locus-tag	class	description
FY534_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY534_RS00010	COG0592	DNA-directed DNA polymerase activity
FY534_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY534_RS00030	COG0187	DNA topoisomerase II activity
FY534_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY534_RS00055	COG0517	IMP dehydrogenase activity
FY534_RS00055	COG0516	GMP reductase activity
FY534_RS00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FY534_RS00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FY534_RS00085	COG0582	viral genome integration into host DNA
FY534_RS00125	COG0556	nucleotide-excision repair
FY534_RS00145	COG1403	HNH endonuclease
FY534_RS00155	COG0651	ATP synthesis coupled electron transport
FY534_RS00160	COG0650	Formate hydrogenlyase subunit 4
FY534_RS00170	COG0651	ATP synthesis coupled electron transport
FY534_RS00175	COG3261	NADH dehydrogenase
FY534_RS00175	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FY534_RS00185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS00200	COG0583	DNA-binding transcription factor activity
FY534_RS00235	COG1960	acyl-CoA dehydrogenase activity
FY534_RS00250	COG2267	carboxylic ester hydrolase activity
FY534_RS00255	COG4187	Peptidase family M20/M25/M40
FY534_RS00260	COG0667	Aldo Keto reductase
FY534_RS00270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY534_RS00280	COG2267	carboxylic ester hydrolase activity
FY534_RS00290	COG2124	cytochrome p450
FY534_RS00295	COG0166	Belongs to the GPI family
FY534_RS00300	COG1940	carbohydrate kinase activity
FY534_RS00315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY534_RS00335	COG0735	belongs to the Fur family
FY534_RS00345	COG1121	(ABC) transporter
FY534_RS00360	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FY534_RS00375	COG0395	ABC-type sugar transport system, permease component
FY534_RS00380	COG3250	beta-galactosidase activity
FY534_RS00385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY534_RS00390	COG0657	acetylesterase activity
FY534_RS00395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FY534_RS00400	COG1850	ribulose-bisphosphate carboxylase activity
FY534_RS00405	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FY534_RS00410	COG0235	Class ii aldolase
FY534_RS00415	COG0367	asparagine synthase
FY534_RS00430	COG0590	tRNA wobble adenosine to inosine editing
FY534_RS00460	COG3852	Histidine kinase
FY534_RS00465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY534_RS00470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY534_RS00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY534_RS00490	COG2244	polysaccharide biosynthetic process
FY534_RS00500	COG1982	Orn Lys Arg decarboxylase major
FY534_RS00505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY534_RS00510	COG3870	Protein conserved in bacteria
FY534_RS00515	COG0470	DNA polymerase III
FY534_RS00520	COG1774	PSP1 C-terminal conserved region
FY534_RS00525	COG4467	Involved in initiation control of chromosome replication
FY534_RS00530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY534_RS00535	COG2002	toxin-antitoxin pair type II binding
FY534_RS00560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY534_RS00580	COG0084	hydrolase, TatD family'
FY534_RS00585	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FY534_RS00590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY534_RS00605	COG4466	Protein conserved in bacteria
FY534_RS00615	COG0189	ligase activity
FY534_RS00615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY534_RS00620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY534_RS00625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY534_RS00630	COG0251	oxidation-reduction process
FY534_RS00635	COG2088	sporulation resulting in formation of a cellular spore
FY534_RS00640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY534_RS00650	COG0193	aminoacyl-tRNA hydrolase activity
FY534_RS00660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY534_RS00665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY534_RS00670	COG2002	toxin-antitoxin pair type II binding
FY534_RS00675	COG2244	polysaccharide biosynthetic process
FY534_RS00680	COG3956	TIGRFAM MazG family protein
FY534_RS00690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FY534_RS00710	COG1098	S1 RNA binding domain
FY534_RS00715	COG3344	reverse transcriptase
FY534_RS00725	COG2131	deaminase
FY534_RS00730	COG2208	phosphoserine phosphatase activity
FY534_RS00735	COG2304	oxidoreductase activity
FY534_RS00745	COG0037	tRNA processing
FY534_RS00750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FY534_RS00755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY534_RS00760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FY534_RS00765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY534_RS00770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY534_RS00775	COG1396	sequence-specific DNA binding
FY534_RS00780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY534_RS00785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY534_RS00825	COG0243	molybdopterin cofactor binding
FY534_RS00830	COG2211	Major facilitator Superfamily
FY534_RS00860	COG2323	membrane
FY534_RS00865	COG1960	acyl-CoA dehydrogenase activity
FY534_RS00875	COG0477	Major facilitator Superfamily
FY534_RS00880	COG1846	Transcriptional regulator
FY534_RS00885	COG0277	FAD linked oxidase domain protein
FY534_RS00890	COG2814	Major facilitator Superfamily
FY534_RS00905	COG1802	Transcriptional regulator
FY534_RS00920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY534_RS00925	COG0405	Gamma-glutamyltransferase
FY534_RS00930	COG2059	Chromate
FY534_RS00935	COG2059	Chromate
FY534_RS00960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY534_RS00975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FY534_RS00990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY534_RS01065	COG1175	transmembrane transport
FY534_RS01070	COG0395	ABC-type sugar transport system, permease component
FY534_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
FY534_RS01140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FY534_RS01150	COG1214	PFAM Peptidase M22, glycoprotease
FY534_RS01155	COG0456	acetyltransferase
FY534_RS01160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY534_RS01195	COG0697	spore germination
FY534_RS01200	COG0488	(ABC) transporter
FY534_RS01205	COG0671	phosphoesterase, PA-phosphatase related
FY534_RS01215	COG0746	molybdenum cofactor guanylyltransferase activity
FY534_RS01220	COG1546	Belongs to the CinA family
FY534_RS01220	COG1058	Belongs to the CinA family
FY534_RS01235	COG0459	protein refolding
FY534_RS01240	COG0714	Associated with various cellular activities
FY534_RS01250	COG1305	Transglutaminase-like
FY534_RS01255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY534_RS01255	COG0519	Catalyzes the synthesis of GMP from XMP
FY534_RS01265	COG0708	Exodeoxyribonuclease III
FY534_RS01275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY534_RS01280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY534_RS01290	COG0047	phosphoribosylformylglycinamidine synthase activity
FY534_RS01295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY534_RS01300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY534_RS01305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY534_RS01310	COG0138	bifunctional purine biosynthesis protein purh
FY534_RS01315	COG0151	Belongs to the GarS family
FY534_RS01320	COG1533	DNA photolyase activity
FY534_RS01325	COG0745	RESPONSE REGULATOR receiver
FY534_RS01330	COG2124	cytochrome p450
FY534_RS01350	COG1309	transcriptional regulator
FY534_RS01360	COG3880	PFAM UvrB UvrC protein
FY534_RS01365	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FY534_RS01370	COG0542	response to heat
FY534_RS01375	COG3344	reverse transcriptase
FY534_RS01380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FY534_RS01385	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FY534_RS01390	COG1183	phosphatidylcholine synthase activity
FY534_RS01395	COG4956	integral membrane protein (PIN domain superfamily)
FY534_RS01400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY534_RS01410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY534_RS01415	COG0215	cysteine-tRNA ligase activity
FY534_RS01420	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FY534_RS01425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY534_RS01440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY534_RS01450	COG0250	Participates in transcription elongation, termination and antitermination
FY534_RS01465	COG0081	regulation of translation
FY534_RS01470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY534_RS01475	COG0222	ribosome binding
FY534_RS01480	COG2813	Specifically methylates the guanine in position
FY534_RS01485	COG0085	RNA polymerase activity
FY534_RS01490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY534_RS01495	COG2801	Transposase and inactivated derivatives
FY534_RS01500	COG1358	cellular component organization or biogenesis
FY534_RS01505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY534_RS01510	COG0049	tRNA binding
FY534_RS01515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY534_RS01520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY534_RS01525	COG0051	transcription antitermination factor activity, RNA binding
FY534_RS01530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY534_RS01545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY534_RS01550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY534_RS01555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY534_RS01560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY534_RS01565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY534_RS01570	COG0255	Belongs to the universal ribosomal protein uL29 family
FY534_RS01580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY534_RS01595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY534_RS01600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY534_RS01605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY534_RS01610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY534_RS01615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY534_RS01620	COG1841	ribosomal large subunit assembly
FY534_RS01625	COG0200	Binds to the 23S rRNA
FY534_RS01630	COG0201	protein transport
FY534_RS01635	COG0563	adenylate kinase activity
FY534_RS01645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY534_RS01650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY534_RS01655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY534_RS01660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY534_RS01665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY534_RS01670	COG0202	RNA polymerase activity
FY534_RS01675	COG0203	ribosomal protein L17
FY534_RS01680	COG0101	tRNA pseudouridine synthase activity
FY534_RS01685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY534_RS01690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY534_RS01695	COG0860	N-Acetylmuramoyl-L-alanine amidase
FY534_RS01705	COG0489	protein tyrosine kinase activity
FY534_RS01735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FY534_RS01745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY534_RS01800	COG3586	endonuclease activity
FY534_RS01810	COG0515	serine threonine protein kinase
FY534_RS01810	COG2815	serine threonine protein kinase
FY534_RS01835	COG1073	alpha beta
FY534_RS01850	COG0456	acetyltransferase
FY534_RS01850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FY534_RS01880	COG1657	PFAM Prenyltransferase squalene oxidase
FY534_RS01895	COG1279	arginine transmembrane transporter activity
FY534_RS01910	COG1653	transport
FY534_RS01915	COG1175	transmembrane transport
FY534_RS01920	COG3833	ABC-type maltose transport systems, permease component
FY534_RS01940	COG1607	acyl-coa hydrolase
FY534_RS01950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY534_RS01970	COG4585	Histidine kinase
FY534_RS01995	COG2318	DinB family
FY534_RS02000	COG1968	undecaprenyl-diphosphatase activity
FY534_RS02005	COG2223	nitrite transmembrane transporter activity
FY534_RS02010	COG0436	Aminotransferase
FY534_RS02020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY534_RS02025	COG1113	amino acid transport
FY534_RS02030	COG0175	sulfate reduction
FY534_RS02035	COG2046	Belongs to the sulfate adenylyltransferase family
FY534_RS02040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY534_RS02060	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY534_RS02075	COG1122	ATPase activity
FY534_RS02080	COG1268	BioY protein
FY534_RS02085	COG1802	Transcriptional regulator
FY534_RS02110	COG0174	glutamine synthetase
FY534_RS02125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY534_RS02130	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY534_RS02135	COG0412	Dienelactone hydrolase
FY534_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY534_RS02145	COG2814	Major facilitator Superfamily
FY534_RS02150	COG1278	Cold shock
FY534_RS02165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY534_RS02190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FY534_RS02190	COG2199	diguanylate cyclase activity
FY534_RS02200	COG0745	RESPONSE REGULATOR receiver
FY534_RS02205	COG5002	protein histidine kinase activity
FY534_RS02210	COG1307	EDD domain protein, DegV family
FY534_RS02215	COG1040	competence protein
FY534_RS02225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY534_RS02240	COG1191	sigma factor activity
FY534_RS02255	COG4786	Flagellar basal body rod
FY534_RS02255	COG1256	bacterial-type flagellum assembly
FY534_RS02280	COG0463	Glycosyl transferase, family 2
FY534_RS02280	COG0457	Tetratricopeptide repeat
FY534_RS02285	COG1216	Glycosyl transferase, family 2
FY534_RS02285	COG0438	transferase activity, transferring glycosyl groups
FY534_RS02290	COG0438	transferase activity, transferring glycosyl groups
FY534_RS02300	COG0463	Glycosyl transferase, family 2
FY534_RS02305	COG0457	Tetratricopeptide repeat
FY534_RS02305	COG0463	Glycosyl transferase, family 2
FY534_RS02310	COG0653	protein targeting
FY534_RS02345	COG2884	Cell division ATP-binding protein ftsE
FY534_RS02350	COG2177	Part of the ABC transporter FtsEX involved in
FY534_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS02365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY534_RS02375	COG0556	nucleotide-excision repair
FY534_RS02380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY534_RS02390	COG0018	arginyl-trna synthetase
FY534_RS02400	COG1660	Displays ATPase and GTPase activities
FY534_RS02405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FY534_RS02410	COG1481	regulation of sporulation
FY534_RS02420	COG2197	response regulator
FY534_RS02435	COG1131	(ABC) transporter
FY534_RS02445	COG1335	isochorismatase
FY534_RS02460	COG0670	Belongs to the BI1 family
FY534_RS02465	COG0495	leucyl-tRNA aminoacylation
FY534_RS02480	COG0813	purine-nucleoside phosphorylase activity
FY534_RS02490	COG0628	permease
FY534_RS02505	COG0318	PFAM AMP-dependent synthetase and ligase
FY534_RS02515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FY534_RS02525	COG0697	spore germination
FY534_RS02560	COG0538	isocitrate dehydrogenase activity
FY534_RS02605	COG2766	serine protein kinase
FY534_RS02610	COG2718	Belongs to the UPF0229 family
FY534_RS02615	COG2719	SpoVR family
FY534_RS02645	COG0395	ABC-type sugar transport system, permease component
FY534_RS02650	COG1414	Transcriptional regulator
FY534_RS02655	COG1960	acyl-CoA dehydrogenase activity
FY534_RS02675	COG0668	transmembrane transport
FY534_RS02705	COG0004	ammonium transporteR
FY534_RS02720	COG2176	DNA-directed DNA polymerase activity
FY534_RS02730	COG1686	Belongs to the peptidase S11 family
FY534_RS02735	COG1132	(ABC) transporter
FY534_RS02740	COG1132	(ABC) transporter
FY534_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS02815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY534_RS02825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY534_RS02830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY534_RS02835	COG0154	amidase activity
FY534_RS02840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY534_RS02845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY534_RS02850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY534_RS02855	COG0798	PFAM Bile acid sodium symporter
FY534_RS02860	COG0640	Transcriptional regulator
FY534_RS02865	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS02875	COG0681	Belongs to the peptidase S26 family
FY534_RS02915	COG0789	Transcriptional regulator
FY534_RS02920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS02940	COG1082	Xylose isomerase domain protein TIM barrel
FY534_RS02950	COG0673	inositol 2-dehydrogenase activity
FY534_RS02955	COG0673	inositol 2-dehydrogenase activity
FY534_RS02960	COG1605	Chorismate mutase
FY534_RS02960	COG0077	Prephenate dehydratase
FY534_RS02965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FY534_RS02970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY534_RS02990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FY534_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
FY534_RS03010	COG1960	acyl-CoA dehydrogenase activity
FY534_RS03015	COG1024	Enoyl-CoA hydratase
FY534_RS03035	COG2197	response regulator
FY534_RS03055	COG1609	Transcriptional regulator
FY534_RS03060	COG0747	negative chemotaxis
FY534_RS03080	COG4608	Belongs to the ABC transporter superfamily
FY534_RS03090	COG2723	6-phospho-beta-galactosidase activity
FY534_RS03095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY534_RS03100	COG2124	cytochrome p450
FY534_RS03140	COG0745	RESPONSE REGULATOR receiver
FY534_RS03145	COG2205	protein histidine kinase activity
FY534_RS03155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY534_RS03160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY534_RS03170	COG2205	protein histidine kinase activity
FY534_RS03175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY534_RS03180	COG1595	DNA-templated transcription, initiation
FY534_RS03195	COG0671	phosphoesterase, PA-phosphatase related
FY534_RS03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY534_RS03215	COG3844	kynureninase activity
FY534_RS03240	COG0277	FAD linked oxidase domain protein
FY534_RS03275	COG1937	Protein conserved in bacteria
FY534_RS03280	COG2217	Heavy metal translocating P-type atpase
FY534_RS03290	COG0351	phosphomethylpyrimidine kinase
FY534_RS03295	COG0352	thiamine-phosphate diphosphorylase activity
FY534_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS03315	COG2095	MarC family integral membrane protein
FY534_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS03325	COG3848	Pyruvate phosphate dikinase
FY534_RS03325	COG0574	Belongs to the PEP-utilizing enzyme family
FY534_RS03330	COG3848	Pyruvate phosphate dikinase
FY534_RS03330	COG0574	Belongs to the PEP-utilizing enzyme family
FY534_RS03335	COG2814	Major facilitator Superfamily
FY534_RS03340	COG1175	transmembrane transport
FY534_RS03345	COG0395	ABC-type sugar transport system, permease component
FY534_RS03360	COG1216	Glycosyl transferase, family 2
FY534_RS03365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY534_RS03375	COG2124	cytochrome p450
FY534_RS03385	COG1562	ergosterol biosynthetic process
FY534_RS03390	COG0142	geranyltranstransferase activity
FY534_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS03410	COG0640	Transcriptional regulator
FY534_RS03415	COG0500	methyltransferase
FY534_RS03455	COG4974	Belongs to the 'phage' integrase family
FY534_RS03460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FY534_RS03470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FY534_RS03495	COG1331	Highly conserved protein containing a thioredoxin domain
FY534_RS03500	COG1331	Highly conserved protein containing a thioredoxin domain
FY534_RS03505	COG3858	chitin binding
FY534_RS03505	COG1388	LysM domain
FY534_RS03510	COG0346	lactoylglutathione lyase activity
FY534_RS03515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY534_RS03525	COG5577	PFAM Coat F domain
FY534_RS03530	COG0019	diaminopimelate decarboxylase activity
FY534_RS03565	COG1164	Oligoendopeptidase f
FY534_RS03570	COG3852	Histidine kinase
FY534_RS03580	COG0697	spore germination
FY534_RS03585	COG0126	phosphoglycerate kinase activity
FY534_RS03595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY534_RS03600	COG0148	phosphopyruvate hydratase activity
FY534_RS03605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY534_RS03610	COG0557	exoribonuclease II activity
FY534_RS03615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY534_RS03625	COG0501	Belongs to the peptidase M48B family
FY534_RS03640	COG3239	Fatty acid desaturase
FY534_RS03655	COG1648	precorrin-2 dehydrogenase activity
FY534_RS03655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY534_RS03675	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY534_RS03705	COG1492	cobalamin metabolic process
FY534_RS03710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY534_RS03720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS03725	COG2210	Belongs to the sulfur carrier protein TusA family
FY534_RS03730	COG0425	Belongs to the sulfur carrier protein TusA family
FY534_RS03730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS03735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS03735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS03740	COG3344	reverse transcriptase
FY534_RS03745	COG0730	response to heat
FY534_RS03750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS03755	COG1937	Protein conserved in bacteria
FY534_RS03765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY534_RS03775	COG1414	Transcriptional regulator
FY534_RS03790	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS03805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY534_RS03810	COG3842	ATPase activity
FY534_RS03830	COG1234	tRNA 3'-trailer cleavage
FY534_RS03840	COG0300	oxidoreductase activity
FY534_RS03850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY534_RS03870	COG1216	Glycosyl transferase, family 2
FY534_RS03875	COG0667	Aldo Keto reductase
FY534_RS03880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY534_RS03885	COG1733	regulation of RNA biosynthetic process
FY534_RS03905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FY534_RS03915	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY534_RS03920	COG2070	2-Nitropropane dioxygenase
FY534_RS03925	COG0010	Belongs to the arginase family
FY534_RS03930	COG1228	amidohydrolase
FY534_RS03945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY534_RS03950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FY534_RS03955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY534_RS03960	COG0318	PFAM AMP-dependent synthetase and ligase
FY534_RS03965	COG3103	Sh3 type 3 domain protein
FY534_RS03965	COG1388	LysM domain
FY534_RS03965	COG0791	NLP P60 protein
FY534_RS03970	COG0697	spore germination
FY534_RS03975	COG2224	Isocitrate lyase
FY534_RS03995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY534_RS04040	COG2827	Endonuclease containing a URI domain
FY534_RS04055	COG2814	Major facilitator Superfamily
FY534_RS04065	COG0154	amidase activity
FY534_RS04070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY534_RS04075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY534_RS04095	COG3973	AAA domain
FY534_RS04105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY534_RS04110	COG1584	GPR1 FUN34 yaaH family protein
FY534_RS04150	COG0579	oxidoreductase
FY534_RS04155	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY534_RS04190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY534_RS04215	COG1482	cell wall glycoprotein biosynthetic process
FY534_RS04225	COG3344	reverse transcriptase
FY534_RS04230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY534_RS04235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY534_RS04240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY534_RS04245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY534_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY534_RS04275	COG1609	Transcriptional regulator
FY534_RS04285	COG0463	Glycosyl transferase, family 2
FY534_RS04300	COG1215	transferase activity, transferring glycosyl groups
FY534_RS04310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FY534_RS04315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY534_RS04330	COG3546	catalase activity
FY534_RS04335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FY534_RS04360	COG0567	Dehydrogenase, E1 component
FY534_RS04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY534_RS04370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS04380	COG0584	glycerophosphoryl diester phosphodiesterase
FY534_RS04395	COG2508	Transcriptional regulator
FY534_RS04400	COG3842	ATPase activity
FY534_RS04405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY534_RS04410	COG0205	6-phosphofructokinase activity
FY534_RS04420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY534_RS04425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY534_RS04430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY534_RS04435	COG0072	phenylalanine-tRNA ligase activity
FY534_RS04435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY534_RS04445	COG1286	toxin biosynthetic process
FY534_RS04455	COG1193	negative regulation of DNA recombination
FY534_RS04460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY534_RS04465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY534_RS04475	COG0840	transmembrane signaling receptor activity
FY534_RS04490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY534_RS04490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FY534_RS04500	COG0217	transcriptional regulatory protein
FY534_RS04510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY534_RS04515	COG0632	four-way junction helicase activity
FY534_RS04520	COG2255	four-way junction helicase activity
FY534_RS04525	COG1191	sigma factor activity
FY534_RS04535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY534_RS04540	COG0343	queuine tRNA-ribosyltransferase activity
FY534_RS04560	COG2323	membrane
FY534_RS04565	COG2244	polysaccharide biosynthetic process
FY534_RS04575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FY534_RS04580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FY534_RS04585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY534_RS04590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY534_RS04595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY534_RS04600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FY534_RS04620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY534_RS04635	COG0569	domain protein
FY534_RS04635	COG0475	glutathione-regulated potassium exporter activity
FY534_RS04645	COG0456	acetyltransferase
FY534_RS04650	COG0714	Associated with various cellular activities
FY534_RS04675	COG0791	NLP P60 protein
FY534_RS04675	COG1388	LysM domain
FY534_RS04680	COG3344	reverse transcriptase
FY534_RS04685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FY534_RS04690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY534_RS04695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY534_RS04705	COG1929	Belongs to the glycerate kinase type-1 family
FY534_RS04710	COG3253	May function as heme-dependent peroxidase
FY534_RS04715	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY534_RS04720	COG1321	iron dependent repressor
FY534_RS04735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY534_RS04740	COG0477	Major facilitator Superfamily
FY534_RS04750	COG1074	ATP-dependent DNA helicase activity
FY534_RS04755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY534_RS04765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY534_RS04770	COG0303	'Molybdopterin
FY534_RS04775	COG0667	Aldo Keto reductase
FY534_RS04780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FY534_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS04790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY534_RS04805	COG0183	Belongs to the thiolase family
FY534_RS04810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FY534_RS04810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY534_RS04820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FY534_RS04830	COG2814	Major facilitator Superfamily
FY534_RS04840	COG1131	(ABC) transporter
FY534_RS04875	COG0124	histidyl-tRNA synthetase
FY534_RS04880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY534_RS04900	COG1959	2 iron, 2 sulfur cluster binding
FY534_RS04905	COG1104	cysteine desulfurase activity
FY534_RS04920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY534_RS04925	COG0628	permease
FY534_RS04930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY534_RS04935	COG4472	Bacterial protein of unknown function (DUF965)
FY534_RS04940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY534_RS04945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY534_RS04955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FY534_RS04960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FY534_RS04965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY534_RS04970	COG1534	Rna-binding protein
FY534_RS04975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY534_RS04980	COG1713	HD superfamily hydrolase involved in NAD metabolism
FY534_RS04985	COG0799	negative regulation of ribosome biogenesis
FY534_RS04995	COG1555	photosystem II stabilization
FY534_RS04995	COG1596	polysaccharide export
FY534_RS05005	COG1252	NADH dehydrogenase
FY534_RS05010	COG1466	dna polymerase III delta subunit
FY534_RS05020	COG0268	Binds directly to 16S ribosomal RNA
FY534_RS05025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FY534_RS05030	COG0741	lytic transglycosylase activity
FY534_RS05045	COG0481	GTPase activity
FY534_RS05050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY534_RS05055	COG1420	regulation of RNA biosynthetic process
FY534_RS05065	COG0443	Heat shock 70 kDa protein
FY534_RS05070	COG0484	heat shock protein binding
FY534_RS05075	COG2264	protein methyltransferase activity
FY534_RS05080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FY534_RS05085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY534_RS05095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY534_RS05100	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY534_RS05105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY534_RS05110	COG1610	YqeY-like protein
FY534_RS05125	COG1702	phosphate starvation-inducible protein PhoH
FY534_RS05130	COG1480	7TM receptor with intracellular HD hydrolase
FY534_RS05135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY534_RS05140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY534_RS05145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY534_RS05155	COG1381	Involved in DNA repair and RecF pathway recombination
FY534_RS05160	COG0517	IMP dehydrogenase activity
FY534_RS05165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY534_RS05170	COG0358	DNA primase activity
FY534_RS05175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY534_RS05180	COG1960	acyl-CoA dehydrogenase activity
FY534_RS05195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FY534_RS05205	COG0454	-acetyltransferase
FY534_RS05210	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FY534_RS05225	COG3189	MarR family transcriptional regulator
FY534_RS05245	COG2346	COG2346, Truncated hemoglobins
FY534_RS05255	COG0791	NLP P60 protein
FY534_RS05255	COG3883	PFAM NLP P60 protein
FY534_RS05285	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FY534_RS05290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY534_RS05295	COG0697	spore germination
FY534_RS05305	COG0071	Belongs to the small heat shock protein (HSP20) family
FY534_RS05310	COG1648	precorrin-2 dehydrogenase activity
FY534_RS05310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY534_RS05315	COG0602	queuosine metabolic process
FY534_RS05320	COG0720	synthase
FY534_RS05325	COG2770	Histidine kinase
FY534_RS05325	COG3437	response regulator, receiver
FY534_RS05330	COG1733	regulation of RNA biosynthetic process
FY534_RS05335	COG2096	Adenosyltransferase
FY534_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS05360	COG1575	Belongs to the MenA family. Type 1 subfamily
FY534_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
FY534_RS05380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FY534_RS05390	COG0025	NhaP-type Na H and K H
FY534_RS05395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY534_RS05410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY534_RS05420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY534_RS05425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY534_RS05430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FY534_RS05440	COG0704	Plays a role in the regulation of phosphate uptake
FY534_RS05480	COG2801	Transposase and inactivated derivatives
FY534_RS05485	COG1509	lysine 2,3-aminomutase activity
FY534_RS05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY534_RS05505	COG2271	Major facilitator Superfamily
FY534_RS05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS05590	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY534_RS05595	COG0740	serine-type endopeptidase activity
FY534_RS05600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY534_RS05605	COG0470	DNA polymerase III
FY534_RS05605	COG1067	ATP-dependent peptidase activity
FY534_RS05615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY534_RS05625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY534_RS05630	COG0181	hydroxymethylbilane synthase activity
FY534_RS05640	COG0113	porphobilinogen synthase activity
FY534_RS05645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FY534_RS05665	COG0525	valine-tRNA ligase activity
FY534_RS05670	COG0285	dihydrofolate synthase activity
FY534_RS05675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY534_RS05695	COG3584	3D domain protein
FY534_RS05695	COG1388	LysM domain
FY534_RS05705	COG2003	Belongs to the UPF0758 family
FY534_RS05710	COG1077	Cell shape determining protein MreB Mrl
FY534_RS05725	COG0850	regulation of cytokinetic process
FY534_RS05730	COG2894	cell division
FY534_RS05755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY534_RS05785	COG2165	general secretion pathway protein
FY534_RS05805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY534_RS05810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY534_RS05820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FY534_RS05825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY534_RS05830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY534_RS05835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY534_RS05845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY534_RS05850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY534_RS05855	COG3854	ATPases associated with a variety of cellular activities
FY534_RS05895	COG0511	ligase activity, forming carbon-carbon bonds
FY534_RS05905	COG1302	Protein conserved in bacteria
FY534_RS05920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY534_RS05925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY534_RS05930	COG0492	ferredoxin-NADP+ reductase activity
FY534_RS05935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY534_RS05940	COG1570	exodeoxyribonuclease VII activity
FY534_RS05945	COG1722	exodeoxyribonuclease VII activity
FY534_RS05960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY534_RS05965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY534_RS05975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY534_RS05980	COG0497	DNA recombination
FY534_RS05985	COG0750	zinc metalloprotease
FY534_RS05990	COG0745	RESPONSE REGULATOR receiver
FY534_RS06000	COG2318	DinB family
FY534_RS06010	COG1388	LysM domain
FY534_RS06010	COG3584	3D domain protein
FY534_RS06020	COG1388	LysM domain
FY534_RS06020	COG3942	CHAP domain
FY534_RS06030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FY534_RS06035	COG0701	Predicted permease
FY534_RS06040	COG3858	chitin binding
FY534_RS06045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS06050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FY534_RS06065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FY534_RS06070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY534_RS06075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY534_RS06080	COG0022	dehydrogenase e1 component
FY534_RS06085	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY534_RS06090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY534_RS06095	COG0321	lipoyl(octanoyl) transferase activity
FY534_RS06100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY534_RS06100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY534_RS06105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY534_RS06110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY534_RS06120	COG2195	Cleaves the N-terminal amino acid of tripeptides
FY534_RS06130	COG1300	Membrane
FY534_RS06140	COG4974	Belongs to the 'phage' integrase family
FY534_RS06145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY534_RS06155	COG1686	Belongs to the peptidase S11 family
FY534_RS06170	COG2172	sigma factor antagonist activity
FY534_RS06175	COG1191	sigma factor activity
FY534_RS06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY534_RS06205	COG0805	protein transport
FY534_RS06210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY534_RS06220	COG1595	DNA-templated transcription, initiation
FY534_RS06230	COG1994	Peptidase M50
FY534_RS06235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY534_RS06240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY534_RS06250	COG3874	Sporulation protein YtfJ
FY534_RS06255	COG2715	membrane protein required for spore maturation
FY534_RS06260	COG0700	Nucleoside recognition
FY534_RS06265	COG1187	pseudouridine synthase activity
FY534_RS06270	COG0745	RESPONSE REGULATOR receiver
FY534_RS06275	COG5002	protein histidine kinase activity
FY534_RS06285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY534_RS06310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS06315	COG2226	methyltransferase
FY534_RS06325	COG0210	DNA helicase
FY534_RS06350	COG1609	Transcriptional regulator
FY534_RS06355	COG4862	establishment of competence for transformation
FY534_RS06360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FY534_RS06380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY534_RS06405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY534_RS06410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY534_RS06415	COG0509	glycine decarboxylation via glycine cleavage system
FY534_RS06420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FY534_RS06440	COG2226	methyltransferase
FY534_RS06450	COG0105	UTP biosynthetic process
FY534_RS06460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY534_RS06475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY534_RS06480	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY534_RS06510	COG2814	Major facilitator Superfamily
FY534_RS06515	COG0730	response to heat
FY534_RS06525	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS06535	COG2271	Major facilitator Superfamily
FY534_RS06555	COG1271	oxidase subunit
FY534_RS06560	COG2197	response regulator
FY534_RS06565	COG4585	Histidine kinase
FY534_RS06585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS06590	COG0492	ferredoxin-NADP+ reductase activity
FY534_RS06595	COG0667	Aldo Keto reductase
FY534_RS06605	COG0564	pseudouridine synthase activity
FY534_RS06610	COG1363	Peptidase, m42
FY534_RS06615	COG1363	Peptidase, m42
FY534_RS06620	COG1363	Peptidase, m42
FY534_RS06625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY534_RS06630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY534_RS06640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY534_RS06645	COG0134	indole-3-glycerol-phosphate synthase activity
FY534_RS06650	COG0135	phosphoribosylanthranilate isomerase activity
FY534_RS06655	COG0133	tryptophan synthase activity
FY534_RS06665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FY534_RS06670	COG0287	Prephenate dehydrogenase
FY534_RS06675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY534_RS06690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FY534_RS06695	COG3949	Membrane
FY534_RS06700	COG0473	3-isopropylmalate dehydrogenase activity
FY534_RS06705	COG1968	undecaprenyl-diphosphatase activity
FY534_RS06710	COG3314	Sporulation integral membrane protein YlbJ
FY534_RS06715	COG1694	Mazg nucleotide pyrophosphohydrolase
FY534_RS06725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY534_RS06730	COG0438	transferase activity, transferring glycosyl groups
FY534_RS06735	COG0617	tRNA 3'-terminal CCA addition
FY534_RS06750	COG1199	ATP-dependent helicase activity
FY534_RS06750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY534_RS06755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FY534_RS06760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FY534_RS06765	COG0402	S-adenosylhomocysteine deaminase activity
FY534_RS06770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY534_RS06790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY534_RS06795	COG3344	reverse transcriptase
FY534_RS06800	COG0017	Asparaginyl-tRNA synthetase
FY534_RS06805	COG3935	DnaD domain protein
FY534_RS06810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY534_RS06815	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY534_RS06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FY534_RS06825	COG1566	PFAM secretion protein HlyD family protein
FY534_RS06830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY534_RS06835	COG1271	oxidase subunit
FY534_RS06840	COG1294	oxidase, subunit
FY534_RS06845	COG0425	Belongs to the sulfur carrier protein TusA family
FY534_RS06845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY534_RS06855	COG1119	ATPase activity
FY534_RS06860	COG1506	peptidase
FY534_RS06865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS06870	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FY534_RS06875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FY534_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS06885	COG0646	methionine synthase
FY534_RS06885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY534_RS06890	COG0646	methionine synthase
FY534_RS06890	COG1410	methionine synthase
FY534_RS06905	COG0423	glycine-tRNA ligase activity
FY534_RS06915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY534_RS06920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY534_RS06925	COG1846	Transcriptional regulator
FY534_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS06945	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY534_RS06950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY534_RS06960	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY534_RS06960	COG1902	pentaerythritol trinitrate reductase activity
FY534_RS06970	COG1960	acyl-CoA dehydrogenase activity
FY534_RS06975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FY534_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS06990	COG2197	response regulator
FY534_RS06995	COG0667	Aldo Keto reductase
FY534_RS07005	COG2188	Transcriptional regulator
FY534_RS07010	COG2814	Major facilitator Superfamily
FY534_RS07020	COG1054	Belongs to the UPF0176 family
FY534_RS07030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FY534_RS07035	COG1053	succinate dehydrogenase
FY534_RS07040	COG2009	succinate dehydrogenase
FY534_RS07045	COG0322	excinuclease ABC activity
FY534_RS07070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY534_RS07080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY534_RS07085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY534_RS07095	COG0387	Pfam Sodium calcium exchanger
FY534_RS07135	COG0463	Glycosyl transferase, family 2
FY534_RS07145	COG1846	Transcriptional regulator
FY534_RS07195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY534_RS07200	COG0647	UMP catabolic process
FY534_RS07210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS07230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY534_RS07255	COG3850	Histidine kinase
FY534_RS07255	COG5002	protein histidine kinase activity
FY534_RS07260	COG3850	Histidine kinase
FY534_RS07260	COG5002	protein histidine kinase activity
FY534_RS07265	COG0745	RESPONSE REGULATOR receiver
FY534_RS07320	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY534_RS07340	COG5001	Diguanylate cyclase
FY534_RS07340	COG3706	GGDEF domain
FY534_RS07340	COG4251	negative regulation of phosphorylation
FY534_RS07340	COG2203	Gaf domain
FY534_RS07390	COG0697	spore germination
FY534_RS07405	COG2226	methyltransferase
FY534_RS07410	COG2002	toxin-antitoxin pair type II binding
FY534_RS07415	COG2199	diguanylate cyclase activity
FY534_RS07415	COG2200	EAL domain
FY534_RS07420	COG2176	DNA-directed DNA polymerase activity
FY534_RS07555	COG1487	ribonuclease activity
FY534_RS07610	COG3547	Transposase (IS116 IS110 IS902 family)
FY534_RS07640	COG1131	(ABC) transporter
FY534_RS07680	COG0697	spore germination
FY534_RS07765	COG0789	Transcriptional regulator
FY534_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS07785	COG1388	LysM domain
FY534_RS07805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FY534_RS07845	COG2801	Transposase and inactivated derivatives
FY534_RS07860	COG0464	growth
FY534_RS07895	COG5002	protein histidine kinase activity
FY534_RS07900	COG2197	response regulator
FY534_RS07905	COG5001	Diguanylate cyclase
FY534_RS07905	COG3300	MHYT domain
FY534_RS07920	COG1215	transferase activity, transferring glycosyl groups
FY534_RS07980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY534_RS08000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY534_RS08000	COG1199	ATP-dependent helicase activity
FY534_RS08015	COG0582	viral genome integration into host DNA
FY534_RS08020	COG2002	toxin-antitoxin pair type II binding
FY534_RS08155	COG0582	viral genome integration into host DNA
FY534_RS08170	COG3385	transposase activity
FY534_RS08185	COG0174	glutamine synthetase
FY534_RS08190	COG0789	Transcriptional regulator
FY534_RS08195	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FY534_RS08210	COG0464	growth
FY534_RS08270	COG1923	regulation of RNA biosynthetic process
FY534_RS08275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY534_RS08285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY534_RS08290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY534_RS08300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY534_RS08305	COG0384	phenazine biosynthesis protein PhzF
FY534_RS08310	COG0189	ligase activity
FY534_RS08340	COG2359	stage V sporulation protein S
FY534_RS08345	COG1692	metallophosphoesterase
FY534_RS08350	COG1418	mRNA catabolic process
FY534_RS08360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY534_RS08365	COG0513	Belongs to the DEAD box helicase family
FY534_RS08370	COG1058	Belongs to the CinA family
FY534_RS08370	COG1546	Belongs to the CinA family
FY534_RS08375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY534_RS08385	COG1426	Protein conserved in bacteria
FY534_RS08410	COG1674	ftsk spoiiie
FY534_RS08420	COG0740	serine-type endopeptidase activity
FY534_RS08425	COG1914	H( )-stimulated, divalent metal cation uptake system
FY534_RS08435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FY534_RS08450	COG0527	aspartate kinase activity
FY534_RS08455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY534_RS08460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY534_RS08465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY534_RS08475	COG0612	Peptidase, M16
FY534_RS08480	COG0726	polysaccharide deacetylase
FY534_RS08485	COG1185	polyribonucleotide nucleotidyltransferase activity
FY534_RS08490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY534_RS08495	COG0196	riboflavin kinase activity
FY534_RS08500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY534_RS08510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY534_RS08530	COG0195	Participates in both transcription termination and antitermination
FY534_RS08535	COG0779	Required for maturation of 30S ribosomal subunits
FY534_RS08540	COG1217	gtp-binding protein TYPA
FY534_RS08545	COG0077	Prephenate dehydratase
FY534_RS08545	COG1605	Chorismate mutase
FY534_RS08550	COG2176	DNA-directed DNA polymerase activity
FY534_RS08555	COG0750	zinc metalloprotease
FY534_RS08560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY534_RS08565	COG4589	Belongs to the CDS family
FY534_RS08570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY534_RS08575	COG0233	cytoplasmic translational termination
FY534_RS08580	COG0528	UMP kinase activity
FY534_RS08585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY534_RS08590	COG0052	Belongs to the universal ribosomal protein uS2 family
FY534_RS08600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY534_RS08615	COG0643	Histidine kinase
FY534_RS08615	COG2198	Histidine kinase
FY534_RS08620	COG0455	bacterial-type flagellum organization
FY534_RS08625	COG1419	protein localization to endoplasmic reticulum
FY534_RS08630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY534_RS08635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY534_RS08645	COG1987	bacterial-type flagellum assembly
FY534_RS08650	COG1338	Plays a role in the flagellum-specific transport system
FY534_RS08660	COG2201	protein-glutamate methylesterase activity
FY534_RS08665	COG1776	CheC inhibitor of MCP methylation
FY534_RS08665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY534_RS08670	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY534_RS08685	COG4786	Flagellar basal body rod
FY534_RS08695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY534_RS08715	COG1157	protein secretion by the type III secretion system
FY534_RS08725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY534_RS08730	COG1766	The M ring may be actively involved in energy transduction
FY534_RS08735	COG1677	Flagellar hook-basal body complex protein FliE
FY534_RS08745	COG1815	bacterial-type flagellum-dependent cell motility
FY534_RS08750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY534_RS08755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY534_RS08760	COG4974	Belongs to the 'phage' integrase family
FY534_RS08765	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY534_RS08770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY534_RS08775	COG0758	DNA mediated transformation
FY534_RS08780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY534_RS08785	COG0045	succinate-CoA ligase (ADP-forming) activity
FY534_RS08800	COG0792	nuclease activity
FY534_RS08815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY534_RS08820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FY534_RS08825	COG0335	large ribosomal subunit rRNA binding
FY534_RS08850	COG1607	acyl-coa hydrolase
FY534_RS08855	COG0739	heme binding
FY534_RS08860	COG0824	Thioesterase
FY534_RS08865	COG0564	pseudouridine synthase activity
FY534_RS08870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS08890	COG0336	Belongs to the RNA methyltransferase TrmD family
FY534_RS08895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY534_RS08905	COG1837	Belongs to the UPF0109 family
FY534_RS08910	COG0228	four-way junction DNA binding
FY534_RS08915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY534_RS08925	COG0552	protein localization to endoplasmic reticulum
FY534_RS08930	COG1196	nuclear chromosome segregation
FY534_RS08935	COG0571	ribonuclease III activity
FY534_RS08940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY534_RS08945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY534_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS08955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY534_RS08960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY534_RS08965	COG0416	fatty acid biosynthetic process
FY534_RS08970	COG1349	DNA-binding transcription factor activity
FY534_RS08975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY534_RS08985	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY534_RS08990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY534_RS08995	COG0742	ribosomal rna small subunit methyltransferase
FY534_RS09005	COG0154	amidase activity
FY534_RS09010	COG0438	transferase activity, transferring glycosyl groups
FY534_RS09020	COG0688	phosphatidylethanolamine metabolic process
FY534_RS09030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY534_RS09035	COG1461	Dihydroxyacetone kinase
FY534_RS09040	COG1302	Protein conserved in bacteria
FY534_RS09045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY534_RS09055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FY534_RS09060	COG1162	GTPase activity
FY534_RS09065	COG0515	serine threonine protein kinase
FY534_RS09065	COG2815	serine threonine protein kinase
FY534_RS09070	COG0631	protein serine/threonine phosphatase activity
FY534_RS09075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY534_RS09080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY534_RS09080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY534_RS09085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY534_RS09090	COG0242	peptide deformylase activity
FY534_RS09095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FY534_RS09100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY534_RS09105	COG1758	RNA polymerase activity
FY534_RS09110	COG0194	GDP metabolic process
FY534_RS09120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FY534_RS09135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FY534_RS09160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY534_RS09165	COG0540	Belongs to the ATCase OTCase family
FY534_RS09175	COG3344	reverse transcriptase
FY534_RS09185	COG0564	pseudouridine synthase activity
FY534_RS09190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY534_RS09195	COG1809	phosphosulfolactate synthase activity
FY534_RS09205	COG3599	regulation of cell shape
FY534_RS09220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY534_RS09225	COG1496	oxidoreductase activity
FY534_RS09230	COG1873	PFAM PRC-barrel domain
FY534_RS09235	COG1191	sigma factor activity
FY534_RS09240	COG1191	sigma factor activity
FY534_RS09250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY534_RS09255	COG0849	cell division
FY534_RS09260	COG3856	small basic protein
FY534_RS09275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY534_RS09280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY534_RS09285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY534_RS09290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY534_RS09295	COG0772	Belongs to the SEDS family
FY534_RS09300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY534_RS09305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY534_RS09310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY534_RS09315	COG0768	penicillin binding
FY534_RS09325	COG0275	rRNA processing
FY534_RS09330	COG2001	Belongs to the MraZ family
FY534_RS09335	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FY534_RS09340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY534_RS09345	COG1024	Enoyl-CoA hydratase
FY534_RS09350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY534_RS09355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY534_RS09360	COG0439	Biotin carboxylase
FY534_RS09365	COG0300	oxidoreductase activity
FY534_RS09390	COG0301	tRNA thio-modification
FY534_RS09395	COG1104	cysteine desulfurase activity
FY534_RS09400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FY534_RS09410	COG0740	serine-type endopeptidase activity
FY534_RS09440	COG3679	Belongs to the UPF0342 family
FY534_RS09445	COG3906	Belongs to the UPF0473 family
FY534_RS09450	COG2271	Major facilitator Superfamily
FY534_RS09455	COG0753	catalase activity
FY534_RS09460	COG4948	Mandelate Racemase Muconate Lactonizing
FY534_RS09475	COG1216	Glycosyl transferase, family 2
FY534_RS09490	COG0438	transferase activity, transferring glycosyl groups
FY534_RS09505	COG4191	Histidine kinase
FY534_RS09510	COG2017	converts alpha-aldose to the beta-anomer
FY534_RS09515	COG2814	Major facilitator Superfamily
FY534_RS09520	COG1070	Carbohydrate kinase
FY534_RS09525	COG2115	Belongs to the xylose isomerase family
FY534_RS09530	COG1940	carbohydrate kinase activity
FY534_RS09540	COG2814	Major facilitator Superfamily
FY534_RS09545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY534_RS09560	COG1802	Transcriptional regulator
FY534_RS09565	COG1132	(ABC) transporter
FY534_RS09570	COG1609	Transcriptional regulator
FY534_RS09575	COG1070	Carbohydrate kinase
FY534_RS09580	COG2271	Major facilitator Superfamily
FY534_RS09600	COG2814	Major facilitator Superfamily
FY534_RS09610	COG4372	Transposase
FY534_RS09640	COG4974	Belongs to the 'phage' integrase family
FY534_RS09675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FY534_RS09680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY534_RS09685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY534_RS09695	COG3383	formate dehydrogenase (NAD+) activity
FY534_RS09705	COG0165	Argininosuccinate lyase
FY534_RS09710	COG0137	argininosuccinate synthase activity
FY534_RS09715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY534_RS09720	COG0070	glutamate synthase
FY534_RS09720	COG0069	glutamate synthase activity
FY534_RS09720	COG0067	glutamate synthase
FY534_RS09725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FY534_RS09730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY534_RS09740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY534_RS09755	COG1842	Phage shock protein A
FY534_RS09780	COG0512	Glutamine amidotransferase of anthranilate synthase
FY534_RS09835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FY534_RS09840	COG0352	thiamine-phosphate diphosphorylase activity
FY534_RS09845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY534_RS09850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY534_RS09850	COG2022	thiamine diphosphate biosynthetic process
FY534_RS09860	COG2022	thiamine diphosphate biosynthetic process
FY534_RS09880	COG1984	allophanate hydrolase subunit 2
FY534_RS09885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY534_RS09900	COG1414	Transcriptional regulator
FY534_RS09915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY534_RS09920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY534_RS09935	COG2176	DNA-directed DNA polymerase activity
FY534_RS09960	COG2860	membrane
FY534_RS09970	COG0531	amino acid
FY534_RS09975	COG2186	Transcriptional regulator
FY534_RS09985	COG1139	Iron-sulfur cluster binding protein
FY534_RS09990	COG1556	Lactate utilization protein
FY534_RS09995	COG1349	DNA-binding transcription factor activity
FY534_RS10000	COG4952	isomerase
FY534_RS10010	COG1070	Carbohydrate kinase
FY534_RS10015	COG3254	rhamnose metabolic process
FY534_RS10020	COG2814	Major facilitator Superfamily
FY534_RS10025	COG2814	Major facilitator Superfamily
FY534_RS10035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FY534_RS10040	COG1562	ergosterol biosynthetic process
FY534_RS10045	COG1562	ergosterol biosynthetic process
FY534_RS10050	COG1657	PFAM Prenyltransferase squalene oxidase
FY534_RS10055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY534_RS10070	COG1304	FMN binding
FY534_RS10080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY534_RS10095	COG3287	FIST C domain
FY534_RS10095	COG2200	EAL domain
FY534_RS10095	COG2199	diguanylate cyclase activity
FY534_RS10110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FY534_RS10110	COG0674	pyruvate-flavodoxin oxidoreductase activity
FY534_RS10115	COG1013	pyruvate-flavodoxin oxidoreductase activity
FY534_RS10130	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FY534_RS10135	COG1363	Peptidase, m42
FY534_RS10140	COG3377	Domain of unknown function (DUF1805)
FY534_RS10150	COG0586	Pfam SNARE associated Golgi protein
FY534_RS10155	COG1078	dGTPase activity
FY534_RS10160	COG0316	Belongs to the HesB IscA family
FY534_RS10165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY534_RS10170	COG1982	Orn Lys Arg decarboxylase major
FY534_RS10190	COG0436	Aminotransferase
FY534_RS10195	COG0772	Belongs to the SEDS family
FY534_RS10210	COG0772	Belongs to the SEDS family
FY534_RS10220	COG1956	GAF domain-containing protein
FY534_RS10235	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS10245	COG2050	protein possibly involved in aromatic compounds catabolism
FY534_RS10255	COG0318	PFAM AMP-dependent synthetase and ligase
FY534_RS10260	COG1285	pathogenesis
FY534_RS10265	COG0083	homoserine kinase activity
FY534_RS10270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FY534_RS10275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY534_RS10280	COG2814	Major facilitator Superfamily
FY534_RS10285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FY534_RS10290	COG0612	Peptidase, M16
FY534_RS10295	COG0612	Peptidase, M16
FY534_RS10305	COG0477	Major facilitator Superfamily
FY534_RS10310	COG1703	isobutyryl-CoA mutase activity
FY534_RS10310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY534_RS10310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY534_RS10315	COG1309	transcriptional regulator
FY534_RS10320	COG0768	penicillin binding
FY534_RS10335	COG5609	conserved protein (DUF2294)
FY534_RS10340	COG3002	Belongs to the UPF0753 family
FY534_RS10345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY534_RS10350	COG1960	acyl-CoA dehydrogenase activity
FY534_RS10355	COG0183	Belongs to the thiolase family
FY534_RS10360	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY534_RS10360	COG1024	Enoyl-CoA hydratase
FY534_RS10365	COG0537	adenosine 5'-monophosphoramidase activity
FY534_RS10380	COG0671	phosphoesterase, PA-phosphatase related
FY534_RS10395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FY534_RS10420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY534_RS10425	COG1024	Enoyl-CoA hydratase
FY534_RS10430	COG0531	amino acid
FY534_RS10440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY534_RS10445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY534_RS10450	COG0483	inositol monophosphate 1-phosphatase activity
FY534_RS10455	COG2124	cytochrome p450
FY534_RS10455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY534_RS10465	COG0114	fumarate hydratase activity
FY534_RS10480	COG4946	Tricorn protease homolog
FY534_RS10480	COG1506	peptidase
FY534_RS10480	COG0823	Involved in the tonB-independent uptake of proteins
FY534_RS10495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FY534_RS10500	COG2086	electron transfer activity
FY534_RS10505	COG1309	transcriptional regulator
FY534_RS10515	COG1959	2 iron, 2 sulfur cluster binding
FY534_RS10525	COG0719	Fe-S assembly protein
FY534_RS10530	COG0822	iron-sulfur transferase activity
FY534_RS10535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY534_RS10540	COG0719	Fe-S assembly protein
FY534_RS10545	COG0396	ATPase activity
FY534_RS10555	COG0686	Belongs to the AlaDH PNT family
FY534_RS10570	COG1595	DNA-templated transcription, initiation
FY534_RS10575	COG0167	dihydroorotate dehydrogenase activity
FY534_RS10590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FY534_RS10595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY534_RS10600	COG0302	gtp cyclohydrolase
FY534_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS10635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS10640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FY534_RS10645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY534_RS10650	COG1363	Peptidase, m42
FY534_RS10670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY534_RS10670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY534_RS10675	COG1215	transferase activity, transferring glycosyl groups
FY534_RS10685	COG0564	pseudouridine synthase activity
FY534_RS10690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY534_RS10695	COG2155	Conserved Protein
FY534_RS10705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY534_RS10705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FY534_RS10730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY534_RS10735	COG1376	ErfK ybiS ycfS ynhG family protein
FY534_RS10740	COG1960	acyl-CoA dehydrogenase activity
FY534_RS10745	COG2223	nitrite transmembrane transporter activity
FY534_RS10750	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FY534_RS10780	COG0482	sulfurtransferase activity
FY534_RS10785	COG0768	penicillin binding
FY534_RS10790	COG0583	DNA-binding transcription factor activity
FY534_RS10815	COG1122	ATPase activity
FY534_RS10820	COG4721	ABC-type cobalt transport system, permease component
FY534_RS10830	COG0697	spore germination
FY534_RS10835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY534_RS10835	COG0140	phosphoribosyl-ATP diphosphatase activity
FY534_RS10840	COG0107	imidazoleglycerol-phosphate synthase activity
FY534_RS10845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY534_RS10855	COG0131	Imidazoleglycerol-phosphate dehydratase
FY534_RS10865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY534_RS10870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY534_RS10880	COG0437	4 iron, 4 sulfur cluster binding
FY534_RS10890	COG0583	DNA-binding transcription factor activity
FY534_RS10895	COG0583	DNA-binding transcription factor activity
FY534_RS10915	COG1595	DNA-templated transcription, initiation
FY534_RS10920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY534_RS10925	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS10935	COG1024	Enoyl-CoA hydratase
FY534_RS10950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FY534_RS10955	COG2151	metal-sulfur cluster biosynthetic enzyme
FY534_RS10970	COG3396	Phenylacetate-CoA oxygenase
FY534_RS10975	COG1309	transcriptional regulator
FY534_RS10995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY534_RS11000	COG4166	transmembrane transport
FY534_RS11010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY534_RS11015	COG0531	amino acid
FY534_RS11020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY534_RS11025	COG1830	Aldolase
FY534_RS11035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY534_RS11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY534_RS11045	COG0116	Belongs to the methyltransferase superfamily
FY534_RS11050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY534_RS11065	COG1979	alcohol dehydrogenase
FY534_RS11075	COG2081	HI0933 family
FY534_RS11090	COG0424	maF-like protein
FY534_RS11095	COG0626	cystathionine gamma-synthase activity
FY534_RS11110	COG2363	Small membrane protein
FY534_RS11115	COG1215	transferase activity, transferring glycosyl groups
FY534_RS11145	COG2309	aminopeptidase activity
FY534_RS11150	COG5001	Diguanylate cyclase
FY534_RS11150	COG3300	MHYT domain
FY534_RS11180	COG0791	NLP P60 protein
FY534_RS11180	COG1388	LysM domain
FY534_RS11185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY534_RS11205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY534_RS11240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FY534_RS11245	COG0705	Rhomboid family
FY534_RS11260	COG0577	efflux transmembrane transporter activity
FY534_RS11285	COG0517	IMP dehydrogenase activity
FY534_RS11290	COG3239	Fatty acid desaturase
FY534_RS11300	COG0372	Belongs to the citrate synthase family
FY534_RS11310	COG1971	Probably functions as a manganese efflux pump
FY534_RS11320	COG0066	3-isopropylmalate dehydratase activity
FY534_RS11325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY534_RS11335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY534_RS11340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY534_RS11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY534_RS11380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY534_RS11390	COG0366	Alpha amylase catalytic
FY534_RS11405	COG1653	transport
FY534_RS11410	COG1609	Transcriptional regulator
FY534_RS11415	COG0531	amino acid
FY534_RS11420	COG0586	Pfam SNARE associated Golgi protein
FY534_RS11440	COG1388	LysM domain
FY534_RS11440	COG3858	chitin binding
FY534_RS11445	COG5002	protein histidine kinase activity
FY534_RS11465	COG4191	Histidine kinase
FY534_RS11495	COG0697	spore germination
FY534_RS11500	COG3858	chitin binding
FY534_RS11500	COG1388	LysM domain
FY534_RS11515	COG1132	(ABC) transporter
FY534_RS11520	COG1132	(ABC) transporter
FY534_RS11525	COG1827	regulation of RNA biosynthetic process
FY534_RS11530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FY534_RS11535	COG1757	Na H antiporter
FY534_RS11540	COG2155	Conserved Protein
FY534_RS11550	COG2233	PERMEase
FY534_RS11560	COG0601	transmembrane transport
FY534_RS11565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY534_RS11575	COG4608	Belongs to the ABC transporter superfamily
FY534_RS11580	COG0444	Belongs to the ABC transporter superfamily
FY534_RS11585	COG2814	Major facilitator Superfamily
FY534_RS11595	COG5002	protein histidine kinase activity
FY534_RS11600	COG0095	Lipoate-protein ligase
FY534_RS11605	COG5002	protein histidine kinase activity
FY534_RS11610	COG0745	RESPONSE REGULATOR receiver
FY534_RS11615	COG0583	DNA-binding transcription factor activity
FY534_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
FY534_RS11655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY534_RS11665	COG1072	(Pantothenic acid kinase))
FY534_RS11675	COG1612	heme a metabolic process
FY534_RS11680	COG0109	protoheme IX farnesyltransferase activity
FY534_RS11685	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY534_RS11690	COG1845	cytochrome c oxidase, subunit III
FY534_RS11695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY534_RS11710	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS11715	COG5001	Diguanylate cyclase
FY534_RS11715	COG5002	protein histidine kinase activity
FY534_RS11720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY534_RS11725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FY534_RS11730	COG1085	galactose-1-phosphate uridylyltransferase
FY534_RS11735	COG0475	glutathione-regulated potassium exporter activity
FY534_RS11735	COG0569	domain protein
FY534_RS11740	COG0475	glutathione-regulated potassium exporter activity
FY534_RS11740	COG0569	domain protein
FY534_RS11745	COG2205	protein histidine kinase activity
FY534_RS11750	COG0745	RESPONSE REGULATOR receiver
FY534_RS11755	COG4990	cell redox homeostasis
FY534_RS11760	COG0367	asparagine synthase
FY534_RS11770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY534_RS11780	COG0573	inorganic phosphate transmembrane transporter activity
FY534_RS11840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY534_RS11845	COG4989	oxidoreductase activity
FY534_RS11850	COG0667	Aldo Keto reductase
FY534_RS11870	COG1175	transmembrane transport
FY534_RS11880	COG0395	ABC-type sugar transport system, permease component
FY534_RS11885	COG1609	Transcriptional regulator
FY534_RS11890	COG1230	cation diffusion facilitator family transporter
FY534_RS11895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FY534_RS11920	COG0237	dephospho-CoA kinase activity
FY534_RS11925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY534_RS11935	COG0039	L-malate dehydrogenase activity
FY534_RS11940	COG0538	isocitrate dehydrogenase activity
FY534_RS11950	COG2084	Dehydrogenase
FY534_RS11960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY534_RS11970	COG0825	malonyl-CoA metabolic process
FY534_RS11975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY534_RS11985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FY534_RS11990	COG0587	DNA-directed DNA polymerase activity
FY534_RS11995	COG4109	DRTGG domain
FY534_RS12000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FY534_RS12005	COG4993	Dehydrogenase
FY534_RS12015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY534_RS12020	COG0735	belongs to the Fur family
FY534_RS12025	COG0450	alkyl hydroperoxide reductase
FY534_RS12030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY534_RS12040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FY534_RS12045	COG1473	amidohydrolase
FY534_RS12050	COG1438	arginine binding
FY534_RS12080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY534_RS12090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FY534_RS12105	COG2309	aminopeptidase activity
FY534_RS12110	COG2814	Major facilitator Superfamily
FY534_RS12115	COG0768	penicillin binding
FY534_RS12120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY534_RS12125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY534_RS12125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY534_RS12135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY534_RS12135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY534_RS12155	COG1045	serine acetyltransferase
FY534_RS12165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY534_RS12170	COG3459	Glycosyltransferase 36 associated
FY534_RS12175	COG3459	Glycosyltransferase 36 associated
FY534_RS12180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FY534_RS12185	COG2226	methyltransferase
FY534_RS12190	COG4496	protein, YerC YecD
FY534_RS12225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY534_RS12235	COG0247	lactate metabolic process
FY534_RS12240	COG0277	FAD linked oxidase domain protein
FY534_RS12245	COG1414	Transcriptional regulator
FY534_RS12250	COG1620	l-lactate permease
FY534_RS12270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY534_RS12295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY534_RS12300	COG2130	NADP-dependent
FY534_RS12305	COG0477	Major facilitator Superfamily
FY534_RS12310	COG0477	Major facilitator Superfamily
FY534_RS12315	COG0463	Glycosyl transferase, family 2
FY534_RS12330	COG0840	transmembrane signaling receptor activity
FY534_RS12330	COG5278	phosphoserine phosphatase activity
FY534_RS12340	COG0450	alkyl hydroperoxide reductase
FY534_RS12350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY534_RS12355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY534_RS12360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY534_RS12365	COG2337	Toxic component of a toxin-antitoxin (TA) module
FY534_RS12370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY534_RS12385	COG2197	response regulator
FY534_RS12390	COG4585	Histidine kinase
FY534_RS12405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY534_RS12410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY534_RS12410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY534_RS12415	COG0736	holo-[acyl-carrier-protein] synthase activity
FY534_RS12435	COG1012	belongs to the aldehyde dehydrogenase family
FY534_RS12440	COG1454	alcohol dehydrogenase
FY534_RS12475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY534_RS12480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY534_RS12495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY534_RS12505	COG0069	glutamate synthase activity
FY534_RS12540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FY534_RS12540	COG0662	Cupin 2, conserved barrel domain protein
FY534_RS12570	COG2814	Major facilitator Superfamily
FY534_RS12575	COG0789	Transcriptional regulator
FY534_RS12580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY534_RS12580	COG4499	WXG100 protein secretion system (Wss), protein YukC
FY534_RS12590	COG4846	Membrane protein involved in cytochrome C biogenesis
FY534_RS12595	COG1033	growth of symbiont in host cell
FY534_RS12595	COG2409	Drug exporters of the RND superfamily
FY534_RS12600	COG2409	Drug exporters of the RND superfamily
FY534_RS12600	COG1033	growth of symbiont in host cell
FY534_RS12615	COG3409	Peptidoglycan-binding domain 1 protein
FY534_RS12615	COG3773	Cell wall hydrolase
FY534_RS12620	COG1914	H( )-stimulated, divalent metal cation uptake system
FY534_RS12630	COG1321	iron dependent repressor
FY534_RS12645	COG0395	ABC-type sugar transport system, permease component
FY534_RS12650	COG1175	transmembrane transport
FY534_RS12665	COG5002	protein histidine kinase activity
FY534_RS12680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY534_RS12695	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY534_RS12705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY534_RS12710	COG1216	Glycosyl transferase, family 2
FY534_RS12720	COG0562	UDP-galactopyranose mutase
FY534_RS12735	COG1215	transferase activity, transferring glycosyl groups
FY534_RS12745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY534_RS12755	COG2203	Gaf domain
FY534_RS12755	COG2199	diguanylate cyclase activity
FY534_RS12770	COG2801	Transposase and inactivated derivatives
FY534_RS12775	COG5001	Diguanylate cyclase
FY534_RS12790	COG0484	heat shock protein binding
FY534_RS12800	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY534_RS12805	COG0768	penicillin binding
FY534_RS12810	COG0768	penicillin binding
FY534_RS12830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY534_RS12835	COG0768	penicillin binding
FY534_RS12855	COG0656	L-ascorbic acid biosynthetic process
FY534_RS12865	COG0386	Belongs to the glutathione peroxidase family
FY534_RS12870	COG1376	ErfK ybiS ycfS ynhG family protein
FY534_RS12885	COG0531	amino acid
FY534_RS12895	COG0506	proline dehydrogenase activity
FY534_RS12900	COG1136	(ABC) transporter
FY534_RS12900	COG0577	efflux transmembrane transporter activity
FY534_RS12905	COG1136	(ABC) transporter
FY534_RS12920	COG1739	Uncharacterized protein family UPF0029
FY534_RS12965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY534_RS12970	COG4786	Flagellar basal body rod
FY534_RS12975	COG4786	Flagellar basal body rod
FY534_RS12980	COG1077	Cell shape determining protein MreB Mrl
FY534_RS12985	COG1609	Transcriptional regulator
FY534_RS12990	COG0739	heme binding
FY534_RS13005	COG3852	Histidine kinase
FY534_RS13010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY534_RS13025	COG1007	ATP synthesis coupled electron transport
FY534_RS13030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY534_RS13045	COG0713	ATP synthesis coupled electron transport
FY534_RS13055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY534_RS13065	COG0649	NAD binding
FY534_RS13070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY534_RS13085	COG2226	methyltransferase
FY534_RS13090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY534_RS13095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY534_RS13100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY534_RS13105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY534_RS13110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY534_RS13115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY534_RS13120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY534_RS13125	COG0356	it plays a direct role in the translocation of protons across the membrane
FY534_RS13145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FY534_RS13150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY534_RS13155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY534_RS13160	COG2814	Major facilitator Superfamily
FY534_RS13165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY534_RS13170	COG4475	Protein of unknown function (DUF436)
FY534_RS13175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY534_RS13180	COG1971	Probably functions as a manganese efflux pump
FY534_RS13185	COG0009	L-threonylcarbamoyladenylate synthase
FY534_RS13195	COG2890	protein-(glutamine-N5) methyltransferase activity
FY534_RS13200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY534_RS13205	COG0254	rRNA binding
FY534_RS13220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY534_RS13225	COG1494	fructose-1,6-bisphosphatase
FY534_RS13230	COG0477	Major facilitator Superfamily
FY534_RS13235	COG0436	Aminotransferase
FY534_RS13240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY534_RS13245	COG3246	L-lysine catabolic process to acetate
FY534_RS13250	COG1607	acyl-coa hydrolase
FY534_RS13255	COG2204	response regulator
FY534_RS13265	COG3343	RNA polymerase activity
FY534_RS13275	COG1960	acyl-CoA dehydrogenase activity
FY534_RS13280	COG1960	acyl-CoA dehydrogenase activity
FY534_RS13285	COG1024	Enoyl-CoA hydratase
FY534_RS13290	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY534_RS13295	COG0183	Belongs to the thiolase family
FY534_RS13300	COG2181	nitrate reductase activity
FY534_RS13300	COG0247	lactate metabolic process
FY534_RS13360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY534_RS13365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY534_RS13380	COG0038	chloride channel
FY534_RS13385	COG0582	viral genome integration into host DNA
FY534_RS13400	COG5012	cobalamin binding
FY534_RS13405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY534_RS13410	COG1193	negative regulation of DNA recombination
FY534_RS13420	COG1509	lysine 2,3-aminomutase activity
FY534_RS13425	COG0604	alcohol dehydrogenase
FY534_RS13435	COG3829	transcription factor binding
FY534_RS13445	COG0010	Belongs to the arginase family
FY534_RS13450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FY534_RS13455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY534_RS13455	COG2755	lipolytic protein G-D-S-L family
FY534_RS13465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY534_RS13490	COG5416	Lipopolysaccharide assembly protein A domain
FY534_RS13505	COG1803	Methylglyoxal synthase
FY534_RS13510	COG0006	proline dipeptidase activity
FY534_RS13540	COG2030	dehydratase
FY534_RS13545	COG0788	formyltetrahydrofolate deformylase activity
FY534_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY534_RS13585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY534_RS13590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY534_RS13605	COG5002	protein histidine kinase activity
FY534_RS13610	COG0745	RESPONSE REGULATOR receiver
FY534_RS13620	COG0305	Participates in initiation and elongation during chromosome replication
FY534_RS13625	COG0359	binds to the 23S rRNA
FY534_RS13635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY534_RS13640	COG0629	single-stranded DNA binding
FY534_RS13645	COG0360	Binds together with S18 to 16S ribosomal RNA
FY534_RS13650	COG0012	GTP binding
FY534_RS13655	COG0243	molybdopterin cofactor binding
FY534_RS13660	COG4481	Protein conserved in bacteria
FY534_RS13665	COG0668	transmembrane transport
FY534_RS13685	COG1811	Na channel or pump
FY534_RS13690	COG1475	DNA binding
FY534_RS13695	COG1192	Involved in chromosome partitioning
FY534_RS13705	COG0357	Ribosomal RNA small subunit methyltransferase G
FY534_RS13710	COG0445	tRNA wobble uridine modification
FY534_RS13715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY534_RS13720	COG1847	R3H domain protein
FY534_RS13725	COG0706	membrane insertase activity
FY534_RS13730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY534_RS13735	COG0594	ribonuclease P activity
FY534_RS13740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY534_RS13850	COG0592	DNA-directed DNA polymerase activity
FY534_RS13860	COG3646	Phage regulatory protein
FY534_RS13995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FY534_RS14015	COG1247	-acetyltransferase
FY534_RS14030	COG1192	Involved in chromosome partitioning
FY534_RS14105	COG2314	TM2 domain
FY534_RS14110	COG0784	Response regulator, receiver
FY534_RS14110	COG3437	response regulator, receiver
FY534_RS14115	COG0741	lytic transglycosylase activity
FY534_RS14220	COG4974	Belongs to the 'phage' integrase family
FY534_RS14290	COG2135	peptidase activity
FY534_RS14325	COG1061	Type III restriction enzyme res subunit
FY534_RS14450	COG3344	reverse transcriptase
FY534_RS14505	COG2176	DNA-directed DNA polymerase activity