylate synthase
TC41_RS14430	COG2890	protein-(glutamine-N5) methyltransferase activity
TC41_RS14435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TC41_RS14440	COG0254	rRNA binding
TC41_RS14450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TC41_RS14455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TC41_RS14465	COG0504	CTP synthase activity
TC41_RS14470	COG3343	RNA polymerase activity
TC41_RS14475	COG1024	Enoyl-CoA hydratase
TC41_RS14480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TC41_RS14485	COG1984	allophanate hydrolase subunit 2
TC41_RS14490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TC41_RS14495	COG1216	Glycosyl transferase, family 2
TC41_RS14510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TC41_RS14515	COG1960	acyl-CoA dehydrogenase activity
TC41_RS14520	COG0604	alcohol dehydrogenase
TC41_RS14520	COG3321	synthase
TC41_RS14520	COG1028	Short-chain dehydrogenase reductase Sdr
TC41_RS14525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TC41_RS14530	COG0436	Aminotransferase
TC41_RS14560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TC41_RS14565	COG1803	Methylglyoxal synthase
TC41_RS14595	COG2271	Major facilitator Superfamily
TC41_RS14600	COG1070	Carbohydrate kinase
TC41_RS14620	COG2873	o-acetylhomoserine
TC41_RS14630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TC41_RS14640	COG0302	gtp cyclohydrolase
TC41_RS14645	COG0142	geranyltranstransferase activity
TC41_RS14660	COG2124	cytochrome p450
TC41_RS14670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TC41_RS14690	COG2318	DinB family
TC41_RS14715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TC41_RS14720	COG0813	purine-nucleoside phosphorylase activity
TC41_RS14725	COG2171	N-acyltransferase activity
TC41_RS14730	COG1473	amidohydrolase
TC41_RS14735	COG0436	Aminotransferase
TC41_RS14755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TC41_RS14765	COG4208	sulfate ABC transporter
TC41_RS14770	COG0789	Transcriptional regulator
TC41_RS14775	COG1960	acyl-CoA dehydrogenase activity
TC41_RS14780	COG0318	PFAM AMP-dependent synthetase and ligase
TC41_RS14785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TC41_RS14795	COG0390	transport system, permease component
TC41_RS14800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TC41_RS14805	COG2130	NADP-dependent
TC41_RS14825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TC41_RS14850	COG1609	Transcriptional regulator
TC41_RS14855	COG3833	ABC-type maltose transport systems, permease component
TC41_RS14860	COG1175	transmembrane transport
TC41_RS14885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TC41_RS14900	COG0477	Major facilitator Superfamily
TC41_RS14935	COG1203	CRISPR-associated helicase, Cas3
TC41_RS14960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TC41_RS14965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TC41_RS14970	COG0179	Fumarylacetoacetate (FAA) hydrolase
TC41_RS14975	COG1501	Belongs to the glycosyl hydrolase 31 family
TC41_RS14980	COG0589	response to stress
TC41_RS14985	COG4166	transmembrane transport
TC41_RS15000	COG1874	Beta-galactosidase
TC41_RS15005	COG0004	ammonium transporteR
TC41_RS15010	COG0347	Belongs to the P(II) protein family
TC41_RS15035	COG3534	alpha-L-arabinofuranosidase
TC41_RS15040	COG0395	ABC-type sugar transport system, permease component
TC41_RS15065	COG2160	L-arabinose isomerase activity
TC41_RS15075	COG1069	ribulokinase activity
TC41_RS15080	COG2814	Major facilitator Superfamily
TC41_RS15085	COG1609	Transcriptional regulator
TC41_RS15105	COG2814	Major facilitator Superfamily
TC41_RS15110	COG1566	PFAM secretion protein HlyD family protein
TC41_RS15115	COG0484	heat shock protein binding
TC41_RS15120	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
TC41_RS15125	COG5001	Diguanylate cyclase
TC41_RS15125	COG3300	MHYT domain
TC41_RS15135	COG0583	DNA-binding transcription factor activity
TC41_RS15145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TC41_RS15150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TC41_RS15165	COG5002	protein histidine kinase activity
TC41_RS15170	COG0745	RESPONSE REGULATOR receiver
TC41_RS15180	COG0305	Participates in initiation and elongation during chromosome replication
TC41_RS15185	COG0359	binds to the 23S rRNA
TC41_RS15200	COG0629	single-stranded DNA binding
TC41_RS15205	COG0360	Binds together with S18 to 16S ribosomal RNA
TC41_RS15210	COG0012	GTP binding
TC41_RS15215	COG0243	molybdopterin cofactor binding
TC41_RS15220	COG4481	Protein conserved in bacteria
TC41_RS15225	COG0668	transmembrane transport
TC41_RS15245	COG1811	Na channel or pump
TC41_RS15250	COG1475	DNA binding
TC41_RS15255	COG1192	Involved in chromosome partitioning
TC41_RS15260	COG1475	DNA binding
TC41_RS15265	COG0357	Ribosomal RNA small subunit methyltransferase G
TC41_RS15270	COG0445	tRNA wobble uridine modification
TC41_RS15275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TC41_RS15280	COG1847	R3H domain protein
TC41_RS15285	COG0706	membrane insertase activity
TC41_RS15290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TC41_RS15300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TC41_RS15340	COG1129	ABC transporter
TC41_RS15345	COG1129	ABC transporter
TC41_RS15350	COG0235	Class ii aldolase
TC41_RS15355	COG0557	exoribonuclease II activity
TC41_RS15360	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TC41_RS15365	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TC41_RS15385	COG3437	response regulator, receiver
TC41_RS15470	COG1609	Transcriptional regulator
TC41_RS15475	COG1609	Transcriptional regulator
TC41_RS15485	COG1131	(ABC) transporter