locus-tag	class	description
AFAEC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFAEC_RS00010	COG0592	DNA-directed DNA polymerase activity
AFAEC_RS00015	COG0187	DNA topoisomerase II activity
AFAEC_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFAEC_RS00030	COG1238	metal cluster binding
AFAEC_RS00040	COG0500	methyltransferase
AFAEC_RS00045	COG3842	ATPase activity
AFAEC_RS00075	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_RS00080	COG1733	regulation of RNA biosynthetic process
AFAEC_RS00100	COG2895	sulfate adenylyltransferase (ATP) activity
AFAEC_RS00105	COG0175	sulfate reduction
AFAEC_RS00110	COG0175	sulfate reduction
AFAEC_RS00125	COG1959	2 iron, 2 sulfur cluster binding
AFAEC_RS00140	COG2081	HI0933 family
AFAEC_RS00145	COG0840	transmembrane signaling receptor activity
AFAEC_RS00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_RS00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS00170	COG0840	transmembrane signaling receptor activity
AFAEC_RS00175	COG2814	Major facilitator Superfamily
AFAEC_RS00180	COG0783	Belongs to the Dps family
AFAEC_RS00185	COG0546	phosphoglycolate phosphatase activity
AFAEC_RS00195	COG1012	belongs to the aldehyde dehydrogenase family
AFAEC_RS00200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFAEC_RS00220	COG3012	SEC-C Motif Domain Protein
AFAEC_RS00230	COG3022	response to hydroperoxide
AFAEC_RS00240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AFAEC_RS00245	COG2814	Major facilitator Superfamily
AFAEC_RS00255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFAEC_RS00260	COG0233	cytoplasmic translational termination
AFAEC_RS00270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFAEC_RS00280	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_RS00285	COG0670	Belongs to the BI1 family
AFAEC_RS00370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFAEC_RS00385	COG1028	Short-chain dehydrogenase reductase Sdr
AFAEC_RS00400	COG2089	acid synthase
AFAEC_RS00405	COG3980	spore coat polysaccharide biosynthesis protein
AFAEC_RS00410	COG1083	cytidylyl-transferase
AFAEC_RS00415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_RS00420	COG1086	Polysaccharide biosynthesis protein
AFAEC_RS00430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFAEC_RS00435	COG0148	phosphopyruvate hydratase activity
AFAEC_RS00450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFAEC_RS00475	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFAEC_RS00480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFAEC_RS00485	COG0315	cyclic pyranopterin monophosphate synthase activity
AFAEC_RS00500	COG1007	ATP synthesis coupled electron transport
AFAEC_RS00510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFAEC_RS00515	COG0713	ATP synthesis coupled electron transport
AFAEC_RS00520	COG0839	Belongs to the complex I subunit 6 family
AFAEC_RS00525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS00530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFAEC_RS00550	COG0649	NAD binding
AFAEC_RS00555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS00560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS00565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS00570	COG1222	aaa ATPase
AFAEC_RS00585	COG0659	secondary active sulfate transmembrane transporter activity
AFAEC_RS00600	COG2814	Major facilitator Superfamily
AFAEC_RS00610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS00615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_RS00625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFAEC_RS00630	COG1252	NADH dehydrogenase
AFAEC_RS00640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFAEC_RS00645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_RS00650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFAEC_RS00655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_RS00660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFAEC_RS00680	COG2239	Acts as a magnesium transporter
AFAEC_RS00685	COG0445	tRNA wobble uridine modification
AFAEC_RS00695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFAEC_RS00755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFAEC_RS00760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFAEC_RS00770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFAEC_RS00775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFAEC_RS00780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFAEC_RS00795	COG0101	tRNA pseudouridine synthase activity
AFAEC_RS00805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFAEC_RS00810	COG0443	Heat shock 70 kDa protein
AFAEC_RS00820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AFAEC_RS00830	COG0688	phosphatidylethanolamine metabolic process
AFAEC_RS00835	COG3287	FIST C domain
AFAEC_RS00835	COG2199	diguanylate cyclase activity
AFAEC_RS00835	COG2200	EAL domain
AFAEC_RS00850	COG0189	ligase activity
AFAEC_RS00860	COG3118	belongs to the thioredoxin family
AFAEC_RS00895	COG0642	Histidine kinase
AFAEC_RS00900	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS00910	COG0129	dihydroxy-acid dehydratase activity
AFAEC_RS00940	COG0577	efflux transmembrane transporter activity
AFAEC_RS00940	COG1136	(ABC) transporter
AFAEC_RS00950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFAEC_RS00955	COG0585	pseudouridine synthase activity
AFAEC_RS00970	COG0793	Belongs to the peptidase S41A family
AFAEC_RS00980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFAEC_RS00985	COG0047	phosphoribosylformylglycinamidine synthase activity
AFAEC_RS00995	COG0204	Acyl-transferase
AFAEC_RS01000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFAEC_RS01005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_RS01015	COG0018	arginyl-trna synthetase
AFAEC_RS01025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFAEC_RS01035	COG0126	phosphoglycerate kinase activity
AFAEC_RS01040	COG0149	triose-phosphate isomerase activity
AFAEC_RS01045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AFAEC_RS01050	COG0019	diaminopimelate decarboxylase activity
AFAEC_RS01055	COG1605	Chorismate mutase
AFAEC_RS01055	COG0077	Prephenate dehydratase
AFAEC_RS01060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFAEC_RS01065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFAEC_RS01075	COG0424	maF-like protein
AFAEC_RS01085	COG0791	NLP P60 protein
AFAEC_RS01090	COG0791	NLP P60 protein
AFAEC_RS01105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFAEC_RS01110	COG3118	belongs to the thioredoxin family
AFAEC_RS01115	COG0492	ferredoxin-NADP+ reductase activity
AFAEC_RS01120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFAEC_RS01125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFAEC_RS01130	COG1242	4 iron, 4 sulfur cluster binding
AFAEC_RS01145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFAEC_RS01150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFAEC_RS01155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFAEC_RS01160	COG3278	Belongs to the heme-copper respiratory oxidase family
AFAEC_RS01205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFAEC_RS01210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFAEC_RS01215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFAEC_RS01220	COG0539	negative regulation of cytoplasmic translation
AFAEC_RS01220	COG1185	polyribonucleotide nucleotidyltransferase activity
AFAEC_RS01225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFAEC_RS01230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFAEC_RS01235	COG0072	phenylalanine-tRNA ligase activity
AFAEC_RS01235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_RS01240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFAEC_RS01245	COG0537	adenosine 5'-monophosphoramidase activity
AFAEC_RS01250	COG0825	malonyl-CoA metabolic process
AFAEC_RS01255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFAEC_RS01260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_RS01270	COG0602	queuosine metabolic process
AFAEC_RS01280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFAEC_RS01290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFAEC_RS01305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFAEC_RS01315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFAEC_RS01320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFAEC_RS01325	COG1074	ATP-dependent DNA helicase activity
AFAEC_RS01330	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_RS01335	COG0356	it plays a direct role in the translocation of protons across the membrane
AFAEC_RS01340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFAEC_RS01355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFAEC_RS01365	COG0586	Pfam SNARE associated Golgi protein
AFAEC_RS01370	COG0335	large ribosomal subunit rRNA binding
AFAEC_RS01375	COG0336	Belongs to the RNA methyltransferase TrmD family
AFAEC_RS01385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFAEC_RS01390	COG0251	oxidation-reduction process
AFAEC_RS01395	COG2183	response to ionizing radiation
AFAEC_RS01455	COG1840	ABC-type Fe3 transport system, periplasmic component
AFAEC_RS01500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFAEC_RS01505	COG0768	penicillin binding
AFAEC_RS01510	COG0772	Belongs to the SEDS family
AFAEC_RS01515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFAEC_RS01520	COG1968	undecaprenyl-diphosphatase activity
AFAEC_RS01525	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFAEC_RS01535	COG0314	molybdopterin synthase activity
AFAEC_RS01545	COG0174	glutamine synthetase
AFAEC_RS01555	COG0444	Belongs to the ABC transporter superfamily
AFAEC_RS01560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFAEC_RS01565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFAEC_RS01570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFAEC_RS01595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFAEC_RS01600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFAEC_RS01615	COG0250	Participates in transcription elongation, termination and antitermination
AFAEC_RS01620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFAEC_RS01625	COG0081	regulation of translation
AFAEC_RS01630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFAEC_RS01635	COG0222	ribosome binding
AFAEC_RS01640	COG0085	RNA polymerase activity
AFAEC_RS01645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFAEC_RS01660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_RS01665	COG1116	anion transmembrane transporter activity
AFAEC_RS01680	COG4771	TonB-dependent receptor
AFAEC_RS01690	COG0450	alkyl hydroperoxide reductase
AFAEC_RS01695	COG2814	Major facilitator Superfamily
AFAEC_RS01705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFAEC_RS01710	COG0049	tRNA binding
AFAEC_RS01715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFAEC_RS01720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFAEC_RS01725	COG0497	DNA recombination
AFAEC_RS01730	COG0840	transmembrane signaling receptor activity
AFAEC_RS01745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFAEC_RS01755	COG0752	glycyl-tRNA synthetase alpha subunit
AFAEC_RS01760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFAEC_RS01770	COG1519	Transferase
AFAEC_RS01770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFAEC_RS01775	COG0564	pseudouridine synthase activity
AFAEC_RS01780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFAEC_RS01785	COG0228	four-way junction DNA binding
AFAEC_RS01790	COG1837	Belongs to the UPF0109 family
AFAEC_RS01795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFAEC_RS01815	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS01825	COG4786	Flagellar basal body rod
AFAEC_RS01830	COG1815	bacterial-type flagellum-dependent cell motility
AFAEC_RS01835	COG1766	The M ring may be actively involved in energy transduction
AFAEC_RS01840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_RS01850	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_RS01860	COG4786	Flagellar basal body rod
AFAEC_RS01885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFAEC_RS01905	COG1419	protein localization to endoplasmic reticulum
AFAEC_RS01910	COG0455	bacterial-type flagellum organization
AFAEC_RS01920	COG1677	Flagellar hook-basal body complex protein FliE
AFAEC_RS01940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_RS01950	COG1157	protein secretion by the type III secretion system
AFAEC_RS01955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFAEC_RS01960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_RS01970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AFAEC_RS01980	COG1970	mechanosensitive ion channel activity
AFAEC_RS02005	COG2030	dehydratase
AFAEC_RS02020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFAEC_RS02025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFAEC_RS02030	COG0542	response to heat
AFAEC_RS02080	COG4773	Receptor
AFAEC_RS02085	COG4753	response regulator
AFAEC_RS02085	COG2207	Transcriptional regulator
AFAEC_RS02090	COG3852	Histidine kinase
AFAEC_RS02100	COG0277	FAD linked oxidase domain protein
AFAEC_RS02110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFAEC_RS02115	COG2226	methyltransferase
AFAEC_RS02135	COG1739	Uncharacterized protein family UPF0029
AFAEC_RS02155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFAEC_RS02160	COG0697	spore germination
AFAEC_RS02165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFAEC_RS02170	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFAEC_RS02185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFAEC_RS02190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFAEC_RS02195	COG0284	orotidine-5'-phosphate decarboxylase activity
AFAEC_RS02255	COG0483	inositol monophosphate 1-phosphatase activity
AFAEC_RS02260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFAEC_RS02285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AFAEC_RS02325	COG1216	Glycosyl transferase, family 2
AFAEC_RS02335	COG1696	Membrane protein involved in D-alanine export
AFAEC_RS02345	COG1696	Membrane protein involved in D-alanine export
AFAEC_RS02360	COG0438	transferase activity, transferring glycosyl groups
AFAEC_RS02385	COG0859	PFAM glycosyl transferase family 9
AFAEC_RS02400	COG1368	sulfuric ester hydrolase activity
AFAEC_RS02405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFAEC_RS02410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFAEC_RS02410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFAEC_RS02420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFAEC_RS02430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFAEC_RS02440	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFAEC_RS02455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFAEC_RS02465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFAEC_RS02520	COG1570	exodeoxyribonuclease VII activity
AFAEC_RS02525	COG0835	chemotaxis
AFAEC_RS02540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFAEC_RS02545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFAEC_RS02560	COG0459	protein refolding
AFAEC_RS02570	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS02575	COG2205	protein histidine kinase activity
AFAEC_RS02585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFAEC_RS02590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFAEC_RS02595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFAEC_RS02600	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_RS02605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFAEC_RS02615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFAEC_RS02620	COG2264	protein methyltransferase activity
AFAEC_RS02625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFAEC_RS02640	COG0628	permease
AFAEC_RS02645	COG2255	four-way junction helicase activity
AFAEC_RS02650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFAEC_RS02655	COG0159	tryptophan synthase activity
AFAEC_RS02660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFAEC_RS02670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFAEC_RS02685	COG0716	FMN binding
AFAEC_RS02710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFAEC_RS02720	COG4191	Histidine kinase
AFAEC_RS02750	COG0739	heme binding
AFAEC_RS02795	COG1475	DNA binding
AFAEC_RS02800	COG0270	DNA (cytosine-5-)-methyltransferase activity
AFAEC_RS02820	COG5499	transcription regulator containing HTH domain
AFAEC_RS02865	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_RS03030	COG0739	heme binding
AFAEC_RS03030	COG0741	lytic transglycosylase activity
AFAEC_RS03030	COG1196	nuclear chromosome segregation
AFAEC_RS03035	COG0582	viral genome integration into host DNA
AFAEC_RS03060	COG2326	polyphosphate kinase activity
AFAEC_RS03065	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFAEC_RS03070	COG0740	serine-type endopeptidase activity
AFAEC_RS03075	COG0242	peptide deformylase activity
AFAEC_RS03085	COG0606	chelatase, subunit chli
AFAEC_RS03090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_RS03105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AFAEC_RS03115	COG2095	MarC family integral membrane protein
AFAEC_RS03120	COG3706	GGDEF domain
AFAEC_RS03125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFAEC_RS03130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFAEC_RS03150	COG0481	GTPase activity
AFAEC_RS03165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFAEC_RS03175	COG0482	sulfurtransferase activity
AFAEC_RS03180	COG0482	sulfurtransferase activity
AFAEC_RS03185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFAEC_RS03190	COG0006	proline dipeptidase activity
AFAEC_RS03195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFAEC_RS03200	COG0402	S-adenosylhomocysteine deaminase activity
AFAEC_RS03205	COG0616	signal peptide processing
AFAEC_RS03215	COG0280	phosphate acetyltransferase
AFAEC_RS03220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFAEC_RS03225	COG2176	DNA-directed DNA polymerase activity
AFAEC_RS03235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFAEC_RS03255	COG2176	DNA-directed DNA polymerase activity
AFAEC_RS03265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFAEC_RS03275	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS03325	COG1546	Belongs to the CinA family
AFAEC_RS03325	COG1058	Belongs to the CinA family
AFAEC_RS03330	COG0579	oxidoreductase
AFAEC_RS03335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFAEC_RS03350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFAEC_RS03355	COG0052	Belongs to the universal ribosomal protein uS2 family
AFAEC_RS03360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFAEC_RS03365	COG1136	(ABC) transporter
AFAEC_RS03375	COG0194	GDP metabolic process
AFAEC_RS03380	COG5002	protein histidine kinase activity
AFAEC_RS03380	COG5001	Diguanylate cyclase
AFAEC_RS03385	COG2217	Heavy metal translocating P-type atpase
AFAEC_RS03400	COG4608	Belongs to the ABC transporter superfamily
AFAEC_RS03405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFAEC_RS03410	COG1227	inorganic diphosphatase activity
AFAEC_RS03415	COG0668	transmembrane transport
AFAEC_RS03420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFAEC_RS03430	COG2207	Transcriptional regulator
AFAEC_RS03435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_RS03460	COG4773	Receptor
AFAEC_RS03470	COG0010	Belongs to the arginase family
AFAEC_RS03515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS03520	COG0577	efflux transmembrane transporter activity
AFAEC_RS03520	COG1136	(ABC) transporter
AFAEC_RS03525	COG1538	Outer membrane efflux protein
AFAEC_RS03535	COG1278	Cold shock
AFAEC_RS03540	COG4335	DNA alkylation repair
AFAEC_RS03545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFAEC_RS03575	COG2995	paraquat-inducible protein a
AFAEC_RS03585	COG0753	catalase activity
AFAEC_RS03595	COG3111	PFAM Bacterial OB fold (BOF) protein
AFAEC_RS03600	COG0642	Histidine kinase
AFAEC_RS03605	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS03645	COG0326	Molecular chaperone. Has ATPase activity
AFAEC_RS03655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFAEC_RS03660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFAEC_RS03665	COG0840	transmembrane signaling receptor activity
AFAEC_RS03670	COG0840	transmembrane signaling receptor activity
AFAEC_RS03680	COG0840	transmembrane signaling receptor activity
AFAEC_RS03690	COG0513	Belongs to the DEAD box helicase family
AFAEC_RS03700	COG0259	pyridoxamine-phosphate oxidase activity
AFAEC_RS03710	COG5002	protein histidine kinase activity
AFAEC_RS03715	COG1121	(ABC) transporter
AFAEC_RS03720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFAEC_RS03725	COG2996	Protein conserved in bacteria
AFAEC_RS03730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFAEC_RS03740	COG0114	fumarate hydratase activity
AFAEC_RS03755	COG0210	DNA helicase
AFAEC_RS03760	COG0475	glutathione-regulated potassium exporter activity
AFAEC_RS03760	COG0569	domain protein
AFAEC_RS03765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFAEC_RS03790	COG3258	Cytochrome c
AFAEC_RS03885	COG1921	L-seryl-tRNASec selenium transferase activity
AFAEC_RS03915	COG4774	siderophore transport
AFAEC_RS03925	COG0709	Synthesizes selenophosphate from selenide and ATP
AFAEC_RS03930	COG1305	Transglutaminase-like
AFAEC_RS03960	COG1309	transcriptional regulator
AFAEC_RS03965	COG4565	transcriptional regulatory protein
AFAEC_RS04000	COG3383	formate dehydrogenase (NAD+) activity
AFAEC_RS04005	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_RS04015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFAEC_RS04025	COG0303	'Molybdopterin
AFAEC_RS04030	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFAEC_RS04040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFAEC_RS04045	COG0306	phosphate transporter
AFAEC_RS04055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFAEC_RS04060	COG0328	RNA-DNA hybrid ribonuclease activity
AFAEC_RS04065	COG0840	transmembrane signaling receptor activity
AFAEC_RS04080	COG0640	Transcriptional regulator
AFAEC_RS04085	COG2217	Heavy metal translocating P-type atpase
AFAEC_RS04120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFAEC_RS04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFAEC_RS04130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFAEC_RS04135	COG0095	Lipoate-protein ligase
AFAEC_RS04140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFAEC_RS04150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFAEC_RS04155	COG0519	Catalyzes the synthesis of GMP from XMP
AFAEC_RS04155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFAEC_RS04180	COG2267	carboxylic ester hydrolase activity
AFAEC_RS04195	COG1696	Membrane protein involved in D-alanine export
AFAEC_RS04200	COG0116	Belongs to the methyltransferase superfamily
AFAEC_RS04200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFAEC_RS04210	COG2989	Protein conserved in bacteria
AFAEC_RS04225	COG4535	Mg2 and Co2 transporter CorC
AFAEC_RS04230	COG0628	permease
AFAEC_RS04245	COG3501	Rhs element vgr protein
AFAEC_RS04260	COG3706	GGDEF domain
AFAEC_RS04270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFAEC_RS04290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFAEC_RS04290	COG0301	tRNA thio-modification
AFAEC_RS04305	COG2814	Major facilitator Superfamily
AFAEC_RS04325	COG2354	Protein conserved in bacteria
AFAEC_RS04330	COG0726	polysaccharide deacetylase
AFAEC_RS04335	COG2081	HI0933 family
AFAEC_RS04360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFAEC_RS04365	COG2171	N-acyltransferase activity
AFAEC_RS04380	COG0488	(ABC) transporter
AFAEC_RS04385	COG3135	benzoate transporter
AFAEC_RS04390	COG2258	MOSC domain
AFAEC_RS04395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFAEC_RS04405	COG1335	isochorismatase
AFAEC_RS04415	COG1944	ATP diphosphatase activity
AFAEC_RS04420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFAEC_RS04435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFAEC_RS04450	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS04465	COG0189	ligase activity
AFAEC_RS04465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFAEC_RS04510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AFAEC_RS04530	COG4263	nitrous-oxide reductase activity
AFAEC_RS04545	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_RS04560	COG0348	domain, Protein
AFAEC_RS04565	COG1122	ATPase activity
AFAEC_RS04585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFAEC_RS04590	COG1611	Belongs to the LOG family
AFAEC_RS04610	COG0217	transcriptional regulatory protein
AFAEC_RS04640	COG1049	propionate catabolic process, 2-methylcitrate cycle
AFAEC_RS04645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFAEC_RS04655	COG1451	nucleotide metabolic process
AFAEC_RS04675	COG2884	Cell division ATP-binding protein ftsE
AFAEC_RS04680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFAEC_RS04690	COG0564	pseudouridine synthase activity
AFAEC_RS04695	COG0772	Belongs to the SEDS family
AFAEC_RS04700	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AFAEC_RS04705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFAEC_RS04710	COG3123	guanosine phosphorylase activity
AFAEC_RS04725	COG1090	epimerase
AFAEC_RS04740	COG3275	phosphorelay sensor kinase activity
AFAEC_RS04745	COG3279	Response regulator of the LytR AlgR family
AFAEC_RS04755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFAEC_RS04760	COG0071	Belongs to the small heat shock protein (HSP20) family
AFAEC_RS04770	COG1132	(ABC) transporter
AFAEC_RS04780	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS04785	COG0642	Histidine kinase
AFAEC_RS04815	COG0653	protein targeting
AFAEC_RS04820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFAEC_RS04830	COG0546	phosphoglycolate phosphatase activity
AFAEC_RS04855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFAEC_RS04865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFAEC_RS04870	COG0697	spore germination
AFAEC_RS04875	COG0513	Belongs to the DEAD box helicase family
AFAEC_RS04885	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS04920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AFAEC_RS04925	COG2363	Small membrane protein
AFAEC_RS04930	COG1666	GTP binding
AFAEC_RS04935	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS04940	COG0642	Histidine kinase
AFAEC_RS04945	COG0494	nUDIX hydrolase
AFAEC_RS04960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFAEC_RS04965	COG0135	phosphoribosylanthranilate isomerase activity
AFAEC_RS04970	COG2176	DNA-directed DNA polymerase activity
AFAEC_RS04990	COG0667	Aldo Keto reductase
AFAEC_RS05000	COG5000	phosphorelay sensor kinase activity
AFAEC_RS05020	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS05030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFAEC_RS05035	COG0066	3-isopropylmalate dehydratase activity
AFAEC_RS05040	COG0473	3-isopropylmalate dehydrogenase activity
AFAEC_RS05055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFAEC_RS05060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFAEC_RS05065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFAEC_RS05070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFAEC_RS05075	COG0202	RNA polymerase activity
AFAEC_RS05080	COG0203	ribosomal protein L17
AFAEC_RS05085	COG0154	amidase activity
AFAEC_RS05090	COG0517	IMP dehydrogenase activity
AFAEC_RS05090	COG0516	GMP reductase activity
AFAEC_RS05095	COG0840	transmembrane signaling receptor activity
AFAEC_RS05105	COG3706	GGDEF domain
AFAEC_RS05110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFAEC_RS05125	COG0788	formyltetrahydrofolate deformylase activity
AFAEC_RS05130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFAEC_RS05145	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS05160	COG3501	Rhs element vgr protein
AFAEC_RS05180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFAEC_RS05190	COG1393	Belongs to the ArsC family
AFAEC_RS05200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFAEC_RS05210	COG0849	cell division
AFAEC_RS05215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFAEC_RS05220	COG2391	methyltransferase activity
AFAEC_RS05230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFAEC_RS05235	COG1722	exodeoxyribonuclease VII activity
AFAEC_RS05240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFAEC_RS05250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFAEC_RS05270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFAEC_RS05280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_RS05285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFAEC_RS05295	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFAEC_RS05300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_RS05315	COG0454	-acetyltransferase
AFAEC_RS05330	COG4774	siderophore transport
AFAEC_RS05340	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AFAEC_RS05355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFAEC_RS05360	COG0298	carbon dioxide binding
AFAEC_RS05375	COG2084	Dehydrogenase
AFAEC_RS05385	COG0309	Hydrogenase expression formation protein (HypE)
AFAEC_RS05400	COG0310	cobalt ion transport
AFAEC_RS05425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_RS05435	COG1696	Membrane protein involved in D-alanine export
AFAEC_RS05440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFAEC_RS05445	COG0137	argininosuccinate synthase activity
AFAEC_RS05455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFAEC_RS05465	COG1137	ATPase activity
AFAEC_RS05665	COG0582	viral genome integration into host DNA
AFAEC_RS05680	COG0339	signal peptide processing
AFAEC_RS05685	COG2890	protein-(glutamine-N5) methyltransferase activity
AFAEC_RS05690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFAEC_RS05695	COG0494	nUDIX hydrolase
AFAEC_RS05700	COG0527	aspartate kinase activity
AFAEC_RS05715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFAEC_RS05730	COG0166	Belongs to the GPI family
AFAEC_RS05750	COG0708	Exodeoxyribonuclease III
AFAEC_RS05760	COG0500	methyltransferase
AFAEC_RS05765	COG1333	cytochrome c biogenesis protein
AFAEC_RS05765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFAEC_RS05770	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFAEC_RS05775	COG3287	FIST C domain
AFAEC_RS05775	COG2200	EAL domain
AFAEC_RS05775	COG2199	diguanylate cyclase activity
AFAEC_RS05790	COG1253	flavin adenine dinucleotide binding
AFAEC_RS05795	COG1193	negative regulation of DNA recombination
AFAEC_RS05800	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_RS05835	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AFAEC_RS05840	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AFAEC_RS05845	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AFAEC_RS05870	COG0484	heat shock protein binding
AFAEC_RS05890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFAEC_RS05895	COG5001	Diguanylate cyclase
AFAEC_RS05900	COG2203	Gaf domain
AFAEC_RS05900	COG5001	Diguanylate cyclase
AFAEC_RS05900	COG4251	negative regulation of phosphorylation
AFAEC_RS05900	COG3706	GGDEF domain
AFAEC_RS05905	COG0287	Prephenate dehydrogenase
AFAEC_RS05910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_RS05915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFAEC_RS05920	COG0612	Peptidase, M16
AFAEC_RS05925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFAEC_RS05950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFAEC_RS05960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_RS05960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFAEC_RS05975	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AFAEC_RS05980	COG2201	protein-glutamate methylesterase activity
AFAEC_RS05985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AFAEC_RS05990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFAEC_RS05995	COG2198	Histidine kinase
AFAEC_RS05995	COG0643	Histidine kinase
AFAEC_RS06000	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS06005	COG1185	polyribonucleotide nucleotidyltransferase activity
AFAEC_RS06015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AFAEC_RS06035	COG0659	secondary active sulfate transmembrane transporter activity
AFAEC_RS06040	COG1160	GTP binding
AFAEC_RS06055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFAEC_RS06085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFAEC_RS06085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AFAEC_RS06090	COG2201	protein-glutamate methylesterase activity
AFAEC_RS06105	COG0484	heat shock protein binding
AFAEC_RS06110	COG0789	Transcriptional regulator
AFAEC_RS06125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_RS06125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFAEC_RS06130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFAEC_RS06135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFAEC_RS06140	COG4774	siderophore transport
AFAEC_RS06145	COG1663	tetraacyldisaccharide 4'-kinase activity
AFAEC_RS06150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_RS06155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFAEC_RS06170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AFAEC_RS06175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFAEC_RS06180	COG0805	protein transport
AFAEC_RS06185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFAEC_RS06190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFAEC_RS06205	COG0247	lactate metabolic process
AFAEC_RS06205	COG2181	nitrate reductase activity
AFAEC_RS06210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFAEC_RS06225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFAEC_RS06225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFAEC_RS06230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFAEC_RS06245	COG0275	rRNA processing
AFAEC_RS06255	COG0776	regulation of translation
AFAEC_RS06270	COG3328	transposase activity
AFAEC_RS06280	COG3328	transposase activity
AFAEC_RS06320	COG0357	Ribosomal RNA small subunit methyltransferase G
AFAEC_RS06325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_RS06330	COG0113	porphobilinogen synthase activity
AFAEC_RS06345	COG0861	Integral membrane protein TerC family
AFAEC_RS06350	COG1114	Component of the transport system for branched-chain amino acids
AFAEC_RS06360	COG1196	nuclear chromosome segregation
AFAEC_RS06360	COG1674	ftsk spoiiie
AFAEC_RS06365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFAEC_RS06370	COG0440	acetolactate synthase activity
AFAEC_RS06375	COG0028	Belongs to the TPP enzyme family
AFAEC_RS06385	COG0248	Ppx GppA phosphatase
AFAEC_RS06395	COG5001	Diguanylate cyclase
AFAEC_RS06395	COG4251	negative regulation of phosphorylation
AFAEC_RS06395	COG3706	GGDEF domain
AFAEC_RS06395	COG2203	Gaf domain
AFAEC_RS06410	COG3118	belongs to the thioredoxin family
AFAEC_RS06420	COG0037	tRNA processing
AFAEC_RS06430	COG0303	'Molybdopterin
AFAEC_RS06440	COG2321	neutral zinc metallopeptidase
AFAEC_RS06445	COG1322	Protein conserved in bacteria
AFAEC_RS06450	COG0501	Belongs to the peptidase M48B family
AFAEC_RS06460	COG0824	Thioesterase
AFAEC_RS06470	COG1086	Polysaccharide biosynthesis protein
AFAEC_RS06475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFAEC_RS06480	COG0110	maltose O-acetyltransferase activity
AFAEC_RS06485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFAEC_RS06490	COG0438	transferase activity, transferring glycosyl groups
AFAEC_RS06495	COG0438	transferase activity, transferring glycosyl groups
AFAEC_RS06500	COG0367	asparagine synthase
AFAEC_RS06530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFAEC_RS06535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFAEC_RS06565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AFAEC_RS06570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AFAEC_RS06620	COG0840	transmembrane signaling receptor activity
AFAEC_RS06625	COG0322	excinuclease ABC activity
AFAEC_RS06630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFAEC_RS06645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFAEC_RS06655	COG0768	penicillin binding
AFAEC_RS06660	COG1338	Plays a role in the flagellum-specific transport system
AFAEC_RS06665	COG3437	response regulator, receiver
AFAEC_RS06665	COG0784	Response regulator, receiver
AFAEC_RS06675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS06690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFAEC_RS06695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFAEC_RS06700	COG0488	(ABC) transporter
AFAEC_RS06710	COG0778	Nitroreductase
AFAEC_RS06715	COG2249	NAD(P)H dehydrogenase (quinone) activity
AFAEC_RS06720	COG1733	regulation of RNA biosynthetic process
AFAEC_RS06730	COG2855	membrane
AFAEC_RS06735	COG0583	DNA-binding transcription factor activity
AFAEC_RS06745	COG1881	PFAM PEBP family protein
AFAEC_RS06755	COG0642	Histidine kinase
AFAEC_RS06770	COG3258	Cytochrome c
AFAEC_RS06785	COG2076	Multidrug Resistance protein
AFAEC_RS06790	COG1119	ATPase activity
AFAEC_RS06800	COG0754	glutathionylspermidine amidase activity
AFAEC_RS06805	COG0840	transmembrane signaling receptor activity
AFAEC_RS06820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFAEC_RS06835	COG0840	transmembrane signaling receptor activity
AFAEC_RS06850	COG0840	transmembrane signaling receptor activity
AFAEC_RS06855	COG0840	transmembrane signaling receptor activity
AFAEC_RS06860	COG0840	transmembrane signaling receptor activity
AFAEC_RS06865	COG1595	DNA-templated transcription, initiation
AFAEC_RS06880	COG1472	Belongs to the glycosyl hydrolase 3 family
AFAEC_RS06890	COG0484	heat shock protein binding
AFAEC_RS06905	COG1607	acyl-coa hydrolase
AFAEC_RS06910	COG0456	acetyltransferase
AFAEC_RS06915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFAEC_RS06930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFAEC_RS06935	COG0131	Imidazoleglycerol-phosphate dehydratase
AFAEC_RS06940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AFAEC_RS06945	COG0741	lytic transglycosylase activity
AFAEC_RS06945	COG1388	LysM domain
AFAEC_RS06950	COG0084	hydrolase, TatD family'
AFAEC_RS06965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFAEC_RS06970	COG0359	binds to the 23S rRNA
AFAEC_RS06980	COG0163	prenyltransferase activity
AFAEC_RS06985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFAEC_RS06990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFAEC_RS06995	COG0124	histidyl-tRNA synthetase
AFAEC_RS07000	COG1166	arginine decarboxylase activity
AFAEC_RS07005	COG1045	serine acetyltransferase
AFAEC_RS07010	COG0730	response to heat
AFAEC_RS07020	COG0492	ferredoxin-NADP+ reductase activity
AFAEC_RS07035	COG3706	GGDEF domain
AFAEC_RS07040	COG0157	Belongs to the NadC ModD family
AFAEC_RS07050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFAEC_RS07055	COG0742	ribosomal rna small subunit methyltransferase
AFAEC_RS07060	COG1418	mRNA catabolic process
AFAEC_RS07075	COG0552	protein localization to endoplasmic reticulum
AFAEC_RS07090	COG1858	cytochrome C peroxidase
AFAEC_RS07115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFAEC_RS07125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFAEC_RS07130	COG0735	belongs to the Fur family
AFAEC_RS07140	COG0728	peptidoglycan biosynthetic process
AFAEC_RS07145	COG1132	(ABC) transporter
AFAEC_RS07150	COG0167	dihydroorotate dehydrogenase activity
AFAEC_RS07160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFAEC_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
AFAEC_RS07170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFAEC_RS07175	COG0750	zinc metalloprotease
AFAEC_RS07180	COG0840	transmembrane signaling receptor activity
AFAEC_RS07190	COG0840	transmembrane signaling receptor activity
AFAEC_RS07215	COG3501	Rhs element vgr protein
AFAEC_RS07220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFAEC_RS07225	COG1942	4-Oxalocrotonate Tautomerase
AFAEC_RS07230	COG0583	DNA-binding transcription factor activity
AFAEC_RS07245	COG5001	Diguanylate cyclase
AFAEC_RS07245	COG3706	GGDEF domain
AFAEC_RS07245	COG2203	Gaf domain
AFAEC_RS07245	COG4251	negative regulation of phosphorylation
AFAEC_RS07255	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS07260	COG0642	Histidine kinase
AFAEC_RS07265	COG2081	HI0933 family
AFAEC_RS07275	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS07290	COG1692	metallophosphoesterase
AFAEC_RS07295	COG0134	indole-3-glycerol-phosphate synthase activity
AFAEC_RS07305	COG0727	PFAM Uncharacterised protein family (UPF0153)
AFAEC_RS07310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AFAEC_RS07320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFAEC_RS07320	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFAEC_RS07325	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFAEC_RS07335	COG1979	alcohol dehydrogenase
AFAEC_RS07360	COG2207	Transcriptional regulator
AFAEC_RS07365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFAEC_RS07380	COG0563	adenylate kinase activity
AFAEC_RS07400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFAEC_RS07410	COG1573	uracil-dna glycosylase
AFAEC_RS07415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFAEC_RS07420	COG0024	Methionine aminopeptidase
AFAEC_RS07425	COG0201	protein transport
AFAEC_RS07430	COG0200	Binds to the 23S rRNA
AFAEC_RS07435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFAEC_RS07440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFAEC_RS07445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFAEC_RS07450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFAEC_RS07455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFAEC_RS07460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFAEC_RS07465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFAEC_RS07470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFAEC_RS07475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFAEC_RS07480	COG0255	Belongs to the universal ribosomal protein uL29 family
AFAEC_RS07485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFAEC_RS07490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFAEC_RS07495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFAEC_RS07500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFAEC_RS07505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFAEC_RS07510	COG0089	rRNA binding
AFAEC_RS07515	COG0088	Forms part of the polypeptide exit tunnel
AFAEC_RS07520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFAEC_RS07525	COG0051	transcription antitermination factor activity, RNA binding
AFAEC_RS07540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFAEC_RS07550	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFAEC_RS07555	COG0632	four-way junction helicase activity
AFAEC_RS07560	COG0840	transmembrane signaling receptor activity
AFAEC_RS07570	COG0585	pseudouridine synthase activity
AFAEC_RS07575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFAEC_RS07585	COG3123	guanosine phosphorylase activity
AFAEC_RS07605	COG0012	GTP binding
AFAEC_RS07610	COG1966	Carbon starvation protein
AFAEC_RS07630	COG0500	methyltransferase
AFAEC_RS07635	COG4771	TonB-dependent receptor
AFAEC_RS07675	COG1136	(ABC) transporter
AFAEC_RS07675	COG0577	efflux transmembrane transporter activity
AFAEC_RS07680	COG0577	efflux transmembrane transporter activity
AFAEC_RS07680	COG1136	(ABC) transporter
AFAEC_RS07695	COG0811	peptide transport
AFAEC_RS07700	COG0848	biopolymer transport protein
AFAEC_RS07710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFAEC_RS07720	COG0133	tryptophan synthase activity
AFAEC_RS07725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFAEC_RS07730	COG1793	dna ligase
AFAEC_RS07740	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_RS07745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFAEC_RS07760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFAEC_RS07765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFAEC_RS07775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFAEC_RS07780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFAEC_RS07785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFAEC_RS07795	COG0528	UMP kinase activity
AFAEC_RS07800	COG1758	RNA polymerase activity
AFAEC_RS07805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFAEC_RS07810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFAEC_RS07820	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFAEC_RS07825	COG3501	Rhs element vgr protein
AFAEC_RS07855	COG0193	aminoacyl-tRNA hydrolase activity
AFAEC_RS07860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFAEC_RS07865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFAEC_RS07870	COG0681	Belongs to the peptidase S26 family
AFAEC_RS07875	COG0698	ribose 5-phosphate isomerase
AFAEC_RS07885	COG0840	transmembrane signaling receptor activity
AFAEC_RS07895	COG0840	transmembrane signaling receptor activity
AFAEC_RS07910	COG2831	hemolysin activation secretion protein
AFAEC_RS07930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFAEC_RS07935	COG0556	nucleotide-excision repair
AFAEC_RS07950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFAEC_RS07955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFAEC_RS07960	COG0784	Response regulator, receiver
AFAEC_RS07960	COG0835	chemotaxis
AFAEC_RS07965	COG0165	Argininosuccinate lyase
AFAEC_RS07970	COG3706	GGDEF domain
AFAEC_RS07975	COG3448	diguanylate cyclase activity
AFAEC_RS07975	COG4175	Glycine betaine
AFAEC_RS07985	COG0719	Fe-S assembly protein
AFAEC_RS07990	COG0396	ATPase activity
AFAEC_RS08000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFAEC_RS08005	COG2166	iron-sulfur cluster assembly
AFAEC_RS08030	COG0439	Biotin carboxylase
AFAEC_RS08045	COG3706	GGDEF domain
AFAEC_RS08050	COG0840	transmembrane signaling receptor activity
AFAEC_RS08055	COG0840	transmembrane signaling receptor activity
AFAEC_RS08065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFAEC_RS08070	COG0840	transmembrane signaling receptor activity
AFAEC_RS08075	COG0840	transmembrane signaling receptor activity
AFAEC_RS08095	COG0535	radical SAM domain protein
AFAEC_RS08105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFAEC_RS08115	COG2010	Cytochrome c
AFAEC_RS08125	COG3256	nitric oxide reductase
AFAEC_RS08130	COG2010	Cytochrome c
AFAEC_RS08145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFAEC_RS08150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_RS08155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFAEC_RS08175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFAEC_RS08180	COG2814	Major facilitator Superfamily
AFAEC_RS08190	COG2200	EAL domain
AFAEC_RS08195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AFAEC_RS08215	COG0525	valine-tRNA ligase activity
AFAEC_RS08220	COG1846	Transcriptional regulator
AFAEC_RS08260	COG1027	Aspartate ammonia-lyase
AFAEC_RS08265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFAEC_RS08270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFAEC_RS08275	COG1047	Peptidyl-prolyl cis-trans
AFAEC_RS08290	COG0823	Involved in the tonB-independent uptake of proteins
AFAEC_RS08300	COG0848	biopolymer transport protein
AFAEC_RS08305	COG0811	peptide transport
AFAEC_RS08310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFAEC_RS08315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFAEC_RS08320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFAEC_RS08325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFAEC_RS08330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFAEC_RS08335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFAEC_RS08345	COG1475	DNA binding
AFAEC_RS08350	COG1192	Involved in chromosome partitioning
AFAEC_RS08365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFAEC_RS08370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFAEC_RS08375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFAEC_RS08380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFAEC_RS08385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFAEC_RS08390	COG0358	DNA primase activity
AFAEC_RS08400	COG0571	ribonuclease III activity
AFAEC_RS08405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFAEC_RS08415	COG2194	sulfuric ester hydrolase activity
AFAEC_RS08440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFAEC_RS08445	COG3755	Protein conserved in bacteria
AFAEC_RS08460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFAEC_RS08465	COG0642	Histidine kinase
AFAEC_RS08470	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS08490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFAEC_RS08500	COG0706	membrane insertase activity
AFAEC_RS08505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFAEC_RS08510	COG0594	ribonuclease P activity
AFAEC_RS08515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFAEC_RS08520	COG0542	response to heat
AFAEC_RS08525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFAEC_RS08530	COG2326	polyphosphate kinase activity
AFAEC_RS08545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFAEC_RS08605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFAEC_RS08620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFAEC_RS08630	COG0138	bifunctional purine biosynthesis protein purh
AFAEC_RS08635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFAEC_RS08645	COG0739	heme binding
AFAEC_RS08645	COG0741	lytic transglycosylase activity
AFAEC_RS08645	COG1196	nuclear chromosome segregation
AFAEC_RS08655	COG0598	Magnesium transport protein CorA
AFAEC_RS08660	COG1459	type II secretion system
AFAEC_RS08680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFAEC_RS08695	COG0626	cystathionine gamma-synthase activity
AFAEC_RS08715	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AFAEC_RS08720	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFAEC_RS08730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFAEC_RS08745	COG1858	cytochrome C peroxidase
AFAEC_RS08775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFAEC_RS08845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFAEC_RS08875	COG3179	chitinase
AFAEC_RS08880	COG3501	Rhs element vgr protein
AFAEC_RS08885	COG0515	serine threonine protein kinase
AFAEC_RS08885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFAEC_RS09000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFAEC_RS09035	COG0285	dihydrofolate synthase activity
AFAEC_RS09045	COG0495	leucyl-tRNA aminoacylation
AFAEC_RS09055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFAEC_RS09060	COG1360	Flagellar Motor Protein
AFAEC_RS09075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFAEC_RS09080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFAEC_RS09085	COG1862	Preprotein translocase
AFAEC_RS09090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFAEC_RS09095	COG0300	oxidoreductase activity
AFAEC_RS09115	COG0617	tRNA 3'-terminal CCA addition
AFAEC_RS09120	COG0668	transmembrane transport
AFAEC_RS09125	COG0442	prolyl-tRNA aminoacylation
AFAEC_RS09130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFAEC_RS09135	COG0142	geranyltranstransferase activity
AFAEC_RS09145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFAEC_RS09150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFAEC_RS09160	COG0811	peptide transport
AFAEC_RS09165	COG0848	biopolymer transport protein
AFAEC_RS09180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFAEC_RS09185	COG2267	carboxylic ester hydrolase activity
AFAEC_RS09205	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AFAEC_RS09235	COG0039	L-malate dehydrogenase activity
AFAEC_RS09240	COG0730	response to heat
AFAEC_RS09280	COG2204	response regulator
AFAEC_RS09290	COG0191	fructose-bisphosphate aldolase activity
AFAEC_RS09295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFAEC_RS09300	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS09305	COG0642	Histidine kinase
AFAEC_RS09315	COG2404	hydrolase activity, acting on ester bonds
AFAEC_RS09325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFAEC_RS09330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFAEC_RS09335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFAEC_RS09350	COG0243	molybdopterin cofactor binding
AFAEC_RS09355	COG0437	4 iron, 4 sulfur cluster binding
AFAEC_RS09360	COG0348	domain, Protein
AFAEC_RS09365	COG3043	anaerobic respiration
AFAEC_RS09385	COG0840	transmembrane signaling receptor activity
AFAEC_RS09390	COG5001	Diguanylate cyclase
AFAEC_RS09390	COG5002	protein histidine kinase activity
AFAEC_RS09400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFAEC_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS09415	COG1131	(ABC) transporter
AFAEC_RS09420	COG0842	Transport permease protein
AFAEC_RS09425	COG0842	Transport permease protein
AFAEC_RS09440	COG1609	Transcriptional regulator
AFAEC_RS09440	COG2207	Transcriptional regulator
AFAEC_RS09445	COG4771	TonB-dependent receptor
AFAEC_RS09455	COG1132	(ABC) transporter
AFAEC_RS09470	COG1971	Probably functions as a manganese efflux pump
AFAEC_RS09480	COG3706	GGDEF domain
AFAEC_RS09490	COG0840	transmembrane signaling receptor activity
AFAEC_RS09495	COG4999	Histidine kinase
AFAEC_RS09495	COG3850	Histidine kinase
AFAEC_RS09495	COG3437	response regulator, receiver
AFAEC_RS09495	COG2205	protein histidine kinase activity
AFAEC_RS09510	COG3204	pilus organization
AFAEC_RS09520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFAEC_RS09535	COG2966	Psort location CytoplasmicMembrane, score
AFAEC_RS09540	COG3610	response to peptide
AFAEC_RS09545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFAEC_RS09550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS09555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS09560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS09560	COG0649	NAD binding
AFAEC_RS09565	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AFAEC_RS09575	COG0372	Belongs to the citrate synthase family
AFAEC_RS09580	COG1034	ATP synthesis coupled electron transport
AFAEC_RS09585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFAEC_RS09590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFAEC_RS09595	COG0839	Belongs to the complex I subunit 6 family
AFAEC_RS09600	COG0713	ATP synthesis coupled electron transport
AFAEC_RS09605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFAEC_RS09615	COG1007	ATP synthesis coupled electron transport
AFAEC_RS09625	COG1053	succinate dehydrogenase
AFAEC_RS09630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFAEC_RS09645	COG2824	Alkylphosphonate utilization operon protein PhnA
AFAEC_RS09665	COG0840	transmembrane signaling receptor activity
AFAEC_RS09680	COG0840	transmembrane signaling receptor activity
AFAEC_RS09685	COG0840	transmembrane signaling receptor activity
AFAEC_RS09715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFAEC_RS09725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AFAEC_RS09730	COG0372	Belongs to the citrate synthase family
AFAEC_RS09735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFAEC_RS09740	COG2828	Protein conserved in bacteria
AFAEC_RS09745	COG1335	isochorismatase
AFAEC_RS09750	COG0181	hydroxymethylbilane synthase activity
AFAEC_RS09760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFAEC_RS09765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFAEC_RS09775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFAEC_RS09780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFAEC_RS09785	COG0450	alkyl hydroperoxide reductase
AFAEC_RS09795	COG0105	UTP biosynthetic process
AFAEC_RS09805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFAEC_RS09810	COG0416	fatty acid biosynthetic process
AFAEC_RS09815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFAEC_RS09835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFAEC_RS09840	COG0540	Belongs to the ATCase OTCase family
AFAEC_RS09850	COG4773	Receptor
AFAEC_RS09870	COG1706	bacterial-type flagellum-dependent cell motility
AFAEC_RS09880	COG1987	bacterial-type flagellum assembly
AFAEC_RS09905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AFAEC_RS09915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFAEC_RS09930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFAEC_RS09940	COG0288	reversible hydration of carbon dioxide
AFAEC_RS09945	COG0156	8-amino-7-oxononanoate synthase activity
AFAEC_RS09950	COG0792	nuclease activity
AFAEC_RS09965	COG2885	chlorophyll binding
AFAEC_RS09985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFAEC_RS09990	COG0587	DNA-directed DNA polymerase activity
AFAEC_RS09995	COG0693	protein deglycase activity
AFAEC_RS10010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFAEC_RS10015	COG0504	CTP synthase activity
AFAEC_RS10020	COG0348	domain, Protein
AFAEC_RS10030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFAEC_RS10035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFAEC_RS10040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFAEC_RS10050	COG0157	Belongs to the NadC ModD family
AFAEC_RS10055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AFAEC_RS10065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFAEC_RS10075	COG0083	homoserine kinase activity
AFAEC_RS10085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFAEC_RS10090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFAEC_RS10095	COG0779	Required for maturation of 30S ribosomal subunits
AFAEC_RS10100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_RS10100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_RS10110	COG2121	Domain of unknown function (DUF374)
AFAEC_RS10115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_RS10125	COG0195	Participates in both transcription termination and antitermination
AFAEC_RS10130	COG0215	cysteine-tRNA ligase activity
AFAEC_RS10140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFAEC_RS10145	COG0629	single-stranded DNA binding
AFAEC_RS10150	COG0360	Binds together with S18 to 16S ribosomal RNA
AFAEC_RS10165	COG0557	exoribonuclease II activity
AFAEC_RS10170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFAEC_RS10200	COG0343	queuine tRNA-ribosyltransferase activity
AFAEC_RS10205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFAEC_RS10210	COG1393	Belongs to the ArsC family
AFAEC_RS10215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFAEC_RS10225	COG0560	Phosphoserine phosphatase
AFAEC_RS10235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFAEC_RS10245	COG0736	holo-[acyl-carrier-protein] synthase activity
AFAEC_RS10250	COG0601	transmembrane transport
AFAEC_RS10255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFAEC_RS10265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFAEC_RS10275	COG0418	dihydroorotase activity
AFAEC_RS10285	COG0004	ammonium transporteR
AFAEC_RS10305	COG1301	dicarboxylic acid transport
AFAEC_RS10320	COG1742	UPF0060 membrane protein
AFAEC_RS10325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFAEC_RS10335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFAEC_RS10345	COG4191	Histidine kinase
AFAEC_RS10355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFAEC_RS10370	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS10385	COG0840	transmembrane signaling receptor activity
AFAEC_RS10405	COG0511	ligase activity, forming carbon-carbon bonds
AFAEC_RS10440	COG2022	thiamine diphosphate biosynthetic process
AFAEC_RS10445	COG1324	tolerance protein
AFAEC_RS10450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFAEC_RS10450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFAEC_RS10460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFAEC_RS10475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFAEC_RS10480	COG0575	Belongs to the CDS family
AFAEC_RS10510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFAEC_RS10520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFAEC_RS10525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFAEC_RS10545	COG0746	molybdenum cofactor guanylyltransferase activity
AFAEC_RS10550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFAEC_RS10555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFAEC_RS10560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFAEC_RS10565	COG0268	Binds directly to 16S ribosomal RNA
AFAEC_RS10570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFAEC_RS10575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFAEC_RS10605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AFAEC_RS10610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFAEC_RS10615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFAEC_RS10625	COG0505	Belongs to the CarA family
AFAEC_RS10635	COG1686	Belongs to the peptidase S11 family
AFAEC_RS10650	COG1854	S-ribosylhomocysteine lyase activity
AFAEC_RS10655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFAEC_RS10690	COG0352	thiamine-phosphate diphosphorylase activity
AFAEC_RS10690	COG0351	phosphomethylpyrimidine kinase
AFAEC_RS10700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFAEC_RS10705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFAEC_RS10710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFAEC_RS10715	COG5002	protein histidine kinase activity
AFAEC_RS10720	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS10730	COG0704	Plays a role in the regulation of phosphate uptake
AFAEC_RS10735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFAEC_RS10740	COG0581	inorganic phosphate transmembrane transporter activity
AFAEC_RS10745	COG0573	inorganic phosphate transmembrane transporter activity
AFAEC_RS10750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFAEC_RS10755	COG0460	homoserine dehydrogenase
AFAEC_RS10760	COG0436	Aminotransferase
AFAEC_RS10770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFAEC_RS10775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFAEC_RS10780	COG0254	rRNA binding
AFAEC_RS10785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFAEC_RS10795	COG0109	protoheme IX farnesyltransferase activity
AFAEC_RS10880	COG0237	dephospho-CoA kinase activity
AFAEC_RS10885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFAEC_RS10890	COG1410	methionine synthase
AFAEC_RS10890	COG0646	methionine synthase
AFAEC_RS10915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFAEC_RS10915	COG0140	phosphoribosyl-ATP diphosphatase activity
AFAEC_RS10925	COG0489	protein tyrosine kinase activity
AFAEC_RS10945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFAEC_RS10945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFAEC_RS10950	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS10955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFAEC_RS10965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFAEC_RS10985	COG0642	Histidine kinase
AFAEC_RS10990	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS10995	COG0724	RNA recognition motif
AFAEC_RS11000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFAEC_RS11005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFAEC_RS11020	COG0107	imidazoleglycerol-phosphate synthase activity
AFAEC_RS11025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFAEC_RS11030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFAEC_RS11035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AFAEC_RS11035	COG0517	IMP dehydrogenase activity
AFAEC_RS11040	COG1187	pseudouridine synthase activity
AFAEC_RS11045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AFAEC_RS11045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFAEC_RS11055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFAEC_RS11065	COG0367	asparagine synthase
AFAEC_RS11075	COG0306	phosphate transporter
AFAEC_RS11080	COG0513	Belongs to the DEAD box helicase family
AFAEC_RS11085	COG0439	Biotin carboxylase
AFAEC_RS11090	COG0511	ligase activity, forming carbon-carbon bonds
AFAEC_RS11095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_RS11095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFAEC_RS11100	COG0247	lactate metabolic process
AFAEC_RS11105	COG1139	Iron-sulfur cluster binding protein
AFAEC_RS11110	COG1556	Lactate utilization protein
AFAEC_RS11115	COG3852	Histidine kinase
AFAEC_RS11120	COG0745	RESPONSE REGULATOR receiver
AFAEC_RS11125	COG1620	l-lactate permease
AFAEC_RS11145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFAEC_RS11150	COG1733	regulation of RNA biosynthetic process
AFAEC_RS11155	COG0604	alcohol dehydrogenase
AFAEC_RS11170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_RS11175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFAEC_RS11180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFAEC_RS11185	COG0564	pseudouridine synthase activity
AFAEC_RS11205	COG2860	membrane
AFAEC_RS11210	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AFAEC_RS11215	COG2199	diguanylate cyclase activity
AFAEC_RS11215	COG2203	Gaf domain
AFAEC_RS11225	COG4771	TonB-dependent receptor
AFAEC_RS11230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AFAEC_RS11235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFAEC_RS11245	COG0748	coenzyme F420 binding
AFAEC_RS11260	COG3721	Heme iron utilization protein
AFAEC_RS11265	COG2391	methyltransferase activity
AFAEC_RS11270	COG0425	Belongs to the sulfur carrier protein TusA family
AFAEC_RS11345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFAEC_RS11350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFAEC_RS11355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_RS11360	COG1116	anion transmembrane transporter activity
AFAEC_RS11370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFAEC_RS11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFAEC_RS11385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFAEC_RS11390	COG1116	anion transmembrane transporter activity
AFAEC_RS11405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AFAEC_RS11410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFAEC_RS11430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFAEC_RS11435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFAEC_RS11445	COG2199	diguanylate cyclase activity
AFAEC_RS11445	COG3287	FIST C domain
AFAEC_RS11445	COG2200	EAL domain
AFAEC_RS11450	COG1045	serine acetyltransferase
AFAEC_RS11470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AFAEC_RS11475	COG4208	sulfate ABC transporter
AFAEC_RS11480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFAEC_RS11490	COG1408	metallophosphoesterase
AFAEC_RS11505	COG0133	tryptophan synthase activity
AFAEC_RS11515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFAEC_RS11525	COG0582	viral genome integration into host DNA
AFAEC_RS11530	COG2801	Transposase and inactivated derivatives
AFAEC_RS11545	COG4974	Belongs to the 'phage' integrase family
AFAEC_RS11550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFAEC_RS11570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFAEC_RS11580	COG0720	synthase
AFAEC_RS11590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFAEC_RS11595	COG1121	(ABC) transporter
AFAEC_RS11600	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFAEC_RS11685	COG0784	Response regulator, receiver
AFAEC_RS11685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFAEC_RS11780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFAEC_RS11780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFAEC_RS11795	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFAEC_RS11815	COG0419	ATPase involved in DNA repair
AFAEC_RS11820	COG0420	3'-5' exonuclease activity
AFAEC_RS11825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFAEC_RS11830	COG1192	Involved in chromosome partitioning
AFAEC_RS11835	COG1475	DNA binding
AFAEC_RS11845	COG0305	Participates in initiation and elongation during chromosome replication
AFAEC_RS11875	COG0450	alkyl hydroperoxide reductase
AFAEC_RS11880	COG3118	belongs to the thioredoxin family