locus-tag	class	description
K1I37_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1I37_RS00010	COG0592	DNA-directed DNA polymerase activity
K1I37_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1I37_RS00025	COG0187	DNA topoisomerase II activity
K1I37_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K1I37_RS00035	COG2329	Antibiotic biosynthesis monooxygenase
K1I37_RS00060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K1I37_RS00075	COG0516	GMP reductase activity
K1I37_RS00075	COG0517	IMP dehydrogenase activity
K1I37_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K1I37_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K1I37_RS00105	COG0582	viral genome integration into host DNA
K1I37_RS00265	COG3328	transposase activity
K1I37_RS00315	COG4372	Transposase
K1I37_RS00355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_RS00465	COG0675	Transposase, IS605 OrfB family
K1I37_RS00470	COG1518	maintenance of DNA repeat elements
K1I37_RS00470	COG1468	defense response to virus
K1I37_RS00475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K1I37_RS00480	COG1349	DNA-binding transcription factor activity
K1I37_RS00485	COG1063	alcohol dehydrogenase
K1I37_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS00495	COG0698	ribose 5-phosphate isomerase
K1I37_RS00500	COG2376	Dihydroxyacetone kinase
K1I37_RS00510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K1I37_RS00515	COG2814	Major facilitator Superfamily
K1I37_RS00545	COG1940	carbohydrate kinase activity
K1I37_RS00545	COG1846	Transcriptional regulator
K1I37_RS00550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K1I37_RS00555	COG1522	sequence-specific DNA binding
K1I37_RS00560	COG1363	Peptidase, m42
K1I37_RS00565	COG0747	negative chemotaxis
K1I37_RS00575	COG3483	tryptophan 2,3-dioxygenase activity
K1I37_RS00580	COG3844	kynureninase activity
K1I37_RS00585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K1I37_RS00615	COG0840	transmembrane signaling receptor activity
K1I37_RS00615	COG3290	protein histidine kinase activity
K1I37_RS00620	COG0579	oxidoreductase
K1I37_RS00645	COG2814	Major facilitator Superfamily
K1I37_RS00670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_RS00675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K1I37_RS00680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K1I37_RS00685	COG2068	MobA-Related Protein
K1I37_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS00695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_RS00700	COG1802	Transcriptional regulator
K1I37_RS00705	COG0477	Major facilitator Superfamily
K1I37_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1I37_RS00725	COG0129	dihydroxy-acid dehydratase activity
K1I37_RS00730	COG0477	Major facilitator Superfamily
K1I37_RS00750	COG0235	Class ii aldolase
K1I37_RS00755	COG1063	alcohol dehydrogenase
K1I37_RS00765	COG2271	Major facilitator Superfamily
K1I37_RS00780	COG1271	oxidase subunit
K1I37_RS00785	COG1294	oxidase, subunit
K1I37_RS00790	COG4988	ABC transporter
K1I37_RS00795	COG1132	(ABC) transporter
K1I37_RS00805	COG1733	regulation of RNA biosynthetic process
K1I37_RS00815	COG3069	C4-dicarboxylate transmembrane transporter activity
K1I37_RS00820	COG2986	histidine ammonia-lyase
K1I37_RS00825	COG2508	Transcriptional regulator
K1I37_RS00830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K1I37_RS00850	COG0693	protein deglycase activity
K1I37_RS00865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_RS00895	COG0004	ammonium transporteR
K1I37_RS00900	COG0174	glutamine synthetase
K1I37_RS00920	COG0477	Major facilitator Superfamily
K1I37_RS00925	COG5002	protein histidine kinase activity
K1I37_RS00930	COG0534	Mate efflux family protein
K1I37_RS00950	COG4191	Histidine kinase
K1I37_RS00970	COG0791	NLP P60 protein
K1I37_RS00970	COG1388	LysM domain
K1I37_RS00970	COG3103	Sh3 type 3 domain protein
K1I37_RS01010	COG1435	thymidine kinase activity
K1I37_RS01025	COG1940	carbohydrate kinase activity
K1I37_RS01030	COG4213	ABC transporter substrate-binding protein
K1I37_RS01040	COG4214	carbohydrate transport
K1I37_RS01045	COG4213	ABC transporter substrate-binding protein
K1I37_RS01050	COG2309	aminopeptidase activity
K1I37_RS01060	COG1309	transcriptional regulator
K1I37_RS01065	COG1511	domain protein
K1I37_RS01075	COG3973	AAA domain
K1I37_RS01080	COG0697	spore germination
K1I37_RS01085	COG1940	carbohydrate kinase activity
K1I37_RS01130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K1I37_RS01135	COG1850	ribulose-bisphosphate carboxylase activity
K1I37_RS01140	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K1I37_RS01145	COG0235	Class ii aldolase
K1I37_RS01150	COG0367	asparagine synthase
K1I37_RS01180	COG3852	Histidine kinase
K1I37_RS01190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K1I37_RS01195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K1I37_RS01210	COG2244	polysaccharide biosynthetic process
K1I37_RS01225	COG1982	Orn Lys Arg decarboxylase major
K1I37_RS01230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1I37_RS01235	COG3870	Protein conserved in bacteria
K1I37_RS01245	COG1774	PSP1 C-terminal conserved region
K1I37_RS01250	COG4467	Involved in initiation control of chromosome replication
K1I37_RS01255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K1I37_RS01260	COG2002	toxin-antitoxin pair type II binding
K1I37_RS01270	COG0084	hydrolase, TatD family'
K1I37_RS01275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K1I37_RS01280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1I37_RS01300	COG4466	Protein conserved in bacteria
K1I37_RS01315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K1I37_RS01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1I37_RS01320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K1I37_RS01325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_RS01330	COG0251	oxidation-reduction process
K1I37_RS01335	COG2088	sporulation resulting in formation of a cellular spore
K1I37_RS01340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1I37_RS01350	COG0193	aminoacyl-tRNA hydrolase activity
K1I37_RS01360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K1I37_RS01365	COG2002	toxin-antitoxin pair type II binding
K1I37_RS01370	COG2244	polysaccharide biosynthetic process
K1I37_RS01375	COG3956	TIGRFAM MazG family protein
K1I37_RS01385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K1I37_RS01405	COG1098	S1 RNA binding domain
K1I37_RS01425	COG2131	deaminase
K1I37_RS01430	COG2208	phosphoserine phosphatase activity
K1I37_RS01435	COG2304	oxidoreductase activity
K1I37_RS01455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_RS01465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K1I37_RS01470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K1I37_RS01475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K1I37_RS01480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K1I37_RS01485	COG1396	sequence-specific DNA binding
K1I37_RS01490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1I37_RS01495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K1I37_RS01515	COG1309	transcriptional regulator
K1I37_RS01520	COG4463	regulation of RNA biosynthetic process
K1I37_RS01525	COG3880	PFAM UvrB UvrC protein
K1I37_RS01530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K1I37_RS01535	COG0542	response to heat
K1I37_RS01540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K1I37_RS01545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K1I37_RS01550	COG1183	phosphatidylcholine synthase activity
K1I37_RS01555	COG4956	integral membrane protein (PIN domain superfamily)
K1I37_RS01560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K1I37_RS01565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K1I37_RS01570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_RS01575	COG0215	cysteine-tRNA ligase activity
K1I37_RS01580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K1I37_RS01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1I37_RS01590	COG3688	RNA-binding protein containing a PIN domain
K1I37_RS01600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1I37_RS01610	COG0250	Participates in transcription elongation, termination and antitermination
K1I37_RS01620	COG0081	regulation of translation
K1I37_RS01630	COG0222	ribosome binding
K1I37_RS01635	COG2813	Specifically methylates the guanine in position
K1I37_RS01640	COG0085	RNA polymerase activity
K1I37_RS01645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K1I37_RS01650	COG1358	cellular component organization or biogenesis
K1I37_RS01655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1I37_RS01660	COG0049	tRNA binding
K1I37_RS01665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1I37_RS01670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1I37_RS01675	COG0051	transcription antitermination factor activity, RNA binding
K1I37_RS01680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1I37_RS01685	COG0088	Forms part of the polypeptide exit tunnel
K1I37_RS01690	COG0089	rRNA binding
K1I37_RS01695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1I37_RS01700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1I37_RS01705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1I37_RS01710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K1I37_RS01715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1I37_RS01720	COG0255	Belongs to the universal ribosomal protein uL29 family
K1I37_RS01730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1I37_RS01740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1I37_RS01745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1I37_RS01750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1I37_RS01755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1I37_RS01765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1I37_RS01775	COG0200	Binds to the 23S rRNA
K1I37_RS01780	COG0201	protein transport
K1I37_RS01785	COG0563	adenylate kinase activity
K1I37_RS01795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K1I37_RS01800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1I37_RS01805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1I37_RS01810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1I37_RS01815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1I37_RS01820	COG0202	RNA polymerase activity
K1I37_RS01825	COG0203	ribosomal protein L17
K1I37_RS01830	COG0101	tRNA pseudouridine synthase activity
K1I37_RS01835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1I37_RS01840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K1I37_RS01845	COG0860	N-Acetylmuramoyl-L-alanine amidase
K1I37_RS01855	COG0489	protein tyrosine kinase activity
K1I37_RS01885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K1I37_RS01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1I37_RS01900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K1I37_RS01920	COG1073	alpha beta
K1I37_RS01930	COG0640	Transcriptional regulator
K1I37_RS01940	COG2720	vancomycin resistance protein
K1I37_RS01945	COG0346	lactoylglutathione lyase activity
K1I37_RS01990	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K1I37_RS02015	COG1396	sequence-specific DNA binding
K1I37_RS02210	COG3852	Histidine kinase
K1I37_RS02215	COG5001	Diguanylate cyclase
K1I37_RS02240	COG3383	formate dehydrogenase (NAD+) activity
K1I37_RS02245	COG2427	Protein of unknown function (DUF1641)
K1I37_RS02250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1I37_RS02265	COG4988	ABC transporter
K1I37_RS02275	COG1294	oxidase, subunit
K1I37_RS02280	COG1271	oxidase subunit
K1I37_RS02295	COG3328	transposase activity
K1I37_RS02300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_RS02305	COG1982	Orn Lys Arg decarboxylase major
K1I37_RS02315	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS02345	COG4372	Transposase
K1I37_RS02355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_RS02380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K1I37_RS02450	COG4372	Transposase
K1I37_RS02470	COG3328	transposase activity
K1I37_RS02520	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_RS02520	COG3267	Type II secretory pathway component ExeA
K1I37_RS02560	COG0347	Belongs to the P(II) protein family
K1I37_RS02565	COG0004	ammonium transporteR
K1I37_RS02570	COG5002	protein histidine kinase activity
K1I37_RS02575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1I37_RS02580	COG0390	transport system, permease component
K1I37_RS02600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1I37_RS02605	COG0436	Aminotransferase
K1I37_RS02610	COG1473	amidohydrolase
K1I37_RS02615	COG2171	N-acyltransferase activity
K1I37_RS02620	COG0813	purine-nucleoside phosphorylase activity
K1I37_RS02625	COG0572	uridine kinase
K1I37_RS02630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K1I37_RS02635	COG1609	Transcriptional regulator
K1I37_RS02640	COG1070	Carbohydrate kinase
K1I37_RS02645	COG2271	Major facilitator Superfamily
K1I37_RS02650	COG0006	proline dipeptidase activity
K1I37_RS02655	COG1803	Methylglyoxal synthase
K1I37_RS02660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K1I37_RS02690	COG0436	Aminotransferase
K1I37_RS02695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_RS02700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K1I37_RS02705	COG0010	Belongs to the arginase family
K1I37_RS02720	COG1216	Glycosyl transferase, family 2
K1I37_RS02725	COG2181	nitrate reductase activity
K1I37_RS02725	COG0247	lactate metabolic process
K1I37_RS02730	COG1024	Enoyl-CoA hydratase
K1I37_RS02735	COG3343	RNA polymerase activity
K1I37_RS02740	COG0504	CTP synthase activity
K1I37_RS02755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K1I37_RS02760	COG0254	rRNA binding
K1I37_RS02765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K1I37_RS02770	COG2890	protein-(glutamine-N5) methyltransferase activity
K1I37_RS02780	COG0009	L-threonylcarbamoyladenylate synthase
K1I37_RS02790	COG1904	glucuronate isomerase
K1I37_RS02795	COG0246	Mannitol dehydrogenase
K1I37_RS02800	COG2721	sulfolactate sulfo-lyase activity
K1I37_RS02805	COG1609	Transcriptional regulator
K1I37_RS02810	COG2814	Major facilitator Superfamily
K1I37_RS02830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1I37_RS02835	COG4475	Protein of unknown function (DUF436)
K1I37_RS02840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1I37_RS02850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K1I37_RS02860	COG0356	it plays a direct role in the translocation of protons across the membrane
K1I37_RS02865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1I37_RS02870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K1I37_RS02875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1I37_RS02880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1I37_RS02885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1I37_RS02890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K1I37_RS02895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K1I37_RS02915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1I37_RS02930	COG0739	heme binding
K1I37_RS02935	COG1609	Transcriptional regulator
K1I37_RS02940	COG1077	Cell shape determining protein MreB Mrl
K1I37_RS02945	COG4786	Flagellar basal body rod
K1I37_RS02950	COG4786	Flagellar basal body rod
K1I37_RS02955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_RS02960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1I37_RS02985	COG1739	Uncharacterized protein family UPF0029
K1I37_RS03000	COG0463	Glycosyl transferase, family 2
K1I37_RS03035	COG2814	Major facilitator Superfamily
K1I37_RS03045	COG1846	Transcriptional regulator
K1I37_RS03050	COG0477	Major facilitator Superfamily
K1I37_RS03055	COG1309	transcriptional regulator
K1I37_RS03070	COG2197	response regulator
K1I37_RS03105	COG0300	oxidoreductase activity
K1I37_RS03170	COG0577	efflux transmembrane transporter activity
K1I37_RS03170	COG1136	(ABC) transporter
K1I37_RS03175	COG0577	efflux transmembrane transporter activity
K1I37_RS03175	COG1136	(ABC) transporter
K1I37_RS03210	COG5002	protein histidine kinase activity
K1I37_RS03215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K1I37_RS03220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1I37_RS03225	COG0463	Glycosyl transferase, family 2
K1I37_RS03230	COG4191	Histidine kinase
K1I37_RS03235	COG0028	Belongs to the TPP enzyme family
K1I37_RS03265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS03265	COG3711	transcriptional antiterminator
K1I37_RS03275	COG3037	sugar-specific permease SgaT UlaA
K1I37_RS03285	COG2814	Major facilitator Superfamily
K1I37_RS03310	COG1587	Uroporphyrinogen-III synthase
K1I37_RS03310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_RS03330	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K1I37_RS03365	COG1126	abc transporter atp-binding protein
K1I37_RS03370	COG0765	amino acid transport
K1I37_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1I37_RS03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_RS03385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K1I37_RS03410	COG1289	transmembrane transporter activity
K1I37_RS03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_RS03420	COG3858	chitin binding
K1I37_RS03425	COG4193	domain, Protein
K1I37_RS03445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1I37_RS03455	COG2814	Major facilitator Superfamily
K1I37_RS03470	COG0604	alcohol dehydrogenase
K1I37_RS03485	COG1063	alcohol dehydrogenase
K1I37_RS03555	COG0564	pseudouridine synthase activity
K1I37_RS03560	COG3300	MHYT domain
K1I37_RS03560	COG5001	Diguanylate cyclase
K1I37_RS03570	COG1063	alcohol dehydrogenase
K1I37_RS03580	COG1609	Transcriptional regulator
K1I37_RS03590	COG0791	NLP P60 protein
K1I37_RS03605	COG0667	Aldo Keto reductase
K1I37_RS03625	COG0667	Aldo Keto reductase
K1I37_RS03635	COG1285	pathogenesis
K1I37_RS03660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1I37_RS03665	COG1459	type II secretion system
K1I37_RS03705	COG0442	prolyl-tRNA aminoacylation
K1I37_RS03710	COG0546	phosphoglycolate phosphatase activity
K1I37_RS03720	COG1192	Involved in chromosome partitioning
K1I37_RS03725	COG5002	protein histidine kinase activity
K1I37_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS03750	COG4846	Membrane protein involved in cytochrome C biogenesis
K1I37_RS03760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_RS03770	COG1131	(ABC) transporter
K1I37_RS03785	COG1335	isochorismatase
K1I37_RS03790	COG2814	Major facilitator Superfamily
K1I37_RS03800	COG1396	sequence-specific DNA binding
K1I37_RS03815	COG1079	Belongs to the binding-protein-dependent transport system permease family
K1I37_RS03820	COG4603	Belongs to the binding-protein-dependent transport system permease family
K1I37_RS03825	COG3845	ABC transporter
K1I37_RS03830	COG1744	ABC transporter substrate-binding protein PnrA-like
K1I37_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1I37_RS03845	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K1I37_RS03865	COG0736	holo-[acyl-carrier-protein] synthase activity
K1I37_RS03870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K1I37_RS03870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K1I37_RS03875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K1I37_RS03880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1I37_RS03890	COG2337	Toxic component of a toxin-antitoxin (TA) module
K1I37_RS03895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K1I37_RS03900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K1I37_RS03910	COG1695	Transcriptional regulator
K1I37_RS03930	COG1595	DNA-templated transcription, initiation
K1I37_RS03935	COG5002	protein histidine kinase activity
K1I37_RS03970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K1I37_RS03975	COG0802	atpase or kinase
K1I37_RS03985	COG0456	acetyltransferase
K1I37_RS03990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1I37_RS03995	COG0488	(ABC) transporter
K1I37_RS04000	COG0671	phosphoesterase, PA-phosphatase related
K1I37_RS04005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K1I37_RS04010	COG0746	molybdenum cofactor guanylyltransferase activity
K1I37_RS04030	COG0459	protein refolding
K1I37_RS04080	COG0714	Associated with various cellular activities
K1I37_RS04090	COG1305	Transglutaminase-like
K1I37_RS04095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1I37_RS04095	COG0519	Catalyzes the synthesis of GMP from XMP
K1I37_RS04100	COG2252	PERMEase
K1I37_RS04105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K1I37_RS04115	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1I37_RS04120	COG0047	phosphoribosylformylglycinamidine synthase activity
K1I37_RS04125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1I37_RS04130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K1I37_RS04135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K1I37_RS04140	COG0138	bifunctional purine biosynthesis protein purh
K1I37_RS04145	COG0151	Belongs to the GarS family
K1I37_RS04170	COG2318	DinB family
K1I37_RS04175	COG1968	undecaprenyl-diphosphatase activity
K1I37_RS04180	COG1215	transferase activity, transferring glycosyl groups
K1I37_RS04185	COG2233	PERMEase
K1I37_RS04190	COG2223	nitrite transmembrane transporter activity
K1I37_RS04195	COG0436	Aminotransferase
K1I37_RS04200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1I37_RS04205	COG0175	sulfate reduction
K1I37_RS04225	COG1122	ATPase activity
K1I37_RS04230	COG1122	ATPase activity
K1I37_RS04235	COG1268	BioY protein
K1I37_RS04240	COG2807	transmembrane transport
K1I37_RS04245	COG2271	Major facilitator Superfamily
K1I37_RS04250	COG2814	Major facilitator Superfamily
K1I37_RS04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_RS04265	COG2207	Transcriptional regulator
K1I37_RS04270	COG2182	Extracellular solute-binding protein
K1I37_RS04275	COG1175	transmembrane transport
K1I37_RS04280	COG0395	ABC-type sugar transport system, permease component
K1I37_RS04300	COG0492	ferredoxin-NADP+ reductase activity
K1I37_RS04435	COG1587	Uroporphyrinogen-III synthase
K1I37_RS04440	COG4948	Mandelate Racemase Muconate Lactonizing
K1I37_RS04445	COG2884	Cell division ATP-binding protein ftsE
K1I37_RS04450	COG2177	Part of the ABC transporter FtsEX involved in
K1I37_RS04460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K1I37_RS04465	COG1360	Flagellar Motor Protein
K1I37_RS04470	COG0556	nucleotide-excision repair
K1I37_RS04475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1I37_RS04480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1I37_RS04490	COG0018	arginyl-trna synthetase
K1I37_RS04495	COG0457	Tetratricopeptide repeat
K1I37_RS04500	COG1051	belongs to the nudix hydrolase family
K1I37_RS04505	COG1660	Displays ATPase and GTPase activities
K1I37_RS04510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K1I37_RS04515	COG1481	regulation of sporulation
K1I37_RS04520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS04540	COG1194	a g-specific adenine glycosylase
K1I37_RS04545	COG0670	Belongs to the BI1 family
K1I37_RS04570	COG0628	permease
K1I37_RS04585	COG1205	dead DEAH box helicase
K1I37_RS04585	COG1111	helicase
K1I37_RS04595	COG4493	Belongs to the UPF0637 family
K1I37_RS04600	COG0737	Belongs to the 5'-nucleotidase family
K1I37_RS04605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K1I37_RS04615	COG0697	spore germination
K1I37_RS04630	COG0328	RNA-DNA hybrid ribonuclease activity
K1I37_RS04635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K1I37_RS04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1I37_RS04650	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_RS04670	COG0546	phosphoglycolate phosphatase activity
K1I37_RS04700	COG2814	Major facilitator Superfamily
K1I37_RS04705	COG1247	-acetyltransferase
K1I37_RS04720	COG0697	spore germination
K1I37_RS04745	COG2718	Belongs to the UPF0229 family
K1I37_RS04750	COG2719	SpoVR family
K1I37_RS04770	COG0697	spore germination
K1I37_RS04780	COG1827	regulation of RNA biosynthetic process
K1I37_RS04795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1I37_RS04800	COG1234	tRNA 3'-trailer cleavage
K1I37_RS04805	COG2814	Major facilitator Superfamily
K1I37_RS04815	COG3263	regulation of cellular component size
K1I37_RS04820	COG1131	(ABC) transporter
K1I37_RS04830	COG0477	Major facilitator Superfamily
K1I37_RS04845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1I37_RS04855	COG1845	cytochrome c oxidase, subunit III
K1I37_RS04865	COG1612	heme a metabolic process
K1I37_RS04870	COG1686	Belongs to the peptidase S11 family
K1I37_RS04875	COG0569	domain protein
K1I37_RS04880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K1I37_RS04900	COG0667	Aldo Keto reductase
K1I37_RS04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_RS04915	COG1454	alcohol dehydrogenase
K1I37_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS04930	COG5001	Diguanylate cyclase
K1I37_RS04930	COG3300	MHYT domain
K1I37_RS04945	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_RS04955	COG2149	membrane
K1I37_RS04960	COG1525	nuclease
K1I37_RS04995	COG0783	Belongs to the Dps family
K1I37_RS05005	COG1335	isochorismatase
K1I37_RS05030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1I37_RS05040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_RS05045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1I37_RS05050	COG0154	amidase activity
K1I37_RS05055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1I37_RS05060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1I37_RS05070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_RS05075	COG1869	D-ribose catabolic process
K1I37_RS05080	COG1129	ABC transporter
K1I37_RS05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
K1I37_RS05105	COG3328	transposase activity
K1I37_RS05130	COG0725	ABC transporter, periplasmic molybdate-binding protein
K1I37_RS05140	COG3842	ATPase activity
K1I37_RS05145	COG2368	4-hydroxyphenylacetate
K1I37_RS05155	COG2031	fatty acid transporter
K1I37_RS05170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1I37_RS05180	COG3829	transcription factor binding
K1I37_RS05180	COG3290	protein histidine kinase activity
K1I37_RS05185	COG1556	Lactate utilization protein
K1I37_RS05190	COG1139	Iron-sulfur cluster binding protein
K1I37_RS05195	COG0247	lactate metabolic process
K1I37_RS05200	COG2186	Transcriptional regulator
K1I37_RS05210	COG4989	oxidoreductase activity
K1I37_RS05215	COG2423	ornithine cyclodeaminase activity
K1I37_RS05220	COG4549	nuclear export factor GLE1
K1I37_RS05225	COG2372	response to copper ion
K1I37_RS05225	COG1276	copper resistance
K1I37_RS05235	COG2217	Heavy metal translocating P-type atpase
K1I37_RS05240	COG2197	response regulator
K1I37_RS05245	COG4585	Histidine kinase
K1I37_RS05250	COG0840	transmembrane signaling receptor activity
K1I37_RS05260	COG2201	protein-glutamate methylesterase activity
K1I37_RS05270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K1I37_RS05275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K1I37_RS05280	COG0281	malic enzyme
K1I37_RS05285	COG0596	Alpha beta hydrolase
K1I37_RS05300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1I37_RS05305	COG1846	Transcriptional regulator
K1I37_RS05310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K1I37_RS05330	COG2155	Conserved Protein
K1I37_RS05335	COG0019	diaminopimelate decarboxylase activity
K1I37_RS05355	COG0295	cytidine deaminase activity
K1I37_RS05360	COG1164	Oligoendopeptidase f
K1I37_RS05365	COG4191	Histidine kinase
K1I37_RS05375	COG0126	phosphoglycerate kinase activity
K1I37_RS05380	COG0149	triose-phosphate isomerase activity
K1I37_RS05385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K1I37_RS05390	COG0148	phosphopyruvate hydratase activity
K1I37_RS05395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K1I37_RS05400	COG0557	exoribonuclease II activity
K1I37_RS05405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K1I37_RS05440	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K1I37_RS05450	COG0444	Belongs to the ABC transporter superfamily
K1I37_RS05455	COG4608	Belongs to the ABC transporter superfamily
K1I37_RS05460	COG0601	transmembrane transport
K1I37_RS05465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_RS05475	COG0640	Transcriptional regulator
K1I37_RS05485	COG0393	Putative heavy-metal-binding
K1I37_RS05500	COG1129	ABC transporter
K1I37_RS05510	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K1I37_RS05525	COG2814	Major facilitator Superfamily
K1I37_RS05555	COG2814	Major facilitator Superfamily
K1I37_RS05575	COG1959	2 iron, 2 sulfur cluster binding
K1I37_RS05580	COG0702	epimerase
K1I37_RS05615	COG0708	Exodeoxyribonuclease III
K1I37_RS05625	COG0745	RESPONSE REGULATOR receiver
K1I37_RS05630	COG5002	protein histidine kinase activity
K1I37_RS05660	COG0248	Ppx GppA phosphatase
K1I37_RS05670	COG3384	dioxygenase
K1I37_RS05675	COG0596	Alpha beta hydrolase
K1I37_RS05675	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_RS05680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K1I37_RS05685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_RS05705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_RS05710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_RS05715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_RS05720	COG2188	Transcriptional regulator
K1I37_RS05725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K1I37_RS05730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K1I37_RS05735	COG4208	sulfate ABC transporter
K1I37_RS05745	COG5583	Uncharacterized small protein (DUF2292)
K1I37_RS05750	COG0431	NADPH-dependent FMN reductase
K1I37_RS05755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_RS05760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_RS05765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_RS05770	COG1116	anion transmembrane transporter activity
K1I37_RS05775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K1I37_RS05805	COG0427	acetyl-CoA hydrolase
K1I37_RS05815	COG0420	3'-5' exonuclease activity
K1I37_RS05820	COG0419	ATPase involved in DNA repair
K1I37_RS05830	COG1953	Uracil, thiamine, allantoin
K1I37_RS05840	COG0493	'glutamate synthase
K1I37_RS05850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_RS05855	COG0252	asparaginase activity
K1I37_RS05865	COG0531	amino acid
K1I37_RS05875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K1I37_RS05895	COG0477	Major facilitator Superfamily
K1I37_RS05915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K1I37_RS05930	COG0804	urea catabolic process
K1I37_RS05935	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
K1I37_RS05940	COG0830	nickel cation binding
K1I37_RS05960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_RS05965	COG2115	Belongs to the xylose isomerase family
K1I37_RS05975	COG2814	Major facilitator Superfamily
K1I37_RS05980	COG3344	reverse transcriptase
K1I37_RS05990	COG0551	DNA topoisomerase type I activity
K1I37_RS05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1I37_RS05995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS05995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_RS05995	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K1I37_RS06000	COG1461	Dihydroxyacetone kinase
K1I37_RS06005	COG2376	Dihydroxyacetone kinase
K1I37_RS06010	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K1I37_RS06020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K1I37_RS06025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K1I37_RS06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_RS06035	COG0531	amino acid
K1I37_RS06040	COG0667	Aldo Keto reductase
K1I37_RS06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1I37_RS06065	COG2814	Major facilitator Superfamily
K1I37_RS06080	COG2271	Major facilitator Superfamily
K1I37_RS06085	COG4638	Rieske (2fe-2S)
K1I37_RS06090	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K1I37_RS06095	COG1063	alcohol dehydrogenase
K1I37_RS06105	COG1802	Transcriptional regulator
K1I37_RS06115	COG0129	dihydroxy-acid dehydratase activity
K1I37_RS06125	COG0277	FAD linked oxidase domain protein
K1I37_RS06135	COG1414	Transcriptional regulator
K1I37_RS06155	COG4569	acetaldehyde dehydrogenase (acetylating) activity
K1I37_RS06170	COG1942	4-Oxalocrotonate Tautomerase
K1I37_RS06190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K1I37_RS06200	COG3383	formate dehydrogenase (NAD+) activity
K1I37_RS06210	COG2860	membrane
K1I37_RS06215	COG0583	DNA-binding transcription factor activity
K1I37_RS06220	COG1473	amidohydrolase
K1I37_RS06225	COG0747	negative chemotaxis
K1I37_RS06230	COG0697	spore germination
K1I37_RS06235	COG3711	transcriptional antiterminator
K1I37_RS06240	COG1263	PTS System
K1I37_RS06240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1I37_RS06245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K1I37_RS06245	COG1263	PTS System
K1I37_RS06250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS06255	COG2190	(PTS) system
K1I37_RS06260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K1I37_RS06265	COG0363	glucosamine-6-phosphate deaminase activity
K1I37_RS06310	COG1216	Glycosyl transferase, family 2
K1I37_RS06340	COG1086	Polysaccharide biosynthesis protein
K1I37_RS06350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_RS06360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_RS06365	COG0463	Glycosyl transferase, family 2
K1I37_RS06365	COG1216	Glycosyl transferase, family 2
K1I37_RS06375	COG0529	Catalyzes the synthesis of activated sulfate
K1I37_RS06405	COG5609	conserved protein (DUF2294)
K1I37_RS06410	COG2116	formate transmembrane transporter activity
K1I37_RS06415	COG3383	formate dehydrogenase (NAD+) activity
K1I37_RS06440	COG3385	transposase activity
K1I37_RS06445	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_RS06450	COG1492	cobalamin metabolic process
K1I37_RS06465	COG0617	tRNA 3'-terminal CCA addition
K1I37_RS06475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1I37_RS06485	COG1032	radical SAM domain protein
K1I37_RS06500	COG0542	response to heat
K1I37_RS06520	COG3385	transposase activity
K1I37_RS06525	COG3328	transposase activity
K1I37_RS06535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1I37_RS06550	COG2078	PFAM AMMECR1 domain protein
K1I37_RS06550	COG3885	ferrous iron binding
K1I37_RS06555	COG2116	formate transmembrane transporter activity
K1I37_RS06560	COG3383	formate dehydrogenase (NAD+) activity
K1I37_RS06575	COG3328	transposase activity
K1I37_RS06580	COG1741	Belongs to the pirin family
K1I37_RS06600	COG1070	Carbohydrate kinase
K1I37_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS06605	COG3347	Dehydrogenase
K1I37_RS06610	COG4952	isomerase
K1I37_RS06615	COG2814	Major facilitator Superfamily
K1I37_RS06625	COG1349	DNA-binding transcription factor activity
K1I37_RS06630	COG3511	phospholipase C
K1I37_RS06660	COG1846	Transcriptional regulator
K1I37_RS06680	COG0656	L-ascorbic acid biosynthetic process
K1I37_RS06685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_RS06690	COG4191	Histidine kinase
K1I37_RS06700	COG3328	transposase activity
K1I37_RS06705	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS06710	COG1024	Enoyl-CoA hydratase
K1I37_RS06725	COG0519	Catalyzes the synthesis of GMP from XMP
K1I37_RS06735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1I37_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS06745	COG0077	Prephenate dehydratase
K1I37_RS06745	COG1605	Chorismate mutase
K1I37_RS06755	COG0488	(ABC) transporter
K1I37_RS06760	COG0531	amino acid
K1I37_RS06765	COG0513	Belongs to the DEAD box helicase family
K1I37_RS06775	COG1119	ATPase activity
K1I37_RS06780	COG1671	Belongs to the UPF0178 family
K1I37_RS06785	COG2353	YceI-like domain
K1I37_RS06790	COG1733	regulation of RNA biosynthetic process
K1I37_RS06815	COG0529	Catalyzes the synthesis of activated sulfate
K1I37_RS06820	COG2046	Belongs to the sulfate adenylyltransferase family
K1I37_RS06825	COG0483	inositol monophosphate 1-phosphatase activity
K1I37_RS06835	COG2183	response to ionizing radiation
K1I37_RS06850	COG3153	acetyltransferase
K1I37_RS06850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_RS06855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_RS06855	COG0723	plastoquinol--plastocyanin reductase activity
K1I37_RS06860	COG3361	conserved protein (COG2071)
K1I37_RS06865	COG3011	Protein conserved in bacteria
K1I37_RS06880	COG1063	alcohol dehydrogenase
K1I37_RS06910	COG0667	Aldo Keto reductase
K1I37_RS06915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_RS06920	COG0561	phosphatase activity
K1I37_RS06925	COG0673	inositol 2-dehydrogenase activity
K1I37_RS06930	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS06935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1I37_RS06940	COG1335	isochorismatase
K1I37_RS06950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_RS06955	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS06965	COG0598	Magnesium transport protein CorA
K1I37_RS06970	COG3973	AAA domain
K1I37_RS06990	COG0477	Major facilitator Superfamily
K1I37_RS06995	COG2814	Major facilitator Superfamily
K1I37_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS07015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K1I37_RS07025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1I37_RS07040	COG1077	Cell shape determining protein MreB Mrl
K1I37_RS07045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_RS07050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_RS07050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_RS07050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS07055	COG1349	DNA-binding transcription factor activity
K1I37_RS07060	COG1105	Belongs to the carbohydrate kinase PfkB family
K1I37_RS07065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS07065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_RS07065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1I37_RS07075	COG5002	protein histidine kinase activity
K1I37_RS07090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1I37_RS07110	COG0154	amidase activity
K1I37_RS07115	COG2363	Small membrane protein
K1I37_RS07125	COG0626	cystathionine gamma-synthase activity
K1I37_RS07130	COG0424	maF-like protein
K1I37_RS07150	COG2081	HI0933 family
K1I37_RS07155	COG1979	alcohol dehydrogenase
K1I37_RS07160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K1I37_RS07165	COG0116	Belongs to the methyltransferase superfamily
K1I37_RS07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_RS07175	COG0109	protoheme IX farnesyltransferase activity
K1I37_RS07185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_RS07195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K1I37_RS07200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K1I37_RS07205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K1I37_RS07210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1I37_RS07215	COG0131	Imidazoleglycerol-phosphate dehydratase
K1I37_RS07225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K1I37_RS07235	COG0140	phosphoribosyl-ATP diphosphatase activity
K1I37_RS07235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K1I37_RS07240	COG2271	Major facilitator Superfamily
K1I37_RS07245	COG3290	protein histidine kinase activity
K1I37_RS07250	COG4565	transcriptional regulatory protein
K1I37_RS07255	COG0667	Aldo Keto reductase
K1I37_RS07260	COG0697	spore germination
K1I37_RS07270	COG1494	fructose-1,6-bisphosphatase
K1I37_RS07275	COG4721	ABC-type cobalt transport system, permease component
K1I37_RS07280	COG1122	ATPase activity
K1I37_RS07295	COG1742	UPF0060 membrane protein
K1I37_RS07305	COG0583	DNA-binding transcription factor activity
K1I37_RS07310	COG2271	Major facilitator Superfamily
K1I37_RS07330	COG0066	3-isopropylmalate dehydratase activity
K1I37_RS07335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1I37_RS07345	COG0066	3-isopropylmalate dehydratase activity
K1I37_RS07360	COG0583	DNA-binding transcription factor activity
K1I37_RS07385	COG0456	acetyltransferase
K1I37_RS07385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K1I37_RS07405	COG0583	DNA-binding transcription factor activity
K1I37_RS07415	COG1053	succinate dehydrogenase
K1I37_RS07420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_RS07430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_RS07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_RS07440	COG1116	anion transmembrane transporter activity
K1I37_RS07445	COG0482	sulfurtransferase activity
K1I37_RS07475	COG1960	acyl-CoA dehydrogenase activity
K1I37_RS07490	COG1213	nucleotidyl transferase
K1I37_RS07500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K1I37_RS07535	COG0564	pseudouridine synthase activity
K1I37_RS07540	COG1295	ribonuclease BN
K1I37_RS07545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K1I37_RS07560	COG1363	Peptidase, m42
K1I37_RS07565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_RS07570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_RS07575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_RS07610	COG0840	transmembrane signaling receptor activity
K1I37_RS07645	COG0302	gtp cyclohydrolase
K1I37_RS07655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K1I37_RS07665	COG0167	dihydroorotate dehydrogenase activity
K1I37_RS07670	COG1595	DNA-templated transcription, initiation
K1I37_RS07685	COG0686	Belongs to the AlaDH PNT family
K1I37_RS07690	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_RS07695	COG0396	ATPase activity
K1I37_RS07700	COG0719	Fe-S assembly protein
K1I37_RS07705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K1I37_RS07710	COG0822	iron-sulfur transferase activity
K1I37_RS07715	COG0719	Fe-S assembly protein
K1I37_RS07730	COG0789	Transcriptional regulator
K1I37_RS07755	COG0450	alkyl hydroperoxide reductase
K1I37_RS07765	COG1309	transcriptional regulator
K1I37_RS07770	COG2086	electron transfer activity
K1I37_RS07775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K1I37_RS07790	COG0114	fumarate hydratase activity
K1I37_RS07795	COG1506	peptidase
K1I37_RS07795	COG4946	Tricorn protease homolog
K1I37_RS07795	COG0823	Involved in the tonB-independent uptake of proteins
K1I37_RS07805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K1I37_RS07810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K1I37_RS07825	COG0531	amino acid
K1I37_RS07830	COG0438	transferase activity, transferring glycosyl groups
K1I37_RS07865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_RS07880	COG0583	DNA-binding transcription factor activity
K1I37_RS07930	COG0587	DNA-directed DNA polymerase activity
K1I37_RS07935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1I37_RS07940	COG0671	phosphoesterase, PA-phosphatase related
K1I37_RS07955	COG0537	adenosine 5'-monophosphoramidase activity
K1I37_RS07960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K1I37_RS07975	COG2340	Cysteine-rich secretory protein family
K1I37_RS07985	COG0583	DNA-binding transcription factor activity
K1I37_RS08025	COG0463	Glycosyl transferase, family 2
K1I37_RS08030	COG1024	Enoyl-CoA hydratase
K1I37_RS08030	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_RS08035	COG0183	Belongs to the thiolase family
K1I37_RS08040	COG1960	acyl-CoA dehydrogenase activity
K1I37_RS08045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K1I37_RS08050	COG0768	penicillin binding
K1I37_RS08055	COG0477	Major facilitator Superfamily
K1I37_RS08070	COG0612	Peptidase, M16
K1I37_RS08075	COG0612	Peptidase, M16
K1I37_RS08080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_RS08085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K1I37_RS08090	COG0083	homoserine kinase activity
K1I37_RS08100	COG2050	protein possibly involved in aromatic compounds catabolism
K1I37_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS08115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_RS08120	COG0154	amidase activity
K1I37_RS08140	COG1956	GAF domain-containing protein
K1I37_RS08145	COG1393	Belongs to the ArsC family
K1I37_RS08160	COG0772	Belongs to the SEDS family
K1I37_RS08170	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_RS08175	COG0772	Belongs to the SEDS family
K1I37_RS08180	COG0436	Aminotransferase
K1I37_RS08190	COG4145	pantothenate transmembrane transporter activity
K1I37_RS08200	COG1085	galactose-1-phosphate uridylyltransferase
K1I37_RS08205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K1I37_RS08210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_RS08230	COG1982	Orn Lys Arg decarboxylase major
K1I37_RS08235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K1I37_RS08240	COG0316	Belongs to the HesB IscA family
K1I37_RS08245	COG1078	dGTPase activity
K1I37_RS08250	COG0586	Pfam SNARE associated Golgi protein
K1I37_RS08260	COG3377	Domain of unknown function (DUF1805)
K1I37_RS08265	COG1363	Peptidase, m42
K1I37_RS08270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K1I37_RS08290	COG0444	Belongs to the ABC transporter superfamily
K1I37_RS08295	COG4608	Belongs to the ABC transporter superfamily
K1I37_RS08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_RS08305	COG0601	transmembrane transport
K1I37_RS08310	COG0747	negative chemotaxis
K1I37_RS08340	COG3385	transposase activity
K1I37_RS08375	COG0697	spore germination
K1I37_RS08395	COG4221	oxidoreductase activity
K1I37_RS08400	COG0069	glutamate synthase activity
K1I37_RS08430	COG4372	Transposase
K1I37_RS08435	COG0531	amino acid
K1I37_RS08485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_RS08505	COG2309	aminopeptidase activity
K1I37_RS08520	COG2207	Transcriptional regulator
K1I37_RS08535	COG0583	DNA-binding transcription factor activity
K1I37_RS08540	COG0583	DNA-binding transcription factor activity
K1I37_RS08555	COG1472	Belongs to the glycosyl hydrolase 3 family
K1I37_RS08560	COG2391	methyltransferase activity
K1I37_RS08575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K1I37_RS08590	COG2814	Major facilitator Superfamily
K1I37_RS08600	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS08650	COG1910	domain protein
K1I37_RS08655	COG0251	oxidation-reduction process
K1I37_RS08660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K1I37_RS08665	COG4224	UPF0291 protein
K1I37_RS08680	COG0791	NLP P60 protein
K1I37_RS08740	COG0512	Glutamine amidotransferase of anthranilate synthase
K1I37_RS08755	COG1247	-acetyltransferase
K1I37_RS08775	COG1126	abc transporter atp-binding protein
K1I37_RS08780	COG0765	amino acid transport
K1I37_RS08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1I37_RS08800	COG0163	prenyltransferase activity
K1I37_RS08815	COG0747	negative chemotaxis
K1I37_RS08820	COG2271	Major facilitator Superfamily
K1I37_RS08825	COG1063	alcohol dehydrogenase
K1I37_RS08835	COG1832	CoA-binding protein
K1I37_RS08845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K1I37_RS08850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1I37_RS08855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_RS08865	COG0069	glutamate synthase activity
K1I37_RS08865	COG0070	glutamate synthase
K1I37_RS08865	COG0067	glutamate synthase
K1I37_RS08870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K1I37_RS08875	COG0137	argininosuccinate synthase activity
K1I37_RS08880	COG0165	Argininosuccinate lyase
K1I37_RS08890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K1I37_RS08895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K1I37_RS08920	COG2003	Belongs to the UPF0758 family
K1I37_RS08945	COG3328	transposase activity
K1I37_RS08955	COG1584	GPR1 FUN34 yaaH family protein
K1I37_RS08960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K1I37_RS08965	COG3906	Belongs to the UPF0473 family
K1I37_RS08995	COG0740	serine-type endopeptidase activity
K1I37_RS09000	COG1104	cysteine desulfurase activity
K1I37_RS09005	COG0301	tRNA thio-modification
K1I37_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS09035	COG1902	pentaerythritol trinitrate reductase activity
K1I37_RS09040	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K1I37_RS09045	COG3344	reverse transcriptase
K1I37_RS09050	COG2001	Belongs to the MraZ family
K1I37_RS09055	COG0275	rRNA processing
K1I37_RS09065	COG0768	penicillin binding
K1I37_RS09070	COG0768	penicillin binding
K1I37_RS09075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K1I37_RS09080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1I37_RS09085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1I37_RS09090	COG0772	Belongs to the SEDS family
K1I37_RS09095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_RS09100	COG3328	transposase activity
K1I37_RS09105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1I37_RS09110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1I37_RS09130	COG3856	small basic protein
K1I37_RS09135	COG0849	cell division
K1I37_RS09140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K1I37_RS09150	COG1191	sigma factor activity
K1I37_RS09155	COG1191	sigma factor activity
K1I37_RS09160	COG1873	PFAM PRC-barrel domain
K1I37_RS09165	COG1496	oxidoreductase activity
K1I37_RS09180	COG2302	S4 RNA-binding domain
K1I37_RS09185	COG3599	regulation of cell shape
K1I37_RS09205	COG1809	phosphosulfolactate synthase activity
K1I37_RS09210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K1I37_RS09215	COG0564	pseudouridine synthase activity
K1I37_RS09220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K1I37_RS09225	COG0540	Belongs to the ATCase OTCase family
K1I37_RS09230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K1I37_RS09235	COG0505	Belongs to the CarA family
K1I37_RS09245	COG0284	orotidine-5'-phosphate decarboxylase activity
K1I37_RS09270	COG0454	-acetyltransferase
K1I37_RS09275	COG1033	growth of symbiont in host cell
K1I37_RS09275	COG2409	Drug exporters of the RND superfamily
K1I37_RS09290	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_RS09295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_RS09310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1I37_RS09315	COG1561	YicC-like family, N-terminal region
K1I37_RS09320	COG1758	RNA polymerase activity
K1I37_RS09325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1I37_RS09330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K1I37_RS09335	COG0242	peptide deformylase activity
K1I37_RS09340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1I37_RS09345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1I37_RS09345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K1I37_RS09350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K1I37_RS09355	COG0631	protein serine/threonine phosphatase activity
K1I37_RS09360	COG0515	serine threonine protein kinase
K1I37_RS09360	COG2815	serine threonine protein kinase
K1I37_RS09365	COG1162	GTPase activity
K1I37_RS09370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1I37_RS09380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1I37_RS09390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K1I37_RS09400	COG2011	ABC-type metal ion transport system permease component
K1I37_RS09405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K1I37_RS09415	COG1464	Belongs to the NlpA lipoprotein family
K1I37_RS09420	COG0688	phosphatidylethanolamine metabolic process
K1I37_RS09435	COG0154	amidase activity
K1I37_RS09445	COG0742	ribosomal rna small subunit methyltransferase
K1I37_RS09450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1I37_RS09455	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1I37_RS09465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K1I37_RS09470	COG1349	DNA-binding transcription factor activity
K1I37_RS09475	COG0416	fatty acid biosynthetic process
K1I37_RS09480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1I37_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS09490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1I37_RS09495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_RS09500	COG0571	ribonuclease III activity
K1I37_RS09505	COG1196	nuclear chromosome segregation
K1I37_RS09510	COG0552	protein localization to endoplasmic reticulum
K1I37_RS09515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K1I37_RS09520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1I37_RS09525	COG0228	four-way junction DNA binding
K1I37_RS09530	COG1837	Belongs to the UPF0109 family
K1I37_RS09545	COG0336	Belongs to the RNA methyltransferase TrmD family
K1I37_RS09565	COG3344	reverse transcriptase
K1I37_RS09570	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS09575	COG1733	regulation of RNA biosynthetic process
K1I37_RS09590	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS09595	COG1917	Cupin 2, conserved barrel domain protein
K1I37_RS09595	COG4977	sequence-specific DNA binding
K1I37_RS09600	COG1606	tRNA processing
K1I37_RS09605	COG1691	(AIR) carboxylase
K1I37_RS09635	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
K1I37_RS09640	COG1620	l-lactate permease
K1I37_RS09645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K1I37_RS09780	COG1113	amino acid transport
K1I37_RS09785	COG0673	inositol 2-dehydrogenase activity
K1I37_RS09790	COG1070	Carbohydrate kinase
K1I37_RS09810	COG2271	Major facilitator Superfamily
K1I37_RS09815	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_RS09820	COG0564	pseudouridine synthase activity
K1I37_RS09830	COG0739	heme binding
K1I37_RS09835	COG1607	acyl-coa hydrolase
K1I37_RS09860	COG0335	large ribosomal subunit rRNA binding
K1I37_RS09870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K1I37_RS09880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_RS09885	COG0792	nuclease activity
K1I37_RS09890	COG0346	lactoylglutathione lyase activity
K1I37_RS09895	COG0561	phosphatase activity
K1I37_RS09925	COG0477	Major facilitator Superfamily
K1I37_RS09930	COG0477	Major facilitator Superfamily
K1I37_RS09935	COG5002	protein histidine kinase activity
K1I37_RS09950	COG4191	Histidine kinase
K1I37_RS09955	COG0606	chelatase, subunit chli
K1I37_RS09965	COG0045	succinate-CoA ligase (ADP-forming) activity
K1I37_RS09970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K1I37_RS09975	COG0758	DNA mediated transformation
K1I37_RS09975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1I37_RS09985	COG3196	Protein conserved in bacteria
K1I37_RS10010	COG1132	(ABC) transporter
K1I37_RS10025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1I37_RS10030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K1I37_RS10035	COG4974	Belongs to the 'phage' integrase family
K1I37_RS10040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K1I37_RS10045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K1I37_RS10065	COG1766	The M ring may be actively involved in energy transduction
K1I37_RS10070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_RS10080	COG1157	protein secretion by the type III secretion system
K1I37_RS10100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K1I37_RS10110	COG4786	Flagellar basal body rod
K1I37_RS10125	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_RS10130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K1I37_RS10130	COG1776	CheC inhibitor of MCP methylation
K1I37_RS10135	COG2201	protein-glutamate methylesterase activity
K1I37_RS10145	COG1338	Plays a role in the flagellum-specific transport system
K1I37_RS10150	COG1987	bacterial-type flagellum assembly
K1I37_RS10155	COG1684	flagellar biosynthetic protein fliR
K1I37_RS10160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_RS10165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1I37_RS10170	COG1419	protein localization to endoplasmic reticulum
K1I37_RS10180	COG2201	protein-glutamate methylesterase activity
K1I37_RS10185	COG0643	Histidine kinase
K1I37_RS10185	COG2198	Histidine kinase
K1I37_RS10190	COG0835	chemotaxis
K1I37_RS10200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K1I37_RS10210	COG0052	Belongs to the universal ribosomal protein uS2 family
K1I37_RS10215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1I37_RS10220	COG0528	UMP kinase activity
K1I37_RS10225	COG0233	cytoplasmic translational termination
K1I37_RS10230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1I37_RS10235	COG4589	Belongs to the CDS family
K1I37_RS10240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K1I37_RS10245	COG0750	zinc metalloprotease
K1I37_RS10255	COG1217	gtp-binding protein TYPA
K1I37_RS10260	COG0779	Required for maturation of 30S ribosomal subunits
K1I37_RS10265	COG0195	Participates in both transcription termination and antitermination
K1I37_RS10270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K1I37_RS10285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1I37_RS10300	COG0196	riboflavin kinase activity
K1I37_RS10305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1I37_RS10310	COG1185	polyribonucleotide nucleotidyltransferase activity
K1I37_RS10315	COG0726	polysaccharide deacetylase
K1I37_RS10320	COG0612	Peptidase, M16
K1I37_RS10330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1I37_RS10335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1I37_RS10340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1I37_RS10345	COG0527	aspartate kinase activity
K1I37_RS10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1I37_RS10355	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K1I37_RS10360	COG0740	serine-type endopeptidase activity
K1I37_RS10370	COG1674	ftsk spoiiie
K1I37_RS10370	COG4980	gas vesicle protein
K1I37_RS10395	COG1426	Protein conserved in bacteria
K1I37_RS10400	COG1666	GTP binding
K1I37_RS10405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1I37_RS10410	COG1058	Belongs to the CinA family
K1I37_RS10410	COG1546	Belongs to the CinA family
K1I37_RS10420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1I37_RS10430	COG1418	mRNA catabolic process
K1I37_RS10435	COG1692	metallophosphoesterase
K1I37_RS10440	COG2359	stage V sporulation protein S
K1I37_RS10455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_RS10470	COG0681	Belongs to the peptidase S26 family
K1I37_RS10480	COG0189	ligase activity
K1I37_RS10490	COG0189	ligase activity
K1I37_RS10500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1I37_RS10510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K1I37_RS10515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1I37_RS10520	COG2136	Putative SAM-dependent methyltransferase
K1I37_RS10520	COG2521	methyltransferase
K1I37_RS10525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1I37_RS10570	COG1609	Transcriptional regulator
K1I37_RS10575	COG1653	transport
K1I37_RS10595	COG0697	spore germination
K1I37_RS10625	COG0109	protoheme IX farnesyltransferase activity
K1I37_RS10640	COG2197	response regulator
K1I37_RS10645	COG5002	protein histidine kinase activity
K1I37_RS10680	COG0464	growth
K1I37_RS10700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K1I37_RS10705	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K1I37_RS10710	COG0789	Transcriptional regulator
K1I37_RS10715	COG0174	glutamine synthetase
K1I37_RS10725	COG3267	Type II secretory pathway component ExeA
K1I37_RS10725	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_RS10745	COG0586	Pfam SNARE associated Golgi protein
K1I37_RS10750	COG0586	Pfam SNARE associated Golgi protein
K1I37_RS10785	COG4977	sequence-specific DNA binding
K1I37_RS10795	COG4166	transmembrane transport
K1I37_RS10800	COG1744	ABC transporter substrate-binding protein PnrA-like
K1I37_RS10825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K1I37_RS10835	COG0423	glycine-tRNA ligase activity
K1I37_RS10845	COG2814	Major facilitator Superfamily
K1I37_RS10850	COG0646	methionine synthase
K1I37_RS10850	COG1410	methionine synthase
K1I37_RS10855	COG0646	methionine synthase
K1I37_RS10855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K1I37_RS10865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_RS10875	COG3842	ATPase activity
K1I37_RS10890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K1I37_RS10895	COG0460	homoserine dehydrogenase
K1I37_RS10900	COG0531	amino acid
K1I37_RS10935	COG4721	ABC-type cobalt transport system, permease component
K1I37_RS10940	COG2022	thiamine diphosphate biosynthetic process
K1I37_RS10950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1I37_RS10955	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_RS10960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K1I37_RS10965	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_RS11010	COG0582	viral genome integration into host DNA
K1I37_RS11035	COG3328	transposase activity
K1I37_RS11045	COG3328	transposase activity
K1I37_RS11055	COG1247	-acetyltransferase
K1I37_RS11060	COG1247	-acetyltransferase
K1I37_RS11090	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_RS11100	COG0735	belongs to the Fur family
K1I37_RS11105	COG0450	alkyl hydroperoxide reductase
K1I37_RS11150	COG2096	Adenosyltransferase
K1I37_RS11155	COG2808	Putative FMN-binding domain
K1I37_RS11165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K1I37_RS11180	COG3328	transposase activity
K1I37_RS11185	COG0346	lactoylglutathione lyase activity
K1I37_RS11235	COG1846	Transcriptional regulator
K1I37_RS11240	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_RS11245	COG0022	dehydrogenase e1 component
K1I37_RS11250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K1I37_RS11255	COG2390	Transcriptional regulator
K1I37_RS11265	COG3732	PTS system glucitol sorbitol-specific
K1I37_RS11270	COG3730	PTS system glucitol sorbitol-specific
K1I37_RS11285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS11300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1I37_RS11305	COG0300	oxidoreductase activity
K1I37_RS11330	COG0667	Aldo Keto reductase
K1I37_RS11335	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K1I37_RS11340	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_RS11345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1I37_RS11360	COG0823	Involved in the tonB-independent uptake of proteins
K1I37_RS11360	COG1506	peptidase
K1I37_RS11360	COG4946	Tricorn protease homolog
K1I37_RS11375	COG3300	MHYT domain
K1I37_RS11375	COG5001	Diguanylate cyclase
K1I37_RS11380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1I37_RS11385	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1I37_RS11390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_RS11395	COG3935	DnaD domain protein
K1I37_RS11400	COG0017	Asparaginyl-tRNA synthetase
K1I37_RS11405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_RS11425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K1I37_RS11435	COG0402	S-adenosylhomocysteine deaminase activity
K1I37_RS11445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K1I37_RS11450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K1I37_RS11455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1I37_RS11455	COG1199	ATP-dependent helicase activity
K1I37_RS11465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K1I37_RS11465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K1I37_RS11470	COG0438	transferase activity, transferring glycosyl groups
K1I37_RS11475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1I37_RS11485	COG1694	Mazg nucleotide pyrophosphohydrolase
K1I37_RS11490	COG3314	Sporulation integral membrane protein YlbJ
K1I37_RS11495	COG1968	undecaprenyl-diphosphatase activity
K1I37_RS11500	COG3949	Membrane
K1I37_RS11505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1I37_RS11510	COG5582	Belongs to the UPF0302 family
K1I37_RS11575	COG3328	transposase activity
K1I37_RS11580	COG0287	Prephenate dehydrogenase
K1I37_RS11585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_RS11590	COG0159	tryptophan synthase activity
K1I37_RS11595	COG0133	tryptophan synthase activity
K1I37_RS11600	COG0135	phosphoribosylanthranilate isomerase activity
K1I37_RS11605	COG0134	indole-3-glycerol-phosphate synthase activity
K1I37_RS11610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K1I37_RS11615	COG4401	Chorismate mutase type I
K1I37_RS11620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K1I37_RS11625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1I37_RS11645	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS11660	COG0656	L-ascorbic acid biosynthetic process
K1I37_RS11675	COG1388	LysM domain
K1I37_RS11675	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_RS11680	COG4548	von Willebrand factor, type A
K1I37_RS11685	COG0714	Associated with various cellular activities
K1I37_RS11690	COG3706	GGDEF domain
K1I37_RS11710	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_RS11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_RS11720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K1I37_RS11725	COG0517	IMP dehydrogenase activity
K1I37_RS11735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K1I37_RS11740	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1I37_RS11745	COG0105	UTP biosynthetic process
K1I37_RS11750	COG0142	geranyltranstransferase activity
K1I37_RS11755	COG2226	methyltransferase
K1I37_RS11775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K1I37_RS11780	COG0509	glycine decarboxylation via glycine cleavage system
K1I37_RS11790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K1I37_RS11795	COG1160	GTP binding
K1I37_RS11810	COG0539	negative regulation of cytoplasmic translation
K1I37_RS11825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K1I37_RS11855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_RS11865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1I37_RS11870	COG1609	Transcriptional regulator
K1I37_RS11880	COG3328	transposase activity
K1I37_RS11900	COG0210	DNA helicase
K1I37_RS11910	COG2226	methyltransferase
K1I37_RS11920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1I37_RS11925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_RS11940	COG2339	peptidase activity
K1I37_RS11950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K1I37_RS11965	COG5002	protein histidine kinase activity
K1I37_RS11970	COG0745	RESPONSE REGULATOR receiver
K1I37_RS11980	COG1187	pseudouridine synthase activity
K1I37_RS11985	COG0700	Nucleoside recognition
K1I37_RS11990	COG2715	membrane protein required for spore maturation
K1I37_RS11995	COG3874	Sporulation protein YtfJ
K1I37_RS12005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K1I37_RS12010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K1I37_RS12015	COG1994	Peptidase M50
K1I37_RS12035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1I37_RS12045	COG1191	sigma factor activity
K1I37_RS12050	COG2172	sigma factor antagonist activity
K1I37_RS12055	COG1366	Belongs to the anti-sigma-factor antagonist family
K1I37_RS12065	COG1686	Belongs to the peptidase S11 family
K1I37_RS12070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K1I37_RS12075	COG4974	Belongs to the 'phage' integrase family
K1I37_RS12090	COG1300	Membrane
K1I37_RS12095	COG1379	DNA repair
K1I37_RS12100	COG0494	nUDIX hydrolase
K1I37_RS12105	COG1113	amino acid transport
K1I37_RS12110	COG2195	Cleaves the N-terminal amino acid of tripeptides
K1I37_RS12115	COG0321	lipoyl(octanoyl) transferase activity
K1I37_RS12120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K1I37_RS12125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_RS12130	COG0315	cyclic pyranopterin monophosphate synthase activity
K1I37_RS12135	COG0314	molybdopterin synthase activity
K1I37_RS12165	COG3253	May function as heme-dependent peroxidase
K1I37_RS12180	COG1733	regulation of RNA biosynthetic process
K1I37_RS12190	COG0750	zinc metalloprotease
K1I37_RS12195	COG0497	DNA recombination
K1I37_RS12200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K1I37_RS12210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K1I37_RS12215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1I37_RS12225	COG0142	geranyltranstransferase activity
K1I37_RS12230	COG1722	exodeoxyribonuclease VII activity
K1I37_RS12235	COG1570	exodeoxyribonuclease VII activity
K1I37_RS12240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1I37_RS12245	COG0492	ferredoxin-NADP+ reductase activity
K1I37_RS12250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1I37_RS12270	COG1302	Protein conserved in bacteria
K1I37_RS12275	COG0439	Biotin carboxylase
K1I37_RS12280	COG0511	ligase activity, forming carbon-carbon bonds
K1I37_RS12320	COG3854	ATPases associated with a variety of cellular activities
K1I37_RS12330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1I37_RS12335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K1I37_RS12340	COG0406	alpha-ribazole phosphatase activity
K1I37_RS12345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1I37_RS12350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1I37_RS12355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K1I37_RS12360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1I37_RS12370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1I37_RS12375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1I37_RS12400	COG2165	general secretion pathway protein
K1I37_RS12410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1I37_RS12420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K1I37_RS12430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1I37_RS12455	COG2894	cell division
K1I37_RS12460	COG0850	regulation of cytokinetic process
K1I37_RS12475	COG1077	Cell shape determining protein MreB Mrl
K1I37_RS12480	COG2003	Belongs to the UPF0758 family
K1I37_RS12500	COG3583	domain protein
K1I37_RS12500	COG3584	3D domain protein
K1I37_RS12505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K1I37_RS12515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1I37_RS12520	COG0285	dihydrofolate synthase activity
K1I37_RS12525	COG0525	valine-tRNA ligase activity
K1I37_RS12545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1I37_RS12550	COG0113	porphobilinogen synthase activity
K1I37_RS12560	COG0181	hydroxymethylbilane synthase activity
K1I37_RS12565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K1I37_RS12570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K1I37_RS12575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K1I37_RS12585	COG0470	DNA polymerase III
K1I37_RS12585	COG1067	ATP-dependent peptidase activity
K1I37_RS12590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1I37_RS12600	COG0544	peptidyl-prolyl cis-trans isomerase activity
K1I37_RS12620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K1I37_RS12625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K1I37_RS12630	COG1846	Transcriptional regulator
K1I37_RS12635	COG2197	response regulator
K1I37_RS12640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K1I37_RS12650	COG1054	Belongs to the UPF0176 family
K1I37_RS12665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K1I37_RS12670	COG1053	succinate dehydrogenase
K1I37_RS12675	COG2009	succinate dehydrogenase
K1I37_RS12680	COG0322	excinuclease ABC activity
K1I37_RS12705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1I37_RS12715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1I37_RS12720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K1I37_RS12730	COG0387	Pfam Sodium calcium exchanger
K1I37_RS12755	COG1316	TRANSCRIPTIONal
K1I37_RS12760	COG0463	Glycosyl transferase, family 2
K1I37_RS12775	COG2084	Dehydrogenase
K1I37_RS12780	COG1846	Transcriptional regulator
K1I37_RS12800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K1I37_RS12815	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K1I37_RS12820	COG2244	polysaccharide biosynthetic process
K1I37_RS12825	COG0671	phosphoesterase, PA-phosphatase related
K1I37_RS12830	COG2205	protein histidine kinase activity
K1I37_RS12835	COG0745	RESPONSE REGULATOR receiver
K1I37_RS12870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K1I37_RS12885	COG0205	6-phosphofructokinase activity
K1I37_RS12890	COG1064	alcohol dehydrogenase
K1I37_RS12895	COG1309	transcriptional regulator
K1I37_RS12905	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_RS12910	COG1309	transcriptional regulator
K1I37_RS12915	COG0477	Major facilitator Superfamily
K1I37_RS12930	COG0833	amino acid
K1I37_RS12935	COG3829	transcription factor binding
K1I37_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS12945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1I37_RS12950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K1I37_RS12970	COG4372	Transposase
K1I37_RS12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1I37_RS13010	COG0647	UMP catabolic process
K1I37_RS13020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_RS13035	COG2076	Multidrug Resistance protein
K1I37_RS13040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K1I37_RS13050	COG2814	Major facilitator Superfamily
K1I37_RS13055	COG1846	Transcriptional regulator
K1I37_RS13065	COG0747	negative chemotaxis
K1I37_RS13100	COG0456	acetyltransferase
K1I37_RS13105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K1I37_RS13115	COG1388	LysM domain
K1I37_RS13115	COG0791	NLP P60 protein
K1I37_RS13120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_RS13135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1I37_RS13155	COG0475	glutathione-regulated potassium exporter activity
K1I37_RS13160	COG0596	Alpha beta hydrolase
K1I37_RS13165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K1I37_RS13175	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS13180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K1I37_RS13185	COG1575	Belongs to the MenA family. Type 1 subfamily
K1I37_RS13190	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS13195	COG0598	Magnesium transport protein CorA
K1I37_RS13200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1I37_RS13235	COG0667	Aldo Keto reductase
K1I37_RS13240	COG2207	Transcriptional regulator
K1I37_RS13250	COG3328	transposase activity
K1I37_RS13255	COG1595	DNA-templated transcription, initiation
K1I37_RS13270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1I37_RS13280	COG0191	fructose-bisphosphate aldolase activity
K1I37_RS13285	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_RS13290	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_RS13295	COG0673	inositol 2-dehydrogenase activity
K1I37_RS13300	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_RS13305	COG3962	Belongs to the TPP enzyme family
K1I37_RS13310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_RS13315	COG3718	enzyme involved in inositol metabolism
K1I37_RS13325	COG2814	Major facilitator Superfamily
K1I37_RS13330	COG1349	DNA-binding transcription factor activity
K1I37_RS13340	COG3328	transposase activity
K1I37_RS13345	COG1116	anion transmembrane transporter activity
K1I37_RS13350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K1I37_RS13365	COG4372	Transposase
K1I37_RS13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K1I37_RS13380	COG2226	methyltransferase
K1I37_RS13390	COG3328	transposase activity
K1I37_RS13415	COG2271	Major facilitator Superfamily
K1I37_RS13420	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K1I37_RS13450	COG3328	transposase activity
K1I37_RS13455	COG5001	Diguanylate cyclase
K1I37_RS13480	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K1I37_RS13540	COG0697	spore germination
K1I37_RS13555	COG0531	amino acid
K1I37_RS13570	COG0406	alpha-ribazole phosphatase activity
K1I37_RS13575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K1I37_RS13580	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K1I37_RS13585	COG1120	ATPase activity
K1I37_RS13590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_RS13595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K1I37_RS13600	COG0778	Nitroreductase
K1I37_RS13610	COG1733	regulation of RNA biosynthetic process
K1I37_RS13615	COG0720	synthase
K1I37_RS13620	COG0602	queuosine metabolic process
K1I37_RS13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K1I37_RS13670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K1I37_RS13680	COG0456	acetyltransferase
K1I37_RS13690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K1I37_RS13695	COG1131	(ABC) transporter
K1I37_RS13700	COG0306	phosphate transporter
K1I37_RS13705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K1I37_RS13755	COG2814	Major facilitator Superfamily
K1I37_RS13760	COG0300	oxidoreductase activity
K1I37_RS13770	COG1940	carbohydrate kinase activity
K1I37_RS13775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1I37_RS13780	COG2176	DNA-directed DNA polymerase activity
K1I37_RS13785	COG1346	cytolysis
K1I37_RS13800	COG2814	Major facilitator Superfamily
K1I37_RS13805	COG5577	PFAM Coat F domain
K1I37_RS13820	COG0697	spore germination
K1I37_RS13835	COG0456	acetyltransferase
K1I37_RS13835	COG1846	Transcriptional regulator
K1I37_RS13840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1I37_RS13845	COG0789	Transcriptional regulator
K1I37_RS13850	COG1247	-acetyltransferase
K1I37_RS13865	COG3328	transposase activity
K1I37_RS13880	COG4372	Transposase
K1I37_RS13910	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_RS13910	COG3267	Type II secretory pathway component ExeA
K1I37_RS13920	COG3328	transposase activity
K1I37_RS13930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K1I37_RS13935	COG1131	(ABC) transporter
K1I37_RS13945	COG1131	(ABC) transporter
K1I37_RS13950	COG1725	Transcriptional regulator
K1I37_RS13965	COG0431	NADPH-dependent FMN reductase
K1I37_RS13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_RS13990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_RS13995	COG0454	-acetyltransferase
K1I37_RS14000	COG2226	methyltransferase
K1I37_RS14005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_RS14010	COG0385	Bile acid
K1I37_RS14020	COG0024	Methionine aminopeptidase
K1I37_RS14025	COG0242	peptide deformylase activity
K1I37_RS14030	COG4106	trans-aconitate 2-methyltransferase activity
K1I37_RS14055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K1I37_RS14070	COG1414	Transcriptional regulator
K1I37_RS14085	COG1414	Transcriptional regulator
K1I37_RS14090	COG2814	Major facilitator Superfamily
K1I37_RS14095	COG0454	-acetyltransferase
K1I37_RS14135	COG1121	(ABC) transporter
K1I37_RS14150	COG0523	cobalamin synthesis protein
K1I37_RS14155	COG0735	belongs to the Fur family
K1I37_RS14170	COG0488	(ABC) transporter
K1I37_RS14175	COG0488	(ABC) transporter
K1I37_RS14195	COG0069	glutamate synthase activity
K1I37_RS14240	COG0395	ABC-type sugar transport system, permease component
K1I37_RS14245	COG1175	transmembrane transport
K1I37_RS14260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_RS14285	COG2814	Major facilitator Superfamily
K1I37_RS14290	COG3328	transposase activity
K1I37_RS14305	COG0840	transmembrane signaling receptor activity
K1I37_RS14310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K1I37_RS14335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_RS14340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_RS14350	COG0747	negative chemotaxis
K1I37_RS14360	COG0425	Belongs to the sulfur carrier protein TusA family
K1I37_RS14365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1I37_RS14365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1I37_RS14370	COG2210	Belongs to the sulfur carrier protein TusA family
K1I37_RS14380	COG1937	Protein conserved in bacteria
K1I37_RS14390	COG1335	isochorismatase
K1I37_RS14400	COG0517	IMP dehydrogenase activity
K1I37_RS14410	COG2814	Major facilitator Superfamily
K1I37_RS14420	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K1I37_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS14435	COG3328	transposase activity
K1I37_RS14460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_RS14465	COG1846	Transcriptional regulator
K1I37_RS14490	COG3328	transposase activity
K1I37_RS14500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K1I37_RS14505	COG2384	SAM-dependent methyltransferase
K1I37_RS14515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1I37_RS14520	COG0358	DNA primase activity
K1I37_RS14525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1I37_RS14540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1I37_RS14550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1I37_RS14555	COG1480	7TM receptor with intracellular HD hydrolase
K1I37_RS14560	COG1702	phosphate starvation-inducible protein PhoH
K1I37_RS14575	COG1610	YqeY-like protein
K1I37_RS14580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K1I37_RS14585	COG1283	sodium-dependent phosphate transmembrane transporter activity
K1I37_RS14590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K1I37_RS14595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1I37_RS14600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1I37_RS14605	COG2264	protein methyltransferase activity
K1I37_RS14615	COG0443	Heat shock 70 kDa protein
K1I37_RS14620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K1I37_RS14625	COG1420	regulation of RNA biosynthetic process
K1I37_RS14630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K1I37_RS14635	COG0481	GTPase activity
K1I37_RS14650	COG1196	nuclear chromosome segregation
K1I37_RS14650	COG0739	heme binding
K1I37_RS14650	COG0741	lytic transglycosylase activity
K1I37_RS14655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K1I37_RS14660	COG0268	Binds directly to 16S ribosomal RNA
K1I37_RS14670	COG1466	dna polymerase III delta subunit
K1I37_RS14675	COG1252	NADH dehydrogenase
K1I37_RS14690	COG1321	iron dependent repressor
K1I37_RS14695	COG2226	methyltransferase
K1I37_RS14700	COG0799	negative regulation of ribosome biogenesis
K1I37_RS14705	COG1713	HD superfamily hydrolase involved in NAD metabolism
K1I37_RS14710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K1I37_RS14715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K1I37_RS14720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K1I37_RS14725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K1I37_RS14735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_RS14775	COG3584	3D domain protein
K1I37_RS14775	COG1388	LysM domain
K1I37_RS14815	COG0756	dUTP diphosphatase activity
K1I37_RS15000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1I37_RS15120	COG0270	DNA (cytosine-5-)-methyltransferase activity
K1I37_RS15215	COG0739	heme binding
K1I37_RS15245	COG0740	serine-type endopeptidase activity
K1I37_RS15360	COG0393	Putative heavy-metal-binding
K1I37_RS15370	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_RS15370	COG1388	LysM domain
K1I37_RS15465	COG0768	penicillin binding
K1I37_RS15470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K1I37_RS15475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K1I37_RS15480	COG4472	Bacterial protein of unknown function (DUF965)
K1I37_RS15495	COG0628	permease
K1I37_RS15500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_RS15505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_RS15515	COG1104	cysteine desulfurase activity
K1I37_RS15520	COG1959	2 iron, 2 sulfur cluster binding
K1I37_RS15530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1I37_RS15535	COG0124	histidyl-tRNA synthetase
K1I37_RS15550	COG4405	Protein conserved in bacteria
K1I37_RS15555	COG0833	amino acid
K1I37_RS15560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1I37_RS15565	COG1846	Transcriptional regulator
K1I37_RS15570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1I37_RS15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1I37_RS15580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_RS15580	COG4499	WXG100 protein secretion system (Wss), protein YukC
K1I37_RS15585	COG0028	Belongs to the TPP enzyme family
K1I37_RS15590	COG1595	DNA-templated transcription, initiation
K1I37_RS15625	COG0477	Major facilitator Superfamily
K1I37_RS15630	COG0583	DNA-binding transcription factor activity
K1I37_RS15635	COG0386	Belongs to the glutathione peroxidase family
K1I37_RS15640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1I37_RS15655	COG0517	IMP dehydrogenase activity
K1I37_RS15660	COG0574	Belongs to the PEP-utilizing enzyme family
K1I37_RS15660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_RS15665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1I37_RS15670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K1I37_RS15705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K1I37_RS15715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1I37_RS15715	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K1I37_RS15720	COG0039	L-malate dehydrogenase activity
K1I37_RS15725	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS15755	COG0667	Aldo Keto reductase
K1I37_RS15760	COG0303	'Molybdopterin
K1I37_RS15770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1I37_RS15775	COG1074	ATP-dependent DNA helicase activity
K1I37_RS15780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K1I37_RS15785	COG4717	serine-type aminopeptidase activity
K1I37_RS15795	COG0477	Major facilitator Superfamily
K1I37_RS15815	COG3239	Fatty acid desaturase
K1I37_RS15820	COG1278	Cold shock
K1I37_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS15840	COG2814	Major facilitator Superfamily
K1I37_RS15845	COG4191	Histidine kinase
K1I37_RS15850	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS15900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_RS15905	COG0477	Major facilitator Superfamily
K1I37_RS15920	COG0681	Belongs to the peptidase S26 family
K1I37_RS15925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1I37_RS15935	COG1686	Belongs to the peptidase S11 family
K1I37_RS15955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K1I37_RS15960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1I37_RS15965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K1I37_RS15980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_RS15995	COG5001	Diguanylate cyclase
K1I37_RS16010	COG1490	D-aminoacyl-tRNA deacylase activity
K1I37_RS16015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1I37_RS16020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1I37_RS16025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1I37_RS16025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K1I37_RS16030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K1I37_RS16035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_RS16040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1I37_RS16050	COG2244	polysaccharide biosynthetic process
K1I37_RS16055	COG2323	membrane
K1I37_RS16075	COG0343	queuine tRNA-ribosyltransferase activity
K1I37_RS16080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K1I37_RS16100	COG3693	PFAM glycoside hydrolase, family 10
K1I37_RS16105	COG1191	sigma factor activity
K1I37_RS16110	COG2255	four-way junction helicase activity
K1I37_RS16115	COG0632	four-way junction helicase activity
K1I37_RS16120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K1I37_RS16130	COG0217	transcriptional regulatory protein
K1I37_RS16165	COG4499	WXG100 protein secretion system (Wss), protein YukC
K1I37_RS16165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1I37_RS16170	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS16175	COG1193	negative regulation of DNA recombination
K1I37_RS16190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K1I37_RS16195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1I37_RS16195	COG0072	phenylalanine-tRNA ligase activity
K1I37_RS16200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1I37_RS16215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_RS16220	COG0601	transmembrane transport
K1I37_RS16235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1I37_RS16240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K1I37_RS16245	COG1830	Aldolase
K1I37_RS16250	COG0205	6-phosphofructokinase activity
K1I37_RS16255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K1I37_RS16260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS16265	COG3842	ATPase activity
K1I37_RS16270	COG3835	regulator
K1I37_RS16285	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_RS16290	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1I37_RS16295	COG0567	Dehydrogenase, E1 component
K1I37_RS16305	COG0714	Associated with various cellular activities
K1I37_RS16320	COG1482	cell wall glycoprotein biosynthetic process
K1I37_RS16325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1I37_RS16335	COG0673	inositol 2-dehydrogenase activity
K1I37_RS16340	COG0673	inositol 2-dehydrogenase activity
K1I37_RS16345	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_RS16355	COG1082	Xylose isomerase domain protein TIM barrel
K1I37_RS16355	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K1I37_RS16365	COG3546	catalase activity
K1I37_RS16380	COG3344	reverse transcriptase
K1I37_RS16385	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K1I37_RS16395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1I37_RS16400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1I37_RS16405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1I37_RS16410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1I37_RS16415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1I37_RS16435	COG2814	Major facilitator Superfamily
K1I37_RS16440	COG1846	Transcriptional regulator
K1I37_RS16445	COG3328	transposase activity
K1I37_RS16515	COG0739	heme binding
K1I37_RS16565	COG3239	Fatty acid desaturase
K1I37_RS16570	COG1278	Cold shock
K1I37_RS16595	COG4372	Transposase
K1I37_RS16615	COG5002	protein histidine kinase activity
K1I37_RS16625	COG1388	LysM domain
K1I37_RS16635	COG1819	glycosyl
K1I37_RS16650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_RS16680	COG3328	transposase activity
K1I37_RS16700	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_RS16740	COG0840	transmembrane signaling receptor activity
K1I37_RS16750	COG0604	alcohol dehydrogenase
K1I37_RS16755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K1I37_RS16790	COG1278	Cold shock
K1I37_RS16815	COG1278	Cold shock
K1I37_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS16850	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_RS16890	COG5577	PFAM Coat F domain
K1I37_RS16895	COG2814	Major facilitator Superfamily
K1I37_RS16905	COG2267	carboxylic ester hydrolase activity
K1I37_RS16955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K1I37_RS16965	COG0438	transferase activity, transferring glycosyl groups
K1I37_RS16975	COG0501	Belongs to the peptidase M48B family
K1I37_RS16980	COG0577	efflux transmembrane transporter activity
K1I37_RS16985	COG1136	(ABC) transporter
K1I37_RS17005	COG0517	IMP dehydrogenase activity
K1I37_RS17020	COG0372	Belongs to the citrate synthase family
K1I37_RS17025	COG1971	Probably functions as a manganese efflux pump
K1I37_RS17030	COG0285	dihydrofolate synthase activity
K1I37_RS17035	COG0066	3-isopropylmalate dehydratase activity
K1I37_RS17040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K1I37_RS17045	COG0473	3-isopropylmalate dehydrogenase activity
K1I37_RS17050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1I37_RS17055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K1I37_RS17060	COG0440	acetolactate synthase activity
K1I37_RS17065	COG0028	Belongs to the TPP enzyme family
K1I37_RS17070	COG0129	dihydroxy-acid dehydratase activity
K1I37_RS17075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K1I37_RS17080	COG0460	homoserine dehydrogenase
K1I37_RS17085	COG1607	acyl-coa hydrolase
K1I37_RS17090	COG0745	RESPONSE REGULATOR receiver
K1I37_RS17095	COG1959	2 iron, 2 sulfur cluster binding
K1I37_RS17100	COG1017	nitric oxide dioxygenase activity
K1I37_RS17100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K1I37_RS17115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K1I37_RS17120	COG0352	thiamine-phosphate diphosphorylase activity
K1I37_RS17120	COG0351	phosphomethylpyrimidine kinase
K1I37_RS17150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1I37_RS17155	COG2217	Heavy metal translocating P-type atpase
K1I37_RS17160	COG1937	Protein conserved in bacteria
K1I37_RS17165	COG2608	mercury ion transmembrane transporter activity
K1I37_RS17170	COG0671	phosphoesterase, PA-phosphatase related
K1I37_RS17190	COG1595	DNA-templated transcription, initiation
K1I37_RS17195	COG1388	LysM domain
K1I37_RS17195	COG3858	chitin binding
K1I37_RS17210	COG1132	(ABC) transporter
K1I37_RS17215	COG1132	(ABC) transporter
K1I37_RS17220	COG1757	Na H antiporter
K1I37_RS17230	COG2814	Major facilitator Superfamily
K1I37_RS17235	COG2814	Major facilitator Superfamily
K1I37_RS17240	COG0745	RESPONSE REGULATOR receiver
K1I37_RS17245	COG5002	protein histidine kinase activity
K1I37_RS17250	COG0095	Lipoate-protein ligase
K1I37_RS17255	COG0583	DNA-binding transcription factor activity
K1I37_RS17265	COG2132	Multicopper oxidase
K1I37_RS17280	COG2390	Transcriptional regulator
K1I37_RS17295	COG1072	(Pantothenic acid kinase))
K1I37_RS17335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1I37_RS17340	COG3619	membrane
K1I37_RS17345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K1I37_RS17360	COG1802	Transcriptional regulator
K1I37_RS17365	COG1069	ribulokinase activity
K1I37_RS17375	COG2814	Major facilitator Superfamily
K1I37_RS17390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K1I37_RS17395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K1I37_RS17400	COG1879	ABC-type sugar transport system periplasmic component
K1I37_RS17405	COG1172	Belongs to the binding-protein-dependent transport system permease family
K1I37_RS17415	COG1869	D-ribose catabolic process
K1I37_RS17420	COG1609	Transcriptional regulator
K1I37_RS17425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_RS17430	COG0402	S-adenosylhomocysteine deaminase activity
K1I37_RS17435	COG2195	Cleaves the N-terminal amino acid of tripeptides
K1I37_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS17450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K1I37_RS17460	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1I37_RS17465	COG3829	transcription factor binding
K1I37_RS17465	COG3290	protein histidine kinase activity
K1I37_RS17475	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS17480	COG1454	alcohol dehydrogenase
K1I37_RS17490	COG1228	amidohydrolase
K1I37_RS17500	COG4821	SIS domain
K1I37_RS17520	COG3716	PTS system mannose fructose sorbose family IID component
K1I37_RS17530	COG2188	Transcriptional regulator
K1I37_RS17535	COG0604	alcohol dehydrogenase
K1I37_RS17540	COG1929	Belongs to the glycerate kinase type-1 family
K1I37_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS17565	COG0183	Belongs to the thiolase family
K1I37_RS17590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K1I37_RS17610	COG1228	amidohydrolase
K1I37_RS17615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K1I37_RS17665	COG2271	Major facilitator Superfamily
K1I37_RS17680	COG0662	Cupin 2, conserved barrel domain protein
K1I37_RS17700	COG4372	Transposase
K1I37_RS17710	COG0531	amino acid
K1I37_RS17715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K1I37_RS17720	COG3153	acetyltransferase
K1I37_RS17720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_RS17725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K1I37_RS17735	COG3290	protein histidine kinase activity
K1I37_RS17735	COG3829	transcription factor binding
K1I37_RS17740	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS17750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K1I37_RS17755	COG0686	Belongs to the AlaDH PNT family
K1I37_RS17775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1I37_RS17780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K1I37_RS17785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K1I37_RS17790	COG2079	MmgE PrpD family protein
K1I37_RS17795	COG2814	Major facilitator Superfamily
K1I37_RS17805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K1I37_RS17810	COG1414	Transcriptional regulator
K1I37_RS17820	COG1063	alcohol dehydrogenase
K1I37_RS17835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K1I37_RS17845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K1I37_RS17860	COG1335	isochorismatase
K1I37_RS17865	COG0673	inositol 2-dehydrogenase activity
K1I37_RS17875	COG0395	ABC-type sugar transport system, permease component
K1I37_RS17880	COG1175	transmembrane transport
K1I37_RS17895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K1I37_RS17905	COG1349	DNA-binding transcription factor activity
K1I37_RS17920	COG1472	Belongs to the glycosyl hydrolase 3 family
K1I37_RS17925	COG0395	ABC-type sugar transport system, permease component
K1I37_RS17955	COG3385	transposase activity
K1I37_RS17960	COG1253	flavin adenine dinucleotide binding
K1I37_RS17975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1I37_RS17980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K1I37_RS17995	COG0768	penicillin binding
K1I37_RS18000	COG0776	regulation of translation
K1I37_RS18045	COG2259	Doxx family
K1I37_RS18050	COG1063	alcohol dehydrogenase
K1I37_RS18055	COG1940	carbohydrate kinase activity
K1I37_RS18070	COG2207	Transcriptional regulator
K1I37_RS18080	COG0531	amino acid
K1I37_RS18095	COG0741	lytic transglycosylase activity
K1I37_RS18100	COG0237	dephospho-CoA kinase activity
K1I37_RS18110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_RS18110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_RS18120	COG0538	isocitrate dehydrogenase activity
K1I37_RS18130	COG0745	RESPONSE REGULATOR receiver
K1I37_RS18135	COG0180	Tryptophanyl-tRNA synthetase
K1I37_RS18145	COG0825	malonyl-CoA metabolic process
K1I37_RS18150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1I37_RS18160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1I37_RS18165	COG0587	DNA-directed DNA polymerase activity
K1I37_RS18170	COG4109	DRTGG domain
K1I37_RS18175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K1I37_RS18195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K1I37_RS18200	COG1438	arginine binding
K1I37_RS18205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_RS18220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K1I37_RS18225	COG3679	Belongs to the UPF0342 family
K1I37_RS18230	COG2346	COG2346, Truncated hemoglobins
K1I37_RS18240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K1I37_RS18245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K1I37_RS18265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1I37_RS18275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1I37_RS18275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1I37_RS18285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1I37_RS18285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1I37_RS18290	COG1045	serine acetyltransferase
K1I37_RS18305	COG4496	protein, YerC YecD
K1I37_RS18340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1I37_RS18355	COG5002	protein histidine kinase activity
K1I37_RS18360	COG0745	RESPONSE REGULATOR receiver
K1I37_RS18365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K1I37_RS18375	COG0805	protein transport
K1I37_RS18380	COG2271	Major facilitator Superfamily
K1I37_RS18385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1I37_RS18390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K1I37_RS18400	COG3328	transposase activity
K1I37_RS18405	COG3290	protein histidine kinase activity
K1I37_RS18405	COG3829	transcription factor binding
K1I37_RS18420	COG0517	IMP dehydrogenase activity
K1I37_RS18420	COG1125	glycine betaine transport
K1I37_RS18425	COG1063	alcohol dehydrogenase
K1I37_RS18430	COG1960	acyl-CoA dehydrogenase activity
K1I37_RS18440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1I37_RS18450	COG1902	pentaerythritol trinitrate reductase activity
K1I37_RS18450	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1I37_RS18455	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS18465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K1I37_RS18490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K1I37_RS18495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1I37_RS18505	COG3386	PFAM SMP-30 Gluconolaconase
K1I37_RS18515	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_RS18530	COG1846	Transcriptional regulator
K1I37_RS18535	COG0477	Major facilitator Superfamily
K1I37_RS18540	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_RS18545	COG2814	Major facilitator Superfamily
K1I37_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS18570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1I37_RS18590	COG0667	Aldo Keto reductase
K1I37_RS18620	COG0788	formyltetrahydrofolate deformylase activity
K1I37_RS18640	COG1587	Uroporphyrinogen-III synthase
K1I37_RS18640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_RS18645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K1I37_RS18650	COG0175	sulfate reduction
K1I37_RS18655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K1I37_RS18655	COG1648	precorrin-2 dehydrogenase activity
K1I37_RS18660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_RS18660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1I37_RS18670	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_RS18675	COG2814	Major facilitator Superfamily
K1I37_RS18680	COG1566	PFAM secretion protein HlyD family protein
K1I37_RS18685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K1I37_RS18695	COG1376	ErfK ybiS ycfS ynhG family protein
K1I37_RS18700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K1I37_RS18700	COG2755	lipolytic protein G-D-S-L family
K1I37_RS18710	COG1164	Oligoendopeptidase f
K1I37_RS18715	COG0445	tRNA wobble uridine modification
K1I37_RS18730	COG1216	Glycosyl transferase, family 2
K1I37_RS18735	COG2814	Major facilitator Superfamily
K1I37_RS18740	COG1233	COG1233 Phytoene dehydrogenase and related
K1I37_RS18750	COG1562	ergosterol biosynthetic process
K1I37_RS18755	COG1657	PFAM Prenyltransferase squalene oxidase
K1I37_RS18760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1I37_RS18775	COG1304	FMN binding
K1I37_RS18780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1I37_RS18790	COG3135	benzoate transporter
K1I37_RS18795	COG0583	DNA-binding transcription factor activity
K1I37_RS18800	COG0163	prenyltransferase activity
K1I37_RS18805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K1I37_RS18825	COG0514	ATP-dependent DNA helicase (RecQ)
K1I37_RS18850	COG1388	LysM domain
K1I37_RS18850	COG3858	chitin binding
K1I37_RS18855	COG3328	transposase activity
K1I37_RS18860	COG0697	spore germination
K1I37_RS18865	COG1902	pentaerythritol trinitrate reductase activity
K1I37_RS18870	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS18880	COG2814	Major facilitator Superfamily
K1I37_RS18885	COG0363	glucosamine-6-phosphate deaminase activity
K1I37_RS18890	COG0531	amino acid
K1I37_RS18935	COG0517	IMP dehydrogenase activity
K1I37_RS18935	COG1125	glycine betaine transport
K1I37_RS18950	COG4336	lyase activity
K1I37_RS18960	COG1914	H( )-stimulated, divalent metal cation uptake system
K1I37_RS19005	COG4372	Transposase
K1I37_RS19030	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS19035	COG0183	Belongs to the thiolase family
K1I37_RS19040	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_RS19045	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1I37_RS19050	COG1024	Enoyl-CoA hydratase
K1I37_RS19065	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K1I37_RS19070	COG2151	metal-sulfur cluster biosynthetic enzyme
K1I37_RS19085	COG1024	Enoyl-CoA hydratase
K1I37_RS19090	COG3396	Phenylacetate-CoA oxygenase
K1I37_RS19095	COG1309	transcriptional regulator
K1I37_RS19100	COG3328	transposase activity
K1I37_RS19110	COG1476	TRANSCRIPTIONal
K1I37_RS19125	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K1I37_RS19160	COG4372	Transposase
K1I37_RS19190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K1I37_RS19195	COG1984	allophanate hydrolase subunit 2
K1I37_RS19200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K1I37_RS19205	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS19210	COG1312	Catalyzes the dehydration of D-mannonate
K1I37_RS19215	COG0800	Aldolase
K1I37_RS19220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_RS19225	COG2814	Major facilitator Superfamily
K1I37_RS19245	COG0395	ABC-type sugar transport system, permease component
K1I37_RS19250	COG1175	transmembrane transport
K1I37_RS19270	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K1I37_RS19290	COG0436	Aminotransferase
K1I37_RS19295	COG1846	Transcriptional regulator
K1I37_RS19300	COG1764	response to oxidative stress
K1I37_RS19355	COG0583	DNA-binding transcription factor activity
K1I37_RS19365	COG3328	transposase activity
K1I37_RS19375	COG0747	negative chemotaxis
K1I37_RS19380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1I37_RS19385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1I37_RS19390	COG1780	Probably involved in ribonucleotide reductase function
K1I37_RS19395	COG3384	dioxygenase
K1I37_RS19400	COG0655	NAD(P)H dehydrogenase (quinone) activity
K1I37_RS19435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1I37_RS19445	COG0577	efflux transmembrane transporter activity
K1I37_RS19460	COG5002	protein histidine kinase activity
K1I37_RS19465	COG0745	RESPONSE REGULATOR receiver
K1I37_RS19475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K1I37_RS19485	COG0653	protein targeting
K1I37_RS19490	COG1215	transferase activity, transferring glycosyl groups
K1I37_RS19510	COG1516	flagellar protein fliS
K1I37_RS19520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K1I37_RS19530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K1I37_RS19535	COG1256	bacterial-type flagellum assembly
K1I37_RS19535	COG4786	Flagellar basal body rod
K1I37_RS19565	COG5002	protein histidine kinase activity
K1I37_RS19570	COG0745	RESPONSE REGULATOR receiver
K1I37_RS19590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1I37_RS19595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K1I37_RS19610	COG2814	Major facilitator Superfamily
K1I37_RS19615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1I37_RS19620	COG0412	Dienelactone hydrolase
K1I37_RS19625	COG0521	Mo-molybdopterin cofactor biosynthetic process
K1I37_RS19625	COG0315	cyclic pyranopterin monophosphate synthase activity
K1I37_RS19630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K1I37_RS19655	COG1609	Transcriptional regulator
K1I37_RS19675	COG2160	L-arabinose isomerase activity
K1I37_RS19695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K1I37_RS19775	COG0384	phenazine biosynthesis protein PhzF
K1I37_RS19780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1I37_RS19790	COG1187	pseudouridine synthase activity
K1I37_RS19795	COG2258	MOSC domain
K1I37_RS19815	COG4608	Belongs to the ABC transporter superfamily
K1I37_RS19840	COG1609	Transcriptional regulator
K1I37_RS19845	COG2723	6-phospho-beta-galactosidase activity
K1I37_RS19850	COG4608	Belongs to the ABC transporter superfamily
K1I37_RS19875	COG1609	Transcriptional regulator
K1I37_RS19880	COG0306	phosphate transporter
K1I37_RS19885	COG1392	Phosphate transport regulator
K1I37_RS19890	COG0833	amino acid
K1I37_RS19900	COG0667	Aldo Keto reductase
K1I37_RS19915	COG1113	amino acid transport
K1I37_RS19920	COG2188	Transcriptional regulator
K1I37_RS19930	COG0318	PFAM AMP-dependent synthetase and ligase
K1I37_RS19935	COG2814	Major facilitator Superfamily
K1I37_RS19950	COG1809	phosphosulfolactate synthase activity
K1I37_RS19960	COG0531	amino acid
K1I37_RS19965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_RS19970	COG0400	carboxylic ester hydrolase activity
K1I37_RS19980	COG1793	dna ligase
K1I37_RS19985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1I37_RS19990	COG3285	dna ligase
K1I37_RS19990	COG1793	dna ligase
K1I37_RS20000	COG0488	(ABC) transporter
K1I37_RS20005	COG4895	conserved protein (DUF2196)
K1I37_RS20030	COG2076	Multidrug Resistance protein
K1I37_RS20050	COG0395	ABC-type sugar transport system, permease component
K1I37_RS20060	COG0584	glycerophosphoryl diester phosphodiesterase
K1I37_RS20080	COG1227	inorganic diphosphatase activity
K1I37_RS20090	COG1388	LysM domain
K1I37_RS20090	COG1705	Flagellar rod assembly protein muramidase FlgJ
K1I37_RS20250	COG1132	(ABC) transporter
K1I37_RS20255	COG1132	(ABC) transporter
K1I37_RS20260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1I37_RS20265	COG0561	phosphatase activity
K1I37_RS20270	COG2720	vancomycin resistance protein
K1I37_RS20290	COG1733	regulation of RNA biosynthetic process
K1I37_RS20295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K1I37_RS20300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K1I37_RS20305	COG1012	belongs to the aldehyde dehydrogenase family
K1I37_RS20315	COG0166	Belongs to the GPI family
K1I37_RS20325	COG4191	Histidine kinase
K1I37_RS20355	COG0745	RESPONSE REGULATOR receiver
K1I37_RS20360	COG2205	protein histidine kinase activity
K1I37_RS20370	COG2814	Major facilitator Superfamily
K1I37_RS20375	COG1733	regulation of RNA biosynthetic process
K1I37_RS20395	COG4585	Histidine kinase
K1I37_RS20400	COG2197	response regulator
K1I37_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
K1I37_RS20425	COG0789	Transcriptional regulator
K1I37_RS20430	COG5609	conserved protein (DUF2294)
K1I37_RS20435	COG3002	Belongs to the UPF0753 family
K1I37_RS20440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1I37_RS20450	COG4372	Transposase
K1I37_RS20485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_RS20490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1I37_RS20500	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS20515	COG1120	ATPase activity
K1I37_RS20525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1I37_RS20530	COG0246	Mannitol dehydrogenase
K1I37_RS20540	COG3711	transcriptional antiterminator
K1I37_RS20545	COG2213	PTS system mannitol-specific
K1I37_RS20560	COG5002	protein histidine kinase activity
K1I37_RS20565	COG2814	Major facilitator Superfamily
K1I37_RS20605	COG1476	TRANSCRIPTIONal
K1I37_RS20610	COG3409	Peptidoglycan-binding domain 1 protein
K1I37_RS20610	COG3267	Type II secretory pathway component ExeA
K1I37_RS20635	COG3328	transposase activity
K1I37_RS20670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K1I37_RS20685	COG4372	Transposase
K1I37_RS20695	COG0653	protein targeting
K1I37_RS20705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K1I37_RS20710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1I37_RS20715	COG0321	lipoyl(octanoyl) transferase activity
K1I37_RS20715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K1I37_RS20730	COG5002	protein histidine kinase activity
K1I37_RS20745	COG0305	Participates in initiation and elongation during chromosome replication
K1I37_RS20750	COG0359	binds to the 23S rRNA
K1I37_RS20765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K1I37_RS20770	COG0629	single-stranded DNA binding
K1I37_RS20780	COG0012	GTP binding
K1I37_RS20785	COG0243	molybdopterin cofactor binding
K1I37_RS20790	COG4481	Protein conserved in bacteria
K1I37_RS20795	COG0668	transmembrane transport
K1I37_RS20815	COG1811	Na channel or pump
K1I37_RS20820	COG1475	DNA binding
K1I37_RS20825	COG1192	Involved in chromosome partitioning
K1I37_RS20830	COG1475	DNA binding
K1I37_RS20835	COG0357	Ribosomal RNA small subunit methyltransferase G
K1I37_RS20840	COG0445	tRNA wobble uridine modification
K1I37_RS20845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K1I37_RS20850	COG1847	R3H domain protein
K1I37_RS20855	COG0706	membrane insertase activity
K1I37_RS20860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K1I37_RS20870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K1I37_RS20925	COG2002	toxin-antitoxin pair type II binding
K1I37_RS20935	COG0629	single-stranded DNA binding
K1I37_RS20985	COG0592	DNA-directed DNA polymerase activity
K1I37_RS21070	COG1061	Type III restriction enzyme res subunit
K1I37_RS21090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1I37_RS21105	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS21150	COG1192	Involved in chromosome partitioning
K1I37_RS21175	COG2200	EAL domain
K1I37_RS21240	COG3328	transposase activity
K1I37_RS21245	COG3547	Transposase (IS116 IS110 IS902 family)
K1I37_RS21250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1I37_RS21265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K1I37_RS21265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1I37_RS21290	COG0210	DNA helicase
K1I37_RS21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1I37_RS21390	COG0697	spore germination
K1I37_RS21400	COG4221	oxidoreductase activity
K1I37_RS21405	COG3328	transposase activity
K1I37_RS21435	COG4962	Type ii secretion system protein e